POPULARITY
A Obiettivo Salute risveglio parliamo di un 'fuoco' che non scalda, ma brucia: il Fuoco di Sant’Antonio, noto anche come Herpes Zoster. Una malattia che può colpire in età adulta e che, grazie alla prevenzione, possiamo tenere lontana. Ne parliamo con la prof.ssa Antonella Castagna, Ordinario di Malattie Infettive dell’IRCCS Ospedale San Raffaele e Direttore della scuola di Specializzazione in Malattie Infettive e Tropicali presso l’Università Vita-Salute San Raffaele. Con l’esperta focus su cos'è l'Herpes Zoster, quali sono i sintomi e come prevenirlo.
Neste episódio do GeriPills, partimos de um caso clínico comum no consultório para discutir uma evidência que vem ganhando força: a vacinação contra o herpes zoster pode reduzir o risco de demência em idosos. Será que já podemos considerar essa vacina como parte das estratégias de prevenção cognitiva? Como isso se aplica na prática clínica? E o que dizem as diretrizes mais recentes? Um papo direto, prático e baseado em evidência, do jeito que o geriatra gosta. Ouça agora e saiba como incorporar mais essa ferramenta no seu plano de cuidado com o idoso. Assine o GeriUpdates https://www.gericlass.com.br/op/geriupdates/
On episode #78 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 3/27/25 – 4/9/25. Hosts: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, RSS, email Become a patron of Puscast! Links for this episode Viral Demise of the Milwaukee protocol for rabies (CID) A natural experiment on the effect of herpes zoster vaccination on dementia (Nature) Taking a shot at dementia(microbeTV: TWiV) Recommendations from the 10th European Conference on Infections in Leukaemia for the management of cytomegalovirusin patients after allogeneic haematopoietic cell transplantation and other T-cell-engaging therapies (LANCET: Infectious Diseases) Epstein-Barr virus exposure precedes Crohn`s disease development (Gastroenterology aga) Bacterial Blujepa (gepotidacin) approved by US FDA for treatment of uncomplicated urinary tract infections (uUTIs) in female adults and paediatric patients 12 years of age and older (GSK) GSK wins FDA nod for first oral UTI antibiotic in almost 30 years(BioSpace) Efficacy and safety of individualised versus standard 10-day antibiotic treatment in children with febrile urinary tract infection (INDI-UTI): a pragmatic, open-label, multicentre, randomised, controlled, non-inferiority trial in Denmark (LANCET: Infectious Diseases) Frequency and severity of Myasthenia Gravis exacerbations associated with the use of ciprofloxacin, levofloxacin, and azithromycin (Muscle & Nerve) The cost of blood cultures: a barrier to diagnosis in low-income and middle-income countries (LANCET: Microbe) Rethinking blood culture (LANCET: Microbe) Trends in Anaplasmosis Over the Past Decade: A Review of Clinical Features, Laboratory Data and Outcomes(CID) Fungal The Last of US Season 2 (YouTube) Cracks in the curriculum: the hidden deficiencies in fungal disease coverage in medical books (OFID) Kazachstania slooffiae fungemia: a case report and literature review on an emerging opportunistic pathogen in humans (OFID) Plasma microbial cell-free DNS metagenomic sequencing for diagnosis of invasive fungal diseases among high risk outpatient and inpatient immunocompromised hosts (CID) Parasitic Fatal Case of Splash Pad–Associated Naegleria fowleri Meningoencephalitis — Pulaski County, Arkansas, September 2023 (CDC: MMWR) Notes from the Field: Fatal Acanthamoeba Encephalitis in a patient who regularly used tap water in an electronic nasal irrigation device and a continuous positive airway pressure machine at home — new Mexico, 2023 (CDC: MMWR) Malaria (NEJM) Miscellaneous FDA grants marketing authorization of first home test for chlamydia, gonorrhea and trichomoniasis (FDA) Music is by Ronald Jenkees Information on this podcast should not be considered as medical advice.
Winkelheide, Martin www.deutschlandfunk.de, Sprechstunde
How many measles cases in 2025? Is there a blood test for Alzheimer's? Is the shingles vaccine safe? Does the shingles vaccine prevent dementia? AMA's Vice President of Science, Medicine and Public Health, Andrea Garcia, JD, MPH, covers measles outbreak news, a new blood test for Alzheimer's disease, the latest trends in childhood vaccination rates, and how the shingles vaccine helps prevent dementia. American Medical Association CXO Todd Unger hosts.
