Podcasts about Sequencing

What matters most to patients with non-muscle invasive bladder cancer (NMIBC)? In this episode of BackTable Urology, Dr. Kelly Bree, Dr. Saum Ghodoussipour, and Meredith Donahue, N.P., join host Dr. Vignesh Packiam to discuss the power of shared decision-making across the NMIBC spectrum. They explore risk-adapted treatment selection, when to escalate or de-escalate therapy, and how to navigate conversations about recurrence risk, treatment burden, quality of life, and the possibility of cystectomy. --- Get the BackTable apphttps://www.backtable.com/app --- This podcast is supported by an educational grant from Johnson & Johnson. --- Timestamps 00:00 - Introduction01:55 - Second Opinions and Patient Counseling06:08 - Intermediate Risk Stratification12:13 - Treatment Options for Intermediate Risk NMIBC16:20 - BCG and Alternative Treatments for High Risk NMIBC26:49 - Options for BCG-Unresponsive NMIBC31:42 - Sequencing and Cystectomy37:03 - Financial and Time Toxicity41:08 - Biomarkers and ctDNA44:04 - Future Trials and NMIBC Innovations --- More about this episode They also review emerging therapies such as ZUSDURI, the evolving role of intravesical treatments, and the promise of biomarkers and ctDNA for personalized care. The discussion covers practical strategies for patient counseling, key updates to clinical guidelines, and a preview of innovations shaping the future of NMIBC management. --- Resources Active Surveillance Versus Intravesical Bacillus Calmette-Guérin for High-grade T1 Bladder Cancer with Negative Second Transurethral Resection: The Randomized Noninferiority Phase 3 JCOG1019 Trial:https://pubmed.ncbi.nlm.nih.gov/41571573/ Twelve-Month Results From the CISTO Study Comparing Radical Cystectomy Versus Bladder-Sparing Therapy for Recurrent High-Grade Non–Muscle-Invasive Bladder Cancerhttps://ascopubs.org/doi/10.1200/JCO-25-01324 CIRCULATING TUMOR DNA AS A BIOMARKER FOR UPSTAGING AND ADVERSE PATHOLOGY IN HIGH-RISK NON–MUSCLE-INVASIVE BLADDER CANCER:https://www.auajournals.org/doi/abs/10.1097/01.JU.0001191388.74345.c9.09 Preoperative Circulating Tumor DNA Predicts Upstaging and Recurrence in High-Risk Nonmuscle-Invasive Bladder Cancer Undergoing Radical Cystectomyhttps://pubmed.ncbi.nlm.nih.gov/41843048/ --- BackTable Urology is the go-to podcast for urologists, urologic oncologists, and urogynecologists. Download the free BackTable app to get early access to new episodes, cases, and courses curated by physicians in your specialty. ► https://www.backtable.com/app

Ten University of Idaho graduate students who participated in a recent tour of the state's potato industry witnessed the full supply chain.

Fundraising is relationship building, but too many donor conversations feel disconnected, repetitive, and transactional. Enter the “Donor Waltz”. A three-step sequence of conversations designed to move donors from discovery to alignment, to meaningful commitment. Donors experience philanthropy emotionally, not operationally, and organizations that fail to find the emotional journey risk losing momentum, trust, and transformational opportunities. When fundraisers learn to sequence conversations, donor relationships begin to feel less like a checklist and more like a partnership.

Send us a message.We open with Daniel Arnold's new book You Are What You Do from Loose Joints — the sequencing, the blank pages, the editor's role — and end up on a harder question: what happens when you spend a decade on something and the first question someone asks is "what's next?" We talk through Josh Safdie's account of finishing Uncut Gems and why that question lands like an insult, and whether there's also something honest, even useful, about just moving on.That leads into the photo walk question: can you actually make work when you're with other people, or is this a medium that demands solitude? We use it as a way into what we think is genuinely missing from the Omaha creative scene — not talent, but the kind of competitive pressure that only comes from being around people operating at a high level and taking it seriously. We draw a line between community (people talking about ideas) and scene (people making work and raising the floor for each other).We also get into the difference between finding something valuable and making something from nothing, what it actually takes to own the label of photographer or writer without feeling like you're lying, and why "what's the point?" is the specific thought pattern that keeps you consuming instead of working. The answer, more or less: momentum is the point. -AiSupport the show If you enjoyed this episode, please consider giving us a rating and/or a review. We appreciate and try to read all of them. Thanks for listening, and we'll see you in the next episode. Links To Everything: Video Version of The Podcast: https://geni.us/StudioSessionsYT Matt's YouTube Channel: https://geni.us/MatthewOBrienYT Matt's 2nd Channel: https://geni.us/PhotoVideosYT Alex's YouTube Channel: https://geni.us/AlexCarterYT Matt's Instagram: https://geni.us/MatthewIG Alex's Instagram: https://geni.us/AlexIG 

There is a crucial difference between timelines and sequences, and if you want jurors to see your case as plainly as you see it, you need to pay close attention. Today we explore not just how timelines help jurors understand the case quickly, but why that is: the psychology and brain science behind retaining information. Timelines are a curated visual picture of the case, sequencing is about the order of presenting evidence. Similar, yet each with their own distinct psychologies. I know, not all lawyers use timelines, but they can be very effective, and focus groups help you recognize and fine tune what is most likely to register with juries. We want to make things as clear as possible for the jury, so don't lose your jury because you're jumping around the timeline. Logic, clarity and chronology that are structured and presented well can make all the difference. If you want to test your timeline and sequencing presentation on a focus group, book a free call with me and let's get set up:   https://www.calendly.com/elizabethlarrick   In this episode, we cover: How cognitive science shows that the first information is often assumed to be the first event. Why sequencing is essential for guiding jurors to a conclusion. How focus groups can help identify key events for timelines. Why overloading jurors with information can lead to confusion and undermine your case. Both timelines and sequencing are necessary for effective persuasion. Further links and references from this episode: Episode 158: Trial Strategy v. Trial Tactics New Blog post: Which Virtual Focus Group does Your Case Need? You can also watch today's episode on my YouTube Channel: Trial Strategy in Action: Timelines, Sequencing, and What Wins [Ep 167]   Follow and Review: We'd love for you to follow us if you haven't yet. Click that purple '+' in the top right corner of your Apple Podcasts app. We'd love it even more if you could drop a review or 5-star rating over on Apple Podcasts. Simply select "Ratings and Reviews" and "Write a Review" then a quick line with your favorite part of the episode. It only takes a second and it helps spread the word about the podcast. Don't miss out on the Trial Lawyer Prep Newsletter that is delivered right to your email with extra tips and 'how to' information. Join the newsletter here: www.larricklawfirm.com/connect

Trump's Raúl Castro move and what it signals for Cuba. Patrick Bet-David and the panel explain why the 1996 Brothers to the Rescue shootdown indictment matters now, call out Obama's friendly Cuba photo ops, and debate whether Trump is quietly setting up post-Castro regime change.

