Podcasts about Antibiotic

Send us Fan MailIs five days of antibiotics enough to treat a urinary tract infection in a NICU infant? In this Journal Club episode, Ben and Daphna review a single-center study from Nationwide Children's Hospital examining adherence and safety of a five-day antibiotic treatment guideline for culture and urinalysis-proven UTIs in the NICU. Among 77 infants with 93 bacterial UTIs, the five-day course was associated with a 1% failure rate, defined as reinitiation of antibiotics within seven days for the same organism. The episode also explores the potential role of enteral antibiotic therapy and what shorter treatment courses could mean for babies still weeks away from discharge.----Urinary tract infection in the neonatal intensive care unit. Magers J, Burton A, Prusakov P, White NO, Miller RR, Moraille R, Theile AR, Sánchez PJ; Nationwide Children's Hospital Neonatal Antimicrobial Stewardship Program (NEO-ASP).J Perinatol. 2026 May;46(5):754-760. doi: 10.1038/s41372-026-02690-1. Epub 2026 Apr 29.PMID: 42056240 Free PMC article.Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!

Fishhook injuries are common, surprisingly nuanced, and honestly a little intimidating until you've removed a few. In this first episode of our Minor Procedures series, we'll reel in the essentials of pediatric fishhook removal, helping you take the bait on four classic removal techniques, procedural planning, anesthesia strategies, and post-removal management. We'll discuss when to pull back, when to advance, when not to get hooked on a single technique, and how to avoid turning a simple procedure into the one that got away. Along the way we'll cover sedation, antibiotics, wound care, and practical pearls to help you land these cases with confidence. Learning Objectives Compare and select among the four major fishhook removal techniques based on hook characteristics, depth of penetration, and anatomic location. Apply evidence-based approaches to analgesia, anxiolysis, procedural sedation, and post-removal management for pediatric fishhook injuries. Identify situations requiring escalation of care, including ocular involvement, contaminated water exposure, tendon or joint involvement, and circumstances where routine management may not be sufficient. References Gammons MG, Jackson E. Fishhook removal. Am Fam Physician. 2001;63(11):2231-2236. Prats M, O'Connell M, Wellock A, Kman NE. Fishhook removal: case reports and a review of the literature. J Emerg Med. 2013;44(6):e375-e380. doi:10.1016/j.jemermed.2012.11.058 Doser C, Cooper WL, Ediger WM, et al. Fishhook injuries: a prospective evaluation. Am J Emerg Med. 1991;9(5):413-415. doi:10.1016/0735-6757(91)90204-w Transcript This episode used an AI-generated transcript created in Descript as an initial draft. The transcript was subsequently edited, expanded, and refined by the author with assistance from OpenAI's ChatGPT (GPT-5.5). Final editorial decisions and content responsibility remain with the author. Welcome to PEM Currents: The Pediatric Emergency Medicine Podcast. As always, I'm your host, Brad Sobolewski, and today we're gonna start a new series on minor procedures. These are the types of procedures that we perform all the time in the emergency department. They're not the subject of multicenter trials or big keynote lectures, but these are the things that patients and families remember, and trust me, they will remember them whether you do them well or not. First up, fishhook removal. So I'm hoping to reel in some listeners with this one, and so hopefully you'll take the bait, and by the end of this episode you'll understand exactly what angle I'm coming from. And hopefully I'm just not trying to make a bass of myself. So anyway, fishhook removal sounds really simple until you actually start doing it. There's not just one technique. There are four classic approaches, and I'll talk about them all, and which one you choose depends on the hook, whether there's a barb, how deep it is, where it's located, your personal experience with different techniques. Fishhook injuries in children are usually minor and most commonly involve the hands and head, though I've seen them stuck in other body parts as well. Most can be managed in the emergency department or urgent care setting with local anesthesia and basic equipment Of course, if there's concern for tendon involvement, joint penetration, neurovascular compromise, if it's anywhere near the eyeball, you should stop and rethink your plan. You know, so ortho, if it's embedded deeply in a joint, um, anything that involves the eye itself isn't necessarily an emergency department procedure, and I'm not talking about the eyebrow, I'm talking about the globe. Fortunately, that's very rare, but that's definitely an ophthalmology conversation. And so before you even think about removing, you need to understand the hook. Is this a single hook or is this a treble hook? A treble hook is a type of fishing hook that has three individual hooks and barbs arranged in a triangular formation, and they're all fused to a single shank and eye. The eye is where the line gets tied to the hook. Is it freshwater or saltwater? How long has it been there? Is it an old rusty one that was sitting in your garage? Was it underwater for a few hours and then it got hooked in the skin? And honestly, how cooperative is the kid gonna be? Because unlike actual fishing, this is one of the procedures where patience beats blunt force. So the simplest technique is retrograde removal. This is exactly what families think you're gonna do before you walk in the room. You know, just pull it out the way it went in. But that's not how hooks are designed. They have the barb. They're designed to stay in the fish. So most of the hooks that I've removed are barbed hooks, and so you can't just back them out. If you try to pull a hook out the way it came in, it's gonna catch and tug on the tissue, it's gonna lead to more pain, bleeding and tissue distortion and not really gonna get you anywhere. So just pulling it out doesn't work, and family probably would have already tried that at home. The technique I end up using most often is advance and cut. And it kind of sounds wrong the first time you explain it to a family because your solution to removing the hook is to continue to advance the hook, but mechanically, this makes the most sense. So you advance the point of the hook through the skin until the barb exits completely, then use either really good trauma shears or heavy wire cutters to cut the hook in between the shank and the barb. If it's in a location where you have, uh, enough room, I like to hold a hemostat real close to the skin, grabbing the hook. Then I cut near the barb, get the pointy part out of the way, remove the hemostats, and then back it through the skin. This is considered the most reliable technique, and in most reviews it's described as being nearly universally successful, even for larger hooks. In children, I think this needs to be the go-to technique because success matters. You just gotta get it done on the, the first attempt. Kids don't tolerate multiple failed attempts very well. Um, obvious downside is that you create a second puncture wound, but in practice, that puncture is usually controlled and much less traumatic than repeated unsuccessful pulling. Depending on where the skin's at, you may actually need to put a little bit of tension or pressure against the skin to get that hook to poke through. Ultimately, this advance and cut method is the one that you should spend the most time learning and teaching to your trainees. The string yank technique is the one that often is seen at summer camps and on YouTube videos. You loop string or heavy suture or even fishing line around the bend of the hook, apply downward pressure to the shank to disengage the barb, and then pull quickly in line with the shaft of the hook. When it works, it yanks it out almost instantly. That's why the YouTube videos are popular. One second there's a fishhook in the finger, and the next there isn't. The advantage is that this can sometimes just be performed without anesthesia and can even be done at home. The disadvantage is obvious if you work with children. This requires cooperation. Younger kids, anxious kids, a treble hook, something that's deeply embedded, like this isn't gonna work all that well, and it's, again, less reliable with bigger and deeply embedded hooks. The last technique is needle cover. This one gets less attention. It seems elegant, but in practice it's actually pretty hard to do, especially in smaller kid parts. You insert an 18-gauge needle alongside the entry tract until the bevel of that needle covers the barb, and then pull both out together The advantage is that you avoid creating a second puncture wound, and you can minimize tissue trauma. The disadvantage is it's really complex technically. Maintaining alignment of both the hook and needle can be tricky because they sort of like roll and move around. And if you want to do this one, it's probably easier for smaller and medium-sized hook rather than larger embedded or treble hooks. And as you might imagine in the literature, there's not really any randomized trials comparing these techniques. Most of what we know comes from prospective observational studies, case series, procedural experience, and expert review. Advance and cut seems to have the broadest success across scenarios. String yank does earn some points for field use and avoiding local numbing. Needle cover is hard to do, but if the parent is absolutely adamant that you don't create a second hole, then that's probably your best option. And as with any procedure, you should probably be facile in multiple techniques in case the first one doesn't work. You don't just want to stand there and flounder. Anyway, most fishhook removals in children can be done with local anesthesia alone. One percent Lido with or without epi is usually enough. Depending on the location, you may need to do a digital block or a field block instead of just injecting directly around the hook because local infiltration itself can distort the anatomy and actually make removal harder. So that's why I like blocking the digit or doing a little bit of a field block around it. If you have time, a topical anesthetic before local infiltration can be a nice gesture. LMX or EMLA can be really helpful, especially for really anxious kids or kids who are escalating before you even start setting up. They take about forty to sixty minutes. About forty-five minutes is probably ideal. So if you can get that put on in triage, that's actually a, a great technique. So if you know you're going to inject to numb to get the fishhook out, and you need a little bit of extra time to get child life or other personnel in the room, by all means, put a topical anesthetic there. It only absorbs into the outer two millimeters, but it'll help with the poke, not necessarily the burning that happens once the lidocaine is in the tissue. And now that we've talked about pain, I think it's also important to talk about anxiolysis. Most kids that have embedded fishhooks don't need full procedural sedation. If it's right next to the eye, like in the eyelid, then that might be beneficial, especially in a preschool-aged kid or younger. Plenty of them do need some anxiolysis. Um, intranasal or oral midazolam is probably, uh, the most popular option. It's got rapid onset in about twenty minutes, no IV, some amnesia. Recent pediatric data suggests that point four or point five milligrams per kilogram may perform better than lower doses, uh, for the intranasal. If you've got nitrous oxide, that's another nice option for cooperative kids. It provides anxiolysis and analgesia with rapid recovery and a very low rate of adverse respiratory events. Fishhook removal is actually one of those procedures where nitrous can feel disproportionately helpful because the procedure itself is often quick, and the hardest part is just reducing the fear and helping the kid hold still for about thirty to sixty seconds. I think ketamine still has a role. I alluded to when I might use that earlier. Occasionally, you walk into the room and then there's a deeply embedded treble hook, a really anxious child, a failed attempt prior to you being there. And ultimately, yes, IV procedural sedation with ketamine should be on the table, and it's as always an excellent option. And never, ever underestimate distraction. Hopefully, you work in a place where there are child life specialists because they are wonderful. They are magic. But you've got videos, you know, music, VR, parents. I mean, sometimes the difference between success and failure is a working iPad. And then finally, the question of antibiotics. So fishhook removal does not automatically equal a course of antibiotics. A prospective series of one hundred fishhook injuries found prophylactic antibiotics were unnecessary for uncomplicated soft tissue injuries that didn't involve the cartilage or tendon. So if you've got a contaminated wound, a delayed presentation, you know, it was already in an established infection, though I've never actually seen someone impale a fishhook into an area of cellulitis. There's tendon involvement, joint involvement, or, you know, gross water exposure. Well, then maybe consider antibiotics. Freshwater injuries do raise concern for organisms like Aeromonas. Saltwater injuries introduce concern for Vibrio species and occasionally Mycobacterium marinum enters the conversation or the tissue. Um, saltwater injuries are often treated with doxycycline plus a third-generation cephalosporin. You recognize the doxy decisions in younger children require some additional consideration. Freshwater injuries could push you towards broader Gram-negative coverage, but, but honestly, for most fishhook injuries, especially in healthy children, you're just dealing with skin flora. So once I get the hook out, I make sure there's no other retained foreign bodies, like little pieces of the hook or little pieces of the barb. I irrigate with saline or tap water, maybe a hundred mLs for a smaller hook, more for bigger hooks or grossly contaminated wounds. Make sure that there's full neurovascular function and normal range of motion. Antibiotic ointment, simple dressing, update their tetanus shot if it's not been within five years, and explain to the family that the good news is that this is really a forgiving injury most of the time. Once the hook is out, these generally heal really well. We don't need to suture them back up. We're not worried about long-term damage. Tell the parents to watch out for increasing redness, worsening pain, pus drainage, fever, or other systemic symptoms, trouble moving the area, especially if it was around a digit, you know, numbness or anything else that makes you concerned that infection has started instead of healing. Families will almost always ask jokingly when they can fish again. Honestly, usually pretty quickly. Just don't put the wound under water until it's healed, and don't stand directly behind whoever is casting. And now for some take-home points. Fishhook removal is a simple and straightforward procedure where technique really matters. You have to know what type of hook is embedded in the skin. Retrograde does work for superficial or barbless hooks, but most fishhooks that I've seen have barbs because they are designed to stay in the fish. Advance and cut is probably the most broadly successful technique. String yank works if you're a YouTuber. Needle cover is really, I think, only for those scenarios where the family does not want a second hole. It's really actually hard to do. Local anesthesia is enough for most kids, so injecting with lidocaine. If you have time, LMX or EMLA helps with the poke a little bit. Routine antibiotics are not usually necessary. And if there's ocular involvement or if it's in a joint, call an ophthalmologist or an orthopedist. Honestly, this is one of those procedures that's really satisfying once you get comfortable with it. I love doing it with our residents and trainees. Families come in expecting something dramatic, and by the time they leave, they're surprised by how straightforward it was. And I guarantee that this is a story that they will tell for years and years. And if you do a good job and make it a good experience and perhaps even a lighthearted one, they are going to remember that. And yeah, you'll be part of somebody's fishing story. So I hope you did enjoy this first episode on minor procedures. I'm gonna do additional ones like these along the way because, you know, I think that they don't get a lot of love when it comes to traditional education. If you've got any ideas for future procedures or topics, please send them my way. As the kids would say, like, rate, and review. If you leave a review on your favorite podcast site, that would really help other people discover the show. I podcast because I think it's a great way to teach, and I've been doing so since 2013. And yes, you can remove a fishhook. Don't let this straightforward procedure become the one that got away. For PEM Currents: The Pediatric Emergency Medicine Podcast, this has been Brad Sobolewski. See you next time.  