Westerhaus, Christine www.deutschlandfunk.de, Forschung aktuell
En este episodio hablaremos del virus del Herpes Zóster, también conocido como culebrilla, de la mano de la Dra. Gloria Huerta, infectóloga, pediatra y maestra en ciencias médicas, quien nos explica qué es, cuáles son sus síntomas, cómo obtener un diagnóstico adecuado y su relación con la varicela. Además, hablaremos los tratamientos disponibles y, lo más importante, cómo protegernos a través de la prevención y las vacunas. Sigue a Hablando en Plata en hablandoenplata.mx y la Dra. Huerta @gloriahuerta Learn more about your ad choices. Visit megaphone.fm/adchoices
Virus, ki v otroštvu povzroči norice, lahko pozneje v življenju ponovno izbruhne. V odraslem obdobju se – ob stresu ali padcu odpornosti – lahko pojavi v obliki kožnih mehurčkov, ki jih spremlja pekoča bolečina. Kako prepoznamo pasovca oz. herpes zoster in kakšne so najnovejše smernice pri zdravljenju omenjenega obolenja, bo v četrtkovem Svetovalnem servisu razložila prof. dr. Mojca Matičič, dr. med. s Klinike za infekcijske bolezni in vročinska stanja UKC Ljubljana. Pišite na prvi@rtvslo.si ali pokličite med oddajo!
ROMA (ITALPRESS) - In questa edizione:- Contro il virus sinciziale un nuovo vaccino a mRNA - Herpes zoster e RSV, esperti a confronto su vaccini e prevenzione- Farmaceutica, customer experience sempre più centrale- Calamità, la Sicilia potenzia il suo modulo sanitario d'emergenza sat/col/gtr
PALERMO (ITALPRESS) - Puntare sulla vaccinazione per prevenire e contrastare patologie emergenti come il Virus respiratorio sinciziale o l'Herpes zoster, comunemente noto come il fuoco di Sant'Antonio: è uno dei principali messaggi che arriva da Palermo, in occasione del 57° Congresso Nazionale della Società Italiana di Igiene, Medicina preventiva e Sanità Pubblica. col/xd8/fsc/sat/gtr
PALERMO (ITALPRESS) - Puntare sulla vaccinazione per prevenire e contrastare patologie emergenti come il Virus respiratorio sinciziale o l'Herpes zoster, comunemente noto come il fuoco di Sant'Antonio: è uno dei principali messaggi che arriva da Palermo, in occasione del 57° Congresso Nazionale della Società Italiana di Igiene, Medicina preventiva e Sanità Pubblica. col/xd8/fsc/sat/gtr
PALERMO (ITALPRESS) - Puntare sulla vaccinazione per prevenire e contrastare patologie emergenti come il Virus respiratorio sinciziale o l'Herpes zoster, comunemente noto come il fuoco di Sant'Antonio: è uno dei principali messaggi che arriva da Palermo, in occasione del 57° Congresso Nazionale della Società Italiana di Igiene, Medicina preventiva e Sanità Pubblica. col/xd8/fsc/sat/gtr
In this Healthed lecture, Paul Griffin focuses on herpes zoster immunisation, its effectiveness and limitations, and the challenges associated with getting this older population, now eligible for the vaccine, optimally protected.See omnystudio.com/listener for privacy information.
Shingles can be a challenging condition, particularly for individuals with compromised immune systems. In this episode, Susan Johnson discusses Traditional Chinese Medicine techniques, such as acupuncture, seven-star hammering, and herbal approaches, sharing insights on how these methods may be used to support overall well-being. Tune in to learn more!To access the full written article, click here. And don't forget to subscribe to our podcast on your favorite podcast provider, so you never miss an episode!See our Monthly Practitioner Discounts https://www.mayway.com/monthly-specialsSign up for the Mayway Newsletterhttps://www.mayway.com/newsletter-signupFollow ushttps://www.facebook.com/MaywayHerbs/https://www.instagram.com/maywayherbs/
Grunderkrankungen als Risikofaktor für Herpes zoster: Erfahrungen aus der Praxis Asthma, Diabetes, Niereninsuffizienz, rheumatoide Arthritis und eine Reihe weiterer Erkrankungen können das Risiko an Gürtelrose zu erkranken erhöhen, betonte der Allgemeinmediziner Prof. Jörg Schelling, Martinsried, in der Podcast-Serie „O-Ton Allgemeinmedizin Extra“. Auch zunehmendes Alter, starke berufliche und private Belastungen (z.B. die Pflege von Angehörigen) oder eine Depression können die Immunabwehr beeinträchtigen und eine Gürtelrose begünstigen. Es komme deshalb darauf an, immer den gesamten Patienten/die gesamte Patientin zu sehen und das Risiko abzuschätzen. Die Impfung schützt Den besten Schutz vor Herpes zoster bietet eine Impfung. Die STIKO empfiehlt sie für Menschen ab 50 Jahre, wenn eine chronische Grunderkrankung wie z.B. Diabetes vorliegt, für alle anderen ab 60 Jahre. Bei den Impfquoten ist Schelling zufolge noch viel Luft nach oben. Er rät deshalb bei der Impfberatung authentisch zu sein und mit gutem Beispiel voranzugehen. Diese Episode ist mit freundlicher Unterstützung von GSK entstanden. Zum Folgen-Überblick: medical-tribune.de/o-ton-allgemeinmedizin
In this episode, we review the high-yield topic of Herpes Zoster (Shingles) from the Heme section. Follow Medbullets on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets Linkedin: https://www.linkedin.com/company/medbullets
Rachael Niederer answers some of the common questions surrounding Herpes Zoster Ophthalmicus(HZO), also known as shingles.