Today, we are breaking down Auto1, and this is an interesting episode because we are tackling a business that most US listeners will not be familiar with, even though it resembles names they already know well. Our guest is Harrison Moot, co-founder and CIO of Sandstone, who walks us through Europe's largest vertically integrated online marketplace for used cars. Auto1 is often shorthanded as the Carvana of Europe, and the comparison directionally fits, but the differences are what make the company worth understanding on its own terms. The core of the conversation is how Harrison frames the company. He argues that Auto1 is best understood as a pan-European clearing house for used vehicles rather than a dealer with a website, and that the model only works because the company built its consumer sourcing engine and its wholesale dealer liquidity for nearly a decade before ever launching the consumer retail business. Owning the sourcing, logistics, refurbishment, and financing stack across thirty fragmented national markets gives Auto1 a pricing and routing advantage that local dealers and asset-light classifieds cannot replicate. Please enjoy this Breakdown of Auto1. For the full show notes, transcript, and links to the best content to learn more, check out the episode page⁠⁠⁠⁠⁠⁠⁠ here.⁠⁠⁠⁠⁠⁠⁠ ----- Become a Colossus member to get our quarterly print magazine and private audio experience, including exclusive profiles and early access to select episodes. Subscribe at ⁠colossus.com/subscribe⁠. ----- This episode is brought to you by⁠⁠⁠⁠ ⁠Portrait Analytics⁠⁠⁠⁠⁠ - your centralized resource for AI-powered idea generation, thesis monitoring, and personalized report building. Built by buy-side investors, for investment professionals. We work in the background, helping surface stock ideas and thesis signposts to help you monetize every insight. In short, we help you understand the story behind the stock chart, and get to "go, or no-go" 10x faster than before. Sign-up for a free trial today at ⁠⁠⁠⁠⁠portraitresearch.com⁠⁠⁠⁠⁠ ----- Stay up to date on all our podcasts by signing up to Colossus Weekly, our quick dive every Sunday highlighting the top business and investing concepts from our podcasts and the best of what we read that week. Sign up here. ----- Editing and post-production work for this episode was provided by The Podcast Consultant (⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://thepodcastconsultant.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠). Timestamps (00:00:00) Welcome to Business Breakdowns (00:03:35) Auto1 Business Overview  (00:07:06) European Market & C2B Model  (00:12:31) Founding Story & Sequencing  (00:16:39) Why Cazoo Failed  (00:16:42) Cazoo vs. Auto1 Approach  (00:18:29) How a Transaction Works  (00:22:11) Dealer Buying Patterns  (00:25:49) Retail vs. Wholesale  (00:26:18) Consumer Financing & ABS  (00:27:57) ABS Lowers Funding Costs  (00:28:16) Unit Economics by Segment  (00:32:37) Network Effects & Data Moat  (00:37:35) Path to Margin Expansion  (00:42:23) Balance Sheet & Working Capital  (00:44:40) Four Growth Levers  (00:48:27) Dealers: Customers Not Competitors  (00:53:17) Four Key Business Risks  (00:54:12) Inventory Risk & Mitigants  (00:58:32) Valuation Framework & Multiples  (01:03:14) Vertical Integration & Capital Cycles

With over 30 years in high performance sport, Ben Sporer has seen what it takes to be successful at the highest level of sport. From Canadian Olympic athletes to the Vancouver Whitecaps of the MLS, Ben has made a career on being clear and intentional about the goals of his program. So where do we […] The post Ben Sporer on Sequencing Training, Clear Objectives and Marginal Gains appeared first on Robertson Training Systems.

HIV research is one of the clearest examples of molecular biology in action. In this Mol Bio Minutes episode, Dr. Ryan Jeep walks through how fundamental molecular techniques power everything from detection to drug resistance studies to cure-focused research. Ryan begins with HIV biology and detection, explaining how qRT-PCR enables highly sensitive viral load measurement. These assays not only detection strategies but also support research to monitor treatment efficacy and viral rebound. From there, he moves into drug resistance, describing how sequencing, RT-PCR, and cloning strategies help researchers map resistance-associated mutations. By generating recombinant reporter viruses and measuring infectivity against different drugs, scientists can better understand treatment failure and move toward more personalized therapeutic strategies. Finally, Ryan explores cutting-edge cure research, including CRISPR-Cas9 approaches aimed at either disabling integrated viral genomes or engineering HIV-resistant immune cells. Across all three areas one theme remains constant: PCR, sequencing, and cloning form the technological backbone of HIV research. As these tools continue to evolve, so too does the potential to improve outcomes and one day eliminate the virus entirely. Since recording this episode, Ryan has joined KBI Biopharma as a Scientist l in their Formulation Development Group. Helpful resources and links: Access Stanford University's HIV Drug Resistance Database. Visit International AIDS Society's Towards an HIV Cure site, which includes resources.  Access Thermo Fisher PCR resources and products. Learn about RT-qPCR, which is relevant to HIV research.  Explore the cloning technologies referenced in this episode.  Subscribe to get future episodes as they drop and if you like what you're hearing we hope you'll share a review or recommend the series to a colleague.  Visit the Invitrogen School of Molecular Biology to access helpful molecular biology resources and educational content, and please share this resource with anyone you know working in molecular biology. For Research Use Only. Not for use in diagnostic procedures.

David Bell, co-founder of Idea Farm Ventures and early investor behind Warby Parker, Harry's, and Diapers.com, and CJ break down how consumer investing works. They cover why durable consumer companies require more than clean unit economics, how to apply SaaS-style thinking to businesses without contracts, and why the best opportunities often live in boring gray space.—SPONSORS:EY works with high-growth tech companies to navigate the messy realities of scaling—from regulatory requirements to IPO readiness. By helping teams get it right early and often, EY lets founders stay focused on building while reducing risk as they grow. Learn more at https://www.ey.com/techstartupsSpendHound is a SaaS spend management platform built for finance and procurement teams that want visibility and leverage in every deal. By tracking all your software, benchmarking pricing across thousands of vendors, and surfacing contracts and renewals, SpendHound helps you stop overpaying and negotiate with confidence. Trusted by teams at ZoomInfo and Hootsuite. Get started at https://www.spendhound.com/cjBrex is an intelligent finance platform that combines corporate cards, built-in expense management, and AI agents to eliminate manual finance work. By automating expense reviews and reconciliations, Brex gives CFOs more time for the high-impact work that drives growth. Join 35,000+ companies like Anthropic, Coinbase, and DoorDash at https://www.brex.com/metricsAleph is a modern FP&A platform built for teams that want more than another planning tool. By connecting your ERP, CRM, and other systems into one trusted data layer with AI workflows, Aleph helps you move faster with real-time insights. Get a personalized demo at https://www.getaleph.com/runRightRev is an automated revenue recognition platform built for teams that have outgrown spreadsheets and billing tool workarounds. It handles high-volume subscriptions, usage-based contracts, and mid-cycle upgrades, so you can scale without scrambling at month-end. For RevRec that keeps your books clean, visit https://www.rightrev.com/CJRillet is an AI-native ERP built for modern finance teams that want to replace NetSuite and close faster. With revenue recognition, close management, multi-entity support, and native Stripe and Salesforce integrations, Rillet helps scaling companies run their finance stack in one place. Hundreds of teams, including Windsurf and Mercor, use Rillet to make the zero-day close real. Book a demo at https://www.rillet.com/cj—Mostly Talent: https://mostlymetrics.typeform.com/to/cLTxtAsNGuest: https://www.linkedin.com/in/david-bell-086820/Company: https://www.ideafarmventures.com/CJ: https://www.linkedin.com/in/cj-gustafson-13140948/Mostly metrics: https://www.mostlymetrics.com—TIMESTAMPS:0:00 Preview and intro3:16 Edge: economics and psychology5:21 Best ideas in boring gray space5:41 Functional, emotional, and symbolic value7:08 Grüns gummies and divisibility9:02 Sponsors — EY | SpendHound | Brex12:31 Ideation: personal pain vs. market analysis13:17 Diapers.com and the Starbucks origin story16:00 Warby Parker: asking why16:33 LTV to CAC in D2C18:02 Retention math: 85 to 90% can double LTV19:00 Milkman and recurring vs. reoccurring20:42 Trust economics22:38 Warby stores boost online sales22:58 Sponsors — Aleph | RightRev | Rillet26:12 Away store as advertising27:46 Warby discovery: dots on a map30:10 Home try-on word of mouth value32:09 D2C unit economics mistakes34:55 Innovating on distribution35:50 Touchland in Sephora: right channel, right signal37:00 Capital allocation: margin and low CAC first39:18 Sequencing: people, brand, then inventory40:58 Product vs. brand: the 8x10 thought experiment42:23 Consumer monetization shifts45:45 The gravity framework50:32 Isolation principle: most underused lever52:36 Working backwards from exit at day zero57:23 What if your business isn't venture scale?59:32 Book plug: Founders Gold1:00:25 Credits

