Podcasts about HOX

In this episode of the Epigenetics Podcast, we talked with Ani Deshpande from Sanford Burnham Prebys about his work on epigenetic regulation and developing small molecules through high throughput screens for AML. Throughout our discussion, we delve into Dr. Despande's journey into the field of biology and science, tracing his evolution from a literature enthusiast in Mumbai to a dedicated cancer researcher. He reflects on his formative experiences during his PhD at Ludwig Maximilian University in Munich, where she developed murine models for refractory acute myeloid leukemia (AML). We examine these models' contributions to therapeutic discovery and understanding the intricate mechanisms underscoring AML's complexities. Transitioning to his postdoctoral work at Scott Armstrong's lab in Boston, Dr. Despande shares his insights on the importance of epigenetic regulators, such as DOT1L, in leukemias, and how they can serve as strategic therapeutic targets. His ambitious pursuit of translational research is further highlighted through his efforts in developing a conditional knockout mouse model and his collaborative work utilizing CRISPR technology to refine our understanding of epigenetic regulation in cancer pathogenesis. Moreover, we engage in a conversation about the challenges and opportunities that arise when establishing his lab at Sanford Burnham Prebys. Dr. Despande candidly discusses the delicate balance between pursuing topics of genuine interest versus adhering to grant fundability, underlining the tension researchers face in the current scientific landscape. His emphasis on the critical need for innovation within lab settings serves as a motivational call for emerging scientists to venture beyond the established templates that often inhibit groundbreaking discoveries. We conclude our dialogue with an exploration of his recent projects, which involve targeting specific epigenetic modifiers and how his lab's findings can contribute to greater understanding and potential treatments for not only AML but also other pediatric cancers driven by gene fusions. Dr. Despande's insights into the integration of modern technologies, such as CRISPR libraries, exemplify his commitment to pushing the boundaries of cancer research. In addition to discussing his scientific contributions, we touch upon Dr. Despande's foray into podcasting (The Discovery Dialogues), shedding light on his motivation to bridge the communication gap between scientists and the broader public. He articulates his desire to demystify scientific discoveries and promote awareness about the intricate journey of research that lays the groundwork for medical advancements. This multidimensional discussion not only highlights his scientific achievements but also emphasizes the importance of effective science communication in fostering public understanding and appreciation of research.   References Deshpande AJ, Cusan M, Rawat VP, Reuter H, Krause A, Pott C, Quintanilla-Martinez L, Kakadia P, Kuchenbauer F, Ahmed F, Delabesse E, Hahn M, Lichter P, Kneba M, Hiddemann W, Macintyre E, Mecucci C, Ludwig WD, Humphries RK, Bohlander SK, Feuring-Buske M, Buske C. Acute myeloid leukemia is propagated by a leukemic stem cell with lymphoid characteristics in a mouse model of CALM/AF10-positive leukemia. Cancer Cell. 2006 Nov;10(5):363-74. doi: 10.1016/j.ccr.2006.08.023. PMID: 17097559. Deshpande AJ, Deshpande A, Sinha AU, Chen L, Chang J, Cihan A, Fazio M, Chen CW, Zhu N, Koche R, Dzhekieva L, Ibáñez G, Dias S, Banka D, Krivtsov A, Luo M, Roeder RG, Bradner JE, Bernt KM, Armstrong SA. AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes. Cancer Cell. 2014 Dec 8;26(6):896-908. doi: 10.1016/j.ccell.2014.10.009. Epub 2014 Nov 20. PMID: 25464900; PMCID: PMC4291116. Sinha S, Barbosa K, Cheng K, Leiserson MDM, Jain P, Deshpande A, Wilson DM 3rd, Ryan BM, Luo J, Ronai ZA, Lee JS, Deshpande AJ, Ruppin E. A systematic genome-wide mapping of oncogenic mutation selection during CRISPR-Cas9 genome editing. Nat Commun. 2021 Nov 11;12(1):6512. doi: 10.1038/s41467-021-26788-6. Erratum in: Nat Commun. 2022 May 16;13(1):2828. doi: 10.1038/s41467-022-30475-5. PMID: 34764240; PMCID: PMC8586238.   Related Episodes Targeting COMPASS to Cure Childhood Leukemia (Ali Shilatifard) The Menin-MLL Complex and Small Molecule Inhibitors (Yadira Soto-Feliciano) MLL Proteins in Mixed-Lineage Leukemia (Yali Dou)   Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

Native Whispers: Our Journey Through Washington's Indigenous Lands Olympic Peninsula's Cultural TapestryTwilight Territory: Exploring La Push and Quileute HeritageThe Real Magic Behind Twilight CountryStanding at the Edge: Discovering America's Corner at Neah BayVenture beyond the Twilight-famous town of Forks as we dive deep into the cultural tapestry of Washington's Olympic Peninsula in this immersive journey through ancient tribal lands.The misty Hoh Rainforest welcomes solo hikers with moss-draped trees and the legacy of the Hoh tribe, whose name derives from "Hox-wool" – referring to the river's fast-moving waters. Walking these ancestral paths feels almost sacred; the forest once provided indigenous communities with materials for shelter, clothing, tools, and the massive cedar canoes that connected their maritime way of life.Our adventure continues to La Push, where the Quileute Nation's history stretches back thousands of years along spectacular driftwood-strewn beaches. This isn't just Jacob Black's fictional homeland – it's a place of genuine cultural resilience, featuring one of the world's few languages without nasal sounds and a community actively preserving their heritage while facing climate challenges. Those massive timber pieces scattered across the shoreline? Remnants of a 1921 storm that leveled nearly 8 billion feet of timber – enough to build 600,000 homes.Perhaps most breathtaking is our journey to Neah Bay, territory of the Makah tribe and home to the northwesternmost point of continental America. The trail feels transported from fantasy – twisted trees forming natural benches, wooden planks guiding travelers across otherworldly terrain, and dramatic cliffs overlooking ocean caves. The Makah Cultural Center houses treasures from one of North America's most significant archaeological discoveries: the ancient village of Ozette, where a mudslide perfectly preserved 55,000+ artifacts of pre-contact indigenous life.When visiting these special places, remember to purchase tribal recreation permits – they're affordable ways to support ongoing cultural preservation while experiencing some of America's most enchanting landscapes. Ready to explore the Olympic Peninsula's indigenous heritage for yourself? Subscribe now and follow our journey across America's most captivating destinations!Thanks for your ongoing support!http://paypal.me/TheROAMiesAlexa and RoryThe ROAMiesPlease subscribe, rate and share our podcast! Follow us at:http://www.TheROAMies.comThe ROAMies: Facebook and Instagram YouTube and X.

English musician Graham Lewis is a  founding member of the legendary post-punk band Wire. Known for his minimal yet charged presence as bassist, vocalist, and lyricist, Graham helped shape the band's stark aesthetic since 1976. Beyond Wire, he's explored experimental sound through projects like Dome, He Said, Hox, and UUUU. An art school background and fascination with the underground shaped his career. Graham is based in Uppsala, Sweden.

Siddharth Ramakrishnan, PhD is a neuroscientist, artist, and educator. He is the Chair of Neuroscience and Professor of Biology at the University of Puget Sound and a recipient of the prestigious National Science Foundation CAREER award. His research spans developmental biology, neuroendocrinology and neuroethics. A Fellow of the UCLA Art|Sci center, his collaborations with artists have led to exhibitions and documentaries that blend the worlds of art and science highlighting topics like Hox genes, animal umwelts and biomimicry. He was also a Fellow at the Pragmatic Health Ethics Research Unit at Montreal (2019). He has had exhibits at MOCA Taipei (2013), the New School of Design (2012), Microwave New Media Festival (2011) and Symposium on Human-Dog Coevolution (2011). An avid Tarot reader, he has designed and created the NeuroTarot deck based on the major arcana of Tarot and infused with neuroscience. He was the keynote speaker at NWTS 2023 and a panelist at the Masters of Tarot workshop (2023) with Mary K. Greer at Omega, Rhinebeck NY. His book "The Neuroscience of Tarot", is out Fall 2024 with Llewelyn Worldwide. https://www.brainmystic.com/ About The Neuroscience of Tarot: "What happens inside your brain when you look at a tarot card? How do you attribute significance to symbols? In this book, Siddharth Ramakrishnan, PhD, answers these questions and more as he explores the neuroscience behind intuition and proves that tarot readers aren't just making up their results. Siddharth unveils the fascinating dance between your body and brain that occurs while delivering or receiving a reading. Learn how this unconscious synergy allows you to process tarot imagery, attach personal meaning, and elicit emotional responses, laying the groundwork for prediction. Filled with dozens of journal exercises and full-color images, this book makes it easy to understand what intuition is scientifically and how to enhance it for more accurate readings from both sides of the table." About Missing WitchesAmy Torok and Risa Dickens produce the Missing Witches Podcast. We do every aspect from research to recording, it is a DIY labour of love and craft. Missing Witches is entirely member-supported, and getting to know the members of our Coven has been the most fun, electrifying, unexpectedly radical part of the project. These days the Missing Witches Coven gathers in our private, online coven circle to offer each other collaborative courses in ritual, weaving, divination, and more; we organize writing groups and witchy book clubs; and we gather on the Full and New Moon from all over the world. Our coven includes solitary practitioners, community leaders, techno pagans, crones, baby witches, neuroqueers, and folks who hug trees and have just been looking for their people. Our coven is trans-inclusive, anti-racist, feminist, pro-science, anti-ableist, and full of love. If that sounds like your people, come find out more. Please know that we've been missing YOU. https://www.missingwitches.com/join-the-coven/