In this episode, Dr. Cremers reviews the difference between Herpes Zoster (Shingles) and Herpes Simplex Infections and discusses symptoms, diagnosis, treatment, and how it can affect the eyes.
Can a nasal spray treat anaphylaxis? Find out about this and more in today's PeerDirect Medical News Podcast.
In der neuesten Folge unseres Podcasts geht es um das Thema Gürtelrose. Herpes Zoster, auch unter dem Begriff Gürtelrose bekannt, wird durch das Varizella-Zoster-Virus ausgelöst, das bei Erstkontakt, meist im Kindesalter, Varizellen (Windpocken) verursacht. Nach Abklingen der Varizellen verbleibt das Virus lebenslang in den Nervenzellen und kann zu einem späteren Zeitpunkt als Herpes Zoster wieder auftreten (sog. Virus-Reaktivierung). Typisch für Herpes Zoster ist zunächst ein brennender Schmerz, gefolgt von einer zumeist halbseitigen, bandartigen Ausbreitung von Bläschen in dem zum betroffenen Nerv gehörenden Hautareal. Am häufigsten treten die Symptome an Rumpf und Brustkorb auf, aber sie kommen auch im Bereich des Kopfes vor. Nach Abheilen des Hautausschlages kann ein Nervenschmerz (sog. Post-Zoster Neuralgie) in der vormals betroffenen Hautregion noch mehrere Monate bis Jahre anhalten. Wie ansteckend ist die Krankheit? Welche Symptome gibt es? Wie läuft die Behandlung? Gibt es Risikogruppen und für wen ist die Gürtelrose-Impfung überhaupt sinnvoll? Dies und vieles mehr wird in der neuen Folge des Krebs Podcasts besprochen. Referenten: Prof. Dr. med. Dr. h.c. Sehouli (Direktor der Klinik für Gynäkologie mit Zentrum für onkologische Chirurgie (CVK) und Klinik für Gynäkologie (CBF), Charité Berlin) Dr. med. Robert Armbrust (Oberarzt, Klinik für Gynäkologie mit Zentrum für onkologische Chirurgie, Charité Berlin) Frau Dr. Anton (Allgemeinmedizinerin, Charité Berlin) Diese Folge des Krebspodcast wird unterstützt von GSK. GSK ist jedoch nicht für den Inhalt des Vortrags verantwortlich. Thema und Inhalt obliegen der wissenschaftlichen Freiheit der Referenten. Weitere Informationen unter: https://de.gsk.com/de-de/ Freigabenummer: NP-DE-HZU-AUDI-240006, 07/24 Mehr unter: www.krebs-podcast.de
In der neuesten Folge unseres Podcasts geht es um das Thema Gürtelrose.Herpes Zoster, auch unter dem Begriff Gürtelrose bekannt, wird durch das Varizella-Zoster-Virus ausgelöst, das bei Erstkontakt, meist im Kindesalter, Varizellen (Windpocken) verursacht. Nach Abklingen der Varizellen verbleibt das Virus lebenslang in den Nervenzellen und kann zu einem späteren Zeitpunkt als Herpes Zoster wieder auftreten (sog. Virus-Reaktivierung).Typisch für Herpes Zoster ist zunächst ein brennender Schmerz, gefolgt von einer zumeist halbseitigen, bandartigen Ausbreitung von Bläschen in dem zum betroffenen Nerv gehörenden Hautareal. Am häufigsten treten die Symptome an Rumpf und Brustkorb auf, aber sie kommen auch im Bereich des Kopfes vor. Nach Abheilen des Hautausschlages kann ein Nervenschmerz (sog. Post-Zoster Neuralgie) in der vormals betroffenen Hautregion noch mehrere Monate bis Jahre anhalten.Wie ansteckend ist die Krankheit? Welche Symptome gibt es? Wie läuft die Behandlung? Gibt es Risikogruppen und für wen ist die Gürtelrose-Impfung überhaupt sinnvoll? Dies und vieles mehr wird in der neuen Folge des Krebs Podcasts besprochen.Referenten:Prof. Dr. med. Dr. h.c. Sehouli (Direktor der Klinik für Gynäkologie mit Zentrum für onkologische Chirurgie (CVK) und Klinik für Gynäkologie (CBF), Charité Berlin)Dr. med. Robert Armbrust (Oberarzt, Klinik für Gynäkologie mit Zentrum für onkologische Chirurgie, Charité Berlin)Frau Dr. Anton (Allgemeinmedizinerin, Charité Berlin)Diese Folge des Krebspodcast wird unterstützt von GSK. GSK ist jedoch nicht für den Inhalt des Vortrags verantwortlich. Thema und Inhalt obliegen der wissenschaftlichen Freiheit der Referenten.Weitere Informationen unter: https://de.gsk.com/de-de/Freigabenummer: NP-DE-HZU-AUDI-240006, 07/24Mehr unter: www.krebs-podcast.de Hosted on Acast. See acast.com/privacy for more information.
