Podcasts about Sequencing

In genetics and biochemistry, determining the structure of an unbranched biopolymer

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Best podcasts about Sequencing

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Latest podcast episodes about Sequencing

On the Mark Golf Podcast
Building an Athletic Golf Swing with Milo Lines

On the Mark Golf Podcast

Play Episode Listen Later Oct 27, 2025 54:51


Milo Lines is a PGA Professional, a Golf Digest "Best Teacher in State," and a former Tour Professional. His philosophy on the golf swing is that there is crossover, especially in sports involving hitting and throwing, with golf and the golf swing.  As a teacher his goal is to apply the athletic skills you already have and teach you the skills you need in order to improve as a golfer.  He joins #OntheMark to help you apply your athletic instinct and experiences to make your golf swing more athletic and effective. Milo shares his "5 Key Elements" to an athletic approach to the golf swing: ALIGNING - Grip, Aim and Alignment SEQUENCING - Swing Triggers, Timing, Rhythm and Tempo WINDING - Turning and Tilting athletically LOADING - The Athletic approach to the Transition and Change of Direction UNLEASHING - The Automatic Release of the club thanks to proper Sequencing, Winding and Loading. Milo also illustrates PGA TOUR examples such as Lee Trevino and Jack Nicklaus as athletic swing models, and teaches you a Drill (Laddering) that will improve your practice and unleash your inner athlete. This podcast is also available as a vodcast on YouTube.  Search and subscribe to Mark Immelman.

Real Money Talks
What Are the Most Effective Wealth Building Strategies?

Real Money Talks

Play Episode Listen Later Oct 24, 2025 39:23


In this episode, Loral Langemeier joins John Casmon to share her most powerful wealth building strategies and lessons from a remarkable career that began on a Nebraska farm and led to becoming “The Millionaire Maker.” From working with Bob Proctor and the Rich Dad Poor Dad team to authoring six bestselling books, Loral explains how mentorship, sequencing, and mindset create sustainable wealth.Through real stories, she breaks down the myths that keep people stuck, including the false belief that you must be debt-free before you can grow. Instead, she explains why doing the right thing at the right time and surrounding yourself with the right mentors can fast-track results.Whether you're transitioning from a 9-to-5, investing in real estate, or starting your first business, this conversation is packed with actionable wealth building strategies that help you think, act, and build like a millionaire.Loral's Takeaways:Loral Langemeier's Background and Early Career (00:00)Transition to Real Estate and Becoming a Millionaire Maker (02:39)The Importance of Mentorship and Team Building (11:06)Sequencing and Financial Strategy (17:35)Overcoming Challenges and Achieving Success (30:27)Connect with John Casmon:https://casmoncapital.com/https://www.linkedin.com/in/multifamily-apartments-john-casmon/https://www.instagram.com/jcasmon/?hl=enMeet Loral Langemeier:Loral Langemeier is a money expert, sought-after speaker, entrepreneurial thought leader, and best-selling author of five books.Her goal: to change the conversations people have about money worldwide and empower people to become millionaires.The CEO and Founder of Live Out Loud, Inc. – a multinational organization — Loral relentlessly and candidly shares her best advice without hesitation or apology. What sets her apart from other wealth experts is her innate ability to recognize and acknowledge the skills & talents of people, inspiring them to generate wealth.She has created, nurtured, and perfected a 3-5 year strategy to make millions for the “Average Jill and Joe.” To date, she and her team have served thousands of individuals worldwide and created hundreds of millionaires through wealth-building education keynotes, workshops, products, events, programs, and coaching services.Loral is truly dedicated to helping men and women, from all walks of life, to become millionaires AND be able to enjoy time with their families.She is living proof that anyone can have the life of their dreams through hard work, persistence, and getting things done in the face of opposition. As a single mother of two children, she is redefining the possibility for women to have it all and raise their children in an entrepreneurial and financially literate environment. Links and Resources:Ask Loral App: https://apple.co/3eIgGcXLoral on Facebook: https://www.facebook.com/askloral/Loral on YouTube: https://www.youtube.com/user/lorallive/videosLoral on LinkedIn:

BackTable Urology
Ep. 267 Sequencing Therapies in NMIBC Management with Dr. Mark Tyson and Dr. Suzanne Merrill

BackTable Urology

Play Episode Listen Later Oct 21, 2025 59:51


New FDA-approved therapies for BCG-refractory non-muscle invasive bladder cancer (NMIBC)–where do they fit in the treatment algorithm, and how do you administer them? This installment of the 2025 NMIBC Creator Weekend™ series features host Dr. Bogdana Schmidt, assistant professor of Urologic Oncology at the University of Utah, and leading urologic oncologists Dr. Mark Tyson from Mayo Clinic Arizona and Dr. Suzanne Merrill from Colorado Urology.---This podcast is supported by:Ferring Pharmaceuticalshttps://www.ferring.com/home-classic/people-and-families/uro-uro-oncology/bladder-cancer/---SYNPOSISThe discussion delves into the newest treatment strategies and FDA-approved therapies for non-muscle invasive bladder cancer with an emphasis on BCG-refractory patients. They highlight their approaches to sequencing therapies, the real-world applicability of these treatments, and the impact of patient factors in clinical decision-making. The panel also explores emerging trials and innovative treatment mechanisms, emphasizing the importance of personalized care in oncology.---TIMESTAMPS00:00 - Introduction05:09 - Challenges and Strategies in Treatment10:55 - Bladder Sparing Therapies21:41 - Practical Tips for Therapy Administration30:39 - Challenges and Considerations in Reinduction37:05 - Clinical Trials and Future Directions44:11 - Counseling Patients on Treatment Options57:36 - Concluding Thoughts and Future Outlook---RESOURCESCORE-008 Clinical Trial https://www.sciencedirect.com/science/article/abs/pii/S1078143924010147Legend Clinical Trial:https://ascopubs.org/doi/10.1200/JCO.2025.43.5_suppl.802CISTO Studyhttps://pubmed.ncbi.nlm.nih.gov/37980511/

Yogaland Podcast
Sequencing 2.0: Think Beyond the One-Off Class with Jason Crandell

Yogaland Podcast

Play Episode Listen Later Oct 16, 2025 51:16


This week -- a solocast from Jason, fresh from his trip teaching a weeklong "Sequencing 2.0" training in London. On this episode, he breaks down a practical framework for scaling a single 60-minute sequence into:(1) shorter online formats(2) longer workshops(3) four-week series with clear objectivesHe also explains why real creativity comes from solving for a goal—not from random choreography—and how to communicate a simple plan so students feel part of something bigger. Psst! Don't miss next week's episode where we launch a four-part “Transformation Series,” that follows three of Jason's trainees through their teacher training journey. Hosted on Acast. See acast.com/privacy for more information.