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Hello Interactors,As the year ends, I reflect on 2024's top five essays and a shared theme emerges: the systems that define our lives. These systems intertwine nature and nurture, machines and morality, and markets and minds.From evolution's harmony to the moral balance of economic power, the co-opting of language to the divides between prosperity and precarity, our journey has revealed deep connections between people, place, and power.Let's rewind and reweave these connections into a broader narrative that sets us on our way to another trip around the sun.NATURE, NURTURE, AND NODAL NETWORKSIn “DEVO, Darwin, and the Evo-Devo Dance,” we explored how evolution reflects the eternal interplay between biology and environment, progress and adaptation. The evolution of synthesizers — as my daughter's playful experiments with sound reminded me — offers a metaphor for humanity's relationship with technology.This relationship echoes the broader theme of systems and evolution. Iterative changes and interactions between tools and users offer the potential to create new possibilities. As noted in the essay,"DEVO's fusion of human and machine echoes these evolutionary dynamics, where both biological and technological systems evolve through reconfiguration and integration, creating emergent complexity that Darwin could not have imagined."Just as synthesizers blend natural sound waves with human creativity, humanity's interaction with technology evolves in cycles of adaptation and transformation, shaping both the tools we use and the societies we build. We shape our tools, and they shape us in return.The blend of nature's design and our technological imprint creates an ecosystem of mutual influence, much like the Evo-Devo theories of biology, where small tweaks in developmental genes lead to dramatic evolutionary outcomes.This interplay of creation and transformation mirrors the cycles of human progress. Just as Hox genes orchestrate body plans, societal changes—spurred by technology or ideology—reshape our collective body. Whether it's the mechanistic choreography of DEVO's performances or the emergence of Evo-Devo in biology, the boundaries between human and machine blur.Are we programming nature, or is nature programming us? Perhaps the answer lies not in drawing distinctions but in understanding common patterns. These questions highlight the complexities of how we, and other organisms and systems, grow, adapt, and evolve in a world increasingly interwoven with introduced technology.From the mechanized rhythms of industrialization to the organic flow of natural systems, human -- and nonhuman -- there exists a tension and balance between stability and change. The teleonomic goal-directed behavior of living systems together with society's driving pulse of technology has fused into an unrecognizable but somehow familiar new existence. Even as we invent tools to navigate this existence, we become part of the systems we create—both shapers and shaped.The orchestration of evolution — like the many-layered songs of a many-player band — shows a world of many, connected, but not always planned.MARKETS, MACHINES, AND MORALITYThe Industrial Revolution brought unparalleled progress but also profound moral dilemmas. In “Markets, Machines, and Morality,” we reflected on Adam Smith's dual identity as both an economist and a moral philosopher. For Smith, markets were not just mechanisms of exchange but reflections of human nature. His “Theory of Moral Sentiments” reminds us that sympathy, justice, and prudence are vital governors of economic power — like James Watt's centrifugal governor, which balanced the speed of steam engines.But history shows us that unchecked systems, whether economic or mechanical, often prioritize efficiency over empathy. From Bentham's utilitarian calculus to the exploitative practices of modern capitalism, we've seen how the quest for profit can erode the moral underpinnings of society. Today's tech-driven economies, much like the Industrial Age's steam engines, require careful regulation to prevent runaway consequences. Smith's ideals of community benevolence and fair markets resonate more than ever.The unchecked growth of industrial power also highlights the tensions between human ingenuity and ethical responsibility. The centrifugal governor's simple elegance stands as a metaphor for our need to impose limits on excess, whether in economic policies, technological innovation, or social systems. Without these balancing mechanisms, we risk spiraling into inequity, instability, and dehumanization — a lesson as relevant today as it was in Smith's time.Moreover, the moral fabric underpinning economic actions — sympathy, justice, prudence — often fades in the shadow of profit-driven systems. Yet, these values remain the quiet governors ensuring that society's engines run not just efficiently but equitably.Smith's vision was never limited to wealth accumulation; it was about creating a society where individual pursuits align with collective well-being. Unlike today's economic practices, which often prioritize short-term profit over long-term societal health, Smith emphasized the importance of moral virtues such as sympathy and justice in guiding market dynamics.His insights are less about the "invisible hand" and more reminders to steer not only by the metrics of progress but also by the compass of morality. Like a finely tuned machine, morality should govern the obscene, in a more steady and fair routine.LANGUAGE, LANDSCAPE, AND LOSSLanguage has the power to shape identities and wield influence. These were the themes in “Woke and Wealth” and “Molding Minds Through the Markets of Material Worlds.” Words like “woke” and “decolonize”—once rooted in justice—have been distorted, co-opted by power to serve as tools of division. Similarly, capitalism's framing of “Homo Economicus”—the rational, self-interested individual—has reshaped not just our identities but the very landscapes we inhabit.These constructed identities reflect the power dynamics embedded in economic and geographic systems. The urban centers that thrive on globalized knowledge economies are mirrored by rural regions left to grapple with stagnation and decline, as explored in “Main Street to Metropolis.” As noted in that essay,“Rural areas have become Republican strongholds, drawn to promises of reversing globalization, reshaping economic policies, and making their communities great again.”These places — shaped by policies, demographics, and technology — become symbols of our collective divisions. Yet even amidst these fractures, alternative identities emerge. “Homo Ecologicus,” focused on environmental stewardship, and “Homo Absurdum,” embracing creativity and imagination, remind us of humanity's potential for resilience, community, and connection.The co-opting of language — turning tools of empowerment into instruments of division — illustrates the ongoing struggle for control over cultural and political narratives. When words like “woke” are weaponized, the original call for awareness and justice is lost in a haze of ideological conflict.Meanwhile, the landscapes shaped by economic systems mirror these distortions, transforming places of shared community into arenas of exclusion and competition. Consider, for example, the gentrification of urban neighborhoods. Once vibrant hubs of diverse community life, these areas often transform into exclusive enclaves where rising costs push out long-time residents, replacing shared culture with economic segregation.Yet, within these landscapes of loss lies the potential for renewal. Rural areas, often overshadowed by urban centers, remain spaces where alternative identities thrive. These identities, rooted in stewardship, creativity, and resilience, offer glimpses of a world where humanity's diversity can flourish.The challenge lies in amplifying these voices, reclaiming the power of language, and reshaping the spaces we inhabit to reflect our shared values. Language shapes, landscapes mold — our shifting sense of self is an ancient story retold.CLOSING THE LOOPLooking back at these essays, a recurring theme emerges: the interplay of systems that define our lives is not a one-way street. Nature and nurture, markets and morality, language and identity are all intertwined, multi- referencial, and dynamic webs with mirroring interdependencies. Progress is not linear; it's a cycle of creation, transformation, and sometimes regression where changes to one aspect ripple through the entire system.This echoes the recurring themes explored earlier — from the evolving interplay between nature and technology to the moral balance necessary in markets and machines. Together, these cycles reveal how change, though uneven, can guide us toward resilience and renewal when approached with awareness and intention. Herein lies hope. We all possess the potential, and these systems the possibility, to recalibrate the systems we control to balance human progress with equity, efficiency with empathy, and innovation with ethics.These systems remind us that resilience lies in adaptability. Fire, when controlled, can foster growth and create fertile soil. Uncontrolled fire destroys. Water can unite by sustaining life, connect ecosystems, and enable communication and trade through rivers and oceans. But it can also erode, rot, create barriers, or flood habitats and communities.As we humans innovate and advance, we can pause to reflect on the systems we create. We can ensure they serve not just the few but the many. Like water and fire, the narratives we construct, whether through language, policy, or technology, have the power to unite or divide.Our collective task is to craft stories that inspire connection and foster growth built on shared values. As we step into a new year, what questions should we ask about the systems we create? How can we ensure they unite rather than divide? What would it take to build systems rooted in equity, empathy, and sustainability? Perhaps, most importantly, how do these systems reflect who we are—and who we aspire to be? This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit interplace.io

In this episode of the SolFul Connections podcast, Amanda connects with neuroscientist Siddharth Ramakrishnan about the fascinating intersection of neuroscience and mysticism, particularly through the lens of tarot. Siddharth shares his journey from a technical background in computer science, his study of neuroscience, and embracing his artistic side through the creation of tarot cards. They discuss the importance of intuition, the role of art in science, cultural identity, and the significance of being open to new experiences. Siddharth also touches on spirituality, personal beliefs, and the neuroscience behind decision-making and intuition, culminating in insights from his upcoming book on the neuroscience of tarot. Siddharth Ramakrishnan, PhD is a neuroscientist, artist, and educator. He is the Chair of Neuroscience and Professor of Biology at the University of Puget Sound and a recipient of the prestigious National Science Foundation CAREER award. His research spans developmental biology, neuroendocrinology, and neuroethics. A Fellow of the UCLA Art|Sci Center, his collaborations with artists have led to exhibitions and documentaries that blend the worlds of art and science highlighting topics like Hox genes, animal umwelts, and biomimicry. He was also a Fellow at the Pragmatic Health Ethics Research Unit at Montreal (2019). He has had exhibits at MOCA Taipei (2013), the New School of Design (2012), Microwave New Media Festival (2011) and Symposium on Human-Dog Coevolution (2011). An avid Tarot reader, he has designed and created the NeuroTarot deck based on the major arcana of Tarot and infused with neuroscience. He was the keynote speaker at NWTS 2023 and a panelist at the Masters of Tarot workshop (2023) with Mary K. Greer at Omega, Rhinebeck NY. Visit www.brainmystic.com For more on Siddharth's new book, The Neuroscience of Tarot, visit Llewelyn  Amazon Thinking of starting your own podcast? It's easier than you think. Check out Amanda's affiliate link: Riverside: HD Podcast & Video Software | Free Recording & Editing --- Support this podcast: https://podcasters.spotify.com/pod/show/solfulconnections/support

*More On Biology w/"Prof" Dave: finally this week  Fred Williams and Doug McBurney offer RSR's "definitive" refutation of David James YouTube series allegedly debunking biblical creation.   *Holey Jeans: actually genes... and assumptions David James makes about their contributions to the origins of enzymes, including gene duplication and other evidence "thought to be" in support of evolutionary biology. Sal Cordova dropped the big hammer on such nonsense last May right here on RSR!    *Mutation as Design: Fred critiques the rank stupidity of asserting that genetic mutations produce lots of complex functions and that this can appear as design to the "unprepared" mind, (meaning the mind unprepared by evolutionary propaganda). Even David James' hell bound, fellow traveling, evolutionist fellows at the NIH and Nature know that gene mutations are overwhelmingly harmful!   *RNA from Nothing: Well, not exactly nothing, but David James' assertion that random DNA mutations are an ample source of functional RNA and peptides is equally absurd, and has been refuted by (among others) Rob Carter at Creation Ministries International.   *Haekel, Hox & a Million Bucks: When David "Professor Dave" James Farina condescends to defend, (and even show) Haeckel's hoax slides RSR declares an end to his career. And it's sad that it ended before he could earn the million dollars he bets against creation.      *Body Check: Find out the truth behind more of Professor Dave's "body" of claims at our Professor Dave FACT CHECK page!