Mehr Informationen zu uns und unserer Fitness Body Challenge findest du hier: https://fitnessbodychallenge.de/crossfitmitschmackes/Du möchtest Themen einreichen? Dann schreib uns doch einfach unter support@fitnessbodychallenge. de oder auf Instagram unter @deinefbc und @crossfitmitschmackes.Wusstest du, dass dein Körper exakt dieselbe Mahlzeit völlig anders verarbeitet, je nachdem, was du zuerst isst? Wir erklären dir heute das Prinzip des „Ballaststoff-Teppichs“ und warum ein einfacher Beilagensalat vor der Pizza darüber entscheiden kann, ob dein Körper im Fettverbrennungs-Modus bleibt oder massiv Fett einlagert.Wir räumen mit dem „Suppenkoma“ auf und zeigen dir, warum das berüchtigte Nachmittagstief kein Schicksal ist, sondern das Ergebnis einer Blutzucker-Achterbahn, die du selbst steuern kannst. Außerdem entlarven wir den „Brotkorb-Trick“ im Restaurant: Warum wird uns das Brot eigentlich immer zuerst serviert und wie trickst das unseren Hunger aus?Mehr Informationen zu uns und unserer Fitness Body Challenge findest du hier: https://fitnessbodychallenge.de/crossfitmitschmackes/Du möchtest Themen einreichen? Dann schreib uns doch einfach unter support@fitnessbodychallenge. de oder auf Instagram unter @deinefbc und @crossfitmitschmackes.

In this episode of Maximize Your Hunt, Jon Teater explores advanced hinge cutting techniques, timber management, and food plot strategies to enhance wildlife habitat and hunting success. Host shares expert insights on tree selection, structure creation, and balancing timber and habitat goals. Key topics include hinge cutting techniques and purpose, tree species selection and management, creating cover and structure for wildlife, balancing timber production with habitat needs   Takeaways Mastering Hinge Cutting for Better Wildlife Habitat 10 Expert Tips for Timber and Habitat Management   Social https://whitetaillandscapes.com/ https://www.facebook.com/whitetaillandscapes/ https://www.instagram.com/whitetail_landscapes/?hl=en Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

The better you get at seeing opportunity, the worse you get at finishing anything. It turns out the same brain wiring that makes curious, growth-oriented people so interesting to talk to also makes them spectacularly bad at committing to one thing. In this episode, we explore the surprisingly rich psychology of focus — from what Taylor Swift's 16 dress changes per concert reveal about sequencing your ambitions, to a landmark study showing that how others perceive your potential literally changes what you become. It's equal parts neuroscience, life philosophy, and one man's genuine attempt to understand what wearing a dress taught him about staying focused. Why your potential is only as useful as your ability to narrow it The science behind why commitment feels like loss — and how to reframe it How to build a life with many chapters without living them all at once Funny, counterintuitive, and oddly practical — this episode might be the permission slip you didn't know you needed. SPONSORS

Send us Fan MailWhen Cash Feels Safer Than the Market: Funding Big Projects, Managing Risk, and Avoiding Tax TrapsHunter Kelly discusses a client case (names changed) involving Mark and Lauren, who earn just over $300,000, have nearly $1 million in retirement savings, and $100,000 cash while considering a $175,000–$180,000 pool project. They explored HELOC/pool loans but were uncomfortable with added debt, so they chose to delay until Mark's July bonus and retention payment arrive, including temporarily reducing his 403(b) contributions to increase short-term liquidity. The episode also covers Mark moving about $700,000 of his 403(b) into a money market due to market fears, the risks of staying in cash, and using a rules-based reentry plan and more fitting allocation. Kelly explains capital loss limits ($3,000 against ordinary income with carryforwards) and a backdoor Roth IRA reporting error on Form 8606 that, once corrected, saved about $1,000, emphasizing sequencing and broader advisor value beyond investments.00:00 Welcome and Setup00:46 Meet Mark and Lauren02:23 Pool Project Costs04:31 Debt vs Peace of Mind05:42 Waiting for Bonus Cash07:33 Pause 403b for Liquidity09:10 Moved Retirement to Cash11:56 Rules Based Reentry Plan14:08 Breakeven Bias and Purpose17:00 Capital Losses Explained19:54 Backdoor Roth Reporting23:03 Sequencing and Takeaways26:02 Wrap Up and DisclaimerCheck out the Palm Valley Wealth Management WebsitePalmValleywm.comCheck us out on InstagramLinkedIn FacebookListen to the Podcast Here! AppleSpotify

This week's show covers the sequencing of retirement withdrawals, municipal bonds, backdoor Roth contributions, gifting, and lots more!

Just briefly. Domesticated Nostalgia, should you care to listen.

In this episode, Hannah turns the mic on Celest to explore one of the most important shifts happening in modern yoga teaching: moving beyond muscles and into the nervous system.If you've ever felt stuck in your practice, confused by why something isn't improving, or unsure how to evolve your teaching, this conversation opens a completely new lens.Together, they unpack what sequencing really means from a neurological perspective, why traditional “build up to a pose” thinking can fall short, and how simple changes in input can completely transform how a body moves and feels.This is not about adding complexity. It's about understanding what's actually driving movement, safety and progress.In this episode, we explore:Why sequencing is more than arranging poses and what's actually happening in the brainThe role of sensory inputs, including vision, balance and internal awareness, in movement and performance Why strength and flexibility alone don't guarantee progress in poses like Pincha MayurasanaHow the nervous system determines whether a pose feels safe or threateningThe hidden reasons behind plateaus, asymmetries and “stuck” patternsHow past experiences, stress and injury history shape what happens on the matWhy repeating the same drills doesn't always lead to changeThe emotional and psychological layers that influence physical practiceCelest also shares her own journey from a purely biomechanical approach to integrating neuro-based work, including the challenges of learning and teaching this in real time.The conversation closes with a powerful reminder: your body is not failing you. It is responding to the information it receives.About Alba Yoga Academy⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Learn more with Alba Yoga Academy⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Learn more about our Yoga Teacher Training here.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Watch our extensive library of YouTube videos.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Follow Hannah on Instagram.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Follow Celest on Instagram ⁠⁠⁠⁠

Today, host John Norlin shares a strategy called Grandma's Rule, a practical, research-backed approach to building predictability into the classroom through first-then scheduling and visual routines. John walks through why predictable environments lead to regulation, engagement, and ultimately learning, and how educators can set this up in a way that increases student motivation from the start. This episode is part of the CharacterStrong Weekly series — short, immediately applicable strategies educators can put to work the same day. In this episode, John offers important reminders for educators and leaders: Students crave predictability, when they can anticipate what is coming and why, they are better regulated and more ready to learn. First-then scheduling makes routines visible and explicit, giving students something to reference and helping educators get ahead of behavior proactively. Sequencing preferred and less preferred activities strategically increases student motivation without requiring more time or resources. Learn More About CharacterStrong:  Access FREE MTSS Curriculum Samples Request a Quote Today! Learn more about CharacterStrong Implementation Support Visit the CharacterStrong Website

Therapy, Maintenance, and Relapsed/Refractory SequencingThis week, we kick off the first of our myeloma capstone roundtable discussions with two experts who treat myeloma every single day. We welcome back Dr. Manni Mohyuddin from the Huntsman Cancer Institute at the University of Utah, and introduce a new friend of the show, Dr. Adeel Khan from UT Southwestern. In part two, we cover three practical and rapidly evolving topics: the role of MRD testing in guiding treatment decisions, how to individualize maintenance therapy in 2026, and how to approach sequencing of CAR-T and bispecific therapies in the relapsed/refractory setting.In this week's show notes, we summarize the key thoughts about how our experts think about approach to their patients.If you have not already done so, be sure to check out Part 1 of this discussion!Content:- What are the practical implications of MRD-testing in myeloma treatment?- How do we think about maintenance therapy in the present day? - What therapies are on the horizon? - How do we approach management of younger patients with relapsed/refractory disease?- How do we approach bridging therapy? ** This episode is sponsored by Primum! To learn more, sign up for your free account, and to ask questions to Primum experts, visit primum.co/fellows. As a special bonus, one of our guests, Dr. Mohyuddin, is an expert on Primum ready for your questions!** Want to review the show notes for this episode and others? Check out our website. Love what you hear? Tell a friend and leave a review on our podcast streaming platforms!Twitter: @TheFellowOnCallInstagram: @TheFellowOnCallListen in on: Apple Podcast, Spotify, and Youtube

