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Can a ketogenic diet improve mental health?This week marks a significant moment for metabolic psychiatry and ketogenic therapy for serious mental illness.A New York Times piece highlighted early research from Stanford University, The Ohio State University, and the University of Edinburgh—alongside stories from individuals who have shared their lived experience here on Metabolic Mind.This kind of visibility matters. It reflects years of work by researchers and clinicians like Drs. Chris Palmer, Shebani Sethi, and Iain Campbell, research funded by Baszucki Group, advocates like Jan Baszucki, as well as the many people who have been willing to share their personal stories.Lived experience alone isn't enough. Early data alone isn't enough. But together, they point to something that must be tested, confirmed — or challenged — through high-quality science. That's why we are excited about several RCTs currently completed or underway around the world.We need to continue efforts to advance education, public awareness and research on a scale that will require public funding. That's how medicine moves forward. And that's the exciting work ahead.
The conversation with formulator Matt Legge pulls back the curtain on the supplement industry, framing it as a metaphysical struggle between genuine intent and the corporate Machine. Matt's journey is a hero's exile from structures like Metagenics, which prioritize efficiency over the soul of the product. This machine churns out soulless, AI-generated formulas that chase "white space," utterly neglecting the deep clinical insight of Root Cause Analysis—a meditation of the pulse. The founder's sacrifice creates the Pearl of Reciprocity, the organizational soul. The primary struggle is protecting this soul from "middle management" by constantly acting as the Chief Reminding Officer (CRO). The ultimate takeaway is a profound choice: to ethically play the regulatory puzzle with a full-spectrum approach and prioritize being the most respected—the "early bird gets the worm"—over merely being the biggest. CORE INSIGHTS: [1:00-1:50] The Formulator's "Exile" and the Call to Invent: Deemed "unemployable" by a major practitioner brand due to his excess of innovative ideas, Matt Legge was effectively pushed to start his own supplement brand. [2:30-3:30] Critique of Claim-Driven Formulation: The core problem in the supplement industry is formulating for claims using single, trademarked extracts, disregarding the natural synergy of multi-ingredient or whole-herb formulations. [5:30-6:30] The Threat of AI-Generated Formulas: New brands often use AI or agencies to formulate identical, "soulless" products (e.g., Ashwagandha, B6, Magnesium Glycinate) based on market "white space," which sidesteps genuine root cause analysis. [9:30-10:30] Root Cause as Clinical "Meditation": Identifying the true root cause is subjective, requiring deep clinical insight—like a "meditation" of the pulse—that goes beyond generic university diagnoses. [11:30-13:00] The Limitations of RCTs in Natural Medicine: The parachute analogy to argue that natural medicine, with thousands of years of traditional use, does not always require modern RCTs that often exclude the sick people the medicine is meant to help. [14:00-15:30] The "Pearl of Reciprocity" and Organizational Soul: Mason views a founder's genuine intent and sacrifice as creating the "Pearl of Reciprocity"—a metaphysical, organizational soul that guides the company toward its purpose of "health and harmony." [29:00-30:00] The Chief Reminding Officer (CRO): To combat high staff turnover ("The Wiggles Theory"), the founder must act as the "Chief Reminding Officer" (CRO), perpetually repeating the brand's foundational ethos and "campfire stories" to maintain its core cultural spirit. [35:30-36:30] Innovation Stifled by Middle Management: Middle management, lacking the company's ethos, stifled innovation by rejecting Matt's inventions because a market segment for the original ideas did not yet exist. [54:30-56:00] The Ethical Full-Spectrum Formulation Approach: Modern ethical formulation uses a nuanced approach: combining standardized extracts (for regulatory claims) with full-spectrum whole herbs to ensure nature's full synergy. RESOURCE: Instagram: leggylegge. LINKEDIN: Matt Legge
The Derm on RheumNow podcast is a collection of Citations and Content curated for dermatologists – addressing Psoriasis, PsA, CLE, vasculitis, HS, other CTD skin disorders. dermatology drugs, biiologics, JAKs - their use, efficacy and side effects. Features Dr. Jack Cush, Editor at RheumNow.com. SHOW NOTES FDA sent a complete response letter to AstraZeneca on their application (BLA) for anifrolumabs (Saphnelo) subcutaneous use in SLE. Despite a positive TULIP-SC trial & EU approval of SC-anifrolumab, FDA & sponsor still have to work things out. CRL reasons are unknown https://t.co/3dNwEyolrj Review of Calcinosis Cutis - Surgical intervent. most effective (excision, curettage, laser ablation, etc). Medical measures inconsistently, partially effective, best if used early & localized (CCB, TCN, probenecid, immunomodulation, biologics, colchicine, NA thiosulfate, & JAKi https://t.co/rv0hQBv6nX Systematic Review of Targeted Rx for Systemic Sclerosis: from 32 RCTs & 2036 pts Rx w/ 23 targeted agents. Guselkumab had greatest effect on mRSS, followed by tofacitinib, inebilizumab, & baricitinib. For FVC, B-cell Rx (belimumab, RTX) had highest efficacy https://buff.ly/vHOSRws Dermatomyositis outcomes w/ 2475 pts (claims) & 1196 pts (EHR). Half had myositis panels & 35% had + MSAbs. Steroid use common in 69% & 74%. HCQ, MTX, MMF. Outocmes (per 1000PYs) wereL all-cause hospitalisation 92, malignancy 15.3, ILD 6.4, and myocarditis 2.1 https://t.co/DJqKGNGX76 Danish DERMBIO registry of psoriasis pts Rx w/ biologics. Among 3790 bionaive pts ustekinumab had best 1-5 yr survival vs (ADA & SEC). In 3403 bioexperienced pts, bimekizumab, guselkumab, & risankizumab had highest 2-year drug survival rate. https://t.co/TInyLPMYkb Real-world study of 1202 #PsA pts shows that secukinumab retention rates were lower w/ smoking (79%/73%/72% in never/former/current smokers) but not w/ obesity (72%/77%/77% in normal/overweight/obese), Adh HR signif. higher w/ former (1.32) & current smokers (1.27) https://t.co/1REWmod73W Together PSO Trial - Combination Ixekizumab and Tirzepatide Today Lilly announced top line results of the TOGETHER-PsO open-label, Phase 3b trial demonstrating the significant benefits of concomitant ixekizumab (IXE: an IL-17A inhibitor) and tirzepatide (TIR: GLP-1agonist) over https://t.co/YWCjN2NyGM
EVOLUT Low Risk data, a provocative meta-analysis, DNR orders, targeted hypothermia, good news in HFpEF evidence, and GLP-1s as AF drugs are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I EVOLUT Low Risk 6-year Results and a 5-year Meta-Analysis of TAVR vs SAVR 6-Year Outcomes of TAVR vs SAVR https://www.jacc.org/doi/10.1016/j.jacc.2026.02.5063 EVOLUT Low Risk Trial at 2 years https://www.nejm.org/doi/full/10.1056/NEJMoa1816885 EVOLUT Low Risk Trial at 3 years https://www.jacc.org/doi/10.1016/j.jacc.2023.02.017 EVOLUT Low Risk Trial at 4 years https://www.jacc.org/doi/10.1016/j.jacc.2023.09.813 Nonproportional Hazards for Time-to-Event Outcomes in Clinical Trials https://www.jacc.org/doi/10.1016/j.jacc.2019.08.1034 TAVR vs SAVR 5-Year Outcomes - Systematic Review https://heart.bmj.com/content/early/2026/02/11/heartjnl-2025-327092 TAVR vs SAVR Updated Meta-Analysis of RCTs https://www.jacc.org/doi/10.1016/j.jacc.2024.12.031 UK TAVI Trial https://jamanetwork.com/journals/jama/fullarticle/2792251 Dr David Cohen on X https://x.com/djc795/status/2023556582030852172?s=46&t=zXMCUoVjSsdyemzWlzeBjA II DNR in the Hospital Inadequate Documentation of Unilateral DNR Orders https://jamanetwork.com/journals/jama/fullarticle/2829203 GeriPal Blog Unilateral DNR Orders https://geripal.org/unilateral-dnr-gina-piscitello-erin-demartino-will-parker/ III Yet another failure of Targeted Hypothermia 2-Year Follow-Up of TTM2 Trial https://jamanetwork.com/journals/jamaneurology/fullarticle/2845193 TTM2 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2100591 IV Good news in HFpEF Evidence ALT-FLOW II Trial https://doi.org/10.1093/ejhf/xuaf016 V GLP-1 as AF drugs Semaglutide as Adjunctive Therapy in Obesity-Related PAF https://doi.org/10.1093/europace/euag018 You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net
Are statins as risky as labels suggest?
In this episode of Chewing It Over, Jack speaks with researcher and osteopath David Evans about what has actually changed in low back pain care over the past 20 years — and what hasn't. Using data from a unique follow-up study comparing physiotherapists, osteopaths, and chiropractors, David reveals that the story is more nuanced than the usual “hands-on vs hands-off” narrative.Spinal manipulation use has fallen across all three professions — not just physios — while massage and acupuncture have increased, suggesting clinicians haven't abandoned hands-on care, but have shifted the type of intervention used. Specific exercises have declined while general exercise has risen, aligning more closely with guideline messaging around activity and self-management. Interestingly, these trends don't map neatly onto clinical guidelines, raising questions about what really drives practice change: pain science discourse, safety concerns, professional identity, training exposure, and system pressures all emerge as possible influences.The conversation moves beyond techniques to bigger issues in MSK care: the limits of pathway-based models, the “average effect” problem in RCTs, and why back pain research may be set up to underestimate treatment impact by measuring outcomes many months later. A major theme is the long-standing struggle to move beyond “non-specific low back pain.” David argues the future may lie in mechanism-based subgrouping (nociceptive, neuropathic, nociplastic, inflammatory) — if diagnostic precision can improve enough to meaningfully guide treatment.