TELETHON MONTH: We've got an exciting new announcement! With October being our telethon month, we're looking for 30 new sign-ups for Bob Enyart Subscriptions. These are the best of the best available only at ENYART.SHOP! Please do whatever you can to help us reach our telethon goal of 30 new sign-ups to keep the ministry alive and well!     *More On Biology w/"Prof" Dave: finally this week  Fred Williams and Doug McBurney offer RSR's "definitive" refutation of David James YouTube series allegedly debunking biblical creation.   *Holey Jeans: actually genes... and assumptions David James makes about their contributions to the origins of enzymes, including gene duplication and other evidence "thought to be" in support of evolutionary biology. Sal Cordova dropped the big hammer on such nonsense last May right here on RSR!    *Mutation as Design: Fred critiques the rank stupidity of asserting that genetic mutations produce lots of complex functions and that this can appear as design to the "unprepared" mind, (meaning the mind unprepared by evolutionary propaganda). Even David James' hell bound, fellow traveling, evolutionist fellows at the NIH and Nature know that gene mutations are overwhelmingly harmful!   *RNA from Nothing: Well, not exactly nothing, but David James' assertion that random DNA mutations are an ample source of functional RNA and peptides is equally absurd, and has been refuted by (among others) Rob Carter at Creation Ministries International.   *Haekel, Hox & a Million Bucks: When David "Professor Dave" James Farina condescends to defend, (and even show) Haeckel's hoax slides RSR declares an end to his career. And it's sad that it ended before he could earn the million dollars he bets against creation.      *Body Check: Find out the truth behind more of Professor Dave's "body" of claims at our Professor Dave FACT CHECK page!

Hello Interactors,My daughter has developed a keen interest in synthesizers. She has even created illustrated characters named Morg and Snorf, inspired by keyboard brands like Korg and Nord. Recently, she borrowed an old Korg synthesizer and has begun composing her own music during what she calls, “Korg time”. The evolution of electronic music has been remarkable since its inception, with even classical composers now embracing technology in their work. Notably, Ada Lovelace, one of the earliest computer programmers, foresaw in 1842 that computers would eventually be used for music composition — a prediction that has come to fruition.The blending of acoustic music and computer-generated sounds prompts me to reflect on how we shape our environment, which in turn shapes us. This interplay mirrors the story of evolution: nature nurturing nature ad infinitum. However, I wonder if technology as we know it today will ever truly integrate into the fabric of nature. Will we see human-like robots or robot-like humans? What if technology is already embedded within nature, and we are on the brink of learning to program it just as we would a computer?Let's find out…MAN OR MACHINE?“Are we not men?” This was a question presumably posed to and by members of the band DEVO who masquerade as part human and part machine. The answer by the humorous humanoids was “We are Devo!”. This question and answer became the title of their first album in August of 1978. It served as both a declaration of their band name, DEVO, but also as a rhetorical question that questioned humanity during the early rise of digital technology and its perceived, and actualized, dehumanization.DEVO is an abbreviation of the term de-evolution. The band's founding member, lead singer, and keyboardist, Mark Mothersbaugh had come across a 1924 pamphlet produced by Rev. B.H. Shadduck titled “Jocko-Homo Heavenbound” which critiqued, often humorously, Darwinian evolutionary theory.“Jocko-Homo” translates to Ape-Man which refers to human's evolution from apes. The critique is born out of teleology — the belief organisms are the design of a Christian god…and may be subject to evolutionary decay. Some claimed that by not adhering to the moral precepts of strict forms of Christianity, like dancing or drinking alcohol, that you could pass along devolving genes to your children. As a society, it could lead to a backwards slide of humanity, a devolution.As art students at Kent State, Mothersbaugh and co-founding member and friend Gerry Casale were mostly drawn to the satire and comedic illustrations in ‘Jocko-Homo'. But the book's premise came to the fore when they witnessed the killing of student war protesters in 1973. It made them wonder if perhaps humans really were devolving. After all, the Ohio National Guard had acted more like killing machines, not thinking or feeling humans. They seemingly failed to ask themselves, “Are we not men?”Mothersbaugh and Casale had already begun experimenting with guitar laden punk rock when Mothersbaugh saw Brian Eno perform a synthesizer solo with the band Roxy Music. He'd heard plenty of synth solos from other bands of the 1960s and 70s, but no one played it like Eno — bending and twisting electronic knobs and dials like guitarists and singers bend strings and larynx muscles. Eno sounded and dressed like he'd been transported from the future or another planet.Just a few years later, Brian Eno became the producer for DEVO's first album, “Q: Are we not men? A: We are Devo!”. The album included the song “Jock-Homo” which featured short bursts of monkey sounds Eno synchronized with the machine-like beat of the song. Much like acts of the time, like Roxy Music and David Bowie, DEVO leveraged stage theatrics to convey their message. Their performances featured matching futuristic outfits, often with their red signature energy dome hats. Their choreographed robotic movements reinforced a cyborg-like identity serving as a visual critique of modern society's mechanization.As AI and robots of today have captured the attention of a global society seemingly in decay, it may sound cliché to say, but they, and their contemporaries, were ahead of their time. While I don't believe we are devolving, I do think DEVO accurately portrays, both theoretically and practically, a blending of man and machine that may just be part of developmental evolution — though perhaps not exactly as Darwin had envisioned. Interestingly, DEVO could not have known their band name would become part of a branch of evolutionary biology, called Evo-Devo, or evolutionary developmental biology. That abbreviated term emerged in the early 1980s, perhaps inspired by DEVO.GEOGRAPHY GUIDES GROWTHEvo-Devo, which evolved from 19th-century embryology, explores how the development of an organism grows and matures from a single cell into a fully formed adult. It considers how cell division, their differentiated specialization for specific functions, the development of the resultant organism's shape, and body structures and organs shape evolution.Early thinkers like Karl Ernst von Baer and Ernst Haeckel recognized how species shared similar early developmental stages but then differentiated at later stages. The genetic underpinnings of this wouldn't be fully understood until much later. Darwin recognized these genetic developments as potential drivers of evolutionary change, but it took the Modern Synthesis of the 1930s — which focused on genetics and natural selection — to realize these ideas.By the 1970s, the discovery of mutation genes like Hox genes (which control the body plan of animals) reignited interest in the connection between development and evolution. This research demonstrated how small tweaks in developmental processes could lead to dramatic changes in form. In the 1990s, Evo-Devo solidified as a field, with researchers like Sean B. Carroll emphasizing gene regulation's critical role in shaping life's diversity.Today, Evo-Devo has expanded, embracing genomics and epigenetics to explain how organisms evolve through the complex interplay of genetic and environmental factors, reflecting a broader and more dynamic vision of evolution. In a sense, DEVO's fusion of human and machine echoes these evolutionary dynamics, where both biological and technological systems evolve through reconfiguration and integration, creating emergent complexity that Darwin could not have imagined.While Darwin spent years observing the interplay between biology and the physical environments of the Galápagos and beyond, he also could not have fully anticipated the extent to which physical forces directly influence biological development and shape natural selection.Physical forces play a crucial role in shaping the development of complex biological structures. Mechanical stress, for instance, influences how cells behave during growth and regeneration. Cells respond to tension and pressure in their environment through mechanotransduction — where physical signals are converted into biochemical ones — allowing tissues to adapt to their surroundings.This process is essential, for example, for the simple healing of a small cut to the complex formation of organs where precise force patterns ensure proper development. Similarly, physical stressors like fluid dynamics and gravity are critical in determining the structural features of organisms. In mollusks, for example, the formation of their shells is heavily influenced by the mechanical forces exerted by water currents and the mollusk's own movements. These physical inputs guide how calcium carbonate is deposited, shaping the unique curvature and strength of their shells. These examples highlight how environmental forces and biological development are deeply intertwined, driving evolutionary change through the interaction of physical and genetic processes.This view aligns with the work of researchers like Michael Levin, who propose that environmental cues, including bioelectric and biochemical signals, play a crucial role in guiding the development and behavior of organisms. Michael Levin is a pioneering figure in the field of developmental biology and regenerative medicine, where his groundbreaking work explores how organisms use bioelectric signals to guide growth, regeneration, and even behavior.His research has expanded our understanding of how cells communicate beyond traditional biochemical and genetic pathways, showing that electrical signals between cells play a critical role in shaping an organism's development. Levin, and his collaborators, has demonstrated how manipulating these bioelectric signals with computer programs, they can reprogram biological processes — enabling, for example, the regeneration of complex structures like limbs in animals.This represents a major shift in biology, as it challenges the conventional view that genetic blueprints alone dictate development, highlighting instead the role of bioelectricity as an under appreciated but vital component of life's regulatory networks. In other words, genes can be thought of as hardware and they communicate, collaborate, and compete through bioelectronic circuitry, or software.BLURRING BOUNDARIES, REDEFINING LIFEMichael Levin's research, and others, emphasize that biological systems — whether single cells or complex organisms — operate through networks of bioelectrical, biochemical, and biomechanical signals, processing information much like computers. Cells communicate and make decisions through these signals, allowing them to respond to their environments. In this way, living organisms already function as computational entities, capable of performing sophisticated tasks typically associated with artificial systems.Levin's vision extends into synthetic biology, where organisms might be engineered to function like programmable devices. By manipulating bioelectric and cellular signals, scientists could design organisms capable of performing specific tasks, responding to commands, or adapting their behavior, effectively merging biology with computation. This concept could, for example, blur the distinction between biological pets and programmable machines, imagining a future where living systems are fully customizable.This integration of biology and technology is further reflected in the development of soft robotics and biohybrid systems, where machines incorporate biological tissues for enhanced sensory and adaptive functions. Levin's work on bioelectricity supports the idea that these biological machines could operate through naturally occurring computational processes, challenging traditional distinctions between organic life and artificial intelligence.Clearly these developments raise profound ethical questions, and Levin is the first to say it. It poses many questions about the nature of intelligence, the potential for sentient machines, and the rights of biologically-based computing systems. But these developments could also help advance some of our most pressing health problems.Including in the brain. There's already a brain grown in a petri dish that can learn to play Pong. Called organoids, these are lab-grown, miniature models of human organs, developed from stem cells, can replicate structural and functional characteristics of actual organs.Brain organoids, in particular, mimic basic aspects of brain architecture and neural activity, allowing researchers to study development, disease, and neurological functions in controlled environments. These "brains in a dish" have advanced to the point where they can exhibit learning behaviors, like playing Pong.In this experiment, a brain organoid was connected to electrodes, which allowed it to interact with a simplified version of game. Over time, the organoid learned to play the game by modulating its neural activity in response to feedback from the game environment. This groundbreaking demonstration revealed the potential of organoids not only for studying brain function but also for creating neural systems capable of learning and adapting, pushing the boundaries of artificial intelligence and bioengineering.Such advancements highlight the possibilities of merging biological neural systems with computational tasks, a direction that may influence both neuroscience research and the future of AI. I wonder if DEVO ever imagined their man-machine themes and robotic humanoid movements would have emerged, in experimental form, in their lifetime.DEVO and their contemporaries didn't just create music; they engineered an evolutionary shift in sound that mirrored both cultural and biological processes. By blending analog instruments with emerging technologies like synthesizers and drum machines, their work reflected the modularity featured in Evo-Devo, where biological traits evolve through the recombination of existing genetic modules. Just as Evo-Devo shows how small adjustments in developmental pathways lead to novel evolutionary outcomes, DEVO's music was a synthesis of tradition and innovation, where new soundscapes emerged from reconfiguring the familiar all influenced by the culture and environment in which they exist. This creative evolution parallels biological processes, where complexity arises not linearly but through recursive adaptation and innovation often resulting in sudden unexpected leaps.Much like geography's dynamic role in shaping biological evolution, DEVO's sound was also shaped by external forces — cultural, technological, and industrial. In biology, physical environments like mountains, rivers, and urban landscapes impose selective pressures that drive adaptation, and similarly, DEVO's music arose at the intersection of human creativity and technological advancement. These external forces didn't serve merely as a backdrop but as active, reshaping elements, much like how geographic isolation on islands drives rapid speciation. The adaptability of organisms to urban environments mirrors how DEVO adapted the rigid precision of machines into organic, expressive art, blending the mechanical with the human, much like how species blend with their changing habitats.This fusion of man and machine is now emerging in the cutting-edge field of synthetic biology, where organisms are engineered to function like programmable devices. In the same way that DEVO's music blurred the lines between human creativity and machine precision, synthetic biology allows for living systems to be designed with programmable traits, merging the biological with the technological. Maybe Morg and Snorf will not just be 3D models on a 2D screen, but real bio-sythentic musical pets that invent and collaborate on music together — and with us.These biohybrid systems, where living organisms can perform tasks traditionally associated with machines, further illustrate the evolution of complexity through reconfiguration. Whether in music or existence, the distinctions between what is natural and what is artificial are growing more ambiguous, illustrating the continuous evolution driven by adaptation, creativity, and the interaction with outside forces. References: Fortner, Stephen. "Devo: The Masters of Subversive Synth Rock Return." Keyboard, 1 Sept. 2010, https://www.moredarkthanshark.org/eno_int_keyboard-sep10.html.Wanninger, Andreas, and Tim Wollesen. "The Evolution of Molluscs." Frontiers in Ecology and Evolution 6 (2018): 1-22. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378612/.Conversation with ChatGPT on intersections between Evolution, Geography, and Biological Computing. September, 2024. https://chatgpt.com/. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit interplace.io