Über das Thema „Impfen im ÖGD – was kann die Impfprävention“ diskutiert Dr. Sybille Somogyi in der neuen Ausgabe ihrer Podcast-Reihe „Wissenschaft trifft Praxis“. Unsere Referentin für Infektionsschutz und Hygiene spricht dabei mit ihren Gästen unter anderem über die Frage, wie wichtig regionale Impfkampagnen sind und dabei helfen, eine sachgerechte Impfaufklärung zu betreiben.Die Gäste der Podcast-Folge beschäftigen sich schon lange intensiv mit dem aktuellen Thema:Dr. med. Katharina Hüppe, Stellv. Vorsitzende des Bundesverband Ärztinnen/Ärzte des Öffentlichen Gesundheitsdienstes, stellt die aktuellen STIKO-Empfehlungen vor und erläutert viele wichtige Neuerungen, wie die Impfempfehlung für Säuglinge gegen Meningokokken der Serogruppe B sowie die Standardimpfung gegen Sars-Cov-2 und gegen Herpes Zoster. Dr. med. Martin Oldenburg, Leiter der Abteilung Gesundheitsvorsorge im Ministerium für Justiz und Gesundheit Schleswig-Holstein erläutert, dass regionale Impfkampagnen ein wichtiger Hebel zur Impfaufklärung sind und die Gesundheitsämter viel stärker darin unterstützt werden müssten, selbst Impfungen durchzuführen.Wir wünschen Ihnen viel Spaß & Erkenntnis beim Zuhören.Weitere LinksEmpfehlungen der Ständigen Impfkommission: https://www.rki.de/DE/Content/Kommissionen/STIKO/Empfehlungen/Impfempfehlungen_node.htmlImpfkalender (Standardimpfungen) für Säuglinge, Kinder, Jugendliche und Erwachsene; 2024. https://www.rki.de/DE/Content/Kommissionen/STIKO/Empfehlungen/Aktuelles/Impfkalender.pdf?__blob=publicationFileNationale Lenkungsgruppe Impfen (NaLI). https://www.nali-impfen.de/nali/Impfkampagne in Schleswig-Holstein – die Partner. https://www.schleswig-holstein.de/DE/landesregierung/themen/gesundheit-verbraucherschutz/impfen/Service/_documents/SH-Impfkampagne-diePartner.htmlDr. med. Katharina Hüppe auf LinkedINDr. med. Martin Oldenburg auf LinkedINDie Website der Akademie für Öffentliches GesundheitswesenDie ÖGD-NEWS-App der AkademieAbonnieren Sie unseren NewsletterDer Akademie-Podcast „Wissenschaft trifft Praxis“ erscheint im Wechsel mit dem zweiten regelmäßigen Akademie-Podcast „Akademie-Journal“ Mehr Podcasts und Publikationen der Akademie finden Sie in unserer Mediathek. Wir freuen uns auf Ihr Feedback an: redaktion@akademie-oegw.de
O Herpes Zoster é uma doença causada pela reativação do vírus varicela-zoster, o mesmo da catapora. Ele pode permanecer no organismo por toda a vida. O Herpes Zoster provoca lesões no corpo com o aparecimento de bolhas vermelhas na pele. Saiba mais no episódio.See omnystudio.com/listener for privacy information.
Consultório do Rádio Livre: Hoje a gente fala sobre herpes zoster e o aumento do número de internações causadas pela doença no Brasil.
Dr. Jonathan Kay discusses abstracts POS0620 and OP0020 presented at Eular 2024 in Vienna, Austria.
