Podcasts about Ras

Join Survivor Legend Jonny Fairplay, and Survivor Island of The Idols Janet Carbin as they breakdown Episode 2 of Survivor 51. We will be assessing all of the action from the episode and what we can expect from the Open Era! Stay tuned for all of our content this Survivor Season!Special thanks to our sponsor Big O Brand Skin care. Big O Brand has a special formula  of Ostrich Oil and is rich in Omega 3, 6, and 9! Bad strategy gets you voted out but bad skin care will leave you dry and your body dehydrated, Check out Big O Brand for all your skin care essentials and use PROMO CODE: Survivor at Checkout for 10% off! Tell them Fairplay sent you! https://www.instagram.com/bigobarskincare/https://bigobar.com/?srsltid=AfmBOopc3_AesoBcmd6chnib8JNAXrcz1O4JdMrVrxgx4iVGpF8GsxVkOur new Website is live! Check it out at:www.realityaftershow.comJoin our Patreon at RealityPatron.comIf you would like a cameo from Jonny Fairplay order one now! cameo.com/jonnyfairplayCheck us out on Tiktok @fairplaytokGet your shirt JUST like Jonny Fairplay at fairplayshirts.com#survivor #CBS #survivoraftershow #realityaftershow #RAS  #survivor51  #paramountplus Become a supporter of this podcast: https://www.spreaker.com/podcast/reality-after-show--5448874/support.

Join Survivor Legend Jonny Fairplay, and Watch the episode live. Watch as they breakdown Episode 2 of Survivor 51. We will be assessing all of the action from the episode and what we can expect from the Open Era! Stay tuned for all of our content this Survivor Season!Special thanks to our sponsor Big O Brand Skin care. Big O Brand has a special formula  of Ostrich Oil and is rich in Omega 3, 6, and 9! Bad strategy gets you voted out but bad skin care will leave you dry and your body dehydrated, Check out Big O Brand for all your skin care essentials and use PROMO CODE: Survivor at Checkout for 10% off! Tell them Fairplay sent you!  https://www.instagram.com/bigobarskincare/https://bigobar.com/?srsltid=AfmBOopc3_AesoBcmd6chnib8JNAXrcz1O4JdMrVrxgx4iVGpF8GsxVkOur new Website is live! Check it out at:www.realityaftershow.comJoin our Patreon at RealityPatron.comIf you would like a cameo from Jonny Fairplay order one now! cameo.com/jonnyfairplayCheck us out on Tiktok @fairplaytokGet your shirt JUST like Jonny Fairplay at fairplayshirts.com#survivor #CBS #survivoraftershow #realityaftershow #RAS  #survivor51  #paramountplus Become a supporter of this podcast: https://www.spreaker.com/podcast/reality-after-show--5448874/support.

Auto-generated transcript: Bismillāh ar-Raḥmān ar-Raḥīm, Alhamdulillāhi Rabbil ‘Alameen, wa salātu wa salamu ‘alā ashrafī al-anbiyā’ wal mursaleen, Muḥammadur Rasūlullāh ﷺ wa ‘alā ālihi wa sahbihi tashfeeman kaseeran kaseera. I’m sitting in Lusaka, the capital of Zambia, and on my balcony and all around me I see big beautiful trees. There is a tamarind tree right… Continue reading The real meaning of education

"Ak to chcete rozbiť, tak to rozbite," odkázal Robert Fico Andrejovi Dankovi a Tomášovi Tarabovi s dôvetkom, že on je pripravený aj na predčasné voľby s januárovým dátumom. Taraba zatiaľ stále ostáva ministrom, no Andrej Danko vypovedá poslušnosť a odkazuje, že hoci voľby nechce, SNS nebude poslúchať na slovo. Aká veľká je koaličná dráma? A čo môže byť na jej konci? V tejto chvíli je jasné len to, že Andrej Danko nemieni zložiť zbrane. Ako sú rozložené sily, analyzovala v podcaste Dobré ráno moderátorka Jana Krescanko Dibáková so zástupcom šéfredaktora denníka SME, komentátorom JAKUBOM FILOM. Zdroje zvukov: Aktuality, TA3, YouTube/SMER-SD Odporúčanie: Moji kolegovia z Piatočka pre vás pripravujú ďalšiu vedomostnú súťaž Nie alebo áno, v ktorej si môžete overiť svoje vedomosti zo sveta našej politiky. Bude v piatok 16. októbra v bratislavskom klube Metropol a hosťami budú Jakub Lužina a Rasťo Iliev. Lístky priamo na miesto, ale aj na livestream, nájdete na piatocek.com. – Všetky Podcasty SME nájdete na sme.sk/podcasty – Ďakujeme, že počúvate podcast Dobré ráno.See omnystudio.com/listener for privacy information.

In this episode of Targeted Talks, Benjamin Herzberg, MD, discusses the evolving treatment landscape for KRAS-mutant non–small cell lung cancer (NSCLC). He explains why KRAS matters to all oncologists, since these mutations drive roughly 30% of NSCLC cases, and reviews why chemoimmunotherapy remains the first-line standard of care for now. He also covers how central nervous system metastases affect treatment planning and why close collaboration with pathology and upfront biomarker testing are essential. Herzberg then turns to the pan-RAS inhibitor daraxonrasib (Rasonque), recently approved in pancreatic cancer, and explains why lung cancer clinicians should pay attention. He discusses its published lung cancer data, which show response rates and durability similar to those in pancreatic cancer, as well as the ongoing phase 3 trial vs docetaxel. He also discusses zoldonrasib, a G12D-specific inhibitor with a favorable tolerability profile, and the idea of a "RAS toolkit" of pan-RAS and allele-specific agents. He closes with the biggest unmet needs, including driver-negative disease and resistance to targeted therapy, and what excites him most: molecular glues and other novel drug modalities, including MTAP/PRMT5 inhibitors.

Góly-body-sekundy verejnoprávnej televízie patria k večerným klasikám a ona je ich stabilnou tvárou. Bývalá profesionálna tenistka a moderátorka Kristína Kucianová prijala pozvanie do podcastu suSPEAK na ŠPORT.sk. Moderátorom Rasťovi Konečnému a Marekovi Marušiakovi s úsmevom porozprávala o svojej ceste pred kamery, nepredvídateľnom živom vysielaní, dedinskom futbale, ale aj o skrytých tetovaniach a tvrdom boxe.Málokto o usmievavej Banskobystričanke vie, že predtým, ako sa udomácnila v televíznom štúdiu, strávila roky driny na kurtoch. Pôvodne ju to pritom ťahalo ku gymnastike, no v rodine napokon zvíťazila pragmatickosť a vybrala sa cestou tenisu.Neskôr sa po štúdiu v zahraničí zhodou vtipných náhod ocitla na kastingu do reality šou, kam prišla s mylnou predstavou, že sa hľadá moderátorka. Hoci miesto vtedy nezískala, producent v nej videl potenciál a poradil jej začať od piky. To ju priviedlo do regionálnej TV Hronka, kde si prešla kompletnou redaktorskou prácou od komunálnej politiky až po tvorbu vlastných historických dokumentov.„Vtedy do toho vstúpil môj ocino a povedal, že gymnastiku robiť nebudem, lebo si zničím telo a nič nezarobím,“ spomína s pobavením na zlomový moment z detstva, ktorý definitívne odštartoval jej dlhoročnú tenisovú dráhu.Do širšieho povedomia športových fanúšikov sa však zapísala najmä vďaka mimoriadne úspešnému projektu Iná liga. Viac ako päť rokov brázdila dedinské štadióny po celom Slovensku a mapovala nezameniteľnú atmosféru nižších súťaží. V uvoľnenej debate spomína na množstvo neštandardných zážitkov, podgurážených divákov nekontrolovane pobehujúcich po hracej ploche či milé stretnutia s lokálnymi pamätníkmi, ktorí jej prácu dodnes s úsmevom pripomínajú.Diskusia sa prirodzene preklopila k jej aktuálnemu pôsobeniu v STVR, kam sa presunula po úspešnom kastingu s Pavlom Gašparom. Prechod do celoštátneho živého vysielania so sebou priniesol obrovskú zodpovednosť, krkolomné brbty pri čítaní zložitých mien zahraničných hokejistov, no najmä náročné cestovanie. Týždenne strávi za volantom medzi domovom a Bratislavou dlhé hodiny, no napriek strate časti súkromia a fyzickej únave ju práca v redakcii nesmierne napĺňa a prípadnú kritiku či vtipné komentáre od divákov na sociálnych sieťach sa naučila brať s veľkým nadhľadom.Keď si potrebuje vyčistiť hlavu od mediálneho tlaku, navlieka si rukavice a trénuje box pod vedením bývalého zápasníka. Rovnako otvorená je aj v otázke svojich početných tetovaní, ktoré vníma ako istú formu psychoterapie, pričom ich pred zrakmi konzervatívnejších televíznych divákov dokáže vďaka vhodne zvolenému oblečeniu pred kamerami strategicky skrývať.Najnovšia epizóda podcastu suSPEAK na ŠPORT.sk prináša mimoriadne pútavý a humorný pohľad do sveta športovej žurnalistiky, o ktorom bežný fanúšik pred obrazovkou tuší len zriedka. Pustite si celú epizódu a spoznajte osobnosť, ktorá prešla od dedinských ihrísk až do hlavného vysielacieho času na STVR.

Góly-body-sekundy verejnoprávnej televízie patria k večerným klasikám a ona je ich stabilnou tvárou. Bývalá profesionálna tenistka a moderátorka Kristína Kucianová prijala pozvanie do podcastu suSPEAK na ŠPORT.sk. Moderátorom Rasťovi Konečnému a Marekovi Marušiakovi s úsmevom porozprávala o svojej ceste pred kamery, nepredvídateľnom živom vysielaní, dedinskom futbale, ale aj o skrytých tetovaniach a tvrdom boxe.Málokto o usmievavej Banskobystričanke vie, že predtým, ako sa udomácnila v televíznom štúdiu, strávila roky driny na kurtoch. Pôvodne ju to pritom ťahalo ku gymnastike, no v rodine napokon zvíťazila pragmatickosť a vybrala sa cestou tenisu.Neskôr sa po štúdiu v zahraničí zhodou vtipných náhod ocitla na kastingu do reality šou, kam prišla s mylnou predstavou, že sa hľadá moderátorka. Hoci miesto vtedy nezískala, producent v nej videl potenciál a poradil jej začať od piky. To ju priviedlo do regionálnej TV Hronka, kde si prešla kompletnou redaktorskou prácou od komunálnej politiky až po tvorbu vlastných historických dokumentov.„Vtedy do toho vstúpil môj ocino a povedal, že gymnastiku robiť nebudem, lebo si zničím telo a nič nezarobím,“ spomína s pobavením na zlomový moment z detstva, ktorý definitívne odštartoval jej dlhoročnú tenisovú dráhu.Do širšieho povedomia športových fanúšikov sa však zapísala najmä vďaka mimoriadne úspešnému projektu Iná liga. Viac ako päť rokov brázdila dedinské štadióny po celom Slovensku a mapovala nezameniteľnú atmosféru nižších súťaží. V uvoľnenej debate spomína na množstvo neštandardných zážitkov, podgurážených divákov nekontrolovane pobehujúcich po hracej ploche či milé stretnutia s lokálnymi pamätníkmi, ktorí jej prácu dodnes s úsmevom pripomínajú.Diskusia sa prirodzene preklopila k jej aktuálnemu pôsobeniu v STVR, kam sa presunula po úspešnom kastingu s Pavlom Gašparom. Prechod do celoštátneho živého vysielania so sebou priniesol obrovskú zodpovednosť, krkolomné brbty pri čítaní zložitých mien zahraničných hokejistov, no najmä náročné cestovanie. Týždenne strávi za volantom medzi domovom a Bratislavou dlhé hodiny, no napriek strate časti súkromia a fyzickej únave ju práca v redakcii nesmierne napĺňa a prípadnú kritiku či vtipné komentáre od divákov na sociálnych sieťach sa naučila brať s veľkým nadhľadom.Keď si potrebuje vyčistiť hlavu od mediálneho tlaku, navlieka si rukavice a trénuje box pod vedením bývalého zápasníka. Rovnako otvorená je aj v otázke svojich početných tetovaní, ktoré vníma ako istú formu psychoterapie, pričom ich pred zrakmi konzervatívnejších televíznych divákov dokáže vďaka vhodne zvolenému oblečeniu pred kamerami strategicky skrývať.Najnovšia epizóda podcastu suSPEAK na ŠPORT.sk prináša mimoriadne pútavý a humorný pohľad do sveta športovej žurnalistiky, o ktorom bežný fanúšik pred obrazovkou tuší len zriedka. Pustite si celú epizódu a spoznajte osobnosť, ktorá prešla od dedinských ihrísk až do hlavného vysielacieho času na STVR.

