In genetics and biochemistry, determining the structure of an unbranched biopolymer
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In this eye-opening episode of The Joe Cohen Show, Joe sits down with microbiologist and biotech entrepreneur Kiran Krishnan to dismantle the myths and marketing hype surrounding microbiome testing. Drawing parallels between the DNA and microbiome industries, they expose the scientific shortcuts, technological flaws, and misleading health claims being sold to consumers.Krishnan, the mind behind one of the few microbiome platforms used in published research, breaks down what a legitimate test looks like and why most tests on the market fall short, sometimes by as much as 70% in accuracy. The conversation also explores probiotics in depth, why strain specificity matters, and how consumers can make more informed decisions when navigating this complex and evolving space.Whether you're a health professional or someone trying to optimize your gut, this episode will help you separate science from sales.
予算カット、２年ルールWaiver、資産運用への影響、メールでのコミュニケーションなど。論文紹介は、実装が簡単な高速FLIMと、Sequeincing by expansion (4/9収録)Show Notes (番組HP):渦中のハーバード(pdf)コロンビアのNIHグラント停止Hiring Freeze Announcementデモに参加したらビザ停止Stand Up For ScienceTwitterで告知2年ルールのWaiver濱崎さん回401(k)iDeCoReddit: Fire Flow Chart Version 4.3Reddit: 401(k) max vs mortgage payment三権分立の憲法への反映はアメリカが先五十嵐さん回 1 2 3 4NSFはFellowshipを出す数が半分にRedditに降臨２ちゃんに柳沢先生ご本人登場マウスも毛むくじゃらにのプレプリント狼復活論文紹介論文１：Absolute measurement of fast and slow neuronal signals with fluorescence lifetime photometry at high temporal resolutionSabatini (弟) ラボ安田さん回Jablonski図Time DomainでのFLIM計測のわかりやすい図 (pdf, これの7ページ目)Frequency Domainとの比較に使った図 (pdf)注:PMTからのシグナルも位相をズラすと返答してしまっていますが間違いです。(萩)Fiber Photometry を流行らせたのはDラボロックインアンプFLIM用のcAMPセンサーWash UのYao ChenCholinergicセンサーFLIM転用Becker & HicklのFLIMInstant FLIM前にSabatiniラボのプレプリントを読んだ回David AndersonのState論文、たとえば 1 2 3脳の温度は結構変わるpHも睡眠とかで変わる未来予想回齋藤さん回 1 2 3論文２：Sequencing by Expansion (SBX) – a novel, high-throughput single-molecule sequencing technologyナノポアレビューDpo4CMOSによる並列化の例ONTのNanoporeONTを使ったリード精度benchmark研究階段状の建物元根さんProtein Sequencing日本語解説本社のプレスリリース動画Editorial Notes:The Apprentice の参加者になった気分です (脇)大学の自治を守るのは大変重要ですが、ファカルティは大学側の政府への抗議をどう受け取ってるんでしょう。しかし、9 billionだったり2.2 billionだったり、桁が大き過ぎてもうよくわからなくなってきました(萩)
This podcast episode features experts Paolo Strati, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, Gloria Iacoboni,... The post Sequencing therapies in R/R NHL: immunotherapy in DLBCL, BTKis in MCL, & more! appeared first on VJHemOnc.
TikTok Flat Earthers; News Items: De-extincting the Dire Wolf, What Experts Think About AI, Planned Obsolescence, VR Touch Sensory; Who's That Noisy; Your Questions and E-mails: SNPs vs Sequencing; Science or Fiction
Dan & Billy welcome back longtime friend & Nostalgia Test Podcast Allstar Jeremy Madson to put Metallica's 90s MTV Era to the ultimate test—THE NOSTALGIA TEST! “We're on the reverse trajectory of Kiss. Right? Because KISS took the makeup off in the nineties and Metallic put it on.” -Jeremy Madson The boys continue the Metallica Eras journey Nostalgia Test Podcast Metalheads with the controversial 90s studio albums The Black Album, Load, & Reload, also known as the MTV era & the Jason Newstead. Dan, Billy, & Jeremy headbang down memory lane and talk about hearing these albums for the first time, the weird transition from the thrash era to whatever this mid-life metal crisis was, the shift in Metallica's musical style, the peculiar cover art for Load & Reload, and production choices. They go track-by-track and create a 10-track merged version of Load & Reload called Unload, which you can listen to here. In the end, the guys rank the 90s era albums. If you're a Metallica nerd, this episode is for you. If you're not, listen anyway and give it 5-stars. Listen to Unload on Spotify! Email us (thenostalgiatest@gmail.com) ranking so we can share them on the next Metallica episode! APPROXIMATE RUN OF SHOW: 00:00 Introduction to the Metallica Nostalgia Test 00:37 Recap of Previous Episodes and Albums 01:17 The Nineties Era: MTV and Jason Newstead 01:55 Metallica's Costume Era and Music Videos 03:23 High School Memories and Metallica's Influence 09:26 The Black Album: A Turning Point 19:24 Load and Reload: The Controversial Albums 40:51 Guitar Solos and Bob Rock's Influence 41:58 Debating the Merits of 'Bleeding Me' 42:34 Critiquing 'Cure' and Other Tracks 44:24 Discussing 'Wasting My Hate' 46:38 Country Influences in Metallica's Music 47:11 The Controversial 'Mama Said' 47:46 Evaluating 'Thorn Within' and 'Ronnie' 50:42 The Outlaw Torn and Album Reflection 51:10 Nostalgia Test: Does 'Load' Hold Up? 55:50 Comparing 'Load' to Other Albums of the Era 58:13 Introduction to 'Reload' and Its Reception 58:48 Lead Singles and Album Strategy 01:00:35 Track-by-Track Breakdown of 'Reload' 01:09:32 The Unforgiven II: A Sequel Song 01:13:29 Mixed Reviews on 'Better Than You' and 'Slither' 01:14:56 Debating the Middle Part of the Song 01:15:25 Critiquing the Lyrics and Vocals 01:15:49 Generic Hard Rock and Stoner Rock Comparisons 01:16:39 Discussing 'Where the Wild Things Are' 01:17:05 Lars' Dad's Brutal Honesty 01:17:44 Evaluating 'Prince Charming' 01:18:07 The Unmemorable Riffs 01:20:33 The Irish Bar Drinking Song Vibe 01:21:20 WWE and 'Attitude' 01:21:27 The Lengthy 'Fixer' 01:23:01 Reload Exhaustion and Nostalgia 01:29:50 Ranking and Sequencing the Best Tracks 01:43:45 Final Thoughts and Ranking the Era Contact/Book The Nostalgia Test Podcast! If you had a great time listening to The Nostalgia Test Podcast and want to book us on your next podcast or have perform at your themed party, or have us host a special event, fill out the form below and LET'S GET NOSTALGIC! We can do so many fun Nostalgic Events! Podcast Guest Appearances Themed Parties Hosting Screenings Corporate Events Reunions Weddings Birthday Parties Trivia The Nostalgia Test Podcast will create a personalized Nostalgic experience for any occasion! Email us at thenostalgiatest@gmail.com or fill out the Google Form below to get the process started. We're open to in-person and virtual events. Pricing may vary depending on the details of your event/party. LET'S GET NOSTALGIC! Keep up with all things The Nostalgia Test Podcast on Instagram | Substack | Discord | TikTok | Bluesky | YouTube | Facebook The intro and outro music ('Neon Attack 80s') is by Emanmusic. The Lithology Brewing ad music ("Red, White, Black, & Blue") is by PEG and the Rejected