Wockhardt's FDA approval of Zaynich marks a historic first, the only drug entirely discovered and developed by an Indian company to clear US-FDA scrutiny. ET’s pharma editor Vikas Dandekar and Rica Bhattacharyya talk to Habil Khorakiwala, Chairperson of Wockhardt who unpacks the 25-year innovation journey behind this milestone. From a deliberate pivot to antibiotics when big pharma was exiting the space, to navigating financial turbulence, asset sales, and regulatory hurdles, Khorakiwala reflects on strategic patience and scientific conviction. He also outlines peak sales projections of $1.5–2 billion, the US commercial roadmap led by daughter Zahabiya, and a robust pipeline of blockbusters ahead.You can follow Vikas Dandekar on his social media: X or Linkedin and Rica Bhattacharyya on her X and Linkedin Check out other interesting episodes like:ET Deep Dive: Swipe Left on Reality,India wants manufacturing at 25% of GDP — will AI in factories help?, Tanay Kothari Wants To Kill The Keyboard, From Doer to Director: The LinkedIn Playbook for the AI Agea, Semaglutide Goes Generic: Big Pharma’s Moat Breaks and much more. Catch the latest episode of ‘The Morning Brief’ on The Economic Times Online, Spotify, Apple Podcasts, JioSaavn, Amazon Music and Youtube.See omnystudio.com/listener for privacy information.

Tick bites and concerns about Lyme disease are increasing, especially during warmer months. In this episode of Health Matters, host Courtney Allison speaks with Dr. Laura Kirkman and Dr. Karen Acker of NewYork-Presbyterian, Weill Cornell Medicine, and NewYork-Presbyterian Komansky Children's Hospital of Children's Hospital of New York about what people should know about ticks and Lyme disease. Dr. Kirkman explains the types of ticks found in the U.S., where they live, and how they attach to the body. She emphasizes that not every tick bite leads to Lyme disease—it depends on the tick species, whether it carries the bacteria, and how long it remains attached. Dr. Acker explains how Lyme disease is transmitted and outlines the stages of infection, including early symptoms such as the characteristic bullseye rash, fever, and fatigue, as well as less common complications involving the nervous system, heart, or joints. The conversation also covers how Lyme disease is diagnosed and treated, including when testing is necessary and when a preventive dose of antibiotics may be recommended after a tick bite. Finally, the doctors share practical strategies to prevent tick bites—from tick checks and proper clothing to repellents and safe tick removal—and discuss emerging concerns like lone star ticks and alpha-gal syndrome. Their key message: with awareness and simple precautions, you can significantly reduce your risk.   Chapters 00:00 – Understanding Ticks and Their Risks Overview of tick species, where they live, and how they interact with humans 04:30 – What Is Lyme Disease? How Lyme disease is transmitted, early symptoms, and stages of infection 08:45 – Diagnosis, Treatment, and Tick Removal When to test for Lyme disease, antibiotic options, and how to safely remove a tick 12:00 – Preventing Tick Bites and Emerging Concerns Prevention strategies, protecting kids and pets, and lone star tick risks   Key Topics Covered Tick species in the U.S. Where ticks live and how they attach Lyme disease transmission Early symptoms of Lyme disease Bullseye rash and warning signs Diagnosis and antibody testing Antibiotic treatment and prevention Proper tick removal techniques Tick bite prevention strategies Lone star tick and alpha-gal syndrome Takeaway Message A tick bite does not automatically mean Lyme disease. By checking for ticks regularly, removing them promptly, and using simple prevention strategies, you can significantly reduce your risk. When caught early, Lyme disease is highly treatable—making awareness and prevention your best tools for staying safe outdoors.   Doctor Bios Dr. Laura Kirkman is a physician-scientist whose research focuses on the molecular pathogenesis of infection with bloodborne parasitic diseases: malaria and babesiosis. Dr. Kirkman received her M.D. from the Albert Einstein College of Medicine with distinction in research where she benefitted from support from a Howard Hughes Medical Student research award. She completed her clinical training in internal medicine at Yale-New Haven Hospital and her infectious disease fellowship at the NewYork-Presbyterian/Weill Cornell Medical Center. She is an associate professor of medicine and microbiology and immunology at Weill Cornell Medicine.   Dr. Karen Acker is a pediatric hospital epidemiologist at NewYork-Presbyterian Komansky Children's Hospital of Children's Hospital of New York, and an assistant professor in clinical pediatrics at Weill Cornell Medicine. She received her medical degree from SUNY Downstate Medical Center followed by a residency in pediatrics at NewYork-Presbyterian/Weill Cornell Medical Center. After completing her fellowship in pediatric infectious diseases at NewYork-Presbyterian/Columbia University Irving Medical Center in 2018, she joined the pediatric infectious disease division at Weill Cornell Medicine, and has served as a hospital epidemiologist since 2019. Her clinical and research interests include the epidemiology of infectious outbreaks and healthcare-associated infections, diagnostic stewardship, Staphylococcus aureus infections, respiratory viral infections in children, and factors influencing vaccine uptake in children. Dr. Acker is board-certified in pediatrics and board-certified for pediatric infectious diseases.

Honey has received a lot of hype over recent years. More than just being tasty on your toast, it may also act as an antibiotic, and even more. So what are the facts?  

Send us Fan MailAntibiotics are life-saving - and - they can also temporarily disrupt your gut microbiome, digestion, energy, and even mood. In this episode, Selin breaks down a simple, food-first approach to restoring gut health after antibiotics without extremes, confusion, or over-supplementing.You'll learn what to focus on in the first few weeks after antibiotics, which foods help rebuild beneficial gut bacteria in a realistic, sustainable way.This is a grounded guide for anyone feeling bloated, off, fatigued, or “not quite themselves” after antibiotic use that wants a clear reset path back.Support the showDive Deeper On Your Journey:☆ Book your complimentary first acupuncture session. ☆ Let's connect on Instagram ☆ Explore The Painless Period Guide ☆ Discover the Goddess Affirmation Colouring Book 

In this episode, Tracey Davidoff, MD, Joe Toscano, MD, and Evan Nelson, MD, discuss the May 2026 Evidence-Based Urgent Care article, Urgent Care Evaluation and Management of Acute Bronchitis.0:08 Introduction1:08 Topic & guest introduction2:14 Differential diagnosis4:03 Respiratory virus testing6:42 Positive viral diagnosis & antibiotic prescribing8:00 Duration of cough & post-infectious cough9:41 Antibiotic stewardship12:07 Cough & cold medicines14:44 Narcotics & corticosteroids16:05 Steroid stewardship17:24 Radiologic stewardship & chest X-rays20:46 Sputum color21:53 Albuterol24:21 Special populations25:37 Take-home points & patient education27:08 Wrap-up and outroSubscribes, take the CME test here!Not a subscriber? Join here!

Helen Brough joins the Saranya to reflect on her work in paediatric food allergy, from personal experiences that shaped her career to landmark studies like LEAP, EAT, and ProNuts that transformed prevention and management. This episode explores early allergen introduction, evolving approaches to treatment, and what's driving the rise in food allergies in children.  Timestamps:   00:53 –  Raising children with atopy  02:18 – Antibiotic exposure at birth  03:08 – Prevention of peanut allergies   05:22 – Introducing other allergens 08:09 – Multi-nut/sesame allergy  10:41 – Immunotherapy for severe allergies  13:36 – Prevalence of food allergies 

A mom's teenage son has refused to shower, and the stench is tough to be around. What is a tell-tale sign a marriage isn't going to make it, and have you ever heard of a cosmetic cauliflower ear? Guys are getting surgery to have that look. A man faked being blind for years and received VA benefits; guess where he is. Plus power walking washes your brain. Is Chipotle skimping on your order, plus a McDonalds employee was caught putting fries in her mouth, then putting them back in the serving box; and surprisingly, she no longer works there. Welcome in!

The ESCMID Global Late Breakers series returns to Communicable! Five CMI Communications editors – Marc Bonten, Josh Davis, Angela Huttner, Anne-Grete Märtson, and Erin McCreary – handpicked five late-breaking trials presented at ESCMID Global 2026 to summarise their  findings and discuss whether the results will change their practice. This is part one of the two-part series. Trials presented are listed below and links to their respective sessions can be watched and rewatched on the ESCMID Global Virtual Platform. Links to corresponding publications, if available, and mentioned related articles are provided as well. The FAST trial (Late-breaking research from JAMA)Banerjee R, et al. Fast Antimicrobial Susceptibility Testing for Gram-Negative Bacteremia. The FAST Randomized Clinical Trial, doi: 10.1001/jama.2026.5487 Srinivasan A. A Multinational Trial of Rapid Antimicrobial Susceptibility Testing. Is FASTer Better?, doi: 10.1001/jama.2026.5504The CEFMEC trial (Poster session)Hayakawa K, et al. Effectiveness of cefmetazole versus meropenem for invasive urinary tract infections caused by extended-spectrum β-lactamase-producing Escherichia coli, Antimicrob Agents Chemother 2023, doi: 10.1128/aac.00510-23The COBRA trial (Late-breaking trials in surgical infection prevention)Overdevest AG, et al. Antibiotic treatment for 1 day versus 4-7 days in patients with acute cholangitis after adequate endoscopic biliary drainage (COBRA): study protocol for a randomized controlled trial. Trials, doi: 10.1186/s13063-026-09524-7The DOTS trial, a secondary analysis (Late-breaking research from JAMA)Lodise, TP, et al. Pharmacokinetics of Dalbavancin in Complicated Staphylococcus aureus Bacteremia: A Secondary Analysis of the DOTS Randomized Clinical Trial, JAMA 2026, doi: 10.1001/jamanetworkopen.2026.11652 Walls G, et al. Patient-reported Perceptions, Experiences, and Preferences Around Intravenous and Oral Antibiotics for the Treatment of Staphylococcus aureus Bacteremia: A Descriptive Qualitative Study, Clin Infect Dis 2026, doi: 10.1093/cid/ciaf522Turner  NA , et al.  Dalbavancin for treatment of Staphylococcus aureus bacteremia: the DOTS randomized clinical trial. JAMA 2025, doi: 10.1001/jama.2025.12543 Maribavir for clinically significant cytomegalovirus infection in hematopoietic cell transplantation: a real-world retrospective international study of the Infectious Disease Working Party of EBMT (Late-breaking research from The Lancet)Paviglianiti A, et al. Maribavir for clinically significant cytomegalovirus infection in haematopoietic cell transplant recipients in Europe: a real-world multicentre retrospective registry study. Lancet 2026. doi: 10.1016/S1473-3099(26)00144-1

This episode considers how antibiotic use can be safely reduced in children in high-risk scenarios or with severe infections. To discuss this we are joined by Dr Nadja Vissing and Dr Ulrikka Nygaard, paediatric infectious disease specialists from Copenhagen University Hospital, who led a randomized controlled trial in Denmark evaluating the early discontinuation of empirical antibiotics versus extended treatment in children with cancer and high-risk febrile neutropenia. We hear about the importance of this trial for children with cancer and their families as well as for broader antimicrobial stewardship. We discuss other recent RCTs that are informing safely reducing antibiotic exposure in children with urinary tract infections, uncomplicated bone and joint infections and probable early onset neonatal sepsis. Nadja and Ulrikka share with listeners their take home messages related to antibiotic decision-making from these trials along with words of wisdom and motivation for other paediatric clinical trialists. Click here to read the full article: https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(26)00039-8/fulltext