Join Survivor Legend Jonny Fairplay, Survivor 47's Gabe Ortis, and Producer Bobby Goodsby as we breakdown the Premiere of Survivor 51. We will be assessing each of the action from the Premiere and what we can expect from the Open Era! Stay tuned for all of our content this Survivor Season! Special thanks to our sponsor Big O Brand Skin care. Big O Brand has a special formula of Ostrich Oil and is rich in Omega 3, 6, and 9! Bad strategy gets you voted out but bad skin care will leave you dry and your body dehydrated, Check out Big O Brand for all your skin care essentials and use PROMO CODE: Survivor at Checkout for 10% off! Tell them Fairplay sent you! https://www.instagram.com/bigobarskincare/ https://bigobar.com/Our new Website is live! Check it out at: www.realityaftershow.comJoin our Patreon at RealityPatron.comIf you would like a cameo from Jonny Fairplay order one now! cameo.com/jonnyfairplayCheck us out on Tiktok @fairplaytokGet your shirt JUST like Jonny Fairplay at fairplayshirts.com #survivor #CBS #survivoraftershow #realityaftershow #RAS #survivor51 #paramountplus

On Ron's Amazing Stories this week, you asked for it... and that's exactly what you're going to get. This episode is built around listener emails and questions. We bring back an old RAS favorite, Johnny Is It True, with four stories from the history of the podcast. Elena wants to know if creepy listener stories are coming back. Caleb asks if Ron is real, how he researches the show, and whether he actually has a radio background. And Gideon has a request. After hearing a clip during our recent episode about sound effects, he wanted to hear the entire Gunsmoke story about the white buffalo. So we're making that happen. In This Episode Johnny Is It True Returns — Four stories from the history of Ron's Amazing Stories. Some involve listeners, some involve Ron doing questionable things behind a microphone... and at least one isn't quite what it seems. Are Listener Stories Coming Back? — Elena from Savannah, Georgia asks about the old creepy listener stories and whether These Are Your Stories might someday return. Q&A With Ron... Sort Of — Caleb from Boise, Idaho asks if Ron is an AI voice, how he researches the podcast, and what kind of radio background he actually has. Around The Bend — A familiar RAS song makes an appearance before we say goodbye. Featured Story Gunsmoke — "The Buffalo Killers" (June 7, 1952) Gideon from Burlington, Vermont heard part of this early Gunsmoke episode during our recent look at old-time radio sound effects and asked to hear the whole thing. William Conrad stars as Marshal Matt Dillon in a story involving two murdered buffalo hunters and one very unusual clue — a white buffalo pelt. It's an action-packed early episode of Gunsmoke, but listen closely to the sound effects. The horses, doors, footsteps, background sounds and, yes, plenty of gunfire help create a Dodge City you don't simply hear... you can almost see. Ron's Amazing Stories Is Sponsored by: Audible - You can get a free audiobook and a 30 day free trial at audibletrial.com/ronsamazingstories. Your Stories: Do you have a story that you would like to share on the podcast or the blog? Head to the main website, click on Story Submission, leave your story, give it a title, and please tell me where you're from. I will read it if I can. Links are below. Music Used In This Podcast: Most of the music you hear on Ron's Amazing Stories has been composed by Kevin MacLeod (incompetech.com) and is Licensed under Creative Commons: By Attribution 4.0. Other pieces are in the public domain. You can find great free music at FreePd.com which is a site owned by Kevin. Program Info: Ron's Amazing Stories is published each Thursday. You can download it from Apple Podcasts, stream it on YouTube or on the mobile version of Spotify. Do you prefer the radio? We are heard every Thursday at 10:00 pm and Sunday Night at 11:00 PM (EST) on AMFM247.COM. Check your local listing or find the station closest to you at this link. Social Links: Main Podcast Site by LibSynThe Blog Site by WordPressFacebook LinkTwitter Link Contact Links: EmailStory Submissions Contact Ron

In this episode of Roompact's RA*Chat, we're joined by Alyssa Fisher, a seasoned professional in residence life with a strong understanding of resident engagement and community building. Together, we explore how RAs can recognize subtle signs of isolation and connect with residents who may be quieter or less visible in their communities while noting the importance of consistency and community building.

Auto-generated transcript: Bismillāh ar-Raḥmān ar-Raḥīm. Al-ḥamdu lillāhi Rabbil-‘alāmīn. Wa salātu wa salāmu ‘ala ashraf al-anbiyā’ wal-mursalīn, Muḥammadin Rasūlallāh ﷺ, wa ‘ala ālihi wa sahbihi salāmun kāseran kāseran. My brothers and sisters, Alhamdulillah, Allāh subḥānahu wa ta’ālā sent Ādam alayhis-salām and Hāwā alayhis-salām, our ancestors, from Jannah to the earth. And Allāh subḥānahu wa ta’ālā has… Continue reading Return to Jannah

In this episode, host Jonathan Hughes sits down with MEFA's own Christina Davidson and Darina Barreto about their experiences being college Resident Advisors (RAs). As former RAs, they discuss how they made the decision to apply for the role, the benefits and responsibilities of the job, and advice for students considering becoming an RA. What does it take to be an RA? Listen to this episode to find out.

Schick and Nick believe the parody song jinx is over.  Colandrea !   Jeremiah Sirles has his moment.  Colorado sucks again.  Is anybody in college football great?  Nebraska vs Notre Dame coming not so soon.  Nick revisits the San Antonio skyline.  Ras could do the funniest thing.  Younger Nick calls a game-winning touchdown.  Running and pooping.  Michigan State prediction. Connect with us! SchickandNick.com Facebook, Twitter, or email  We would hate it if you missed an episode! So PLEASE subscribe, rate the pod, and throw us a review. It helps us out so much! We'd likey that.  This is another Hurrdat Media Production. Hurrdat Media is a podcast network and digital media production company based in Omaha, NE. Find more podcasts on the Hurrdat Media Network by going to HurrdatMedia.com or Hurrdat Media YouTube channel!

Some of the most remarkable advances in medicine are happening inside companies most of us have never heard of.For Christian investors, that raises an intriguing question: Could investing in healthcare innovation offer financial opportunity while also supporting businesses working to serve their neighbors and address some of the world's most difficult problems?Dr. Finny Kuruvilla believes it can.Kuruvilla is Co-Founder, Co-Chief Investment Officer, and Senior Portfolio Manager at Eventide Investments. With an M.D. and a Ph.D. in chemistry, he brings an unusual combination of medical, scientific, and investment expertise to faith-based investing.Where Faith, Medicine, and Investing MeetKuruvilla's interest in investing began long before he entered the investment industry.His parents immigrated to the United States from India in 1973 with very little. As his mother worked as a bank teller, she learned the fundamentals of investing and compound interest and began putting those principles into practice.Kuruvilla watched his parents work, save, give, and steadily improve their financial situation. Their example shaped his own understanding of financial stewardship.Years later, while completing an M.D.-Ph.D. program in Boston, Kuruvilla received a modest stipend and began saving and investing on his own. With encouragement from a roommate studying economics at Harvard, he spent years reading and learning about investing.One influence was legendary Fidelity investor Peter Lynch and his well-known principle of investing in what you know. For Kuruvilla, that meant bringing together two areas of expertise: medicine and investing.Eventually, he began to see that investing in medical innovation could potentially affect far more patients than he could reach through clinical practice alone.Business as a Tool for HealingKuruvilla treated patients with serious blood-related conditions, including leukemia, lymphoma, and sickle cell disease. Through that work, he became increasingly interested in the role businesses could play in accelerating medical innovation.That vision eventually led Kuruvilla and Robin John to co-found Eventide with Jason Myhre in 2008.Their approach is grounded in a distinctly Christian understanding of investing. Jesus commands His followers to love God and love their neighbors. If investing means owning businesses, Kuruvilla argues, Christians should consider how those businesses affect the people they serve.Businesses can provide products and services that meet genuine human needs. That means investors can consider not only what they want to avoid but also what kinds of businesses they want to support.Rather than viewing faith-based investing solely through the lens of screening out objectionable companies, Kuruvilla encourages investors to ask a positive question: What kinds of businesses contribute to the common good and serve their neighbors well?The Promise of Healthcare InnovationHealthcare provides a striking example.Kuruvilla points to recent developments in treating pancreatic cancer, historically one of the most difficult cancers to treat.Researchers have made progress targeting RAS, a protein that signals cells to divide. When RAS is mutated, that signal can remain active, allowing cancer cells to continue multiplying. Scientists have long considered RAS extraordinarily difficult to target, but new therapies are beginning to change that.For Kuruvilla, breakthroughs like these illustrate what can happen when scientific discovery, entrepreneurship, and investment capital work together.Investors provide capital to businesses. Those businesses can then use that capital to develop medicines, technologies, and services that address real human needs.For Christians, this creates an opportunity to think about investing as more than simply pursuing a return.A Positive Vision for Faith-Based InvestingScripture reminds us that creation has been deeply affected by the fall. Disease, suffering, and death are part of that brokenness. While medical innovation cannot ultimately overcome the effects of sin and death, it can relieve suffering and offer a measure of healing in the present.That gives Christians a compelling framework for thinking about healthcare innovation. Investing can support businesses developing treatments, improving lives, and serving people facing profound challenges.This doesn't mean financial returns are irrelevant. Investing still involves risk, and wise investors must evaluate companies carefully. But financial stewardship and concern for our neighbors do not have to be competing goals.As Kuruvilla explains, faith-based investing can move beyond asking only, “What should I avoid?” It can also ask, “What should I support?”That shift offers a broader vision of stewardship—one in which Christians consider how the capital entrusted to them might support businesses that promote human flourishing and love their neighbors well.To learn more about Eventide Investments and its approach to faith-based investing, visit FaithFi.com/Eventide.On Today's Program, Rob Answers Listener Questions:I received a $35,000 inheritance and would like to give part of it to two sisters serving as missionaries. Would that count as biblical giving, even if I don't give it through a local church? I'm 83, on a fixed income, and also wondering whether I should put some of the inheritance into my reverse-mortgage line of credit rather than give a full 10%.If someone has a testamentary trust along with payable-on-death and transfer-on-death designations, what assets would actually pass through the trust? Would it mainly cover personal property or anything left outside those beneficiary designations?Resources Mentioned:Become a FaithFi PartnerEventide InvestmentsMovement MortgageFaithful Steward: FaithFi's Quarterly MagazineFaithFi Field Guide: How Much Money is Enough? Our Ultimate Treasure: A 21-Day Journey to Faithful Stewardship by Rob WestWisdom Over Wealth: 12 Lessons from Ecclesiastes on MoneyLook At The Sparrows: A 21-Day Devotional on Financial Fear and AnxietyRich Toward God: A Study on the Parable of the Rich FoolFind a Certified Kingdom Advisor® (CKA)FaithFi AppDr. Finny Kuruvilla is the Co-Founder, Co-Chief Investment Officer, and Senior Portfolio Manager at Eventide Asset Management, LLC. Views expressed in this podcast are intended for information purposes and do not constitute investment advice. Eventide does not provide tax, accounting, or legal advice. Eventide's values-based approach to investing may not produce desired results and could result in underperformance compared with other investments. There is no guarantee that any investment will achieve its objectives, generate positive returns, or avoid losses. Remember, you can call in to ask your questions every weekday at (800) 525-7000. Faith & Finance is also available on Moody Radio Network and American Family Radio. You can also visit FaithFi.com to connect with our online community and partner with us as we help more people live as faithful stewards of God's resources. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Join Hosts Lauren Pratt and DONDI Season 2's Phillip Solomon as they welcome in guests Danni Boatwright (Survivor Guatemala and Winners At War), Lyrsa Torres (Survivor David vs. Goliath), and David Allsup (99 to Beat) to do our Survivor 51 Cast Draft! We will be assessing each of the Contestants leading into the Survivor 51 Premiere on September 23rd! Stay tuned for all of our content this Survivor Season!Special thanks to our sponsor Big O Brand Skin care. Big O Brand has a special formula  of Ostrich Oil and is rich in Omega 3, 6, and 9! Bad strategy gets you voted out but bad skin care will leave you dry and your body dehydrated, Check out Big O Brand for all your skin care essentials and use PROMO CODE: Survivor at Checkout for 10% off! Tell them Fairplay sent you! https://www.instagram.com/bigobarskincare/https://bigobar.com/?srsltid=AfmBOopc3_AesoBcmd6chnib8JNAXrcz1O4JdMrVrxgx4iVGpF8GsxVkOur new Website is live! Check it out at:www.realityaftershow.comJoin our Patreon at RealityPatron.comIf you would like a cameo from Jonny Fairplay order one now! cameo.com/jonnyfairplayCheck us out on Tiktok @fairplaytokGet your shirt JUST like Jonny Fairplay at fairplayshirts.com#survivor #CBS #survivoraftershow #realityaftershow #RAS  #survivor51 #Cast #assessment #paramountplus Become a supporter of this podcast: https://www.spreaker.com/podcast/reality-after-show--5448874/support.