Welcome to another episode of the Oncology Brothers podcast! In this episode, Drs. Rohit and Rahul Gosain are joined by Dr. Aman Chauhan, a medical oncologist specializing in neuroendocrine tumors from Sylvester Comprehensive Cancer Center in Miami. As of April 2025, the oncology landscape has seen 10 new FDA approvals, including the recent approval of cabozantinib for neuroendocrine tumors based on the CABINET study. The discussion dived deep into the implications of this approval, the study design, and how cabozantinib fits into the treatment landscape for both pancreatic and extra-pancreatic neuroendocrine tumors. Key topics covered in this episode include: • The evolution of treatment options for neuroendocrine tumors • Insights into the CABINET study design and results • Sequencing treatment options for patients with neuroendocrine tumors • Side effects and management strategies for cabozantinib • The importance of personalized treatment approaches in oncology Join us as we explore the exciting advancements in neuroendocrine tumor management and what they mean for patients and oncologists alike. Don't forget to like, subscribe, and check out our other discussions on FDA approvals, toxicity management, and conference highlights! Follow us on social media: • X/Twitter: https://twitter.com/oncbrothers • Instagram: https://www.instagram.com/oncbrothers • Website: https://oncbrothers.com/ Don't forget to like, subscribe, and hit the notification bell for more updates on oncology insights!
Sequencing with the #1 Virtual Reality Hitting Tool
Send us a textBRAND NEW BOOK - The Daily Bible Devotional Volume 2 (Acts - Ephesians) is now available on Amazon. We hope this becomes a great daily tool in engaging with the New Testament, one chapter at a time. Amazon - (paperback, hardcover, and Kindle)Sponsors: Jon Cunningham, Owner, Cunningham Financial GroupWebsite: www.cunninghamfinancialgroup.com Phone: 205-326-7364Tyler Cain, Senior Loan Officer, Statewide MortgageWebsites: https://statewidemortgage.com/https://tylercain.floify.com/Phone: 813-380-8487Here's the Exercise of the Episode:Answer four questions:- Why are you a Christian?- Why do you go to worship?- Why do you treat everyone with kindness?- Why do you abstain from sexual immorality?First - Answer each question starting with JESUSSecond - Answer each starting with OTHERSFinally - Answer each starting with YOURSELFThis is the way to process and prioritize all we do.Sequencing is Important: J.O.Y.
Welcome to the CavasShips Podcast with Christopher P. Cavas and Chris Servello…a weekly podcast looking at naval and maritime events and issues of the day – in the US, across the seas and around the world. This week…keeping the Navy's fighting ships in fighting trim is all about sequencing the maintenance correctly. Robb Chadwick, a retired flag officer with extensive at sea experience explains how thoughtful sequencing of maintenance can make all the difference in saving time and money. Please send us feedback by DM'ing @CavasShips or @CSSProvision or you can email chriscavas@gmail.com or cservello@defaeroreport.com.
What are the personalized medicine and market lessons from the fall of 23andMe? David W. Johnson and Julie Murchinson perform a postmortem on the failure of the direct-to-consumer genetic testing company on “Sequencing the Fallout from the 23andMe Collapse,” the new episode of the 4sight Health Roundup podcast, moderated by David Burda. Listen.
This episode of Don't Miss a Beat, recorded at the American College of Cardiology (ACC) 2025 Annual Scientific Sessions, explores the evolving landscape of heart failure with preserved ejection fraction (HFpEF) treatment, focusing on the implementation of combination therapies. Hosts Steve Greene, MD, and Muthiah Vaduganathan, MD, MPH, discuss the transition from a previously limited treatment landscape to a new era with multiple proven therapeutic options. To open the episode, Greene argues in favor of rapid-sequence implementation of HFpEF therapies, drawing parallels to the established 4-pillar guideline-directed medical therapy (GDMT) for heart failure with reduced ejection fraction (HFrEF). He highlights 3 key classes of medications—SGLT2 inhibitors, non-steroidal mineralocorticoid receptor antagonists (MRAs), and incretin-based therapies—as the foundation of HFpEF treatment. He emphasizes the importance of early and aggressive therapy initiation to maximize clinical benefits and reduce the risk of delayed or missed treatment opportunities among this population. Vaduganathan acknowledges the strength of the data supporting combination therapy but suggests a more risk-based approach, considering the broad clinical variability among HFpEF patients. He advocates for prioritizing rapid implementation in high-risk patients, such as those recently hospitalized, while allowing a more measured approach for lower-risk individuals. The discussion also touches on the role of phenotyping in tailoring treatment decisions, with GLP-1 receptor agonists being particularly relevant for patients with obesity and ARNi potentially benefiting those with mildly reduced ejection fraction. Looking ahead, the hosts preview upcoming trials, including CONFIDENCE and CONFIRMATION, which will evaluate combination therapy strategies in chronic kidney disease and HFpEF populations. They also discuss the potential of fixed-dose combination therapies to simplify implementation and improve adherence. The episode closes with both experts agreeing on the need for a structured, evidence-based approach to HFpEF treatment while emphasizing the importance of translating trial data into real-world practice. Relevant disclosures for Vaduganathan include Amgen, AstraZeneca, Bayer AG, Boehringer Ingelheim Pharmaceuticals, Cytokinetics, Lexicon, and others. Relevant disclosures for Greene include Amgen, AstraZeneca, Bayer Healthcare Pharmaceuticals, Boehringer Ingelheim Pharmaceuticals, Cytokinetics, and others. Chapters 00:00-Intro 02:30-Argument for Rapid Sequencing 05:32-Argument Against Rapid Sequencing 10:00-Argument for Risk-Based Sequencing 14:25-Pillars of GDMT in HFpEF
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/CPE/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/PZK865. CME/MOC/NCPD/CPE/AAPA/IPCE credit will be available until March 26, 2026.ALK+ mNSCLC Care Compass: Taking Your Best Shot First—Selecting and Sequencing Targeted Therapy and Teaming Up to Achieve Long-Term Success In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and LUNGevity Foundation. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Pfizer.Disclosure information is available at the beginning of the video presentation.
