In genetics and biochemistry, determining the structure of an unbranched biopolymer
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Join us for an insightful episode as we dive deep into the evolving landscape of Chronic Lymphocytic Leukemia (CLL) treatment. This episode features Dr. Mazyar Shadman, an expert in lymphoid malignancies from the Fred Hutch Cancer Center. In this episode, we covered: • The importance of shared decision-making in CLL treatment. • When to initiate treatment for newly diagnosed CLL patients. • The role of time-limited venetoclax-based regimens versus continuous BTK inhibitors. • Key considerations in choosing the right BTK inhibitor and managing side effects. • The relevance of minimal residual disease (MRD) in treatment duration. • Sequencing strategies for relapsed and refractory CLL, including the use of Pirtobrutinib and CAR-T therapy. Whether you're a healthcare professional or someone interested in the latest advancements in oncology, this episode is packed with valuable insights and practical advice. Don't forget to like, subscribe, and leave us your feedback! Your support helps us bring these important discussions to a wider audience. Tune in now and stay informed about the latest in CLL treatment! Follow us on social media: • X/Twitter: https://twitter.com/oncbrothers • Instagram: https://www.instagram.com/oncbrothers • Website: https://oncbrothers.com/ #Ibrutinib #acalabrutinib #zanubrutinib #Pirtobrutinib #CLL2025 #BTKinhibitors #Venetoclax #MRDnegative #OncologyBrothers
Guest: John Cho, MD, PhD, FRCPC Surgery for mesothelioma after radiation therapy (SMART) offers new hope for patients with resectable epithelioid mesothelioma by reversing the traditional treatment sequence. Hear from Dr. John Cho as he discusses the rationale behind this decade-long clinical advancement, which he spoke about at the 2025 World Conference on Lung Cancer. Dr. Cho is a radiation oncologist at Princess Margaret Cancer Centre and an Associate Professor in the Department of Radiation Oncology at the University of Toronto.
Guest: Paola Marignani, PhD, EMBA Single-cell RNA sequencing is transforming our understanding of tumor heterogeneity in primary lung cancers by offering insights far beyond traditional bulk sequencing. In this program, Dr. Paola Marignani explores how advanced machine learning enables faster, more precise profiling of genetic diversity, predictive modeling for recurrence and drug resistance, and personalized treatment strategies. Dr. Marignani is a Professor in the Department of Biochemistry and Molecular Biology at Dalhousie University in Halifax, Novia Scotia, and she spoke about this topic at the 2025 World Conference on Lung Cancer.
Guest: John Cho, MD, PhD, FRCPC Surgery for mesothelioma after radiation therapy (SMART) offers new hope for patients with resectable epithelioid mesothelioma by reversing the traditional treatment sequence. Hear from Dr. John Cho as he discusses the rationale behind this decade-long clinical advancement, which he spoke about at the 2025 World Conference on Lung Cancer. Dr. Cho is a radiation oncologist at Princess Margaret Cancer Centre and an Associate Professor in the Department of Radiation Oncology at the University of Toronto.
Guest: Paola Marignani, PhD, EMBA Single-cell RNA sequencing is transforming our understanding of tumor heterogeneity in primary lung cancers by offering insights far beyond traditional bulk sequencing. In this program, Dr. Paola Marignani explores how advanced machine learning enables faster, more precise profiling of genetic diversity, predictive modeling for recurrence and drug resistance, and personalized treatment strategies. Dr. Marignani is a Professor in the Department of Biochemistry and Molecular Biology at Dalhousie University in Halifax, Novia Scotia, and she spoke about this topic at the 2025 World Conference on Lung Cancer.
Mark A. Stein, Ph.D., will provide an overview of pediatric ADHD treatment options, explain why it's crucial to personalize treatment, and how to combine and sequence medication and other treatments for optimal care. ADHD Treatments for Children: Additional Resources Free Download: Take Charge of Your Child's Medication Read: ADHD Treatment Options for Children Read: What Is Complex ADHD? Symptoms, Diagnosis & Treatment Read: How a Physician Treats ADHD with Combination Therapy Access the video and slides for podcast episode #571 here: https://www.additudemag.com/webinar/adhd-treatment-options-combination-therapy/ This episode is sponsored by the podcast Hyperfocus with Rae Jacobson. Search for “Hyperfocus with Rae Jacobson” in your podcast app or find links to listen at https://lnk.to/hyperfocusPS!adhdexperts. This episode is also brought to you by Brain.fm. Unlock your brain's full potential FREE for 30 days by going to brain.fm/ADDITUDE. Thank you for listening to ADDitude's ADHD Experts podcast. Please consider subscribing to the magazine (additu.de/subscribe) to support our mission of providing ADHD education and support.
Eine Landkarte, auf der nur einzelne Dörfer oder Stadtteile zu sehen sind, so wirkt klassische DNA-Analyse manchmal. Mit Long Read Sequencing verändert sich das Bild: Plötzlich werden ganze Regionen und Zusammenhänge sichtbar. In dieser Folge spricht Dr. Kornelia Neveling vom Radboud University Medical Center, Nijmegen, über die Technologie, ihre Chancen und Herausforderungen. Es geht um konkrete Fälle, spannende Hackathons und die Frage, ob Long Read Sequencing in der Zukunft der eine Test für viele genetische Diagnosen werden könnte.