Is everyone really low in vitamin D? Or have we been sold a narrative that doesn't hold up under scrutiny? In this mind-blowing episode, Tara sits down with Regina and Kristin, the investigative duo behind the Normal Curves podcast, to explore the truth behind the so-called "vitamin D deficiency epidemic." Spoiler: it may have been manufactured by outdated, flawed science—and driven by people with major conflicts of interest. This is a must-listen for anyone taking vitamin D or worried about their levels. If you've been told your D is "low," this episode might change everything. In this episode we cover: How the original vitamin D reference ranges were set (and how they were quietly reversed in 2024) Why testing vitamin D routinely may be doing more harm than good The role of conflicts of interest in shaping clinical guidelines What the latest randomized controlled trials (RCTs) actually show about supplementing vitamin D for disease prevention Why observational data can mislead us, and how low D might be the consequence—not the cause—of illness How much sun you actually need to make enough vitamin D (hint: it's a lot less than you think) Why the "low D" narrative stuck around even after the science was overturned If you're thinking about taking D, already taking D, or have been told your vitamin D is "low" (it likely isn't) then this one is for you. WATCH THIS EPISODE ON YOUTUBE -https://www.youtube.com/@TaraThorne Regina Nuzzo is a Gallaudet professor, award-winning science journalist, and co-host of the Normal Curves podcast. She brings statistics to life for students and audiences worldwide, often using sex-science examples to keep things lively. Her writing has appeared in Nature, The New York Times, Scientific American, and the Los Angeles Times, where she wrote a column on the science of sex and relationships. Alongside co-host Kristin Sainani, she penned a long-running statistics column for Physical Medicine & Rehabilitation and now teaches a Stanford summer course on statistics for clinical informatics. Regina's work earned the American Statistical Association's Excellence in Statistical Reporting Award. Kristin Cobb Sainani is a Stanford professor, science journalist, and co-host of the Normal Curves podcast. She brings statistics and scientific writing to students and audiences around the world. She also works as a statistician on sports medicine projects. Kristin has written widely about health, science, and statistics for both academic and popular audiences. She was a health columnist for Allure magazine for ten years and, alongside co-host Regina Nuzzo, penned a long-running statistics column for the journal Physical Medicine & Rehabilitation. In 2018, she received Stanford's Biosciences Award for Excellence in Graduate Teaching. Known for her statistical sleuthing and ability to cut through academic jargon, Kristin champions clear language and rigorous methods in science. Mentioned in this episode: Normal Curves Podcast https://www.normalcurves.com/vitamin-d-part-1-is-the-deficiency-epidemic-real/ https://www.normalcurves.com/vitamin-d-part-2-good-for-more-than-just-your-bones/ Normal Curves Website: https://www.normalcurves.com/ EQUIP PRIME PROTEIN – Click HERE to grab yours and use my code: TARA to get 15% off. When you sign up for a subscription via my link, you'll save 30% on the first month & 15% on any subsequent months! Purchase Herbatonin here to get 15% automatically applied to your cart: https://symphonynaturalhealth.com/Tara PIQUE TEA – These are some of Tara's favourite teas! They're crystal form, which makes them super unique and easy to transport in your purse, (they come in single use satchels!) and higher in polyphenols. They're made from high quality ingredients with triple toxin screening, (super important when it comes to your tea). Click HERE to visit the shop. HRT Made Simple™ - Learn how to confidently speak to your doctor about the benefits of hormone replacement therapy so you can set yourself up for symptom-free, unmedicated years to come without feeling confused, dismissed, or leaving the medical office minus your HRT script. Hair Loss Solutions Made Simple™ – This course will teach you the best natural, highly effective, and safe solutions for your hair loss so you can stop it, reverse it, and regrow healthy hair without turning to medications. The Perimenopause Solution™ – My signature 6-month comprehensive hormonal health program for women in midlife who want to get solid answers to their hormonal health issues once and for all so they can kick the weight gain, moodiness, gut problems, skin issues, period problems, fatigue, overwhelm, insomnia, hair/eyebrow loss, and other symptoms in order to get back to the woman they once were. [FREE] The Ultimate Midlife Perimenopause Handbook - Grab my free guide and RECLAIM your confidence, your mood, your waistline and energy without turning to medications or restrictive diets (or spending a fortune on testing you don't need!). [BOOK A 30-MINUTE SESSION WITH TARA HERE]
In this episode of A Whole New Level, Christopher Gardner, PhD, joins Mike to discuss his decades in nutrition research, the challenges of conducting randomized controlled trials (RCTs) on diet, and how to communicate complex science to the public. Gardner has led some of the most rigorous research ever comparing dietary approaches in real-world conditions, so his insights about what works (cutting processed food and sugar) and what doesn't (obsessing about macronutrients) are worth a listen. Sign Up to Get Your Free Ultimate Guide to Glucose: https://levels.link/wnlIn this episode, we cover:What a nutritional interventionist is – someone who studies people who are asked to change their diet, tracking them and taking samples to see what might have changed.How to square widely-accepted lessons about nutrition (i.e., junk food=bad) with the high degree of individuality in diets that work.The concept of "equipoise" in study design, which means making sure both diets being compared are well-represented versions of that diet (e.g., a "kick butt diet A and a crappy diet B" is avoided).The dilemma of communicating single-study results to the public and the role of the Netflix documentary on Gardner's famous twin study in making science engaging.Dr. Gardner's experience on the Dietary Guidelines Advisory Committee and the methodology used to reach conclusions.The focus on ultra-processed foods and the need to message the consensus points of eating more whole foods and vegetables, and avoiding added sugar and refined grains.The learnings from the DIETFITS study, which compared low-carb and low-fat diets among 600 people for a year, and why there was more variation among people within a diet than between the two diets.
Send us a textMore of us are being seen by nurse practitioners (NPs) and physician associates/assistants (PAs); for routine care outcomes look similar to physician visits, but for complex, new, or worsening problems you should push to see the doctor and ask for clear oversight.Key topicsWhy this is happening: Longer waits and rising demand meet a physician shortfall, so systems lean on NPs/PAs to expand access. New-patient waits average ~31 days, varying widely by city and specialty (AMN). Fewer people have a usual source of care, pushing visits to urgent care/ER (Milbank Scorecard).The scope shift: NP involvement in Medicare outpatient visits rose from 14% in 2013 to ~26% in 2019 (Harvard/Tradeoffs summary). Projections show rapid growth in NP and PA roles through 2030 (ValuePenguin analysis).Training differences (at a glance): NPs typically complete a master's/DNP with ~500–700 supervised clinical hours and, in many states, can practice independently; PAs complete a master's with ~2,000 supervised hours and practice with physician collaboration; physicians complete medical school plus 3–5+ years of residency (~10,000+ hours) and broad rotations—critical for complex differential diagnosis (AJMC overview).Quality of care, by the evidence: For common, protocol-driven issues, outcomes are generally similar. A Cochrane-summarized evidence base finds comparable results for blood pressure control, mortality, and patient satisfaction, with longer counseling time in NP visits (AJMC summary of RCTs). Patients often feel PAs spend more time with them (JAAPA survey). Diabetes care quality appears similar across clinicians (PubMed); NPs tend to deliver more smoking-cessation counseling (AANP brief).Where this works well: Routine follow-ups (blood pressure, cholesterol, diabetes), protocol-based care, minor acute concerns (UTI, simple URI), post-op checks when all is going well—especially with clear physician involvement.When to push for the doctor: New, unclear, or non-resolving problems (e.g., complex headaches, persistent back pain, ongoing fatigue or depression), multiple chronic conditions, many medications, or when a serious alternative diagnosis must be ruled out (e.g., “heartburn” vs. cardiac disease).Advocate for transparency: Ask in advance who you'll see, whether your case will be reviewed with a physician, and how escalation works if you're not improving.TakeawaysAccess will keep driving NP/PA growth; use it to be seen sooner.For routine care, NPs/PAs are often a solid choice with similar outcomes and more counseling time.For complexity, insist on physician evaluation or documented oversight.You have the power to ask questions, confirm the plan, and request escalation when needed.Links mentioned in this episode AMN wait-time trends →
This DIR® Dialogues panel explores the research base behind DIRFloortime®, highlighting both its strong, transdisciplinary foundations and the challenges of measuring developmental, relational change within traditional research models like randomized controlled trials (RCTs). The discussion emphasizes the need to rethink what counts as “evidence,” prioritize outcomes that reflect lived experience and long-term development, and expand research approaches to better support access, funding, and practice across ages and contexts.Link to the show notes with links to key discussion points and other ways to view or hear the episode here: https://affectautism.com/2026/01/23/dir-research/Consider joining our DIR® Parent Network or becoming an Affect Autism member for bonus content and support from a like-minded community of Floortimers here: https://affectautism.com/support/
Exploramos los hallazgos más recientes sobre compresiones manuales versus compresiones mecánicas en la reanimación cardiopulmonar. ¿Qué opción ofrece mejores resultados en pacientes con paro cardíaco? ¿Qué deben saber los proveedores de ACLS hoy?
Do high-protein diets “overactivate mTOR” and shorten lifespan?Does protein cycling actually make sense if you care about longevity?And why do so many nutrition rules online come from mechanisms in a petri dish rather than real-world outcome data?In this episode, I'm joined by Eric Helms (3D Muscle Journey) to cut through the noise and rebuild the conversation from first principles: what the evidence actually says when you stop worshipping single pathways and start looking at RCTs, epidemiology, and meaningful endpoints.We cover:Protein & longevity: why many online “certainties” collapse when you focus on outcomes, not just mechanisms The truth about protein cycling and whether “taking breaks” from protein is useful (or just a trend) Aging, anabolic resistance & master athletes: what really changes with age — and how much training can offset it A perspective shift most people miss: how low the minimum effective dose can be to regain muscle and strength after detraining The most underrated part of all: behavior change. How autonomy-supported coaching, identity, and goal hierarchy outperform “finger wagging” and guilt-based adviceIf you care about performance, metabolic health, and longevity — without turning nutrition into a religion — this episode will recalibrate how you think. Less dogma, more data. And a better strategy: not convincing people, but building the conditions for sustainable change.
I was shocked at the comments on this post. Many people, some of them I know to be smart, thought I was nuts for suggesting two middle-aged women who had isolated high LDL-C needn't take meds because their calculated 10-year risk was less than 3% What shocked me is that our guidelines suggest treatment with statins when 10-year risk is ≥ 7.5%. You may not know this but clinicians are supposed to consider cholesterol (and BP) based on overall risk, which include things like age, blood pressure, smoking status as well as HDL. Here is a link to the PCE. It drives me bananas that clinicians don't go over this with patients. They just look at LDL-c in isolation. Content like this comes free of industry support. Please consider becoming a free or paid subscriber.Experts chose this a 7.5% threshold because they felt it was the point where the absolute risk reduction from statins (about 20-25% relative risk reduction) for nonfatal cardiac events outweighed any potential downsides of statins. It is an arbitrary threshold. The thinking: We know from many RCTs that statins reduce future risk by about 20-25% over 5 years. So .25 x the estimated risk outputs the absolute risk reduction. Let's say a person has a calculated risk of 10%. They can expect a 2.5% risk reduction (.25 x 10% = 2.5%) over 10 years. But .25 x 3% = .75, so a person with an estimated risk of 3% who takes a daily pill for 10 years goes to 2.25%. That's not much. Here are some pics of the pushback I recieved:My colleagues rightly point out that atherosclerosis of the coronary arteries is a slow process and longer exposure to lower LDL-c is beneficial. They feel that the 10-year horizon is too short. They cite something called Mendelian randomization studies which find that people who were born with genetic profiles that cause low cholesterol also have low rates of heart attacks. I wrote a post about this. I actually think that statins and blood pressure drugs may have greater effects in younger people who are at lower risk. But come on. Both individuals who I helped calculate risk were below 3%. That's too low to worry about. Further, if you think we treat people with elevated LDL levels who have this low of a risk, why do we need risk calculators? Or…why don't we just treat everyone above a certain age, since age is the largest driver in the calculators? These are issues I spoke with Drs Foy and Murthy about. I learned a ton. I hope you will too. Topics include:* The value of risk calculators* The uncertainty of prediction* The best time window to consider (statin trials were for 5 years; can we assume effect sizes over 5 years are similar at 30 years?) * The causal role of LDL-c vs “metabolic health”* The value of coronary artery calcium testing * Lipoprotein (a) Academic people like to make fun of podcasts, but I can't imagine a more educational 40 minutes. Andrew and Venk are two of the most thoughtful people in cardiology today. Enjoy and consider supporting Sensible Medicine This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
In this episode of the Smarter Not Harder Podcast, Dr. Matthew Bernstein joins Jodi Duval for a pioneering conversation about the rise of metabolic psychiatry — the intersection of mitochondrial health, nutrition, and brain performance. From ketogenic therapy to personalized mental health biomarkers, this episode offers a radically hopeful perspective on treating conditions like depression, OCD, bipolar disorder, and schizophrenia. Join us as we explore: • What metabolic psychiatry is and why it matters now • How insulin resistance, inflammation, and mitochondria affect mood and cognition • Why ketones aren't just fuel — but also powerful brain signals • Tools like CGMs, RCTs, and the ACCORD program • Supplements and real-world protocols for psychiatric healing This episode is for you if: • You or someone you love has struggled with medication-resistant mental illness • You're curious how nutrition and metabolism affect the brain • You want a psychiatrist's view on keto, CGMs, and continuous feedback • You believe mental health deserves smarter, not harder solutions You can also find this episode on… YouTube: https://youtu.be/-B6A63IG9p4 Find more from Dr. Matthew Bernstein: Accord Program: https://accordmh.com/ LinkedIn: https://www.linkedin.com/in/mattbernsteinmd/ Instagram: https://www.instagram.com/accordmh/ Find more from Smarter Not Harder: Website: https://troscriptions.com/blogs/podcast?utm_source=youtube&utm_medium=video&utm_campaign=snh_podcast_guest_episode_2025_10&utm_content=podcast_asset Instagram: https://www.instagram.com/troscriptions Get 10% Off your purchase of the Clinical Metabolomics Module by using PODCAST10 at https://www.homehope.org Get 10% Off your Troscriptions purchase with code POD10 at https://www.troscriptions.com Get daily content from the hosts of Smarter Not Harder by following @troscriptions on Instagram.