Points of Interest 00:01 – 02:30 – The Cost of Poor Sequencing: Marcel and Kristen introduce the core issue—agencies often apply the right tactics in the wrong order, leading to wasted effort and stalled profitability. 02:30 – 05:00 – The Insight Formula: They explain that data alone is meaningless without context, introducing the key concept that insight comes from comparing expectations to reality. 05:00 – 06:30 – Start with a Business Model: Agencies should begin by building a model of their business to define what success should look like before measuring performance. 06:30 – 08:30 – The Danger of Starting with Data: Many firms overinvest in tracking actuals first, only to realize they lack the benchmarks needed to interpret the data effectively. 08:30 – 10:30 – Why Expectations Come First: Establishing expectations is faster, requires no new data, and is essential for designing meaningful feedback loops. 10:30 – 12:30 – Misguided Pricing and Benchmarking: Agencies often rely on market benchmarks instead of internal cost structures, leading to misaligned pricing and profitability issues. 12:30 – 14:30 – Framework vs. Frankenstein Metrics: Combining disconnected industry formulas creates inconsistent and unreliable financial insights, highlighting the need for a unified framework. 14:30 – 17:00 – Forecasting as the Next Step: Once a model is established, agencies must forecast workload and capacity, starting with clear scope and effort assumptions. 17:00 – 20:00 – The Precision Trap in Forecasting: Overly detailed planning creates friction and reduces adaptability; executive-level forecasting should prioritize accuracy over precision. 20:00 – 22:30 – The Power of Forecasting Without Time Tracking: A strong forecast can provide meaningful insight even without detailed time-tracking data. 22:30 – 25:30 – Installing Feedback Loops: Feedback loops help refine assumptions and uncover operational issues by comparing planned vs. actual performance. 25:30 – 30:00 – Prioritizing Profitability Levers: Marcel outlines the correct order for improving profitability—starting with overhead (if needed), then utilization, followed by pricing (effective rate), and finally cost structure. Show Notes Connect with Kristen via LinkedIn Free Agency Toolkit Parakeeto Foundations Course Free access to our Model Platform Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this episode of the Oncology Brothers podcast, we kicked off a three-part series on colorectal cancer, starting with the current treatment algorithm. They are joined by Dr. Smitha Krishnamurthi, a GI medical oncologist from the Cleveland Clinic, who walks through the evolving standard of care from early-stage disease all the way to refractory metastatic settings. Listen us on: Spotify: https://open.spotify.com/show/31BXhY9FM4gPWG10WgE11o Apple Podcast: https://podcasts.apple.com/us/podcast/oncology-brothers-practice-changing-cancer-discussions/id1653340966 Follow us on social media: •⁠  ⁠X/Twitter: https://twitter.com/oncbrothers •⁠  ⁠Instagram: https://www.instagram.com/oncbrothers •⁠  Website: https://oncbrothers.com/ Key topics discussed included: • The evolving role of ctDNA as both a prognostic and predictive tool in stage two and three colon cancer, including its utility in oligometastatic disease surveillance. • Neoadjuvant versus adjuvant immunotherapy in MSI-high resectable colon cancer, comparing the NICHE-2 and ATOMIC trial approaches and when to use each. • Single-agent versus dual checkpoint inhibition with Nivo-Ipi for MSI-high metastatic disease, based on CHECKMATE-8HW data showing a PFS hazard ratio of 0.21. • Sequencing strategies in RAS-mutant and RAS wild-type metastatic colorectal cancer, including the role of sidedness, anti-EGFR therapy, and refractory options like fruquintinib, TAS-102, and regorafenib. Join us for this comprehensive discussion on colorectal cancer management in 2026. Don't forget to like, subscribe, and check out our other episodes for more insights on oncology! #ColorectalCancer, #MSIHigh, #BRAFV600E, #ctDNA, #GIOncology, #OncologyBrothers

Dylan Lew, co-founder and CEO of Ecotone, chats with Scott Hartley, GP of Everywhere VenturesIn episode 114 of Venture Everywhere, Scott Hartley, managing partner at Everywhere Ventures, talks with Dylan Lew, co-founder and CEO of Ecotone Renewables, a company replacing traditional waste hauling with on-site biodigesters that convert commercial food waste into a locally distributed organic fertilizer. Dylan shares how building and operating an early digester that broke down constantly pushed him to rethink the entire food waste system from the ground up. He discusses how Ecotone is rewriting the economics of food waste management, turning what businesses write off as a disposal cost into a revenue stream and a locally sourced fertilizer supply chain.In this episode, you will hear:Using state food waste bans to landfill as a distribution accelerant.Building a decentralized grid of on-site digesters over centralized facilities.Upcycling commercial food waste into a locally distributed organic fertilizer.Expanding from digester hardware to AI-powered waste intelligence.Sequencing a multi-sided business from digester manufacturing to retail fertilizer.Learn more about Dylan Lew | Ecotone RenewablesLinkedIn: https://www.linkedin.com/in/dylan-lew412Website: https://www.ecotonerenewables.comLearn more about Scott Hartley | Everywhere VCLinkedin: https://www.linkedin.com/in/scotthartleyWebsite: https://everywhere.vc/

Leisa, former Head of Research and Insights at Atlassian, reflects on how AI is changing the UX research industry. She discusses how vibe-coding helps shift from traditional project sequencing to faster, more iterative build-measure-learn cycles and how that impacts the role of UX research in organisations. Leisa expounds on her positive attitude towards AI, saying that the unique value of researchers will shift toward filling the "judgment gap" with deep, longitudinal human observation that machines simply cannot replicate.

Most people fail to achieve long-term goals because their goals stay foggy, vague, not deconstructed, sequenced, selected and kept accountable.Achievement that lasts has very little to do with talent and everything to do with the process.When “get healthy,” “become a better leader,” or “grow my business” is still a blurry vision, it's almost impossible to know what to do on any day, let alone what to track, what to practice, and what to improve. And how to put the whole thing together.I walk you through one of the most fundamental coaching skills I use with clients: deconstruction (goal decomposition). We take any complex goal and break it into smaller, defined milestones and trainable subskills you can act on today. I ground it with a practical health example using the big four pillars of well-being: sleep, nutrition, exercise, and stress management, plus the real subskills inside nutrition like meal planning, protein, hydration, and emotion regulation.Then I bring in Tim Ferriss's DISSS learning framework: Deconstruction, Selection, Sequencing, and Stakes. We talk about the 80/20 rule (Pareto principle) so you focus on the few actions that create the biggest return, how to sequence skills so you're not “building a tabletop with no legs,” and why stakes and accountability are the difference between ideas and results. I also share how to use AI tools like ChatGPT or Claude to identify components, prioritize the high-leverage pieces, and draft a plan you can schedule and measure.If you want better goal setting, skill building, and a simple system for personal growth that actually works in real life, hit play and share it with someone who needs it.  Text Me Your Thoughts and IdeasSupport the showBrought to you by Angela Shurina  Behavior-First, Executive, Leadership and Optimal Performance Coach 360, Change Leadership & Culture Transformation Consultant  

Photojournalism With Cengiz Yar From High School Hobby to War Zones: Self‑Care Secrets & the Story Behind This Alabaster Grave

Block schedules offer the promise of more time, but without intentional design, that time doesn't always translate into deeper learning. In this episode, I unpack common missteps like stacking and stretching traditional lessons and why they often lead to cognitive overload, disengagement, and fatigue. I explore how to shift from filling time to intentionally sequencing learning with purposeful content blocks that move students from passive to active participants. If you're teaching in a block schedule, this episode will help you design that time so it actually works for you and your students.