Featuring an interview with Dr Erika Hamilton, including the following topics: Monitoring, mitigating and managing adverse events with antibody-drug conjugates (ADCs) for breast cancer (0:00) Heist RS et al. Clinical management, monitoring, and prophylaxis of adverse events of special interest associated with datopotamab deruxtecan. Cancer Treat Rev 2024;125:102720. Abstract Management protocols for adverse events associated with sacituzumab govitecan (7:49) García JMP et al. Prevention of sacituzumab govitecan (SG)-related neutropenia and diarrhea in patients with triple-negative or HR+/HER2- advanced breast cancer (ABC; PRIMED): A phase 2 trial. ASCO 2024;Abstract 1101. Pérez-García JM et al. Prevention of sacituzumab govitecan-related neutropenia and diarrhea in patients with HER2-negative advanced breast cancer (PRIMED): An open-label, single-arm, phase 2 trial. eClinicalMedicine 2025;85:103309. Abstract Datopotamab deruxtecan for patients with breast cancer brain metastases or leptomeningeal disease (10:51) Tarantino P et al. DATO-Base: A phase II study of DATOpotamab deruxtecan for patients with breast cancer brain metastases or leptomeningeal disease. ASCO 2025;Abstract TPS1134. Sequencing ADCs in breast cancer (13:12) Pacholczak-Madej R et al. Sequencing of antibody drug conjugates in breast cancer: Evidence gap and future directions. Biochim Biophys Acta Rev Cancer 2025;[Online ahead of print]. Abstract CME information and select publications
Starboard is building AI-first infrastructure to transform global trade by improving the productivity of freight forwarders—the central coordinators who connect 15-20 different parties in every international trade transaction. With 15 years of experience in the industry, including roles at Maersk, BCG, and Flexport, Sumeet Trehan saw an opportunity to modernize an industry that has invested heavily in physical infrastructure but neglected technological innovation. The company has raised $5.5 million and is approaching $1 million ARR while creating an entirely new category they call "AI-first forwarders." Topics Discussed: Building AI infrastructure to automate freight forwarding coordination and quoting processes Creating a new category in the traditional, relationship-driven logistics industry Go-to-market strategies for selling to an "old boys club" industry that operates differently from typical SaaS markets The founder's decision to personally handle the first 20-30 sales before hiring any sales staff Vision for transforming global trade by creating a comprehensive platform for small-to-mid-sized importers GTM Lessons For B2B Founders: Cold calling still works in traditional industries: Starboard generates significant top-of-funnel activity through direct cold calling, with freight forwarders actually appreciating the personal touch. Sumeet's team achieves a 10% pickup rate and converts 15-20% of answered calls to discovery meetings by being upfront about the cold call nature and immediately focusing on business outcomes. The approach works because their target market—freight forwarders—are accustomed to making and receiving cold calls as part of their daily business operations. Door-to-door prospecting remains viable for relationship-driven markets: In industries where personal relationships dominate, physical presence can be a differentiator. Starboard literally brings donuts to prospects' offices, which works because their target market values face-to-face interactions. This approach only makes sense when your industry culture supports it and when the lifetime value of customers justifies the time investment. Founders should personally execute early sales to understand the playbook: Rather than immediately hiring sales staff after raising funding, Sumeet chose to personally close the first 20-30 deals. This allowed him to deeply understand customer pain points, refine the sales process, and develop a replicable methodology before bringing on sales team members. Only after proving out the top-of-funnel motion did he hire his first SDR, and only after closing 15-20 deals did he hire a sales leader. Physical implementation presence drives early-stage product adoption: For complex B2B products still achieving product-market fit, being physically present during implementation creates stronger relationships and better feedback loops. Starboard's team travels to be on-site when clients first use the product, which helps with both adoption rates and product development insights. They maintain ongoing communication through WhatsApp and Teams channels rather than Slack, adapting to their customers' preferred communication methods. Category creation requires education over product promotion: Starboard's marketing strategy focuses entirely on educating the market about AI's potential impact on logistics rather than promoting their specific product. By speaking at events, writing blogs, and participating in podcasts about industry transformation rather than Starboard features, they position themselves as thought leaders. This approach builds trust and creates demand for the category before potential customers are ready to evaluate specific solutions. Sequencing product development based on customer feedback: The company's current quoting product serves as a wedge, with plans to expand into marketplace functionality and then full operations automation. Each expansion builds on customer relationships and data from the previous phase. This measured approach to product development ensures each step creates value while building toward the larger vision of comprehensive trade infrastructure. // Sponsors: Front Lines — We help B2B tech companies launch, manage, and grow podcasts that drive demand, awareness, and thought leadership. www.FrontLines.io The Global Talent Co. — We help tech startups find, vet, hire, pay, and retain amazing marketing talent that costs 50-70% less than the US & Europe. www.GlobalTalent.co // Don't Miss: New Podcast Series — How I Hire Senior GTM leaders share the tactical hiring frameworks they use to build winning revenue teams. Hosted by Andy Mowat, who scaled 4 unicorns from $10M to $100M+ ARR and launched Whispered to help executives find their next role. Subscribe here: https://open.spotify.com/show/53yCHlPfLSMFimtv0riPyM
In this juicy bonus Q&A episode, we kick things off with banter about East Coast Italian-American pride, Bradshaw's first Italian adventure, and our surprising discovery of supri- Rhode Island's beloved cured pork specialty. Then we dive into listener questions: the nitty-gritty of sequencing requirements and what to do when a distracting moaner in class sparks complaints. We explore how sequencing rules can feel limiting but also inspire creativity, and how one moaner story sends Giana spiraling into a tangent about a farter—navigating complaints, boundaries, and those unavoidable uncomfortable conversations.SEND YOUR QUESTIONS TO: CAYAYOGASCHOOL@GMAIL.COM
AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]
AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]
AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]
AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]
AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]
AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]
During the 18th International Conference on Malignant Lymphoma (ICML), June 17–21, 2025, Lugano, CH, the Lymphoma Hub held a symposium on June 17, 2025, titled Customizing therapy for mantle cell lymphoma (MCL). Here, we share a case-based presentation and panel discussion led by Wojciech Jurczak, Maria Skłodowska-Curie National Research Institute of Oncology, Kraków, PL, on sequencing therapies and practical management of adverse events in mantle cell lymphoma (MCL). This educational resource is independently supported by Eli Lilly and Company. All content was developed by SES in collaboration with an expert steering committee. Funders were allowed no influence on the content of this resource. Hosted on Acast. See acast.com/privacy for more information.