Concrete Logic
EP #136: Concrete Profit — 7 Ways Ready-Mix Producers Can Stop Losing Money

Concrete Logic

Play Episode Listen Later Oct 16, 2025 34:33 Transcription Available


What if the problem isn't your concrete, but how you run your business? In this episode of the Concrete Logic Podcast, Seth Tandett talks with Tamson Omps, Director of Operations at Thomas Concrete, about how ready-mix producers can finally take control of their margins. Tamson lays out the seven areas that make or break profitability in the ready-mix business—from equipment maintenance and driver retention to scheduling and waste management. Whether you manage a single plant or oversee a regional operation, this episode gives you a practical, no-nonsense look at what's actually driving your profits (and losses) today. What You'll Learn • Why does Tamson say “we don't sell concrete—we sell truck space”? • What simple maintenance strategy can save thousands in downtime? • How can ready-mix companies cut driver turnover by focusing on the right incentives? • What's the real cost of a truck sitting on the jobsite? • How does batching setup and admixture sequencing impact load times and profit? • What can schedulers do to eliminate wasted hours in the yard? • How can waste and return concrete be turned into an extra revenue stream? Chapters 00:00 – Introduction: The Profitability Puzzle in Ready-Mix 01:19 – Shifting Perspective: Concrete as a Service, Not a Product 03:25 – Low Hanging Fruit: Equipment Maintenance 04:36 – People Matter: Keeping Delivery Pros on the Team 08:20 – Truck Turnaround: The Real KPI That Matters 11:02 – Load Times and Plant Flow: Admixtures, Sequencing, and Efficiency 18:16 – Scheduling for Success: Managing Peak Demand 22:54 – Waste Management: Turning Returns into Revenue Guest Info Tamson Omps Director of Operations, Thomas Concrete Email: tamson.omps@thomasconcrete.com LinkedIn: https://www.linkedin.com/in/tamson-omps-mba/ Company: Thomas Concrete – https://www.thomasconcrete.com Concrete Logic Academy Earn PDHs the easy way. Listen to podcast episodes, complete a short quiz, and get professional development hours with proper documentation. Start your free trial: https://www.concretelogicacademy.com Support the Podcast This show runs on a Value-for-Value model. If you got value from this episode, consider supporting us: https://www.concretelogicpodcast.com/donate Support the show while gearing up with KUIU premium outdoor gear—what Seth wears both on the hunt and on the job. Shop through this link at no extra cost: https://www.concretelogicpodcast.com/KUIU Want help with media services like podcasting or YouTube for your concrete company? Reach out to Seth at seth@concretelogicpodcast.com. Credits Producers: Jodi Tandett and Concrete Logic Media Music by Mike Dunton – https://www.mdunton.com Connectivity Host: Seth Tandett – Concrete Visionary & Business Development Manager at Baker Construction LinkedIn: https://www.linkedin.com/in/sethtandett YouTube: https://www.youtube.com/@concretelogicpodcast Website: https://www.concretelogicpodcast.com Don't forget to like, subscribe, comment, and share. Let's keep it concrete.

The Perfect Stool Understanding and Healing the Gut Microbiome
Rethinking Antimicrobials: Protecting the Microbiome in Clinical Practice with Dr. Brad Leech, PhD

The Perfect Stool Understanding and Healing the Gut Microbiome

Play Episode Listen Later Oct 14, 2025 63:27


 Ever wondered if your gut health protocols are truly helping, or possibly harming, your microbiome? Join Lindsey Parsons and Dr. Brad Leech as they unpack the latest science on antimicrobials, microbiome testing, leaky gut, low stomach acid, prebiotics and more. Discover when to use certain interventions, how to protect your beneficial bacteria, and which strategies really make a difference based on the research. Lindsey Parsons, your host, helps clients solve gut issues and reverse autoimmune disease naturally. Take her quiz to see which stool or functional medicine test will help you find out what's wrong. She's a Certified Health Coach at High Desert Health in Tucson, Arizona. She coaches clients locally and nationwide. You can also follow Lindsey on Facebook, Tiktok, X, Instagram or Pinterest or reach her via email at lindsey@highdeserthealthcoaching.com to set up your free 30-minute Gut Healing Breakthrough Session. Show Notes

Research To Practice | Oncology Videos
Breast Cancer | HR-Positive and Triple-Negative Metastatic Breast Cancer — An Interview with Dr Laura Huppert on Optimal Integration of ADCs into Treatment (Companion Faculty Lecture)

Research To Practice | Oncology Videos

Play Episode Listen Later Oct 11, 2025 31:09


Featuring a slide presentation and related discussion from Dr Laura Huppert, including the following topics: Overview of approved antibody-drug conjugates (ADCs) for metastatic hormone receptor-positive HER2-negative breast cancer — trastuzumab deruxtecan, sacituzumab govitecan and datopotamab deruxtecan(0:00) Approved and investigational ADCs for metastatic triple-negative breast cancer (17:18) Sequencing of ADCs for metastatic HER2-negative breast cancer; future research directions (26:10) CME information and select publications

Optimal Health For Busy Entrepreneurs
289. The Benefits of Hyperbaric Oxygen Therapy For Business Leaders with Dr. Jason Sonners

Optimal Health For Busy Entrepreneurs

Play Episode Listen Later Oct 10, 2025 62:53


In this episode of Executive Health & Life, host Julian Hayes II sits down with Dr. Jason Sonners, a leading expert in Hyperbaric Oxygen Therapy (HBOT), to explore how this cutting-edge modality can help executives, entrepreneurs, and high performers improve their recovery, mental clarity, and longevity.Dr. Sonners explains the science behind HBOT, how it supports cellular repair and mitochondrial functioning, and why it's fast becoming a go-to strategy for business leaders who want to extend their peak years. You'll learn how to use oxygen therapy for energy, focus, inflammation control, and overall resilience.— Episode Chapter Big Ideas (timing may not be exact) —0:00 – Welcome & why health freedom drew Dr. Sonners to Miami05:45 – How a PhD in molecular biology deepened his work in regenerative medicine09:40 – What Hyperbaric Oxygen Therapy actually is, and what it's not14:30 – The back injury that led Dr. Sonners to discover HBOT20:45 – The science: oxygen pressure, healing, and energy production25:10 – HBOT for longevity: inflammation, mitochondria, and aging31:00 – How often to use HBOT and how to structure your sessions35:20 – Oxygen toxicity myths and how to choose a certified clinic40:10 – Stacking HBOT with red light, methylene blue, NAD, and cold exposure46:30 – Sequencing your recovery and performance plan49:30 – HBOT's link to gene expression and biological aging55:00 – Miami's rise as a wellness capital1:00:00 – Final reflections on patience, consistency, and sovereignty in health— Key Quotes from Dr. Jason Sonners — “Oxygen isn't the treatment—it's the ingredient. Hyperbaric oxygen therapy simply gives your body what it needs to heal itself.”“Your body already knows how to recover. HBOT just removes the barriers that keep it from doing what it's designed to do.”— Connect With Dr. Jason Sonners —Website: https://hbotusa.com/ Instagram: https://www.instagram.com/hbotusa/ YouTube: https://www.youtube.com/@HBOTUSA Book - Oxygen Under Pressure: https://www.amazon.com/Oxygen-Under-Pressure-Inflammation-Revolutionize/dp/1661251358/ — Connect with Julian and Executive Health —LinkedIn — https://www.linkedin.com/in/julianhayesii/Ready to take your health, leadership, and performance to the next level? Book a complimentary private executive health diagnostic call with Julian Hayes II. Link below. https://calendly.com/julian-exechealth/chemistryWebsite — https://www.executivehealth.io/***DISCLAIMER: The information shared is not meant to treat or diagnose any condition. This is for educational, informational, and entertainment purposes. The content here is not intended to replace your relationship with your doctor and/or medical practitioner.