Los mamíferos tenemos cuatro juegos de genes Hox, en lugar de uno solo, como la mosca, resultado de dos duplicaciones del juego original

Today's Song of the Day is “The Pit” from Black Market Brass's album Hox, out now.

Someone left a comment on an old article from 2019 on my Simple Explanation blog, and it caused me to reread the article. And, gee, it's a good article. I don't think we've ever shared it here on Gnostic Insights, so I'm going to talk to you today about a Simple Explanation of Gnostic Evolution.        (this podcast refuses to allow me to paste the link to the original Simple Explanation article! grrrr....) There are just a couple of basic ways you can think of evolution.  As commonly taught in school, "scientific" evolution explains the tremendous diversity of life on earth as lucky mutations that add up to great results. Darwinism promotes the idea that mutations and mechanisms morph into increasingly sophisticated life forms because genetic goof-ups allow the ones who change to better survive and dominate those who stayed true to form. These lucky mutations keep going in the same lucky direction until there are so many of them they add up to a new and improved creature, and now they are "evolved."  These developmental genes are the same for all multicellular animals. Evolutionists believe they have been highly conserved through hundreds of millions of years of evolution. [Hox protein classification across model organisms by CLANS analysis, Hueber et al. ] https://www.youtube.com/watch?v=XI8m6o0gXDY&t=8s The second argument for intelligent design is called "specified complexity," which refers to the improbability of essential, highly complex operations arising by chance. The double-strand DNA machinery is one example of a super-complex mechanism where many steps must be accomplished using many components assembled in exactly the right order. Watch the short video below and contemplate how unlikely it is that the DNA replication process "evolved" by chance.  https://www.youtube.com/watch?v=TNKWgcFPHqw&t=1s The complexity of mechanisms at the smallest possible chemical and biological levels argues against their having arisen by happenstance as quickly as they did. Below is the geological clock of earth. Look how soon protokaryotes arose on Earth--just half a billion years after the newly-arrived moon stabilized the planet's tilt and rotation. Yet all of the sophisticated machinery required for assembling and maintaining a cell was already available for use by the newly emerging single-celled organisms; if they hadn't been, the organisms could not have formed. How were those complex processes ready and waiting? By chance? I don't think so. For a religious system that existed long before modern science invented the concept of evolution, Gnosticism has a lot to say about it. The Tripartite Tractate of the Nag Hammadi scriptures that I use for reference, describes us humans as the end result of an unfolding, universal ecosystem it calls "The Economy." The supernatural beings credited with this intelligent design are the Father, the Son, and the Fullness.The Gnostic Gospel suggests that life on earth arose in several cataclysmic steps, with each jump bringing a new order of life to the planet via newly-minted instructions. The jump that started the Earth-ball rolling was the Fall itself, when a higher-order being named "Logos" tried to plug itself into an unauthorized location ("The Father") in order to accomplish a task it was not assigned. The Fall of Logos is the seminal act of the Gnostic creation story. When Logos "fell," it broke apart into all of its component pieces. The ruptured body of Logos is called "The Deficiency." The consciousness of Logos abandoned its dispersed components "down below" and fled back up to the Fullness. The abandoned components of Logos assembled themselves into "Those of the Imitation." Those of the Imitation are organized at the molecular level. They are unable to work together or to procreate with others of their kind. The Simple Gnostic Gospel now identifies prokaryotic organisms with "Those of the Imitation". These two prokaryotic lineages,

Someone left a comment on an old article from 2019 on my Simple Explanation blog, and it caused me to reread the article. And, gee, it's a good article. I don't think we've ever shared it here on Gnostic Insights, so I'm going to talk to you today about a Simple Explanation of Gnostic Evolution.        (this podcast refuses to allow me to paste the link to the original Simple Explanation article! grrrr....) There are just a couple of basic ways you can think of evolution.  As commonly taught in school, "scientific" evolution explains the tremendous diversity of life on earth as lucky mutations that add up to great results. Darwinism promotes the idea that mutations and mechanisms morph into increasingly sophisticated life forms because genetic goof-ups allow the ones who change to better survive and dominate those who stayed true to form. These lucky mutations keep going in the same lucky direction until there are so many of them they add up to a new and improved creature, and now they are "evolved."  These developmental genes are the same for all multicellular animals. Evolutionists believe they have been highly conserved through hundreds of millions of years of evolution. [Hox protein classification across model organisms by CLANS analysis, Hueber et al. ] https://www.youtube.com/watch?v=XI8m6o0gXDY&t=8s The second argument for intelligent design is called "specified complexity," which refers to the improbability of essential, highly complex operations arising by chance. The double-strand DNA machinery is one example of a super-complex mechanism where many steps must be accomplished using many components assembled in exactly the right order. Watch the short video below and contemplate how unlikely it is that the DNA replication process "evolved" by chance.  https://www.youtube.com/watch?v=TNKWgcFPHqw&t=1s The complexity of mechanisms at the smallest possible chemical and biological levels argues against their having arisen by happenstance as quickly as they did. Below is the geological clock of earth. Look how soon protokaryotes arose on Earth--just half a billion years after the newly-arrived moon stabilized the planet's tilt and rotation. Yet all of the sophisticated machinery required for assembling and maintaining a cell was already available for use by the newly emerging single-celled organisms; if they hadn't been, the organisms could not have formed. How were those complex processes ready and waiting? By chance? I don't think so. For a religious system that existed long before modern science invented the concept of evolution, Gnosticism has a lot to say about it. The Tripartite Tractate of the Nag Hammadi scriptures that I use for reference, describes us humans as the end result of an unfolding, universal ecosystem it calls "The Economy." The supernatural beings credited with this intelligent design are the Father, the Son, and the Fullness.The Gnostic Gospel suggests that life on earth arose in several cataclysmic steps, with each jump bringing a new order of life to the planet via newly-minted instructions. The jump that started the Earth-ball rolling was the Fall itself, when a higher-order being named "Logos" tried to plug itself into an unauthorized location ("The Father") in order to accomplish a task it was not assigned. The Fall of Logos is the seminal act of the Gnostic creation story. When Logos "fell," it broke apart into all of its component pieces. The ruptured body of Logos is called "The Deficiency." The consciousness of Logos abandoned its dispersed components "down below" and fled back up to the Fullness. The abandoned components of Logos assembled themselves into "Those of the Imitation." Those of the Imitation are organized at the molecular level. They are unable to work together or to procreate with others of their kind. The Simple Gnostic Gospel now identifies prokaryotic organisms with "Those of the Imitation". These two prokaryotic lineages,

durée : 00:54:05 - La Terre au carré - par : Mathieu Vidard - Ces gènes sont responsables de la spécification des différentes parties du corps pendant le développement de l'embryon. Comment les a-t-on découvert ? En quoi ces recherches sur les gènes Hox sont-elles majeures ?

durée : 00:54:05 - La Terre au carré - par : Mathieu Vidard - Ces gènes sont responsables de la spécification des différentes parties du corps pendant le développement de l'embryon. Comment les a-t-on découvert ? En quoi ces recherches sur les gènes Hox sont-elles majeures ?

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.02.547450v1?rss=1 Authors: Kang, M., Ko, U. H., Oh, E.-J., Kim, H. M., Chung, H. Y., Shin, J. H. Abstract: A scar is considered a natural consequence of the wound-healing process. However, the mechanism by which scars form remains unclear. Here, we suggest a new mechanism of wound healing and scar formation that involves the mechanosensitive regulation of HOX genes. RNA-sequencing of fibroblasts from different types of scars revealed differential HOX gene expression. Computational simulations predicted injury-induced tension loss in the skin, and in vitro experiments revealed a negative correlation between tension and fibroblast proliferation. Remarkably, exogenous tensile stress in fibroblasts has been shown to alter HOX gene expression levels in different scar types. Overall, we propose a model for normal wound healing and scar formation and show that successful wound healing requires tensional homeostasis in the skin tissue, which is regulated by tension-sensitive HOX genes. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Thank you Jonathan Kiser, PA-S and Elliot Davis, OMS IV for developing this podcast. This podcast reviews the basics of Excoriation Disorder. The content helps to distinguish between this and Body Dysmorphic Disorder. We also tried to distinguish between this and OCD, but that was more difficult! The content led to an eye-opening discussion about the role of HOX genes and microglia in the condition. Treatment options were reviewed as well. We enjoyed our discussion and hope you find it as interesting as we did! Thank you to the immortal Jordan Turner for creating the perfect bumper music!