Welcome to the Oncology Brothers podcast! In this episode, we dove deep into the groundbreaking advancements in pancreatic cancer treatment, focusing on the recent approval of daraxonrasib.   Join us as we welcome Mark Goldsmith, MD, PhD, CEO of Revolution Medicines, who shared his inspiring journey from clinical practice to the biotech industry. Discover the challenges and triumphs behind bringing this first-in-class drug to market, and learn about the significant impact it has on patient outcomes.   Keypoints: Daraxonrasib is a first-in-class RAS inhibitor approved for the treatment of pancreatic cancer, targeting a mutation present in over 90% of cases. The drug's development represents a major shift in pancreatic cancer, moving from a historically untreatable disease to a promising target for precision medicine. Early clinical trial results demonstrated remarkable tumor shrinkage, driving urgency to bring the therapy to patients. Management of side effects, including rash and gastrointestinal issues, is essential for optimal patient outcomes. Ensuring patient access—despite high treatment costs—remains a priority, with patient assistance programs and insurance navigation support in place. Future directions include combination therapies and the goal of transforming pancreatic cancer into a manageable chronic disease.   We discussed the critical gaps between academic research and community practice, the importance of understanding side effects, and the financial implications of new therapies. Dr. Goldsmith also highlighted the future of pancreatic cancer treatment and the ongoing commitment to improving patient care.   Whether you're a healthcare professional, a patient, or simply interested in the latest in oncology, this episode is packed with valuable insights and information.   Listen us on: Spotify: https://open.spotify.com/show/31BXhY9FM4gPWG10WgE11o  Follow us on social media: ⁠X/Twitter: https://x.com/oncbrothers  Instagram: https://www.instagram.com/oncbrothers  Website: https://oncbrothers.com/    Don't forget to like, subscribe, and hit the notification bell for more episodes on the latest in cancer treatment and research! #PancreaticCancer, #Daraxonrasib, #RASinhibitor, #DrugDevelopment, #OncologyBrothers

EVEN MORE about this episode!Your brain is constantly deciding what deserves your attention—but could your thoughts and beliefs be influencing what you notice every day? Julie Ryan talks with entrepreneur and Positive Activity™ co-creator Lori Rogers about how changing what she focused on transformed the way she responded to fear, uncertainty, caregiving, and some of the most difficult challenges of her life.Lori once described herself as a chronic “worrywart.” Then several crises collided: her business was struggling, her daughter suffered a severe concussion, and her son with autism was approaching adulthood. Instead of allowing fear to dictate what happened next, Lori began experimenting with simple daily practices involving gratitude, kindness, movement, meditation, and intentional focus.Julie and Lori explore the reticular activating system (RAS) and the role attention plays in determining which information we consciously notice. They discuss how repeated patterns of thought can influence our attention and behavior—and why changing those patterns may help us respond differently to the world around us.But this conversation goes much deeper than positive thinking.Lori explains why forced positivity doesn't work, how fear can interfere with intuition and decision-making, and why she began looking at difficult experiences as happening for her rather than simply to her.She also shares the remarkable story of her adult son Craig, who is nonspeaking and communicates through spelling. Lori describes the profound messages he has shared with her about God, love, consciousness, and the nature of life, and why she now considers him one of her greatest spiritual teachers.Julie and Lori also explore conscious creation, spiritual guidance, resilience, caregiving, manifestation, and a simple morning practice designed to help interrupt habitual thought patterns before they take over the day.If you've ever felt trapped in worry, fear, negative thinking, or circumstances you can't control, this conversation explores what may change when you become more intentional about where you place your attention.Guest Biography:Lori Rogers is the president and co-founder of Rogers Marketing, a multimillion-dollar woman-owned business where, for more than 25 years, she and her team have built lasting client relationships, driven franchise-leading sales, and earned recognition for leadership in their industry. She is also the caregiver of her adult son, who was diagnosed with autism, an experience that inspired her advocacy for individuals with special needs and their families. Lori co-founded PASE—Parents Assisting Special Educators—to provide vital equipment and supplies to special education classrooms and teachers, and founded Life-Op to create safe, productive learning environments for adults with special needs. A passionate Spelling to Communicate (S2C) advocate, Lori has dedicated herself to expanding opportunities and support for nonspeaking individuals. In 2011, she began incorporating the practices of Positive Activity™, experiencing profound shifts in both her professional success and her approach to caregiving. Today, she shares these principles with others, teaching simple daily practices and mindset shifts designed to foster greater positivity, possibility, and meaningful transformation in business, caregiving, and everyday life.Episode Chapters:(0:00:00) Can Your Thoughts Change the Life You Experience? (0:06:27) Your Brain Is Filtering More Than You Realize (0:09:31) How Fear Can Block Intuition & Guidance (0:12:45) The Crises That Forced Lori to Change Her Thinking (0:23:01) Her Nonspeaking Son Became Her Spiritual Teacher (0:37:47) Simple Daily Habits That Can Shift Your Mindset (0:56:00) Are We Consciously Creating Our Lives? (1:02:44) The 2-Minute Morning Shift to Start Tomorrow➡️Subscribe to Ask Julie Ryan YouTube➡️Subscribe to Ask Julie Ryan Español YouTube➡️Subscribe to Ask Julie Ryan Português YouTube➡️Subscribe to Ask Julie Ryan Deutsch YouTube➡️Subscribe to Ask Julie Ryan Français YouTube✏️Ask Julie a Question!

Join Survivor Legend Jonny Fairplay, Survivor Caramoan's Matt Bischoff, and Producer Bobby Goodsby as we breakdown the second rumored tribe for Survivor 51 in our Savu Tribe Preview Podcast. We will be assessing each of the Tribes leading into the Survivor 51 Premiere on September 23rd! Stay tuned for all of our content this Survivor Season!Special thanks to our sponsor Big O Brand Skin care. Big O Brand has a special formula  of Ostrich Oil and is rich in Omega 3, 6, and 9! Bad strategy gets you voted out but bad skin care will leave you dry and your body dehydrated, Check out Big O Brand for all your skin care essentials and use PROMO CODE: Survivor at Checkout for 10% off! Tell them Fairplay sent you! https://www.instagram.com/bigobarskincare/https://bigobar.com/?srsltid=AfmBOopc3_AesoBcmd6chnib8JNAXrcz1O4JdMrVrxgx4iVGpF8GsxVkOur new Website is live! Check it out at:www.realityaftershow.comJoin our Patreon at RealityPatron.comIf you would like a cameo from Jonny Fairplay order one now! cameo.com/jonnyfairplayCheck us out on Tiktok @fairplaytokGet your shirt JUST like Jonny Fairplay at fairplayshirts.com#survivor #CBS #survivoraftershow #realityaftershow #RAS  #survivor51 #Cast #assessment #paramountplus Become a supporter of this podcast: https://www.spreaker.com/podcast/reality-after-show--5448874/support.

On Ron's Amazing Stories this week, we're taking a trip through history — although perhaps not the kind you remember from school. We'll begin with the return of an old RAS segment, Not So Important Times in History. This time, we look at an international crisis that happened practically in my own backyard that nearly started a war between the United States and Great Britain. Then Suspense puts its own fictional spin on history with A Friend to Alexander, a strange tale involving dreams, Aaron Burr, Alexander Hamilton, and a famous duel. Finally, we climb aboard the old-time-radio time machine with You Are There. CBS reporters take us back to July 11th, 1804, to cover the Burr-Hamilton duel as though it were happening live. And somewhere along the way, we may even find out what happened to a pig. In This Episode • Not So Important Times in History: The Pig War — The strange 1859 incident that brought American and British forces face-to-face over the shooting of a pig. • Suspense: A Friend to Alexander — A man's dreams about Aaron Burr begin taking on some disturbingly familiar faces. Originally broadcast August 3rd, 1943. • You Are There: The Burr-Hamilton Duel — CBS turns one of America's most famous historical events into a live radio news report. Originally broadcast January 11th, 1948. Our surviving recording is incomplete. Featured Stories A Friend to Alexander from Suspense — August 3, 1943 History provides the inspiration for this unusual Suspense story about a man whose dreams carry him into the world of Aaron Burr and Alexander Hamilton. But when the people in those dreams begin resembling people from his own life, history and reality start getting a little too close for comfort. The Burr-Hamilton Duel from You Are There — January 11, 1948 You Are There had a wonderful idea: take CBS radio reporters and send them into the past to cover history as breaking news. This time the microphones are waiting in Weehawken, New Jersey, as Alexander Hamilton and Aaron Burr prepare for their famous duel. Ron's Amazing Stories Is Sponsored by: Audible - You can get a free audiobook and a 30 day free trial at audibletrial.com/ronsamazingstories. Your Stories: Do you have a story that you would like to share on the podcast or the blog? Head to the main website, click on Story Submission, leave your story, give it a title, and please tell me where you're from. I will read it if I can. Links are below. Music Used In This Podcast: Most of the music you hear on Ron's Amazing Stories has been composed by Kevin MacLeod (incompetech.com) and is Licensed under Creative Commons: By Attribution 4.0. Other pieces are in the public domain. You can find great free music at FreePd.com which is a site owned by Kevin. Program Info: Ron's Amazing Stories is published each Thursday. You can download it from Apple Podcasts, stream it on YouTube or on the mobile version of Spotify. Do you prefer the radio? We are heard every Thursday at 10:00 pm and Sunday Night at 11:00 PM (EST) on AMFM247.COM. Check your local listing or find the station closest to you at this link. Social Links: Main Podcast Site by LibSynThe Blog Site by WordPressFacebook LinkTwitter Link Contact Links: EmailStory Submissions Contact Ron

Auto-generated transcript: Bismillāh ar-Raḥmān ar-Raḥīm. Al-ḥamdu lillāhi Rabbil-‘Ālamīn, wa salātu wa salāmu ‘alā yashārak wa ilā anbiyā’ wal-mursalīn Muḥammadur Rasūlallāh ﷺ, wa ‘alā ālihi wa sahbihi wa sallamu tasliman kathīran kathīra. Umarabadu brothers and sisters, we are looking at the advice of Fatima Rasam Rahmatul Ali which he gave with respect to the truths of… Continue reading Lessons from Hatim Al Asamm – 4 – There is no discrimination in Islam

Le volume 18 de l'indispensable série 100% Duplates est en ligne chez Reggae-Unite et sur son bandcamp ! Gros big up aux artistes et à MaxHim pour cette collection qui ne cesse de s'enrichir au fil des années et aux mentions de plus en plus nombreuses à BC qui j'avoue font bien plaisir ! 1-Ras […]

Good morning from Pharma Daily: the podcast that brings you the most important developments in the pharmaceutical and biotech world. First, let's delve into the innovative work being done by Grove Biopharma. Founded in 2020 in Chicago, this company is at the forefront of developing polymer-peptide hybrids to target intracellular protein-protein interactions, areas traditionally deemed undruggable. These interactions are crucial regulatory components in numerous cellular processes and are implicated in diseases like cancer and neurodegenerative disorders. However, their smooth protein surfaces present a challenge for traditional small molecule drugs, which struggle to find suitable binding pockets. Similarly, biologics like antibodies and peptides, despite their high binding affinities, face difficulties penetrating cell membranes due to their size and instability. Grove Biopharma addresses these issues through its proprietary Bionics Biologics™ technology. Developed by Nathan Gianneschi at Northwestern University, this approach uses protein-like polymers to mimic proteins with enhanced stability and cellular penetration. These polymers, adorned with peptide branches via living polymerization, maintain peptide binding properties while overcoming previous limitations in drug delivery. This breakthrough has already shown promise in preclinical studies. A 2023 study in Science Advances revealed the efficacy of targeting membrane protein CD36 for treating macular degeneration in mice, while a 2024 study demonstrated PLPs' ability to penetrate neurons and target mitochondria in Huntington's disease models. Moreover, a 2026 Nature Communications publication introduced HYDRAC, a new PLP class capable of degrading MYC and KRAS proteins, reducing tumor growth in mice. Grove Biopharma's pipeline is robust, targeting key areas in cancer and neurodegeneration. Despite challenges typical of the biotech landscape—such as toxicity concerns during clinical trials and scalability issues—Grove's unique platform offers the flexibility needed to address multiple targets effectively. Shifting focus to industry-wide developments, recent advancements highlight significant strides in personalized medicine. Moderna and Merck's mRNA cancer vaccine has shown promising results in a phase 3 study, marking an important step forward for customized healthcare approaches based on genetic profiles. This not only offers hope for cancer treatment but also signifies a wider shift towards more tailored therapeutic strategies. Regulatory updates also play a critical role in shaping industry dynamics. The appointment of Dr. Angelo De Claro as chief of the FDA Oncology Center of Excellence is pivotal. His focus on modernizing regulatory practices aims to expedite drug approvals while ensuring that innovative treatments reach patients more swiftly. However, the FDA's decision to delay approval for Exelixis' tyrosine kinase inhibitor with Roche's Tecentriq underscores the complexities involved in novel therapies' assessments. On the geographical front, Singapore's launch of a biotech hub in Boston highlights the global nature of biotech development. This move strengthens historical ties and emphasizes international collaboration's importance in accelerating scientific research. In clinical trials, AbbVie's success with Qulipta (atogepant) for menstrual migraine prevention is noteworthy. It not only expands therapeutic options for women but also underscores a growing focus on gender-specific health issues within clinical research. Meanwhile, new RAS-targeting therapies continue to emerge as Revolution Medicines' Rasonque gains approval for advanced pancreatic cancer treatment—a significant milestone in addressing previously undruggable mutations. Industry dynamics are further illustrated by leadership changes at major firms like Takeda. The departure of long-time R&D chief Andy Plump often signals strategic shifts that could influence research priorities and corporate focus. Novartis recently faced setbacks with late-stage asset failures impacting its market position and raising investor concerns about its strategic direction concerning mergers and acquisitions. On a similar note, Takeda undergoes organizational changes amid potential strategic shifts following its CEO appointment—demonstrating volatility within companies striving for competitive advantage through effective leadership. Promising developments at the FDA include solidifying leadership with Karim Mikhail at CBER and Michael Davis at CDER—crucial appointments ensuring operational stability amidst past disruptions under former commissioner Marty Makary—and appointing Jared Seehafer as deputy commissioner focusing on AI integration into regulatory processes. Significant financial movements continue highlighting investor interest: Frazier adds over $1 billion targeting small-mid-sized biotech firms while Samsung Biologics secures manufacturing deals emphasizing strategic partnerships' importance globally. Scientific developments also reveal challenges; Silence Therapeutics maintains polycythemia vera leadership despite emerging hurdles while Novo Nordisk halts heart disease studies reflecting complexities validating interleukin-6 as therapeutic targets. AI integration gains momentum transforming operational efficiencies across various functions from R&D to human resources optimizing overall effectiveness within life sciences organizations—a trend poised to reshape people strategy profoundly impacting medical affairs evidenced evaluations enhancing decision-making processes ultimately improving patient outcomes significantly moving forward amidst this dynamic industry landscape filled with opportunities and risks requiring agility and forward-thinking strategies to capitalize on emerging scenarios efficiently and effectively ensuring continued success thriving amidst transformations occurring rapidly around us today, tomorrow, and beyond!Support the show