In today's episode of OncLive On Air®, Jonathan Trent, MD, PhD, and Neeta Somaiah, MD, sat down to discuss the evolving role of circulating tumor DNA (ctDNA) testing in gastrointestinal stromal tumors (GIST), as well as the importance of identifying both initial drivers of disease and secondary resistance mechanisms when approaching frontline treatment selection and overall therapeutic sequencing.Trent is a professor of medicine, associate director of Clinical Research, and director of the Sarcoma Medical Research Program at the University of Miami Miller School of Medicine, in Florida. Somaiah is a professor and chair of the Department of Sarcoma Medical Oncology in the Division of Cancer Medicine at The University of Texas MD Anderson Cancer Center in Houston.Drs Trent and Somaiah began their discussion by highlighting the rarity of GIST, underscoring the importance of evaluation at specialized sarcoma centers and comprehensive molecular testing to identify driver alterations.Somaiah then reviewed the molecular landscape of GIST, noting that approximately 70% to 80% of tumors harbor activating mutations in the KIT gene, while additional cases involve rarer alterations such as BRAF or NTRK fusions. Of note, resistance to imatinib (Gleevec) frequently emerges through secondary mutations in KIT exons 13 or 17, which can influence sensitivity to subsequent TKIs.ctDNA testing may help detect these resistance mechanisms, particularly at progression or when tissue is limited, enabling clinicians to refine sequencing strategies, both experts explained. They also discussed how mutation-informed approaches may guide treatment selection, including emerging strategies such as combining sunitinib (Sutent) with bezuclastinib to address resistant clones involving KIT exon 13 or 17 alterations.This content is a production of OncLive; this OncLive On Air podcast episode is supported by funding, however, content is produced and independently developed by OncLive.

Today we explore the difference between founder CEOs and corporate CEOs, and why a founder's energy can either inspire a team or overwhelm it. We focus on the leadership discipline of turning creativity into clear priorities so the organization can execute without constant whiplash.In this episode you will learn:• Difference between founder CEO and corporate CEO structures• Founder energy shaping culture and day-to-day direction• Why scattered ideas create confusion as teams scale• Saying yes to opportunities and the hidden cost to focus• Examples of initiative overload after conferences• Sequencing initiatives so creativity supports executionIf this episode was useful, follow Elite Achievement to continue building clarity and execution into how you work.Work With KristinKristin partners with business owners and leaders as a thought partner, asking the questions that create clarity, challenge assumptions, and move clients from emotion back into execution.Learn more about private coaching at kristinburke.com.Connect with KristinLinkedInWebsiteGoal Setting Success Course

Dynasty Trade Stair Stepping, Christian Kirk to the 49ers, and the Seahawks as a lynchpin NFL Draft team. Get 500+ premium podcasts by signing up at www.UTHDynasty.com as a General Manager PLUS subscriber. Also, get access to exclusive shows and deep data dive content from Chad Parsons (and a VIP Chat with the best dynasty owners on the planet) by signing up as an All-Pro at www.Patreon.com/UTH. Thanks for listening, and keep building those dynasties! Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Yoga is often perceived as a recovery tool for athletes, but that barely scratches the surface of what yoga can offer active people.  In this episode, hosts Tiffany and Rachel explore the many roles yoga can play in athletic cross-training. They discuss how yoga can be used to not only maintain range of motion and provide tools for nervous system recovery, but also to balance repetitive movement patterns and support overall performance. Listen in to learn how cross-training with yoga supports longevity—not just in sports, but in life. Whether you're a runner, cyclist, desk worker, recreational athlete, or parent, incorporating yoga can help you move better, recover more effectively, and continue doing the activities you love for years to come. "As humans, we want to be able to live the full expression of our lives… it really is about optimizing how we feel and function in our lives." — Tiffany Cruikshank. — What You'll Learn: Cross training: the big picture [1:38] How yoga can help [7:23] Cross training and injury reduction [10.51] Sequencing a cross training yoga practice: Breath work, body awareness, isometrics, MFR [12:25] Finding the right level & type of challenge [15:11] Mobility work [16:39] Nervous system regulation [17:45] Active recovery [18:11] Myriad yoga techniques to draw from [19:32] The goals of yoga for cross training: Maintaining mobility and ROM [21:10]
 Support performance and muscular balance, provide variety [21:58]
 Nervous system support, rest, and recovery [24:18]
 Be flexible when teaching yoga cross training classes [26:16]
 The central goal of cross training: longevity of sport and long-term functionality in life [28:30 Key factors to keep in mind [37:28]
 The Yoga Medicine Yoga for Athletes Training [41:50]
 — Links Mentioned: Watch this episode on YouTube  Yoga Medicine Yoga for Athletes Teacher Training — Learn More: Find the full show notes at YogaMedicine.com/podcast-162. Learn more about insider tips, online classes or information on our teacher trainings at YogaMedicine.com. To support our work, please leave us a 5 star review with your feedback on iTunes/Apple Podcasts or wherever you listen to podcasts. 

Most yoga teachers are taught that sequencing should be creative, complex, and always different. But these common beliefs often making teaching harder -- and keep both teachers and students stuck.Support this show http://supporter.acast.com/yogaland. Hosted on Acast. See acast.com/privacy for more information.

In this podcast, experts Christine M. Lovly, MD, PhD, FASCO; Lyudmila Bazhenova, MD; Hossein Borghaei, DO, MS; and Xiuning Le, MD, PhD, discuss how to sequence systemic therapy based on the molecular profile of non–small cell lung cancer that has progressed on a first-line EGFR-directed tyrosine kinase inhibitor, including discussion on the use of bispecific antibodies in this setting.

If you are both lifting weights and doing cardio, is your program optimizing for both without undermining each other?It's not that combining them is bad, but that most people struggle to arrange their training week.Philip walks through the 5 programming mistakes that create interference between your strength training and your conditioning, using the new Velocity 5-day Hybrid program from Physique University as the example of what it looks like when you fix all five.You'll learn when to program your heaviest lifts, which days your sprint intervals should go on, how and when to use a dedicated "active recovery" day, and when to skip the extra conditioning work instead of pushing through it.If you've been trying to build muscle, lose fat, and improve your cardio fitness at the same time and feel like neither one is progressing, this episode will show you where to look first.Cozy Earth bamboo pajamas and blankets | Your training is only as good as your recovery. Cozy Earth's temperature-regulating bamboo pajamas and Classic Cuddle Blanket help you actually rest when you're done for the day. 100-night sleep trial, 10-year warranty. Go to witsandweights.com/cozyearth and use code WITSANDWEIGHTS for up to 20% off.Join Physique University (Velocity + 10 other training templates): physique.witsandweights.comEpisodes MentionedStrength Training and Endurance Together (Without Killing Your Gains)Are Your Fitness Goals in Conflict?Timestamps0:00 - Lifting vs. cardio (does hybrid training create interference?)  4:55 - Mistake 1: Timing of cardio vs. heavy lifts 6:51 - Mistake 2: Superset pairings and muscle fatigue 8:28 - Mistake 3: Putting sprint intervals on the wrong days 10:27 - Mistake 4: To "active recovery" or not? 14:18 - Mistake 5: Doing THIS with every conditioning session 15:45 - Recovery starts with better sleep 17:00 - How the full training week fits together 19:33 - Sequencing vs. exercise selection 20:44 - Velocity 5-Day Hybrid Training program 22:32 - The 60-second hybrid program audit