Arreaza: Welcome back tothe Rio Bravo qWeek Podcast! My name is Dr. Hector Arreaza, I am a family physician and faculty member in the Rio Bravo Family Medicine Residency Program. Today I am joined by two excellent medical students who will introduce themselves now, welcome, guys! Mehr: Thank you for the introduction! My name is Mehr Boparai, third year medical student at WesternU COMP-NW. Jeremy: And my name is Jeremy Pan, also a third-year medical student at WesternU COMP Pomona and we will be discussing a very prevalent topic today in the clinical world that is arguably becoming one of the biggest threats to modern medicine: antibiotic resistance. Mehr: That's right! Imagine this scenario: a routine infection, something we've treated easily for decades, suddenly becomes life-threatening because the drugs we always thought we could rely on just don't work anymore. You likely ran into this problem just last week with one of your patients! That's not science fiction. That's happening every day in hospitals across the world. Dr. Arreaza: I agree, antibiotic resistance must be taken seriously. I increased my awareness in 2023, when I attended a medical research conference in Carmel(which is a popular conference that takes place in that beautiful town). I heard Dr. David Gilbert, a famous and accomplished ID doctor who helped develop the Sanford Guide to Antimicrobial Therapy, he warned everyone about antibiotic resistance as one of the biggest threats for humanity, the other two were a nuclear bomb and an epidemic. Jeremy: Woah, comparing antibiotic resistance to a nuclear bomb is absolutely crazy, but likely very real!! Well today, we're going to be focusing on five of the most common infections or “bugs” you'll see in a hospital setting. We'll talk about what typically causes them, what antibiotics we used to rely on, and what happens when resistance decides to enter the picture. Mehr: If you are a medical student (or resident), you understand that dreaded feeling when an attending asks “what antibiotics should we start?” But don't worry, in this episode, we hope to address the decision-making process in a simple framework. What is Antibiotic Resistance? Dr. Arreaza:  Before we jump into specific common infections and pathogens, let's cover our basics. Antibiotic resistance occurs when bacteria evolve to survive drugs designed to kill them. This can happen through genetic mutations or by getting resistance genes from other bacteria. Why does this matter? Jeremy: It matters because antibiotics play a huge role in modern medicine. Without them, surgeries, chemotherapy, organ transplants—even childbirth—become significantly more dangerous. Mehr: According to the CDC, in the U.S. alone, antibiotic-resistant infections affect over 2.8 million people each year and cause more than 35,000 deaths! So, when we talk about resistance, we're not just talking about inconvenience for treatments. We're talking about a fundamental threat to healthcare. Staph aureus Dr. Arreaza: So, if you have a patient who comes in with a skin infection or is maybe showing signs of pneumonia or bacteremia, what is one of the most common bugs that you should think about? Jeremy: Staph aureus! Typically to treat methicillin-sensitive strains (MSSA), we would utilize antibiotics like nafcillin, oxacillin, or cefazolin. But there is one strain in particular that is worrisome, Mehr? Mehr: yeap, that would have to be MRSA, one of the most well-known resistant organisms. MRSA is resistant to all beta-lactam antibiotics, which means we can say goodbye to all penicillin and most cephalosporins. Dr. Arreaza: And what is the first antibiotic that comes to mind if we see MRSA on a culture in the hospital? Mehr: Vancomycin! Alternative treatments include linezolid and daptomycin depending on the type of infection. But what is the problem that we are starting to see? Jeremy: You guessed it, cases of resistance to vancomycin are starting to appear—VRSA. These cases are still uncommon today, but these findings show a worrying trend, that we will eventually start running out of reliable options. Dr. Arreaza: Fortunately, VRSA infections are extremely rare, with only 14-16 documented cases in the United States. As of 2019, 52 VRSA strains have been identified in the United States, India, Iran, Pakistan, Brazil, and Portugal. Let's keep an eye on VRSA in the future.  E. coli Dr. Arreaza: Alright, so let's say you have a patient with dysuria, urinary frequency, maybe even a catheter in place. What's the most common bug you're thinking of? Mehr: That one's a classic, we are thinking E. coli. Jeremy: Exactly. E. coli is the leading cause of urinary tract infections, especially in both community and hospital settings. Dr. Arreaza: So Jeremy, what are we using for uncomplicated UTIs? Jeremy: We usually think of trimethoprim-sulfamethoxazole, nitrofurantoin, or sometimes fosfomycin. And in more complicated cases, we might consider fluoroquinolones like ciprofloxacin. Mehr: But here's where things get tricky. Resistance to TMP-SMX and fluoroquinolones has been increasing significantly. In some areas, resistance rates are over 20–30%, which really changes your empiric choices. Conclusion: Dr. Arreaza: So we've talked about five major organisms today: Staph aureus, E. coli, Klebsiella, Pseudomonas, and C. diff. What's the overarching takeaway of the discussion? Jeremy: The main takeway is that antibiotic resistance is already here, and it's affecting some of the most common infections we see in clinical practice on a day-to-day basis. Mehr: And as students and future physicians, it's important to not just memorize antibiotics, but understand why we're choosing them. Dr. Arreaza: Exactly. Always think: What organism am I targeting? What are the local resistance patterns? And can I narrow therapy once I have cultures? Jeremy: And maybe most importantly—don't overuse antibiotics, especially in cases when they're not needed. Mehr: Because the more we use them, the faster we lose them. Dr. Arreaza: I'd like to share the story I listed to in a RadioLab episode about Dr Steffanie A. Strathdee, one of the most influential ID doctors in the world and Co-Director at the Center for Innovative Phage Applications and Therapeutics (IPATH). She shared that her husband got infected by Acinetobacter baumannii, an opportunistic infection that can cause severe infection. After trying many antibiotics, he was treated with “phages”, “bacteriophages”. So, that's part of “thinking out of the box”. Jeremy: Thank you all for tuning in to the Rio Bravo qWeek podcast series and thank you Dr. Arreaza for having Mehr and me on the podcast today! Stay informed, stay curious—and we'll see you next time Mehr: Guys! I had so much fun! We hope this episode helped simplify antibiotic selection for the most common infections and bugs seen in a hospital setting and gave you a framework you can for initial treatments and cases of antibiotic resistance. Thanks for hanging out with us!  Dr. Arreaza: And remember, antibiotics are one of the most powerful tools we have in medicine. Let's use them wisely. This is Dr. Arreaza, signing off.  _____________________ References: Radiolab. (2026, March 27). Antibiotic apocalypse. WNYC Studios. https://radiolab.org/podcast/antibiotic-apocalypse Metlay, J. P., Waterer, G. W., Long, A. C., et al. (2019). Diagnosis and treatment of adults with community-acquired pneumonia: An official clinical practice guideline of the American Thoracic Society and Infectious Diseases Society of America. American Journal of Respiratory and Critical Care Medicine, 200(7), e45–e67. https://www.idsociety.org/practice-guideline/community-acquired-pneumonia-cap-in-adults/ Gilbert, D. N., Chambers, H. F., Saag, M. S., et al. (2026). The Sanford Guide to Antimicrobial Therapy (56th ed.). Antimicrobial Therapy, Inc. Centers for Disease Control and Prevention. (2025, September 17). Antibiotic stewardship resource bundles. https://www.cdc.gov/antibiotic-use/hcp/educational-resources/stewardship/index.html Theme song, Works All The Time by Dominik Schwarzer, YouTube ID: CUBDNERZU8HXUHBS, purchased from https://www.premiumbeat.com/.   Even without trying, every night you go to bed a little wiser. Thanks for listening to Rio Bravo qWeek Podcast. We want to hear from you, send us an email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week!

Send us Fan MailDr. Gesca Borchardt, third-year neonatology fellow at Winnie Palmer Hospital, presents findings from a retrospective study of 296 infants born under 25 weeks examining whether extending empiric antibiotic use beyond 72 hours reduces mortality in this vulnerable population. She shares why her unit moved to a seven-day antibiotic course for babies with placental pathology positive for chorioamnionitis — and what they found when they looked at the data. At 22 and 23 weeks, longer antibiotic courses were associated with a statistically significant decrease in mortality. At 24 weeks, no difference was seen. One puzzling finding clouds the picture however: an increased incidence of spontaneous intestinal perforation in the prolonged antibiotic group — a signal the team is still trying to understand and that the wider community will want to watch closely.Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!

Dietitian Nutritionist Leyla Muedin discusses a Stanford-led randomized controlled trial published in Nature Medicine in which a five-day, calorie-restricted fasting-mimicking diet improved symptoms and inflammatory markers in people with mild to moderate Crohn's disease. In the three-month study of 97 patients, 65 followed monthly five-day cycles of 700–1100 calories/day with plant-based meals, while 32 continued usual diets; about two-thirds of the fasting-mimicking group reported symptom improvement, with fatigue and headaches but no serious side effects, and fecal calprotectin and other inflammatory molecules decreased. She notes bowel rest and the specific carbohydrate diet as additional approaches. The episode also explains how antibiotics can cause diarrhea by disrupting gut bacteria, lists higher-risk antibiotics, offers supportive steps (hydration, BRAT foods, avoiding irritants), recommends Saccharomyces boulardii taken away from antibiotics, and outlines warning signs requiring medical care, including possible C. difficile.