Send us a textIn this episode of the Active Mom Podcast, I'm joined again by Dr. Rita Deering, PT, DPT, PhD — Associate Professor of Physical Therapy and Director of the Movement Sciences Laboratory at Carroll University. With 18+ years of clinical experience and 15 years specializing in pelvic health, Dr. Deering is a leading researcher in perinatal musculoskeletal health, pregnancy and postpartum exercise, pelvic floor function, and female athlete performance.This conversation is a must-listen for anyone navigating the overwhelm of women's health information — clinicians, coaches, athletes, and moms trying to get real answers outside the noise. We dig into how to actually interpret research (not just quote it), what different study types really mean, and how to confidently separate evidence-based guidance from trending misinformation on social media.Whether you're dealing with pelvic floor symptoms, postpartum return to running or lifting, perimenopause changes, or pregnancy athletic performance, this episode brings clarity to the research so you can make informed decisions with confidence.We break down:What “evidence-based” actually means in pelvic health & pregnancy fitnessDifferent types of research (RCTs, systematic reviews, case studies) and how to interpret themWhy outliers in research don't invalidate lived experienceMaking research relatable and useful for everyday moms & athletesHow AI, algorithms, and social media fuel misinformationTranslating research to clinical practice without fear-based messagingWhy respectful, nuanced conversation in women's health actually helps patientsTime Stamps1:00 Introduction3:15 making research accessible7:58 what is PubMed13:50 different types of research18:20 transferring research to the clinic22:44 looking at the studies33:19 different levels of evidence37:04 systematic reviews and meta analysis43:10 changing approach to implementing research48:55 where the funding goes51:20 rapid fire questionsCONNECT WITH CARRIEIG: https://www.instagram.com/carriepagliano/Website: https://carriepagliano.comCONNECT WITH RITA:IG: https://www.instagram.com/ritadeeringphd/Website: https://www.carrollu.edu/faculty/deering-rita-phdThe Active Mom Podcast is A Real Moms' Guide to pregnancy, postpartum, perimenopause & beyond for active moms & the professionals who help them in their journey. This show has been a long time in the making! You can expect conversation with moms and professionals from all aspects of the industry. If you're like me, you don't have a lot of free time (heck, you're probably listening at 1.5x speed), so theses interviews will be quick hits to get your the pertinent information FAST! If you love what you hear, share the podcast with a friend and leave us a 5 ⭐⭐⭐⭐⭐ rating and review. It helps us become more visible in the search algorithm! (Helps us get seen by more moms that need to hear these stories!!!!)
Colette is joined by Dr. Ishan Shivanand, mental health researcher, professor, bestselling author, and founder of Yoga of Immortals (YOI). Raised in Indian monasteries within a 21-generation yogic lineage, Dr. Shivanand brings a rare integration of ancient wisdom and modern science. His groundbreaking double-blind RCTs show up to 82% improvement in insomnia, anxiety, depression, and overall quality of life in as little as 4–8 weeks. Together, they explore how meditation, breathwork, Yoga and Ayurveda can transform mental health and how these ancient sciences understood the mind long before modern neuroscience. This conversation offers both profound insight and practical inspiration for anyone seeking holistic wellbeing and preventative health practices. In this episode, they discuss: How a 21-generation monastic lineage shaped Dr. Shivanand's understanding of the mind What ancient Yogic and Ayurvedic teachings reveal about consciousness and brain function Dr. Shivanand's perspective of today's scientific understanding of mental health The surprising results of the 12 month clinical studies on the impact of meditation on short and long term health How Yoga, meditation and breath unlock expanded states of consciousness and why they are essential for human evolution Links & Resources Practice of Immortality Book by Dr. Ishan Shivanand - https://ishanshivanand.com/about-the-book/ Group Digestive Reset Cleanse – Join the next Group Cleanse starting January 23rd, 2026 https://www.elementshealingandwellbeing.com/group-cleanse Private DIgestive Reset Cleanse - choose dates that work for your schedule. Learn more at https://www.elementshealingandwellbeing.com/digestive-reset-cleanse Exciting News: The New Elements of Ayurveda Podcast Community is Live! Over the years, this podcast has blossomed into a global community, a gathering of seekers, healers, and lifelong learners. And now, I'm delighted to share that our revitalized community space is officially open! This new online home was created for those who wish to go deeper into Ayurveda, together. Inside, you'll find: Early access to podcast episodes Member forums for discussion and Q&A Mindfulness and self-care practices Monthly live Zoom meetups Seasonal group challenges and reflections It's a conscious, supportive space to connect, learn, and grow with others walking the Ayurvedic path. Come say hello, introduce yourself, and be part of this living, breathing sangha. Join the new Elements of Ayurveda Podcast Community here: https://www.elementshealingandwellbeing.com/community I look forward to connecting with you soon! Check out Colette's online services: Online Consultations https://www.elementshealingandwellbeing.com/consultations At-home Digestive Reset Cleanse https://www.elementshealingandwellbeing.com/digestive-reset-cleanse Online Daily Habits for Holistic Health Program https://www.elementshealingandwellbeing.com/daily-habits Reset-Restore-Renew Program https://www.elementshealingandwellbeing.com/reset-restore-renew Have questions on Colette's online services? Book a FREE 15 min Services Enquiry Call here. https://www.elementshealingandwellbeing.com/consultations Do I have an accumulation of ama/toxins in my body? Take this quiz to find out https://www.elementshealingandwellbeing.com/resources Stay connected on the Elements Instagram https://www.instagram.com/elementsofayurvedapodcast/ and Facebook https://www.facebook.com/elementshealingandwellbeing Thank you for listening! If this episode supported you, please consider leaving a review and if you think this information would be helpful to family or friends, please share this episode so we can spread this wisdom of Ayurveda. Stay tuned and stay aligned with the Elements of Ayurveda Podcast. Thanks for listening!
Where do our evidence-based guidelines actually come from? In this episode, Christina Rollins sits down with researcher and educator Dr. Amy Ellis to unpack the real process behind developing EAL and ASPEN guidelines.You'll hear:
An elegant study in post-TAVI atrioventricular block, a PSA for my structural colleagues, revascularization in women, and a CTO PCI trial are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I AV Block After TAVR Heart Blocks During vs After TAVR Show Distinct Patterns https://www.medscape.com/viewarticle/heart-blocks-during-vs-after-tavr-show-distinct-patterns-2025a1000ypp Mechanisms Underlying Alterations in Cardiac Conduction After TAVR https://jamanetwork.com/journals/jamacardiology/fullarticle/2842748 II Related PSA Announcement to My Structural Colleagues III Revascularization Strategies in Women with Severe Chronic CAD Women With Chronic Severe CAD Fare Better With CABG vs PCI https://www.medscape.com/viewarticle/women-chronic-severe-cad-fare-better-cabg-vs-pci-2025a1000ygd PCI vs CABG in Women With Chronic CAD https://doi.org/10.1093/eurheartj/ehaf806 PCI vs CABG - Meta-Analysis of 4 RCTs https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02334-5/abstract CABG vs Drug-Eluting Stent Implantation for CAD - Meta-Analysis https://www.jacc.org/doi/10.1016/j.jcin.2016.10.008 RECHARGE trial https://therechargetrial.com/ IV A CTO PCI RCT – But don't get your hopes up Early vs Late-Staged PCI After Subintimal Tracking and Re-entry for CTO https://doi.org/10.1016/j.jacc.2025.09.1598 DECISION CTO trial https://pubmed.ncbi.nlm.nih.gov/30813758/ National Inpatient Sample Database PCI CTO Associated With Higher Mortality https://pubmed.ncbi.nlm.nih.gov/37356643/ V Mandrola's Top 10 Stories You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net
In episode 613, Mike and James discuss with Jessica Kirkwood the evidence for post-exposure prophylaxis of sexually transmitted infections. We go over the 4 RCTs that have looked at the value of a single dose of doxycycline. It does reduce the risk for some specific infections – but as always you need to know the […]
I will be a member of a roundtable discussion on equine dentistry in December, along with a dozen or so other equine dentists. The goal, according to the manager of this discussion, is to table everyone's ideas and to hear everyone's opinion. We have all been asked not to denigrate contributors because equine dentists are siloed into their beliefs and are contentious in defending their beliefs as fact. Facts, however, are facts, and with them, theories can be proven. Sir Arthur Conan Doyle (Adventures of Sherlock Holmes - A Scandal in Bohemia) famously said this: "I never guess. It is a capital mistake to theorize before one has data. Insensibly, one begins to twist facts to suit theories, instead of theories to suit facts." Unfortunately, scientists, veterinarians, and equine dentists have twisted facts to fit theories. Therefore, theories are defended with passion because there are no facts to support them, and all that is left is the emotion of being important. Countering unproven theories are data collected over 84,000 horses that I have floated. With large numbers, patterns develop. This kind of accumulation of observations is called an observational study. They are not anecdotal, which means they are not based on fact. Rather, observational studies are conducted over time with large numbers to identify patterns. They may also be called wisdom or experience and can be supported by evidence from randomized controlled trials (RCTs). However, with limited funding, RCTs will never be conducted. ********** Community.TheHorsesAdvocate.com is a place to learn about horses, horse barns, and farms. Its information is free, and there is a membership side that allows horse owners to attend live meetings to ask questions and deepen their understanding of what they have learned on the site. Membership helps support this message and spread it to everyone worldwide who works with horses. The Equine Practice, Inc. website discusses how and why I perform equine dentistry without immobilization or the automatic use of drugs. I only accept new clients in Florida. Click here to make an appointment. The Horsemanship Dentistry School is a place for those interested in learning how to perform equine dentistry without drugs on 97% of horses. Please give a thumbs-up or a 5-star review and share these everywhere. I know horse owners worldwide listen, and the horses need every one of you in "Helping Horses Thrive In A Human World."