Bria and Flik get their turn at a duo episode. Hox, Books, and Tomas have been missing for 3 months, and the crew finally has a lead. Where have their missing friends gone? Will Bria and Flik be able to find them? And if they do, what state will they be in by the time they get there? Find out on this week's episode of The Last Refuge.    TLR LINKS:  Twitter/Instagram: @dndlastrefuge  Email: dndlastrefuge@gmail.com  Website: www.dndlastrefuge.com  Patreon: www.patreon.com/dndlastrefuge  Merch: bit.ly/tlrmerchstore DMs Guild/DriveThru RPG (use this link when you purchase and TLR gets 5% of whatever you spend!): https://www.dmsguild.com/?affiliate_id=705437  Idle Champions Electrum Chest Code: TIAR-SUNG-PILE (Game info available at CodeNameEntertainment.com)  VoiceMod: DM Jazzy Hands is a VoiceMod Partner! Check out the free version of their digital voice changer here: VoiceMod Website Use code JAZZYHANDS for 5% off a Pro license!  National Network of Abortion Funds: Donate here  DM Jazzy Hands DMs The Fiend of Hollow Mine: Watch here    MUSIC/SOUNDSCAPES:  Druid's Grove - Maiden of the Wild - Score by Marc Cholette  From: BattleBards.com  Under License: BattleBards Podcasters Audio License    Crossing the Chasm by Kevin MacLeod  Free download: https://filmmusic.io/song/3562-crossing-the-chasm  License (CC BY 4.0): https://filmmusic.io/standard-license  Artist website: https://incompetech.com    Oppressive Gloom by Kevin MacLeod  Free download: https://filmmusic.io/song/4174-oppressive-gloom  License (CC BY 4.0): https://filmmusic.io/standard-license  Artist website: https://incompetech.com    "Beautiful" and "World of Magic" by Scott Buckley From: scottbuckley.com.au 

Denis Duboule Collège de France Évolution des génomes et développement (chaire internationale) Année 2021-2022 Gènes du développement et évolution. La transition des nageoires aux membres des tétrapodes Après un rappel des notions importantes développées lors de la cinquième leçon, l'expression des gènes Hox lors du développement de la nageoire pédonculée du poisson à poumon australien Neoceratodus forsteri est décrite à partir de deux études dont les conclusions sont quelque peu différentes. Ensuite, un schéma d'apparition de l'autopode basé sur l'une de ces deux études est discuté. Puis, la régulation fine des gène Hoxd pendant le développement du membre chiridien est décrite au niveau de la structure de la chromatine et des enhancers proximaux et distaux. La présence de cette organisation particulière des paysages de régulation n'est pas observée chez le lancelet (amphioxus), un animal céphalochordé, mais est visible chez le poisson zèbre. Toutefois, l'analyse fonctionnelle de ces paysages de régulation téléostéens chez la souris ne révèle pas de capacité d'expression dans la partie la plus distale des membres, suggérant que si les structures de régulations nécessaires au déploiement des gènes Hox sont déjà présentes chez le poisson zèbre, les enhancers à potentiel distal ne sont pas présent. Par conséquent, à ce niveau d'homologie super-profonde, les poissons osseux ne semblent pas avoir de doigts ou des structures qui pourraient y être assimilées.

Denis Duboule Collège de France Évolution des génomes et développement (chaire internationale) Année 2021-2022 Gènes du développement et évolution. La transition des nageoires aux membres des tétrapodes Après un rappel des notions importantes développées lors de la cinquième leçon, l'expression des gènes Hox lors du développement de la nageoire pédonculée du poisson à poumon australien Neoceratodus forsteri est décrite à partir de deux études dont les conclusions sont quelque peu différentes. Ensuite, un schéma d'apparition de l'autopode basé sur l'une de ces deux études est discuté. Puis, la régulation fine des gène Hoxd pendant le développement du membre chiridien est décrite au niveau de la structure de la chromatine et des enhancers proximaux et distaux. La présence de cette organisation particulière des paysages de régulation n'est pas observée chez le lancelet (amphioxus), un animal céphalochordé, mais est visible chez le poisson zèbre. Toutefois, l'analyse fonctionnelle de ces paysages de régulation téléostéens chez la souris ne révèle pas de capacité d'expression dans la partie la plus distale des membres, suggérant que si les structures de régulations nécessaires au déploiement des gènes Hox sont déjà présentes chez le poisson zèbre, les enhancers à potentiel distal ne sont pas présent. Par conséquent, à ce niveau d'homologie super-profonde, les poissons osseux ne semblent pas avoir de doigts ou des structures qui pourraient y être assimilées.

Denis Duboule Collège de France Évolution des génomes et développement (chaire internationale) Année 2021-2022 Gènes du développement et évolution. La transition des nageoires aux membres des tétrapodes Après un rappel des notions importantes développées lors de la troisième leçon, concernant en particulier le développement de la nageoire pectorale du poisson-zèbre et des deux types de squelettes qui la composent (endo- et exo-), l'utilisation de gènes marqueurs apparaît nécessaire pour essayer d'approfondir les homologies possibles avec le membre antérieur des tétrapodes. Comme marqueurs et déterminants de l'axe proximo-distal, les gènes Hox sont discutés et leur dynamique d'expression pendant le développement du membre chiridien est examinée en détail. Ensuite, le point est fait sur l'existence de ces gènes chez les poissons et leur expression est décrite dans le bourgeon de nageoire à différents stades.

Denis Duboule Collège de France Évolution des génomes et développement (chaire internationale) Année 2021-2022 Gènes du développement et évolution. La transition des nageoires aux membres des tétrapodes Après un rappel des notions importantes développées lors de la troisième leçon, concernant en particulier le développement de la nageoire pectorale du poisson-zèbre et des deux types de squelettes qui la composent (endo- et exo-), l'utilisation de gènes marqueurs apparaît nécessaire pour essayer d'approfondir les homologies possibles avec le membre antérieur des tétrapodes. Comme marqueurs et déterminants de l'axe proximo-distal, les gènes Hox sont discutés et leur dynamique d'expression pendant le développement du membre chiridien est examinée en détail. Ensuite, le point est fait sur l'existence de ces gènes chez les poissons et leur expression est décrite dans le bourgeon de nageoire à différents stades.

Denis Duboule Collège de France Évolution des génomes et développement (chaire internationale) Année 2021-2022 Gènes du développement et évolution. La transition des nageoires aux membres des tétrapodes Après un rappel des notions importantes développées lors de la troisième leçon, concernant en particulier le développement de la nageoire pectorale du poisson-zèbre et des deux types de squelettes qui la composent (endo- et exo-), l'utilisation de gènes marqueurs apparaît nécessaire pour essayer d'approfondir les homologies possibles avec le membre antérieur des tétrapodes. Comme marqueurs et déterminants de l'axe proximo-distal, les gènes Hox sont discutés et leur dynamique d'expression pendant le développement du membre chiridien est examinée en détail. Ensuite, le point est fait sur l'existence de ces gènes chez les poissons et leur expression est décrite dans le bourgeon de nageoire à différents stades.

Denis Duboule Collège de France Évolution des génomes et développement (chaire internationale) Année 2021-2022 Gènes du développement et évolution. La transition des nageoires aux membres des tétrapodes Après un rappel des notions importantes développées lors de la troisième leçon, concernant en particulier le développement de la nageoire pectorale du poisson-zèbre et des deux types de squelettes qui la composent (endo- et exo-), l'utilisation de gènes marqueurs apparaît nécessaire pour essayer d'approfondir les homologies possibles avec le membre antérieur des tétrapodes. Comme marqueurs et déterminants de l'axe proximo-distal, les gènes Hox sont discutés et leur dynamique d'expression pendant le développement du membre chiridien est examinée en détail. Ensuite, le point est fait sur l'existence de ces gènes chez les poissons et leur expression est décrite dans le bourgeon de nageoire à différents stades.

Tiesitkö, että luontotyyppejä suojellaan lainsäädännöllä sekä kansainvälisten sopimusten kautta. Blomiksen luonto esittelee tällä kertaa 4 (neljä) luontotyyppiä. Kuuntele ja mieti mihin luontotyyppiin sinä kuulut. HOX! Blomiksen keväinen luontokuvakilpailu on edelleen menossa. Kuvia voi selata Radio Suomen Facebookissa, voit äänestää suosikkikuvaasi ja halutessasi myös osallistua kilpailuun. Pääsiäisen jälkeen julkistamme voittajan (Blomiksen valinta) ja myös kuuntelijoiden suosikin.

Oli kylmä ja kolea kevätpäivä, kun Blomis sai tiedon reviirillään liikehtivästä Virtasen Väiskistä. Innokkaana, jos kohta varsin kylmänarkana luontomiehenä hän uskaltautui ulos vaakasuoraan satavan rännän keskelle kohdatakseen melkoisen näyn ja kokemaan pienen pettymyksen. Kaikesta tästä Blomis on valmis raportoimaan meille jälleen kerran... HOX! Muista myös Radio Suomen Facebookissa menossa oleva Blomiksen keväinen valokuvakilpailu. Osallistumalla voit voittaa ja vaikket osallistuisikaan voit antaa äänesi suosikkikuvallesi.

