Journal of the American Society of Nephrology (JASN)

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JASN, the flagship journal of the ASN, publishes original research reports and basic and clinical science papers relevant to the broad discipline of nephrology. The JASN Podcast features discussions with authors of recently published articles. Moderated by JASN EIC, Josie Briggs, and the editorial fellows, each episode gives a behind the scenes look into the conception of the latest journal articles. New episodes monthly.

American Society of Nephrology


    • May 29, 2025 LATEST EPISODE
    • every other week NEW EPISODES
    • 20m AVG DURATION
    • 77 EPISODES


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    Latest episodes from Journal of the American Society of Nephrology (JASN)

    Regulation of Renal Glucose Handling by mTORC2

    Play Episode Listen Later May 29, 2025 22:58 Transcription Available


    Drs. David Pearce and John Demko discuss the results of their study, "Coordinated Regulation of Renal Glucose Reabsorption and Gluconeogenesis by mTORC2 and Potassium," with JASN Deputy Editor David H. Ellison.

    Drug Screening in Drosophila Nephrocytes

    Play Episode Listen Later May 14, 2025 19:03 Transcription Available


    Dr. Tobias Hermle and Dominik Spitz discuss the findings of their study, "A Drug-Screening Platform for Podocytopathies in Drosophila Nephrocytes," with JASN Deputy Editor Alan S.L. Yu.

    ASN Kidney Translation Series: ADPKD Advances

    Play Episode Listen Later May 7, 2025 69:59 Transcription Available


    On this ASN Kidney Translation Podcast, Dr. Matthew Sparks discusses key ADPKD studies: circadian clock disruption and cyst growth (JASN), depressive symptoms in adults with ADPKD (Kidney360), and biomarker-based kidney outcome prediction (CJASN).

    Anticoagulation in Dialysis Recipients with Atrial Fibrillation

    Play Episode Listen Later Apr 9, 2025 30:42 Transcription Available


    Dr. Ziv Harel discusses findings from his study, "Anticoagulation for Patients with Atrial Fibrillation Receiving Dialysis: A Pilot Randomized Controlled Trial," with JASN Deputy Editor Manjula Kurella Tamura.

    CASR Determines Renal Response to Hypercalcemia

    Play Episode Listen Later Mar 21, 2025 31:29


    Drs. Henrik Dimke and Nina Himmerkus discuss the results of their study, "Calcium-Sensing Receptor in the Thick Ascending Limb and the Renal Response to Hypercalcemia," with JASN Deputy Editor David H. Ellison.

    ASN Kidney Translation Series: ASN Kidney Health Guidance on the Outpatient Management of Patients with Dialysis-Requiring Acute Kidney Injury

    Play Episode Listen Later Mar 11, 2025 33:50


    The ASN Kidney Health Guidance on the Outpatient Management of Patients with Dialysis-Requiring Acute Kidney Injury provides strategies to optimize recovery, implement individualized care, and coordinate best practices in AKI-D management.

    ASN Kidney Translation Series: Kidney Stones

    Play Episode Listen Later Feb 25, 2025 50:45


    In this episode of the ASN Kidney Translation Podcast series, Dr. Matthew Sparks dives into groundbreaking kidney stone research from JASN, CJASN, and Kidney360, exploring CKD risk, asymptomatic stone passage, and how pharmacotherapy affects recurrence.

    Molecular Signature of NPCs in the Catshark

    Play Episode Listen Later Jan 22, 2025 25:13


    Drs. Agnès Boutet and Yasmine Lund-Ricard discuss the findings from their study, "Postembryonic Maintenance of Nephron Progenitor Cells with Low Translational Activity in the Chondrichthyan Scyliorhinus canicula," with JASN Deputy Editor David H. Ellison.

    Acetazolamide and the Kidney in T1D

    Play Episode Listen Later Dec 23, 2024 33:59


    Dr. Charles Ginsberg discusses the results of his study, "Acetazolamide Therapy and Kidney Function in Persons with Nonalbuminuric Diabetes Mellitus Type 1," with JASN Deputy Editor Manjula Kurella Tamura.

    Kidney Protection by Acetylcholine

    Play Episode Listen Later Dec 5, 2024 12:11


    Drs. Luan D. Truong, Richard J. Johnson, and Gabriela Espinosa Garcia discuss the findings from their study, "Production of Acetylcholine by Podocytes and its Protection from Kidney Injury in Glomerulonephritis," with JASN Deputy Editor Alessia Fornoni.