It takes intentional effort to put things into helpful sequencing. When we take time to do it, though, it can push back against anxiety in significant ways!
Sarah Elk, Senior Partner at Bain & Company and global leader of its operating model work, brings a clear, pragmatic lens to why so many large-scale change efforts fail to stick. Drawing on decades of advising multinational organizations, she diagnoses the structural and behavioral traps that cause transformations to stall, and shares the disciplines that make change durable. Elk emphasizes that transformation is not a one-off program but an enduring capability that must be “led from the top and embedded in the culture.” She cautions against outsourcing responsibility to a program office: “If the CEO is not leading it and the leadership team isn't engaged in the change, you might get something done, but it will erode quickly.” Key Insights from the Conversation: Clarity on Non-Negotiables Many failed transformations lack a shared definition of the “non-negotiables” in the new operating model. Without them, execution becomes fragmented. “You have to be crystal clear on what's standard and what's flexible.” Outcomes Over Activity Successful change efforts anchor to measurable business results, not just activity metrics or generic benchmarks. “It's not about hitting 80 percent of a checklist. It's about whether you've moved the needle on the outcomes you care about.” Leadership Alignment Is a Continuous Process Alignment isn't built in a single offsite; it requires ongoing dialogue, joint problem-solving, and confronting decisions that challenge entrenched interests. “You need the leadership team acting as one—every week, every month—not just at the kickoff.” Manage Change Fatigue Overloading the organization erodes momentum. Sequencing initiatives and celebrating visible early wins tied to strategy helps sustain energy. “People get tired. You have to show progress and give them space to breathe.” Governance, Incentives, and Talent Must Evolve Together Elk warns that without parallel changes to systems and structures, “behavior will revert to what it was before.” The discussion reframes transformation from a high-profile event into a muscle organizations must build and maintain. For executives seeking change that endures beyond the initial push, Elk offers a blueprint grounded in operational rigor, leadership accountability, and cultural realism. Get Sarah's book here: https://shorturl.at/Tyotz Doing Agile Right: Transformation Without Chaos Here are some free gifts for you: Overall Approach Used in Well-Managed Strategy Studies free download: www.firmsconsulting.com/OverallApproach McKinsey & BCG winning resume free download: www.firmsconsulting.com/resumepdf Enjoying this episode? Get access to sample advanced training episodes here: www.firmsconsulting.com/promo
Watch my first-ever conversation with a political leader on the Alloutcoach show who has also transcended business, entrepreneurship, community service, women's rights advocacy and sports science. This episode uncovers a personal story and manifestation of character and integrity of an inspiring, dynamic, and powerful leader, Hon. Leela Aheer, former Canadian Minister of Culture, Multiculturalism, and Women's rights, musician, and activist throughout her journey of transformation into becoming a business executive, entrepreneur and expert in optimizing athletic performance.In addition to lessons on sportsmanship-centered leadership in business, you will discover the difference precision medicine with multi-omics and slightest variance in our microbiome DNA can have on creating gold medalists in sports, and champions in health, training, rehabilitation and recovery.
In this juicy bonus Q&A episode, we tackle two big topics: what to do when a student asks you out (yep, it happens) and how to approach sequencing for an entire month without losing your mind. Along the way, our banter takes a few detours, including what it's like navigating an unequal partnership, the emotional weight of Bradshaw's first retreat after his dad's death, disassociating vs. Pratyahara, and other behind-the-scenes info. It's raw, real, and a little ridiculous, just how we like it.SEND YOUR QUESTIONS TO: CAYAYOGASCHOOL@GMAIL.COM
We're unpacking common myths around food sequencing, exercise, and nutrition for women, while addressing listener questions about dietary advice and fitness practices. You'll gain insights into the complexities of weight loss, the importance of cardiovascular exercise, and the real impact of food order on your health.
In this episode of The ICHE Podcast, we take a deep dive into the evolving role of plasma cell-free DNA (cfDNA) metagenomic next-generation sequencing (mNGS) in the diagnosis of infectious diseases. Hosted by experts from UCLA Health, this discussion breaks down what cfDNA mNGS is, how it differs from more traditional pathogen detection tools like PCR, and where it fits in the diagnostic landscape. Dr. Ishminder Kaur, Dr. Daniel Uslan, and Dr. Shangxin Yang join the episode to explore the clinical utility, benefits, and pitfalls of this rapidly emerging diagnostic modality. The group reviews several individual studies, highlighting how they approached their research questions, key findings, and the implications for patient care and antimicrobial stewardship. The conversation also addresses challenges such as interpreting complex results, cost considerations, and potential overuse. Whether you're a clinician, laboratorian, or infection preventionist, this episode provides critical insights into when and how cfDNA mNGS may enhance your diagnostic toolkit—and when it might not. Each guest closes with a practical takeaway: concrete advice for healthcare professionals who are considering incorporating cfDNA testing into their own clinical or infection control practice.