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/CPE/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/PZK865. CME/MOC/NCPD/CPE/AAPA/IPCE credit will be available until March 26, 2026.ALK+ mNSCLC Care Compass: Taking Your Best Shot First—Selecting and Sequencing Targeted Therapy and Teaming Up to Achieve Long-Term Success In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and LUNGevity Foundation. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Pfizer.Disclosure information is available at the beginning of the video presentation.
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/CPE/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/PZK865. CME/MOC/NCPD/CPE/AAPA/IPCE credit will be available until March 26, 2026.ALK+ mNSCLC Care Compass: Taking Your Best Shot First—Selecting and Sequencing Targeted Therapy and Teaming Up to Achieve Long-Term Success In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and LUNGevity Foundation. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Pfizer.Disclosure information is available at the beginning of the video presentation.
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/CPE/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/PZK865. CME/MOC/NCPD/CPE/AAPA/IPCE credit will be available until March 26, 2026.ALK+ mNSCLC Care Compass: Taking Your Best Shot First—Selecting and Sequencing Targeted Therapy and Teaming Up to Achieve Long-Term Success In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and LUNGevity Foundation. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Pfizer.Disclosure information is available at the beginning of the video presentation.
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/CPE/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/PZK865. CME/MOC/NCPD/CPE/AAPA/IPCE credit will be available until March 26, 2026.ALK+ mNSCLC Care Compass: Taking Your Best Shot First—Selecting and Sequencing Targeted Therapy and Teaming Up to Achieve Long-Term Success In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and LUNGevity Foundation. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Pfizer.Disclosure information is available at the beginning of the video presentation.
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/CPE/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/PZK865. CME/MOC/NCPD/CPE/AAPA/IPCE credit will be available until March 26, 2026.ALK+ mNSCLC Care Compass: Taking Your Best Shot First—Selecting and Sequencing Targeted Therapy and Teaming Up to Achieve Long-Term Success In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and LUNGevity Foundation. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Pfizer.Disclosure information is available at the beginning of the video presentation.
Michael Reinking joins Diane King Hall at the NYSE set to discuss this week's volatility ahead of April 2nd. With tariff deadlines looming and investors positioning for market swings, Michael sees flows moving from high growth names into energy, materials, staples and healthcare. Looking forward, Michael says tariff impact will be a major theme for the upcoming earnings season.======== Schwab Network ========Empowering every investor and trader, every market day.Subscribe to the Market Minute newsletter - https://schwabnetwork.com/subscribeDownload the iOS app - https://apps.apple.com/us/app/schwab-network/id1460719185Download the Amazon Fire Tv App - https://www.amazon.com/TD-Ameritrade-Network/dp/B07KRD76C7Watch on Sling - https://watch.sling.com/1/asset/191928615bd8d47686f94682aefaa007/watchWatch on Vizio - https://www.vizio.com/en/watchfreeplus-exploreWatch on DistroTV - https://www.distro.tv/live/schwab-network/Follow us on X – / schwabnetwork Follow us on Facebook – / schwabnetwork Follow us on LinkedIn - / schwab-network About Schwab Network - https://schwabnetwork.com/about
CME credits: 1.00 Valid until: 21-11-2026 Claim your CME credit at https://reachmd.com/programs/cme/DefiningtheStandardofCareandOptimalSequencinginBRAFMutantmCRcSecondLineandBeyond/32944/ In this series, Dr. Fortunato Ciardiello and Dr. Jenny Seligmann review the management of metastatic colorectal cancer (mCRC), with a focus on timing and methodology of molecular testing, targeted treatment combinations for BRAF-mutant mCRC, the management of treatment-related adverse events.
Josh Bowen is the founder of Astria, the easiest way to deploy decentralized rollups. Why you should listen In this conversation, Josh Bowen, co-founder of Astria, discusses the evolution and significance of decentralized sequencing in the blockchain ecosystem. He shares insights on the current state of rollups, the impact of regulatory changes, and the future of decentralized finance (DeFi). Josh also introduces Astria's new rollup, Flame, and emphasizes the importance of user experience in attracting wider adoption of DeFi. The discussion touches on the existential questions surrounding decentralization and the future of blockchain technology. Astria is building the shared sequencing layer for modular blockchains — an innovative approach designed to supercharge rollup scalability while preserving decentralization. By decoupling sequencing from execution, Astria gives developers the ability to launch fast, censorship-resistant rollups without needing to bootstrap their own validator sets or trusted sequencers. The core idea? Shared sequencing as a public good — one decentralized sequencer network serving many rollups. Under the hood, Astria's shared sequencer is powered by CometBFT and integrated with Celestia for data availability. This enables near-instant transaction inclusion and atomic cross-rollup composability, solving some of the most pressing coordination problems in the modular stack. Developers can spin up an Astria-integrated rollup with tools like Rollkit and benefit from out-of-the-box speed, fairness, and security. In a world of rollup proliferation, Astria is carving out the infrastructure to make modular chains truly interoperable and decentralized. Supporting links Stabull Finance Astria Andy on Twitter Brave New Coin on Twitter Brave New Coin If you enjoyed the show please subscribe to the Crypto Conversation and give us a 5-star rating and a positive review in whatever podcast app you are using.