Part one of this quarter's edition of Unearthed! includes animals, artwork, edibles and potables, shipwrecks, potpourri. Research: Abdallah, Hannah. “Analysis of charred food in pot reveals that prehistoric Europeans had surprisingly complex cuisines.” EurekAlert. 3/4/2025. https://www.eurekalert.org/news-releases/1117763 Almeroth-Williams, Thomas. “British redcoat’s lost memoir reveals harsh realities of life as a disabled veteran.” EurekAlert. 1/14/2026. https://www.eurekalert.org/news-releases/1111595 Anderson, Sonja. “Does This Skeleton Found Beneath a Dutch Church Belong to D’Artagnan, the Man Who Inspired ‘The Three Musketeers’?” Smithsonian. 3/27/2026. https://www.smithsonianmag.com/smart-news/this-skeleton-found-beneath-the-floor-of-a-dutch-church-may-belong-to-dartagnan-the-fourth-musketeer-180988448/ Anderson, Sonja. “Historians Thought This Rare Renaissance Portrait by One of the First Famous Female Artists Was Lost to History—Until It Surfaced in North Carolina.” 2/3/2026. https://www.smithsonianmag.com/smart-news/historians-thought-this-rare-renaissance-portrait-by-one-of-the-first-famous-female-artists-was-lost-to-history-until-it-surfaced-in-north-carolina-180988120/ Anderson, Sonja. “Hundreds of Ancient Roman Blade Sharpeners Emerge From a Riverbank in England, Revealing the Ruins of a 2,000-Year-Old Whetstone Factory.” Smithsonian. 1/20/2026. https://www.smithsonianmag.com/smart-news/hundreds-of-ancient-roman-blade-sharpeners-emerge-from-a-riverbank-in-england-revealing-the-ruins-of-a-2000-year-old-whetstone-factory-180988016/ Anderson, Sonja. “The Italian Government Just Paid Nearly $35 Million for a Rare Caravaggio Portrait—One of the Most Expensive Artworks It’s Ever Acquired.” Smithsonian. 3/16/2026. https://www.smithsonianmag.com/smart-news/the-italian-government-just-paid-nearly-35-million-for-a-rare-Caravaggio-portrait-one-of-the-most-expensive-artworks-its-ever-acquired-180988344/ Arnold, Paul. “Poop as medicine? A Roman vial's chemistry backs up ancient medical texts.” Phys.org. 2/4/2026. https://phys.org/news/2026-02-poop-medicine-roman-vial-chemistry.html Arnold, Paul. “Scents of the afterlife: Identifying embalming recipes by 'sniffing' the air around Egyptian mummies.” Phys.org. 2/5/2026. https://phys.org/news/2026-02-scents-afterlife-embalming-recipes-sniffing.html#google_vignette Bacon, Jordan. “English history’s biggest march is a myth – King Harold sailed to the Battle of Hastings.” EurekAlert. 3/20/2026. https://www.eurekalert.org/news-releases/1120082 Bastola, Kunjal. “A Groundskeeper Noticed a Sinkhole on a Golf Course. It Turned Out to Be a Wine Cellar Full of Empty Bottles, Untouched for More Than 100 Years.” Smithsonian. 3/19/2026. https://www.smithsonianmag.com/smart-news/a-groundskeeper-noticed-a-sinkhole-on-a-golf-course-it-turned-out-to-be-a-wine-cellar-full-of-empty-bottles-untouched-for-more-than-100-years-180988379/ Bastola, Kunjal. “A Little Boy’s Library Book Was Due in 1989. Thirty-Six Years Later, He Realized His Parents Had Never Returned It.” Smithsonian. 1/26/2026. https://www.smithsonianmag.com/smart-news/a-little-boys-library-book-was-due-in-1989-thirty-six-years-later-he-realized-his-parents-had-never-returned-it-180988046/ Baum, Stephanie. “Ancient parrot DNA reveals sophisticated, long-distance animal trade network pre-dating the Inca Empire.” 3/10/2026. https://phys.org/news/2026-03-ancient-parrot-dna-reveals-sophisticated.html Baum, Stephanie. “From the Late Bronze Age to today, the Old Irish Goat carries 3,000 years of Irish history.” 2/26/2026. https://phys.org/news/2026-02-late-bronze-age-today-irish.html Benzine, Vittoria. “What Did Pompeii Smell Like? A New Study Analyzes Its Ancient Incense.” Artnet. 3/31/2026. https://news.artnet.com/art-world/pompeii-ritual-incense-study-2760240 Brooks, James. “Danish warship sunk by Nelson’s British fleet discovered after 225 years.” Associated Press. 4/2/2026. https://apnews.com/article/denmark-archaeologists-warship-nelson-copenhagen-dannebroge-lynetteholm-4519533d9e774a490f6020e893634e09 Carvajal, Guillermo. “Archaeologists achieve a historic milestone by dating French cave paintings with carbon-14 for the first time.” 3/10/2025. https://www.labrujulaverde.com/en/2026/03/archaeologists-achieve-a-historic-milestone-by-dating-french-cave-paintings-with-carbon-14-for-the-first-time/ Clayworth, Liv. “Bird poop powered the rise of the Chincha Kingdom, archaeologists find.” EurekAlert. 2/11/2026. https://www.eurekalert.org/news-releases/1115214 “Lost page of the Archimedes Palimpsest identified in Blois, central France.” Phys.org. 3/9/2026. https://phys.org/news/2026-03-lost-page-archimedes-palimpsest-blois.html Ehrlich, Claudia. “Signs on Stone Age objects: Precursor to written language dates back 40,000 years.” EurekAlert. 2/23/2026. https://www.eurekalert.org/news-releases/1117179 Ferrer, Isabel. “Is d’Artagnan lying beneath a church in Maastricht? DNA will determine if remains found are those of the famous musketeer.” El Pais. 3/25/2025. https://english.elpais.com/international/2026-03-25/is-dartagnan-lying-beneath-a-church-in-maastricht-dna-will-determine-if-remains-found-are-that-of-the-famous-musketeer.html?outputType=amp Gebauer, Kathryn. “Groundbreaking discovery reveals Africa’s oldest cremation pyre and complex ritual practices.” EurekAlert. 1/1/2016. https://www.eurekalert.org/news-releases/1111191 Harley, Sadie. “Iron Age dental plaque reveals Scythians consumed milk from horses and ruminants.” Phys.org. 1/21/2026. https://phys.org/news/2026-01-iron-age-dental-plaque-reveals.html He, Ye. “Singapore’s first ancient shipwreck reveals record cargo of Yuan dynasty blue-and-white porcelain.” EurekAlert. 2/12/2026. https://www.eurekalert.org/news-releases/1116512 Johansen, Rikke Tørnsø. “Archaeologists reveal a medieval super ship: "It's the World’s largest cog".” Vikingeskibs Museet. 12/22/2025. https://www.vikingeskibsmuseet.dk/en/news/archaeologists-reveal-a-medieval-super-ship-its-the-worlds-largest-cog Kasal, Krystal. “Hannibal's famous war elephants: Single bone in Spain offers first direct evidence.” Phys.org. 2/5/2026. https://phys.org/news/2026-02-hannibal-famous-war-elephants-bone.html Kasal, Krystal. “Oldest known sewn hide and other artifacts from Oregon caves shed light on early clothing in harsh climates.” Phys.org. 2/10/2026. https://phys.org/news/2026-02-oldest-sewn-artifacts-oregon-caves.html Killgrove, Kristina. “Romans used human feces as medicine 1,900 years ago — and used thyme to mask the smell.” 1/29/2026. https://www.livescience.com/archaeology/romans/romans-used-human-feces-as-medicine-1-900-years-ago-and-used-thyme-to-mask-the-smell Killgrove, Kristina. “Stone Age woman was buried like a man, revealing flexible gender roles 7,000 years ago in Hungary.” LiveScience. 3/3/2026. https://www.livescience.com/archaeology/stone-age-woman-was-buried-like-a-man-revealing-flexible-gender-roles-7-000-years-ago-in-hungary Koc University. “Earliest evidence of indigo-dyed textiles and single-needle knitting discovered in Bronze Age Anatolia.” Phys.org. 2/21/2026. https://phys.org/news/2026-02-earliest-evidence-indigo-dyed-textiles.html Kuta, Sarah. “Did Neanderthals Use Birch Bark Tar as an Antibiotic to Treat Wounds and Infections?” Smithsonian. 3/30/2026. https://www.smithsonianmag.com/smart-news/did-neanderthals-use-birch-bark-tar-as-an-antibiotic-to-treat-wounds-and-infections-180988393/ Kuta, Sarah. “Ostrich Eggshells Suggest Our Ancestors May Have Understood Basic Geometry 60,000 Years Ago.” Smithsonian. 3/9/2026. https://www.smithsonianmag.com/smart-news/these-intricately-decorated-ostrich-eggshells-suggest-our-ancestors-may-have-understood-basic-geometry-60000-years-ago-180988315/ Kuta, Sarah. “Ötzi the Iceman May Have Carried a Cancer-Causing Strain of HPV, a Common Virus Still Plaguing Humans Today.” Smithsonian. 1/20/2026. https://www.smithsonianmag.com/smart-news/otzi-the-iceman-may-have-carried-a-cancer-causing-strain-of-hpv-a-common-virus-still-plaguing-humans-today-180988024/ Kuta, Sarah. “Shipwreck Timbers Appeared on a Beach After a Storm. They Had Been Buried Beneath the Sand Since the 17th Century.” Smithsonian. 3/2/2026. https://www.smithsonianmag.com/smart-news/shipwreck-timbers-appeared-on-a-beach-after-a-storm-they-had-been-buried-beneath-the-sand-since-the-17th-century-180988260/ Lawson-Tancred, Jo. “Salvador Dalí’s Largest Work Snapped Up by Florida Museum.” Artnet. 3/27/2026. https://news.artnet.com/market/salvador-dali-largest-work-bonhams-sale-2749246 Lock, Lisa. “Ancient DNA finds 15,800-year-old dogs in Anatolia, buried like humans.” Phys.org. 3/28/2026. https://phys.org/news/2026-03-ancient-dna-year-dogs-anatolia.html Lock, Lisa. “Are one in 200 men really related to Genghis Khan? Maybe not, according to a new study.” Phys.org. 2/21/2026. https://phys.org/news/2026-02-men-genghis-khan.html Lucibella, Michael. “Prehistoric tool made from elephant bone is the oldest discovered in Europe.” EurekAlert. 1/26/2026. https://www.eurekalert.org/news-releases/1113140 Luscombe, Richard. “Mass grave in Jordan sheds new light on world’s earliest recorded pandemic.” The Guardian. 1/31/2026. https://www.theguardian.com/science/2026/jan/31/plague-of-justinian-pandemic net. “Did King Harold Sail to Hastings? New Study Sparks Debate Among Historians.” 3/2026. https://www.medievalists.net/2026/03/did-king-harold-sail-to-hastings-new-study-sparks-debate-among-historians/ net. “Viking-Age Woman Buried with Her Dog in Norway.” 3/2026. https://www.medievalists.net/2026/03/viking-age-woman-buried-with-her-dog-in-norway/ Newcastle University Press Office. “5,300-year-old ‘bow drill’ rewrites story of ancient Egyptian tools.” 2/9/2026. https://www.ncl.ac.uk/press/articles/latest/2026/02/ancientegyptiandrillbit/ Noraz, R., Chauvey, L., Wagner, S. et al. Ancient DNA reveals 4000 years of grapevine diversity, viticulture and clonal propagation in France. Nat Commun 17, 2494 (2026). https://doi.org/10.1038/s41467-026-70166-z Nordin, Gunilla. “World’s oldest arrow poison – 60,000-year-old traces reveal early advanced hunting techniques.” 1/7/2026. https://www.eurekalert.org/news-releases/1111624 Parco Archaeologico de Ercolano. “Archaeology: New precious decorations discovered at Villa Sora in the Herculaneum Park.” 2/5/2026. https://ercolano.cultura.gov.it/archaeology-new-precious-decorations-discovered-at-villa-sora-in-the-herculaneum-park/?lang=en Paul, Andrew. “Hiker finds 3,000-year-old bull sculpture in Spain.” Popular Science. 3/17/2026. https://www.popsci.com/science/hiker-finds-bronze-age-bull-spain/ Potter, Lisa. “A wild potato that changed the story of agriculture in the American Southwest.” EurekAlert. 1/21/2026. https://www.eurekalert.org/news-releases/1113056 “Digital scans unveil new love notes and sketches on ancient Pompeii wall.” 1/19/2026. https://www.reuters.com/science/digital-scans-unveil-new-love-notes-sketches-ancient-pompeii-wall-2026-01-19/ Richard L. Rosencrance et al. ,Complex perishable technologies from the North American Great Basin reveal specialized Late Pleistocene adaptations. Sci. Adv. 12, eaec2916(2026).DOI:10.1126/sciadv.aec2916 Ruse, Amy. “Tasmanian tiger lives on in Arnhem Land rock art.” EurekAlert. 3/30/2026. https://www.eurekalert.org/news-releases/1121955 Ruse, Amy. “World’s oldest rock art holds clues to early human migration to Australia.” EurekAlert. 1/21/2026. https://www.eurekalert.org/news-releases/1112900 Siehoff, Jonas. “Hygienic conditions in Pompeii's early baths were poor.” 1/12/2026. https://www.eurekalert.org/news-releases/1112403 Taçon, P. S. C., A.Jalandoni, S. K.May, J.Nganjmirra, and C.Mungulda. 2026. “The Devil Is in the Detail: Tasmanian Devil and Tasmanian Tiger Paintings From Awunbarna and Injalak Hill, Northern Territory, Australia.” Archaeology in Oceania. https://doi.org/10.1002/arco.70024 The History Blog. “$40 estate sale find by early African-American silversmith sells for $24,000.” 2/4/2026. https://www.thehistoryblog.com/archives/75294 The History Blog. “43,000 ostraca found at one site shed light on social history of Egypt.” 5/15/2026. https://www.thehistoryblog.com/archives/75609 The History Blog. “British Museum acquires Tudor Heart.” 2/10/2026. https://www.thehistoryblog.com/archives/75343 The History Blog. “Exceptional Roman cargo shipwreck found in Lake Neuchâtel.” 3/29/2026. https://www.thehistoryblog.com/archives/75705 The History Blog. “Extraordinary find: 10th c. bronze wheel cross matches mold found 43 years ago.” 1/24/2026. https://www.thehistoryblog.com/archives/75220 The History Blog. “Previously unknown Hans Baldung Grien portrait emerges after 500 years in the sitter’s family.” 1/17/2026. https://www.thehistoryblog.com/archives/75161 The History Blog. “Roman wooden writing tablets from Belgium deciphered.” 1/22/2206. https://www.thehistoryblog.com/archives/75207 Thomas, Laura. “A century-old Stonehenge mystery may finally be solved.” Science Daily. 1/27/2026. https://www.sciencedaily.com/releases/2026/01/260127010208.htm Thorsberg, Christian. “The National Gallery of Art Acquires 17th-Century Masterpiece by Baroque Painter Artemisia Gentileschi.” Smithsonian. 2/7/2026. https://www.smithsonianmag.com/smart-news/the-national-gallery-of-art-acquired-17th-century-masterpiece-by-baroque-painter-artemisia-gentileschi-180988147/ Thorsberg, Christian. “This Luxury Steamer Disappeared on a Stormy Night in 1872. Nearly 150 Years Later to the Day, It Was Found at the Bottom of Lake Michigan.” Smithsonian. 2/18/2026. https://www.smithsonianmag.com/smart-news/this-luxury-steamer-disappeared-on-a-stormy-night-in-1872-nearly-150-years-to-the-day-it-was-found-in-the-bottom-of-lake-michigan-180988204/ Unibo Magazine. “Humanity’s oldest geometries, engraved on ostrich eggs.” https://magazine.unibo.it/en/articles/humanitys-oldest-geometries-engraved-on-ostrich-eggs University of Tübingen. “Earliest hand-held wooden tools found in Greece date back 430,000 years.” Phys.org. 1/1/2026. https://phys.org/news/2026-01-earliest-held-wooden-tools-greece.html Villotte, S., T.Szeniczey, S.Kacki, and A.Anders. 2026. “Fixed and Fluid: The Two Faces of Gender Roles—A Combined Study of Activity Patterns and Burial Practices in the European Neolithic.” American Journal of Biological Anthropology189, no. 2: e70217. https://doi.org/10.1002/ajpa.70217. Whiddington, Richard. “3,300-Year-Old Papyrus Reveals How Ancient Egyptians Fixed Drawing Mistakes.” ArtNet. 3/9/2026. https://news.artnet.com/art-world/ancient-egyptian-papyrus-white-out-fluid-2752125 Whiddington, Richard. “Long-Lost Archimedes Text Resurfaces in French Museum.” Artnet. 3/11/2026. https://news.artnet.com/art-world/lost-page-of-archimedes-palimpsest-found-2753005 Whiddington, Richard. “Lost Parthenon Piece Unearthed From Lord Elgin’s Shipwreck.” ArtNet. 3/19/2026. https://news.artnet.com/art-world/parthenon-fragment-lord-elgin-shipwreck-2755894 Zeilsgtra, Andrew. “Breathing in the past: How museums can use biomolecular archaeology to bring ancient scents to life.” EurekAlert. 2/5/2026. https://www.eurekalert.org/news-releases/1114918 Zinin, Andrew. “600-year-old pinot noir grape found in medieval French toilet.” Phys.org. 3/24/2026. https://phys.org/news/2026-03-year-pinot-noir-grape-medieval.html#google_vignette See omnystudio.com/listener for privacy information.