Sheng Zhong, Ph.D. pioneers technologies that advance women's reproductive health. Zhong develops a minimally invasive method to analyze extracellular RNA secreted by embryos during IVF. By sequencing tiny samples of spent culture media, they generate comprehensive RNA profiles and use machine learning to identify biomarkers that predict embryo quality with accuracy comparable to traditional imaging. This breakthrough offers a gentler, data-driven alternative for assessing embryo viability, with the potential to improve live birth rates and support families navigating infertility. Zhong's research highlights the power of molecular innovation to transform fertility care and address critical challenges in women's health. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40676]
Sheng Zhong, Ph.D. pioneers technologies that advance women's reproductive health. Zhong develops a minimally invasive method to analyze extracellular RNA secreted by embryos during IVF. By sequencing tiny samples of spent culture media, they generate comprehensive RNA profiles and use machine learning to identify biomarkers that predict embryo quality with accuracy comparable to traditional imaging. This breakthrough offers a gentler, data-driven alternative for assessing embryo viability, with the potential to improve live birth rates and support families navigating infertility. Zhong's research highlights the power of molecular innovation to transform fertility care and address critical challenges in women's health. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40676]
Sheng Zhong, Ph.D. pioneers technologies that advance women's reproductive health. Zhong develops a minimally invasive method to analyze extracellular RNA secreted by embryos during IVF. By sequencing tiny samples of spent culture media, they generate comprehensive RNA profiles and use machine learning to identify biomarkers that predict embryo quality with accuracy comparable to traditional imaging. This breakthrough offers a gentler, data-driven alternative for assessing embryo viability, with the potential to improve live birth rates and support families navigating infertility. Zhong's research highlights the power of molecular innovation to transform fertility care and address critical challenges in women's health. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40676]
Sheng Zhong, Ph.D. pioneers technologies that advance women's reproductive health. Zhong develops a minimally invasive method to analyze extracellular RNA secreted by embryos during IVF. By sequencing tiny samples of spent culture media, they generate comprehensive RNA profiles and use machine learning to identify biomarkers that predict embryo quality with accuracy comparable to traditional imaging. This breakthrough offers a gentler, data-driven alternative for assessing embryo viability, with the potential to improve live birth rates and support families navigating infertility. Zhong's research highlights the power of molecular innovation to transform fertility care and address critical challenges in women's health. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40676]
Sheng Zhong, Ph.D. pioneers technologies that advance women's reproductive health. Zhong develops a minimally invasive method to analyze extracellular RNA secreted by embryos during IVF. By sequencing tiny samples of spent culture media, they generate comprehensive RNA profiles and use machine learning to identify biomarkers that predict embryo quality with accuracy comparable to traditional imaging. This breakthrough offers a gentler, data-driven alternative for assessing embryo viability, with the potential to improve live birth rates and support families navigating infertility. Zhong's research highlights the power of molecular innovation to transform fertility care and address critical challenges in women's health. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40676]
Sheng Zhong, Ph.D. pioneers technologies that advance women's reproductive health. Zhong develops a minimally invasive method to analyze extracellular RNA secreted by embryos during IVF. By sequencing tiny samples of spent culture media, they generate comprehensive RNA profiles and use machine learning to identify biomarkers that predict embryo quality with accuracy comparable to traditional imaging. This breakthrough offers a gentler, data-driven alternative for assessing embryo viability, with the potential to improve live birth rates and support families navigating infertility. Zhong's research highlights the power of molecular innovation to transform fertility care and address critical challenges in women's health. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40676]
Forget 'you are what you eat.' The real game-changer? How you eat it. Science says tweaking just one thing about your meals—no willpower required—could dial up your focus, steady your mood, and keep your blood sugar in check. There is a downside though. It may make eating a little annoying. / AI pet short dramas (16:07). On the show: Steve Hatherly, Niu Honglin & Yushun
Featuring perspectives from Dr Catherine C Coombs and Dr William G Wierda, including the following topics: Introduction (0:00) Selection and Sequencing of Therapy for Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia (CLL) — Dr Wierda (19:25) First-Line Therapy for CLL — Dr Coombs (44:18) Novel Agents and Strategies for R/R CLL — Dr Wierda (57:27) CME information and select publications