Changing Higher Ed
Executing a Debt-Free Higher Education Turnaround with Real Estate

Changing Higher Ed

Play Episode Listen Later Oct 7, 2025 25:24


When every board discussion centers on deficits, deferred maintenance, or another “strategic realignment,” higher education leaders start asking what it would take to fix the system instead of just managing decline. In this episode of the Changing Higher Ed® podcast, Dr. Drumm McNaughton speaks with Beth Martin, President of Notre Dame de Namur University (NDNU), who led her institution through a complete financial and operational turnaround—eliminating institutional debt through strategic real estate use, risk planning, and sound financial governance. Martin's experience offers a rare look at what it takes to execute a true higher education turnaround. She shares how NDNU's leadership aligned governance, mission, and financial strategy to not only survive but rebuild a sustainable model focused on graduate and online growth. This conversation is especially relevant for presidents, trustees, CFOs, and institutional leaders facing financial strain, considering asset monetization, or preparing for large-scale organizational change. Topics Covered: How NDNU executed a debt-free turnaround through real estate strategy and risk planning Applying business planning and systems theory to higher education transformation Managing institutional debt while investing in academic and technological infrastructure Governance structures that enable speed, trust, and accountability during turnaround Aligning presidents, boards, and sponsoring orders in complex financial transactions Leading cultural and organizational change while maintaining mission and morale Real-World Examples Discussed: NDNU's 46-acre land transaction that retired institutional debt and funded new programs Sequencing real estate sales to support strategy instead of short-term survival Governance reform guided by a skills matrix and board-chair alignment Realigning academic programs around graduate and online learning Faculty and staff engagement during institutional transition Three Key Takeaways for Leadership: Treat land monetization as strategy, not salvage. Link every major financial decision to a defined business plan and measurable outcomes. Integrate business and risk planning into every turnaround. Build contingencies for timing, regulation, and accreditation challenges. Strengthen governance alignment. A unified president and board chair, supported by a skills-based board, determine turnaround success. Read the transcript: https://changinghighered.com/debt-free-higher-education-turnaround-strategy-real-estate/ #HigherEdLeadership #HigherEdTurnaround   #HigherEducationPodcast

OncLive® On Air
S14 Ep25: Sequencing, Efficacy, and Safety Data May Further Evolve the Role of Fruquintinib in CRC: With Kanwal P. S. Raghav, MBBS, MD

OncLive® On Air

Play Episode Listen Later Oct 6, 2025 9:26


In today's episode, we had the pleasure of speaking with Kanwal P. S. Raghav, MBBS, MD, about the role of fruquintinib (Fruzaqla) in the treatment of adult patients with pretreated, metastatic colorectal cancer (CRC). Dr Raghav is a professor in the Department of Gastrointestinal Medical Oncology in the Division of Cancer Medicine, associate vice president of the Department of Ambulatory Medical Operations, and executive medical director of the Department of Ambulatory Treatment Centers at The University of Texas MD Anderson Cancer Center in Houston. In our exclusive interview, Dr Raghav discussed the mechanism of action of fruquintinib, key efficacy data from the phase 3 FRESCO (NCT02314819) and FRESCO-2 (NCT04322539) trials, the treatment settings where this agent is most frequently administered, and adverse effects to be aware of. He also noted how the role of fruquintinib in earlier lines of therapy has yet to be defined due to a lack of optimal predictive biomarkers. Dr Raghav concluded by emphasizing the importance of clinical trials for improving outcomes for patient with CRC.

Joe DeFranco's Industrial Strength Show
#541 When To Program Slow Eccentrics, Exercise Sequencing for Better Joint Health & More!

Joe DeFranco's Industrial Strength Show

Play Episode Listen Later Oct 2, 2025 86:00


This week Joe is solo and he's answering 4 of YOUR questions! Specific topics include: 1) Is eccentric duration important for muscle hypertrophy? (If not, is there EVER a reason to intentionally slow down the eccentric portion of the lift?) 2) What NOT to do [training-wise] if you're looking to build muscle and strength 3) Are glucose monitors beneficial for non-diabetics? Should we be concerned about "insulin spikes" when trying to drop body fat? 4) The best way to sequence exercises for joint health (on a PPL split)...And MORE! *For a full list of Show Notes + Timestamps visit www.IndustrialStrengthShow.com IMPORTANT LINKS DeFranco's Nutritional Supplements Team Forever Strong [FREE Trial] Joe's most viral IG post Pain-Free Dip technique

Joe DeFranco's Industrial Strength Show
#541 When To Program Slow Eccentrics, Exercise Sequencing for Better Joint Health & More!

Joe DeFranco's Industrial Strength Show

Play Episode Listen Later Oct 2, 2025 86:00


This week Joe is solo and he's answering 4 of YOUR questions! Specific topics include: 1) Is eccentric duration important for muscle hypertrophy? (If not, is there EVER a reason to intentionally slow down the eccentric portion of the lift?) 2) What NOT to do [training-wise] if you're looking to build muscle and strength 3) Are glucose monitors beneficial for non-diabetics? Should we be concerned about "insulin spikes" when trying to drop body fat? 4) The best way to sequence exercises for joint health (on a PPL split)...And MORE! *For a full list of Show Notes + Timestamps visit www.IndustrialStrengthShow.com IMPORTANT LINKS DeFranco's Nutritional Supplements Team Forever Strong [FREE Trial] Joe's most viral IG post Pain-Free Dip technique

Brain Driven Brands
When to Use % Off vs. $ Off Discounts

Brain Driven Brands

Play Episode Listen Later Oct 2, 2025 20:35


We dropped a stat this week that stopped Nate in his tracks: brands can see up to 42% more sales just by framing discounts the right way. No new ads, no extra products...just choosing percent off vs. dollar off at the right moment. In Episode 105, we dig into the psychology behind that lift and why most brands blow Q4 by overcomplicating offers, stacking promos, and teaching customers not to trust them. Inside the conversation:  ✅ The science behind when to use % off vs. $ off (and why it changes sitewide vs. single product) ✅ The 5 offer types we see every year — and which ones are worth your testing budget ✅ Why “combo deals” and “sale extended” emails wreck trust long-term ✅ Sequencing tactics (like Nate's “Better Than Black Friday” play) that build urgency without burning credibility ✅ Why sometimes the boldest Q4 strategy is raising prices, not cutting them If you've ever wondered: 1. How to simplify offers so customers don't need a calculator 2. Why half-off deals aren't always the flex you think they are 3. How to build trust during the most profitable month of the year 4. And why less discounting can actually mean more margin …this one's for you. Season 3 keeps pushing, and the data's spicy.

This Is Horror Podcast
TIH 633: Josh Malerman on Watching Evil Dead, Unearthing the Radiant Artist Within, and Sequencing Book Order Like an Album

This Is Horror Podcast

Play Episode Listen Later Oct 1, 2025 70:37


In this podcast, Josh Malerman talks about his brand new book, Watching Evil Dead, unearthing the radiant artist within, sequencing book order like an album, and much more. About Josh Malerman Josh Malerman is an American novelist, short story writer, film producer, and one of two singer/songwriters for the rock band The High Strung. He … Continue reading

Up To Date
Kansas City's Children's Mercy Hospital debuts a new way of sequencing genes

Up To Date

Play Episode Listen Later Sep 29, 2025 17:53


Dr. Tomi Pastinen, director of Genomic Answers for Kids, led the first clinical study of five-base long read sequencing, recently published in the Journal of the American Medical Association Pediatrics. This new method shows doctors more of the genome and can diagnose rare diseases with a single test.