Triple Negative Breast Cancer CancerCare Connect Education Workshops
- Overview of Breast Cancer in Younger Women, Including Diagnosing, Staging & ER, PR, HER2 Status - Unique Issues for Younger Women Living with Breast Cancer - Precision Medicine & Sequencing of Treatment - Genetic Testing, Including BRCA Testing - What Informs Treatment Decisions & Options - Understanding Your Pathology Report - Updates on Clinical Trials: How Research Increases Treatment Options - Tools that Help Indicate What Types of Treatment Are Indicated: Surgery, Chemotherapy & Radiation Treatments - Questions to Ask Your Health Care Team - Managing Side Effects, Symptoms, Discomfort & Pain - Quality-of-Life, Including Sexual Health, Pregnancy & Fertility Issues - Practical & Emotional Coping Tips - Questions for Our Panel of Experts
- Overview of Breast Cancer in Younger Women, Including Diagnosing, Staging & ER, PR, HER2 Status - Unique Issues for Younger Women Living with Breast Cancer - Precision Medicine & Sequencing of Treatment - Genetic Testing, Including BRCA Testing - What Informs Treatment Decisions & Options - Understanding Your Pathology Report - Updates on Clinical Trials: How Research Increases Treatment Options - Tools that Help Indicate What Types of Treatment Are Indicated: Surgery, Chemotherapy & Radiation Treatments - Questions to Ask Your Health Care Team - Managing Side Effects, Symptoms, Discomfort & Pain - Quality-of-Life, Including Sexual Health, Pregnancy & Fertility Issues - Practical & Emotional Coping Tips - Questions for Our Panel of Experts
Metastatic Breast Cancer CancerCare Connect Education Workshops
- Overview of Breast Cancer in Younger Women, Including Diagnosing, Staging & ER, PR, HER2 Status - Unique Issues for Younger Women Living with Breast Cancer - Precision Medicine & Sequencing of Treatment - Genetic Testing, Including BRCA Testing - What Informs Treatment Decisions & Options - Understanding Your Pathology Report - Updates on Clinical Trials: How Research Increases Treatment Options - Tools that Help Indicate What Types of Treatment Are Indicated: Surgery, Chemotherapy & Radiation Treatments - Questions to Ask Your Health Care Team - Managing Side Effects, Symptoms, Discomfort & Pain - Quality-of-Life, Including Sexual Health, Pregnancy & Fertility Issues - Practical & Emotional Coping Tips - Questions for Our Panel of Experts
- Overview of Breast Cancer in Younger Women, Including Diagnosing, Staging & ER, PR, HER2 Status - Unique Issues for Younger Women Living with Breast Cancer - Precision Medicine & Sequencing of Treatment - Genetic Testing, Including BRCA Testing - What Informs Treatment Decisions & Options - Understanding Your Pathology Report - Updates on Clinical Trials: How Research Increases Treatment Options - Tools that Help Indicate What Types of Treatment Are Indicated: Surgery, Chemotherapy & Radiation Treatments - Questions to Ask Your Health Care Team - Managing Side Effects, Symptoms, Discomfort & Pain - Quality-of-Life, Including Sexual Health, Pregnancy & Fertility Issues - Practical & Emotional Coping Tips - Questions for Our Panel of Experts
Success isn't about tackling every problem at once—it's about mastering the art of sequencing and managing your schedule. Learn how to prioritize effectively, focus on what truly matters, and create a sustainable routine for long-term success.---If you want to level up, text me at 725-527-7783! Get access to our real estate community, coaching, courses, and events at Wealthy University https://www.wealthyuniversity.com/Join our FREE community, weekly calls, and bible studies for Christian entrepreneurs and business people. https://www.wealthykingdom.com/--- ---About Ryan Pineda: Ryan Pineda has been in the real estate industry since 2010 and has invested in over $100,000,000 of real estate. He has completed over 700 flips and wholesales, and he owns over 650 rental units. As an entrepreneur, he has founded seven different businesses that have generated 7-8 figures of revenue. Ryan has amassed over 2 million followers on social media a...
In our new series Insights, go inside Class 6 of NEXT PM. In this short segment, Taylor will highlight the importance of work sequencing - the critical role of dependency mapping as well as potential bottlenecks to be aware of. Enjoy the Insights and #BeNEXT.To learn more about NEXT PM, please visit our website at www.nextleadershipacademy.org/pm
In the same way that genome sequencing determines the genetic makeup of an organism, Bryan Johnson — the investor and founder behind the Don't Die movement – wants to start “foodome” sequencing. Learn more about your ad choices. Visit podcastchoices.com/adchoices
View all cards mentioned in this episodeAndy, Anthony, and Zach talk about improving as a Magic player, building a community and how they try to balance the two. They talk about the challenges of fostering positive social standards and how that can conflict with trying to improve at a competitive game.Discussed in this episode:The Null HypothesisCheck us out on Twitch and YouTube for paper Cube gameplay.You can find the hosts' Cubes on Cube Cobra:Andy's “Bun Magic” CubeAnthony's “Regular” CubeYou can find both your hosts in the MTG Cube Talk Discord. Send in questions to the show at mail@luckypaper.co or our p.o. box:Lucky PaperPO Box 4855Baltimore, MD 21211If you'd like to show your support for the show, please leave us a review on iTunes or wherever you listen.Musical production by DJ James Nasty.Timestamps0:00 - Intro2:22 - Balancing Developing Skill as a Player with Building a Community9:17 - The Nuanced, Complex Social Dynamics of Playing Magic12:57 - The Factors that Contribute to a Playgroup's Vibe27:20 - The Tension Between Improvement and Community32:54 - The Value of Shared Expectations in a Community40:45 - On “Take Backs” and Learning from Your Mistakes1:03:07 - Zach asks Andy and Anthony if they're satisfied with their level of competitiveness1:06:42 - Sequencing speed round
duckDNA recently concluded its second season, which brought continued enthusiasm from hunters and several never-before-seen hybrids! On this episode, Dr. Mike Brasher is joined by conservation science assistants, Kayci Messerly and Katie Tucker, and Dr. Phil Lavretsky to share initial results from season 2 while discussing genetic mysteries uncovered through the analysis of several unique hybrid ducks. Also discussed are behind-the-scenes interactions with participating hunters and the potential future of duckDNA. Thanks to hunters for their support and participation and a special thanks to our year 2 funding partners -- Pinola Conservancy, Rice Pond Preserve, and Brian Hornung.Listen now: www.ducks.org/DUPodcastSend feedback: DUPodcast@ducks.org
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/NCPD/CPE/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/ZPG865. CME/NCPD/CPE/AAPA/IPCE credit will be available until March 2, 2026.Fine-Tuning the Selection and Sequencing of HER2-Targeting Therapies in HER2-Positive MBC With and Without CNS Metastases: Expert Guidance on How to Individualize Therapy Based on Latest Evidence, Disease Features, Treatment Characteristics, and Patient Needs and Preferences In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and GRASP. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Pfizer.Disclosure information is available at the beginning of the video presentation.
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/NCPD/CPE/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/ZPG865. CME/NCPD/CPE/AAPA/IPCE credit will be available until March 2, 2026.Fine-Tuning the Selection and Sequencing of HER2-Targeting Therapies in HER2-Positive MBC With and Without CNS Metastases: Expert Guidance on How to Individualize Therapy Based on Latest Evidence, Disease Features, Treatment Characteristics, and Patient Needs and Preferences In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and GRASP. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Pfizer.Disclosure information is available at the beginning of the video presentation.