In this episode, Kaila and Kyle discuss and debate the four types of jobs that they think everyone should have at least once in their career. Plus, listen ‘til the end to hear Kaila's work fail of the week. 00:00 Intro 01:06 Job #1 06:21 Pros and cons of working for a name brand 10:54 Job #2 20:04 Job #3 23:44 Job #4 29:32 Sequencing your career trajectory 32:08 Kaila's work fail of the week Want to get all of Kaila & Kyle's career resources? Subscribe to Per My Last Email: https://www.permylastemailshow.com/ Watch Per My Last Email on YouTube: @PerMYLastEmailShow Follow Per My Last Email Instagram: @permylastemailshow TikTok: @permylastemailshow Twitter: @permylast_email Have a question for us? Send us an email or voice note to permylastemail@morningbrew.com Learn more about your ad choices. Visit megaphone.fm/adchoices Each week on Per My Last Email, Morning Brew's resident career experts Kaila and Kyle – whose careers have collectively spanned the corporate, government, nonprofit and startup sectors – debate the trickiest challenges in work life, and share tactics on how to overcome them. Share the show with a friend, and leave us a review on your favorite podcast app! Learn more about your ad choices. Visit megaphone.fm/adchoices
Stool testing technology has advanced rapidly in recent years, with newer methods like PCR and whole-genome sequencing offering faster and more precise insights into the gut microbiome. These innovations have transformed how clinicians approach gut health, allowing for more targeted interventions. However, older technologies—such as microscopy, culture, and enzyme-based assays—still play a valuable role. These methods provide functional insights that molecular tools may miss, such as direct observation of parasites or assessment of digestive markers. The most comprehensive labs recognize that no single method gives the full picture. Instead, combining the strengths of both modern and traditional techniques ensures more accurate, clinically meaningful results. In this episode, we dive into the pros and cons of different laboratory methodologies used in stool testing—from culture and microscopy to PCR and advanced sequencing. We break down how these choices impact accuracy, sensitivity, and clinical usefulness. You'll also learn why Genova Diagnostics stands out for its integrative, evidence-based approach, combining multiple testing methods to deliver the most comprehensive and clinically actionable results available. Today on The Lab Report: 4:00 Technology grows quickly, and the microbiome is complex 7:30 Microbiology culture 12:40 PCR – very precise if done correctly! 17:00 Interpreting the laundry list 20:10 Remember the microscope? 23:30 Whole-genome (shotgun) sequencing pros/cons 27:15 Genova does it all – and well Additional Resources: GI Effects Stool Profile Microbiomix Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: podcast@gdx.net. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.
Send us a textDo you ever find yourself happy with the lessons you are creating, only to have students forget everything a month later? Perhaps we need to slow down more? Or spiral? It's the constant question in our teacher minds: How do we help students really learn this stuff? As our guest today will argue: We Need to Be Mindful in the Way We Sequence Learning Math!Follow Dan on BlueSky: @danielk.bsky.socialOr on Twitter: @KauDan721You can see Dan's website at: scmath.orgListened to the episode? Now, it's your turn to share! Go to our BlueSky: @DebateMath to share your thoughts. Don't forget to check out the video version of this podcast on our YouTube channel!Keep up with all the latest info by following @DebateMath or going to debatemath.com. Follow us @Rob_Baier & @cluzniak. And don't forget to rate and review us on Apple Podcasts!
Featuring perspectives from Dr Matthew D Galsky, Prof Andrea Necchi and Prof Thomas Powles, moderated by Dr Galsky, including the following topics: Introduction (0:00) Current and Future Management of Muscle-Invasive Bladder Cancer — Prof Powles (1:14) Novel Intravesical Therapies Under Evaluation for Nonmetastatic Urothelial Bladder Cancer (UBC) — Prof Necchi (24:48) Selection and Sequencing of Therapy for Metastatic UBC — Dr Galsky (44:52) CME information and select publications
Featuring perspectives from Dr Jeremy S Abramson, Dr Joshua Brody, Dr Christopher Flowers, Dr Ann LaCasce and Dr Tycel Phillips, moderated by Dr Abramson, including the following topics: Introduction (0:00) Selection and Sequencing of Available Therapies for Diffuse Large B-Cell Lymphoma — Dr Flowers (2:24) Evolving Management Paradigm for Mantle Cell Lymphoma — Dr Phillips (31:53) Integration of Novel Therapies into the Management of Follicular Lymphoma — Dr LaCasce (54:51) Integrating Bispecific Antibodies into the Management of Non-Hodgkin Lymphoma (NHL) — Dr Brody (1:11:22) Current Role of CAR T-Cell Therapy in Various NHL Subtypes — Dr Abramson (1:37:55) CME information and select publications
Featuring perspectives from Dr Harold J Burstein, Dr Javier Cortés, Prof Rebecca A Dent, Dr Kevin Kalinsky, Dr Hope S Rugo and Dr Joyce O'Shaughnessy, moderated by Dr Rugo, including the following topics: Introduction (0:00) Optimizing the Management of HER2-Positive Metastatic Breast Cancer (mBC) — Dr Cortés (3:52) Individualized Selection of Up-Front Therapy for Patients with HR-Positive, HER2-Negative mBC — Dr Kalinsky (23:10) Available Therapies for Patients with HR-Positive, HER2-Negative Disease Progressing on CDK4/6 Inhibition — Dr Burstein (48:09) Current and Potential Future Role of HER2-Targeted Therapy for HER2-Low and HER2-Ultralow Disease — Dr O'Shaughnessy (1:04:00) Current and Future Strategies for Patients with Endocrine-Refractory HR-Positive mBC — Dr Rugo (1:22:28) Selection and Sequencing of Therapy for Patients with Metastatic Triple-Negative Breast Cancer — Prof Dent (1:42:51) CME information and select publications
Send us a textThe conventional approach to withdrawing retirement funds generally involves withdrawing from taxable accounts first, followed by tax-deferred accounts, and finally tax-free accounts. This strategy can minimize taxes and maximize the growth of tax-advantaged investments. Does that mean that this is the best approach for everyone? Like most retirement-related topics, the answer is not a simple yes or no. If you'd like to be a part of a free online retirement community, join us on Facebook: https://www.facebook.com/groups/399117455706255/?ref=share