Dr. Jonathan Kay discusses abstracts POS0620 and OP0020 presented at Eular 2024 in Vienna, Austria.
The effect of pantoprazole on eGFR slope, antiviral medications for Herpes Zoster, & link between pediatric AKI in Uzbekistan and cough syrups are covered in this episode of ASN Kidney Translation: An ASN Journals' Podcast.
Using common case scenarios, Robert H. Hopkins, Jr., MD, MACP, and Laura P. Hurley, MD, MPH, discuss strategies for optimizing shingles vaccine uptake, including:The pathophysiology of shingles to better understand risk and burdenCDC guidelines and ACIP shingles vaccine recommendations, including considerations for those who are immunocompromised Strategies for optimizing shingles vaccine uptake no matter the clinical settingHow to address shingles vaccine‒related adverse events Addressing insurance-related concerns Presenters:Robert H. Hopkins, Jr., MD, MACPProfessor of Internal Medicine and PediatricsChief, Division of General Internal MedicineUniversity of Arkansas for Medical SciencesSchool of MedicineLittle Rock, ArkansasLaura P. Hurley, MD, MPHGeneral Internist and Health Services ResearcherAssociate Professor of MedicineDepartment of General Internal MedicineUniversity of Colorado Anschutz Medical CampusAurora, ColoradoLink to downloadable slides:https://bit.ly/4aWn6jhLink to full program:https://bit.ly/4aWBiJ0Get access to all of our new podcasts by subscribing to the CCO Infectious Disease Podcast on Apple Podcasts, Google Podcasts, or Spotify.
In the second of his two part series, Dr. John Toney reviews additional infectious syndromes involving the eye. For Part 2, Dr. Toney begins by discussing uveitis, and then covers preseptal and postseptal orbital cellulitis. Next he shares information on endogenous endophthalmitis and dacrocystitis. Finally, in a lightning round, trachoma, Parinaud’s oculoglandular syndrome, and Herpes Zoster ophthalmicus are presented. For Part I of this talk, please see the previous week’s posted presentation.
One of the updated Cochrane Reviews from October 2023 is the third update of a review of the effects of vaccines for Herpes Zoster. It was conducted by a team of researchers in Brazil and we asked one of the authors, Juliana Gomes from the Department of Geriatrics and Gerontology at the Federal University of São Paulo, to describe its importance and main findings.
One of the updated Cochrane Reviews from October 2023 is the third update of a review of the effects of vaccines for Herpes Zoster. It was conducted by a team of researchers in Brazil and we asked one of the authors, Juliana Gomes from the Department of Geriatrics and Gerontology at the Federal University of São Paulo, to describe its importance and main findings.
From November 1, 2023 the Federal Government provides vaccines to eligible communities through the National Immunization Program. - Mulai 1 November 2023 Pemerintah Federal menyediakan vaksin bagi masyarakat yang memenuhi syarat melalui Program Imunisasi Nasional.
The pain from shingles has been described as aching, burning, stabbing or shock-like. It's painful, comes with a number of complications and is extremely common. - Rasa sakit akibat herpes zoster digambarkan sebagai rasa sakit terbakar, menusuk, atau seperti syok. Ini menyakitkan, disertai sejumlah komplikasi dan sangat umum terjadi.
Mye man kan vaksinere mot, men som forsikring flest må man være ute FØR "ulykken", for at det skal være noe poeng.
Jaume Segalés habla con los responsables de Mundo Natural de salud y de Herpes Zoster.
Amyotrophic lateral sclerosis, MultipleSclerosis and Lyme Disease are they one and the same? Is ALS and MS sometimes caused by caused by the Herpes Zoster Virus? In this episode will discuss the possibilities that these life taking diseases may all be related and treatable in a safe though unconventional way.
Amyotrophic lateral sclerosis, MultipleSclerosis and Lyme Disease are they one and the same? Is ALS and MS sometimes caused by caused by the Herpes Zoster Virus? In this episode will discuss the possibilities that these life taking diseases may all be related and treatable in a safe though unconventional way.
Amyotrophic lateral sclerosis, MultipleSclerosis and Lyme Disease are they one and the same? Is ALS and MS sometimes caused by caused by the Herpes Zoster Virus? In this episode will discuss the possibilities that these life taking diseases may all be related and treatable in a safe though unconventional way.
Join Professors Iain McInnes, Laura Coates, and Peter Nash as they discuss the latest top research in PsA. The first paper we will discuss aimed to systematically review the incidence of HZ among RA, PsA, AS and UC patients treated with either TOFA, BARI or UPA. The second paper then goes on to describe the methodology being undertaken in the ground-breaking Phase 3b APEX study, which seeks to further assess the effects of guselkumab Q4W and Q8W on PsA outcomes.