The party wraps up with Hox, Breeta, and the rest of the Guardians and make their way east. The plan is to visit with the sailors who made it to the Central Island and hopefully get some intel from them, and then it's off to Silfssn. Yeah. What will our adventurers' final advice be to their friends at the Arcanium? How will they be welcomed among the Kobold sailors? And what's a Baab? Find out on this week's episode of The Last Refuge.    TLR LINKS:  Twitter/Instagram: @dndlastrefuge  Email: dndlastrefuge@gmail.com  Website: www.dndlastrefuge.com  Patreon: www.patreon.com/dndlastrefuge  Merch: bit.ly/tlrmerchstore DMs Guild/DriveThru RPG (use this link when you purchase and TLR gets 5% of whatever you spend!): https://www.dmsguild.com/?affiliate_id=705437  Idle Champions Electrum Chest Code: OINT-BROO-FLOW (Game info available at CodeNameEntertainment.com)    MUSIC/SOUNDSCAPES:  Druid's Grove - Maiden of the Wild - Score by Marc Cholette  Vestige of Eons - Cursed Citadel - Score by Ravi Nidamarthy  Druid's Grove - Life Answers - Score by Richard Daskas  From: BattleBards.com  Under License: BattleBards Podcasters Audio License    The Old Ones  By: Scott Buckley  From: scottbuckley.com.au    Kalimba Relaxation Music by Kevin MacLeod  Link: https://incompetech.filmmusic.io/song/5711-kalimba-relaxation-music  License: https://filmmusic.io/standard-license    Investigations by Kevin MacLeod  Link: https://incompetech.filmmusic.io/song/3924-investigations  License: https://filmmusic.io/standard-license 

The party assesses the prophecies Flik received from his spell. Armed with a bit more information, they decide it's time to deal with the Arcanists that Hox and Breeta have been chatting with, so they return to the third level of the Arcanium. What will Byzdera and Kit make of Flik's prophecies? What awaits them in the Arcanium? And is the conversation with Uzza going to be as difficult to listen to as it was 5 seasons ago? Find out on this week's episode of The Last Refuge.     TLR LINKS:  Twitter/Instagram: @dndlastrefuge  Email: dndlastrefuge@gmail.com  Website: www.dndlastrefuge.com  Patreon: www.patreon.com/dndlastrefuge  Merch: bit.ly/tlrmerchstore DMs Guild/DriveThru RPG (use this link when you purchase and TLR gets 5% of whatever you spend!): https://www.dmsguild.com/?affiliate_id=705437  Idle Champions Electrum Chest Code: PROP-BEEN-EVOE (Game info available at CodeNameEntertainment.com)    MUSIC/SOUNDSCAPES:  Druid's Grove - Maiden of the Wild - Score by Marc Cholette  Prophecy of Scale - The Path of Ash and Dust - Score by Eduardo Lopez  From: BattleBards.com  Under License: BattleBards Podcasters Audio License    Intervention  By: Scott Buckley  From: scottbuckley.com.au    Kalimba Relaxation Music by Kevin MacLeod  Link: https://incompetech.filmmusic.io/song/5711-kalimba-relaxation-music  License: https://filmmusic.io/standard-license 

The party sets off to meet with Hox and the Guardians at the Arcanium. They're curious what plans Hox and Breeta may have cooked up for what to do when the Beast returns, and they've got plenty they can add to the process. What HAVE Hox and Breeta been up to? What advice will they have for our adventurers? And will the party even make it there, knowing they must first cross the dreaded River Ushrog? Find out on this week's episode of The Last Refuge.    TLR LINKS:  Twitter/Instagram: @dndlastrefuge  Email: dndlastrefuge@gmail.com  Website: www.dndlastrefuge.com  Patreon: www.patreon.com/dndlastrefuge  Merch: bit.ly/tlrmerchstore DMs Guild/DriveThru RPG (use this link when you purchase and TLR gets 5% of whatever you spend!): https://www.dmsguild.com/?affiliate_id=705437  Idle Champions Electrum Chest Code: DOUP-EUKS-RIND (Game info available at CodeNameEntertainment.com)    MUSIC/SOUNDSCAPES:  Druid's Grove - Maiden of the Wild - Score by Marc Cholette  Great City - Bastion of the Wood Elves - Score by Yuli Eko Prasetyo  Prophecy of Scale - The Path of Ash and Dust - Score by Eduardo Lopez  Forest - Under the Canopy in Daytime - Soundscape by Richard Daskas  Natural World - Running Stream - Scoundscape by Devan Marotta  From: BattleBards.com  Under License: BattleBards Podcasters Audio License    Borealis By: Scott Buckley  From: scottbuckley.com.au    Kalimba Relaxation Music by Kevin MacLeod  Link: https://incompetech.filmmusic.io/song/5711-kalimba-relaxation-music  License: https://filmmusic.io/standard-license  Wholesome by Kevin MacLeod  Link: https://incompetech.filmmusic.io/song/5050-wholesome  License: http://creativecommons.org/licenses/by/4.0/ 

Une croyance assez répandue voudrait que la taille du pénis soit fonction de celle du nez. Les résultats divergents des études menées à ce jour laissent la question en suspens.Pour certains, la taille du pénis dépend de celle du nez...Des scientifiques japonais ont voulu vérifier cette affirmation selon laquelle la taille de la verge dépendrait de celle du nez.Pour ce faire, ils ont entrepris, entre 2015 et 2019, de mesurer le pénis de 126 hommes décédés. Ne pouvant provoquer d'érection, ils l'ont étiré à la main.Les résultats obtenus conduisent ces scientifiques à penser que la taille du pénis serait bien en relation avec celle du nez. Ce qui voudrait dire, selon eux, que les dimensions du pénis seraient prévues dès la formation de l'embryon.Par contre, aucun lien n'aurait été trouvé entre la taille du nez et le poids des testicules....Pour d'autres nonLa communauté scientifique est divisée sur cette question d'une éventuelle corrélation entre la taille du nez et celle du pénis. En effet, certains croient ce lien infondé. Pour eux, rien ne le prouverait d'un point de vue scientifique.En revanche, ils établissent un lien entre la taille du pénis et celle des doigts. En effet, certains gènes, baptisés "Hox", joueraient un rôle dans le développement des doigts, mais aussi dans celui des organes génitaux.Les travaux d'un généticien suisse renforcent cette hypothèse. En effet, ils auraient montré que la défaillance de ces gènes aurait entraîné des malformations conjointes, des doigts et du pénis.Une autre recherche, menée en 2002 par un médecin grec, tend à corroborer ces résultats. Portant sur une cinquantaine d'hommes, elle cherchait à établir un rapport entre les dimensions du pénis et celles d'autres parties du corps.Or le médecin n'a trouvé de lien qu'entre la taille du pénis et celle de l'index. Des travaux similaires, menés par des scientifiques iraniens en 2007, auraient abouti aux mêmes conclusions.Il est donc possible qu'on puisse déduire de la taille des doigts, et notamment de celle de l'index, celle du pénis. Mais une telle hypothèse reste à confirmer. See acast.com/privacy for privacy and opt-out information.

On todays episode, I speak to Sudarshan Pinglay, a PhD student from NYU medical center. Sudarshan is involved in the dark matter project- we talk about the dark matter of the genome, where introns, repetitive and regulatory elements reside. Sudarshan works specifically on the HOXA locus. The Hox family of genes pattern the head to tail axis in the developing embryo. In mammals, there are are four separate clusters (HoxA,B,C and D). Both space and time of Hox gene expression is colinear to their sequence in the genome. Loss of this leads to serious defects. Sudarshan talks about his wet lab and dry lab work, where he has been using the HoxA cluster as a model to understand how the expression of Hox genes is regulated in order to pattern the developing nervous system. He tells us about his work aiming to build the HoxA cluster from the ground up so that he could manipulate the various players that have been implicated in Hox gene regulation and understand the pattern of Hox gene expression and embryonic development. This is the pre print we discussed in todays episode, and more on the dark matter genome project can be found here. Sudarshan can be found on twitter here!

Vous ne vous êtes jamais dit que la vie serait plus simple avec un bras ou une jambe en plus ? Pour comprendre pourquoi nous n'avons que deux bras, j'ai interrogé Denis Duboule, généticien qui travaille sur la fonction et la régulation des gènes architectes (aussi appelés gènes Hox) au cours du développement des animaux vertébrés. Ce professeur à l'Université de Genève et à l'Ecole polytechnique fédérale de Lausanne, également titulaire à la chaire internationale Evolution des génomes et développement au Collège de France, m'explique d'où viennent nos bras, pourquoi ils se trouvent là où ils sont, et pourquoi nous sommes (comme la majorité des animaux) symétriques. Vous aussi, vous vous posez des questions sur la science ? Envoyez-les à microsciences@rts.ch, elles feront peut-être l'objet d'un futur épisode.

Vous ne vous êtes jamais dit que la vie serait plus simple avec un bras ou une jambe en plus ? Pour comprendre pourquoi nous n'avons que deux bras, j'ai interrogé Denis Duboule, généticien qui travaille sur la fonction et la régulation des gènes architectes (aussi appelés gènes Hox) au cours du développement des animaux vertébrés. Ce professeur à l'Université de Genève et à l'Ecole polytechnique fédérale de Lausanne, également titulaire à la chaire internationale Evolution des génomes et développement au Collège de France, m'explique d'où viennent nos bras, pourquoi ils se trouvent là où ils sont, et pourquoi nous sommes (comme la majorité des animaux) symétriques. Vous aussi, vous vous posez des questions sur la science ? Envoyez-les à microsciences@rts.ch, elles feront peut-être l'objet d'un futur épisode.

This week, the team is joined by Dr. Kirsty Macleod, an evolutionary ecologist and fellow podcaster (W.E.E.)! We walk through both the weird and wild in the 2018 film Annihilation. From horizontal gene transfer, to plants with Hox genes, to faceless, screaming bears, this movie has us all asking: is this shimmer real or is everyone just absolutely hammered? TIME POINTS: 00:00 - 08:18 Intro and News 08:18 - 21:24 Movie synopsis and thoughts 21:24 - 22:53 plugs 22:53 - 41:14 ASSIMILATION TALK 41:14 - 49:20 Ecology of The Thing 49:20 - 54:28 Thoughts on the reworked plot with Libby 54:28-1:01:51 Final thoughts and goodbyes

Another week of comic talk from Marvel, DC, Image, IDW, and more! MODOK is coming! Bruce finally started reading HOX and POX. Bruce and Chris have a long talk about anime (and a little bit of manga).