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/NCPD/CPE/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/ZPG865. CME/NCPD/CPE/AAPA/IPCE credit will be available until March 2, 2026.Fine-Tuning the Selection and Sequencing of HER2-Targeting Therapies in HER2-Positive MBC With and Without CNS Metastases: Expert Guidance on How to Individualize Therapy Based on Latest Evidence, Disease Features, Treatment Characteristics, and Patient Needs and Preferences In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and GRASP. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Pfizer.Disclosure information is available at the beginning of the video presentation.
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/NCPD/CPE/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/ZPG865. CME/NCPD/CPE/AAPA/IPCE credit will be available until March 2, 2026.Fine-Tuning the Selection and Sequencing of HER2-Targeting Therapies in HER2-Positive MBC With and Without CNS Metastases: Expert Guidance on How to Individualize Therapy Based on Latest Evidence, Disease Features, Treatment Characteristics, and Patient Needs and Preferences In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and GRASP. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Pfizer.Disclosure information is available at the beginning of the video presentation.
Dr. Stuart McGill (IG: @backfitpro, X: @drstuartmcgill, FB: @Backfitpro, YT: @backfitpro9992) is a ‘distinguished professor emeritus', University of Waterloo, where he was a professor for 32 years. His laboratory and experimental research clinic investigated issues related to the causal mechanisms of back pain, how to rehabilitate back-pained people and enhance both injury resilience and performance. His advice is often sought by golfers, trainers, therapists and others from around the world. His work has produced over 245-peer reviewed scientific journal papers, several textbooks, and many international awards and he has mentored over 37 graduate students during his scientific journey. He continues as the Chief Scientific Officer for Backfitpro, Inc. Difficult back cases, and elite performers, are regularly referred to him for consultation. Be sure to check out Dr. McGill's books: ‘Back Mechanic' CLICK HERE ‘Gift of Injury' CLICK HERE Also be sure to watch Dr. McGill's video: ‘The New Science of Golf' featuring Dr. McGill and WLD Champion Lee Brandon CLICK HERE. ‘Back Mechanic Book w/ Video Streaming models CLICK HERE You can learn more about Dr. McGill's work and view more of his books and videos on his website: www.backfitpro.com Dr. McGill has also offered our listeners a 10% discount on all purchases, so be sure to use code BFPGOLF360 at checkout. Affiliates: PAYNTR Golf Shoes - Payntr Golf delivers performance traction resulting from our shoe's ability to resist, support, & enhance – allowing golfers the capacity to leverage ground forces, control movement, and maximize speed at impact. https://payntrgolf.com/golf360 Books by Rande Somma Why Do We Call Them Leaders?: https://amzn.to/3VIhDI6 Leadersh!t: https://amzn.to/3VY4zib The Stack System is the ultimate device to use when looking to biohack your swing speed. Co-developed by ‘The Savant of Speed' – Dr. Sasho MacKenzie, and PING engineer Marty Jertsen, it is a device that every golfer can utilize to increase their swing speed. The Stack System uses AI to ensure that your development is as efficient as possible. To order The Stack you can do so on their website at www.thestacksystem.com. Be sure to use the discount code GOLF360 to receive your special discount. Sponsors: Get your 15% discount on your next order of JustThrive Probiotic at https://justthrivehealth.com/ (use code: GOLF360) Looking to play one of the best golf courses in the Hilton Head Island area? Be sure to check out Old South Golf Links and have one of your best golf experiences ever https://www.oldsouthgolf.com/
I'm joined by Christian Henry, CEO of PacBio, a company leading the way in high-accuracy long-read sequencing. We break down what that means in simple terms, how this technology is helping families solve their diagnostic odyssey, and why some genetic tests miss key information that PacBio can detect. Plus, if you've already had whole genome sequencing without finding an answer, Christian explains why it might be time to take another look. We also dive into the future of genetic testing, what needs to change for sequencing to become a routine part of medical care, and how families and advocates can help drive progress forward. This episode is all about hope, science, and the relentless pursuit of answers. Happy Rare Disease Day, and thank you for being part of this incredible community! Topics Covered: ✅ What is long-read sequencing, and how is it different from traditional genetic testing? ✅ How PacBio's technology is solving rare disease mysteries faster and more accurately. ✅ Why some families don't get answers from whole genome sequencing—and why they should consider trying again. ✅ The biggest barriers to making genetic testing more accessible and routine in rare disease care. ✅ How long-read sequencing could help lead to future treatments, not just diagnoses. ✅ What the next five years of genomic sequencing could look like. ✅ How rare disease families and advocacy groups can collaborate with PacBio to accelerate discoveries. Resources & Links:
Featuring slide presentations and related discussion from Prof Martin Hutchings, Dr Manali Kamdar, Dr Matthew Lunning and Prof Gilles Salles, including the following topics: Evolving Role of Chimeric Antigen Receptor (CAR) T-Cell Therapy in Diffuse Large B-Cell Lymphoma (DLBCL) — Dr Kamdar (0:00) Case: A 61-year-old man with Stage IV non-GCB DLBCL receives R-CHOP but experiences disease progression 8 months later (30:39) Case: A 68-year-old man with double-hit DLBCL who experiences disease progression on chemotherapy and second-line CAR T-cell therapy receives glofitamab (39:22) Incorporation of Bispecific Antibody Therapy into DLBCL Management — Prof Hutchings (45:25) Case: A 42-year-old man with progressive DLBCL refractory to 2 lines of therapy receives glofitamab with a durable response (1:07:30) Case: An 81-year-old woman with multiregimen-refractory DLBCL experiences a prolonged response to epcoritamab (1:14:25) Case: A 69-year-old man with follicular lymphoma transformed to DLBCL and refractory to 3 lines of treatment receives glofitamab (1:21:48) Selection and Sequencing of Other Available Therapies for Relapsed/Refractory (R/R) DLBCL — Prof Salles (1:24:37) Case: An 82-year-old woman with follicular lymphoma transformed to DLBCL receives tafasitamab/lenalidomide (1:42:05) Case: A 69-year-old man with urinary bladder carcinoma and recurrent GCB DLBCL receives loncastuximab tesirine (1:46:26) Promising Investigational Approaches for Patients with R/R DLBCL — Dr Lunning (2:00:37) Case: An 80-year-old woman with multiregimen-refractory GCB DLBCL seeks treatment requiring minimal clinic visits and receives loncastuximab tesirine (2:15:59) Case: A 54-year-old man with primary refractory non-GCB DLBCL receives CAR T-cell therapy, and follow-up imaging on day 29 demonstrates a Deauville score of 4 (2:25:22) CME information and select publications
Going Pro Yoga (Formerly the Yoga Teacher Evolution Podcast)