Mike, Cam, and producer Ellen return for a spring update featuring Jim's recovery saga and his surprising search for a gluten-free Z-Pak. The guys explore new research linking antibiotic-disrupted microbiomes to non-celiac gluten sensitivity and share a UK listener's story on international diagnosis hurdles. They also celebrate a long-time listener  who was inspired by the podcast to launch her own gluten-free business to help others. Mike and cam wrap up the episode with a look at the "human factor" in restaurant safety, and sobering global data on celiac diet adherence.

Part one of this quarter's edition of Unearthed! features updates, medical things, books and letters, oldest known things, and smells. Research: Abdallah, Hannah. “Analysis of charred food in pot reveals that prehistoric Europeans had surprisingly complex cuisines.” EurekAlert. 3/4/2025. https://www.eurekalert.org/news-releases/1117763 Almeroth-Williams, Thomas. “British redcoat’s lost memoir reveals harsh realities of life as a disabled veteran.” EurekAlert. 1/14/2026. https://www.eurekalert.org/news-releases/1111595 Anderson, Sonja. “Does This Skeleton Found Beneath a Dutch Church Belong to D’Artagnan, the Man Who Inspired ‘The Three Musketeers’?” Smithsonian. 3/27/2026. https://www.smithsonianmag.com/smart-news/this-skeleton-found-beneath-the-floor-of-a-dutch-church-may-belong-to-dartagnan-the-fourth-musketeer-180988448/ Anderson, Sonja. “Historians Thought This Rare Renaissance Portrait by One of the First Famous Female Artists Was Lost to History—Until It Surfaced in North Carolina.” 2/3/2026. https://www.smithsonianmag.com/smart-news/historians-thought-this-rare-renaissance-portrait-by-one-of-the-first-famous-female-artists-was-lost-to-history-until-it-surfaced-in-north-carolina-180988120/ Anderson, Sonja. “Hundreds of Ancient Roman Blade Sharpeners Emerge From a Riverbank in England, Revealing the Ruins of a 2,000-Year-Old Whetstone Factory.” Smithsonian. 1/20/2026. https://www.smithsonianmag.com/smart-news/hundreds-of-ancient-roman-blade-sharpeners-emerge-from-a-riverbank-in-england-revealing-the-ruins-of-a-2000-year-old-whetstone-factory-180988016/ Anderson, Sonja. “The Italian Government Just Paid Nearly $35 Million for a Rare Caravaggio Portrait—One of the Most Expensive Artworks It’s Ever Acquired.” Smithsonian. 3/16/2026. https://www.smithsonianmag.com/smart-news/the-italian-government-just-paid-nearly-35-million-for-a-rare-Caravaggio-portrait-one-of-the-most-expensive-artworks-its-ever-acquired-180988344/ Arnold, Paul. “Poop as medicine? A Roman vial's chemistry backs up ancient medical texts.” Phys.org. 2/4/2026. https://phys.org/news/2026-02-poop-medicine-roman-vial-chemistry.html Arnold, Paul. “Scents of the afterlife: Identifying embalming recipes by 'sniffing' the air around Egyptian mummies.” Phys.org. 2/5/2026. https://phys.org/news/2026-02-scents-afterlife-embalming-recipes-sniffing.html#google_vignette Bacon, Jordan. “English history’s biggest march is a myth – King Harold sailed to the Battle of Hastings.” EurekAlert. 3/20/2026. https://www.eurekalert.org/news-releases/1120082 Bastola, Kunjal. “A Groundskeeper Noticed a Sinkhole on a Golf Course. It Turned Out to Be a Wine Cellar Full of Empty Bottles, Untouched for More Than 100 Years.” Smithsonian. 3/19/2026. https://www.smithsonianmag.com/smart-news/a-groundskeeper-noticed-a-sinkhole-on-a-golf-course-it-turned-out-to-be-a-wine-cellar-full-of-empty-bottles-untouched-for-more-than-100-years-180988379/ Bastola, Kunjal. “A Little Boy’s Library Book Was Due in 1989. Thirty-Six Years Later, He Realized His Parents Had Never Returned It.” Smithsonian. 1/26/2026. https://www.smithsonianmag.com/smart-news/a-little-boys-library-book-was-due-in-1989-thirty-six-years-later-he-realized-his-parents-had-never-returned-it-180988046/ Baum, Stephanie. “Ancient parrot DNA reveals sophisticated, long-distance animal trade network pre-dating the Inca Empire.” 3/10/2026. https://phys.org/news/2026-03-ancient-parrot-dna-reveals-sophisticated.html Baum, Stephanie. “From the Late Bronze Age to today, the Old Irish Goat carries 3,000 years of Irish history.” 2/26/2026. https://phys.org/news/2026-02-late-bronze-age-today-irish.html Benzine, Vittoria. “What Did Pompeii Smell Like? 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DNA will determine if remains found are those of the famous musketeer.” El Pais. 3/25/2025. https://english.elpais.com/international/2026-03-25/is-dartagnan-lying-beneath-a-church-in-maastricht-dna-will-determine-if-remains-found-are-that-of-the-famous-musketeer.html?outputType=amp Gebauer, Kathryn. “Groundbreaking discovery reveals Africa’s oldest cremation pyre and complex ritual practices.” EurekAlert. 1/1/2016. https://www.eurekalert.org/news-releases/1111191 Harley, Sadie. “Iron Age dental plaque reveals Scythians consumed milk from horses and ruminants.” Phys.org. 1/21/2026. https://phys.org/news/2026-01-iron-age-dental-plaque-reveals.html He, Ye. “Singapore’s first ancient shipwreck reveals record cargo of Yuan dynasty blue-and-white porcelain.” EurekAlert. 2/12/2026. https://www.eurekalert.org/news-releases/1116512 Johansen, Rikke Tørnsø. “Archaeologists reveal a medieval super ship: "It's the World’s largest cog".” Vikingeskibs Museet. 12/22/2025. https://www.vikingeskibsmuseet.dk/en/news/archaeologists-reveal-a-medieval-super-ship-its-the-worlds-largest-cog Kasal, Krystal. “Hannibal's famous war elephants: Single bone in Spain offers first direct evidence.” Phys.org. 2/5/2026. https://phys.org/news/2026-02-hannibal-famous-war-elephants-bone.html Kasal, Krystal. “Oldest known sewn hide and other artifacts from Oregon caves shed light on early clothing in harsh climates.” Phys.org. 2/10/2026. https://phys.org/news/2026-02-oldest-sewn-artifacts-oregon-caves.html Killgrove, Kristina. “Romans used human feces as medicine 1,900 years ago — and used thyme to mask the smell.” 1/29/2026. https://www.livescience.com/archaeology/romans/romans-used-human-feces-as-medicine-1-900-years-ago-and-used-thyme-to-mask-the-smell Killgrove, Kristina. “Stone Age woman was buried like a man, revealing flexible gender roles 7,000 years ago in Hungary.” LiveScience. 3/3/2026. https://www.livescience.com/archaeology/stone-age-woman-was-buried-like-a-man-revealing-flexible-gender-roles-7-000-years-ago-in-hungary Koc University. “Earliest evidence of indigo-dyed textiles and single-needle knitting discovered in Bronze Age Anatolia.” Phys.org. 2/21/2026. https://phys.org/news/2026-02-earliest-evidence-indigo-dyed-textiles.html Kuta, Sarah. “Did Neanderthals Use Birch Bark Tar as an Antibiotic to Treat Wounds and Infections?” Smithsonian. 3/30/2026. https://www.smithsonianmag.com/smart-news/did-neanderthals-use-birch-bark-tar-as-an-antibiotic-to-treat-wounds-and-infections-180988393/ Kuta, Sarah. “Ostrich Eggshells Suggest Our Ancestors May Have Understood Basic Geometry 60,000 Years Ago.” Smithsonian. 3/9/2026. https://www.smithsonianmag.com/smart-news/these-intricately-decorated-ostrich-eggshells-suggest-our-ancestors-may-have-understood-basic-geometry-60000-years-ago-180988315/ Kuta, Sarah. “Ötzi the Iceman May Have Carried a Cancer-Causing Strain of HPV, a Common Virus Still Plaguing Humans Today.” Smithsonian. 1/20/2026. https://www.smithsonianmag.com/smart-news/otzi-the-iceman-may-have-carried-a-cancer-causing-strain-of-hpv-a-common-virus-still-plaguing-humans-today-180988024/ Kuta, Sarah. “Shipwreck Timbers Appeared on a Beach After a Storm. 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Maybe not, according to a new study.” Phys.org. 2/21/2026. https://phys.org/news/2026-02-men-genghis-khan.html Lucibella, Michael. “Prehistoric tool made from elephant bone is the oldest discovered in Europe.” EurekAlert. 1/26/2026. https://www.eurekalert.org/news-releases/1113140 Luscombe, Richard. “Mass grave in Jordan sheds new light on world’s earliest recorded pandemic.” The Guardian. 1/31/2026. https://www.theguardian.com/science/2026/jan/31/plague-of-justinian-pandemic net. “Did King Harold Sail to Hastings? New Study Sparks Debate Among Historians.” 3/2026. https://www.medievalists.net/2026/03/did-king-harold-sail-to-hastings-new-study-sparks-debate-among-historians/ net. “Viking-Age Woman Buried with Her Dog in Norway.” 3/2026. https://www.medievalists.net/2026/03/viking-age-woman-buried-with-her-dog-in-norway/ Newcastle University Press Office. “5,300-year-old ‘bow drill’ rewrites story of ancient Egyptian tools.” 2/9/2026. https://www.ncl.ac.uk/press/articles/latest/2026/02/ancientegyptiandrillbit/ Noraz, R., Chauvey, L., Wagner, S. et al. Ancient DNA reveals 4000 years of grapevine diversity, viticulture and clonal propagation in France. Nat Commun 17, 2494 (2026). https://doi.org/10.1038/s41467-026-70166-z Nordin, Gunilla. “World’s oldest arrow poison – 60,000-year-old traces reveal early advanced hunting techniques.” 1/7/2026. https://www.eurekalert.org/news-releases/1111624 Parco Archaeologico de Ercolano. “Archaeology: New precious decorations discovered at Villa Sora in the Herculaneum Park.” 2/5/2026. https://ercolano.cultura.gov.it/archaeology-new-precious-decorations-discovered-at-villa-sora-in-the-herculaneum-park/?lang=en Paul, Andrew. “Hiker finds 3,000-year-old bull sculpture in Spain.” Popular Science. 3/17/2026. https://www.popsci.com/science/hiker-finds-bronze-age-bull-spain/ Potter, Lisa. “A wild potato that changed the story of agriculture in the American Southwest.” EurekAlert. 1/21/2026. https://www.eurekalert.org/news-releases/1113056 “Digital scans unveil new love notes and sketches on ancient Pompeii wall.” 1/19/2026. https://www.reuters.com/science/digital-scans-unveil-new-love-notes-sketches-ancient-pompeii-wall-2026-01-19/ Richard L. Rosencrance et al. ,Complex perishable technologies from the North American Great Basin reveal specialized Late Pleistocene adaptations. Sci. Adv. 12, eaec2916(2026).DOI:10.1126/sciadv.aec2916 Ruse, Amy. “Tasmanian tiger lives on in Arnhem Land rock art.” EurekAlert. 3/30/2026. https://www.eurekalert.org/news-releases/1121955 Ruse, Amy. “World’s oldest rock art holds clues to early human migration to Australia.” EurekAlert. 1/21/2026. https://www.eurekalert.org/news-releases/1112900 Siehoff, Jonas. “Hygienic conditions in Pompeii's early baths were poor.” 1/12/2026. https://www.eurekalert.org/news-releases/1112403 Taçon, P. S. C., A.Jalandoni, S. K.May, J.Nganjmirra, and C.Mungulda. 2026. “The Devil Is in the Detail: Tasmanian Devil and Tasmanian Tiger Paintings From Awunbarna and Injalak Hill, Northern Territory, Australia.” Archaeology in Oceania. https://doi.org/10.1002/arco.70024 The History Blog. “$40 estate sale find by early African-American silversmith sells for $24,000.” 2/4/2026. https://www.thehistoryblog.com/archives/75294 The History Blog. “43,000 ostraca found at one site shed light on social history of Egypt.” 5/15/2026. https://www.thehistoryblog.com/archives/75609 The History Blog. “British Museum acquires Tudor Heart.” 2/10/2026. https://www.thehistoryblog.com/archives/75343 The History Blog. “Exceptional Roman cargo shipwreck found in Lake Neuchâtel.” 3/29/2026. https://www.thehistoryblog.com/archives/75705 The History Blog. “Extraordinary find: 10th c. bronze wheel cross matches mold found 43 years ago.” 1/24/2026. https://www.thehistoryblog.com/archives/75220 The History Blog. “Previously unknown Hans Baldung Grien portrait emerges after 500 years in the sitter’s family.” 1/17/2026. https://www.thehistoryblog.com/archives/75161 The History Blog. “Roman wooden writing tablets from Belgium deciphered.” 1/22/2206. https://www.thehistoryblog.com/archives/75207 Thomas, Laura. “A century-old Stonehenge mystery may finally be solved.” Science Daily. 1/27/2026. https://www.sciencedaily.com/releases/2026/01/260127010208.htm Thorsberg, Christian. “The National Gallery of Art Acquires 17th-Century Masterpiece by Baroque Painter Artemisia Gentileschi.” Smithsonian. 2/7/2026. https://www.smithsonianmag.com/smart-news/the-national-gallery-of-art-acquired-17th-century-masterpiece-by-baroque-painter-artemisia-gentileschi-180988147/ Thorsberg, Christian. “This Luxury Steamer Disappeared on a Stormy Night in 1872. Nearly 150 Years Later to the Day, It Was Found at the Bottom of Lake Michigan.” Smithsonian. 2/18/2026. https://www.smithsonianmag.com/smart-news/this-luxury-steamer-disappeared-on-a-stormy-night-in-1872-nearly-150-years-to-the-day-it-was-found-in-the-bottom-of-lake-michigan-180988204/ Unibo Magazine. “Humanity’s oldest geometries, engraved on ostrich eggs.” https://magazine.unibo.it/en/articles/humanitys-oldest-geometries-engraved-on-ostrich-eggs University of Tübingen. “Earliest hand-held wooden tools found in Greece date back 430,000 years.” Phys.org. 1/1/2026. https://phys.org/news/2026-01-earliest-held-wooden-tools-greece.html Villotte, S., T.Szeniczey, S.Kacki, and A.Anders. 2026. “Fixed and Fluid: The Two Faces of Gender Roles—A Combined Study of Activity Patterns and Burial Practices in the European Neolithic.” American Journal of Biological Anthropology189, no. 2: e70217. https://doi.org/10.1002/ajpa.70217. 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In this second deep dive episode, Cherry Lim discusses how complex modelling approaches can translate into practical clinical insights. From counterfactual frameworks to real-world prescribing decisions, she explores how data-driven tools can support clinicians in choosing more effective antibiotic treatments.  Timestamps 00:00 – Introduction 01:03 – Understanding counterfactual frameworks 02:56 – Antibiotic choice and survival 05:08 – Clinical decision dashboards 06:24 – Assumptions in AMR modelling