In this high-impact solo episode, Darin strips away the noise, hacks, and hype to deliver a clear, no-BS roadmap for transforming your body, brain, energy, and direction in life. This is a straight-talk breakdown of the 5 foundational habits that matter most — the habits backed by science, ancient wisdom, and Darin's decades-long experience living this work every day. Expect practical steps, micro-experiments, timing rules, and the mindset needed to reclaim sovereignty in a world full of distraction. If you're ready to build a stronger, clearer, more powerful version of yourself… this is the episode. What You'll Learn 00:00 – Welcome to SuperLife How this podcast helps you build sovereignty through real habits, real truth, and real practices. 03:07 – Why this episode is different Darin lays out the mission: habits, hacks, hard truths — without dogma or fluff. 03:44 – The 5 foundational moves that change your biology A preview of the metabolic, physical, mental, and behavioral levers that create huge shifts. 1. METABOLIC EDGE — Eat Like You're Building a Future 04:03 – Terrain theory + why your food timing matters How altering the internal environment of your cells changes everything. 05:02 – The two levers that unlock metabolic health Time-restricted eating + plant-forward whole foods. 05:23 – Compressing your eating window Why 8–10 hours is ideal, how it improves glucose, insulin, weight, and inflammation. 06:18 – Practical weekly ramp-up Week 1: 12 hours. Week 2: 8–10 hours. Simple, sustainable, achievable. 07:10 – Darin's personal eating window 10 a.m. to 6 p.m. — and why eating earlier aligns with digestive fire. 2. MOVEMENT THAT MATTERS — Strength Is Survival 11:04 – Why strength training is non-negotiable Muscle protects metabolism, bone density, insulin sensitivity, and longevity. 11:51 – What the evidence says Huge cohort studies show strength training reduces all-cause mortality. 12:23 – The perfect weekly formula 3x/week compound lifts + daily movement + micro-bursts every hour. 13:06 – Real-life practicality Darin's routine of walking, sprinting dogs, mountain biking, and breaking up the day with movement. 3. SLEEP — The Ultimate Biological Reset 16:26 – The truth everyone ignores You cannot out-supplement or out-biohack poor sleep. 16:40 – The real impact of chronic sleep loss Cognition, memory, hormones, emotional regulation — all decline. 17:37 – The universal rule: consistent timing Same bedtime ± 30 minutes, every night. 17:52 – 60-minute wind-down protocol Screens off, light down, nervous system softening. 18:32 – Using sauna as a down-regulation tool Infrared benefits + why Darin does it twice a day in winter. 4. MINDSET & CONSCIOUSNESS — Your Attention Is Your Power 20:00 – Why optimization fails without attention training You can master food, workouts, and sleep — but scattered attention destroys progress. 20:48 – Darin's morning protocol Water → elixir → infrared pad → meditation → visualization → journaling. Every day. Everywhere. 21:01 – Meta-analysis proof Meditation reduces anxiety, depression, stress — and rewires your brain. 21:23 – The perfect 10-minute breathwork formula 5–5–5–5 or 4–4–4–4 cycles for nervous system reset. 21:56 – Journaling as medicine Stream-of-consciousness to activate clarity and emotional release. 5. WEALTH — Treat Your Time Like Capital 22:36 – Redefining wealth It's not money — it's your magnetism, output, relationships, and purpose. 23:16 – The compounding effect of tiny decisions Time batching, micro-actions, and protecting your attention from the social media attention economy. 24:02 – Mini productivity framework 90 seconds → 3 important calls. Every Friday → 1 paragraph on what scaled this week. 25:14 – Darin's post-meditation rule No scrolling — replace with proactive actions: reading, outreach, Patreon replies. FINAL TAKEAWAYS 26:02 – The master checklist: • Time-restricted eating • Plant-focused meals • Resistance training • Daily meditation • Consistent sleep • Sauna recovery • Treating time like capital 26:11 – The real danger Chasing hacks before mastering fundamentals leads to burnout, confusion, and stress. 27:58 – Your power is in the basics These are simple, accessible, and life-changing. 28:04 – Closing message "Have your best Super Life Day ever." Thank You to Our Sponsors Our Place: Toxic-free, durable cookware that supports healthy cooking. Go to their website at fromourplace.com/darin and get 35% off sitewide in their largest sale of the year. Manna Vitality: Go to mannavitality.com/ and use code DARIN12 for 12% off your order. Join the SuperLife Community Get Darin's deeper wellness breakdowns — beyond social media restrictions: Weekly voice notes Ingredient deep dives Wellness challenges Energy + consciousness tools Community accountability Extended episodes Join for $7.49/month → https://patreon.com/darinolien Find More from Darin Olien: Instagram: @darinolien Podcast: SuperLife Podcast Website: superlife.com Book: Fatal Conveniences Key Takeaway "Your biology changes when your decisions change. Nail your sleep, nail your strength, honor your attention, and treat your time like capital — and you will build a Super Life from the ground up." Bibliography Time-restricted eating (human RCTs / reviews) — Wilkinson et al., 10-hour TRE reduced weight and improved cardiometabolic markers (2019). PMC Intermittent fasting / metabolic health review — comprehensive reviews showing metabolic switching benefits. PMC+1 Plant-forward/vegetarian diets & cardiometabolic outcomes — BMJ/Nutrition reviews and JAMA network evidence showing improved CVD risk markers and metabolic benefits. BMJ Nutrition+1 Sleep and cognition / brain health — Nature/Harvard coverage & meta-analyses: short sleep impairs cognition and links to amyloid processes. Nature+1 Resistance training & mortality / physical function — systematic and cohort evidence that muscle-strengthening activity lowers risk and preserves function. British Journal of Sports Medicine+1 Mindfulness & mental health meta-analysis — Goyal et al. 2014 and subsequent meta-analyses showing reductions in anxiety/stress. PubMed+1 Sauna bathing and cardiovascular outcomes — JAMA Internal Medicine / Mayo Clinic Proceedings reviews on sauna and lower CVD risk signals.
This year, the non-profit Educate Girls became the first Indian organization ever to receive the Ramon Magsaysay Award—often called Asia's Nobel Prize. The foundation recognized the group for its groundbreaking work enrolling out-of-school girls, improving learning outcomes, and shifting social norms in some of India's most underserved communities. It's a remarkable milestone for an NGO that began in rural Rajasthan and now reaches millions of households across the country.To discuss the challenges—and the opportunities—surrounding girls' education in India, Milan is joined on the show this week by Gayatri Nair Lobo, the CEO of Educate Girls. Gayatri has more than 25 years of experience across the consulting and development sectors. Before joining Educate Girls, she led the ATE Chandra Foundation and the India School Leadership Institute. She has also held senior roles at Dalberg Advisors and Teach For India.Milan and Gayatri discuss the origins of Educate Girls, the supply and demand-side barriers to girls' education, and the launch of the world's first Development Impact Bond. Plus, the two talk about the use of tools like randomized controlled trials (RCTs) and machine learning in delivering education and how to forge lasting partnerships with state governments.Episode notes:1. “A Blueprint for India's State Capacity Revolution (with Karthik Muralidharan),” Grand Tamasha, May 23, 2024.2. “Understanding the Delhi Education Experiment (with Yamini Aiyar),” Grand Tamasha, January 22, 2025.3. “How India's Women Are Redefining Politics (with Ruhi Tewari),” Grand Tamasha, November 5, 2025.4. “Rohini Nilekani on the Secret to Successful Governance,” Grand Tamasha, October 5, 2022.
Doctors Lisa and Sara speak to Consultant Neurologist Dr Antonella Macerollo about Essential Tremor (ET). We take a case and go through what ET is, how it might present, differentials and the differences between other conditions, how it might affect people and what management options there are. This is the first of two Episodes with Dr Antonella Macerollo, our next one is about Parkinson's Disease. Thanks to Alison Day at Parkison's UK for making the connection between ourselves and Antonella to make these episodes possible. You can use these podcasts as part of your CPD - we don't do certificates but they still count :) Resources: More Differentials and details of clinical assessment of Tremors: https://patient.info/doctor/history-examination/tremor-pro?utm_source=gpoptin Revisiting the assessment of tremor: clinical review. Vijiaratnam N, Wirth T and Morris HR. British Journal of General Practice 2020; 70 (701): 611-614. https://bjgp.org/content/70/701/611 Treatment for essential tremor: a systematic review and Bayesian Model-based Network Meta-analysis of RCTs. Zhang, Junjiao et al. eClinicalMedicine, Volume 77, 102889: https://www.thelancet.com/action/showCitFormats?doi=10.1016%2Fj.eclinm.2024.102889&pii=S2589-5370%2824%2900468-1 Parkinson's UK: https://www.parkinsons.org.uk/ The epidemiological link between Essential Tremor and Parkinson's Disease: https://www.nature.com/articles/s41531-023-00577-y ___ We really want to make these episodes relevant and helpful: if you have any questions or want any particular areas covered then contact us on Twitter @PCKBpodcast, or leave a comment on our quick anonymous survey here: https://pckb.org/feedback Email us at: primarycarepodcasts@gmail.com ___ This podcast has been made with the support of GP Excellence and Greater Manchester Integrated Care Board. Given that it is recorded with Greater Manchester clinicians, the information discussed may not be applicable elsewhere and it is important to consult local guidelines before making any treatment decisions. The information presented is the personal opinion of the healthcare professional interviewed and might not be representative to all clinicians. It is based on their interpretation of current best practice and guidelines when the episode was recorded. Guidelines can change; To the best of our knowledge the information in this episode is up to date as of it's release but it is the listeners responsibility to review the information and make sure it is still up to date when they listen. Dr Lisa Adams, Dr Sara MacDermott and their interviewees are not liable for any advice, investigations, course of treatment, diagnosis or any other information, services or products listeners might pursue as a result of listening to this podcast - it is the clinicians responsibility to appraise the information given and review local and national guidelines before making treatment decisions. Reliance on information provided in this podcast is solely at the listeners risk. The podcast is designed to be used by trained healthcare professionals for education only. We do not recommend these for patients or the general public and they are not to be used as a method of diagnosis, opinion, treatment or medical advice for the general public. Do not delay seeking medical advice based on the information contained in this podcast. If you have questions regarding your health or feel you may have a medical condition then promptly seek the opinion of a trained healthcare professional.
Send us a textMethods & challenges of establishing causal relationships in health research, emphasizing epidemiology, randomized trials, and genetic approaches.Topics:Epidemiology: Studies disease influences using observational designs like case-control and prospective cohorts, plus trials, to identify patterns and test hypotheses.Hierarchy of evidence critique: Rejects rigid pyramids favoring RCTs, as all studies can be biased; advocates triangulation integrating varied data types for robust conclusions.RCT strengths & weaknesses: Randomization balances confounders, but issues like poor blinding, attrition, or subversion can undermine results; large samples may yield spurious precision if biased.Confounding & reverse causation: Examples include yellow fingers and lung cancer (both from smoking) or early atherosclerosis inflating CRP-disease links; hard to fully control statistically.Nutrition epidemiology: Observational studies often overstate benefits (e.g., vitamin E for heart disease), leading to failed trials; incentives favor new findings over revisiting errors.Mendelian randomization: Uses genetic variants as proxies for exposures (e.g., ALDH2 for alcohol metabolism) to mimic randomization; reveals no heart benefits from alcohol, unlike observational data.Negative controls: Tests implausible outcomes (e.g., smoking and murder) or exposures (e.g., paternal smoking in pregnancy) to check for confounding artifacts.Evidence triangulation: Combines diverse studies with different biases (e.g., cross-cultural comparisons) for causality; applied to dismiss HDL-raising drugs despite initial promise.Practical Takeaways:Scrutinize health claims by checking for negative controls or variety in evidence sources to avoid mistaking correlation for causation.For personal decisions like alcohol intake, consider genetic studies showing risks at all levels, and aim for moderation or abstinence based on overall evidence.When evaluating supplements or diets, prioritize trials over observational data, and question media hype that ignores confounding factors.About the guest: Dr. George Davey Smith, MD, DSc is a professor of clinical epidemiology at the University of Bristol and director of the MRC Integrative Epidemiology Unit.*Not medical advice.Support the showAffiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts
Episode Overview In this episode, Dr. David Rosenblum discusses the role of supplements and complementary strategies in the management of chronic pain. Drawing from clinical practice at AABP Integrative Pain Care, as well as his teaching and training programs, Dr. Rosenblum reviews how nutraceuticals, regenerative therapies, ultrasound-guided procedures, and neuromodulation can work together to improve patient outcomes and reduce opioid reliance. This episode also highlights educational opportunities and exam-prep resources for pain fellows, residents, anesthesiologists, physiatrists, and APPs looking to expand their interventional pain, ultrasound, and regenerative medicine skill sets. Key Topics Discussed Evidence and clinical rationale for select supplements in chronic pain management The role of ultrasound guidance in improving accuracy and safety in interventional pain procedures How regenerative medicine techniques such as PRP and BMAC are shaping personalized pain care Practical considerations when combining supplements with neuromodulation, RFA, or injections Patient case applications and real-world treatment planning Educational Offerings & Learning Opportunities PainExam / NRAP Academy Training & Programs: Neuromodulation & Regional Anesthesia Workshops Ultrasound-Guided Pain Procedures Regenerative Pain Medicine Training Virtual Pain Fellowship Pain Management Board Review & Question Banks Learn More / Register: www.AABPpain.com
Send us a textWhat if the very foundation of modern care—science alone—is the problem?You see the stats: mothers are drowning in postpartum depression, crippling anxiety, and mysterious autoimmune flare-ups. You're doing the screenings, you're following the standard protocols, but the lasting solutions are elusive. What if the very foundation of modern care—science alone—is the problem? Maranda dives into the six critical limitations of medical science that are actively harming mothers in the fourth trimester. This isn't anti-science; it's a call for a more honest, holistic postpartum health model. This episode exposes the six critical limitations of medical care actively harming the fourth trimester. We break down why relying on RCTs ignores millennia of successful traditional postpartum practices. Discover the Three Pillars of Knowledge for root-cause resolution in perinatal mental health and move beyond symptom managementCheck out the episode on the blog HERE: https://postpartumu.com/podcast/the-6-critical-blind-spots-of-science-that-are-harming-postpartum-moms-ep-242/Key time stamps: 04:15: Miranda's personal story: Dismissed with Zoloft, actually had thyroid dysfunction, gut infection, and severe nutrient deficiencies.09:05: The Three Pillars of Postpartum Knowledge: Science, Women's Stories, and Traditional Practices.11:47: Limitation #1: Science is money-driven and prioritizes patentable solutions over holistic postpartum practices.16:30: Limitation #3: Dismissing millennia of traditional care (like warm, cooked foods) as mere anecdotal evidence.21:20: Limitation #4: Doctors are taught pathology, not how the body actually heals, leading to a focus on pieces instead of the whole.26:38: Limitation #5: The male bias in research and leadership and why women were historically excluded from clinical trials.31:45: Limitation #6: Time lag in policy change—it takes 10-15 years for new evidence to become standard practice.34:23: Clinical Example: Client with "medication-resistant PPD" actually had Hashimoto's and severe B12/Ferritin deficiency.36:50: Call to Action: Believe your client, investigate beyond basic labs, and hold providers accountable for outdated care.40:17: Final thought: Science alone is not enough; we need all three pillars for comprehensive, root-cause postpartum support. NEXT STEPS:
Creatine is the most researched, most effective, and most misunderstood supplement in fitness. In this episode, Vinny and Dr. Eryn break down exactly what the science says about creatine — muscle growth, strength, ATP energy regeneration, cognitive function, loading vs. maintenance dosing, safety, myths, and who actually benefits the most. We cover: • How creatine actually works to regenerate ATP • Whether timing matters (before vs. after vs. whenever) • Why most lean mass increases are intracellular water — and why that's a good thing • What 100+ randomized controlled trials and multiple meta-analyses show about strength & hypertrophy • Cognitive benefits backed by RCTs (memory, reasoning, mental clarity) • Safety in healthy adults and considerations for kidney disease • The truth about hair loss, dehydration, and “creatine is a steroid” myths If you lift weights, want to build muscle, or care about brain health — this is your guide to creatine done right. Coach Vinny Email: vinny@balancedbodies.io Instagram: vinnyrusso_balancedbodies Facebook: Vinny Russo Dr. Eryn Email: dr.eryn@balancedbodies.io Instagram: dr.eryn_balancedbodies Facebook: Eryn Stansfield LEGION 20% OFF CODE Go to https://legionathletics.com/ and use the code RUSSO for 20% off your order!