What if the best approach to health wasn't about choosing between Eastern and Western medicine, but embracing both? This episode explores how these two medical philosophies complement each other—Eastern medicine focuses on prevention, balance, and holistic well-being, while Western medicine excels in emergency care, diagnostics, and treating acute conditions. The discussion highlights how integrating both perspectives can lead to a more comprehensive and empowered approach to personal health.Michael shares real-life examples, including a woman who avoided Western intervention and tragically passed away after her appendix ruptured. They emphasize that while Eastern medicine provides powerful preventative practices like acupuncture, Ayurveda, and herbal remedies, there are times when Western treatments are essential for survival. The conversation also explores the evolving acceptance of holistic healing practices, as yoga, meditation, and herbal medicine become increasingly recognized for their benefits.The episode encourages listeners to take responsibility for their health by tuning into their bodies, using preventative self-care, and remaining open to both scientific and traditional healing methods. By blending modern medicine with ancient wisdom, individuals can create a personalized, integrative approach to long-term wellness.Episode Chapters:00:00:00 - Integrating Eastern and Western Medicine00:02:36 - Balancing Eastern and Western Medicine00:05:07 - Integrating Eastern and Western Medicine00:07:28 - Integrating Eastern and Western Medicine00:10:49 - The Strengths and Limitations of Western and Eastern Medicine00:12:43 - Integrating Eastern and Western Approaches to Medicine00:16:45 - Balancing Eastern and Western Approaches to Healing00:19:51 - Balancing Eastern and Western Approaches to Wellness00:22:32 - Balancing the Body Through Preventative Care and Herbal Medicine00:25:37 - Dealing with Unexpected Stomach Pain00:28:24 - Integrating Eastern and Western Approaches for Holistic Health00:31:18 - Blending Eastern and Western Medicine00:34:02 - Exploring Yoga Interests and Connections—-------—-------—-Michael Henri's Instagram:https://www.instagram.com/michaelyoga.pt/ Going Pro Yoga's Instagram: https://www.instagram/com/goingproyoga/—-------—-------—-Other Mentions:Book: Encyclopedia of Herbal Medicine---About Going Pro Yoga:At Going Pro Yoga, we help yoga teachers become even better by teaching them new skills and giving them the tools they need to make their yoga classes safe, fun, and special for everyone.**Right now you can try Going Pro Yoga FREE for 7-days and sample: All Tools Needed to Master Cueing, Sequencing, and Alignment Video Library of over 75 fully Sequenced Classes, Sequence Chunks, and Flows FIRST EVER Yoga Cueing System with Over 160 poses and Hundreds of Variations Wisdom Talks from over 20,000 Hours of Teaching Experience Anatomy and Injury Prevention as it relates to Yoga.To Learn More, Visit Going Pro Yoga, andStart your 7-Day Free Trial!For more information about in-person trainings in Bali,https://www.elementsofpoweryoga.com/advancedtrainings
- Overview of Cervical Cancer, Including Diagnosis & Staging - Combination Treatments - How Precision Medicine & Testing Inform Your Treatment Decisions - New & Emerging Treatment Approaches - The Role of the Pathologist - Biomarkers, Diagnostic Technologies, Sequencing of Treatments - Updates on Clinical Trials - How Research Increases Treatment Options - Nutrition & Hydration Tips & Suggestions - Questions for Our Panel of Experts
Featuring perspectives from Dr Anthony El-Khoueiry, Dr Richard S Finn, Dr Aiwu Ruth He and Dr Stacey Stein, moderated by Dr Stephen “Fred” Divers, including the following topics: Adjuvant Systemic Therapy for Early-Stage Hepatocellular Carcinoma (HCC) — Dr El-Khoueiry Introduction (0:00) Faculty Presentation (3:08) IMbrave050: Adjuvant systemic treatment for high-risk resected HCC — Robin K (Katie) Kelley, MD and Thomas A Abrams, MD (13:43) Neoadjuvant systemic therapy for patients with borderline resectable HCC — Dr Abrams (20:15) Case: A man in his early 70s with locally advanced HCC and tumor thrombus that extends into the right atrium — Ghassan Abou-Alfa, MD, MBA (24:34) Recent Developments in the Management of Intermediate-Stage HCC — Dr Finn Faculty Presentation (31:18) EMERALD-1 and LEAP-012 trials of TACE with immunotherapy — Drs Abrams and Kelley (42:15) Systemic treatment for patients with Child-Pugh B cirrhosis and HCC — Dr Kelley (48:29) Use of immunotherapy for patients with autoimmune disorders: A man in his early 30s with active colitis and metastatic HCC receives first-line lenvatinib — Drs Abrams and Abou-Alfa (53:05) Current First-Line Therapy for Advanced HCC — Dr He Faculty Presentation (1:00:39) Selection of first-line treatment regimen for advanced HCC — Drs Abrams, Kelley and Abou-Alfa (1:12:00) Role of single-agent immunotherapy in the treatment of advanced HCC — Dr Kelley (1:18:22) Management of HCC in patients with discordant tumor markers or mixed tumor histology — Dr Abrams (1:23:03) Promising Investigational Front-Line Strategies for Advanced HCC; Selection and Sequencing of Therapy for Relapsed/Refractory HCC — Dr Stein Faculty Presentation (1:29:42) Choice of tyrosine kinase inhibitor as second-line systemic treatment for HCC; prevention, monitoring and mitigation of lenvatinib-associated side effects — Dr Kelley (1:42:59) Case: A man in his early 70s with metastatic HCC that has rapidly progressed on atezolizumab/bevacizumab — Dr Abou-Alfa (1:49:27) Supportive care measures to manage ascites in patients with HCC — Dr Abrams (1:55:20) CME information and select publications
Baby-making is more complicated than it might seem, and any couple struggling to conceive and achieve a successful pregnancy is faced with a confusing maze of fertility optimization measures.This is where whole genome personal genotyping can be very helpful. Your genes obviously have everything to do with fertility, and your genes are unique. Personal genotyping can illuminate what you might be doing wrong in the fertility optimization department. It empowers you and your partner to practice precision Biohacking by identifying the medicine, supplements, therapies, and lifestyle changes you need to bring a beautiful baby into the world.This deep-dive presentation will elucidate 17 problematic fertility genes you may have, how to find them, which conditions they are associated with, and give you a jumping-off point for addressing them...2:45 Important disclaimer: your genes don't have to be your destiny4:00 How to search your genome8:11 Single gene disorders10:18 On procrastination12:57 Polygenetic complexes17:22 MTHFR21:38 SLC19A122:04 DHFR23:25 MTR and MTT26:30 TCN27:00 PAI/SERPINE131:37 PEMT32:38 APEO34:18 FVL and F235:30 NOS37:05 GST/GPX42:04 PON43:20 VDR44:50 Male factor infertility51:40 Stress management hacks57:55 Folic Acid - The New Smoking?59:25 Niacin/Vitamin B31:00:30 Acupuncture1:04:50 Conclusion and inspirationRead: Decode Your Genome with Personal Genotyping for Precision Fertility Optimization
This week on The Genetics Podcast, Patrick is joined by Jonathon Hill, associate professor at Brigham Young University and co-founder and VP of Wasatch Biolabs. Jonathan and Patrick discuss the power of long-read sequencing, how Wasatch Biolabs was created, and how Jonathon has fostered valuable collaborations between academic labs and Wasatch Biolabs.