This is the first episode of the 'Quarterly catchup' series, in which CMI Communications editors discuss important and useful articles that have come out in the last 3 months to understand their results and potential clinical impact. In this inaugural episode of 'Quarterly catchup', Emily McDonald (Canada), Thomas Tängdén (Sweden) and Navaneeth Narayanan (USA) convene to discuss clinical microbiology and infectious diseases studies published in the first quarter of 2026 [1-6]. From Wolbachia-infected mosquitoes reducing dengue infection to exploration of antibiotic combination therapies against multidrug-resistant organisms, our hosts summarize six articles they found the most interesting, and discuss whether they can and should change clinical practice.   This episode was peer reviewed by Connor Prosty of McGill University, Montréal, Canada.  ReferencesLim JT, et al. Dengue suppression by Male Wolbachia-Infected mosquitoes. NEJM 2026. doi: https://doi.org/10.1056/NEJMoa2503304 Escrihuela-Vida F, et al. Adjunctive Fosfomycin for the Treatment of Staphylococcus aureus Bacteremia: A Pooled Post Hoc Analysis of Individual Participant Data From 2 Randomized Trial. Clin Infect Dis 2026. doi: https://doi.org/10.1093/cid/ciaf387 Baldanzi G, et al. Antibiotic use and gut microbiome composition links from individual-level prescription data of 14,979 individuals. Nat Med 2026. doi: https://doi.org/10.1038/s41591-026-04284-y.Quentin Vallé, et al. Evaluating the antibacterial activity of ceftazidime/avibactam and aztreonam combinations against multidrug-resistant Stenotrophomonas maltophilia complex isolates in a hollow fibre infection model.  Clin Microbiol Infect 2026. doi: https://doi.org/10.1016/j.cmi.2026.02.010 Rana AI, et al. Cabotegravir plus Rilpivirine for Persons with HIV and Adherence Challenges. NEJM 2026. doi: https://doi.org/10.1056/NEJMoa2508228 Donovan J, et al. Genotype-stratified adjunctive dexamethasone for tuberculous meningitis in HIV-negative adults: a randomized controlled phase 3 trial. Nat Med 2026. doi: https://doi.org/10.1038/s41591-025-04138-z Further readingThwaite GE, et al. Dexamethasone for the Treatment of Tuberculous Meningitis in Adolescents and Adults. NEJM 2004. doi: https://doi.org/10.1056/NEJMoa040573 Behrmann LV. “The specimen is never wrong”: the pathologist behind Wolbachia. CMI Communications, 2026. doi: https://doi.org/10.1016/j.cmicom.2026.105185                

Episode: 2687 Getting to know the organisms that live on and in the human body.  Today, what lives within us.

Antibiotic stewardship and infection prevention are critical in nursing homes, where residents are especially vulnerable and antibiotic overuse remains a persistent challenge. In this episode of The SHEA Podcast, host Kristy Weinshel is joined by Dr. Suzanne Bradley and Dr. Morgan Katz to discuss what nursing homes need to know to improve stewardship practices and resident safety. Together, they explore SHEA's “You Can Help! Improving Antibiotic Stewardship & Infection Prevention in Nursing Homes” program, including its practical, micro-learning approach designed for brief daily huddles. The conversation highlights how frontline staff—especially nurses and CNAs—can play a vital role in influencing antibiotic decisions, recognizing early signs of infection, and improving communication across care teams. They also address common misconceptions around urinary tract and respiratory infections, and explain how unnecessary antibiotic use contributes to multidrug-resistant organisms in long-term care settings. From early detection strategies to empowering staff engagement, this episode offers actionable insights for strengthening stewardship efforts and enhancing the quality and safety of care for nursing home residents. Check out SHEA's “You Can Help! Improving Antibiotic Stewardship & Infection Prevention in Nursing Homes” course here: https://learningce.shea-online.org/content/you-can-help-improving-antibiotic-stewardship-infection-prevention-nursing-homes#group-tabs-node-course-default1

In his weekly clinical update, Dr. Griffin and Vincent Racaniello talk about the resignation of a member of the advisory committee for immunization practices and the irony of his rationale that a judge slandered him, vaccinating dairy cattle against H5N1, illnesses resulting from drinking raw milk and the US norovirus outbreak, which is not cruise related, then Dr. Griffin deep dives into the measles outbreak in South Carolina and Utah, recent statistics RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, where to find PEMGARDA, safety data of the RSV vaccine for high risk young adults, recognition of unrecognized COVID-19 deaths (but weren't we not allow to call it a COVID-19 in 2020?), retraction of and how the ANTIBIOTIC azithromycin is NOT an antiviral drug, how to access and pay for Paxlovid, long COVID patients with neurocognitive symptoms and contacting your federal government representative to stop the assault on science and biomedical research. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Confusion abounds over future of US vaccine advisory committee (The Guardian) Key Adviser Quits Federal Vaccine Panel (NY Times) Vaccinate the vacca? …..Why We Must Vaccinate US Dairy Cattle Against HPAI H5N1(JID) Largest Animal Health Emergency in US History Continues as HPAI Hits Indiana Hard (Hoosier AG Today) Indiana: More than 350,000 birds killed in massive avian flu outbreak (CIDRAP) 5 children receive E. Coli from raw milk; TN dairy farm responds (Local 3 News) Quick takes: Measles spike in Utah, 5 kids ill from raw milk, CDC director uncertainty (CIDRAP) Increasing Predominance of Norovirus GII.17 over GII.4, United States, 2022–2025 (Emerging Infectious Diseases) Wastewater for norovirus (WasterWater Scan) Wastewater for measles (WasterWater Scan) Measles cases and outbreaks (CDC Rubeola) Big outbreak, bright lights…Measles Dashboard (South Carolina Department of Public Health) Utah measles outbreak response (Utah Department of Health and Human Services) Utah Measles Dashboard (Utah Department of Health and Human Services) Tracking Measles Cases in the U.S. (Johns Hopkins) Measles vaccine recommendations from NYP (jpg) Weekly measles and rubella monitoring (Government of Canada) Measles (WHO) Get the FACTS about measles (NY State Department of Health) Measles(CDC Measles (Rubeola)) Measles vaccine (CDC Measles (Rubeola)) Presumptive evidence of measles immunity (CDC) Contraindications and precautions to measles vaccination (CDC) Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) Deaths following vaccination: what does the evidence show (Vaccine) Influenza: Waste water scan for 11 pathogens (WastewaterSCan) US respiratory virus activity (CDC Respiratory Illnesses) Respiratory virus activity levels (CDC Respiratory Illnesses) Flu vaccine recommendations: Vaccines and Related Biological Products Advisory Committee March 12, 2026 Meeting Announcement (FDA) WHO updates all 3 viral strains to be included in fall flu shots(CIDRAP) Weekly surveillance report: clift notes (CDC FluView) OPTION 2: XOFLUZA $50 Cash Pay Option(xofluza) RSV: Waste water scan for 11 pathogens (WastewaterSCan) Respiratory Diseases (Yale School of Public Health) RSV-Network (CDC Respiratory Syncytial virus Infection) Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) Respiratory Diseases (Yale School of Public Health) Immunogenicity and Safety of the AS01E-adjuvanted Respiratory Syncytial Virus (RSV) Prefusion F Protein Vaccine in Adults Aged 18–49 Years at Increased Risk of RSV Disease Compared with Adults Aged ≥60 Years  (CID) Waste water scan for 11 pathogens (WastewaterSCan) COVID-19 deaths (CDC) Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) COVID-19 national and regional trends (CDC) COVID-19 variant tracker (CDC) SARS-CoV-2 genomes galore (Nextstrain) Respiratory viral infections prime accelerated lung cancer growth (Cell) Association between COVID-19 vaccination and sudden death in apparently healthy younger individuals: A population-based case-control study (PLoS Medicine) Applying machine learning to identify unrecognized COVID-19 deaths recorded as other causes of death in the United States (Science Advances) RETRACTED work: Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial (International Journal of Antimicrobial Agents) Antibiotic used in COVID patients tied to increased signs of antibiotic resistance (CIDRAP) Empiric azithromycin alters the upper respiratory microbiome and resistome without anti-inflammatory benefit in COVID-19 (Nature Microbiology) COVID-19 mRNA Vaccination in Pregnancy and Risk of Infection in Early Childhood (Pediatrics) Where to get pemgarda (Pemgarda) EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) Infusion center (Prime Fusions) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Drug interaction checker (University of Liverpool) Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) Understanding Coverage Options (PAXCESS) Infectious Disease Society guidelines for treatment and management (ID Society) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) What to do when sick with a respiratory virus (CDC) Managing healthcare staffing shortages (CDC) Anticoagulation guidelines (hematology.org) Daniel Griffin's evidence based medical practices for long COVID (OFID) Long COVID hotline (Columbia : Columbia University Irving Medical Center) The answers: Long COVID Outcomes of Patients with Neurocognitive Symptoms Attending a Long COVID Clinic: A Longitudinal Cohort Study (Journal of General Internal Medicine) Outcomes of Patients withNeurocognitive Symptoms Attending a Long COVID Clinic: A Longitudinal Cohort Study (Journal of General Internal Medicine) Long COVID Treatment Guide (rthm) Reaching out to US house representative Letters read on TWiV 1308 Dr. Griffin's COVID treatment summary (pdf) Timestamps by Jolene Ramsey. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv Content in this podcast should not be construed as medical advice.