Pia Zitzmann und Stefanie Kormis haben ein Problem erkannt, das aktuell Millionen (potentielle) Kunden umtreibt: Unergonomisches Arbeiten im Homeoffice und fehlender Stauraum nach Feierabend. Pias und Stefanies Lösung: HOX – die Homeoffice-Box. Im Gespräch mit Jan tüfteln die beiden am Produktdesign, skizzieren verschiedene Produkttests, erörtern ein möglichen Crowdfunding und streifen die Themen Marketing, Vertrieb, Preisfindung und Sortimentsgestaltung. Hör dir diese Folge unbedingt an und nehme Wissen, Erkenntnisse und Anregungen für deinen Geschäftsweg mit! -- Kapitel dieser Folge -- 01:50 Problem -- 04:20 Lösung -- 04:35 Produkt -- 6:20 Design, Prototyp und Serienreife -- 08:30 Kunden und Zielgruppen -- 10:25 Team -- 13:20 Nebenberuflich gründen? -- 14:40 Meilensteine -- 16:20 Schlüsselpartner – 21:00 Vertrieb -- 24:35 Crowdfunding -- 27:00 Marketing und Markttest -- 28:50 Produktion und Produktentwicklung -- 31:35 Wettbewerb -- 32:40 Preisfindung -- Pain Points -- 18:25 Prototypen zeigen?-- 32:50 Wie bestimmen wir den „richtigen“ Preis? -- 34:40 Produkt per Crowdfunding oder SEA testen? – 38:10 Produkt verfeinern oder Sortiment ausbauen? -- Jans Tipps -- 18:25 Präsentation eines Prototyps -- 23:10 Produkttest und Miete anbieten -- 25:00 Crowdfunding-Konzept -- 33:20 Produkt und Design vereinfachen -- 33:40 Ergebnisoffenes Crowdfunding -- 35:10 SEA Testing -- 38:30 Produkt skalierbar machen -- 40:10 Liebe zum Problem wichtiger als zum Produkt – 41:40 Pop-up-Store -- Über die Personen -- [Gast] Stefanie Kormis ist Expertin für Prozessoptimierung und Digitalisierung. Im ersten Corona-Lockdown 2020 arbeitete sie plötzlich im Kinderzimmer statt beim Kunden im Büro. Pia Zitzmann war mehrere Jahre in der Mediaplanung tätig, nach der Elternzeit gründete sie mit Stefanie HOX. Ihre Vision: Das Homeoffice zu einem besseren Ort machen, mithilfe eines flexiblen Möbels, das Ordnung schafft, den Rücken entlastet und nach Feierabend auf schöne Weise „verschwindet“. [Gastgeber] Dr. Jan Evers ist erfahrener Gründungsberater und selbst Unternehmer. Jan berät seit fast 20 Jahren Banken und Ministerien sowie wachstumsstarke Gründer*innen und Mittelständler – als Aufsichtsrat, Business Angel und Miteigentümer. Mehr Infos zu Jan gibt's hier: https://everest-x.de/profil/ -- [Redaktion] Mira Hische [technische Bearbeitung] Benjamin Wölfing -- Weitere Themen -- LaborX -- Geschäftsmodell-Canvas – Nebenberuflich gründen – Ideencouch #25 – Crowdfunding – Marktanalyse – Preiskalkulation – Pop-up-Store -- Über Die Ideencouch -- Die Ideencouch ist ein Podcast von EVEREST. Gastgeber ist Dr. Jan Evers. Wenn du selbst Gründer*in bist, dich Startups faszinieren oder du als Unternehmer*in an deinem eigenen Unternehmen arbeitest, ist dieser Podcast genau der richtige für dich. Aus den Gesprächen zwischen Jan und seinen Gästen wirst du praktisches Wissen, anwendbare Erkenntnisse und kreative Anregungen für deinen Unternehmer*innen-Alltag mitnehmen. Garantiert! -- Du möchtest uns Feedback zu einer Folge geben oder selbst Gast im Podcast sein? Schreib uns einfach eine E-Mail an info@laborx-hamburg.de Wir freuen uns auf deine Nachricht! -- Partner -- LaborX -- Gründerplattform -- Firmenhilfe -- Minicontrol

社会保険労務士の田村が様々な業種で活躍する人の働き方や信条・哲学をインタビューし、新しい働き方を学ぶラジオ番組『教えて、あなたの働き方！』 今回のゲストは前回の続きで、第187回、第188回で登場して頂いたHOXゲームデザイナーの山下ダニエル弘之さんと対談し、役者の世界や理想的な日本の教育のあり方、目指すべき人生観について語ります。 ※このご時世ですのでソーシャルディスタンスに配慮して収録しております。 【ハイライト】 ・ブラジルの劇団と日本の劇団の違い ・責任vs自由の戦い ・相手から否定される事に慣れる為には？ ・ディベートの重要性 ・ルールしか守らない奴が一番怖い ・演技を上手くするコツ HOX様Twitterアカウントはこちら(@info_hox) です。 放送でご紹介があった、HOX様が手掛けるボードゲーム　Suggestion ! -サジェッション！のリンクはこちらです。 https://amzn.to/311UGlG HOX様が手掛けるボードゲームCESSPOOL（セスプール）のリンクはこちらです。 https://amzn.to/3c8Q8QJ ～お知らせ～ サニーデーフライデーは、社会保険労務士として活動する田村が普段のサムライ業という固いイメージから外れ、様々な分野で活躍する方やその道の専門家・スペシャリストと語るトーク番組です。 人生に前向きでポジティブな方をゲストとしてお呼びし、経営者や従業員として働くリスナーの皆様が明日から明るく過ごせて、心や気持ちがパッと晴れるそんな『働き方を考える』ラジオをお送りします。 話すテーマは社労士業、働き方改革、キャリア、海外駐在、外国人雇用、海外放浪等です。 パーソナリティー：田村陽太 産業機械メーカーの海外営業、社労士法人での勤務経験後、社労士事務所を開業。海外駐在員や外国人社員の労務管理、外国人留学生・技能実習生の就労支援等、企業の国際労務・海外進出対応に強い。ラジオDJ、ナレーター、インタビュアー、番組MC・ナビゲーター等、音声メディアや放送業界でも活動。また、番組プロデューサー、ポッドキャストデザイナー等のPRブランディング事業も手掛ける。 カバーアート制作：小野寺玲奈 サニーデーフライデーはTwitterをやっております。 アカウントは＠sunnydayfridayと検索して頂ければ出てきますのでフォローしてください！ またおたよりフォームを設けておりますので、是非ともサニーデーフライデーにおたよりをください！ ↓↓↓↓↓ bit.ly/3gbygo1 各ポッドキャストのプラットフォームで聞けますが、是非とも購読ボタンを押していただき、Apple Podcastsで聴いている方は是非とも評価とレビューを書いてください！

社会保険労務士の田村が様々な業種で活躍する人の働き方や信条・哲学をインタビューし、新しい働き方を学ぶラジオ番組『教えて、あなたの働き方！』 今回のゲストは第187回、第188回で登場して頂いたHOXゲームデザイナーの山下ダニエル弘之さんと対談し、役者の世界や理想的な日本の教育のあり方、目指すべき人生観について語ります。 ※このご時世ですのでソーシャルディスタンスに配慮して収録しております。 【ハイライト】 ・海外で役者を始めたきっかけ ・会社員を尊敬できるランキングベスト3 ・マスオさん、野原ひろしの働き方を見つめる ・将来の理想的な教育のあり方を語る ・演劇=人生の引き出しを増やす事 HOX様Twitterアカウントはこちら(@info_hox) です。 放送でご紹介があった、HOX様が手掛けるボードゲーム　Suggestion ! -サジェッション！のリンクはこちらです。 https://amzn.to/311UGlG HOX様が手掛けるボードゲームCESSPOOL（セスプール）のリンクはこちらです。 https://amzn.to/3c8Q8QJ ～お知らせ～ サニーデーフライデーは、社会保険労務士として活動する田村が普段のサムライ業という固いイメージから外れ、様々な分野で活躍する方やその道の専門家・スペシャリストと語るトーク番組です。 人生に前向きでポジティブな方をゲストとしてお呼びし、経営者や従業員として働くリスナーの皆様が明日から明るく過ごせて、心や気持ちがパッと晴れるそんな『働き方を考える』ラジオをお送りします。 話すテーマは社労士業、働き方改革、キャリア、海外駐在、外国人雇用、海外放浪等です。 パーソナリティー：田村陽太 産業機械メーカーの海外営業、社労士法人での勤務経験後、社労士事務所を開業。海外駐在員や外国人社員の労務管理、外国人留学生・技能実習生の就労支援等、企業の国際労務・海外進出対応に強い。ラジオDJ、ナレーター、インタビュアー、番組MC・ナビゲーター等、音声メディアや放送業界でも活動。また、番組プロデューサー、ポッドキャストデザイナー等のPRブランディング事業も手掛ける。 カバーアート制作：小野寺玲奈 サニーデーフライデーはTwitterをやっております。 アカウントは＠sunnydayfridayと検索して頂ければ出てきますのでフォローしてください！ またおたよりフォームを設けておりますので、是非ともサニーデーフライデーにおたよりをください！ ↓↓↓↓↓ bit.ly/3gbygo1 各ポッドキャストのプラットフォームで聞けますが、是非とも購読ボタンを押していただき、Apple Podcastsで聴いている方は是非とも評価とレビューを書いてください！

Eyce is a personal trainer and CEO of Hox fitness a private fitness studio located in Birmingham. In this episode is sharing with me how he started his journey, how he went from being a personal trainer to building his own Gym ... you can follow his Instagram https://instagram.com/hox_fitness?igshid=128i4us3cui7x --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/phonchrist/message

The first half of this show will soon be an interview with Expert Scrabble Player drmcmoo offering sage advice on how to climb the mountain that is the Collins Lexicon.  Well, why not emerge from your cocoons with a new skill?  Here's your shot: Collins JZXQ Exclusives!  | AZYM  |  | BAJU  |  | BENJ  |  | BEZ  |  | CAZ  |  | CHIZ  |  | COXY  |  | COZE  |  | DIXI  |  | DIXY  |  | DOX  |  | DUX  |  | DZO  |  | EXO  |  | EXUL  |  | FAIX  |  | FIQHS  |  | FLIX  |  | FLOX  |  | GAJO  |  | GAZY  |  | GJU  | GJUS | GJUS  |  | GREX  |  | GUQIN  |  | HIZZ  |  | HOX  |  | JA  |  | JAAP  |  | JAFA  |  | JAGA  |  | JAI  |  | JAK  |  | JANN  |  | JAP  |  | JAPS  |  | JARK  |  | JARP  |  | JASP  |  | JASS  |  | JAXY  |  | JEAT  |  | JEDI  |  | JEEL  |  | JEFF  |  | JIZ  | JAZY, JASY, GIZ, GIZZ | JOBE  |  | JOCO  |  | JOL  |  | JOLL  |  | JOLS  |  | JOMO  |  | JONG  |  | JOR  |  | JORS  |  | JOUR  |  | JUD  |  | JUDS  |  | JURE  |  | JUVE  |  | JYNX  |  | KAZI  |  | KUZU  |  | LANX  |  | LAZO  |  | LEZZ  |  | LOLZ  |  | LULZ  |  | LUZ  |  | MEZZ  |  | MIXY  |  | MIZ  |  | MIZZ  |  | MOZ  |  | MOZE  |  | MOZZ  |  | MUZZ  |  | MYXO  |  | MZEE  |  | NAZE  |  | NOX  |  | OXER  |  | PIZE  |  | POZ  |  | POZZ  |  | QIN  |  | QORMA  |  | QUAIR  |  | QUATS  |  | QUAYD  |  | QUEME  |  | QUENA  |  | QUEYN  |  | QUICH  |  | QUIMS  |  | QUINA  |  | QUINE  |  | QUINO  |  | QUIPO  |  | QUIST  |  | QUOAD  |  | QUOIF  |  | QUONK  |  | QUOPS  |  | QUYTE  |  | RIZ  |  | RIZA  |  | RONZ  |  | SAXE  |  | SAZ  |  | SIJO  |  | SITZ  |  | SJOE  |  | SOZ  |  | SQUIT  |  | SQUIZ  |  | SWIZ  |  | TALAQ  |  | TEX  |  | TOZE  |  | TREZ  |  | TUZZ  |  | ULEX  | &n

Hey SatMs! We're on a short break but we know we can't leave you high and dry! We're throwing back to our first ever episode on Annihilation and bringing you this companion piece to extend your listening pleasure!In this minisode Abi talks with a real life Cell Developmental Biologist, Dr Ezgi Kunttas, who does a much better job of explaining the science behind Hox genes! Welcome back to the shimmer! See acast.com/privacy for privacy and opt-out information.