In this solo episode, Darin reframes one of the most misunderstood forces in life — stress. Instead of seeing it as the enemy, he explores how stress is actually a messenger, guiding you back to alignment, safety, and awareness. Through science, spirituality, and lived experience, Darin breaks down how stress shows us where we're trying to control, where we're disconnected, and where our nervous system is calling for attention. He unpacks the layers of modern stress — from trauma and environment to community and purpose — and offers practical, embodied tools to restore calm, clarity, and resilience. What You'll Learn 00:00:00 – Welcome to Super Life: Solutions for a Healthier Life and Better World 00:00:32 – Sponsor Spotlight: TheraSauna - Natural Healing Technologies (15% off with code Darrandai) 00:02:10 – The Super Life Podcast: Finding Contentment, Happiness, and Purpose 00:02:51 – Today's Topic: Stress - Reframing Stress as an Ally and Dashboard Light 00:04:54 – The "No Choice" Universe: Reconnecting to Infinite Possibilities 00:05:16 – The Reality of Stress: Statistics and the Impact of Chronic Stress 00:06:21 – Stress is Layered: Beyond a Single Cause, Addressing Chronic Stress 00:08:29 – Solutions for a Super Life: Safety over Calm and the Vagal Response 00:09:38 – The Inner Dialogue Layer: Trauma, Unconsciousness, and Spiritual Bypassing 00:11:47 – The Social Field Layer: Relationships, Community, and Finding Your Way Home 00:14:20 – Sponsor Spotlight: Bite Toothpaste - Sustainable, Non-Toxic Tabs (20% off with code Darin20) 00:16:35 – Creating Your Own Vision: Setting Boundaries with Media and Social Algorithms 00:17:29 – Finding Your Purpose: From Raising Children to Healing Injuries 00:18:35 – Environmental and Existential Stress Layers: Clutter, Noise, and Service 00:19:26 – Stress Load and Resiliency: Why Small Triggers Cause Blow-Ups 00:20:02 – Understanding the Dashboard Light: Acknowledging Unwillingness 00:20:35 – Safety as the Signal: Body Relaxation and Providing Inner Security 00:23:44 – Reframing Trauma: Was it the Protector You Needed at the Time? 00:25:00 – Releasing Trauma: Techniques, The Healing Code, and Waking the Tiger 00:26:06 – Finishing the Survival Response: Shaking, Crying, Screaming, and Stretching 00:26:38 – Stress as a Multiplier: Impact on Immune System, Heart, and Aging 00:28:10 – Stress Slows Repair: Inflammation, Cardiovascular Risk, and Cellular Aging 00:29:48 – The Integrative Approach: Changing Your Environments to Support Anti-Stress 00:30:07 – Actionable Stress Solutions: Circadian Rhythm, Nature, and Noise Reduction 00:30:44 – Actionable Stress Solutions: Gratitude, Conscious Breath, and Movement 00:31:32 – Energy Drains to Eliminate: Conflict, Clutter, Scrolling, and Late Caffeine 00:32:17 – Connecting to Greater Purpose: The Super Life Patreon Platform 00:32:54 – Morning/Night Questions: Letting Go, Creating, and Contributing 00:33:17 – Final Toolkit: Slow Breathing, Movement, Nature, Sauna, and Sleep 00:34:25 – The Invitation: Digging into all Layers of a Super Life on Patreon Thank You to Our Sponsors Therasage: Go to www.therasage.com and use code DARIN at checkout for 15% off Bite Toothpaste: Go to trybite.com/DARIN20 or use code DARIN20 for 20% off your first order. Find More from Darin Olien: Instagram: @darinolien Podcast: SuperLife Podcast Website: superlife.com Book: Fatal Conveniences Key Takeaway "Stress isn't your enemy — it's your compass. Every wave of tension points you back to what's asking for care, attention, and love. When you stop fighting stress and start listening to it, you don't just survive — you evolve." Bibliography (selected, peer-reviewed) Sources: Gallup Global Emotions (2024); Gallup U.S. polling (2024); APA Stress in America (2023); Natarajan et al., Lancet Digital Health (2020); Orini et al., UK Biobank (2023); Martinez et al. (2022); Leiden University (2025). Cohen S, Tyrrell DA, Smith AP. Psychological stress and susceptibility to the common cold. N Engl J Med.1991;325(9):606–612. New England Journal of Medicine Cohen S, et al. Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk. Proc Natl Acad Sci USA. 2012;109(16):5995–5999. PNAS Kiecolt-Glaser JK, et al. Slowing of wound healing by psychological stress. Lancet. 1995;346(8984):1194–1196. The Lancet Kiecolt-Glaser JK, et al. Hostile marital interactions, proinflammatory cytokine production, and wound healing.Arch Gen Psychiatry. 2005;62(12):1377–1384. JAMA Network Tawakol A, et al. Relation between resting amygdalar activity and cardiovascular events. Lancet.2017;389(10071):834–845. The Lancet Epel ES, et al. Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci USA.2004;101(49):17312–17315. PNAS McEwen BS, Stellar E. Stress and the individual: mechanisms leading to disease. Arch Intern Med.1993;153(18):2093–2101. PubMed McEwen BS, Wingfield JC. Allostasis and allostatic load. Ann N Y Acad Sci. 1998;840:33–44. PubMed Felitti VJ, et al. Relationship of childhood abuse and household dysfunction to many leading causes of death in adults (ACE Study). Am J Prev Med. 1998;14(4):245–258. AJP Mon Online Edmondson D, et al. PTSD and cardiovascular disease. Ann Behav Med. 2017;51(3):316–327. PMC Afari N, et al. Psychological trauma and functional somatic syndromes: a systematic review and meta-analysis.Psychosom Med. 2014;76(1):2–11. PMC Goyal M, et al. Meditation programs for psychological stress and well-being: a systematic review and meta-analysis. JAMA Intern Med. 2014;174(3):357–368. PMC Qiu Q, et al. Forest therapy: effects on blood pressure and salivary cortisol—a meta-analysis. Int J Environ Res Public Health. 2022;20(1):458. PMC Laukkanen T, et al. Sauna bathing and reduced fatal CVD and all-cause mortality. JAMA Intern Med.2015;175(4):542–548. JAMA Network Zureigat H, et al. Physical activity lowers CVD risk by reducing stress-related neural activity. J Am Coll Cardiol.2024;83(16):1532–1546. PMC Holt-Lunstad J, Smith TB, Layton JB. Social relationships and mortality risk: a meta-analytic review. PLoS Med.2010;7(7):e1000316. PMC Chen Y-R, Hung K-W. EMDR for PTSD: meta-analysis of RCTs. PLoS One. 2014;9(8):e103676. PLOS Hoppen TH, et al. Network/pairwise meta-analysis of PTSD psychotherapies—TF-CBT highest efficacy overall.Psychol Med. 2023;53(14):6360–6374. PubMed van der Kolk BA, et al. Yoga as an adjunctive treatment for PTSD: RCT. J Clin Psychiatry. 2014;75(6):e559–e565. PubMed Kelly U, et al. Trauma-center trauma-sensitive yoga vs CPT in women veterans: RCT. JAMA Netw Open.2023;6(11):e2342214. JAMA Network Bentley TGK, et al. Breathing practices for stress and anxiety reduction: components that matter. Behav Sci (Basel). 2023;13(9):756.