Doctor and special correspondent Avir Mitra takes Executive Editor Soren Wheeler, plus a live studio audience, on a journey from the operating room to inside the body to the farm to the sewers and back again—searching for answers to an alarming threat to humanity's existence as we know it: antibiotic resistance in bacteria.  This live show, performed in New York City and also in Little Rock, Arkansas, is part of a series we're doing with Avir that we are calling “Viscera.” Each event is a conversation that takes the audience on a journey into a quirk or question or mystery inside of us, and gives them a visceral experience of the viscera within us. The previous installment of the series was called “The Elixir of Life.” (https://radiolab.org/podcast/the-elixir-of-life)Special thanks to all of Little Rock Public Radio (especially Grace Zafasi and Jonathan Seaborn), Thomas Patterson, The Greene Space staff, CALS Ron Robinson Theater, Tom Philpott, Stephen Roach, Kate Shaw, Alex Wong, Maryn McKenna, and Kerri McClimen.If you are a patients or a doctor, and you are interested in phage therapy, please contact IPATH@ucsd.edu EPISODE CREDITS:  Reported by - Avir Mitra Produced by - Jessica Yung Sound design contributed by - Jeremy Bloom and Jessica Yung Fact-checking by -Natalie Middleton EPISODE CITATIONS: Videos - Check out the video from the Viscera live show (and a bonus Q&A with Bruce Stewart-Brown and Steffanie Strathdee) on Radiolab's YouTube (https://zpr.io/3BK9MqJYVKQA). A deep dive (https://zpr.io/WNQNfgiNvKeZ) on bacteriophages with Avir Mitra and Steffanie Strathdee, also on Radiolab's Youtube.. Books - The Perfect Predator (https://theperfectpredator.com/) by Dr. Steffanie Strathdee's telling of her battle against a killer superbug. Plucked (https://zpr.io/PudGMEuzgU9X) by Maryn Mckenna a detailed accounting of chicken farming's practice of using antibiotics. Signup for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today. Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing radiolab@wnyc.org.Leadership support for Radiolab's science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

learn 10 high-frequency expressions, including medicine and medical supplies

When penicillin was first used as an antibiotic, it was considered a wonder drug. Infections which had been fatal for thousands of years were suddenly curable. Without antibiotics, I would not be here today, and many of you would not be reading this.Man has long known that some natural substances have a natural ability to fight infections. But recently modern medicine had to step aside and acknowledge that not all medical breakthroughs are made by doctors—or even human beings.For years, it has been known that the roots and leaves of the Apsilia shrub are used as a traditional African treatment for wound and stomach aches. Researchers also observed chimpanzees swallowing the leaves of the shrub. This led them to investigate more about the leaves. They learned that Aspilia leaves and roots contain a chemical which kills some infectious bacteria, as well as fungi and worms. Researchers hope to learn whether this chemical is safe and effective for humans when taken orally.However, the mystery remains. How did the chimps discover the antibiotic nature of Aspila? We need to look to our Creator Who appears to have given the chimps this knowledge. While disease and death are not part of His original design for the creation, He was loving enough to provide medicinal help for these consequences of human sin. But the permanent cure for sin and death began with the birth of His Son, Jesus Christ.Romans 8:20-21"For the creature was made subject to vanity, not willingly, but by reason of him who hath subjected the same in hope, Because the creature itself also shall be delivered from the bondage of corruption into the glorious liberty of the children of God."Prayer: Dear Father, disease and death were not Your plan for the creation, but the result of man's rebellion against You. Let the wide scope of Your mercy in providing us with some earthly remedies for the results of sin fill me with even greater appreciation for Your boundless mercy and love to us in Christ. In His Name. Amen.Image: Aspilia africana plant, Peter B. Phillipson, CC BY-SA 4.0, Wikimedia Commons + Aspilia africana flower closeup, Peter B. Phillipson.  To support this ministry financially, visit: https://www.oneplace.com/donate/1232/29?v=20251111

Simon Mills is one of the UK's leading medical herbalists and a pioneer of modern herbal medicine. In this moment, Simon explains why antibiotics aren't always the answer - and what traditional medicine has used for centuries instead. From the hidden risks of overusing antibiotics, to simple natural remedies you can make at home using plants, he reveals a completely different way of thinking about treatment. Listen to the full episode here: Spotify: https://g2ul0.app.link/RDxRs9U9m1b Apple: https://g2ul0.app.link/goByfXY9m1b Watch the Episodes On YouTube: https://www.youtube.com/c/%20TheDiaryOfACEO/videos Simon Mills: https://www.herbalreality.com/writer/simon-mills/

In the second deep dive, Matteo Bassetti examines antibiotic stewardship where policy meets practice. He highlights gaps between guidelines and bedside realities, practical interventions for limited-resource settings, and balancing preservation of new antibiotics with effective treatment today. Timestamps: 01:27 – Guideline gaps 04:40 – Encouraging stewardship 06:23 – Realistic interventions 09:59 – Antibiotic shortages 11:16 – Preserving new drugs

In the final deep dive, Matteo Bassetti discusses antimicrobial resistance beyond the bedside: translating evidence into policy, the importance of national surveillance, lessons from sepsis and COVID-19, and the future of antibiotic innovation and hospital preparedness. Timestamps: 01:24 – Translating evidence into policy 02:54 – National surveillance 04:15 – Sepsis and COVID-19 06:18 – Investment shortfalls 08:41 – Antibiotic crisis 10:19 – Looking ahead

About this episode: Dentists prescribe about 10% of all antibiotics in the U.S., but research shows that a large share may be unnecessary. In this episode: the grave public health risks of inappropriate antibiotic use, how this can be curbed, and the questions you should ask next time you're in the dentist's chair. Guest: Liz Szabo, MA, is an investigative health reporter with CIDRAP News. Host: Dr. Josh Sharfstein is distinguished professor of the practice in Health Policy and Management, a pediatrician, and former secretary of Maryland's Health Department. Show links and related content: Antibiotic Aftershocks—CIDRAP News Evidence-based clinical practice guideline on antibiotic use for the urgent management of pulpal- and periapical-related dental pain and intraoral swelling—JADA Assessment of the Appropriateness of Antibiotic Prescriptions for Infection Prophylaxis Before Dental Procedures, 2011 to 2015—JAMA A Second, Silent Pandemic: Antibiotic Resistance—Global Health Now Transcript information: Looking for episode transcripts? Open our podcast on the Apple Podcasts app (desktop or mobile) or the Spotify mobile app to access an auto-generated transcript of any episode. Closed captioning is also available for every episode on our YouTube channel. Contact us: Have a question about something you heard? Looking for a transcript? Want to suggest a topic or guest? Contact us via email or visit our website. Follow us: @‌PublicHealthPod on Bluesky @‌PublicHealthPod on Instagram @‌JohnsHopkinsSPH on Facebook @‌PublicHealthOnCall on YouTube Here's our RSS feed Note: These podcasts are a conversation between the participants, and do not represent the position of Johns Hopkins University.

Listener advisory: This episode includes discussion of suicide.Many people with Multiple Chemical Sensitivity (MCS) trace the start of their illness to exposures like pesticides, fragrances, mold, smoke, or chemical fumes.Others say their symptoms began after taking prescription medications, especially antibiotics.In this episode, Dr. Stefan Pieper, a functional medicine physician in Germany who specializes in mitochondrial medicine, discusses Fluoroquinolone-Associated Disability (FQAD).People with the condition develop long-lasting neurological, cognitive, and physical symptoms after taking fluoroquinolone antibiotics. Some also develop chemical intolerance that closely resembles MCS.Could medications trigger long-term chemical sensitivity? And what might this reveal about MCS?Listen now:https://www.chemicalsensitivitypodcast.org/1970633/episodes/18803337-antibiotic-injury-mcs-dr-stefan-pieperWatch on YouTube:Link to come.The podcast has a new webpage!http://listen.chemicalsensitivitypodcast.org/Please share with anyone interested in learning more about MCS.  Link:Stefan Pieper — Fluoroquinolone-Associated Disability (FQAD): Side-effects of FluoroquinolonesSpringer Nature, 2026https://doi.org/10.1007/978-3-662-72123-0DISCLAIMER: THIS WEBSITE DOES NOT PROVIDE MEDICAL ADVICE  The information, including but not limited to, text, graphics, images, and other material contained on this website are for informational purposes only. No material on this site is intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read on this website. No material or information provided by The Chemical Sensitivity Podcast, or its associated website is intended to be a substitute for professional medical advice, diagnosis, or treatment. Support the showThank you very much to the Marilyn Brachman Hoffman Foundation generously supporting the podcast!If you find the podcast helpful, please consider becoming a supporter!https://buymeacoffee.com/mcspodcast Follow the podcast on YouTube! Captions available in any language. Please follow the podcast on social media:FacebookXInstagramBlueSkyTikTok

1.      In this first deep dive, Bassetti discusses the changing landscape of antimicrobial resistance in hospitals and ICUs, the challenges of multidrug-resistant Gram-negative bacteria, and the vulnerability of patients who are critically ill and immunocompromised. He explores how diagnosis, empiric therapy, and therapeutic monitoring influence outcomes and resistance. Timestamps: 01:09 – Antimicrobial resistance trends 04:06 – Tackling sepsis 06:39 – Gram-negative threat 08:15 – Vulnerable populations 10:00 – Diagnosis and empiric therapy 12:14 – Dosing and pharmacokinetics 14:32 – Antibiotic allergies

Non-Antibiotic Drugs Found to Harm Gut Flora Revitalize Your Gut: How Prebiotics, Probiotics & Postbiotics Work TogetherHow Vaccines Affect your Gut Flora https://www.georgebatista.com Spectrum Vibrance: https://collabs.shop/s0emjo The Wellness Company - https://www.twc.health/Batista Wellness Resources - http://www.myvitaminresource.com (Promocode: counterparts - For free shipping) https://rumble.com/user/CounterpartsShow https://www.instagram.com/georgebatistajr/ https://open.spotify.com/show/5MvjsMT... https://apple.co/3H39DGK Email:Wellnesstalk@protonmail.com Wellness Resources Since 1985, Wellness Resources has used only the highest quality nutrients, no chemical additives, t Disclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you. Support the showDisclaimer: The Wellness Talk podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions. Wellness Talk with George Batista

Non-Antibiotic Drugs Found to Harm Gut Flora Revitalize Your Gut: How Prebiotics, Probiotics & Postbiotics Work TogetherHow Vaccines Affect your Gut Flora https://www.georgebatista.com Spectrum Vibrance: https://collabs.shop/s0emjo The Wellness Company - https://www.twc.health/Batista Wellness Resources - http://www.myvitaminresource.com (Promocode: counterparts - For free shipping) https://rumble.com/user/CounterpartsShow https://www.instagram.com/georgebatistajr/ https://open.spotify.com/show/5MvjsMT... https://apple.co/3H39DGK Email:Wellnesstalk@protonmail.com Wellness Resources Since 1985, Wellness Resources has used only the highest quality nutrients, no chemical additives, t Disclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you. Support the showDisclaimer: The Wellness Talk podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions. Wellness Talk with George Batista

The soil sample was collected in a remote Indonesian jungle by a Christian missionary. A few grams of dirt scooped into a sample bag and shipped to the United States. Little did anyone know what those few grams would contain. A drug so special that its Chinese characters literally mean “The Antibiotic of the Ages”. It has been nearly 70 years since its market entry. In today's video, I want to pay tribute to an iconic compound. The unique, mysterious, infuriating but life-saving antibiotic: Vancomycin. For over three decades, our drug of last resort.

The soil sample was collected in a remote Indonesian jungle by a Christian missionary. A few grams of dirt scooped into a sample bag and shipped to the United States. Little did anyone know what those few grams would contain. A drug so special that its Chinese characters literally mean “The Antibiotic of the Ages”. It has been nearly 70 years since its market entry. In today's video, I want to pay tribute to an iconic compound. The unique, mysterious, infuriating but life-saving antibiotic: Vancomycin. For over three decades, our drug of last resort.

In this second deep dive, Glenda Gray examines why the global antibiotic pipeline is failing and how access gaps are fuelling resistance. She discusses GARDP's mission-driven research and development model, the neglect of paediatric antibiotics, and how shortages of first-line treatments drive reliance on last-resort drugs, worsening the antimicrobial resistance crisis. Timestamps: 00:00 – Introduction 00:58 – Antibiotic development 03:05 – GARDP's model 04:15 – Paediatric antibiotics 04:58 – Antibiotic shortages 05:50 – Access gaps

hear about it constantly. Some swear it cures "incurable" conditions. Others dismiss it entirely: "Just a useless grandma's remedy." Some even warn about serious allergic risks. So — who should we believe? Today the journalist who's done a deep dive on propolis.  Plus more Attia/Epstein updates  Valerie Orsoni is an OG biohacker and the author 55 books + keynote speaker. Follow her here.                Welcome inside the hive. Full breakdown.