Modern day students have a great debt of gratitude to the Vedic masters who have captured and preserved Vedic wisdom for millennia, making it available for us to apply to our lives today.One of the most prolific of these masters is Veda Vyasa, who is recognized as being responsible for documenting as much as three quarters of the Vedic literature, and organizing, or “sequencing” it, in such as way that we are still able to access and apply the wisdom even today.In this episode, which includes questions from audience members, Thom gives as a brief insight into the life and work of Veda Vyasa, the Cosmic storyteller.It's a fitting prelude to Thom's upcoming residential course, Vedanta Vyasa, to be held in Sedona this coming July. If this episode whets your appetite for more, and if you have passed the prerequisites for attending, we invite you to visit the website to find out more. Episode Highlights:[00:45] Vyasa - A Teller of Sequence[03:59] The Many Names of Vyasa[09:59] Sanskrit - Correlating Name and Form[14:25] Recognizing Patterns in the Veda[19:20] The Upavedas[23:27] Mahabharata - The Epic of Great India[25:54] The Play and Display of Elevational Theater[29:08] Breaking the Fourth Wall[32:00] Fabulous Stories Delivering Lessons to Live By[35:25] A Comprehensive Body of Work[39:43] Vedanta - The Final Conclusion[43:10] An Invitation to Explore Vyasa's Story with Thom[45:49] The Connotative - The Proper View of Ancient Texts[50:35] Q - Does Vyasa's Breaking of the Fourth Wall Have Any Implications for Free Will?[51:00] The Free Will to Determine Everything[54:46] Changing the Storyline[57:36] Q - Was Maharishi Mahesh Yogi the Vyasa of this Age?[58:04] Demonstrating Vyasa-like Sequencing of Knowledge[01:00:34] Reality is Different in Different States of Consciousness[01:04:30] Sensory Perception Brings OnenessUseful Linksinfo@thomknoles.com https://thomknoles.com/https://www.instagram.com/thethomknoleshttps://www.facebook.com/thethomknoleshttps://www.youtube.com/c/thomknoleshttps://thomknoles.com/ask-thom-anything/
(00:01) Powerful Golf Swing Techniques for Distance This chapter explores the importance of power in golf, emphasizing how crucial it is to utilize the ground effectively for better performance. Broadcasting from Talking Rock Ranch in Prescott, Arizona, we discuss the mechanics of power in the golf swing, explaining that it all starts from the ground up. By pushing against an immovable object like the ground, energy is generated and transferred through the body to the arms, enhancing the swing's speed and effectiveness. We highlight the common misconception that power is solely about body rotation, when in reality, timing the push against the ground is key. Through power schools and practical demonstrations, we explain how to harness this energy properly, ensuring that it is released at the right moment in the swing for maximum impact. (12:25) Swing Sequencing Tools for Golf This chapter focuses on the importance of proper sequencing in a golf swing and how it impacts energy transfer from the lower body through to the club. We explore the common issue of being out of sequence, where the arms move ahead of the torso, leading to inefficient swings. A simple solution proposed is using a rope to practice, as it naturally enforces correct sequencing since you cannot push on it. This technique helps maintain the correct order of movement: lower body, torso, arms, and then the club. Additionally, I introduce a homemade training aid using a PVC pipe inside a swim noodle to provide comfort while practicing chest rotations. This tool helps protect the arms and chest, ensuring a comfortable and effective practice session. (23:51) Improving Golf Ball Striking Technique This chapter explores the relationship between club head speed and effective ball striking in golf. While increasing club head speed is often emphasized for achieving greater distance, it is crucial to maintain contact with the center of the club face to optimize ball speed and overall performance. The importance of ball speed, spin, and launch angle in achieving longer shots is highlighted, and the potential pitfalls of focusing solely on club head speed are discussed. Additionally, the benefits of practicing with specialized equipment, such as the Tour Striker club, are examined. This unique club design encourages proper striking technique by requiring the golfer to drive the club downward and forward, thereby enhancing ball striking ability and maximizing smash factor. (27:04) Improving Distance With Proper Swing Integration This chapter explores the nuances of improving your golf game with specialized equipment and techniques. I discuss the benefits of using the Tour Striker club, which requires precise ball striking due to its design that forces players to de-loft the club for optimal launch angles and distance. Additionally, I emphasize the importance of hitting the center of the clubface to enhance distance and control, regardless of whether you're using the latest technology or a five-year-old driver. We also talk about using training aids with smaller club heads to improve accuracy and consistency. Furthermore, we cover tips on proper tee height and swing mechanics to achieve the desired launch angle and reduce spin. Finally, there's a humorous look at the use of martini tees and the common mistake of setting them too low, which can impact performance. (42:29) Putting Technique Improvement Through Visualization This chapter explores the importance of clarity and specificity in putting techniques, emphasizing the use of training tools like a putting rail to ensure the shaft and head of the putter move straight back and through. We discuss how the putter head will naturally arc, and it's crucial to focus on the straight movement of the hands and arms. I also share a personal anecdote about improving my pitching skills with Jeff's guidance, which has positively impacted my overall game. Notably, I overcame challenges with my five iron, successfully executing a beautiful 168-yard shot onto the green, highlighting the interconnectedness of honing different golf skills.