Auto-generated transcript: Bismillāh ar-Raḥmān ar-Raḥīm, Alhamdulillāhi Rabbil ‘Alameen, wa salātu wa salāmum ‘alā ash-shadhab bi-anbiyā’ wal-mursalīn, Muḥammadur Rasūlullāh ﷺ, tas-salēeman kathīran. I think it was 1997 or ’98; I went to San Francisco to teach a course for AMA International, which is the largest training company in the world. So, I landed in the afternoon.… Continue reading Movie is over

Revolution Medicines recently made history with the approval of its RAS inhibitor Rasonque for advanced pancreatic cancer. But behind RevMed is an entire field of biotechs working to broaden the reach of RAS-targeting drugs. In this week’s episode of “The Top Line,” Fierce Biotech’s Darren Incorvaia sits down with Verastem Oncology CEO Dan Paterson and Chief Scientific Officer Jonathan Pachter, Ph.D., to discuss the significance of Revolution Medicines’ recent pancreatic cancer approval, Verastem’s work in the RAS-targeting space and how the company is trying to improve on existing approaches. To learn more about the topics in this episode: FDA greenlights Revolution Medicines' pancreatic cancer gamechanger As RevMed preps for ‘historic’ pancreatic cancer launch, questions linger on the ground ASCO: Revolution Medicines confident in RAS leadership as rivals square up AACR: Revolution sees pancreatic cancer win as 'tip of the iceberg' as RAS wave rises Fierce 50 of 2026: Breakthrough honoree Verastem Oncology Fierce 50 of 2026: Breakthrough honoree Revolution Medicines See omnystudio.com/listener for privacy information.

On Ron's Amazing Stories this week, we're listening a little differently. Our main focus is sound effects and the remarkable people who created them. On The RAS Signal, we explore how sound-effects artists could build an entire world using little more than everyday objects, ingenuity, and a well-placed microphone. Then we head into the Inner Sanctum for a tale involving murder, revenge, thirty pieces of silver, and one very unusual clock. We'll also bring back another old RAS favorite — Q&A with Ron — with listener questions about the changing podcast and how classic science-fiction radio created sounds for things that didn't even exist. In This Episode The RAS Signal: Sound Effects — A look behind the microphone at the artists, equipment, and techniques that helped listeners see with their ears. Inside the Inner Sanctum — We talk about producer Himan Brown, Raymond Edward Johnson, that famous squeaking door, and how commercials became part of the program itself. The Judas Clock — A classic 1945 episode of *Inner Sanctum Mysteries*, presented with its original Lipton Tea commercials intact. Q&A with Ron Returns — Mary and Brandon ask about the direction of the podcast, while Leo takes us back into the world of classic radio sound effects — including spaceships, magnetic tape, electronic circuits... and even a cow. Featured Story The Judas Clock — Inner Sanctum Mysteries (April 17, 1945) Thirty years ago, a man was murdered using a strange clock said to require the thirty pieces of silver paid to Judas Iscariot for his betrayal of Jesus. Now the murdered man's son has returned — and he has plans for The Judas Clock. This episode includes its original commercials. Inner Sanctum often blended its advertising directly into the program, and removing the Lipton Tea spots would take away part of the character and atmosphere of the original broadcast. Ron's Amazing Stories Is Sponsored by: Audible - You can get a free audiobook and a 30 day free trial at audibletrial.com/ronsamazingstories. Your Stories: Do you have a story that you would like to share on the podcast or the blog? Head to the main website, click on Story Submission, leave your story, give it a title, and please tell me where you're from. I will read it if I can. Links are below. Music Used In This Podcast: Most of the music you hear on Ron's Amazing Stories has been composed by Kevin MacLeod (incompetech.com) and is Licensed under Creative Commons: By Attribution 3.0. Other pieces are in the public domain. You can find great free music at FreePd.com which is a site owned by Kevin. Program Info: Ron's Amazing Stories is published each Thursday. You can download it from Apple Podcasts, stream it on YouTube or on the mobile version of Spotify. Do you prefer the radio? We are heard every Thursday at 10:00 pm and Sunday Night at 11:00 PM (EST) on AMFM247.COM. Check your local listing or find the station closest to you at this link. Social Links: Main Podcast Site by LibSynThe Blog Site by WordPressFacebook LinkTwitter Link Contact Links: EmailStory Submissions Contact Ron

Auto-generated transcript: Bismillāh ar-Raḥmān ar-Raḥīm, wa raḥmatullāhi wa barakatuhu, wa bil-‘amīn. Wa salātu wa salām ‘alā ašrafil-anbiyā’ wal-mursalīn, Muḥammadur-Rasūlullāh ﷺ, taseemun kathīrun kathirah. Wa ma ba’du. My brothers and sisters, every day we get a reminder that the day is coming when we will meet Allah ﷻ. Yesterday at Maghrib time, a very dear friend… Continue reading Say Allah is my Rabb and be steadfast

Please visit answersincme.com/BHT860 to participate, download slides and supporting materials, complete the post test, and get a certificate. Presented by Sara Stafford, MDCM, FRCPC and Gihane Zarifa, MD, CCFP, FCFP, MSc. In this activity, experts in family medicine and endocrinology discuss the role of oral glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) in personalized type 2 diabetes (T2D) management. Upon completion of this activity, participants should be better able to: Discuss individualized, guideline-informed management strategies for T2D that address glycemic control, weight, and patient-specific factors; Differentiate key pharmacologic, administration, and tolerability characteristics of oral GLP-1 RAs to support patient counseling in T2D; and Interpret clinical evidence for approved and emerging oral GLP-1 RAs to inform their potential role in addressing gaps in T2D management.

Join Survivor Legend Jonny Fairplay, Survivor 47's Gabe Ortis, and Producer Bobby Goodsby as we breakdown the first rumored tribe for Survivor 51 in our Toka Tribe Preview Podcast. We will be assessing each of the Tribes leading into the Survivor 51 Premiere on September 23rd! Stay tuned for all of our content this Survivor Season!Special thanks to our sponsor Big O Brand Skin care. Big O Brand has a special formula of Ostrich Oil and is rich in Omega 3, 6, and 9! Bad strategy gets you voted out but bad skin care will leave you dry and your body dehydrated, Check out Big O Brand for all your skin care essentials and use PROMO CODE: Survivor at Checkout for 10% off! Tell them Fairplay sent you!https://www.instagram.com/bigobarskincare/https://bigobar.com/?srsltid=AfmBOopc3_AesoBcmd6chnib8JNAXrcz1O4JdMrVrxgx4iVGpF8GsxVkOur new Website is live! Check it out at: www.realityaftershow.comJoin our Patreon at RealityPatron.comIf you would like a cameo from Jonny Fairplay order one now! cameo.com/jonnyfairplayCheck us out on Tiktok @fairplaytokGet your shirt JUST like Jonny Fairplay at fairplayshirts.com#survivor #CBS #survivoraftershow #realityaftershow #RAS #survivor51 #Cast #assessment #paramountplusBecome a supporter of this podcast: https://www.spreaker.com/podcast/reality-after-show--5448874/support.

Living in the residence halls is about more than having a place to sleep. For many students, it's where college truly begins. It's where many make their first friends, learn to live with others, and experience independence for the first time. In this special episode, we kick off the new school year with students and RAs who share honest stories and advice about roommates, community, conflict, parents, and finding your place within one of the most defining college experiences.

In this episode of Beyond the Torch, Leslie Nease and guest-co-host, Courtney Yates, chat with Billy Garcia from Survivor: Cook Islands to revisit his memorable season, including the infamous "we love you, I love you" moment with Candice. Billy shares never-before-seen behind-the-scenes stories — from being accidentally set on fire during a challenge and dealing with a painful recovery, to clashing with tribemate JP, forming a secret alliance with Candice before the game even began, and navigating a controversial strategy where his tribe intentionally threw a challenge. He reflects candidly on being gaslit during the game (a concept he didn't have a name for at the time), how his approach to Survivor would differ if he played today, and his enduring friendships within the Survivor community. The episode opens with a fan-submitted question about which Survivor vote each guest would change, sparking a lively discussion about Parvati, Sandra, and Richard Hatch's legacies in the game.Special thanks to our sponsor Big O Brand Skin care. Big O Brand has a special formula of Ostrich Oil and is rich in Omega 3, 6, and 9! Bad strategy gets you voted out but bad skin care will leave you dry and your body dehydrated, Check out Big O Brand for all your skin care essentials and use PROMO CODE: Survivor at Checkout for 10% off! Tell them Fairplay sent you!https://www.instagram.com/bigobarskincare/https://bigobar.com/?srsltid=AfmBOopc3_AesoBcmd6chnib8JNAXrcz1O4JdMrVrxgx4iVGpF8GsxVkOur new Website is live! Check it out at: www.realityaftershow.comJoin our Patreon at RealityPatron.comIf you would like a cameo from Jonny Fairplay order one now! cameo.com/jonnyfairplayBecome a supporter of this podcast: https://www.spreaker.com/podcast/reality-after-show--5448874/support.