Among patients with colorectal cancer and synchronous liver metastases, the subgroup with a primary cancer in the rectum is especially challenging. Compared with colon cancer, most patients with stage IV rectal cancer will have locally advanced primary tumors at increased risk for obstructive and/or post-operative complications resulting in delays in systemic therapy. In this episode from the HPB team at Behind the Knife, listen in on the discussion about treatment sequencing for synchronous liver metastasis from rectal cancer Hosts Anish J. Jain MD (@anishjayjain) is a current PGY3 General Surgery Resident at Stanford University and a former T32 Research Fellow at the University of Texas MD Anderson Cancer Center. Timothy E. Newhook MD, FACS (@timnewhook19) is an Assistant Professor within the Department of Surgical Oncology. He is also the associate program director of the HPB fellowship at the University of Texas MD Anderson Cancer Center. Jean-Nicolas Vauthey MD, FACS (@VautheyMD) is Professor of Surgery and Chief of the HPB Section, as well as the Dallas/Fort Worth Living Legend Chair of Cancer Research in the Department of Surgical Oncology at The University of Texas MD Anderson Cancer Center. Learning Objectives · Develop an understanding of the three treatment sequences for resection of disease in patients with synchronous liver metastasis from a primary rectal cancer (reverse, combined, and classic approach) · Develop an understanding of the benefits, risks, and nuances of each of the three treatment sequences · Develop an understanding of which patient cases each treatment sequence is ideal for as well as which cases they are not suitable for. Papers Referenced (in the order they were mentioned in the episode): 1) Conrad C, Vauthey JN, Masayuki O, et al. Individualized Treatment Sequencing Selection Contributes to Optimized Survival in Patients with Rectal Cancer and Synchronous Liver Metastases. Ann Surg Oncol. 2017 Dec;24(13):3857-3864. https://pubmed.ncbi.nlm.nih.gov/28929463/ 2) Maki H, Ayabe RI, Nishioka Y, et al. Hepatectomy Before Primary Tumor Resection as Preferred Approach for Synchronous Liver Metastases from Rectal Cancer. Ann Surg Oncol. 2023 Sep;30(9):5390-5400. doi: 10.1245/s10434-023-13656-4. Epub 2023 Jun 7. Erratum in: Ann Surg Oncol. 2023 Sep;30(9):5405. https://pubmed.ncbi.nlm.nih.gov/37285096/ Additional Suggested Reading Mentha G, Majno PE, Andres A, Rubbia-Brandt L, Morel P, Roth AD. Neoadjuvant chemotherapy and resection of advanced synchronous liver metastases before treatment of the colorectal primary. Br J Surg. 2006 Jul;93(7):872-8. https://pubmed.ncbi.nlm.nih.gov/16671066/ Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more. If you liked this episode, check out our recent episodes here: https://app.behindtheknife.org/listen
I know many of you have been waiting for my annual Pranayama Yoga Teacher Training and I'm very excited to share that the wait is finally over. As you're listening to this episode, all the details are live and the waitlist is open.To get a first-hand experience of what it's like inside this course, I looked at one of our older Pranayama podcast episodes that I wanted to share with you. I want to allow you to practice a little Pranayama with me via this podcast. So what I'm sharing with you today is called Breathe into the New Year: A Mini Pranayama Class and Sequencing Guide.Pranayama Episode Highlights:Defining the word ‘pranayama'Parts of respirationNadi Shodhana, the king of breath practiceWhy it's not meant to be rushedStage 1: Preparatory practiceNasikagra MudraGuided self-practice for stage oneStage 2: Equalizing the breathGuided self-practice for stage twoHow we tend to force our breath outStage 3: Antara KumbhakaGuided self-practice for stage threeRecap of the three stages of the practicePranayama Yoga Teacher TrainingPranayama Yoga Teacher Training Info SessionJoin our mailing listFind all the resources mentioned in this episodeConnect with us on Instagram
Featuring perspectives from Dr Erika Hamilton, Dr Kevin Kalinsky, Dr Ian E Krop, Dr Joyce O'Shaughnessy and Dr Sara M Tolaney, including the following topics: Introduction (0:00) Optimizing the Care of Patients with HER2-Positive Metastatic Breast Cancer (mBC) — Dr Krop (10:17) Selection and Sequencing of Therapy for Patients with Metastatic Triple-Negative Breast Cancer — Dr Tolaney (37:54) Integrating Novel Agents and Approaches into the Management of Endocrine-Resistant Hormone Receptor-Positive mBC — Dr Kalinsky (53:59) Tolerability Considerations with Approved and Investigational Antibody-Drug Conjugates — Dr O'Shaughnessy (1:14:16) Other Important Care Considerations for Patients with mBC — Dr Hamilton (1:41:30) CME information and select publications
In this episode of the Epigenetics Podcast, we talked with Vijay Ramani from the Gladstone Institute to talk about his work on Single-Molecule Adenine Methylated Oligonucleosome Sequencing Assay (SAMOSA). Our discussion starts with Vijay Ramani's impactful contributions to the field during his time in Jay Shendure's lab, where he worked on several innovative methods, including RNA proximity ligation. This project was conceived during his graduate studies, aiming to adapt techniques from DNA research to investigate RNA structures—a largely unexplored area at the time. We delved into the nuances of his experiences in graduate school, emphasizing how critical it was to have mentors who provided room for creativity and autonomy in experimental design. Dr. Ramani then shares insights about his foray into developing more refined methodologies, such as in-situ DNA Hi-C, a revolutionary protocol tailored for three-dimensional genomic mapping. He explained the rationale behind his projects, comparing the outcomes with contemporaneous advancements in methods like Micro-C. The discussion highlighted the importance of understanding enzyme bias in chromatin studies and the need for meticulous experimental design to ensure the validity of biological interpretations. We further explored exciting advancements in single-cell genomics, specifically Ramani's work on developing sci-Hi-C. This innovative technique leverages combinatorial indexing to allow high-resolution mapping of chromatin architecture at the single-cell level, a significant leap