Physician's Weekly Podcast
HER2+ Horizons: Episode 2: Sequencing After Progression—What Comes Next?

Physician's Weekly Podcast

Play Episode Listen Later Sep 24, 2025 9:59


In this episode, Sara Tolaney, MD, of Dana-Farber Cancer Institute, discusses sequencing strategies after progression in...

Physician's Weekly Podcast
HER2+ Horizons: Episode 2: Sequencing After Progression—What Comes Next?

Physician's Weekly Podcast

Play Episode Listen Later Sep 24, 2025 9:59


In this episode, Sara Tolaney, MD, of Dana-Farber Cancer Institute, discusses sequencing strategies after progression in HER2-positive metastatic breast cancer. She reviews current second-line standards, considerations for patients with brain metastases, and emerging therapies in the post–T-DXd setting.Let us know what you thought of this week's episode on Twitter: @physicianswkly Want to share your medical expertise, research, or unique experience in medicine on the PW podcast? Email us at editorial@physweekly.com! Thanks for listening!

Elite Baseball Development Podcast
212. Spencer Stockton on Hypermobility, Sequencing, and Leveraging Data vs. "Feel"

Elite Baseball Development Podcast

Play Episode Listen Later Sep 23, 2025 47:19


In this episode, Cressey Sports Performance - Florida pitching coach Spencer Stockton covers a wide variety of topics. Spencer reflects on the training and mechanical cues that benefited him the most as a hypermobile pitcher. Taking it a step further, he digs in on the power of motion capture technology, and coaching with a combination of data and "feel."Support Our Sponsor: AG1

Research To Practice | Oncology Videos
Oncology Nursing Update: Multiple Myeloma — An Interview with Dr Beth Faiman on CAR T-Cell Therapy

Research To Practice | Oncology Videos

Play Episode Listen Later Sep 20, 2025 52:48


Featuring an interview with Dr Beth Faiman, including the following topics: Clinical practice background and historical view of treatment for multiple myeloma (MM) (0:00) Fundamental principles associated with chimeric antigen receptor (CAR) T-cell therapy (7:19) Sequencing of CAR T-cell therapy and bispecific antibodies in the MM treatment landscape (9:00) Patient eligibility to receive CAR T-cell therapy (13:23) Differentiating among approved CAR T-cell therapies for MM (18:18) Durability of responses to CAR T-cell therapy for MM (24:01) Neurotoxicity with CAR T-cell therapies for MM (26:26) Minimal residual disease monitoring in MM (29:39) Support systems for the management of toxicities associated with CAR T-cell therapy (35:10) Patients with MM experiencing durable responses to CAR T-cell therapy (43:11) NCPD information and select publications

Breast Cancer Update
Metastatic Triple-Negative Breast Cancer — The Selection and Sequencing of Therapy

Breast Cancer Update

Play Episode Listen Later Sep 18, 2025 58:41


Dr Ana C Garrido-Castro and Prof Peter Schmid review patient cases and provide insights regarding the treatment of metastatic triple-negative breast cancer. CME information and select publications here.

Research To Practice | Oncology Videos
Metastatic Triple-Negative Breast Cancer — The Selection and Sequencing of Therapy

Research To Practice | Oncology Videos

Play Episode Listen Later Sep 17, 2025 58:42


Featuring perspectives from Dr Ana C Garrido-Castro and Prof Peter Schmid, including the following topics:  Introduction: Legendary Figures in Breast Cancer Research (0:00) Case: A woman in her early 80s, a current smoker with a history of myocardial infarction and stroke, who develops recurrent triple-negative breast cancer (TNBC) — Justin Favaro, MD, PhD (6:44) Case: A woman in her late 60s with metastatic TNBC and a PD-L1 level of 20% who receives chemotherapy/pembrolizumab followed by sacituzumab govitecan — Priya Rudolph, MD, PhD (25:08) Case: A woman in her late 60s with localized TNBC who develops myocarditis while receiving neoadjuvant chemotherapy/pembrolizumab — Richard Zelkowitz, MD (33:53) Case: A woman in her mid 60s with recurrent ER-negative, HER2-low, PI3K-mutant TNBC — Ranju Gupta, MD (37:49) Case: A woman in her early 60s with recurrent TNBC confined to contralateral neck nodes — Eric H Lee, MD, PhD (42:10) Case: A woman in her early 40s with metastatic TNBC who receives sacituzumab govitecan after multiple lines of chemotherapy — Estelamari Rodriguez, MD, MPH (48:10) Case: A woman in her mid 70s with ER-negative, HER2-low breast cancer who develops an isolated brain metastasis — Dr Gupta (55:02) CME information and select publications

Nurse Educator Tips for Teaching
Simulation Sequencing

Nurse Educator Tips for Teaching

Play Episode Listen Later Sep 17, 2025 18:06


Standards for simulated patient encounters have been developed; however, the sequencing of simulation experiences has not been well-established. Sequencing purposefully manipulates the order of nursing content delivery including didactic, simulation, and clinical practice. Limited research has prevented the development of sequencing standards that may improve student learning. Learn more about simulation sequencing in this podcast with Brandy Falconer and the few studies that have been done.

SHEA
Stewardship of Metagenomic Sequencing

SHEA

Play Episode Listen Later Sep 15, 2025 24:55


In this episode of The SHEA Podcast, Dr. Katie Chiotos (Children's Hospital of Philadelphia) and Dr. Trevor Van Schooneveld (University of Nebraska Medical Center) discuss the stewardship of metagenomic sequencing (mNGS) in infectious disease care. They explore how to make results clinically actionable, avoid overuse or misinterpretation, and integrate mNGS into stewardship and infection prevention programs. The conversation also looks ahead to the future of mNGS and the role stewardship leaders will play in guiding its responsible use.

Oncology Brothers
Treating and Managing Chronic Lymphocytic Leukemia (CLL) in 2025: Dr. Mazyar Shadman

Oncology Brothers

Play Episode Listen Later Sep 11, 2025 24:34


Join us for an insightful episode as we dive deep into the evolving landscape of Chronic Lymphocytic Leukemia (CLL) treatment. This episode features Dr. Mazyar Shadman, an expert in lymphoid malignancies from the Fred Hutch Cancer Center. In this episode, we covered: • The importance of shared decision-making in CLL treatment. • When to initiate treatment for newly diagnosed CLL patients. • The role of time-limited venetoclax-based regimens versus continuous BTK inhibitors. • Key considerations in choosing the right BTK inhibitor and managing side effects. • The relevance of minimal residual disease (MRD) in treatment duration. • Sequencing strategies for relapsed and refractory CLL, including the use of Pirtobrutinib and CAR-T therapy. Whether you're a healthcare professional or someone interested in the latest advancements in oncology, this episode is packed with valuable insights and practical advice. Don't forget to like, subscribe, and leave us your feedback! Your support helps us bring these important discussions to a wider audience. Tune in now and stay informed about the latest in CLL treatment! Follow us on social media: •⁠  ⁠X/Twitter: https://twitter.com/oncbrothers •⁠  ⁠Instagram: https://www.instagram.com/oncbrothers •⁠  Website: https://oncbrothers.com/ #Ibrutinib #acalabrutinib #zanubrutinib #Pirtobrutinib #CLL2025 #BTKinhibitors #Venetoclax #MRDnegative #OncologyBrothers

Journal of the American Society of Nephrology (JASN)
RNA Sequencing of IgA Nephropathy Kidneys

Journal of the American Society of Nephrology (JASN)

Play Episode Listen Later Sep 10, 2025 23:25 Transcription Available


Drs. Anna Levin and Annika Wernerson discuss the findings from their study, "Transcriptomic Patterns in Adult and Pediatric Patients with IgA Nephropathy or IgA Vasculitis with Nephropathy," with JASN Deputy Editor David H. Ellison.