    Genetic Testing in Nephrology

    Play Episode Listen Later Nov 15, 2024 64:22


    On this ASN Kidney Translation episode, Dr. Matthew Sparks hosts discussions on nephrology research in genetics. Topics include genetic testing in CKD, ADTKD screening, and digenic Alport syndrome insights.

    JASN Welcomes Basic Science Research

    Play Episode Listen Later Nov 4, 2024 11:45


    JASN encourages investigators to submit their basic science original research to the journal. Editor-in-Chief Rajnish Mehrotra and Deputy Editors Alessia Fornoni and David H. Ellison discuss the types of basic research that JASN publishes.

    ASN Kidney Translation Series: Novel Therapies for IgA Nephropathy

    Play Episode Listen Later Oct 26, 2024 70:37


    Novel therapies for IgA nephropathy are discussed in this ASN Kidney Translation podcast episode, including efficacy and safety of ravulizumab, selective endothelin receptor antagonist SC0062, and long-term results from a study of atacicept as treatment.

    Polycystin-2 Regulates Natriuretic Peptide Production

    Play Episode Listen Later Oct 8, 2024 16:55


    Drs. Ivana Kuo and Karla M. Márquez-Nogueras discuss the results of their study, "Cardiac Localized Polycystin-2 in the Natriuretic Peptide Signaling Pathway and Hypertension," with JASN Deputy Editor David H. Ellison.

    ASN Kidney Translation Series: ASN Kidney Health Guidance on the Management of Obesity in Persons Living with Kidney Diseases

    Play Episode Listen Later Sep 18, 2024 37:39


    The inaugural ASN Kidney Health Guidance on the Management of Obesity in Persons Living with Kidney Diseases examines psychosocial considerations, lifestyle modifications, pharmacologic options, and metabolic/bariatric surgery.

    KLF15 Agonist in Kidney Disease

    Play Episode Listen Later Sep 4, 2024 18:28


    Drs. Sandeep K. Mallipattu and Bhaskar Das discuss the findings from their study, "A Small Molecule Agonist of Krüppel-Like Factor 15 in Proteinuric Kidney Disease," with JASN Deputy Editor Alessia Fornoni.

    Stem Cells in Renovascular Disease

    Play Episode Listen Later Aug 21, 2024 15:13


    Dr. Lilach O. Lerman discusses the results from her study, "Renovascular Disease and Mitochondrial Dysfunction in Human Mesenchymal Stem Cells," with JASN Deputy Editor Alessia Fornoni.

    ASN Kidney Translation Series: Gender Equity in Nephrology

    Play Episode Listen Later Aug 14, 2024 51:51


    Issues of gender equity in nephrology are covered in an episode of ASN Kidney Translation: An ASN Journals' Podcast, including equal access to mentorship and research opportunities, fellowship programs' parental leave policies, and representation in RCTs.

    Complications of Uninephrectomy

    Play Episode Listen Later Jul 31, 2024 34:55


    Drs. Alicia A. McDonough and Aurelie Edwards discuss the findings from their study, "Potassium-Alkali–Enriched Diet, Hypertension, and Proteinuria following Uninephrectomy," with JASN Deputy Editor David H. Ellison.

    JASN Welcomes Late-Breaking Clinical Trial Manuscript Submissions

    Play Episode Listen Later Jul 1, 2024 13:23


    JASN encourages investigators to submit their late-breaking clinical trial manuscripts for rapid consideration and peer review and, if accepted, online publication in JASN concurrent with Kidney Week.

    sGC Activator Avenciguat for CKD

    Play Episode Listen Later Jun 27, 2024 21:55


    Dr. Hiddo J.L. Heerspink discusses the findings from his study, "Effect of Avenciguat on Albuminuria in Patients with CKD: Two Randomized Placebo-Controlled Trials" with JASN Editor-in-Chief Rajnish Mehrotra.

    Absolute CKD Progression Risk

    Play Episode Listen Later Jun 18, 2024 27:56


    Drs. Maria Clarissa Tio and Tariq Shafi discuss the findings from their study, "Individualized Risk of CKD Progression among US Adults" with JASN Deputy Editor Manjula Kurella Tamura.