In 2020, A. Wes Mitchell wrote a document to be considered by the Office of Net Assessment of the Department of Defense entitled “Strategic Sequencing: How Great Powers Avoid Multi-Front Wars”. We discuss this document and consider the question does this article provide a possible framework for the US Ruling class maintaining empire or THE framework for how it has approached this question? Check us out!https://youtu.be/nItmqkrpWHU To see all our episodes go to:What's Left? Website: https://whatsleftpodcast.com/iTunes: Spotify: Bitchute: YouTube: LBRY: Telegram :Odysee: Googleplaymusic: Rumble
Sequencing with purpose transforms the yoga practice and our teaching. Today we're going deep on gait, a pillar of my Flow School method, and its application in creating more intuitive, sustainable sequences.Learn more about Flow School hereWeekly stories by email from Bonnie's HERE Connect with Bonnie: Instagram, Email (hello@bonnieweeks.com), WebsiteListen to Bonnie's other podcast Sexy Sunday HERE The music for this episode is Threads by The Light Meeting. Produced by: Grey Tanner
What if chasing wealth was actually costing you your health—and slowing your business growth? In today's episode of The Mind of George Show, George reconnects with Mauro Stara, CEO of Six Pack CEO, to reveal the critical connection between peak performance, biological health, and entrepreneurial success. Mauro shares why entrepreneurs can't afford to delay their health journey, how to optimize core pillars like sleep and recovery, and why mastering your biology is your ultimate business advantage. If you're ready to stop grinding and start thriving, this episode is your blueprint.What You'll Learn in This EpisodeHow delaying your health journey is costing you business growthThe four foundational pillars for achieving peak performanceWhy mastering your recovery is more powerful than working harderHow your biology is either your biggest asset—or your biggest liabilitySimple, actionable shifts to optimize your energy, focus, and health starting todayKey Takeaways✔️Prioritize Health Early: Waiting for financial success before focusing on health actually slow down business success.✔️The Four Pillars: Recovery (sleep and stress management), nutrition, resistance training, and daily activity are the foundation of sustainable high performance.✔️Optimize Recovery, Not Just Effort: You don't need to work less—you need to recover better.✔️Focus on Simplicity, Not Biohacks: Master the basics like consistent sleep, sunlight exposure, movement, and nutrition before diving into complex optimization tools.✔️Track with Data: Blood work is critical to tailoring your optimization journey—don't just copy influencers or random online advice. Timestamps[00:00] The trap of “I'll prioritize my health when I hit my goals”[02:00] Why biology dictates business success[04:00] Meet Mauro Stara and the Six Pack CEO philosophy[06:00] Sequencing priorities: how health impacts wealth[10:00] Investing in your biology for accelerated growth[18:00] The Four Pillars of Peak Performance[22:00] Burnout: under-recovery vs. overwork[28:00] How deep sleep and REM impact your hormones and recovery[33:00] How eating timing affects blood sugar and sleep quality[38:00] Why simple habits beat fancy biohacks every time[45:00] Common mistakes in chasing peak performance[52:00] How to use blood work to guide your optimization[57:00] The mindset shift: there is no “finish line” for your health Choose Your Next Steps:Audit your core pillars: sleep, nutrition, training, and activity. Pick ONE area where you can make a simple improvement this week—and commit to it for the next 7 days.Bonus: DM George or Mauro and share what pillar you're committing to upgrade!Connect with Mauro Stara:Instagram: @maurostaraofficialWebsite: sixpackceo.comJoin The Alliance – The Relationship Beats Algorithms™ community for entrepreneurs who scale with trust and connectionApply for 1:1 Coaching – Ready to build your business with sustainability, impact, and ease? Apply hereLive Events – Get in the room where long-term success is built: mindofgeorge.com/event
Featuring perspectives from Dr Farshid Dayyani, Ms Caroline Kuhlman, Dr Philip A Philip and Ms Amanda K Wagner, including the following topics: Introduction: Initial Management of Pancreatic Adenocarcinoma (PAD) (0:00) Clinical Presentation and Prognosis of PAD; Recent Advances in Up-Front Treatment for Metastatic PAD (19:01) Selection and Sequencing of Therapy for Relapsed/Refractory Metastatic PAD (54:38) Importance of Palliative Care for Advanced PAD (1:06:09) Role of PARP Inhibitor Maintenance Therapy for Newly Diagnosed Metastatic PAD (1:14:59) Promising Investigational Strategies for PAD (1:26:56) NCPD information and select publications
Episode 386 Show Notes Topic of the show: VFR Vectors to Final. Sponsored by SGAC Patron SA On this week's show, RH and AG discuss sequencing VFR's to a Charlie airport and the etiquette involved on both sides of the mic. We also discuss a real life center controller sighting, confusing late night flying mistakes, and more of your awesome aviation feedback. Links: https://youtu.be/Dml3O6Irmt0 Timely Feedback: 1. Army IP DS answers the radar altimeter question from last week, thanks! 2. Patron SRD answers the radar altimeter question also, thank you! 3. Patron BDM asks about controllers after an incident 4. Patron JAC sends a story about his first solo cross country Feedback 1. Patron TS discusses shift work as a submariner 2. Harrier the Bean sends several interactions with ATC 3. Patron SG sends audio about audio 4. Patron DDC talks night flying for IFR training 5. Patron DB talks about a recent Center tour Have a great week and thanks for listening! Visit our website at OpposingBases.com You can support our show using Patreon or visiting our support page on the website. Keep the feedback coming, it drives the show! Don't be shy, use the “Send Audio to AG and RH” button on the website and record an audio message. Or you can send us comments or questions to feedback@opposingbases.com. Music bumpers by audionautix.com. Third party audio provided by liveatc.net. Legal Notice The views and opinions expressed on Opposing Bases Air Traffic Talk are for entertainment purposes only and do not represent the views, opinions, or official positions of the FAA, Penguin Airlines, or the United States Army. Episodes shall not be recorded or transcribed without express written consent. For official guidance on laws, rules, and regulations, consult an aviation attorney or certified flight instructor.