The ARRIVE Trial and the Term Breech Trial reshaped modern birth practices in ways researchers never intended. From skyrocketing inductions to the loss of vaginal breech training, these studies reveal how even “gold-standard” science can miss the human side of birth.Clara invites you to take a mindful pause: to look beyond the data, question how evidence gets translated into policy, get curious about how the research was designed, and remember that true evidence-based care must center the individual—not just the research.You'll Learn:What the ARRIVE Trial and the Term Breech Trial actually found (and what they didn't)How these studies shifted policy, practice, and training worldwideWhy over-reliance on “evidence” can erase skills, intuition, and personal choiceHow to bring mindfulness into your decision-making about induction, breech birth, or any medical recommendationWhy traditional and holistic birth practices still matter—even if they've never been studiedMindful Reflection“Mindfulness isn't about ignoring evidence—it's about pausing long enough to ask, ‘Does this research apply to me, in my body, in this context?' True evidence-based care is a dialogue between research, clinician experience, and your own wisdom.”Resources MentionedDownload Clara's Free Birth Plan Template, used at over 5,000 births.Ready for an evidence based birth class? Check out A Path to A Powerful BirthThe Birth Advocacy Toolkit is a great option for expectant parents who have already taken a class but want to make sure their preferences are heard and want evidence based information to help make their decisions. Evidence Based Birth: Evidence on the ARRIVE Trial and Elective Induction at 39 WeeksEvidence Based Birth: Evidence on Breech BirthGrobman WA, et al. Labor Induction versus Expectant Management in Low-Risk Nulliparous Women. NEJM, 2018.Evidence Based Birth: “Evidence on the ARRIVE Trial and Elective Induction at 39 Weeks.”Nethery E, et al. Obstet Gynecol, 2023. Post-ARRIVE induction impact study.Hannah ME, et al. Planned Cesarean vs Planned Vaginal Birth for Breech. Lancet, 2000.Kotaska A. BMJ, 2004. “Inappropriateness of RCTs for complex intrapartum phenomena.”Goffinet F, et al. PREMODA Study. Am J Obstet Gynecol, 2006.RCOG Green-top Guideline No. 20b (2017).ACOG Committee Opinion No. 745 (2018).SOGC No. 384 (2019).Get 20% off your first monthly subscription with NEEDED Vitamins
Episode Overview In this episode, Dr. David Rosenblum discusses the role of supplements and complementary strategies in the management of chronic pain. Drawing from clinical practice at AABP Integrative Pain Care, as well as his teaching and training programs, Dr. Rosenblum reviews how nutraceuticals, regenerative therapies, ultrasound-guided procedures, and neuromodulation can work together to improve patient outcomes and reduce opioid reliance. This episode also highlights educational opportunities and exam-prep resources for pain fellows, residents, anesthesiologists, physiatrists, and APPs looking to expand their interventional pain, ultrasound, and regenerative medicine skill sets. Key Topics Discussed Evidence and clinical rationale for select supplements in chronic pain management The role of ultrasound guidance in improving accuracy and safety in interventional pain procedures How regenerative medicine techniques such as PRP and BMAC are shaping personalized pain care Practical considerations when combining supplements with neuromodulation, RFA, or injections Patient case applications and real-world treatment planning Educational Offerings & Learning Opportunities PainExam / NRAP Academy Training & Programs: Neuromodulation & Regional Anesthesia Workshops Ultrasound-Guided Pain Procedures Regenerative Pain Medicine Training Virtual Pain Fellowship Pain Management Board Review & Question Banks Learn More / Register: www.AABPpain.com
Episode Overview In this episode, Dr. David Rosenblum discusses the role of supplements and complementary strategies in the management of chronic pain. Drawing from clinical practice at AABP Integrative Pain Care, as well as his teaching and training programs, Dr. Rosenblum reviews how nutraceuticals, regenerative therapies, ultrasound-guided procedures, and neuromodulation can work together to improve patient outcomes and reduce opioid reliance. This episode also highlights educational opportunities and exam-prep resources for pain fellows, residents, anesthesiologists, physiatrists, and APPs looking to expand their interventional pain, ultrasound, and regenerative medicine skill sets. Key Topics Discussed Evidence and clinical rationale for select supplements in chronic pain management The role of ultrasound guidance in improving accuracy and safety in interventional pain procedures How regenerative medicine techniques such as PRP and BMAC are shaping personalized pain care Practical considerations when combining supplements with neuromodulation, RFA, or injections Patient case applications and real-world treatment planning Educational Offerings & Learning Opportunities PainExam / NRAP Academy Training & Programs: Neuromodulation & Regional Anesthesia Workshops Ultrasound-Guided Pain Procedures Regenerative Pain Medicine Training Virtual Pain Fellowship Pain Management Board Review & Question Banks Learn More / Register: www.AABPpain.com
Psilocybin — the psychedelic compound in so-called “magic mushrooms” — has exploded into headlines and social media feeds. Some call it a miracle cure for depression, others dismiss it as hype. In this episode, I take a clear-eyed look at what the science really says.I'll start with Sarah's story — a young scientist whose life was turned upside down by a cycling accident and who found hope again through a psilocybin clinical trial at Johns Hopkins. Her words: “This trial changed my life.”From there, I explore:The history of psilocybin, from ancient rituals to 1960s psychiatry to today's “psychedelic renaissance.”The online buzz, where psilocybin is hyped as everything from a creativity booster to a trauma cure.The scientific evidence, from small pilot trials to the largest modern RCTs.The neuroscience, showing how psilocybin may “reset” rigid brain networks, boost plasticity, and even dampen inflammation.The risks, including panic, paranoia, and psychosis in vulnerable people.Finally, I'll share my Tools in Three so you can separate the real promise from the hype.Featured ResearchCarhart-Harris RL, et al. doi: 10.1016/S2215-0366(16)30065-Carhart-Harris RL, et al. doi: 10.1056/NEJMoa2032994Davis AK, et al. doi: 10.1001/jamapsychiatry.2020.3285Goodwin GM, et al. S 10.1056/NEJMoa2206443Additional insights from Nature Medicine (Carhart-Harris, 2021) and New Scientist on brain plasticity and inflammation.Each episode explores what's really going on inside your brain when you do the things you do — from the everyday to the extraordinary — and gives you three tools for your Super Brain kit. Sabina's books The Neuroscience of Manifesting Still Me 100 Days to a Younger Brain Beating Brain Fog Brain Gym in a BoxFollow Sabina Brennan on InstagramSupport this show http://supporter.acast.com/superbrain. Hosted on Acast. See acast.com/privacy for more information.
Right on the heels of the release of the 2025 AHA guidelines, including one on preferentially using IVs over IOs, comes two RCTs in the same edition of NEJM that compare intial attempts with IVs to IOs in out of hospital cardiac arrest. Dr Jarvis discusses these two papers while answer a listeners question, and tries to put this, and early epinephrine, into context. And he might throw in some commentary about the AHA's recommendations on mCPR and Heads Up CPR.Citations:1. Couper K, Ji C, Deakin CD, et al. A Randomized Trial of Drug Route in Out-of-Hospital Cardiac Arrest. N Engl J Med. 2025;392(4):336-348. doi:10.1056/NEJMoa24077802. Vallentin MF, Granfeldt A, Klitgaard TL, et al. Intraosseous or Intravenous Vascular Access for Out-of-Hospital Cardiac Arrest. N Engl J Med. 2025;392(4):349-360. doi:10.1056/NEJMoa2407616
Episode 205: Atopic Dermatitis Kara Willbanks (medical student) explains the definition, pathophysiology, and treatment of eczema. Dr. Arreaza adds some input about bleach baths and topical steroids. Written by Kara Willbanks, MSIV, American University of the Caribbean. Comments and edits by Hector Arreaza, MD.You are listening to Rio Bravo qWeek Podcast, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California, a UCLA-affiliated program sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. This podcast was created for educational purposes only. Visit your primary care provider for additional medical advice.October is the Eczema Awareness Month!What Is Atopic Dermatitis? Atopic dermatitis, a form of eczema, is a chronic, relapsing inflammatory skin disorder that often begins in childhood but can affect people of all ages. Other eczematous dermatoses include seborrheic dermatitis, contact dermatitis, juvenile plantar dermatosis, and stasis dermatitis. Atopic dermatitis is one of the most common skin conditions in the developed world, typically affecting up to 20% of children and 5-10% of adults. Patients usually present with severe pruritus (itchiness) and dry, inflamed patches of skin. Common sites include the face and extensor surfaces in infants, and flexural areas — like the elbows and knees — in older children and adults. Atopic dermatitis is often associated with other allergic conditions like asthma and allergic rhinitis — what we call the “atopic triad.” These conditions should also be considered when diagnosing someone with atopic dermatitis. PathophysiologyAtopic dermatitis is believed to occur due to a combination of genetic, immune, and environmental factors. A major component is a defective skin barrier, often linked to mutations in the filaggrin gene. This allows irritants, allergens, and microbes to penetrate the skin more easily, triggering inflammation.Differential DiagnosisAtopic dermatitis can sometimes mimic other skin conditions, so it's important to keep a differential in mind: -Contact dermatitis – triggered by allergens or irritants; often limited to the area of exposure but also tends to be very itchy. -Seborrheic dermatitis – greasy scales, typically on the scalp, eyebrows, and nasolabial folds -Psoriasis – well-demarcated plaques with silvery scales; sometimes found in similar areas of the body as eczema. -Tinea (fungal infections) – ring-shaped lesions with active, scaly borders -Important to note that treatment of tinea with topical steroids can make the rash much worse. -Scabies – intense itching, especially at night, with burrows between fingers. Ruling out these conditions helps guide the right treatment and prevent chronic mismanagement. As a recap our main differential diagnosis: contact dermatitis, seborrheic dermatitis, psoriasis, tinea, and scabies.The treatment cornerstone: Moisturizers The most important daily treatment for atopic dermatitis is regular moisturizing. Moisturizers repair the skin barrier, reduce water loss, and protect against irritants. They should be applied at least twice daily, ideally right after bathing while the skin is still damp (within 3 minutes is most ideal). Use greasy ointments or thick creams rather than lotions — think products with ceramides or glycerin (hydrates and protects skin). It is best to choose ointments or creams without additives, perfumes or fragrances. Greasier ointments are the preferred vessel; however, patient compliance may be less as they may be unpleasant to some.Bleach Baths For patients with frequent skin infections or severe eczema, dilute bleach baths can be a game-changer. How to do it? Use ¼ to ½ cup of household bleach in a full standard bathtub of water (about 40 gallons) and soak for 10 minutes, twice a week. This helps reduce bacterial colonization — particularly Staphylococcus aureus — which commonly worsens eczema. After the bath, pat the skin dry and immediately apply a moisturizer (within 3 minutes). Bleach baths are endorsed by the American Academy of Pediatrics and the American Academy of Dermatology as an adjunctive treatment for atopic dermatitis, especially in patients with moderate to severe disease and frequent bacterial infections, but the evidence for their efficacy is mixed, and further well-designed studies are needed.Medical Treatments-Topical corticosteroids: When moisturizers alone aren't enough, we move to anti-inflammatory therapy. Topical corticosteroids are the first-line treatment for flares. Some studies suggest that a short burst of a high-potency topical corticosteroid to rapidly control active disease, followed by a quick taper in potency, is most effective, whereas others use the lowest-potency agent thought to be needed and adjust upward only if this fails. Common steroids used are hydrocortisone (low potency), triamcinolone (medium potency), or betamethasone (high potency). -High-potency steroids should never be applied to sensitive skin like the face. With short-term use of lower-potency steroids, there is a low likelihood of skin atrophy but use for more than 6 months is linked with greater levels of skin thinning -Wet wrap therapy: Wet wrap therapy improves absorption of topic steroid. Apply a topical steroid, then layer a wet dressing and then a dry dressing over the top of that. This can be beneficial in providing both relief of symptoms and prevention of itching. In pediatric patients it is called “daddy's socks therapy” because large socks may be used to cover the arms of kids.-Topical calcineurin inhibitors — like tacrolimus — are great alternatives for sensitive areas or for maintenance once inflammation is under control. They may burn upon application which can scare patients away from their use.-PO antihistamines can help with itching, especially at night, but they don't treat inflammation itself.-Systemic therapies, like dupilumab (Dupixent®), an IL-4 receptor antagonist, are reserved for moderate to severe cases unresponsive to topical therapy. This is a great time to refer to your local dermatologist for management! Many of the newer treatments are highly effective but can require more frequent monitoring.Recent Research One recent study is the 2024 Cochrane network meta-analysis comparing effectiveness of topical anti-inflammatory treatments for eczema that was recently published in the AFP Journal in July of 2025.Here are the highlights:-Over 291 RCTs with ~45,846 participants were included. -The analysis ranked potent topical corticosteroids, JAK inhibitors (for example ruxolitinib (Opzelura® 1.5 %), and tacrolimus 0.1 % among the most effective for reducing signs and symptoms of eczema. -In contrast, PDE-4 inhibitors [like crisaborole (Eucrisa®) 2 %] were among the least effective in this comparison. -Regarding side effects: tacrolimus and crisaborole were more likely to cause burning or stinging at the application site; corticosteroids were less likely in the short term to cause local irritation.-Long-term outcomes regarding effectiveness or safety of treatments for eczema were not addressed by the review because they are rarely reported.”-Another insight from this study is considering cost when initiating treatment. Most topical steroids are significantly more cost effective than JAK inhibitors or calcineurin inhibitors so it may be best to start with a cheaper solution in an uninsured patient considering their relative effectiveness. Additional Tips & Lifestyle -Keep baths and showers short and in lukewarm water.-Avoid harsh soaps and detergents — use gentle, fragrance-free cleansers.-Wear soft cotton clothing instead of wool or synthetics.-Identify and avoid triggers — common ones include stress, sweating, allergens, and certain foods (especially in kids).-Ice packs can help reduce itching and relieve any burning sensation.-Keep fingernails short, especially in children, help cause less trauma to the skin from repeated itching. Living with eczema Many celebrities like Kerry Washington, Jessica Simpson, Kelly Rowland, Brad Pitt and Kristen Bell have spoken out about their lives with eczema. They have shared personal stories about how they were diagnosed, what treatment works for them, and the general impact it has had on their lives and mental health. I feel like it can be so important for celebrities to speak out about their lives with certain conditions because it helps to normalize the condition, raise awareness of the struggles, and encourages more open dialogue.It is important to remember that for patients living with eczema, the persistent itch-scratch cycle can be very distressing, causing patients to struggle with their sleep and day-to-day activities. Anxiety and depression are common in patients with eczema so as physicians it is vital to monitor for signs of distress. Support groups can be incredibly helpful for patients [National Eczema Association]If you are interested in providing additional information to your patients or getting this for yourself, you can find more resources on altogethereczema.org or nationaleczema.org. Key Takeaways Atopic dermatitis is chronic but manageable. Moisturizers are the foundation of treatment. Topical steroids and calcineurin inhibitors control inflammation. Bleach baths help reduce bacterial load and flare severity. Always rule out other skin conditions to ensure appropriate management. Atopic dermatitis can be managed by the primary care physician but in certain cases (cases refractory to standard topical treatment, recurrent infections, etc.), a referral to dermatology can be especially helpful.Even without trying, every night you go to bed a little wiser. Thanks for listening to Rio Bravo qWeek Podcast. We want to hear from you, send us an email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week! References:Coping with eczema. Allergy & Asthma Network. (2025, May 20). https://allergyasthmanetwork.org/what-is-eczema/coping-with-eczema/.Eichenfield LF, Tom WL, Chamlin SL, et al. Guidelines of care for the management of atopic dermatitis: section 1. Diagnosis and assessment of atopic dermatitis. J Am Acad Dermatol. 2014 Feb;70(2):338-51. doi: 10.1016/j.jaad.2013.10.010. Epub 2013 Nov 27. PMID: 24290431; PMCID: PMC4410183. https://pubmed.ncbi.nlm.nih.gov/24290431/.Yancey, J. R., & Green, S. (2025, July 15). Effectiveness of topical anti-inflammatory drugs for eczema. American Family Physician. https://www.aafp.org/pubs/afp/issues/2025/0700/cochrane-eczema.html.Theme song, Works All The Time by Dominik Schwarzer, YouTube ID: CUBDNERZU8HXUHBS, purchased from https://www.premiumbeat.com/.