Einen Herpes Zoster erkennt man oft auf den ersten Blick. Deutlich schwieriger gestaltet sich hingegen das Schmerzmanagement, besonders bei älteren und komorbiden Erkrankten. Der Allgemeinmediziner Prof. Dr. Jörg Schelling spricht in dieser Folge über die therapeutischen Herausforderungen bei Herpes Zoster und erklärt, warum rechtzeitiges Impfen von Risikogruppen – über und unter 60 Jahren – so wichtig ist.
Kristin is joined by Dr Emma Goeman and Dr Jean Li-Kim-Moy to discuss the ins and outs of herpes zoster (more commonly known as shingles).
Amyotrophic lateral sclerosis, MultipleSclerosis and Lyme Disease are they one and the same? Is ALS and MS sometimes caused by caused by the Herpes Zoster Virus? In this episode will discuss the possibilities that these life taking diseases may all be related and treatable in a safe though unconventional way.
Amyotrophic lateral sclerosis, MultipleSclerosis and Lyme Disease are they one and the same? Is ALS and MS sometimes caused by caused by the Herpes Zoster Virus? In this episode will discuss the possibilities that these life taking diseases may all be related and treatable in a safe though unconventional way.
Amyotrophic lateral sclerosis, MultipleSclerosis and Lyme Disease are they one and the same? Is ALS and MS sometimes caused by caused by the Herpes Zoster Virus? In this episode will discuss the possibilities that these life taking diseases may all be related and treatable in a safe though unconventional way.
Amyotrophic lateral sclerosis, MultipleSclerosis and Lyme Disease are they one and the same? Is ALS and MS sometimes caused by caused by the Herpes Zoster Virus? In this episode will discuss the possibilities that these life taking diseases may all be related and treatable in a safe though unconventional way.
Episode 109: Shingles vaccine before 50 Prabhjot and Dr. Arreaza discuss the indications and contraindications of the zoster recombinant vaccine (Shingrix®). Shingrix is now FDA-approved to be used in people younger than 50 years old. Magic mushroom as a therapy for alcohol use disorder. Introduction: “Magic mushroom” as a potential treatment for alcohol addiction By Hector Arreaza, MD. Addiction is one of the biggest challenges in medicine. Patients with addictions are at risk of adverse events or even death from overdose but also are at risk of withdrawal when trying to quit. As medical providers, our goal is to assist our patients to stop using substances that may be toxic and cause detrimental effects on their health in the short and long term. It is not easy to help patients overcome the discomfort, cravings, and even life-threatening symptoms that result from withdrawal. Out of the many addictions, alcohol use disorder is one of the most destructive addictions, and the harms from it go beyond the personal effects, as it affects families, communities, and the whole nation. It is a serious public health issue. It is estimated that 15 million people (12 and older) in the US have alcohol use disorder, and about 140,000 people die every year from alcohol-related causes. Many patients would like to stop drinking, but the withdrawal symptoms may be more than just discomfort and may become unbearable and even fatal. Today I want to share the news published on August 24, 2022, on JAMA and many news outlets regarding the potential use of Psylocibin as an adjunct therapy to quit drinking alcohol. This was a double-blind randomized clinical trial that compared Psylocibin with diphenhydramine. Psilocybin is also known as “magic mushroom”. Participants were offered 12 weeks of psychotherapy and were randomly assigned to receive psilocybin vs. diphenhydramine during 2-day-long medication sessions at weeks 4 and 8. There were 93 participants. The percentage of heavy drinking days during a 32-week period after the first dose of medication was 9.7% for the psilocybin group and 23.6% for the diphenhydramine group. So, patients in the Psylocibin group had decreased heavy drinking, and the mean alcohol consumption was also lower. Blinding was an issue during the study because many participants could guess which medication they were receiving. Some participants described “flying over landscapes, seeing [their] late father and merging telepathically with historical figures.” The bottom line of the study is that administration of Psilocybin in combination with psychotherapy produced a significant reduction in the percentage of heavy drinking days over and above those produced by active placebo and psychotherapy. These are exciting news for those who are trying to quit alcohol, and it provides a foundation for additional research on psilocybin-assisted treatment for AUD. This is the Rio Bravo qWeek Podcast, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California. Our program is affiliated with UCLA, and it's sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. This podcast was created for educational purposes only. Visit your primary care provider for additional medical advice. ________________________________________________________________________________________________________________ Shingrix before 50. By Prabhjot Kaur, MS4, Ross University School of Medicine. 