Espero que tenha gostado do Podcast, e ficarei muito feliz de ter seu feedback, me mande uma mensagem através do meu instagram: https://www.instagram.com/gustavo.celestinohg/ Conheça a Hox: https://www.instagram.com/hox.educa/ --- Send in a voice message: https://anchor.fm/gustavo-celestino/message

Note: Sean B. Carroll the evolutionary biologist and Sean M. Carroll the quantum physicist are both equally awe-inspiring. They are not the same person. Sean’s new book A Series of Fortunate Events: Chance and the Making of the Planet, Life, and You (2020) can be found here: https://www.amazon.co.uk/Fortunate-Events-Chance-Making-Planet/dp/0691218900/ref=tmm_pap_swatch_0?_encoding=UTF8&qid=1611219491&sr=1-1 Sean’s classic book Endless Forms Most Beautiful: The New Science of Evo Devo and the Making of the Animal Kingdom (2005) can be found here: https://www.amazon.co.uk/Endless-Forms-Most-Beautiful-Science/dp/1849160481 His book and film The Serengeti Rules: The Quest to Discover How Life Works can be found here: https://www.seanbcarroll.com/the-serengeti-rules#:~:text=In%20The%20Serengeti%20Rules%2C%20award,the%20planet%20we%20depend%20upon. For more on Sean: https://www.seanbcarroll.com/ Follow Sean on Twitter @SeanBiolCarroll Further References Evo-Devo (Despacito Biology Parody) | A Capella Science - YouTube: https://www.youtube.com/watch?v=ydqReeTV_vk The Hox gene family synteny on chromosome 3 of Drosophila melanogaster... | Download Scientific Diagram (researchgate.net): https://www.researchgate.net/figure/The-Hox-gene-family-synteny-on-chromosome-3-of-Drosophila-melanogaster-and-the-segments_fig4_322698687 Introduction to Trilobites: https://www.trilobites.info/trilobite.htm Eye Development - an overview | ScienceDirect Topics: https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/eye-development Timestamps 03:00 Misunderstandings about chance and probability 04:42 The precise timing of the asteroid strike 66 million years 07:48 Quantum fibrillation in the structure of DNA 14:34 Redundancy in the genome 17:50 How small the differences are that matter 20:51 The central insight of evo devo 28:38 Genetic switches and the choreography of development 32:13 It’s ain’t what you have, it’s the way that you use it. How diversity is achieved. 38:52 Homologous modular structures 43:20 Hox genes and the GPS coordinate system for the body 45:00 Williston’s law and why we have leeway to experiment 49:47 Polarities, how changes in the embryo create changes in the animal 55:02 Chance and the individual

社会保険労務士の田村が様々な業種で活躍する人の働き方や信条・哲学をインタビューし、新しい働き方を学ぶラジオ番組『教えて、あなたの働き方！』今回のゲストは前回の続きで、HOXゲームデザイナーの山下ダニエル弘之さんと対談します。 ※このご時世ですのでソーシャルディスタンスに配慮して収録しております。 【ハイライト】 ・『ごっこ遊び』の重要性 ・『現実を生きる』ための『演じる事』のすすめ ・媚びない姿勢を貫く事 ・世界観の作り方 ・出会いや運を引き寄せる為には？ ・魅力的な人とは？ ・行動する事を恐れない為には？ HOX様Twitterアカウント(@info_hox) です。 HOX様のマーダーミステリー公演詳細です。 西日本でも出来るのでHOX様に是非お問合わせください。 SUNDOG→https://t.co/H8PRbHTsWw 眼窩→https://t.co/4YwySx7mEb Vtuber→https://t.co/QtmvwgTxrN 偽ロミ→https://t.co/bm9YkBnOK5 双極星スクランブル→https://t.co/mH6pPep7Wd ～お知らせ～ サニーデーフライデーは、社会保険労務士として活動する田村が普段のサムライ業という固いイメージから外れ、様々な分野で活躍する方やその道の専門家・スペシャリストと語るトーク番組です。 人生に前向きでポジティブな方をゲストとしてお呼びし、経営者や従業員として働くリスナーの皆様が明日から明るく過ごせて、心や気持ちがパッと晴れるそんな『働き方を考える』ラジオをお送りします。 話すテーマは社労士業、働き方改革、キャリア、海外駐在、外国人雇用、海外放浪等です。 パーソナリティー：田村陽太 産業機械メーカーの海外営業、社労士法人での勤務経験後、社労士事務所を開業。海外駐在員や外国人社員の労務管理、外国人留学生・技能実習生の就労支援等、企業の国際労務・海外進出対応に強い。ラジオDJ、ナレーター、インタビュアー、番組MC・ナビゲーター等、音声メディアや放送業界でも活動。また、番組プロデューサー、ポッドキャストデザイナー等のPRブランディング事業も手掛ける。 カバーアート制作：小野寺玲奈 サニーデーフライデーはTwitterをやっております。 アカウントは＠sunnydayfridayと検索して頂ければ出てきますのでフォローしてください！ またおたよりフォームを設けておりますので、是非ともサニーデーフライデーにおたよりをください！ ↓↓↓↓↓ bit.ly/3gbygo1 各ポッドキャストのプラットフォームで聞けますが、是非とも購読ボタンを押していただき、Apple Podcastsで聴いている方は是非とも評価とレビューを書いてください！

社会保険労務士の田村が様々な業種で活躍する人の働き方や信条・哲学をインタビューし、新しい働き方を学ぶラジオ番組『教えて、あなたの働き方！』今回のゲストは、HOXゲームデザイナーの山下ダニエル弘之さんと対談します。 ※このご時世ですのでソーシャルディスタンスに配慮して収録しております。 【ハイライト】 ・新入社員の思い出 ・人の懐に入るためには？ ・日本と海外の生活習慣の違い ・日本のシステム化社会について ・HOX様の事業概要 ・世にないものを生み出すアイデアについて ・コロナ禍での事業方針について HOX様Twitterアカウント(@info_hox) です。 HOX様のマーダーミステリー公演詳細です。 西日本でも出来るのでHOX様に是非お問合わせください。 SUNDOG→https://t.co/H8PRbHTsWw 眼窩→https://t.co/4YwySx7mEb Vtuber→https://t.co/QtmvwgTxrN 偽ロミ→https://t.co/bm9YkBnOK5 双極星スクランブル→https://t.co/mH6pPep7Wd ～お知らせ～ サニーデーフライデーは、社会保険労務士として活動する田村が普段のサムライ業という固いイメージから外れ、様々な分野で活躍する方やその道の専門家・スペシャリストと語るトーク番組です。 人生に前向きでポジティブな方をゲストとしてお呼びし、経営者や従業員として働くリスナーの皆様が明日から明るく過ごせて、心や気持ちがパッと晴れるそんな『働き方を考える』ラジオをお送りします。 話すテーマは社労士業、働き方改革、キャリア、海外駐在、外国人雇用、海外放浪等です。 パーソナリティー：田村陽太 産業機械メーカーの海外営業、社労士法人での勤務経験後、社労士事務所を開業。海外駐在員や外国人社員の労務管理、外国人留学生・技能実習生の就労支援等、企業の国際労務・海外進出対応に強い。ラジオDJ、ナレーター、インタビュアー、番組MC・ナビゲーター等、音声メディアや放送業界でも活動。また、番組プロデューサー、ポッドキャストデザイナー等のPRブランディング事業も手掛ける。 カバーアート制作：小野寺玲奈 サニーデーフライデーはTwitterをやっております。 アカウントは＠sunnydayfridayと検索して頂ければ出てきますのでフォローしてください！ またおたよりフォームを設けておりますので、是非ともサニーデーフライデーにおたよりをください！ ↓↓↓↓↓ bit.ly/3gbygo1 各ポッドキャストのプラットフォームで聞けますが、是非とも購読ボタンを押していただき、Apple Podcastsで聴いている方は是非とも評価とレビューを書いてください！

Listen on Spotify | Apple Podcasts | Google PodcastsOn this week's episode, Penn Pals has the pleasure of interviewing Penn's own senior lecturer and advisor, John Zimmerman. He earned his PhD from Temple University, and did his post-doctoral work here at the University of Pennsylvania. Teaching both introductory Biology and Genetics, Dr. Zimmerman peels back the layers on the fascinating genetics topic of HOX genes. Short for Homeobox genes, these segments are responsible for the placement and function of parts of our body. If it sounds complicated, it is! However, Dr. Z takes his time and simplifies the concept for us to dive in. Enjoy!Penn Pals is hosted by Dean Wertz and edited by Nicky Belgrad. Podcast artwork by Ava Cruz and Alec Druggan. Music by Bo Hwan Wang.

It's an old school Beat reunion as we welcome the other half of House to Astonish, Paul O'Brien (@ifdestroyed), to discuss the relaunch/reboot of the X-Men with the recently concluded House of X and Powers of X. As a long-time chronicler of the mutant corner on the Marvel Universe with his X-Axis column, who better to examine what Jonathan Hickman has done and might do with the new era of X-books. We chat about the events of HOX and POX, the portrayal of various characters in the book and the new line of books, some of which will written by Hickman. Leaving the X-books aside, there's also talk about noteworthy books that Paul and HTA co-host (and our first pod guest) Al Kennedy (@housetoastonish) have discussed on their show, including Superman's Pal Jimmy Olsen by (former pod guest) Matt Fraction and Steve Lieber, Strange Skies Over East Berlin, Steeple and more. We end the show with some quick wrestling chat, with the first shots of the new Wednesday Night Wars having just been fired a few weeks ago. There's talk about the inaugural AEW shows, what worked and what didn't, the booking so far, the new NWA Power show on Youtube, the greatness of Eddie Kingston and a few other things.

Join Charlie (@geneticghost) and Reed (@armustdie) as they discuss HoX, PoX, DoX, and more! Topics Discussed: Malevolent Geese as 2019 Icons, Comics Charcuterie, Emotions Make You Go Oof, Apocalypse: Not a Barometer for Success Cover image courtesy @maliciousglee, drawn by @karen_xmenfan!

The Nature of “Sacrifice” There are some serious Philosophical and Narrative implications of the long awaited reveal in HoX 5. What does “sacrifice” mean when [...]