Evidence-based policy. Randomised Control Trials or RCTs. These are buzzwords in developmental policy these days. They have become almost synonymous with each other. The ‘evidence' in ‘evidence-based' has largely come to mean whatever data is produced by one method of research – RCTs. But as some economists have been trying to tell us, RCTs have their limits. Regardless of whether it is RCTs, or some other research methodology, is it wise to let so-called ‘evidence' be the sole arbiter of public policy? What are the ways in which ‘evidence-based' approaches can go wrong, and how have RCTs ended up being misused, resulting in actual harm? Guest: Professor Jean Drèze, Development Economist Host: G Sampath Recorded, edited, and produced by Jude Francis Weston Learn more about your ad choices. Visit megaphone.fm/adchoices
Send us a textVisit my websiteCan a positive mindset truly improve your health—or even help you beat disease? In this episode, Dr. Bobby and guest Sean McDevitt explore the evidence behind optimism, visualization, and prayer to uncover what really works.In today's episode of Live Long and Well, Dr. Bobby is joined by fitness and life coach Sean McDevitt to explore whether positive thinking can influence health outcomes. They dive into both anecdotal and clinical evidence, starting with sports psychology and then navigating the science behind mindset and disease. The conversation opens with laughter and smiles—literally. Inspired by Norman Cousins' Anatomy of an Illness, Dr. Bobby references a meta-analysis showing genuine smiling does, in fact, temporarily boost happiness, while artificial smiling (like holding a pen in your mouth) doesn't.They begin with sports, where 86 studies show that visualizing athletic success can improve performance in agility, strength, and game-specific skills. Next, they ask a deeper question: does having a positive attitude affect the progression of serious disease? A meta-analysis of 26 studies on life satisfaction and longevity suggests happy people may live longer—especially when it comes to heart health. Optimism, for instance, was linked to a 35% reduction in cardiovascular events and a 15% decrease in all-cause mortality.However, when it comes to cancer, the picture gets murkier. A review of 165 studies links stress to poorer survival, but a separate meta-analysis on coping styles found no consistent impact on recurrence or survival. One influential study on breast cancer patients even found that while helplessness predicted worse outcomes, having a “fighting spirit” made no significant difference (source). As Dr. Bobby notes, it's important not to burden patients with guilt if they can't “stay positive.”The critical question becomes: if you're not naturally optimistic, can you cultivate positivity—and will it help? Encouragingly, several intervention studies suggest it might. One trial showed cardiac markers improved after optimism training, and a meta-analysis of 56 RCTs found a 15% boost in immune function after psychological interventions. A small MS study linked mindfulness to better walking ability, and a large RCT on breast cancer showed a 45% drop in recurrence with stress-reduction and mood-enhancing strategies.Finally, the episode touches on spirituality. While many find comfort in prayer, evidence from an RCT of 800 ICU patients and a [meta-analysis] shows no significant impac
What if the fastest way to change your life isn't more willpower—but a better doorway into your subconscious?On today's Crackin' Backs Podcast, hypnotherapist Dayana Muzinek (Grace Method™ certified) pulls back the curtain on how hypnotherapy works, why it's more than “stage hypnosis,” and how focused consciousness can help rewire cue–craving–response patterns that drive anxiety, insomnia, IBS/gut issues, chronic pain, vaping, and doom-scrolling. Dayana breaks down her go-to Grace Method flow—from induction to suggestion to post-session homework—and gives listeners a 90-second at-home interrupt (breath + word cue + micro-move) you can use the moment worry blindsides you. (Grace Method training details here.We also go where the clicks are:Sleep hypnosis & insomnia: What a three-step sleep hypnosis stack looks like, where hypnosis helps, and where the evidence is still emerging. (Peer-reviewed reviews/meta-analyses suggest promise but mixed methodology.Gut-directed hypnotherapy (IBS): Why clinicians are calling GDH “guideline-adjacent” and how sessions may reset the gut–brain axis; plus a calm-the-gut script outline to try at home for a week. (Multiple meta-analyses and RCTs show improvements in global IBS symptoms.Chronic pain: Where hypnosis fits best (often as an adjunct), and which levers matter most—expectations, imagery, and self-hypnosis between visits. (Recent meta-analytic work supports benefits across mental and somatic outcomes.Modern habits & identity change: From vaping to doom-scrolling to GLP-1 era weight loss, Dayana explains how hypnosis supports pre/during/post-GLP-1 phases by targeting the two identity shifts that sustain new behavior.Safety & ethics: We tackle myths about false memories and outline Dayana's trauma-sensitive, evidence-based guardrails, including the safe boundary for self-hypnosis at home.If you've ever searched “Does hypnosis really work for anxiety?”, “sleep hypnosis for insomnia,” “hypnotherapy for IBS,” or “how to break bad habits with hypnosis,” this conversation gives you science, structure, and a starter routine you can use tonight.Learn More / Book with DayanaConnect with Dayana Muzinek (LinkedIn): She's a Grace Method™ Certified Hypnotherapist and active member of IACT. Message her directly for session inquiries and availability.About the Grace Method™ (school, approach, app): Training, philosophy, and consumer resources.We are two sports chiropractors, seeking knowledge from some of the best resources in the world of health. From our perspective, health is more than just “Crackin Backs” but a deep dive into physical, mental, and nutritional well-being philosophies. Join us as we talk to some of the greatest minds and discover some of the most incredible gems you can use to maintain a higher level of health. Crackin Backs Podcast
Fitness mit M.A.R.K. — Dein Nackt Gut Aussehen Podcast übers Abnehmen, Muskelaufbau und Motivation
Starre Ernährungspläne sehen auf dem Papier gut aus, halten dem Kontakt mit dem "echten Leben" aber oft nicht stand. Am Ende dieser Folge weißt Du, wie Du trotzdem gewinnst.Du erfährst, warum rigide Kontrolle oft zu Stress, Rückfällen und Jo-Jo-Effekt führt, während flexible Kontrolle nachweislich mit weniger Überessen, niedrigerem BMI und besserer Stimmung einhergeht.Statt Verboten bekommst Du ein praxistaugliches System: 90/10-Prinzip, kleine Hebel für jede Mahlzeit und ein Umfeld, das Dich trägt, statt Deine Willenskraft zu verbrauchen.Dabei gehen wir ganz praktisch vor. Es geht um Leitplanken, die Dir Freiheit geben und die zu Deinem Alltag passen, ohne Abwiegen und Tabellen.Marks Ziel: Am Ende der Folge hast Du einen kompakten Werkzeugkasten in der Tasche, der Dir das Dranbleiben leicht(er) macht.____________*WERBUNG: Infos zum Werbepartner dieser Folge und allen weiteren Werbepartnern findest Du hier.____________Mehr zum Thema:Das erwähnte „Buch-Geheimprojekt“: Mehr dazu im Newsletter, sobald es spruchreif ist.Artikel: Das 90/10 PrinzipErnährungs-App (Tipp): Yazio ProLiteratur:Wing, et al. (2005). Long‑term weight loss maintenance. Am J Clin Nutr, 82(1 Suppl), 222S–225S.Anderson, et al. (2001). Long‑term weight‑loss maintenance: A meta‑analysis of US studies. Am J Clin Nutr, 74(5), 579–584.Dombrowski, et al. (2014). Long term maintenance of weight loss with non‑surgical interventions in obese adults: Systematic review and meta‑analyses of RCTs. BMJ, 348, g2646.Westenhoefer, et al. (2013). Cognitive and weight‑related correlates of flexible and rigid restrained eating behaviour. Eating Behaviors, 14(1), 69–72.Hollands, et al. (2015). Portion, package or tableware size for changing selection and consumption of food, alcohol and tobacco. Cochrane Database Syst Rev, 2015(9), CD011045.Robinson, et al. (2014). A systematic review and meta‑analysis examining the effect of eating rate on energy intake and hunger. Am J Clin Nutr, 100(1), 123–151.Carrière, et al. (2018). Mindfulness‑based interventions for weight loss: A systematic review and meta‑analysis. Obes Rev, 19(2), 164–177.Teixeira, et al. (2012). Motivation, self‑determination, and long‑term weight control. Int J Behav Nutr Phys Act, 9, 22.Lally, et al. (2010). How are habits formed? Modelling habit formation in the real world. Eur J Soc Psychol, 40(6), 998–1009.Westerterp‑Plantenga, et al. (2009). Dietary protein, weight loss, and weight maintenance. Annu Rev Nutr, 29, 21–41.Robinson, et al. (2022). Calorie‑reformulation: A systematic review and meta‑analysis examining the effect that manipulating food energy density has on daily energy intake. Int J Behav Nutr Phys Act, 19, 48.Hall, et al. (2019). Ultra‑processed diets cause excess calorie intake and weight gain: An inpatient randomized controlled trial of ad libitum food intake. Cell Metab, 30(1), 67–77.e3.Mills, et al. (2017). Frequency of eating home‑cooked meals and potential benefits for diet and health: Cross‑sectional analysis of a population‑based cohort study. Int J Behav Nutr Phys Act, 14, 109.Larson, et al. (2006). Food preparation by young adults is associated with better diet quality. J Am Diet Assoc, 106(12), 2001–2007.____________Shownotes und Übersicht aller Folgen.Trag Dich in Marks Dranbleiber Newsletter ein.Entdecke Marks Bücher.Folge Mark auf Instagram, Facebook, Strava, LinkedIn. Hosted on Acast. See acast.com/privacy for more information.