1. What is Shingrix? It's a recombinant zoster vaccine to protect against Herpes Zoster (Shingles) in adults over 50 years old. 2. What is Herpes Zoster? Prabhjot: It's a viral infection that is caused by the Varicella-Zoster virus, which also causes chickenpox. Chickenpox, also called varicella, can happen in children and adults. After a person is infected with chickenpox, the virus remains dormant in the dorsal root ganglia, which are the clusters of neurons along the spinal column. As the person grows older, or his or her immunity decreases due to conditions such as an infection, malignancy, or pregnancy, the dormant virus becomes reactivated. Prabhjot: When the virus reactivates in adults, it presents with a painful, blistering, itchy rash over the specific dermatomes. The rash mostly occurs on the torso, face, or upper extremities, and it is usually only on one side of the body. Arreaza: A common belief in the Latino culture (since our audience sees a lot of patients of Latino descent) is that if the rash crosses the midline of your body and it makes a circle around your chest, you will die. If you, as a doctor, get that question from a patient, the answer is: herpes zoster normally affects the root ganglia on one side of the body. If your patient has bilateral herpes zoster, you must rule out immunodeficiency. The rash may be preceded or followed by pain, burning, numbing, or tingling of the skin. Some patients might even have fevers, chills, fatigue, and photosensitivity. One of the most common complications of shingles is postherpetic neuralgia, which is a long-lasting pain after the blisters and rash have resolved. 3. What is the role of the vaccine? Prabhjot: Shingrix® can reduce the risk of shingles and its complications, such as postherpetic neuralgia. Shingrix is recommended for everyone over 50, even if they have already had shingles, received Zostavax® (discontinued in 2019), or received the varicella vaccine. Arreaza: Good point. Let´s talk a little bit about varicella in adults. Patients who have received the varicella vaccine as a child can still receive Shingrix. Let's remember the chickenpox vaccine (varicella vaccine) became available in the United States in 1995. Normally, a serology test for varicella is not required for people to receive the varicella vaccine as adults, except in certain patients who are planning immunosuppression in the near future. In such cases, if varicella immunity is not reactive, they should be vaccinated against varicella (live attenuated virus) if the immunosuppression can be delayed. Prabhjot: What if the patient is already immunosuppressed? Arreaza: If the patient is already immunosuppressed, the decision is not simple. The varicella vaccine is contraindicated, but some clinicians may recommend Shingrix for the potential protection against primary varicella. Post-exposure prophylaxis with antiviral therapy or immunoglobulin in case of exposure is possible. 4. How is Shingrix given? Prabhjot: Shingrix is given in 2 doses, and each dose is given 2-6 months apart. Its immunity stays strong for at least 7 years. Like most vaccines, the most common side effects of the Shingrix vaccine are redness, tenderness, swelling, and discomfort at the vaccine site. Shingrix is deemed to be safe for most people over 50 but not given to pregnant women, people with active shingles, and or with a severe allergy to the vaccine. Arreaza: Shingrix is generally avoided in patients with a known history of Guillain-Barré syndrome (GBS) due to a probable association between Shingrix and GBS. This association was not seen with Zostavax, so in case of history of GBS, Zostavax is an option. 5. Effectiveness. Prabhjot: As for its effectiveness, according to the CDC, Shingrix is 97% effective in preventing shingles in adults 50 to 69 and 91% in adults older than 70. If one is immunosuppressed and has a weakened immune system, the vaccine was effective, ranging between 69%-91% in preventing shingles. 6. New update: Prabhjot: New updates have been made to expand the vaccination of the population under 50 as well. On July 23, 2021, the FDA approved the vaccination for adults over the age of 18 who are at an increased risk or will be in the future due to immunodeficiency or immunosuppression. Such immunodeficiency could be secondary to a disease, malignancy, or therapy such as chemotherapy. Just like the prior recommendation, it is recommended for these individuals to receive two doses of Shingrix for the prevention of shingles and its complications. However, the interval between the two doses can be shortened from the recommended 2-6 months to 1-2 months if the person will be going through intense immunosuppression in the upcoming months. This shortened interval will prevent vaccination during an intense immunosuppressed state. The second dose must not be given before one month. 7. When to get vaccinated? Prabhjot: Ideally, one should get vaccinated before starting immunosuppressing therapy; if this cannot be possible, then one should aim for vaccination when their immune response is likely to be the strongest. For example, if it's an immunity-changing disease such as malignancy, the vaccine would be ideal in the beginning stages, and if a person will receive chemotherapy, it would be ideal to vaccinate before starting chemo. 