Carolyn McMakin, MA, DC - https://frequencyspecific.com     Kim Pittis, LCSP, (PHYS), MT - https://fsmsports365.com 00:00 Brain Plasticity Basics 00:50 Podcast Intro and Hosts 02:21 Treatment Layers Setup 03:02 Complex Trauma Case 07:06 Vagus and Neuroplasticity 12:25 Energy Centers and Terror 16:21 Aftercare and Results 20:40 Physical Exam First 23:18 Emotions Stored in Fascia 29:05 Safety Disclosure and 40/89 32:46 Listener Q and EDS Case 33:18 Hypermobile Teen Protocol 35:44 Upper Cervical Rehab Plan 37:22 Avoiding C1-C2 Fusion 38:21 Treatment Schedule Expectations 39:25 Infant Seizures and Viruses 42:55 Post-Concussion Vision Fatigue 46:43 Scarring and Hypermobile Care 47:25 Calcium Nodule Case Report 50:00 Macular Degeneration Scope 52:42 Wrap Up and Disclaimers **Enhancing Brain Plasticity and Patient Outcomes** The journey towards improving patient outcomes is multifaceted and often requires approaches that go beyond conventional physical exams. One vital aspect that practitioners can explore is the integration of emotional frequencies into treatments aimed at enhancing brain plasticity. To increase brain plasticity, it's essential to facilitate the secretion of beneficial neurochemicals through the vagus nerve. By doing so, medical practitioners can leverage the vagus nerve's ability to regulate various body functions, including the inflammatory response, emotional balance, and even the growth of nerve fibers. This holistic approach is crucial, especially when dealing with cases involving trauma, both physical and emotional. **The Role of Sequencing in Treatment** When administering treatments, it's not uncommon to encounter practitioners who prioritize emotional frequencies right off the bat. However, the foundation of a successful treatment plan lies in acknowledging and addressing the physical condition first. Physical examinations, including range of motion, reflex, and sensory tests, allow practitioners to chart objective progress, which is an indispensable part of comprehensive patient care. Once the physical aspects are addressed, practitioners can begin to layer in emotional frequencies. This sequencing is crucial for harnessing the patient's energy effectively and directing it towards healing. The principle here is that unresolved emotional energies can redirect the body's healing capacity, thus delaying recovery. By systematically navigating through these layers—ranging from fear and anger to grief and joy—practitioners can aid in unblocking stored emotions, thereby promoting holistic healing. **Techniques for Addressing Complex Patient Histories**  In cases where patients present complex histories, such as early childhood trauma compounded by recent medical issues like COVID or stroke, a multi-machine, multi-frequency approach may be warranted. For instance, targeting the midbrain with specific frequencies, addressing scarring in the vagus nerve, and focusing on regions prone to trauma can yield significant improvements. These treatments can lead to observable changes, such as visual and vestibular corrections, which highlight the interconnected nature of physical and emotional health. By increasing neurochemical support through techniques like increasing axonal growth factors, practitioners can help rebuild neural pathways and improve patient conditions—sometimes even reversing the sense of imbalance within the body. **Navigating Emotional Frequencies with Precision** Medical practitioners should be equipped to introduce emotional frequencies into their regimens with precision. The fascia, likened to a jump drive, stores these emotions; thus, treating emotions that are trapped within the fascia involves quieting the brain regions that store them. 

You said, "That sounds really hard," so why is your partner still upset? It's called the Empathy Dash — that moment you touch your partner's pain just long enough to check a box, then sprint toward solutions, silver linings, or your own experience. In over 1,500 couples sessions, Tony has watched this pattern quietly erode trust while both partners swear they're trying. This episode unpacks why your empathy isn't landing, what your nervous system is actually doing when you rush to fix, and a deceptively simple practice that changes everything. In this episode, you'll discover: Why "me too" on the inside lands like "not you" on the outside — and the intent-vs-impact gap where relationships slowly erode Stealing Thunder: the real-time couples session moment that perfectly captures how sharing gets hijacked before it even lands How your Adaptive Child — the survival strategy that kept you safe growing up — is now sabotaging your closest relationship The neuroscience of co-regulation and why your calm presence does more than your best advice ever could The 3-Before-1 Rule: a concrete practice for staying present when every instinct says fix, solve, or flee Tony Overbay, LMFT, draws from over two decades of couples therapy, Terry Real's relational framework, and Dan Siegel's interpersonal neurobiology to redefine what empathy actually looks like in practice. If you've ever left a conversation thinking "I said all the right things" while your partner felt completely unseen — this one's for you. You're not broken. You just don't know what you don't know yet. 00:00 Welcome and Where to Follow 01:15 Retreat Story Mental Load Misfire 04:56 Intent vs Impact in Bids 06:08 Attack Surface and Pathological Kindness 09:37 Sequencing the Conversation 12:26 Stealing Thunder Named 17:02 Catching the Thunder Grab 18:17 Drive By Empathy Metaphor 21:03 Empathy vs Sympathy Basics 22:36 Why Optimism Can Dismiss 24:02 What Empathy Actually Does 26:58 Real Life Fixing Examples 28:39 Spotting the Empathy Dash 29:30 Why We Do It 30:12 Adaptive Child Origins 31:39 Fixer vs Avoider Examples 33:49 Co-Regulation Explained 34:44 Two Ways to Respond 37:16 Four Pillars Framework 38:11 Questions Before Comments 38:58 Curiosity in Action 42:19 Three Before One Rule 45:40 When Effort Feels Unseen 47:35 Handling Your Triggers 49:27 Closing Encouragement Get on the waitlist today for Tony's upcoming Magnetic Marriage live course! Head to https://tonyoverbay.com/magnetic Contact Tony at contact@tonyoverbay.com to learn more about his Emotional Architects men's group.

In this episode, we're talking about sequencing mistakes - the common ones, the subtle ones, and the ones we definitely made ourselves.Of course, sequencing is subjective. But after years of teaching, training teachers, leading retreats, and building classes that actually retain students, we've noticed patterns. Certain choices tend to create stronger classes, deeper learning, and more trust in the room. And certain habits… quietly work against you.We unpack what happens when you do too much too soon, move too quickly, or walk into class without a clear intention. We talk about over-sequencing one side, changing your class every single week, teaching from ego instead of awareness, and why nervous system regulation matters more than flashy transitions.We also dive into:• Warming up slowly (and why most teachers don't)• Having a plan without being rigid• Simplifying instead of stacking endlessly• Setting a pace that actually matches the breath• Not disorienting your students (they want to feel held, not confused)• Why demoing the entire class might be disconnecting you• How to keep things balanced without overdoing one theme or peakThis episode is honest, practical, and slightly confrontational in the best way. If you're a teacher who wants stronger classes and more grounded students, or a student curious about what's happening behind the scenes, this one's for you.Want to support our podcast? Join our Patreon for extra content** CHECK OUT OUR 300-HOUR PROGRAM **

I see teams struggle with the flow of value because they are either bogged down in the stories and tasks or they don't have a candle in the dark room.Hey Product Owner, you have to light that candle and show them the way.If prioritization seems like a never-ending battle or even worse you are prioritizing the wrong backlog - yes - you know the one...Then this episode is for you!This episode is great for product owners, new and old. But not just for you! Agile leaders, scrum masters, dev teams and project managers could probably steal some things from this one.Kickin it old school on this one!www.planetproductowner.org is being updated.The tests are over. Coming soon!!

On this week's podcast, Jason outlines why the old models of yoga sequencing are no longer effective in today's landscape. To name a few: More people cross-train. Fewer students are walking into studios. ClassPass has changed loyalty. Online platforms have shifted expectations. If you want better student retention, stronger engagement, and a more sustainable yoga teaching career, this conversation is essential.⸻⏱ Highlights2:23 Sequencing 2.0 — What's New6:00 The Two Traditional Sequencing Models6:57 The Problem with Fixed Sequences8:07 The Problem with Random Classes13:29 Why Student Retention Is Harder Now20:39 Online Teaching & Retention29:50 ClassPass & (the lack of) Loyalty35:19 The Solution: Monthly Progressions35:33 How to Build Skill Over Time⸻Jason shares why consistency and novelty must coexist, how to use month-long progressions, how to think like an educator, and how we can help students build skills, helping to build student retention. to maintain retention. If you're serious about becoming a more effective and modern yoga teacher, it's a must-listen! Hosted on Acast. See acast.com/privacy for more information.