Project Oncology®
Refining Multimodal Therapy for Mesothelioma: Clinical Impact of SMART Sequencing

Project Oncology®

Play Episode Listen Later Sep 9, 2025


Guest: John Cho, MD, PhD, FRCPC Surgery for mesothelioma after radiation therapy (SMART) offers new hope for patients with resectable epithelioid mesothelioma by reversing the traditional treatment sequence. Hear from Dr. John Cho as he discusses the rationale behind this decade-long clinical advancement, which he spoke about at the 2025 World Conference on Lung Cancer. Dr. Cho is a radiation oncologist at Princess Margaret Cancer Centre and an Associate Professor in the Department of Radiation Oncology at the University of Toronto.

Project Oncology®
Unlocking Tumor Complexity: Single-Cell RNA Sequencing in Lung Cancer

Project Oncology®

Play Episode Listen Later Sep 9, 2025


Guest: Paola Marignani, PhD, EMBA Single-cell RNA sequencing is transforming our understanding of tumor heterogeneity in primary lung cancers by offering insights far beyond traditional bulk sequencing. In this program, Dr. Paola Marignani explores how advanced machine learning enables faster, more precise profiling of genetic diversity, predictive modeling for recurrence and drug resistance, and personalized treatment strategies. Dr. Marignani is a Professor in the Department of Biochemistry and Molecular Biology at Dalhousie University in Halifax, Novia Scotia, and she spoke about this topic at the 2025 World Conference on Lung Cancer.

ADHD Experts Podcast
571- Combined Treatment Options for Pediatric ADHD: Sequencing Your Child's Care

ADHD Experts Podcast

Play Episode Listen Later Sep 2, 2025 59:19


Mark A. Stein, Ph.D., will provide an overview of pediatric ADHD treatment options, explain why it's crucial to personalize treatment, and how to combine and sequence medication and other treatments for optimal care. ADHD Treatments for Children: Additional Resources Free Download: Take Charge of Your Child's Medication Read: ADHD Treatment Options for Children Read: What Is Complex ADHD? Symptoms, Diagnosis & Treatment Read: How a Physician Treats ADHD with Combination Therapy Access the video and slides for podcast episode #571 here: https://www.additudemag.com/webinar/adhd-treatment-options-combination-therapy/ This episode is sponsored by the podcast Hyperfocus with Rae Jacobson. Search for “Hyperfocus with Rae Jacobson” in your podcast app or find links to listen at https://lnk.to/hyperfocusPS!adhdexperts. This episode is also brought to you by Brain.fm. Unlock your brain's full potential FREE for 30 days by going to brain.fm/ADDITUDE. Thank you for listening to ADDitude's ADHD Experts podcast. Please consider subscribing to the magazine (additu.de/subscribe) to support our mission of providing ADHD education and support.

Research To Practice | Oncology Videos
Breast Cancer — 5-Minute Journal Club Issue 2 with Dr Erika Hamilton: Defining the Role of TROP2-Directed Antibody-Drug Conjugates

Research To Practice | Oncology Videos

Play Episode Listen Later Sep 1, 2025 15:43


Featuring an interview with Dr Erika Hamilton, including the following topics: Monitoring, mitigating and managing adverse events with antibody-drug conjugates (ADCs) for breast cancer (0:00) Heist RS et al. Clinical management, monitoring, and prophylaxis of adverse events of special interest associated with datopotamab deruxtecan. Cancer Treat Rev 2024;125:102720. Abstract Management protocols for adverse events associated with sacituzumab govitecan (7:49) García JMP et al. Prevention of sacituzumab govitecan (SG)-related neutropenia and diarrhea in patients with triple-negative or HR+/HER2- advanced breast cancer (ABC; PRIMED): A phase 2 trial. ASCO 2024;Abstract 1101. Pérez-García JM et al. Prevention of sacituzumab govitecan-related neutropenia and diarrhea in patients with HER2-negative advanced breast cancer (PRIMED): An open-label, single-arm, phase 2 trial. eClinicalMedicine 2025;85:103309. Abstract Datopotamab deruxtecan for patients with breast cancer brain metastases or leptomeningeal disease (10:51) Tarantino P et al. DATO-Base: A phase II study of DATOpotamab deruxtecan for patients with breast cancer brain metastases or leptomeningeal disease. ASCO 2025;Abstract TPS1134. Sequencing ADCs in breast cancer (13:12) Pacholczak-Madej R et al. Sequencing of antibody drug conjugates in breast cancer: Evidence gap and future directions. Biochim Biophys Acta Rev Cancer 2025;[Online ahead of print]. Abstract CME information and select publications

Category Visionaries
How Starboard uses door-to-door prospecting with donuts to win freight forwarder clients | Sumeet Trehan ($5.5M Raised)

Category Visionaries

Play Episode Listen Later Aug 29, 2025 24:17


Starboard is building AI-first infrastructure to transform global trade by improving the productivity of freight forwarders—the central coordinators who connect 15-20 different parties in every international trade transaction. With 15 years of experience in the industry, including roles at Maersk, BCG, and Flexport, Sumeet Trehan saw an opportunity to modernize an industry that has invested heavily in physical infrastructure but neglected technological innovation. The company has raised $5.5 million and is approaching $1 million ARR while creating an entirely new category they call "AI-first forwarders." Topics Discussed: Building AI infrastructure to automate freight forwarding coordination and quoting processes Creating a new category in the traditional, relationship-driven logistics industry Go-to-market strategies for selling to an "old boys club" industry that operates differently from typical SaaS markets The founder's decision to personally handle the first 20-30 sales before hiring any sales staff Vision for transforming global trade by creating a comprehensive platform for small-to-mid-sized importers   GTM Lessons For B2B Founders: Cold calling still works in traditional industries: Starboard generates significant top-of-funnel activity through direct cold calling, with freight forwarders actually appreciating the personal touch. Sumeet's team achieves a 10% pickup rate and converts 15-20% of answered calls to discovery meetings by being upfront about the cold call nature and immediately focusing on business outcomes. The approach works because their target market—freight forwarders—are accustomed to making and receiving cold calls as part of their daily business operations. Door-to-door prospecting remains viable for relationship-driven markets: In industries where personal relationships dominate, physical presence can be a differentiator. Starboard literally brings donuts to prospects' offices, which works because their target market values face-to-face interactions. This approach only makes sense when your industry culture supports it and when the lifetime value of customers justifies the time investment. Founders should personally execute early sales to understand the playbook: Rather than immediately hiring sales staff after raising funding, Sumeet chose to personally close the first 20-30 deals. This allowed him to deeply understand customer pain points, refine the sales process, and develop a replicable methodology before bringing on sales team members. Only after proving out the top-of-funnel motion did he hire his first SDR, and only after closing 15-20 deals did he hire a sales leader. Physical implementation presence drives early-stage product adoption: For complex B2B products still achieving product-market fit, being physically present during implementation creates stronger relationships and better feedback loops. Starboard's team travels to be on-site when clients first use the product, which helps with both adoption rates and product development insights. They maintain ongoing communication through WhatsApp and Teams channels rather than Slack, adapting to their customers' preferred communication methods. Category creation requires education over product promotion: Starboard's marketing strategy focuses entirely on educating the market about AI's potential impact on logistics rather than promoting their specific product. By speaking at events, writing blogs, and participating in podcasts about industry transformation rather than Starboard features, they position themselves as thought leaders. This approach builds trust and creates demand for the category before potential customers are ready to evaluate specific solutions. Sequencing product development based on customer feedback: The company's current quoting product serves as a wedge, with plans to expand into marketplace functionality and then full operations automation. Each expansion builds on customer relationships and data from the previous phase. This measured approach to product development ensures each step creates value while building toward the larger vision of comprehensive trade infrastructure.   //   Sponsors: Front Lines — We help B2B tech companies launch, manage, and grow podcasts that drive demand, awareness, and thought leadership. www.FrontLines.io The Global Talent Co. — We help tech startups find, vet, hire, pay, and retain amazing marketing talent that costs 50-70% less than the US & Europe.  www.GlobalTalent.co   //   Don't Miss: New Podcast Series — How I Hire Senior GTM leaders share the tactical hiring frameworks they use to build winning revenue teams. Hosted by Andy Mowat, who scaled 4 unicorns from $10M to $100M+ ARR and launched Whispered to help executives find their next role. Subscribe here: https://open.spotify.com/show/53yCHlPfLSMFimtv0riPyM 