forward in understanding the complexities of gene regulation. As we progress, Ramani detailed his transition from graduate student to independent investigator starting his own lab. He elaborated on the challenges and excitements associated with establishing his research focus in chromatin structure and function using advanced sequencing technologies. Employing various strategies, including the innovative SAMOSA assay, his research seeks to elucidate the mechanisms by which chromatin structure influences transcriptional regulation. We also discussed the heterogeneity of chromatin and its implications for gene expression. Ramani provided a fascinating perspective on how variations in chromatin structure could affect gene activity, highlighting potential avenues for future research that aims to untangle the complex dynamics at play in both healthy and diseased states. References Ramani, V., Cusanovich, D., Hause, R. et al. Mapping 3D genome architecture through in situ DNase Hi-C. Nat Protoc 11, 2104–2121 (2016). https://doi.org/10.1038/nprot.2016.126 Nour J Abdulhay, Colin P McNally, Laura J Hsieh, Sivakanthan Kasinathan, Aidan Keith, Laurel S Estes, Mehran Karimzadeh, Jason G Underwood, Hani Goodarzi, Geeta J Narlikar, Vijay Ramani (2020) Massively multiplex single-molecule oligonucleosome footprinting eLife 9:e59404. https://doi.org/10.7554/eLife.59404 Abdulhay, N.J., Hsieh, L.J., McNally, C.P. et al. Nucleosome density shapes kilobase-scale regulation by a mammalian chromatin remodeler. Nat Struct Mol Biol 30, 1571–1581 (2023). https://doi.org/10.1038/s41594-023-01093-6 Nanda, A.S., Wu, K., Irkliyenko, I. et al. Direct transposition of native DNA for sensitive multimodal single-molecule sequencing. Nat Genet 56, 1300–1309 (2024). https://doi.org/10.1038/s41588-024-01748-0 Related Episodes Epigenetic Mechanisms in Genome Regulation and Developmental Programming (James Hackett) Chromatin Profiling: From ChIP to CUT&RUN, CUT&Tag and CUTAC (Steven Henikoff) Split-Pool Recognition of Interactions by Tag Extension (SPRITE) (Mitch Guttman) Contact Epigenetics Podcast on X Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Epigenetics Podcast on Threads Active Motif on X Active Motif on LinkedIn Email: podcast@activemotif.com
Sequencing Of Agents CME Available: auau.auanet.org/node/41735 ACKNOWLEDGEMENTS: Support provided by independent educational grants from: Lantheus Medical Imaging Novartis Pharmaceuticals Corporation LEARNING OBJECTIVES: At the conclusion of this activity, participants will be able to: 1. Review the latest evidence and clinical guidelines that inform the sequencing of therapeutic agents in metastatic prostate cancer, including data from key clinical trials. 3. Implement strategies for managing and overcoming resistance to therapy in metastatic prostate cancer, considering the role of sequencing in delaying resistance. 4. Apply best practices for monitoring treatment response and disease progression in patients undergoing therapy, and adjust sequencing strategies based on these observations.
A new year brings new questions and more insights to the topic of Highly Pathogenic Avian Influenza. Dr. Mike Brasher is joined by leading experts in the field of avian influenza, Dr. Dave Stallknecht, Dr. Richard Webby, and Dr. Jennifer Ballard to discuss the current status of avian influenza, what we've learned since 2022, and what we still don't understand. Recent changes have been noted in the genetic code of the circulating virus, but what does this mean for the risk it poses to birds, mammals, and humans? How do we study these changes? What waterfowl species are most affected, and do we understand why these effects differ among species? Also discussed is recent science about risks to hunting dogs, what hunters need to do if they observe sick or dead birds, why hunters should be vigilant about being tested for avian flu if they feel ill, and how we can all work to reduce the likelihood of the virus becoming more severe. Tune in for an information-packed episode that is of growing relevance to everyone.Listen now: www.ducks.org/DUPodcastSend feedback: DUPodcast@ducks.org
The Theriome team, represented by Alex Mohr and Micah Lowe, delves into the transformative advancements in metabolomic testing, uncovering how these innovations provide actionable insights into the microbiome's functionality and its critical role in health and wellness. They emphasize the importance of resilience within the microbiome, the impact of dietary choices, and the challenges posed by current trends in nutrition. Alex Mohr introduces forward-thinking concepts like digital twinning and intuitive health reports, demonstrating how these tools can streamline health interventions and empower personalized care. Micah Lowe highlights the potential of metagenomics to deepen our understanding of microbiome dynamics and guide more effective health strategies. Together, they explore the future of precision medicine through multi-omics integration, advocating for a holistic approach to health that prioritizes actionable insights and long-term resilience. This discussion underscores the need for innovative testing solutions to revolutionize how we understand and improve gut health.Highlights00:00 Introduction to Theriome and Team Background05:49 Current State of Microbiome Testing11:57 Functional Insights from Microbiome Profiling17:57 Resilience in the Microbiome24:06 Challenges with Current Dietary Trends33:09 Interpreting Health Reports39:18 Understanding Resilience in Health51:12 The Future of Health Testing56:28 Integrating Multi-Omics for Precision MedicineGet Theriome: https://therio.meCode: beautifullybrokenUPGRADE YOUR WELLNESSSaga Bands: https://ca.saga.fitness/?ref=titvyccmCode: beautifullybrokenStemRegen: https://www.stemregen.co/products/stemregen?_ef_transaction_id=&oid=1&affid=52Code: beautifullybrokenLightPathLED https://lightpathled.pxf.io/c/3438432/2059835/25794Code: beautifullybrokenSilver Biotics Wound Healing Gel: https://bit.ly/3JnxyDDCode: BEAUTIFULLYBROKEN CONNECT WITH FREDDIE Check out my website and store: (http://www.beautifullybroken.world) Instagram: (https://www.instagram.com/beautifullybroken.world/) YouTube: (https://www.youtube.com/@BeautifullyBrokenWorld)
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