You track your food. You lift. You can explain why protein matters for building muscle. So why hasn't your body changed? The gap between knowing what to do and getting results is not a discipline problem. It's a structure problem. And more nutrition and fitness information won't fix it.Philip breaks down what's actually missing for experienced lifters over 40 who have tried multiple programs and still feel stuck. Drawing intake data from hundreds of coaching clients, he explains why conflicting advice creates rational paralysis, why 49% of knowledgeable lifters still struggle with the basics, and the 3 specific things (sequencing, context, and feedback loops) that separate people who know what to do from people who get results. He also covers why this gap hits harder after 40, when hormonal shifts from perimenopause, menopause, and declining testosterone shrink the margin for error on both strength training and nutrition.If you've been doing "all the right things" and your body composition hasn't budged, this episode will reframe what's actually standing in your way, and what an effective solution looks like.Join the Eat More Lift Heavy waitlist to be the first to hear about a brand new structured asynchronous coaching process built for experienced lifters who have the knowledge but need sequencing, context, and feedback loops to finally close the gap between knowing and doing:https://witsandweights.com/eatmoreTimestamps0:00 - Knowing vs. doing (the real reason you're stuck) 2:02 - The information trap in nutrition and fitness 6:45 - Conflicting advice and analysis paralysis 11:25 - What's actually missing (it's not discipline) 14:30 - Sequencing: why 1 change per week beats 50 19:10 - Why generic plans fail lifters over 40 23:20 - Building feedback loops for your training and nutrition 27:10 - Structured asynchronous coaching 28:30 - What good coaching actually looks like 36:20 - The middle ground that barely exists in fitness

In today's episode, we welcomed Quinto Gesiotto, MD, a malignant hematologist at Tampa General Hospital in Florida.In the exclusive interview, Dr Gesiotto explored the evolving role of TKIs in the treatment of patients with chronic myeloid leukemia (CML), including dosing patterns for ponatinib (Iclusig) in those with CML and other TKI data to emerge in the CML space at the 2025 ASH Annual Meeting and Exposition. Dr Gesiotto also provided detail on emerging data on novel strategies and agents, along with genetic mutations beyond BCR-ABL1 T315I the could drive more personalized treatment sequencing and improved risk stratification in CML in the future. 

The City Bar's Presidential Task Force on AI and Digital Technologies hosts today's podcast on President Trump's:  Winning the Race, America's AI Action Plan. Task Force co-chair Jerome Walker is joined by task force members Matthew Bacal (Davis Polk), Azish Filabi (American College of Financial Services), Robert Mahari (Stanford Codex), and Evan Abrams (Steptoe), to review the plan's three pillars and key action steps. Pillar One (“Accelerate AI Innovation”) is described as largely deregulatory, including agency review of rules and certain FTC/FCC actions, with targeted concerns such as ideological bias and synthetic media in the legal system, plus investments in open-source/open-weight models, data, interpretability, evaluations, and government/DoD adoption. Pillar Two (“Build American AI Infrastructure”) focuses on the physical side of AI—permitting for data centers and fabs, energy and grid expansion, semiconductors, water for cooling, workforce training, cybersecurity, and “security by design,” while anticipating trade-offs and litigation. Pillar Three (“Lead in International AI Diplomacy and Security”) balances support for exporting US “full stack” AI with tighter national security controls, including stronger export-control enforcement and participation in international bodies primarily to counter China. The conversation closes with suggestions for improving the plan by strengthening trust, safety/rights considerations, and maintaining flexibility as AI capabilities evolve. If you are interested in learning more about emerging AI developments and policy, join us for the 2026 Artificial Intelligence Conference on June 18 to hear from industry experts and connect with leading legal professionals across the field. 00:00 Trump's 2025 AI Action Plan: Big Goals, Short Document, 3 Pillars 03:23 Pillar One Preview: 15 Action Steps to ‘Accelerate AI Innovation' 09:16 Meet the Panel + Setting Up the Pillar One Deep Dive 11:21 Pillar One Explained: Deregulation, Free Speech, Data Sharing, Evaluations, and Trust 18:33 Key Takeaways for Stakeholders: Business, Finance, Civil Society, and Tech 23:57 Which Pillar One Steps Matter Most? Sequencing, Competitiveness, and Data Access 27:52 Pillar Two: The Physical Side of AI—Energy, Chips, Data Centers 36:32 Critical Infrastructure Security: Physical Risks, Cyber Threats & ‘Security by Design' 37:14 Data Poisoning Explained: How Training Data Can Be Manipulated at Scale 38:00 Workforce Training at Scale: From Trades to Semiconductor Talent Pipelines 38:52 Wrapping Pillar Two: China Competition, Speeding Projects, and Ranking Priorities 40:34 What Lawyers & Judges Need to Know About Pillar Two (Red Tape, Legal Tech, Litigation) 45:30 Pillar Three Overview: Balancing Global AI Leadership with National Security Controls 50:05 Pillar Three Priorities by Industry: Export Controls, Frontier Evaluations & Data Center Risk 58:56 Why Engage International AI Bodies? Countering China and Filling the Leadership Vacuum 01:03:20 Trump vs. Biden Narratives: Competition vs. Safety—What Should Change in the Plan? 01:07:38 Panel Advice to Improve the Action Plan: Rights Framework, Nimble Policy, Safety & Research Funding

On this episode of Data Dump, we break down the numbers behind Tomoyuki Sugano and José Quintana — and what the data says about their 2026 outlook.Recorded on 2/11/26Sugano arrives with elite command, pitchability, and years of dominance overseas. But how does his arsenal translate? We dive into his pitch mix, strike-throwing profile, whiff rates, and what comparable MLB arms tell us about his ceiling at altitude.Quintana, meanwhile, continues to defy aging curves. Is it smoke and mirrors? Soft contact mastery? Sequencing? We analyze his underlying metrics — K-BB%, ground ball rate, contact quality, and road/home splits — to determine whether his success is sustainable or regression-bound.Subscribe for weekly Rockies analytics breakdowns.#ColoradoRockies #DataDump #TomoyukiSugano #JoseQuintana #MLBAnalytics #RockiesBaseball #BlakeStreetBanter

We visit Plasmidsaurus and spoke with CEO Mark Budde about why they are offering sequencing for so cheap, what surprises came up when their customers first got whole plasmid sequencing, and how sequencers are like bread machines. Join the discussion in the comments on YouTube: https://youtu.be/Ss8H6VUQBGo Where to find us online: https://omgenomics.com

In this part 2 of a 4-part podcast series, you'll discover more of what builds confident yoga teaching. It's a combination of having a solid approach to cueing, sequencing, to understanding the fundamentals of anatomy and having a confident mindset. In today's episode, you'll hear about a sequencing approach that will help you feel more confident in the sequence you offer, take less time to prepare for your classes and allow you to stand out as a yoga teacher:    I mention a training video that shares more on sequencing and you can get that here:   https://barebonesyoga.lpages.co/how-to-create-a-signature-sequence/   If you're curious about the training program I mentioned, you can check out my program here:   https://barebonesyoga.thinkific.com/courses/Yoga-Anatomy-Accelerator

Drs. Coombs and Danilov explore how to optimally sequence covalent BTK inhibitors, non‑covalent BTK inhibitors (such as pirtobrutinib), and venetoclax-based regimens for relapsed CLL, emphasizing real-world data and emerging trial results. They highlight that treatment choices hinge on prior response depth and duration, tolerability, mutational profile, and the need to preserve future options and clinical trial eligibility.