The Funny Thing About Yoga
Q&A: Specific Sequencing Requirements & What To Do About Moaners

The Funny Thing About Yoga

Play Episode Listen Later Aug 28, 2025 28:00


In this juicy bonus Q&A episode, we kick things off with banter about East Coast Italian-American pride, Bradshaw's first Italian adventure, and our surprising discovery of supri- Rhode Island's beloved cured pork specialty. Then we dive into listener questions: the nitty-gritty of sequencing requirements and what to do when a distracting moaner in class sparks complaints. We explore how sequencing rules can feel limiting but also inspire creativity, and how one moaner story sends Giana spiraling into a tangent about a farter—navigating complaints, boundaries, and those unavoidable uncomfortable conversations.SEND YOUR QUESTIONS TO: CAYAYOGASCHOOL@GMAIL.COM

Science (Video)
A Closer Look at…Genetic Medicine and Artificial Intelligence

Science (Video)

Play Episode Listen Later Aug 19, 2025 57:59


AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]

Health and Medicine (Video)
A Closer Look at…Genetic Medicine and Artificial Intelligence

Health and Medicine (Video)

Play Episode Listen Later Aug 19, 2025 57:59


AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]

University of California Audio Podcasts (Audio)
A Closer Look at…Genetic Medicine and Artificial Intelligence

University of California Audio Podcasts (Audio)

Play Episode Listen Later Aug 19, 2025 57:59


AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]

Health and Medicine (Audio)
A Closer Look at…Genetic Medicine and Artificial Intelligence

Health and Medicine (Audio)

Play Episode Listen Later Aug 19, 2025 57:59


AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]

Science (Audio)
A Closer Look at…Genetic Medicine and Artificial Intelligence

Science (Audio)

Play Episode Listen Later Aug 19, 2025 57:59


AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]

Healing through Pain
Episode 280 - Sequencing for Anxiety Reduction

Healing through Pain

Play Episode Listen Later Aug 18, 2025 18:21


It takes intentional effort to put things into helpful sequencing. When we take time to do it, though, it can push back against anxiety in significant ways!

The Strategy Skills Podcast: Management Consulting | Strategy, Operations & Implementation | Critical Thinking
576: Bain Senior Partner Sarah Elk on Doing Agile Right (Strategy Skills classics)

The Strategy Skills Podcast: Management Consulting | Strategy, Operations & Implementation | Critical Thinking

Play Episode Listen Later Aug 11, 2025 61:38


Sarah Elk, Senior Partner at Bain & Company and global leader of its operating model work, brings a clear, pragmatic lens to why so many large-scale change efforts fail to stick. Drawing on decades of advising multinational organizations, she diagnoses the structural and behavioral traps that cause transformations to stall, and shares the disciplines that make change durable.   Elk emphasizes that transformation is not a one-off program but an enduring capability that must be “led from the top and embedded in the culture.” She cautions against outsourcing responsibility to a program office: “If the CEO is not leading it and the leadership team isn't engaged in the change, you might get something done, but it will erode quickly.”   Key Insights from the Conversation: Clarity on Non-Negotiables Many failed transformations lack a shared definition of the “non-negotiables” in the new operating model. Without them, execution becomes fragmented. “You have to be crystal clear on what's standard and what's flexible.”   Outcomes Over Activity Successful change efforts anchor to measurable business results, not just activity metrics or generic benchmarks. “It's not about hitting 80 percent of a checklist. It's about whether you've moved the needle on the outcomes you care about.”   Leadership Alignment Is a Continuous Process Alignment isn't built in a single offsite; it requires ongoing dialogue, joint problem-solving, and confronting decisions that challenge entrenched interests. “You need the leadership team acting as one—every week, every month—not just at the kickoff.”   Manage Change Fatigue Overloading the organization erodes momentum. Sequencing initiatives and celebrating visible early wins tied to strategy helps sustain energy. “People get tired. You have to show progress and give them space to breathe.”   Governance, Incentives, and Talent Must Evolve Together Elk warns that without parallel changes to systems and structures, “behavior will revert to what it was before.”   The discussion reframes transformation from a high-profile event into a muscle organizations must build and maintain. For executives seeking change that endures beyond the initial push, Elk offers a blueprint grounded in operational rigor, leadership accountability, and cultural realism.   Get Sarah's book here: https://shorturl.at/Tyotz Doing Agile Right: Transformation Without Chaos   Here are some free gifts for you: Overall Approach Used in Well-Managed Strategy Studies free download: www.firmsconsulting.com/OverallApproach   McKinsey & BCG winning resume free download: www.firmsconsulting.com/resumepdf   Enjoying this episode? Get access to sample advanced training episodes here: www.firmsconsulting.com/promo

Alloutcoach Tim
GOLD MEDAL EDGE IN SPORTS PERFORMANCE WITH GENOMICS AND GUT MICROBIOME

Alloutcoach Tim

Play Episode Listen Later Aug 10, 2025 37:49


Watch my first-ever conversation with a political leader on the Alloutcoach show who has also transcended business, entrepreneurship, community service, women's rights advocacy and sports science. This episode uncovers a personal story and manifestation of character and integrity of an inspiring, dynamic, and powerful leader, Hon. Leela Aheer, former Canadian Minister of Culture, Multiculturalism, and Women's rights, musician, and activist throughout her journey of transformation into becoming a business executive, entrepreneur and expert in optimizing athletic performance.In addition to lessons on sportsmanship-centered leadership in business, you will discover the difference precision medicine with multi-omics and slightest variance in our microbiome DNA can have on creating gold medalists in sports, and champions in health, training, rehabilitation and recovery.