Episode 406 explains how movement prepares the brain but does not guarantee learning. It traces the full sequence—movement, RAS-driven readiness, salience and relevance, focused attention, encoding, retrieval and repetition, and recovery and sleep—that turns activation into lasting memory and performance. The episode offers practical steps in a Move–Focus–Learn protocol: use brief movement to create readiness, clearly identify and remove distractions for one learning target, interact with material in meaningful ways, practice retrieval and spaced repetition, and protect recovery to support consolidation. Listeners are encouraged to test these simple experiments for school, work, or personal learning to make experience more usable and improve attention, memory, and performance. ON THIS EPISODE, YOU'LL LEARN: ✔ Why movement prepares the brain but does not guarantee learning ✔ How attention directs the capacity movement creates ✔ Why meaning and emotional relevance capture attention ✔ The difference between paying attention and actually learning ✔ How retrieval and repetition help new information stick ✔ How seeing, hearing, explaining, and applying an idea can help us remember it ✔ How restorative sleep supports memory and learning ✔ A practical Move–Focus–Learn Protocol for school, work, or your own personal learning The central idea is simple: Movement opens the window. Attention determines what enters. Repetition strengthens what remains. And recovery helps the brain integrate what it has experienced. Welcome back to the Neuroscience Meets Social and Emotional Learning Podcast, where we bridge neuroscience, social and emotional learning, and human performance so we can create measurable improvements in our well-being, achievement, leadership, productivity, and results. I'm Andrea Samadi, and if you've been following along through Season 16, you'll know that we have been building what I call The Brain's Operating System for Human Performance—a neuroscience-based framework designed to help us understand how the different systems of the brain and body work together to influence how we learn, adapt, connect, lead, and ultimately, how we perform. We are currently in Phase 3, focused on Movement, Learning, and Cognition. As I prepared for this phase, I went back through more than 400 episodes of the podcast and organized them according to the five phases of this framework. I wanted to see whether any patterns would emerge. And some did. Phase 1, Regulation and Safety, includes 57 episodes. Phase 2, Neurochemistry and Motivation, includes 41 episodes—the smallest category, possibly because this is the area I have explored the least with my learning. Phase 3, Movement, Learning, and Cognition, includes 174 episodes—the largest category by far. Phase 4, Perception and Social Intelligence, includes 68 episodes. And Phase 5, Integration and Meaning, includes 71 episodes. When I saw that 174 episodes—more than 40 percent of the entire podcast—fit into Movement, Learning, and Cognition, it immediately showed me where much of my curiosity has been directed over the years. I have always been fascinated by learning: How do we prepare the brain to learn? What captures our attention? Why do some ideas (or people) remain with us while others disappear? How does knowledge become something we can retrieve, apply, and actually use to improve our lives? And while I am spending most of my spare time hiking, or at the gym over the years, I wonder, how does this movement that I'm doing help to improve my attention, or memory, and finally, where does recovery fit into this process? The past few weeks, I'm finally connecting the dots with how important recovery is with this equation. I'm also learning how to determine what's important to me. John Medina's Brain Rules book explains what holds our attention. He reminds us that “we don't pay attention to boring things (or people).[i] As we continue through these five phases of The Brain's Operating System for Human Performance, I'm especially curious about how we will move beyond understanding these lessons, to begin implementing what we are learning, and connecting more ways to improve how we learn, adapt, connect, lead, and ultimately perform in our day to day lives. That will become an important part of the upcoming workbook—which is a practical way for each of us to identify what we have already strengthened, where gaps may remain, and which specific actions can help us to improve our own learning, well-being, and performance. Because the purpose of this 5 Phase Framework is not simply to collect more information about the brain. It is to understand how the systems connect—and then use that understanding to create meaningful change.  “Attention Is the Gate—How Movement Becomes Learning.” For today's Episode 406, we'll connect Dr. John Medina's Brain Rules to the Movement Loop we have been building throughout Phase 3—and answer the next important question: Once movement activates and prepares the brain, what determines whether that readiness becomes lasting learning? You can review our full interview with John Medina from EP 42[ii] from February 2020. (find the link in the reference section of the show notes). INTRODUCTION: THE MISSING STEP We have spent this phase so far, examining how movement changes the brain. Dr. Chuck Hillman and Paul Zientarski[iii] showed us that movement prepares the brain for learning. Dr. John Ratey[iv] helped us understand how exercise influences neurochemistry, BDNF, and neuroplasticity. Dr. Kristen Holmes[v] showed us that recovery helps determine whether strain becomes adaptation. And our restorative-sleep episode explored where some of that recovery, adaptation, and integration may occur. But one important question remains: A brain can be activated, chemically prepared, and physiologically ready—but what determines what it actually learns? The answer begins with attention. Movement may create the readiness to learn, but readiness alone is not learning. The brain must still select what matters, focus on it, interact with it, encode it, revisit it, and eventually integrate it. That gives us the pathway we will explore today: Movement creates readiness. But what is the filter in our brain that helps us to focus on the things that are most important to us. What gives us the ability to pay attention to something? The RAS- or The Reticular Activating System. Before we continue, let's remind ourselves what the RAS is. The RAS—or reticular activating system—is a network of neurons extending through the brainstem that helps regulate wakefulness, alertness, and our readiness to respond to incoming information. We explored this system previously in Episode 272, “Priming the Reticular Activating System to Achieve Our Goals.” In that episode, we described the RAS as a type of filter that helps us notice information connected to what we have identified as important. For example, once you decide that you are interested in a particular type of car, you may suddenly begin seeing that car everywhere. That's the RAS filtering system in our brain. The cars were already there, but your attention now has a reason to prioritize them. In Episode 272[vi], we applied this idea to goal-setting. When we clearly identify an intention, we may become more likely to notice relevant information, opportunities, and connections that were previously present but did not receive our attention. That explanation gave us a useful starting point. But here in Episode 406, we can add more precision. The RAS is not a tiny gatekeeper sitting in the brain and personally deciding what we will learn. It is part of a broader network that helps maintain the level of arousal and alertness required for our attention. It helps the brain become available to notice whatever it is that is important to us. Then salience, relevance, emotion, intention, and our current goals help determine what receives priority. Focused attention directs our limited cognitive resources toward the selected information. Next, encoding and repetition help strengthen what we want to focus on. And recovery and sleep help to further support its consolidation and integration. So our expanded Movement Loop now looks like this: you can see an image in the show notes to expand this understanding. Movement supports brain activation.   RAS helps the brain become awake, alert, and ready to pay attention. Salience and relevance (or what matters the most to us) helps to determine what receives priority. Our focused attention selects what gets our priority. Encoding and repetition further strengthens this pathway. Recovery and sleep (that we've dove deep into) support consolidation and integration. And together, these processes increase the likelihood that experience becomes learning—and that learning becomes available for future performance. Whatever it is that we have put our attention on, is now made usable.  This shows us how our understanding has evolved since Episode 272, three years ago. Then, we were asking: How can our intention help us notice what matters with the attainment of our goals? Now, years later, with more understanding, we are asking: Once the brain is alert and something important has captured our attention, what sequence of events must occur for that information to become lasting learning? We are no longer asking only what must remain top of mind so we can notice opportunities connected to our goals. We are asking what happens next: How does something we notice become something we understand? How does something we understand become something we remember? And how does something we remember become knowledge or a skill we can retrieve, apply, and use to improve our performance? This is where Dr. John Medina's Brain Rules help us to connect the pieces. Let's begin with Lesson One: Lesson 1: Movement Creates Readiness—Not Guaranteed Learning Movement can increase alertness, circulation, and readiness for cognitive work. But why might movement have such a powerful relationship with the brain? Dr. John Medina explains this through an evolutionary lens. His point is that the human brain did not develop while we were sitting motionless at desks or staring at screens. It developed while human beings were moving through changing outdoor environments, solving immediate problems, and continually responding to the world around them. Let's listen to how he explains it. CLIP 1 John Medina “The human brain was designed to solve problems related to surviving in an outdoor setting, in unstable meteorological conditions—and to do so in constant motion. The constant motion is where the exercise comes in. But the rest of that—the more a school, or any of us, can recreate the world of the Serengeti, the place where this brain actually grew up, the better things are. And exercise, particularly outdoor exercise, is a terrific example of this idea.” When Medina refers to the Serengeti, I don't think he is suggesting that schools should literally recreate the dangers or conditions of an ancient environment. He is giving us an evolutionary picture of the conditions under which the human brain developed: We moved. We navigated changing environments. We encountered new sensory information. We solved problems. We adapted to uncertainty. And we did these things together rather than remaining physically still for most of the day. Outdoor movement may bring several of these conditions together. We are moving our bodies while also responding to changes in light, temperature, terrain, sound, distance, and direction. This helps explain why movement belongs at the beginning of our Movement Loop. But it also brings us to an important distinction: Movement creates readiness. It does not guarantee learning. A student can move before class and still become distracted. A leader can exercise before work and still spend the morning reacting to notifications. An athlete can warm up physically without becoming mentally focused on the strategy or skill required next. Movement can help activate the system. The RAS in the brain helps us become awake and alert. But the brain must still determine what stands out, what is relevant, and what deserves focused attention. Movement opens the window. Attention determines what enters through it. Our Key lesson: Movement prepares the brain. Attention directs the preparation. PUT THIS INTO ACTION Before your next period of demanding cognitive work, use movement to create a window of readiness. Take a five-to-ten-minute walk, complete a brief movement break, stretch, or choose another form of movement appropriate for your ability and environment. But do not move without deciding what comes next. Before you begin, identify the specific task you will return to: “When this movement break ends, what will receive my attention?” For a student, it might be the first problem on a math assignment. For a leader, it might be the one decision that requires uninterrupted thinking. For an athlete, it might be the cue, strategy, or skill that needs to remain at the center of practice. Movement creates the opportunity. A clear intention helps direct what happens next. Your experiment is: Move briefly, choose one target that you want to complete with this intention, and begin that task immediately after the movement ends. Lesson 2: Attention Is the Gate In EP 395[vii], we examined what captures attention: Meaning Emotion Relevance Intention Reward Human connection Now today's episode shows how we move beyond why the brain notices something and explains what attention does after movement has prepared the system to learn. Attention acts as a filter. The brain encounters more information than it can consciously process, so it must select what receives priority. This creates the bridge: Brain activation creates capacity. Attention distributes that capacity. Our Key lesson: What the brain does not attend to has little opportunity to become lasting learning. Andrea's Application This distinction between brain capacity and cognitive efficiency became personal for me when I reviewed the results of my 2020 brain scan. We covered this topic on EP 84[viii] and we will do a thorough review of what was learned with our brain scans at Dr. Daniel Amen's CA Clinic. The evaluation that I received after my scan was completed with Dr. Shane Creado, suggested that I had areas of strong capacity, but that my brain appeared to be working harder than necessary to complete certain tasks in the cognitive testing. A possible contributor we discussed was sleep deprivation. I want to be careful here: a SPECT scan is not a direct measurement of attention or learning, and my results cannot tell us that insufficient sleep caused a specific attention pattern. But the experience gave me a useful way to think about what we are learning today. Having cognitive capacity does not necessarily mean that we are using that capacity efficiently. I may be motivated, active, and ready to work—but if I am under-recovered, under-slept, distracted, or trying to process too many competing inputs, my brain may have to expend more energy to sustain focus. This helped me understand the Movement Loop at a more personal level: Movement can help activate my brain. Attention gives that activation a target. But recovery may influence how efficiently I can sustain that attention and use it for learning. My scan did not define what my brain could do. It gave me another reason to examine the conditions under which my brain performs at its best. PUT THIS INTO ACTION Before asking yourself—or someone else—to focus, make the target of attention clear. Start by completing this sentence: “The most important thing to notice right now is…” Then reduce the competition around it. We all know to do this. Silence unnecessary notifications. Close unrelated tabs. Remove extra materials from view. Avoid asking the brain to switch repeatedly between tasks. If you are teaching, make the relevance visible: “Why does this matter?” “What should students be listening or looking for?” “How does this connect to something they already know?” If you are working independently, write your one priority clearly where you can see it. Remember, the goal is not to force the brain to attend to everything. The goal is to help it identify (with your RAS-that filter in your brain) what deserves your priority. Your experiment is: Choose one target, (something you want to accomplish) remove as many unnecessary sources of interference as possible, and create one meaningful reason to pay attention. This also helps explain why keeping your desk clear, your closet organized, or your car tidy may make you feel calmer and more focused. How we do anything is how we do everything. Every object, notification, unfinished task, or piece of visual clutter can become another potential signal competing for your attention. That does not mean everything must be perfectly organized before you can begin (while some of us would prefer to work this way), perfection can become its own form of interference. Just get started. It simply means that when you reduce unnecessary visual and mental competition, you make it easier for the brain to recognize the priority in front of you. Clear the space. Name the target. Create the relevance. Then give the task your full attention. Lesson 3: Attention Is Necessary—but It Is Not Enough Paying attention to information once does not guarantee that it will be remembered. This is where Dr. Medina's memory rules enter: Repeat to remember. Remember to repeat. The first refers to giving new information more than one opportunity to be encoded. The second points toward revisiting information over time. This allows you to extend the Movement Loop: Movement prepares the brain and body. Attention selects what to focus on. Retrieval and Repetition strengthens our focus. Recovery helps us to integrate what we are learning. PUT THIS INTO ACTION After learning something new, do not immediately reread it. First, look away from the material and try to retrieve it. Ask yourself: “What were the three most important ideas?” “How would I explain this without looking at my notes?” “What can I remember on my own?” Retrieval reveals the difference between recognizing information and actually being able to access it. Then return to the material, check what you missed, and retrieve it again later—after an hour, the next day, or several days afterward. For students, this could mean closing the textbook and explaining the lesson to a partner. For professionals, it could mean summarizing a meeting before reviewing the notes. For personal learning, it could mean recording a short voice memo explaining the idea from memory. Your experiment is: Learn it once, retrieve it without looking, and schedule a brief return to it later. See if you can remember it. Attention begins the pathway. Retrieval and repetition help strengthen it. Andrea's Application This lesson reminded me of one part of the cognitive testing that accompanied my brain scan at Amen Clinics: a Continuous Performance Test, or CPT. In the version I completed, letters appeared on a computer screen. The instruction was to press a button whenever a letter appeared—except when the letter was X. This type of task may sound simple, but it requires you to remain attentive over time, respond consistently, and inhibit your automatic response when