8. Few recommendations from CDC: For Hematopoietic cell transplant: Administer Shingrix at least 3-12 months after transplantation. It is important to consider the vaccine is recommended 2 months before the prophylactic antiviral therapy is discontinued. Since the prophylactic antiviral therapy is also protecting against shingles, the vaccine is preferred to be injected while the antiviral therapy is going on. Arreaza: For allogeneic HCT (when donor is another person), Shingrix should be given a little bit later, 6-12 months after transplant, prior to discontinuation of antiviral therapy. Acyclovir, famciclovir, and valacyclovir will not neutralize the effectiveness of Shingrix because the vaccine is not a live virus vaccine. For cancers: It is ideal to administer Shingrix before chemo, immunosuppressive medications, radiation, or splenectomy. If that is not possible for some reason, administer the vaccine when the patient is stable and not acutely suppressed. For patients on long-term immunosuppressive therapies, administer the vaccine when the immune response is most likely the strongest or right before starting the next cycle of therapy. For patients with HIV: Prabhjot: Shingrix is recommended for patients with HIV due to the high risk of shingles. Immune response to the vaccine may be improved while the patient is on antiretroviral treatment. Bottom line: Shingrix is now recommended not only for those over 50 years old but also for those who are 18 and older and are immunosuppressed or will be on immunosuppressive therapy. This new change will benefit those who are receiving treatment and those who are awaiting treatment. Keep in mind to use the vaccine to prevent shingles and its complications. ________________________________________________________________________________________________________________ Conclusion: Now we conclude our episode number 109, “Shingles vaccine before 50.” We are used to giving Shingrix to patients older than 50, but we were reminded today that it is also indicated in patients older than 18 who are or will be immunosuppressed. Shingrix should be given in 2 doses 2-6 months apart. Your patients may not notice it, but by giving this vaccine, you are PREVENTING a painful rash that can have long-term effects. This week we thank Jennifer Thoene, Hector Arreaza, Prabhjot Kaur, and Arianna Lundquist. Audio edition by Adrianne Silva. Thanks for listening to Rio Bravo qWeek Podcast. If you have any feedback, contact us by email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week! ________________________________________________________________________________________________________________ References: Bogenschutz MP, Ross S, Bhatt S, et al. Percentage of Heavy Drinking Days Following Psilocybin-Assisted Psychotherapy vs Placebo in the Treatment of Adult Patients With Alcohol Use Disorder: A Randomized Clinical Trial. JAMA Psychiatry. Published online August 24, 2022. doi:10.1001/jamapsychiatry.2022.2096. https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2795625. Osborne, Margaret. Psychedelic ‘Magic Mushroom' Ingredient Could Help Treat Alcohol Addiction, Smart News, Smithsonian Magazine, https://www.smithsonianmag.com/smart-news/psychedelic-magic-mushroom-ingredient-could-help-treat-alcohol-addiction-180980658/ “Shingles Vaccination.” Centers for Disease Control and Prevention, page last reviewed: 24 May 2022, https://www.cdc.gov/vaccines/vpd/shingles/public/shingrix/index.html. “Clinical Considerations for Use of Recombinant Zoster Vaccine (RZV, Shingrix) in Immunocompromised Adults Aged ≥19 Years.” CDC.gov, 20 Jan. 2022. https://www.cdc.gov/shingles/vaccination/immunocompromised-adults.html. “Shingles.” Mayo Clinic, 17 Sept. 2021, https://www.mayoclinic.org/diseases-conditions/shingles/symptoms-causes/syc-20353054. Royalty-free music used for this episode: Salsa Trap by Caslo, downloaded on July, 20, 2022 from https://freemusicarchive.org/music/caslo/caslo-vol-1/salsa-trap/. Space Orbit by Scott Holmes, downloaded on July 20, 2022 from https://freemusicarchive.org/music/Scott_Holmes/.
This episode will take you through all the details about herpes zoster! We cover the approach, when you should take extra concern and refer to ophthalmology, and how to manage a whole spectrum of patients. Written by: Dr. Lauren Winquist (Internal Medicine Resident)Reviewed by: Dr. Megan Devlin (Infectious Diseases) and Dr. Rasha Abdul-Karim (General Internal Medicine)This episode was supported by Spatula Foods. Enjoy elevated cuisine every day with high-quality dishes you can cook yourself in just 10 minutes. Go to https://www.spatulafoods.com and use promo code INTERN for $40 off your first box- this will help support our podcast! Support the show
Take Home Points Classically, herpes zoster will present with rash and pain in a dermatomal distribution Immunocompromised patients are at greater risk for significant complications of zoster, including visceral dissemination and zoster ophthalmicus Appropriate therapy includes antiviral therapy within 72 hours of onset of symptoms and analgesia for acute neuritis Disseminated zoster and zoster ophthalmicus ... Read more The post REBEL Core Cast 78.0 – Herpes Zoster appeared first on REBEL EM - Emergency Medicine Blog.