The Funny Thing About Yoga
Q&A: When a Student Asks You Out & Monthly Sequencing Strategy

The Funny Thing About Yoga

Play Episode Listen Later Aug 1, 2025 24:43


In this juicy bonus Q&A episode, we tackle two big topics: what to do when a student asks you out (yep, it happens) and how to approach sequencing for an entire month without losing your mind. Along the way, our banter takes a few detours, including what it's like navigating an unequal partnership, the emotional weight of Bradshaw's first retreat after his dad's death, disassociating vs. Pratyahara, and other behind-the-scenes info. It's raw, real, and a little ridiculous, just how we like it.SEND YOUR QUESTIONS TO: CAYAYOGASCHOOL@GMAIL.COM

The Consistency Project
Five Minute Answers: Food Sequencing & Women's Cardio Myths, Plus Biohacker BS

The Consistency Project

Play Episode Listen Later Jul 30, 2025 29:54


We're unpacking common myths around food sequencing, exercise, and nutrition for women, while addressing listener questions about dietary advice and fitness practices. You'll gain insights into the complexities of weight loss, the importance of cardiovascular exercise, and the real impact of food order on your health.

The ICHE Podcast
Episode 60: Plasma Cell-Free DNA and Metagenomic Sequencing in Infectious Disease Diagnosis

The ICHE Podcast

Play Episode Listen Later Jul 24, 2025 42:07


In this episode of The ICHE Podcast, we take a deep dive into the evolving role of plasma cell-free DNA (cfDNA) metagenomic next-generation sequencing (mNGS) in the diagnosis of infectious diseases. Hosted by experts from UCLA Health, this discussion breaks down what cfDNA mNGS is, how it differs from more traditional pathogen detection tools like PCR, and where it fits in the diagnostic landscape. Dr. Ishminder Kaur, Dr. Daniel Uslan, and Dr. Shangxin Yang join the episode to explore the clinical utility, benefits, and pitfalls of this rapidly emerging diagnostic modality. The group reviews several individual studies, highlighting how they approached their research questions, key findings, and the implications for patient care and antimicrobial stewardship. The conversation also addresses challenges such as interpreting complex results, cost considerations, and potential overuse. Whether you're a clinician, laboratorian, or infection preventionist, this episode provides critical insights into when and how cfDNA mNGS may enhance your diagnostic toolkit—and when it might not. Each guest closes with a practical takeaway: concrete advice for healthcare professionals who are considering incorporating cfDNA testing into their own clinical or infection control practice.

Round Table China
Have you tried meal sequencing?

Round Table China

Play Episode Listen Later Jul 23, 2025 22:43


Forget 'you are what you eat.' The real game-changer? How you eat it. Science says tweaking just one thing about your meals—no willpower required—could dial up your focus, steady your mood, and keep your blood sugar in check. There is a downside though. It may make eating a little annoying. / AI pet short dramas (16:07). On the show: Steve Hatherly, Niu Honglin & Yushun

Research To Practice | Oncology Videos
Chronic Lymphocytic Leukemia — Proceedings from a Webinar Held in Conjunction with the 2025 ASCO Annual Meeting

Research To Practice | Oncology Videos

Play Episode Listen Later Jul 21, 2025 60:43


Featuring perspectives from Dr Catherine C Coombs and Dr William G Wierda, including the following topics: Introduction (0:00) Selection and Sequencing of Therapy for Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia (CLL) — Dr Wierda (19:25) First-Line Therapy for CLL — Dr Coombs (44:18) Novel Agents and Strategies for R/R CLL — Dr Wierda (57:27) CME information and select publications

The Lab Report
Is Shotgun Sequencing Better Than PCR?

The Lab Report

Play Episode Listen Later Jul 16, 2025 31:54


Stool testing technology has advanced rapidly in recent years, with newer methods like PCR and whole-genome sequencing offering faster and more precise insights into the gut microbiome. These innovations have transformed how clinicians approach gut health, allowing for more targeted interventions. However, older technologies—such as microscopy, culture, and enzyme-based assays—still play a valuable role. These methods provide functional insights that molecular tools may miss, such as direct observation of parasites or assessment of digestive markers. The most comprehensive labs recognize that no single method gives the full picture. Instead, combining the strengths of both modern and traditional techniques ensures more accurate, clinically meaningful results. In this episode, we dive into the pros and cons of different laboratory methodologies used in stool testing—from culture and microscopy to PCR and advanced sequencing. We break down how these choices impact accuracy, sensitivity, and clinical usefulness. You'll also learn why Genova Diagnostics stands out for its integrative, evidence-based approach, combining multiple testing methods to deliver the most comprehensive and clinically actionable results available. Today on The Lab Report: 4:00 Technology grows quickly, and the microbiome is complex 7:30 Microbiology culture 12:40 PCR – very precise if done correctly! 17:00 Interpreting the laundry list 20:10 Remember the microscope? 23:30 Whole-genome (shotgun) sequencing pros/cons 27:15 Genova does it all – and well Additional Resources: GI Effects Stool Profile Microbiomix Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: podcast@gdx.net. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.

Vedic Worldview
Veda Vyasa: The Cosmic Storyteller

Vedic Worldview

Play Episode Listen Later Jun 30, 2025 70:55


Modern day students have a great debt of gratitude to the Vedic masters who have captured and preserved Vedic wisdom for millennia, making it available for us to apply to our lives today.One of the most prolific of these masters is Veda Vyasa, who is recognized as being responsible for documenting as much as three quarters of the Vedic literature, and organizing, or “sequencing” it, in such as way that we are still able to access and apply the wisdom even today.In this episode, which includes questions from audience members, Thom gives as a brief insight into the life and work of Veda Vyasa, the Cosmic storyteller.It's a fitting prelude to Thom's upcoming residential course, Vedanta Vyasa, to be held in Sedona this coming July. If this episode whets your appetite for more, and if you have passed the prerequisites for attending, we invite you to visit the website to find out more. Episode Highlights:[00:45] Vyasa - A Teller of Sequence[03:59] The Many Names of Vyasa[09:59] Sanskrit - Correlating Name and Form[14:25] Recognizing Patterns in the Veda[19:20] The Upavedas[23:27] Mahabharata - The Epic of Great India[25:54] The Play and Display of Elevational Theater[29:08] Breaking the Fourth Wall[32:00] Fabulous Stories Delivering Lessons to Live By[35:25] A Comprehensive Body of Work[39:43] Vedanta - The Final Conclusion[43:10] An Invitation to Explore Vyasa's Story with Thom[45:49] The Connotative - The Proper View of Ancient Texts[50:35] Q - Does Vyasa's Breaking of the Fourth Wall Have Any Implications for Free Will?[51:00] The Free Will to Determine Everything[54:46] Changing the Storyline[57:36] Q - Was Maharishi Mahesh Yogi the Vyasa of this Age?[58:04] Demonstrating Vyasa-like Sequencing of Knowledge[01:00:34] Reality is Different in Different States of Consciousness[01:04:30] Sensory Perception Brings OnenessUseful Linksinfo@thomknoles.com https://thomknoles.com/https://www.instagram.com/thethomknoleshttps://www.facebook.com/thethomknoleshttps://www.youtube.com/c/thomknoleshttps://thomknoles.com/ask-thom-anything/