    ASN Kidney Translation Series: PPI, Antivirals, and Cough Syrups: Nephrotoxins and Kidney Injury

    Play Episode Listen Later May 16, 2024 69:15


    The effect of pantoprazole on eGFR slope, antiviral medications for Herpes Zoster, & link between pediatric AKI in Uzbekistan and cough syrups are covered in this episode of ASN Kidney Translation: An ASN Journals' Podcast.

    Tubular Effect of Proteinuria

    Play Episode Listen Later May 1, 2024 10:57


    Andrew Hall discusses results of his study, "Spatiotemporal Landscape of Kidney Tubular Responses to Glomerular Proteinuria," with JASN Deputy Editor David H. Ellison.

    Set7 Regulates Glomerular Injury

    Play Episode Listen Later Apr 25, 2024 25:38


    Assam El-Osta discusses the findings from his study, "Set7 Methyltransferase and Phenotypic Switch in Diabetic Glomerular Endothelial Cells," with JASN Deputy Editor David H. Ellison.

    Daprodustat and Heart Failure in CKD

    Play Episode Listen Later Apr 10, 2024 19:18


    Jonathan W. Cunningham and Ajay K. Singh discuss the results of their study, "Daprodustat and Heart Failure in CKD," with JASN Deputy Editor David H. Ellison.

    Changes in ESKD Incidence

    Play Episode Listen Later Mar 13, 2024 10:41


    Susan R. Mendley and Chyng-Wen Fwu discuss the findings of their study, "Age- and Race-Specific Changes in ESKD Incidence over Four Decades," with JASN Editor-in-Chief Rajnish Mehrotra.

    The Final JASN Podcast

    Play Episode Listen Later Jan 12, 2024 25:36


    In this podcast, outgoing Editor-in-Chief Josie Briggs talks with incoming Editor-in-Chief Raj Mehrotra about his vision for the next chapter of JASN.

    SGLT2 Inhibitors and Continuation of Renin Angiotensin Blockade

    Play Episode Listen Later Nov 21, 2023 21:23


    Dr. Briggs and Brendon Neuen discuss his paper in the December issue of JASN. This article on the CREDENCE and EMPA-CKD clinical trials shows that SGLT2 inhibitors allow more consistent use of RAS blockade in patients with declining renal function.

    Kidney Transplant Registry Data: Advice for Users

    Play Episode Listen Later Oct 24, 2023 18:43


    In this podcast, EIC Josie Briggs talks with Associate Editor John Gill about the valuable data resources for research on kidney transplantation. Drs. Gill and Briggs provide some advice for users of these important resources.

    Next Steps in Development of Mesenchymal Stem Cells as Possible Therapeutic for Kidney Disease

    Play Episode Listen Later Oct 10, 2023 25:37


    In this podcast, EIC Josie Briggs talks with Giuseppe Remuzzi about the NEPHSTROM Trial & the next steps in translational work to test the possibility that mesenchymal stem cells can be used as a therapeutic agent to promote repair of kidney damage.

    Historical Redlining and the Incidence of Kidney Failure in US Cities

    Play Episode Listen Later Aug 24, 2023 15:39


    In the podcast, EIC Josie Briggs discusses a paper entitled "Structural Racism, Historical Redlining, and Incidence of Kidney Failure in US Cities" with co-authors Kevin Nguyen and Deidre Crews.

    Antibiotic Use & Kidney Stones and Sodium Bicarbonate & the Vascular Dysfunction of CKD

    Play Episode Listen Later Jul 24, 2023 9:48


    In the episode, EIC Josie Briggs discusses a randomized control trial addressing the impact of sodium bicarbonate on the vascular dysfunction in CKD and an observational case control study of the impact of antibiotic use on kidney stone formation.

    How Many Nephrons in a Human Kidney? A New Number and a Discussion of Why it Matters

    Play Episode Listen Later Jun 22, 2023 15:12


    In this podcast, Dr. Josie Briggs discusses with Dr. Andrew Rule his latest study showing the need to revise our estimate of the number of nephrons in the human kidney.

    The Angiopoietin-Tie 2 Pathway is Ischemic Kidney Injury

    Play Episode Listen Later May 23, 2023 18:47


    In this episode, JASN Associate Editor Katalin Susztak talks with Dr. Susan Quaggin about work from her laboratory on ischemic injury and translational targets in the Angiopoietin-Tie 2 pathway.