Nick Tiller returns to discuss whether saunas actually have health benefits and possibly completely contradict himself after his previous episode about ice baths. We dig into the data from Kuopio and the Finnish Kuopio Ischemic Heart Disease Risk Factor study and investigate whether there might be some risks associated with saunas. Become a supporter of our show today either on Patreon or through PayPal! Thank you! http://www.patreon.com/thebodyofevidence/ https://www.paypal.com/donate?hosted_button_id=9QZET78JZWCZE Email us your questions at thebodyofevidence@gmail.com. Editor: Robyn Flynn Theme music: “Fall of the Ocean Queen“ by Joseph Hackl Rod of Asclepius designed by Kamil J. Przybos Chris' book, Does Coffee Cause Cancer?: https://ecwpress.com/products/does-coffee-cause-cancer Obviously, Chris is not your doctor (probably). This podcast is not medical advice for you; it is what we call information. References: 1) Nick's Skeptical Inquirer article on the subject of saunas: https://skepticalinquirer.org/exclusive/are-saunas-good-for-you-yes-but/ 2) The study purporting to show a 60% benefit in cardiovascular risk https://www.tandfonline.com/doi/10.1080/07853890.2017.1387927#d1e290 3) A scientific review of the health benefits of sauns from the same authors: https://www.sciencedirect.com/science/article/pii/S0025619623000083 4) One of the few RCTs on the issue although it only uses surrogate endpoints: https://journals.physiology.org/doi/full/10.1152/japplphysiol.00322.2023
Stress isn't just something to “manage” — it's a signal, a teacher, and often, an invitation to look deeper at our health, our choices, and our lives. In this solo episode, Darin reframes stress not as an enemy, but as a dashboard light pointing toward misalignments in our nervous system, environment, relationships, and purpose. Drawing on science, practical tools, and personal insight, Darin reveals how layered stress silently drains our vitality — and how to transform it into an ally for growth, healing, and deeper contentment. Whether it's hidden trauma, toxic environments, unresolved conflict, or the modern distractions constantly pulling at our attention, Darin lays out a roadmap to stop the leaks and reclaim the energy already within you. This episode is a powerful reminder: stress isn't the end of the story — it's the beginning of awareness, safety, and a super life. What You'll Learn in This Episode [00:00] Introduction to the Super Life podcast [03:27] Why stress might not be your enemy [04:17] Stress as an ally: the signals it gives us about misalignment [04:32] The dashboard light metaphor: how stress reveals hidden issues [05:28] The illusion of “no choice” and the infinite possibilities always available [06:12] Global stress statistics and why most people underestimate their stress load [07:23] Hidden stress revealed through heart rate variability and physiology [08:23] Layered stress: how sleep, exercise, and poor choices compound each other [09:25] Safety vs. calm — why your nervous system craves safety first [10:15] Trauma and the unconscious mind: how old wounds drive our stress response [11:54] Inner narratives and negative self-talk as hidden stress multipliers [12:22] The role of community and your social field in stress and resilience [13:53] Relationships, honesty, and how your circle shapes your energy [14:55] Why boundaries around media and politics are vital for mental clarity [17:42] Finding micro-purpose when life feels overwhelming [18:52] Environmental layers of stress — light, air, and clutter [19:15] The existential layer: stress from living without service or purpose [20:12] Stress as a risk amplifier — how it undermines healing and health [20:55] The deeper truth of safety, connection, and higher power [23:00] Practical tools: breathing, grounding, nature, and conscious choices [24:01] Trauma reframed: not a problem, but a protector at the time [25:25] Lessons from Peter Levine and wild animals: releasing trauma physically [26:04] Questions to ask trauma: “What are you protecting me from?” [26:56] Stress as a multiplier of aging, disease, and poor outcomes [29:20] Why stress isn't a single cause — it's layered and chronic [30:18] Anti-stress strategies: circadian rhythm, nature, and gratitude [31:49] Energy leaks to avoid: clutter, poor food, scrolling, bad boundaries [32:22] What matters most: service, contribution, and alignment [33:28] Final toolkit: breathwork, movement, nature, sleep, and gratitude [34:38] The deeper invitation: step into sovereignty and live your SuperLife Thank You to Our Sponsors: Manna Vitality: Go to mannavitality.com/ or use code DARIN20 for 20% off your order. Bite Toothpaste: Go to trybite.com/DARIN20 or use code DARIN20 for 20% off your first order. Find More from Darin Olien: Instagram: @darinolien Podcast: SuperLife Podcast Website: superlife.com Book: Fatal Conveniences Check out my podcast with Dr. Amy Abbington Key Takeaway “Stress is not the enemy. It's a dashboard light — a teacher showing you where you're out of alignment. When you reframe stress, you reclaim your energy and create space for healing, safety, and the joy of living a super life.” Bibliography (selected, peer-reviewed) Sources: Gallup Global Emotions (2024); Gallup U.S. polling (2024); APA Stress in America (2023); Natarajan et al., Lancet Digital Health (2020); Orini et al., UK Biobank (2023); Martinez et al. (2022); Leiden University (2025). Cohen S, Tyrrell DA, Smith AP. Psychological stress and susceptibility to the common cold. N Engl J Med.1991;325(9):606–612. New England Journal of Medicine Cohen S, et al. Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk. Proc Natl Acad Sci USA. 2012;109(16):5995–5999. PNAS Kiecolt-Glaser JK, et al. Slowing of wound healing by psychological stress. Lancet. 1995;346(8984):1194–1196. The Lancet Kiecolt-Glaser JK, et al. Hostile marital interactions, proinflammatory cytokine production, and wound healing.Arch Gen Psychiatry. 2005;62(12):1377–1384. JAMA Network Tawakol A, et al. Relation between resting amygdalar activity and cardiovascular events. Lancet.2017;389(10071):834–845. The Lancet Epel ES, et al. Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci USA.2004;101(49):17312–17315. PNAS McEwen BS, Stellar E. Stress and the individual: mechanisms leading to disease. Arch Intern Med.1993;153(18):2093–2101. PubMed McEwen BS, Wingfield JC. Allostasis and allostatic load. Ann N Y Acad Sci. 1998;840:33–44. PubMed Felitti VJ, et al. Relationship of childhood abuse and household dysfunction to many leading causes of death in adults (ACE Study). Am J Prev Med. 1998;14(4):245–258. AJP Mon Online Edmondson D, et al. PTSD and cardiovascular disease. Ann Behav Med. 2017;51(3):316–327. PMC Afari N, et al. Psychological trauma and functional somatic syndromes: a systematic review and meta-analysis.Psychosom Med. 2014;76(1):2–11. PMC Goyal M, et al. Meditation programs for psychological stress and well-being: a systematic review and meta-analysis. JAMA Intern Med. 2014;174(3):357–368. PMC Qiu Q, et al. Forest therapy: effects on blood pressure and salivary cortisol—a meta-analysis. Int J Environ Res Public Health. 2022;20(1):458. PMC Laukkanen T, et al. Sauna bathing and reduced fatal CVD and all-cause mortality. JAMA Intern Med.2015;175(4):542–548. JAMA Network Zureigat H, et al. Physical activity lowers CVD risk by reducing stress-related neural activity. J Am Coll Cardiol.2024;83(16):1532–1546. PMC Holt-Lunstad J, Smith TB, Layton JB. Social relationships and mortality risk: a meta-analytic review. PLoS Med.2010;7(7):e1000316. PMC Chen Y-R, Hung K-W. EMDR for PTSD: meta-analysis of RCTs. PLoS One. 2014;9(8):e103676. PLOS Hoppen TH, et al. Network/pairwise meta-analysis of PTSD psychotherapies—TF-CBT highest efficacy overall.Psychol Med. 2023;53(14):6360–6374. PubMed van der Kolk BA, et al. Yoga as an adjunctive treatment for PTSD: RCT. J Clin Psychiatry. 2014;75(6):e559–e565. PubMed Kelly U, et al. Trauma-center trauma-sensitive yoga vs CPT in women veterans: RCT. JAMA Netw Open.2023;6(11):e2342214. JAMA Network Bentley TGK, et al. Breathing practices for stress and anxiety reduction: components that matter. Behav Sci (Basel). 2023;13(9):756.
Back pain is one of the most common health problems in the world — but also one of the most mysterious. Scans don't always match symptoms, treatments don't always provide relief, and many people feel stuck with ongoing discomfort.In this episode, I explore chronic, non-specific low back pain through a biopsychosocial lens. Basically, we're looking beyond just the spine to understand how biology, psychology, and environment all shape the way pain is experienced.You'll hear about:What makes non-specific low back pain so puzzlingHow pain perception actually works (pain ≠ tissue damage)Why the biopsychosocial model is key to understanding painThe role of self-regulation in shaping pain responsesWhat research says about meditation for back painHow to reframe back pain when you feel like you're hitting a wallJournal prompts to reflect on your own experienceBy the end, you'll have a new way to think about back pain, one that expands the options for healing beyond the body alone.Engel, G. L. (1977). The need for a new medical model: a challenge for biomedicine. Science, 196(4286), 129–136. (Origin of the biopsychosocial model)Study on self-regulation and pain: Wager, T. D., et al. (2013). An fMRI-based neurologic signature of physical pain. New England Journal of Medicine, 368(15), 1388–1397. (and related follow-up studies on cognitive self-regulation impacting autonomic markers — you summarised one in your notes)Systematic review on meditation and back pain: Cramer, H., et al. (2022). Meditation for adults with non-specific low back pain: a systematic review and meta-analysis. (Included 8 RCTs, ~1,234 participants, moderate-certainty evidence of small benefits for disability and long-term pain
Dr. Chad Kollas has spent more than two decades challenging myths and misinformation about opioids in pain care. In this episode, he joins us to break down the FDA's latest opioid label changes, explain why they matter for patients, and share his perspective as a palliative care physician who has been on the frontlines of this debate since the early 2000s.We talk about:The significance of the FDA's new opioid labelThe ethical failures of randomized controlled trials (RCTs) in pain patientsHow propaganda has shaped the narrative around opioidsWhat patients and providers need to know moving forwardIf you've ever wondered how we got here and what hope there is for change you won't want to miss this conversation.Dr. Chad Kollas' study: https://pmc.ncbi.nlm.nih.gov/articles/PMC10790545/
In this episode, Drs Trexler and Helms discuss various topics including updates on Eric's surgery, the valuable (but very modest) effects of protein intake on muscle gains, incontinence after contest prep, the relationship between sleep quality and nutrient timing, the recent ban on smelling salts in the NFL, and more. Time stamps: 00:00 Introduction 01:11 Preview of next week's episode (non-responders, hyper-responders, etc) 07:01 Trex's surgery update 12:11 Discussion on Protein Meta-Analyses and Research Updates (how much does protein intake actually matter for gains?) 33:10 Why meta-analyses differ from RCTs in terms of "expiration dates" 44:15 The Impact of Training vs. Nutrition (for muscle growth) 51:41 Q&A: Supplementation for Lifters (and Specifically Vegans Who Lift) 55:49 Incontinence, Increased Urine Output, and Contest Prep 59:16 Chrono Nutrition and Sleep Quality 01:11:28 The Role of Smelling Salts in Sports Performance (and Football)
In this episode of Iron Culture, Dr. Eric Helms talks about his forthcoming article in the MASS Research Review covering the purported harms of high-protein diets. This isn't your typical oversimplified dunk-fest that readily dismisses concerns about high-protein diets. Instead, Helms reviews a thorough paper that reviews common concerns in detail and assessed their plausibility in an objective manner. The claims include: Claim 1 – protein reduces lifespan Claim 2 – protein makes bones weaker Claim 3 – protein harms kidneys Claim 4 – protein causes diabetes After that, Dr. Eric Trexler discusses a recent Instagram thread that pulled him into arguments against his will. The post was about his recent article on ketogenic diets and seed oils – two topics that are always bound to attract some controversy and heated debate. This conversation discusses the strengths and limitations of different types of scientific research and also touches on bias, objectivity, and the process of seeking the truth with an open mind. Time stamps: 0:00 Intro 3:00 Helms' new article about the purported harms of high-protein diets 19:25 Claim 1 – protein reduces lifespan 27:48 Claim 2 – protein makes bones weaker 43:38 Claim 3 – protein harms kidneys 50:53 Claim 4 – protein causes diabetes 57:22 Trex's social media beefs – keto and seed oils 1:03:40 Types of observational studies 1:08:35 Seeking truth versus defending biases 1:17:32 Limitations versus fatal flaws 1:24:19 Limitations of RCTs (randomized controlled trials) 1:32:23 Wrapping up
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