the target letter appears. My results indicated that this was an area in which I did not perform as strongly. Looking back, I remember hearing the basic instruction: press the button for every letter except X. But I do not remember fully appreciating that the speed and consistency of my responses also mattered. This gave me an important real-life lesson: Hearing an instruction is not the same as accurately encoding everything the task requires. Before beginning something important, pause and ask: “What exactly am I being asked to do?” “What details determine successful performance?” “Can I explain the instructions back in my own words?” And, when appropriate, write down the key steps before beginning. This applies in a classroom, during a meeting, while completing an assessment, or whenever accuracy matters. First, attend to the full instruction. Then restate or retrieve it. Clarify anything that is missing. And only then begin the task. My experience showed me that attention is not just about working harder or concentrating more intensely. It is also about identifying the correct target—and making sure we understand the complete task before directing our effort toward it. Lesson 4: Learning Becomes Stronger When It Has More Than One Path Dr. Medina's Brain Rule #9 about sensory integration and vision(meaning our brains learn and remember best when multiple senses—like sight, sound, and touch—are engaged at the same time) give you the practical learning background to involve ALL of your senses. While teaching and learning you can ask: Can I see it? Can I hear it? Can I explain it? Can I demonstrate it? Can I connect it to something I already know? Can I apply it physically or practically? The goal is not sensory stimulation for its own sake. It is to provide clear, relevant pathways through which the learner can interact with the information. Our Key lesson: The more meaningfully we interact with information that we are learning, the more opportunities the brain has to encode and retrieve it. PUT THIS INTO ACTION Choose one idea you want to remember and interact with it in at least two meaningful ways. You might: See it in a diagram. Hear it explained. Say it in your own words. Write or draw it. Teach it to someone else. Demonstrate it physically. Connect it to a previous experience. Or apply it to a real problem. The goal is not to add noise or stimulation. More input is not automatically better. Each interaction should make the idea clearer, more relevant, or easier to retrieve. For example, instead of only reading about the Movement Loop, you could draw the sequence, explain it aloud, and identify where it appears in your own daily routine. Your experiment is: Take one important idea and represent it in two different, meaningful ways. The more deeply we work with information, the more opportunities the brain has to encode and retrieve it. Andrea's Application If you have been listening to this podcast for a while, I'm sure you have noticed that when I organize an idea into a framework—or represent it in a visual graphic—it begins to come to life. I can see how the pieces from past episodes connect, can explain the concept more clearly, and retrieve and apply it to my life more easily. It's also difficult to forget something when there's a visual image connected to it if you are the type of learner who needs to see something to make it stick in your memory. LESSON 5: RECOVERY HELPS LEARNING CONTINUE AFTER ATTENTION ENDS So far, we have followed learning through four important steps: Movement prepares the brain and body. RAS helps “turn on the lights,” allowing us to become awake, alert, and ready to respond. Next, the brain begins identifying what might be important to us. Salience refers to something that stands out—perhaps because it is new, unexpected, emotional, or connected to a possible reward or threat. Relevance refers to how closely that information connects to our goals, needs, experiences, or interests. In simple terms: Salience asks, “What stands out?” Relevance asks, “What matters to me?” Attention through the RAS next directs the brain's spotlight toward the information selected for deeper processing. Imagine a flashlight shining on whatever it is that you have picked to be important to learn. Encoding creates the initial memory. Retrieval and repetition strengthen it. But learning does not necessarily end when we close the book, leave the classroom, finish the meeting, or stop practicing. The brain still needs time to stabilize, organize, and connect what we learned. This is where recovery and sleep enter the Movement Loop. SLEEP IS AN IMPORTANT PART OF LEARNING Sleep is not a period when the brain simply switches off. While we sleep, the brain continues processing information from the day. Newly encoded memories may be reactivated, strengthened, reorganized, and connected with knowledge we already have. This is called memory consolidation. In simple terms, consolidation helps make a new memory more stable and easier to access later. Deep non-REM sleep and REM sleep may support different but overlapping parts of this process. Deep sleep is associated with physical restoration and the consolidation of certain facts and experiences. REM sleep has been associated with emotional learning, procedural skills, creative connections, and integrating new experiences with older memories. But we should not think of these as completely separate jobs. Deep sleep and REM are parts of a repeating sleep cycle, and both may contribute to learning. This is why I use the phrases: Deep sleep helps me recover from the hard work I did that day. REM may help me integrate what I experienced and what it meant to me. The word “may” matters because sleep is more complex than saying that deep sleep only restores the body and REM alone integrates learning. The most important lesson is this: What we focus on while we are awake gives the brain something to work with while we sleep. Retrieval and repetition strengthen the information before sleep. Then sleep provides conditions that can help stabilize, organize, and connect what we learned. THE MOVEMENT LOOP IN SIMPLE TERMS Let's put the complete cognitive side of the Movement Loop into simple language. MOVE—to prepare the brain and body. BECOME READY—RAS- in the brain helps us become awake, alert, and available to respond. NOTICE—salience helps something stand out because it is new, emotional, unexpected, rewarding, or potentially threatening. RELEVANCE—relevance helps the brain recognize how that information relates to our goals, needs, interests, or previous experiences. ATTENTION—directs our mental resources or a spotlight toward the selected information. ENCODE—begins forming a memory of what we are focused on. RETRIEVE AND REPEAT—strengthens the memory and makes it easier to access again. RECOVERY and CONSOLIDATION—so the brain and body can restore, and sleep can support memory consolidation. Leading us to-- INTEGRATION—to connect the new learning with what we already know. APPLY—Making the learning available and ready to use when we need it. So, in its expanded form, the Movement Loop looks like this: Movement → RAS-Supports Readiness → Salience and Relevance (what's important to us)→ Focused Attention → Encoding (forms the memory of what we are focused on)→ Retrieval and Repetition (to strengthen the neural pathway) → Recovery and Consolidation (important for the brain and body to be rested and recovered)→ Integration (connect new learning with what we already know)→ NEW Learning and Performance (ready and available for us whenever we need it). Here is an even easier way to remember how we LEARN: Move. Wake or Get Ready. Notice. Focus. Form a Memory. Strengthen it. Recover it. Connect it. Use it. Movement prepares the system. The RAS helps us become alert. Salience and relevance identify possible priorities. Attention selects the target. Encoding begins the memory. Retrieval and repetition strengthen it. Recovery and sleep help stabilize it. Integration connects it. And application makes it useful. These stages do not always occur in a perfectly straight line. We may notice something before we are fully focused on it. We may need several rounds of encoding and retrieval. We may sleep on an idea and understand it differently the following day. Or we may try to apply what we learned and discover that part of the pathway still needs strengthening. That is why this is a loop rather than a one-way process. Application produces feedback. That feedback shows us what we understand, what we can retrieve and use, and what still requires attention, repetition, or recovery. Then that feedback guides the next cycle of learning. We move again. We become ready. We direct our attention toward what matters. And with each cycle, we build learning that becomes more accessible, adaptable, and useful in our performance. PUT THIS INTO ACTION Before ending your next learning or work session, take one minute to ask: “What is the most important thing I want to remember?” Without looking at your notes, write down the central idea in your own words. Then decide when you will retrieve it again—perhaps later that day or the following morning. After that, give yourself permission to recover. When your attention is fading, another exhausted hour may not be as valuable as a break or a full night of sleep. The following day, try to retrieve the idea again before looking at your notes. Notice what remained accessible and what needs another repetition. Your experiment is simple: Summarize it. Sleep on it. Retrieve it again. Because learning begins while we are awake—but recovery and sleep help the brain continue the work. The Move–Focus–Learn Protocol BRINGING THE FIVE ACTIONS TOGETHER Here is the full Move–Focus–Learn experiment: Test this in school, work or personal learning: Use a brief walk or appropriate movement break before demanding cognitive work. This is what I told Dr. Medina 6 years ago is the only way I'm able to stay focused on writing difficult topics, like this one. Identify the one thing that deserves your attention next. Pick one priority you will focus on. Remove interference. Reduce unnecessary notifications, competing tasks and distractions. This can take a few minutes ahead of time, but keeps the learning slate clean so to speak. Create relevance. Ask, “Why does this matter to me—or to this learner?” Interact with the information you want to learn. Explain it, visualize it, discuss it, demonstrate it or apply it. Retrieve it. Close the book or screen and recall the important ideas without looking. Repeat it later. Return to the information after time has passed. Protect recovery. Allow sleep and recovery to support the next stage of learning. REVIEW AND CONCLUSION As we close out Episode 406, I want to return to the question we began with: Once movement activates and prepares the brain, what determines whether that readiness becomes lasting learning? The answer is not one single process. Learning emerges through a sequence of connected conditions: The brain and body must become ready. Something must stand out and feel relevant. Attention must select it. The information must be encoded. It must be retrieved and revisited. And recovery and sleep must provide opportunities for consolidation and integration. Dr. John Medina's Brain Rules helped us follow this sequence through five key lessons. LESSON 1: EXERCISE PREPARES THE BRAIN Movement helps create biological conditions that support alertness, attention, and cognition. The RAS contributes to this process by helping us become awake, alert, and ready to respond. But movement creates an opportunity—not a guarantee. A prepared brain still needs direction. LESSON 2: ATTENTION SELECTS WHAT MATTERS The brain encounters far more information than it can consciously process. Salience helps us notice what stands out. Relevance connects that information to our goals, needs, interests, or previous experiences. Attention then directs the brain's spotlight toward the selected target. Movement may create greater readiness, but attention determines where that readiness goes. LESSON 3: RETRIEVAL AND REPETITION STRENGTHEN WHAT ATTENTION BEGINS Paying attention once may create familiarity, but familiarity is not the same as learning. Encoding begins the memory. Retrieval asks the brain to locate that information again. Repetition gives us additional opportunities to strengthen our access to it. This is why explaining an idea without looking at our notes can be more useful than simply rereading it. Attention begins the pathway. Retrieval and repetition help make it last. LESSON 4: MEANINGFUL INTERACTION HELPS LEARNING STICK We can strengthen encoding by interacting with an idea in more than one meaningful way. We might see it, hear it, explain it, draw it, demonstrate it, or apply it. The goal is not to add as much stimulation as possible. The goal is to give the brain clear and relevant ways to understand, represent, and later retrieve the information. This is something I have experienced while creating this podcast. When I organize an idea into a framework or bring it to life in a visual graphic, I can see how the pieces connect. That helps me explain the idea more clearly, remember it more easily, and apply it more effectively. LESSON 5: RECOVERY ALLOWS LEARNING TO CONTINUE Learning does not necessarily end when we close the book, leave the classroom, finish the meeting, or stop practicing. During sleep, newly encoded information may be reactivated, stabilized, reorganized, and connected with existing knowledge. Deep non-REM sleep and REM sleep may contribute to this process in different but complementary ways. This is why recovery is not separate from learning. Recovery is part of the learning process. PUTTING THE MOVEMENT LOOP TOGETHER The complete cognitive side of the Movement Loop now looks like this: Movement prepares the brain and body. RAS-supported arousal helps us become awake and alert. Salience and relevance help identify possible priorities. Attention selects the target. Encoding begins the memory. Retrieval and repetition strengthen it. Recovery and sleep support consolidation. Integration connects the new learning with what we already know. And application makes that learning available when we need it. Or, in its simplest form: Move. Wake. Notice. Focus. Form. Strengthen. Recover. Connect. Use. Movement creates readiness. Attention provides direction. Encoding begins the memory. Retrieval and repetition strengthen the pathway. Recovery supports consolidation and integration. And application turns what we have learned into improved performance. Together, these processes help turn activity into lasting learning. FINAL THOUGHT This is not the first time we have explored Dr. John Medina's work, but each return has allowed us to ask a different question. In Episode 42[ix], we asked: How should schools and workplaces change when we understand the brain? In Episode 370[x], we asked: How can neuroscience and emotional regulation improve learning environments? In Episode 395[xi], we asked: What captures attention and motivates behavior? And here in Episode 406, we asked: How does an activated and attentive brain convert an experience into learning? That question has helped us add important detail to the Movement Loop. Movement alone does not create learning. Attention alone does not create lasting memory. Repetition without meaning may not produce understanding. And effort without recovery may not give the brain the conditions it needs to consolidate and integrate what happened. Each part of the process matters. Before we close, consider these questions: What are you preparing your brain to notice? Where is your attention going after you move? Are you interacting with important information deeply enough to encode it? Are you retrieving what you are learning—or merely rereading it? And are you protecting the recovery that allows learning to continue? Because what we repeatedly attend to, retrieve, and apply begins to shape what we know, what we can do, and how we perform. PREPARING FOR EPISODE 407 Movement can prepare the brain. Attention can direct it. Encoding can begin the memory. Retrieval and repetition can strengthen it. And recovery can help consolidate and integrate it. But every part of this process requires energy. The brain needs energy to direct attention, form memories, regulate behavior, and sustain performance. The body needs energy to move, adapt, recover, and begin the cycle again. So in Episode 407, we will revisit Jason Wittrock's work through a more current and carefully defined lens. We'll examine his experience with nutrition and fasting as an applied practitioner and personal case study, while comparing those ideas with current evidence surrounding nutrition, blood-sugar stability, metabolic flexibility, recovery, and performance. Because the brain and body cannot sustain performance without the energy required to power the system. I'll see you next time as we ask: How does metabolic health influence our capacity to move, learn, recover, and perform? RESOURCES Clip 1 with Dr. John Medina https://www.youtube.com/shorts/zDItOHAc8qQ Full Interview with Dr. John Medina https://www.youtube.com/watch?v=CFzg5nQnEMs REFERENCE   [i] John Medina's Brain Rule #4 https://brainrules.net/article/attention/   [ii] Neuroscience Meets Social and Emotional Learning Podcast EPISODE 42 with Dr. John Medina on “Implementing Brain Rules in Schools and Workplaces of the Future” https://andreasamadi.podbean.com/e/dr-john-medina-on-implementing-brain-rules-in-the-schools-and-workplaces-of-the-future/   [iii]Neuroscience Meets Social and Emotional Learning Podcast EPISODE 403 https://andreasamadi.podbean.com/e/movement-first-how-a-20%e2%80%91minute-walk-lights-up-the-brain/     [iv]Neuroscience Meets Social and Emotional Learning Podcast EPISODE 404 https://andreasamadi.podbean.com/e/movement-matters-how-every-move-rewires-the-brain/   [v] Neuroscience Meets Social and Emotional Learning Podcast EPISODE 405 https://andreasamadi.podbean.com/e/movement-isnt-enough-how-recovery-drives-real-adaptation/   [vi]Neuroscience Meets Social and Emotional Learning Podcast EPISODE 272 https://andreasamadi.podbean.com/e/brain-fact-friday-on-priming-the-reticular-activating-system-to-achieve-our-goals-in-2023/   [vii] Neuroscience Meets Social and Emotional Learning Podcast EPISODE 395 https://andreasamadi.podbean.com/e/theory-of-mind-the-missing-link-between-attention-reward-and-motivation/   [viii]Neuroscience Meets Social and Emotional Learning Podcast EPISODE 84  https://andreasamadi.podbean.com/e/how-a-spect-scan-can-change-your-life-part-3-with-andrea-samadi/   [ix] Neuroscience Meets Social and Emotional Learning Podcast EPISODE 42 with Dr. John Medina on “Implementing Brain Rules in Schools and Workplaces of the Future” https://andreasamadi.podbean.com/e/dr-john-medina-on-implementing-brain-rules-in-the-schools-and-workplaces-of-the-future/   [x]Neuroscience Meets Social and Emotional Learning Podcast EPISODE 370 https://andreasamadi.podbean.com/e/brain-rules-revisited-how-neuroscience-can-transform-classrooms/   [xi]Neuroscience Meets Social and Emotional Learning Podcast EPISODE 395 https://andreasamadi.podbean.com/e/theory-of-mind-the-missing-link-between-attention-reward-and-motivation/      