In this episode of The Perceptive Photographer, I dive into the relationship between form and content in photography, especially when editing and sequencing a body of work. While a photo might carry personal meaning for me, I know it doesn't inherently hold that story for the viewer—it's their interpretation that brings it to life. That's why I encourage photographers to critically assess what's included and excluded in the frame to better communicate their intent.
In this thrilling installment of Impact Theory, Tom Bilyeu sits down with Ben Lamm, visionary founder and CEO of Colossal Biosciences, a company on a mission to reverse extinction and rewrite the future of conservation and synthetic biology. Ben and Tom dive deep into the mind-bending world of de-extinction, synthetic gene editing, and how the CRISPR revolution is not only unlocking the secrets of life—but also actively engineering it. In Part 1, get ready for a rollercoaster of concepts as Ben explains the technical magic behind gene editing, DNA synthesis, and multiplex genome editing. From the birth of the woolly mouse to the debated revival of dire wolves, Ben reveals the breakthroughs, challenges, and wild stories behind reviving extinct species. You'll learn how Colossal is using advanced computational biology, AI, and hands-on bioengineering to not only bring animals back but also reshape the future of healthcare, genetics, and ethical decision-making. This is part sci-fi, part practical science, and 100% mind-blowing. SHOWNOTES 00:00 – Kicking Off: The Mysteries of Editing Life 00:14 – Emergence of the CRISPR Revolution 01:31 – What Is DNA Synthesis and Multiplex Editing? 03:47 – The Woolly Mouse: Engineering Traits Across Species 07:54 – Breaking Down the Process: IVF, Screening, and Sequencing 09:24 – Mapping Genotype to Phenotype and Its Challenges 12:10 – Targeting Gene Edits: From Theory to Application in Health and Conservation 17:09 – From Hair Organoids to Building Mammoth Traits in Mice 24:41 – The Quest for a Universal Egg and Overcoming Cellular Barriers 26:17 – Artificial Wombs: The Next Frontier in Conservation and Science 31:12 – Scaling Conservation and Bridging to Human Healthcare FOLLOW BEN LAMM Twitter/X: @federallamm LinkedIn: Ben Lamm CHECK OUT OUR SPONSORS ButcherBox: Ready to level up your meals? Go to https://ButcherBox.com/impact to get $20 off your first box and FREE bacon for life with the Bilyeu Box! Vital Proteins: Get 20% off by going to https://www.vitalproteins.com and entering promo code IMPACT at check out Shopify: Sign up for your one-dollar-per-month trial period at https://shopify.com/impact Netsuite: Download the CFO's Guide to AI and Machine Learning at https://NetSuite.com/THEORY iTrust Capital: Use code IMPACTGO when you sign up and fund your account to get a $100 bonus at https://www.itrustcapital.com/tombilyeu Mint Mobile: If you like your money, Mint Mobile is for you. Shop plans at https://mintmobile.com/impact. DISCLAIMER: Upfront payment of $45 for 3-month 5 gigabyte plan required (equivalent to $15/mo.). New customer offer for first 3 months only, then full-price plan options available. Taxes & fees extra. See MINT MOBILE for details. What's up, everybody? It's Tom Bilyeu here: If you want my help... STARTING a business: join me here at ZERO TO FOUNDER SCALING a business: see if you qualify here. Get my battle-tested strategies and insights delivered weekly to your inbox: sign up here. ********************************************************************** If you're serious about leveling up your life, I urge you to check out my new podcast, Tom Bilyeu's Mindset Playbook —a goldmine of my most impactful episodes on mindset, business, and health. Trust me, your future self will thank you. ********************************************************************** LISTEN TO IMPACT THEORY AD FREE + BONUS EPISODES on APPLE PODCASTS: apple.co/impacttheory ********************************************************************** FOLLOW TOM: Instagram: https://www.instagram.com/tombilyeu/ Tik Tok: https://www.tiktok.com/@tombilyeu?lang=en Twitter: https://twitter.com/tombilyeu YouTube: https://www.youtube.com/@TomBilyeu Learn more about your ad choices. Visit megaphone.fm/adchoices
Feeling overwhelmed by a never-ending task list? The most successful people don't do everything, they do the right things in the right order. This clip breaks down why mastering sequencing is the secret to growing in life and business without burning out. Learn to prioritize what truly matters, and build a schedule that honors both your hustle and your health. Longevity wins.Get access to our real estate community, coaching, courses, and events at Wealthy University https://www.wealthyuniversity.com/Join our FREE community, weekly calls, and bible studies for Christian entrepreneurs and business people. https://www.wealthykingdom.com/ If you want to level up, text me at 725-527-7783!--- About Ryan Pineda: Ryan Pineda has been in the real estate industry since 2010 and has invested in over $100,000,000 of real estate. He has completed over 700 flips and wholesales, and he owns over 650 rental units. As an entrepreneur, he has founded seven different businesses that have generated 7-8 figures of revenue. Ryan has amassed over 2 million followers on social media and has generat...
TikTok Flat Earthers; News Items: De-extincting the Dire Wolf, What Experts Think About AI, Planned Obsolescence, VR Touch Sensory; Who's That Noisy; Your Questions and E-mails: SNPs vs Sequencing; Science or Fiction
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