Those Weekend Golf Guys
Optimal Swing Sequencing and Ball Striking Secrets

Those Weekend Golf Guys

Play Episode Listen Later Jun 29, 2025 44:53


(00:01) Powerful Golf Swing Techniques for Distance This chapter explores the importance of power in golf, emphasizing how crucial it is to utilize the ground effectively for better performance. Broadcasting from Talking Rock Ranch in Prescott, Arizona, we discuss the mechanics of power in the golf swing, explaining that it all starts from the ground up. By pushing against an immovable object like the ground, energy is generated and transferred through the body to the arms, enhancing the swing's speed and effectiveness. We highlight the common misconception that power is solely about body rotation, when in reality, timing the push against the ground is key. Through power schools and practical demonstrations, we explain how to harness this energy properly, ensuring that it is released at the right moment in the swing for maximum impact. (12:25) Swing Sequencing Tools for Golf This chapter focuses on the importance of proper sequencing in a golf swing and how it impacts energy transfer from the lower body through to the club. We explore the common issue of being out of sequence, where the arms move ahead of the torso, leading to inefficient swings. A simple solution proposed is using a rope to practice, as it naturally enforces correct sequencing since you cannot push on it. This technique helps maintain the correct order of movement: lower body, torso, arms, and then the club. Additionally, I introduce a homemade training aid using a PVC pipe inside a swim noodle to provide comfort while practicing chest rotations. This tool helps protect the arms and chest, ensuring a comfortable and effective practice session. (23:51) Improving Golf Ball Striking Technique This chapter explores the relationship between club head speed and effective ball striking in golf. While increasing club head speed is often emphasized for achieving greater distance, it is crucial to maintain contact with the center of the club face to optimize ball speed and overall performance. The importance of ball speed, spin, and launch angle in achieving longer shots is highlighted, and the potential pitfalls of focusing solely on club head speed are discussed. Additionally, the benefits of practicing with specialized equipment, such as the Tour Striker club, are examined. This unique club design encourages proper striking technique by requiring the golfer to drive the club downward and forward, thereby enhancing ball striking ability and maximizing smash factor. (27:04) Improving Distance With Proper Swing Integration This chapter explores the nuances of improving your golf game with specialized equipment and techniques. I discuss the benefits of using the Tour Striker club, which requires precise ball striking due to its design that forces players to de-loft the club for optimal launch angles and distance. Additionally, I emphasize the importance of hitting the center of the clubface to enhance distance and control, regardless of whether you're using the latest technology or a five-year-old driver. We also talk about using training aids with smaller club heads to improve accuracy and consistency. Furthermore, we cover tips on proper tee height and swing mechanics to achieve the desired launch angle and reduce spin. Finally, there's a humorous look at the use of martini tees and the common mistake of setting them too low, which can impact performance. (42:29) Putting Technique Improvement Through Visualization This chapter explores the importance of clarity and specificity in putting techniques, emphasizing the use of training tools like a putting rail to ensure the shaft and head of the putter move straight back and through. We discuss how the putter head will naturally arc, and it's crucial to focus on the straight movement of the hands and arms. I also share a personal anecdote about improving my pitching skills with Jeff's guidance, which has positively impacted my overall game. Notably, I overcame challenges with my five iron, successfully executing a beautiful 168-yard shot onto the green, highlighting the interconnectedness of honing different golf skills.

Impact Theory with Tom Bilyeu
Playing God or Saving Nature? Gene Editing, Artificial Wombs & the Return of Extinct Species | Ben Lamm PT 1

Impact Theory with Tom Bilyeu

Play Episode Listen Later May 13, 2025 61:24


In this thrilling installment of Impact Theory, Tom Bilyeu sits down with Ben Lamm, visionary founder and CEO of Colossal Biosciences, a company on a mission to reverse extinction and rewrite the future of conservation and synthetic biology. Ben and Tom dive deep into the mind-bending world of de-extinction, synthetic gene editing, and how the CRISPR revolution is not only unlocking the secrets of life—but also actively engineering it. In Part 1, get ready for a rollercoaster of concepts as Ben explains the technical magic behind gene editing, DNA synthesis, and multiplex genome editing. From the birth of the woolly mouse to the debated revival of dire wolves, Ben reveals the breakthroughs, challenges, and wild stories behind reviving extinct species. You'll learn how Colossal is using advanced computational biology, AI, and hands-on bioengineering to not only bring animals back but also reshape the future of healthcare, genetics, and ethical decision-making. This is part sci-fi, part practical science, and 100% mind-blowing. SHOWNOTES 00:00 – Kicking Off: The Mysteries of Editing Life 00:14 – Emergence of the CRISPR Revolution 01:31 – What Is DNA Synthesis and Multiplex Editing? 03:47 – The Woolly Mouse: Engineering Traits Across Species 07:54 – Breaking Down the Process: IVF, Screening, and Sequencing 09:24 – Mapping Genotype to Phenotype and Its Challenges 12:10 – Targeting Gene Edits: From Theory to Application in Health and Conservation 17:09 – From Hair Organoids to Building Mammoth Traits in Mice 24:41 – The Quest for a Universal Egg and Overcoming Cellular Barriers 26:17 – Artificial Wombs: The Next Frontier in Conservation and Science 31:12 – Scaling Conservation and Bridging to Human Healthcare FOLLOW BEN LAMM Twitter/X: @federallamm LinkedIn: Ben Lamm CHECK OUT OUR SPONSORS ButcherBox: Ready to level up your meals? Go to ⁠https://ButcherBox.com/impact⁠ to get $20 off your first box and FREE bacon for life with the Bilyeu Box! Vital Proteins: Get 20% off by going to ⁠https://www.vitalproteins.com⁠ and entering promo code IMPACT at check out Shopify: Sign up for your one-dollar-per-month trial period at ⁠https://shopify.com/impact⁠ Netsuite: Download the CFO's Guide to AI and Machine Learning at ⁠https://NetSuite.com/THEORY⁠ iTrust Capital: Use code IMPACTGO when you sign up and fund your account to get a $100 bonus at ⁠https://www.itrustcapital.com/tombilyeu⁠  Mint Mobile: If you like your money, Mint Mobile is for you. Shop plans at ⁠https://mintmobile.com/impact.⁠  DISCLAIMER: Upfront payment of $45 for 3-month 5 gigabyte plan required (equivalent to $15/mo.). New customer offer for first 3 months only, then full-price plan options available. Taxes & fees extra. See MINT MOBILE for details. What's up, everybody? It's Tom Bilyeu here: If you want my help... STARTING a business: join me here at ZERO TO FOUNDER SCALING a business: see if you qualify here. Get my battle-tested strategies and insights delivered weekly to your inbox: sign up here. ********************************************************************** If you're serious about leveling up your life, I urge you to check out my new podcast, Tom Bilyeu's Mindset Playbook —a goldmine of my most impactful episodes on mindset, business, and health. Trust me, your future self will thank you. ********************************************************************** LISTEN TO IMPACT THEORY AD FREE + BONUS EPISODES on APPLE PODCASTS: apple.co/impacttheory ********************************************************************** FOLLOW TOM: Instagram: https://www.instagram.com/tombilyeu/ Tik Tok: https://www.tiktok.com/@tombilyeu?lang=en Twitter: https://twitter.com/tombilyeu YouTube: https://www.youtube.com/@TomBilyeu Learn more about your ad choices. Visit megaphone.fm/adchoices