Sequencing doesn't start with themes or peak poses, it starts with understanding the pose itself. In this episode, I introduce pose literacy and explain why it's the missing link behind clearer, safer, and more intelligent sequencing. Using Downward-Facing Dog as a real example, I break down how learning to read a pose beyond alignment can completely change how you teach, sequence, and support your students.Episode Highlights:Why modern sequencing often skips the most essential stepWhat pose literacy is, and why alignment alone isn't enoughHow low pose literacy leads to guesswork, overload, and unsafe sequencingA pose-literacy breakdown of Downward-Facing DogHow a pose-first approach transforms sequencing and teaching confidenceWaitlist for the Online 300-Hour Yoga Teacher Training (launching January)Sequence Smarter – The Living Body of AsanaFor teachers living in India, reach out to Janessa at admin@ahamyoga.com for special local pricingJoin our mailing listFind all the resources mentioned in this episodeConnect with us on Instagram

Episode Description:This second installment of “From the Archive” returns to James's early, unfiltered conversation with Tim Ferriss. They unpack how to market by creating newsworthy moments (including a frigid book-launch fiasco turned lesson), how to learn anything using Tim's DISS framework (Deconstruction, Selection, Sequencing, Stakes), and why “possibility is negotiable” when you seek outliers and test assumptions. Tim explains fear-setting, slow-play networking that leads to real mentors, and the origin story of BrainQUICKEN → BodyQuick, including direct-response tactics, offline ads, and early UFC sponsorships. The through-line: run small experiments, protect your best energy, and stack skills to raise your odds.What You'll Learn:How to engineer “newsworthy” launches and recover from execution misses without losing momentum.The DISS method for rapid learning (Deconstruction, Selection, Sequencing, Stakes) you can apply to languages, poker, orFear-setting, not goal-setting: define worst-case scenarios, prevention steps, and recovery plans to make bolder moves.Mentors without asking “be my mentor”: add value first, build loose ties, and let a few relationships compound.From side-hustle to exit: repositioning, channel selection (including print/radio), and why out-of-fashion inventory can be a bargain.Timestamped Chapters:[02:20] A launch-day disaster in 10° weather—and the customer-recovery playbook.[05:00] “Possibility is negotiable” vs. the default “probable” path.[06:57] Finding mentors by learning before earning: the slow-play relationship strategy.[10:00] Optionality: the angel-investing analogy for career and mentors.[14:00] The DISS framework for learning anything.[18:50] Hunt the outliers: why “who shouldn't be good at this—but is?” unlocks technique.[24:30] Fear-setting: risk = likelihood of an irreversible negative outcome.[26:20] Micro-experiments to de-risk big transitions.[27:24] Secret origin: BrainQUICKEN → BodyQuick; from nootropics to non-stimulant pre-workout.[31:55] Repositioning, targeted niches, and early UFC placements.[33:13] Don't ignore “old” channels: print and radio as arbitrage.[33:55] Burnout, one-way ticket to London, and systems that led to a sale.[40:36] Title testing (and red herrings) in publishing.[46:16] The 4-Hour Workweek started by accident [52:14] Publishing myths: how “impossible” ideas become inevitable [01:07:58] TV vs. podcasting: control, constraints, and creative freedom [01:31:34] Investing: bet on people (the beer test + mall test) Additional Resources:Tim Ferriss — official site/podcast hub: tim.blog • The Tim Ferriss ShowThe 4-Hour Workweek (Expanded & Updated): Amazon listingThe 4-Hour Body — official site: fourhourbody.comThe 4-Hour Chef — official site: fourhourchef.comThe 4-Hour Workweek — official site: fourhourworkweek.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

A deep dive into yoga sequencing, what it actually is, why it matters, and the most common mistakes yoga teachers make when planning classes, I break down the difference between choreography and intentional sequencing, explore the role of the pranic and nervous systems, and share nine sequencing missteps to avoid for safer, smarter, and more sustainable teaching. This episode is especially relevant for yoga teachers who want to build confidence, longevity, and depth in their classes.Episode Highlights:What is sequencingWhy sequencing is a skill, not a formulaWhat yoga sequencing truly means beyond pose choreographyHow thoughtful sequencing supports safety, longevity, and nervous system regulationThe role of structure, progression, intention, and integration in class planningWhy sequencing shapes the energetic and pranic arc of a classHow intelligent sequencing builds trust, confidence, and professional credibilityThe 9 Sequencing Mistakes to Avoid:Treating sequencing as simply linking poses togetherOver-focusing on peak poses at the expense of purposeSkipping joint preparation and intelligent warm-upsOverloading classes with too many posesNeglecting counter-poses and proper class closureDesigning sequences based on personal preference instead of student needsIgnoring the energetic arc and pranic systemForcing philosophy or over-theming without embodimentFailing to teach toward longevity and sustainable practiceWaitlist for the Online 300-Hour Yoga Teacher Training (launching January)Sequence Smarter – The Living Body of AsanaFor teachers living in India, reach out to Janessa at admin@ahamyoga.com for special local pricingJoin our mailing listFind all the resources mentioned in this episodeConnect with us on Instagram

James Clear is an expert on behavioral change and habits and the author of the bestselling book Atomic Habits. We discuss the best ways to build new healthy habits and end bad ones without relying on motivation or willpower. Rather than list off categories of tools or acronyms, James explains how anchoring the changes you want to make in your identity and physical environment allows you to make desired changes quickly and ones that stick. Whether your goal is better fitness and physical health, productivity or mental health, you'll learn actionable, zero-cost protocols to build powerful and meaningful habits. Sponsors AG1: https://drinkag1.com/huberman Lingo: https://hellolingo.com/huberman Wealthfront*: https://wealthfront.com/huberman Joovv: https://joovv.com/huberman Eight Sleep: https://eightsleep.com/huberman Function: https://functionhealth.com/huberman Timestamps 00:00:00 James Clear 00:02:57 Common Habits, Tool: Habit Success & Getting Started 00:06:16 Make Starting a Habit Easier, Tool: 4 Laws of Behavior Change 00:10:18 Sponsors: Lingo & Wealthfront 00:13:26 Writing Habits, Seasons & Flexibility; Adaptability, Tool: Bad Day Plan 00:18:42 Consistency, Flow vs Grind, Master Showing Up, Learning & Practice 00:24:54 Chunking, Getting Started at Gym 00:28:01 Flow Don't Fight, Dissatisfaction & Effort, Tool: Identity-Based Habits 00:34:10 Friction, Competition & Effort; Credentials 00:39:38 Make Effort Rewarding, Mindset, Tools: Previsualization, Emphasize Positives 00:45:59 Sponsors: AG1 & Joovv 00:48:56 Reflection & Learning, Tool: Self-Testing; Perfectionism, Tool: Curiosity 00:55:18 Striving vs Relaxation, Balance, Tool: Turn On/Off; Hiking, Nature Reset 01:04:20 Identity & Professional Pursuits; Choosing New Projects; Clinging to Identity 01:14:24 Sponsor: Eight Sleep 01:15:42 Criticism; Identity & Growth 01:21:47 Failure, Identity, Sports, Tool: Rebounding & Reaching; Public Failures 01:30:03 Daily Habits, Tools: Day in Quarters; Never Miss Twice; Meal Timing 01:38:22 Daily Habit Timing & Sequencing, Tool: Mindfully Choose Inputs 01:45:37 Creativity, Specialization vs Generalization; Books 01:51:31 Sponsor: Function 01:53:18 Habits & Context, Environmental Cues, Tools for Minimizing Phone Use 02:02:01 Bad Habits, Checking Phone, Tools for Breaking Bad Habits 02:08:21 Physical & Social Environment, New Habits, Tool: Join/Create Groups 02:18:40 Family, Habits; Kids & Parenting, Tools: Stimulus; Good Conditions 02:26:05 Impact of Habits, Habits as Solutions; Upcoming Projects 02:32:45 Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter *This experience may not be representative of other Wealthfront clients, and there is no guarantee of future performance or success. Experiences will vary. The Cash Account, which is not a deposit account, is offered by Wealthfront Brokerage LLC, member FINRA/SIPC.  Wealthfront Brokerage is not a bank. The base APY is 3.50% on cash deposits as of November 07, 2025, is representative, subject to change, and requires no minimum. If eligible for the overall boosted rate of 4.15% offered in connection with this promo, your boosted rate is also subject to change if the base rate decreases during the 3 month promo period. Funds in the Cash Account are swept to program banks, where it earns the variable APY. New Cash Account deposits are subject to a 2-4 day holding period before becoming available for transfer. Investment advisory services are provided by Wealthfront Advisers LLC, an SEC-registered investment adviser. Securities investments: not bank deposits, bank-guaranteed or FDIC-insured, and may lose value. Learn more about your ad choices. Visit megaphone.fm/adchoices