The 2026 Fierce 50 includes people and organizations working on very different problems across biopharma and healthcare, from designing new proteins and developing cancer medicines to protecting vaccine science, improving health literacy and expanding representation in medicine. In this episode of “The Top Line,” Fierce Editor-in-Chief Ayla Ellison looks at the stories behind several of this year’s honorees, including Revolution Medicines’ work targeting RAS, the protein-design research of David Baker, Ph.D., and Michael Osterholm, Ph.D.’s, decision to put plans to step back from public health on hold. The episode also explores the work of Lisa Fitzpatrick, M.D., Hip Hop Public Health, Eric Topol, M.D., and Mary Owen, M.D., and the problems they have chosen to keep working on.See omnystudio.com/listener for privacy information.

PARADIGM is finally published, so we have more details from this study presented at ASH about HMA/Ven vs. Intensive Chemo if fit patients with AML. Daraxonrasib looks like a promising drug for RAS-mutant NSCLC, too. Download the Oncology Learning Companion: https://www.kelleycpharmd.com/learning-oncology-companion-oncopharm

On Ron's Amazing Stories this week, things get a little strange. Okay... maybe more than a little. We're bringing back an old RAS favorite, As Read By, with listener Franklin Paul taking us straight into the pages of a 1950s science-fiction pulp magazine. Then, on The RAS Signal, we turn our attention to one of the greatest voices of old-time radio — Agnes Moorehead. And since we're talking about Moorehead, why not hear her in action? We'll finish with a classic episode of Suspense where a simple chain letter sets off a very unfortunate… chain of events. In This Episode As Read By Returns — An old RAS segment is back, featuring stories straight from the pulp magazines. The RAS Signal: Agnes Moorehead — We look at the life and remarkable radio career of the woman behind one of old-time radio's most unforgettable voices. Martian V.F.W. — Listener Franklin Paul reads a wonderfully strange science-fiction tale from 1959. The Chain — Agnes Moorehead and William Conrad star in a psychological thriller from the series Suspense. Featured Stories Martian V.F.W. From the May 1959 issue of Amazing Science Fiction Stories, written by G. L. Vandenburg and read by listener Franklin Paul. A parade celebrating the International Geophysical Year already has floats, bands, rockets, and displays of life on other planets. Then the parade manager is approached by a six-foot-tall ant claiming to represent the Martian V.F.W. Who are these strange visitors... and what do they really want? The Chain Suspense — Originally broadcast March 9, 1958. Agnes Moorehead stars as a vindictive woman whose decision to send a superstitious chain letter to an immigrant neighbor's wife begins a sequence of events that quickly spirals beyond her control. William Conrad also appears as Lieutenant Marsh. It's superstition, fear, and unintended consequences in a story that proves sometimes it's better to just throw the darn letter away. Ron's Amazing Stories Is Sponsored by: Audible - You can get a free audiobook and a 30 day free trial at audibletrial.com/ronsamazingstories. Your Stories: Do you have a story that you would like to share on the podcast or the blog? Head to the main website, click on Story Submission, leave your story, give it a title, and please tell me where you're from. I will read it if I can. Links are below. Music Used In This Podcast: Most of the music you hear on Ron's Amazing Stories has been composed by Kevin MacLeod (incompetech.com) and is Licensed under Creative Commons: By Attribution 3.0. Other pieces are in the public domain. You can find great free music at FreePd.com which is a site owned by Kevin. Program Info: Ron's Amazing Stories is published each Thursday. You can download it from Apple Podcasts, stream it on YouTube or on the mobile version of Spotify. Do you prefer the radio? We are heard every Thursday at 10:00 pm and Sunday Night at 11:00 PM (EST) on AMFM247.COM. Check your local listing or find the station closest to you at this link. Social Links: Main Podcast Site by LibSynThe Blog Site by WordPressFacebook LinkTwitter Link Contact Links: EmailStory Submissions Contact Ron

This episode highlights FDA approval of the first-in-class RAS inhibitor daraxonrasib for metastatic pancreatic adenocarcinoma, concerning gaps in cervical cancer screening and HPV vaccination among younger women, and new evidence defining which patients may benefit most from coronary artery calcium scoring alongside the PREVENT cardiovascular risk calculator.

This one is all about the last four months of the year, and why we do not have to wait for January to start creating change.Today's episode is a solo one, and I've done my journaling, my research and a whole lot of thinking to bring you five powerful ways to change your life before the year is done. September is here, summer is coming, Christmas is on the way, and I want us to use this next stretch of the year so that when we sit down with our journals between Christmas and New Year, we are so proud of how far we've come.I get really honest about where I'm at with all of this myself, including the FitSpo couple training mornings Luke and I have just started (completely out of my comfort zone), and the Australia-wide tour I wrote down as a goal for six years before I finally did it this year.In this episode, I talk about:~ Why the last few months of the year matter just as much as January 1st ~ The five powerful ways to change your life before the year is done. (They aren't your usual, get up earlier, make your bed etc. We get deeper & more woo-woo than this! ~ The story of the impulse that became Pass Around the Smile, and why I almost didn't listen to it ~ The reticular activating system (RAS) and how to prove to your brain that the life you want is already yours ~ My slightly unhinged driveway manifestation ritual (you'll understand when you hear it) ~ Why you don't need to fake positivity, you just need to stop repeating the old story ~ Three tasks to take with you this week: notice the signs, leave space to be surprised, and make one decision your future self would thank you forThank you to Brittany from With Purpose Fitness and Confidence Coaching for sponsoring this episode!You can find her links below.Visit With Purpose Fitness and Confidence Coaching website here! Visit Brittany's Instagram here! Grab your tickets to the With Purpose x Pass Around the Smile event here!Cleo's links below ⁠Visit Pass Around the Smile here!⁠⁠⁠⁠⁠⁠Join my Facebook community group here!⁠⁠⁠Find me on Instagram⁠⁠⁠@passaroundthesmile⁠⁠⁠⁠⁠⁠@cleomassey⁠⁠⁠Find me on Tik Tok⁠⁠⁠@cleomassey_⁠⁠⁠The Pass Around the Smile podcast is recorded on Bundjalung Country, in South East Queensland, Australia. We acknowledge the Yugambeh people of the Bundjalung Nation, the traditional owners of this land. We pay our respects to Elders past, present and emerging.

This week, we feature new research on acute myeloid leukemia, achondroplasia, pediatric septic shock, and RAS-mutant lung cancer. We also review the evaluation and management of pulmonary nodules and follow a diagnostic case of recurrent fractures. Perspectives explore reproductive health care, the human–animal bond in health care access, and on creating space for patients' voices in clinical decision making.

A powerful way to start your day is to enter a theta brainwave state to reprogram your mind for manifesting. This guided meditation will work with your RAS in your brain to help filter reality to look for the opportunities to help you grow and expand your success. Make this a daily practise to rewire your brain for the success and happiness you dream of."I wonder what miraculous opportunities you will notice coming your way today?"Let me know what happens for you in the comments.New meditations and hypnosis sessions coming soon.About Paul Sheppard My work began with my own experience of anxiety. When traditional approaches failed to provide the change I needed, I trained in new methods and developed a process that transformed my life. Since then, I've coached hundreds of clients to feel less anxious, more empowered and more in control.Today, I help professionals become calmer, more confident and better equipped to perform at their best. My neuroscience-backed approach is designed to create meaningful change that lasts.My coaching goes beyond surface-level mindset work. It helps you recognise the fear-based patterns of the ego, reconnect with who you really are and create meaningful change from within.Life is too short to let old patterns hold you back.ON THIS CHANNELYou'll find podcast conversations, guided breath work, meditations and practical insights to support inner transformation.EXPERIENCE AND CREDENTIALS• Over 20 years' experience• ICF-certified coach• GHR-registered therapist• Host of the top ten Ultimate Mindset Change Podcast (143 Countries)• Trained with Patrick McKeown's Oxygen Advantage® team• Author of Anxiety Is Your Wake-Up CallContact me Mindset Change Updates NewsletterInstagram @MindsetchangeukFacebook Tik Tok Community Mentioned in this episode:Ego Algorithm Coaching Details.Instagram @mindsetchangeuk Email: Info@mindsetchangeuk.com   I hope you got to enjoy that meditation. It's incredible what's available to you with regular practice. And here's something that I wanted to draw your attention to. If you're a coach or you're a business owner who's in the fitness and wellbeing space, and you want to have more impact but less anxiety, less stress, and self-doubt in 90 days, then please direct message me on Instagram the word ego or use the contact link below in the show notes. I look forward to hearing from you

Auto-generated transcript: Bismillāh ar-Raḥmān ar-Raḥīm. Alḥamdulillāhi Rabbil ‘Alāmīn. Wa salātu wa salāmu ‘alā ash-sharafi al-anbiyā’ wal-mursalīn, Muḥammadur Rasūlullāh ﷺ. Rasūlullāh kathīra kathīra. My brother and sister, Allāh subḥānahu wa ta’ālā comes under us and said: “Yā ayyuhal-ladhīna āmanū, wata’simū bihawli Allāhi jami’an, wa la tafarraqū.” Allāh subḥānahu wa ta’ālā said, “Hold together firmly to the… Continue reading Become beneficial

What if your brain is filtering your life for evidence that you’re failing, without you even realising it? In this episode, Dr Lucy and Dr Mary explore the reticular activating system, or RAS, and how this powerful brain filter can shape your mindset, habits, and momentum. Think of it like your social media algorithm: what you pay attention to, your brain is more likely to show you again. That can leave you noticing every mistake, feeding all-or-nothing thinking, and asking, “What’s the point?” But with awareness and intention, you can begin to direct your focus towards the small actions, opportunities, and evidence that support the life you want to build. Dr Lucy also shares a candid personal experience of recognising an unhelpful spiral and recommitting to the habits that help her feel better. You’ll hear practical ways to use specific goals, visualisation, self-care, and positive attention to help your brain work with you, not against you. This isn’t about pretending life is perfect. It’s about choosing where you place your attention, one realistic step at a time. For more information about Real Life Medicine and our programs and special offers: https://www.rlmedicine.com/ Episode, show notes & transcript https://www.rlmedicine.com/stuck-in-a-negative-spiral-start-here See omnystudio.com/listener for privacy information.

Watertown Whiskey Presents Reality After Show's Fantasy Football Draft join Survivor legend Jonny FairPlay and Producer Bobby Goodsby as they preview each week of the NFL Season. Tune in each week as Celebrity guests join them to discuss the NFL's hottest topics and conversations of the week! Special thanks to the best Whiskey on the Planet Watertown Whiskey! Check them out on instagram: https://www.instagram/watertownwhiskey Tell them Fairplay sent you! Please Drink Responsibly https://watertownwhiskey.comCheck out the ALL NEW RealityAfterShow.com official website! Episode links available at RealityPatron.comJoin Jonny LIVE SurvivorTix.com#NFL #podcast #football #survivor #realitytv #realityaftershow #NFLNews #vikings #packers #cowboys #chiefs #packers #browns #broncos #ravens #chargers    / @aftershow   Arizona Cardinals, Atlanta Falcons, Baltimore Ravens, Buffalo Bills, Carolina Panthers, Chicago Bears, Cincinnati Bengals, Cleveland Browns, Dallas Cowboys, Denver Broncos, Detroit Lions, Green Bay Packers, Houston Texans, Indianapolis Colts, Jacksonville Jaguars, Kansas City Chiefs, Las Vegas Raiders, Los Angeles Chargers, Los Angeles Rams, Miami Dolphins, Minnesota Vikings, New England Patriots, New Orleans Saints, New York Giants, New York Jets, Philadelphia Eagles, Pittsburgh Steelers, San Francisco 49ers, Seattle Seahawks, Tampa Bay Buccaneers, Tennessee Titans, Washington Commanders

Como a inibição da via RAS no câncer de pâncreas, as formulações orais para controle glicometabólico e os LLMs no fluxo cirúrgico impactam a prática médica? Neste episódio do Afya News, analisamos a aprovação concedida pela FDA ao daraxonrasib, novo tratamento oral que reduziu em 60% o risco de morte e dobrou a sobrevida mediana de adultos com adenocarcinoma de pâncreas metastático. Discutimos também a estreia do orforglipron (Foundayo) no Reino Unido, trazendo uma opção oral diária de agonista do receptor de GLP-1 para o manejo de diabetes tipo 2 e perda de peso. Por fim, apresentamos no Radar a pesquisa do JAMA Network Open sobre a integração de modelos de linguagem diretamente ao prontuário eletrônico para otimizar a triagem no cuidado perioperatório. O Afya News apresenta notícias da medicina com informação confiável e atualizada no seu tempo. Criado pela Afya, o maior hub de educação e soluções para a prática médica do Brasil, nosso propósito é transformar a saúde junto com quem tem a medicina como vocação.Fontes do episódio aqui:⁠https://portal.afya.com.br/podcasts/afya-news/28-08-2026Conteúdo 100% validado por equipe médica.Médico Responsável: Dr. Guilherme Rodrigues — CRM-RJ 1049461.