    Urea and Uremia

    Play Episode Listen Later Apr 24, 2023 15:51


    JASN EIC Josie Briggs talks with Deputy Editor Tom Hostetter about the unsolved problem of the chemical causes of the uremic syndrome. A new study reports a correlation of outcomes in CKD with protein carbamylation, a breakdown product of urea.

    Genomic Diagnostic Methods for CKD

    Play Episode Listen Later Apr 3, 2023 9:43


    This podcast covers two papers, one describes a clinical workflow for incorporating whole exome sequencing and the other provides evidence genomic disorders contribute to monogenic CKD in adults and children.

    Intensive BP Control and CKD Progression and Prognosis in Anti-GBM Disease

    Play Episode Listen Later Feb 27, 2023 9:43


    In the March podcast, Dr. Briggs discusses a study that addresses prognostic measures in Anti-GBM Disease and a meta-analysis of studies testing whether intensive blood pressure controls slows progression of CKD.

    Pregnancy Risk for Kidney Patients; Cost Effectiveness Research in Dialysis

    Play Episode Listen Later Jan 30, 2023 11:44


    In this Podcast, Dr. Briggs summarizes the goals of the new JASN Special Series, Health Policy Catalyst, and summarizes papers focusing on cost effectiveness research in nephrology and on the special risk of unwanted pregnancies for kidney patients.

    Use of Kidney Organoids to Study Steroid-Resistant Nephrotic Syndrome

    Play Episode Listen Later Jan 5, 2023 19:33


    In this podcast, Dr. Briggs discusses organoid studies with author Dr. Melissa Little. The work explores the varied molecular mechanisms of specific mutations that cause SRNS and suggests promise for eventual design of mutation-specific treatments.

    Highlights in Renal Transplantation

    Play Episode Listen Later Dec 19, 2022 23:09


    In this podcast, EIC Dr Briggs discusses two studies on kidney transplantation with Dr. John Gill. Topics discussed include novel molecular markers and the role of HLA-DQ mismatches, work suggesting new approaches to reduce chronic graft loss.

    Comparing Costs of Hemodialysis and Peritoneal Dialysis

    Play Episode Listen Later Nov 10, 2022 18:03


    In this podcast, EIC Josie Briggs talks with Lekha Tummalapalli about a study addressing costs of hemodialysis and peritoneal dialysis. An editorial on this issue is published in the November (33.11) issue of JASN.

    Gender Differences in Care of CKD Patients

    Play Episode Listen Later Oct 11, 2022 11:32


    In this podcast, JASN EIC, Josie Briggs talks with Juan-Jesus Carrero, Professor of Kidney Disease Epidemiology at Karolinska Institute. His study, published in the October issue of JASN, documents striking differences in care of men and women with CKD.

    Climate Change: Implications for Nephrology

    Play Episode Listen Later Sep 14, 2022 7:43


    In this episode we cover two papers that examine the impact of climate change on nephrology practice. Specifically, the effect of extreme weather events on hemodialysis patient mortality and greenhouse gas emissions associated with dialysis treatment.

    August JASN Highlights: Addressing CKD Progression and Hazards of Intradialytic Hypotension

    Play Episode Listen Later Aug 17, 2022 8:54


    Two highlighted clinical studies: the first addresses the effect of combining a SGLT2 inhibitor and a MRA on proteinuria; the second considers vascular reactivity as a risk factor for cerebral hypoxia when blood pressure falls during dialysis treatments.

    Addressing Racial and Ethnic Disparities in Kidney Disease

    Play Episode Listen Later Jul 13, 2022 20:34


    In this podcast, Dr. Briggs and JASN Deputy Editor, Dr. Donald Wesson discuss the special series highlighted in the July Issue. The series focuses on kidney health disparities with an emphasis on strategies for their elimination.

    Discontinuing Immunosuppressant Use after Allograft Failure: Do We Have the Answers?

    Play Episode Listen Later Jun 15, 2022 6:05


    Dr. Briggs summarizes findings in a study published in the June issue of JASN. The study examines the impact of continued immunosuppression in patients with failed allografts; the effects are surprising and suggest current guidelines may not be optimum.

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