Good morning from Pharma Daily: the podcast that brings you the most important developments in the pharmaceutical and biotech world. Today, we explore groundbreaking advancements, regulatory updates, and strategic partnerships shaping the future of patient care and drug development. Revolution Medicines has achieved a significant milestone with the FDA approval of its RAS inhibitor, daraxonrasib, for metastatic pancreatic cancer treatment. This approval follows an impressive presentation at the American Society of Clinical Oncology meeting that garnered widespread acclaim. Targeting one of the most challenging cancers, this advancement offers renewed hope for patients with limited treatment options and sets a potential new standard in pancreatic cancer therapy. In another promising development, Amgen and AstraZeneca have successfully completed a Phase 3 trial for their drug Tezspire in eosinophilic esophagitis. This success positions Tezspire as a formidable contender in the competitive landscape of inflammatory disease treatments, directly challenging Sanofi and Regeneron's Dupixent. The focus on biologics targeting specific inflammatory pathways underscores ongoing innovation in this area, offering enhanced treatment options for patients. On the regulatory front, the FDA has expanded its authorization for Tivicay, an HIV medication, to include newborns. This move aligns with global efforts to advance pediatric HIV treatment and address public health challenges. Additionally, Roche has secured further FDA approval for diagnostic tests linked to Jazz Pharmaceuticals' oncology drug Ziihera, emphasizing the critical role of companion diagnostics in personalized medicine. Meanwhile, strategic initiatives are also taking shape in pricing agreements. The Trump administration is preparing to announce "most favored nation" pricing agreements with mid-sized biopharma companies as part of ongoing efforts to tackle drug pricing issues. Although these arrangements could lead to lower drug prices, they may also face industry resistance due to potential impacts on revenue. Flagship Pioneering's Profound Therapeutics has partnered with the Gates Foundation in a $35 million effort to discover new drug targets for preeclampsia—a dangerous pregnancy complication. Such collaborations are vital in accelerating research and offering innovative solutions to complex health problems. Artis Biosolutions is expanding its synthetic DNA and mRNA production capabilities with a new facility in Spain. This development highlights the growing importance of genetic medicines and reflects an industry shift towards next-generation therapies like gene editing and RNA-based treatments. On a global scale, CEPI is supporting Minapharm's Ebola vaccine candidate advancement into clinical trials amid a growing outbreak. This initiative is part of a broader strategy to enhance epidemic preparedness through rapid vaccine development and deployment. Another significant move comes from McKesson's $2.25 billion acquisition of Precision Medicine Group. This acquisition aims to strengthen McKesson's oncology and biopharma segments, emphasizing precision medicine's growing role in personalized cancer treatment. In the context of geopolitical dynamics, concerns about Chinese dominance in clinical trials and supply chains have been raised by Congressman Nathaniel Moran. This highlights strategic dependencies and underscores the need for robust domestic capabilities in biopharmaceutical research and manufacturing. In clinical developments, Bausch + Lomb faced setbacks with its phase 2 trial combining dry-eye disease drugs Xiidra and Miebo but remains optimistic as it advances to phase 3 trials. Conversely, Spyre Therapeutics is deprioritizing its anti-TL1A antibody approach following underwhelming phase 2 results for rheumatoid arthritis—a testament to the rigorous validation process required before new therapies can reach patients. Akeso's success with its PD-1xVEGF bispecific antibody ivonescimab in biliary tract cancer demonstrates innovative biologics' potential to expand treatment options beyond traditional indications. In regulatory news concerning Capricor Therapeutics' Duchenne muscular dystrophy therapy, an extended FDA review period reflects careful regulatory evaluation following additional data submissions. These developments paint a picture of a dynamic landscape where scientific innovation is paralleled by regulatory challenges and strategic partnerships aimed at addressing both market demands and pressing health issues. The continued focus on personalized medicine, competitive dynamics in biologics, and global collaboration efforts underscores a transformative period for pharmaceuticals and biotech industries. As these sectors evolve, they hold the promise of delivering more effective treatments worldwide while addressing unmet medical needs across various domains.Support the show

This week on Circle Back, host Jacob Gramegna is joined by Porter, Isaac Rose-Berman, and Shipper to break down three stories shaking up the prediction markets and sports betting world. The crew dives into a New York Times report that Donald Trump Jr. privately urged a room of Republican state attorneys general to back off regulating prediction markets, arguing that state pushback was being driven by gambling companies protecting their own turf rather than genuine consumer concerns. The panel unpacks what this closed-door pitch means for the ongoing battle between state and federal oversight of the industry, and why prediction markets have become such a political flashpoint heading into the fall. From there, the conversation shifts to a major shift in how prediction markets present their pricing, as platforms move away from familiar American-odds formatting toward straight percentages, a change that's got bettors adjusting their mental math and wondering if more platforms will follow. The show wraps with a look at sharp originators pulling their models and ratings out of public view, as some of the most respected names in the space decide their edge is too valuable to keep sharing for free, and what that shift could mean for bettors who've relied on that public data for years. This episode also marks the final edition of Circle Back Thursday. After more than a year on the air, this is the last time the show will run in this Thursday slot, though Circle Back Monday continues as normal and new content is on the way to fill the Friday spot.

Good morning from Pharma Daily: the podcast that brings you the most important developments in the pharmaceutical and biotech world. Let's dive right into today's top stories, where pioneering advancements and strategic shifts are reshaping how we understand and treat complex diseases. In recent developments, Akeso's PD-1xVEGF bispecific antibody ivonescimab is making waves beyond its initial use in non-small cell lung cancer. The successful completion of a Phase 3 trial for biliary tract cancer marks a pivotal moment, suggesting broader applications of this dual-targeting therapy. Ivonescimab's mechanism—enhancing immune response while inhibiting tumor angiogenesis—could significantly improve patient outcomes across various cancers. However, questions about its efficacy continue to prompt careful scrutiny as it challenges existing treatment paradigms. Regulatory dynamics are equally compelling, with the FDA undergoing potential restructuring under President Trump's nominee for commissioner. The creation of two new deputy commissioner roles is speculated to enhance oversight and accelerate drug approval processes. Such changes are crucial as the FDA navigates increasing demands for rapid evaluations amidst complex pharmaceutical landscapes. Meanwhile, Teva Pharmaceutical Industries finds itself under a competition probe in Turkey, highlighting global antitrust challenges within the industry. As Teva juggles its dual role as a generics leader and an innovator, this scrutiny underscores the delicate balance of maintaining market dominance while adhering to fair competition laws. On the safety front, Baxter International has initiated recalls of two medical products due to particulate contamination concerns. This action underscores the critical importance of rigorous quality control in safeguarding patient trust and safety. Similarly, Vitruvias Therapeutics has recalled thyroid tablets labeled "superpotent," emphasizing precision's vital role in pharmaceutical manufacturing. Eli Lilly is expanding its focus on obesity treatment through Medicare access campaigns for GLP-1 receptor agonists. By targeting older adults, Lilly aims to address obesity as a chronic condition requiring sustained intervention, potentially enhancing health outcomes for millions. Public health remains a pressing concern as Pennsylvania reports its first measles-associated deaths in decades amid rising nationwide cases. This situation highlights the ongoing need for robust vaccination campaigns and public health strategies to combat vaccine-preventable diseases effectively. Cybersecurity is also at the forefront, with Boston Scientific experiencing disruptions from a cyberattack. This incident reflects a broader trend affecting medtech firms globally, underscoring the necessity for robust cybersecurity measures to protect sensitive data and ensure uninterrupted healthcare services. Strategic collaborations continue to drive innovation. SK Biopharmaceuticals' $795 million deal with Biohaven Pharmaceuticals aims to accelerate epilepsy therapy development targeting KV7 ion channels. Such partnerships exemplify how strategic investments can expedite drug development timelines and bring promising therapies to market faster. LabCorp's launch of a new hepatitis D test represents an advancement in diagnostic capabilities, aiming to identify patients with severe viral infections earlier, potentially leading to more timely interventions and better management of complications. Shifting our focus back to oncology, Revolution Medicines has achieved FDA approval for daraxonrasib, a RAS inhibitor targeting metastatic pancreatic cancer. With compelling data presented at ASCO, this approval signifies a breakthrough in treating RAS mutations—a challenging target implicated in many cancers. The drug's direct inhibition of mutated KRAS proteins disrupts cancer cell proliferation pathways considered "undruggable" until now. The implications are profound: daraxonrasib not only offers hope to patients with limited options but also sets new benchmarks for future RAS-targeted therapy development. It highlights precision medicine's growing trend—tailoring treatments based on genetic profiles to enhance effectiveness while minimizing side effects. In another significant advancement, Jazz Pharmaceuticals' Ziihera (zanidatamab) has been approved by the FDA as a first-line HER2-targeted therapy for gastroesophageal adenocarcinoma. This bispecific antibody represents a promising new class of treatment, enhancing options for patients with this aggressive cancer type and underscoring personalized medicine's importance in oncology. As we conclude today's update, these developments showcase how scientific breakthroughs, regulatory adaptations, and strategic collaborations collectively shape the future landscape of drug development and patient care globally. The industry remains dynamic as it navigates complexities while striving for innovative solutions that promise better health outcomes across diverse medical conditions. Stay tuned for more updates on Pharma Daily as we continue bringing you insights into the ever-evolving world of pharmaceuticals and biotechnology.Support the show

What if the goals you're chasing aren't out of reach—you just haven't trained your mind to recognize the path to them yet? In this episode of the 365 Driven Podcast, host Tony Whatley explores the power of visualization and why creating a clear picture of your future can influence the opportunities you notice, the decisions you make, and the actions you take. But this isn't about simply wishing for success. Tony explains why visualization only becomes powerful when it's paired with consistent action, patience, and the willingness to keep moving forward when results aren't immediate. Drawing from his own life, Tony shares how vision boards have been part of his mindset since childhood and tells the stories behind goals that took more than a decade to become reality—including owning the exact types of dream cars he once pictured when they seemed financially impossible. He also breaks down the concept of the Reticular Activating System (RAS) and how setting specific goals can help you become more aware of opportunities, people, information, and resources that may move you closer to what you want. For entrepreneurs, Tony takes the conversation even deeper by introducing the idea of "significance value." Business owners are constantly forced to prioritize what is urgent and important, but some of the most transformational work you can do today may not produce results for months—or even years. Tony uses his own bestselling book as an example of how completing something that wasn't necessarily urgent ultimately changed the trajectory of his career, opening doors to stages, interviews, coaching opportunities, and greater influence. This episode is a reminder that entrepreneurship is a long game. The actions you take today may seem small, but when you combine a clear vision with relentless consistency, those actions compound. Five or ten years will pass either way—the question is who you'll become and what you'll have built when you get there. Key Highlights: The power of visualization in achieving goals How vision boards keep goals top of mind Using your RAS to recognize opportunities Why visualization must be paired with action The importance of consistency and patience Understanding the "significance value" of your work Why most people quit too soon How small daily actions create long-term success Connect with Tony Whatley: Website: 365driven.com Instagram: @365driven Facebook: 365 Driven

GLP-1 receptor agonists are one of the most revolutionary new classes of drugs in decades. In this episode of Healthy Dialogue, host Derek C. Angus, MD, MPH, sat down with Jens Juul Holst, MD, DMSc, and Lotte Bjerre Knudsen, DMSc, 2 pioneering scientists behind the discovery and development of GLP-1 RAs. Together, they traced the fascinating origin story of GLP-1 RAs and offered their thoughts on what comes next. Related Content: GLP-1s—From Gut Hormone Discovery to a Public Health Revolution

Auto-generated transcript: Bismillāh ar-Raḥmān ar-Raḥīm. Al-Ḥamdu lillāhi Rabbil-‘Ālamīn, wa salātu wa salāmu ‘alā ash-sharafi al-anbiyā’ wal-mursalīn: Muḥammadur Rasūlullāh ﷺ, wa ‘alā ālihi wa sahbihi wa sallam. Taslimun dhikrun wa dhikrun. And after that, my brothers and sisters, Allāh Subḥānahu wa Ta’ālā began His words with the word of praise, the word of shukr, the word… Continue reading Begin with thanks

Auto-generated transcript: Bismillāh ar-Raḥmān ar-Raḥīm. Al-Ḥamdu lillāhi Rabbil-‘Ālamīn. Wa salātu wa salāmu ‘alā ash-sharafi al-anbiyā’ wal-mursalīn, Muḥammadun Rasūlullāh ﷺ, wa ‘alā ālihi wa sahbihi wa sallam. Tasliman kathīran kathirahum ‘abadhu. My brothers and sisters, Allah subḥānahu wa ta’ālā said: “Inna Allāha ma’a alladhīna ittaqaw wal-ladhīna hum muhsinūn.” (inna lillahi wa inna ilayhi raji’un). Allah subḥānahu… Continue reading Ambition is to be a Muttaqi

Part 2! Dr. Eric Jaffe returns to actually treat the cancer this time: why radiation is basically catching your kid smoking and making him finish the carton, how CRISPR turns your own T cells into an assassin squad, and why oncolytic viruses are just Jurassic World Dominion for tumors. Haven't heard Part 1 yet? Start there or you'll be lost. Mentioned: CAR-T therapy RAS inhibitor drugs Oncolytic viruses mRNA cancer vaccines Red Queen hypothesis Cancer-sniffing dogs Are you an expert in something and want to be on the show? Apply here! Please support the show on Patreon! You get ad-free episodes, early episodes, and other bonus content! https://www.patreon.com/seriouspod