On this episode of the ASHE Podcast, hosts Dr. Gonzalo Bearman and Dr. Priya Nori speak with Dr. Brittany Lehrer, and Dr. Sophie Katz, about their new study in ASHE, “It’s QuizTime! The impact of web-based microlearning quizzes on guideline-concordant antibiotic duration for pediatric acute otitis media.” They explore the prescribing gap in pediatric acute otitis media that inspired their microlearning approach and discuss why brief, web-based quizzes can be a high-yield stewardship tool in busy outpatient settings. The authors highlight key design elements that drove engagement, share surprising findings from their pre/post evaluation of guideline-concordant antibiotic duration, and offer practical advice for institutions looking to replicate this low-burden, scalable intervention to improve antibiotic prescribing. https://www.cambridge.org/core/journals/antimicrobial-stewardship-and-healthcare-epidemiology/article/its-quiztime-the-impact-of-webbased-microlearning-quizzes-on-guidelineconcordant-antibiotic-duration-for-pediatric-acute-otitis-media/C23CBF28D3DBA0985491820A5DC52382#article

Antibiotic use has been linked to higher anxiety and depression risk by disrupting gut bacteria that regulate brain chemistry and stress response Human studies show antibiotics lower key calming neurotransmitters and activate inflammatory brain cells tied to anxious behavior Repeated or early-life antibiotic exposure increases long-term vulnerability to anxiety, depression, and cognitive strain Antibiotics disrupt gut-brain signaling in ways that trigger anxiety, sleep problems, and emotional instability even in people with no prior mental health history Reducing unnecessary antibiotic use and restoring gut stability helps calm anxiety by addressing the biological cause rather than masking symptoms

Four years after our original antibiotic myth-busting episode (Ep 60), we're back with Dr Riati Scarborough to talk antibiotic prescribing habits. This time we're joined by fellow stewardship expert Dr Laura Hardefeldt, and this time we're asking the harder question: Have we actually changed?The good news? Some prescribing habits are shifting. We're seeing shorter courses and less ‘just in case antibiotic usage. But let's not pat ourselves on the back too quickly. Because some of our most entrenched habits are still alive and well, like how we treat skin disease, and our ongoing love affair with amoxiclav.This episode is a practical, clinically grounded update on what the evidence says in 2026 - and how to make realistic changes without compromising patient care.We cover:Why skin disease remains the single biggest driver of antimicrobial resistance in small animal practice, and what to do about itAmoxicillin vs amoxiclav: when de-escalation is not just safe, but smarterWhy convenience (you know the brand we're talking about right…) is not a clinical indicationTrimethoprim-sulphonamide and the real story on KCS riskDentals, heart murmurs, and what prophylaxis actually looks like in 2026Simple in-clinic stewardship strategies that genuinely shift prescribing behaviourThis isn't about perfection. It's about progress.If you'd like effective antibiotics to still exist in five to ten years…This episode is essential listening.Find out how we can support you in your vet career at ⁠⁠⁠⁠⁠⁠⁠thevetvault.com⁠⁠⁠⁠⁠⁠⁠.⁠Subscribe to our weekly newsletter⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠here⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠for Hubert's favourite clinical and non-clinical learnings from the week.Grab one last handful of spots in the Maldives for our surf/dive vet conference with ⁠Vets On Tour⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Tips and Timestamps3:03 Progress in prescribing habits including UTI durations and surgical prophylaxis4:55 Skin disease as the biggest problem area in small animal practice7:01 Topical therapy versus systemic antibiotics for skin conditions9:28 Deep pyoderma and the new consensus statement11:00 Gut bacteria as a source of resistant infections12:41 Rise of MRSP, methicillin-resistant Staphylococcus pseudintermedius14:00 Amoxicillin-clavulanate overuse16:47 Vets on Tour conferences advertisement18:08 Pharmacology refresher on amoxicillin, amoxicillin-clavulanate, and cefovecin19:45 Why cefovecin is classified as high importance, vs the convenience argument for cefovecin in cats22:56 Long-acting amoxicillin injections as an alternative24:00 Getting amoxicillin back on the shelf24:53 Communicating antibiotic choices to clients29:32 Dental antibiotics and debunking the heart murmur myth34:07 Subclinical bacteriuria and stopping cultures in asymptomatic patients38:30 Reassessing the dry eye risk of trimethoprim-sulfonamide41:43 Antimicrobial stewardship trial using colour-coded pharmacy shelves

Repeated or aggressive antibiotic use disrupts gut microbes that regulate brain chemicals, which raises your risk of anxiety, low mood, poor sleep, and emotional instability Research shows that antibiotics lower acetylcholine, a key neurotransmitter that supports calm focus, memory, and stress tolerance, explaining why many people feel anxious, foggy, or irritable after a course Even a single round of antibiotics is linked to higher rates of anxiety and depression, and the risk rises further with repeated exposure, especially with drugs like penicillin, quinolones, and clindamycin Antibiotic-driven gut damage weakens the gut barrier, reduces short-chain fatty acids, and overstimulates the stress-response system, creating a full-body shift that pushes the brain toward anxiety and depressive patterns Early-life antibiotic exposure leaves long-term marks on mood, behavior, and stress resilience, meaning gut disruption during childhood or adolescence can shape mental health well into adulthood

The Predator's Playbook: How To Identify And Prevent Child Sexual AbuseChild abuse is a sobering reality often perpetrated by trusted individuals rather than strangers. To successfully exploit a child, predators rely on a specific playbook to gain access, trust, and secrecy. Our expert this week explains how parents can help dismantle these opportunities without needing to resort to overprotective parenting styles.Guests: Dr. Bronwen Carroll, pediatric emergency medicine physician, Boston Medical Center, assistant professor of pediatrics, Boston UniversityHost: Elizabeth WestfieldProducer: Polly Hansen  Why Are Kidney Stones Skyrocketing In Young Girls?Kidney stones, historically associated with middle-aged men, are now being diagnosed at an increasing rate in young girls. Though stones can remain undetected for years, they often cause extreme pain and nausea once they move into the ureter. Our expert discusses treatment options and possible reasons we're seeing more cases in younger patients.  Guests: Dr. Greg Tasain, attending pediatric urologist, Children's Hospital of Philadelphia, professor of surgery, University of Pennsylvania Perelman School of Medicine  Host: Greg JohnsonProducers: Kristen Farrah Medical Notes: The Shocking Veteran Suicide Trends, The Best Time To Induce Labor, And The Mental Health Of College StudentsThe tides may finally be turning on veteran suicide. A new treatment for seizures may soon be possible without the need for invasive brain surgery. When it comes to inducing labor, success may be all in the timing. The stigma surrounding mental health on campus is fading. Host: Maayan Voss de Bettancourt Producer: Kristen Farrah Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Why Are Kidney Stones Skyrocketing In Young Girls?Kidney stones, historically associated with middle-aged men, are now being diagnosed at an increasing rate in young girls. Though stones can remain undetected for years, they often cause extreme pain and nausea once they move into the ureter. Our expert discusses treatment options and possible reasons we're seeing more cases in younger patients.  Guest: Dr. Greg Tasain, attending pediatric urologist, Children's Hospital of Philadelphia, professor of surgery, University of Pennsylvania Perelman School of Medicine Host: Greg Johnson  Producers: Kristen Farrah Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Send us a textIn this episode of Journal Club, Ben and Daphna dive into a multicenter retrospective study from the European Journal of Pediatrics questioning the necessity of universal empiric antibiotics in neonates undergoing therapeutic hypothermia for HIE. Comparing Italian and Belgian cohorts, the team discusses the reality of a 111 Number Needed to Treat (NNT) for a single case of culture-proven sepsis. From the diagnostic challenges of overlapping clinical markers to the fascinating "asymptote" of postnatal leukocyte trends, we explore whether it's time to shift from routine to selective antibiotic use in our most complex patients.----Antibiotic use in neonates with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia: time to rethink universal empirical treatment. De Rose DU, Piersigilli F, Auriti C, Campi F, Cortazzo V, Samaey A, Carkeek K, Martini L, Maddaloni C, Santisi A, Ronci S, Iacona G, Bersani I, Savarese I, Danhaive O, Cilio MR, Bernaschi P, Dotta A, Ronchetti MP.Eur J Pediatr. 2025 Nov 22;184(12):781. doi: 10.1007/s00431-025-06652-1.PMID: 41275063Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

When are antibiotics truly indicated in dentistry? How do you manage the patient who's begging for a prescription? And what impact are we having on the gut every time we prescribe unnecessarily? In this episode, Dr. Jeremy Lenaerts joins Jaz to explore the world of antibiotics in dentistry. Together, they cover when to prescribe, when not to, and why analgesics or local measures are often the better option. They also dive into the bigger picture—antibiotic resistance, gut health, and how to navigate those tricky conversations when patients demand antibiotics for the wrong reasons. https://youtu.be/-Q4hvl-8vpU Watch PDP254 on Youtube Protrusive Dental Pearl? Save time and avoid confusion with a ready-made Antibiotics Cheat Sheet that combines the best guidelines into one resource. It covers: True indications and contraindications Drug interactions First, second, and third-line choices Doses and duration

When should an antibiotic allergy actually be tested? In this episode of the BackTable ENT Podcast, guest host Dr. Basil Kahwash, an allergist and immunologist at Ohio ENT & Allergy, sits down with Dr. Cosby Stone, an allergist and immunologist at Vanderbilt University Medical Center, to discuss antibiotic allergies and how to distinguish true allergies from intolerances. --- SYNPOSIS Dr. Stone breaks down common misconceptions around antibiotic allergies, with a focus on penicillin and cephalosporins. The conversation explores how these allergies are evaluated, including when skin testing is appropriate, why inaccurate allergy labels matter, and how confirmed allergies should be managed long term. They also dive into more advanced topics such as drug desensitization, current research in the field, and where the future of drug allergy evaluation is headed. --- TIMESTAMPS 00:00 - Introduction 01:03 - Understanding Antibiotic Allergies07:28 - The Importance of Accurate Allergy Diagnosis10:55 - Key Questions for Diagnosing Allergies17:10 - Implementing Allergy Testing in Healthcare Settings19:06 - Identifying Severe Allergic Reactions26:31 - Interpreting Allergy Skin Testing Procedures33:17 - Penicillin and Cephalosporin Cross-Reactivity37:15 - Drug Desensitization: Indications and Process40:30 - Prognosis and Long-Term Outcomes of Drug Allergies47:22 - Conclusion and Final Thoughts --- RESOURCES Dr. Basil Kahwash https://www.ohioentandallergy.com/physicians/basil-kahwash-md/ Dr. Cosby Stonehttps://www.vanderbilthealth.com/doctors/stone-cosby

Dr. DebWhat if I told you that the stomach acid medication you’re taking for heartburn is actually causing the problem it’s supposed to solve that your doctor learned virtually nothing about nutrition, despite spending 8 years in medical school. That the very system claiming to heal you was deliberately designed over a hundred years ago by an oil tycoon, John D. Rockefeller, to create lifelong customers, not healthy people. Last week a patient spent thousands of dollars on tests and treatments for acid reflux, only to discover she needed more stomach acid, not less. The medication keeping her sick was designed to do exactly that. Today we’re exposing the greatest medical deception in modern history, how a petroleum empire systematically destroyed natural healing wisdom turned medicine into a profit machine. And why the treatments, keeping millions sick were engineered that way from the beginning. This isn’t about conspiracy theories. This is a documented history that explains why you feel so lost about your own body’s needs welcome back to let’s talk wellness. Now the show where we uncover the root causes of chronic illness, explore cutting edge regenerative medicine, and empower you with the tools to heal. I’m Dr. Deb. And today we’re diving into how the Rockefeller Medical Empire systematically destroyed natural healing wisdom and replaced it with profit driven systems that keeps you dependent on treatments instead of achieving true health. If you or someone you love has been running to the doctor for every minor ailment, taking acid blockers that seem to make digestive problems worse, or feeling confused about basic body functions that our ancestors understood instinctively. This episode is for you. So, as usual, grab a cup of coffee, tea, or whatever helps you unwind. Settle in and let’s get started on your journey to reclaiming your health sovereignty all right. So here we are talking about the Rockefeller Medical Revolution. Now, what if your symptoms aren’t true diagnosis, but rather the predictable result of a medical system designed over a hundred years ago to create lifelong customers instead of healthy people. Now I learned this when I was in naturopathic school over 20 years ago. And it hasn’t been talked about a lot until recently. Recently. People are exposing the truth about what actually happened in our medical system. And today I want to take you back to the early 19 hundreds to understand how we lost the basic health wisdom that sustained humanity for thousands of years. Yes, I said that thousands of years. This isn’t conspiracy theory. This is documented history. That explains why you feel so lost when it comes to your own body’s needs. You know by the turn of the 20th century. According to meridian health Clinic’s documentation. Rockefeller controlled 90% of all petroleum refineries in America and through ownership of the Standard Oil Corporation. But Rockefeller saw an opportunity that went far beyond oil. He recognized that petrochemicals could be the foundation for a completely new medical system. And here’s what most people don’t know. Natural and herbal medicines were very popular in America during the early 19 hundreds. According to Staywell, Copper’s historical analysis, almost one half of medical colleges and doctors in America were practicing holistic medicine, using extensive knowledge from Europe and native American traditions. People understood that food was medicine, that the body had natural healing mechanisms, and that supporting these mechanisms was the key to health. But there was a problem with the Rockefeller’s business plan. Natural medicines couldn’t be patented. They couldn’t make a lot of money off of them, because they couldn’t hold a patent. Petrochemicals, however, could be patented, could be owned, and could be sold for high profits. So Rockefeller and Andrew Carnegie devised a systematic plan to eliminate natural medicine and replace it with petrochemical based pharmaceuticals and according to E. Richard Brown’s comprehensive academic documentation in Rockefeller, medicine men. Medicine, and capitalism in America. They employed the services of Abraham Flexner, who proceeded to visit and assess every single medical school in us and in Canada. Within a very short time of this development, medical schools all around the us began to collapse or consolidate. The numbers are staggering. By 1910 30 schools had merged, and 21 had closed their doors of the 166 medical colleges operating in 19 0, 4, a hundred 33 had survived by 1910 and a hundred 4 by 1915, 15 years later, only 76 schools of medicine existed in the Us. And they all followed the same curriculum. This wasn’t just about changing medical education. According to Staywell’s copper historical analysis. Rockefeller and Carnegie influenced insurance companies to stop covering holistic treatments. Medical professionals were trained in the new pharmaceutical model and natural solutions became outdated or forgotten. Not only that alternative healthcare practitioners who wanted to stay practicing in alternative medicine were imprisoned for doing so as documented by the potency number 710. The goal was clear, create a system where scientists would study how plants cure disease, identify which chemicals in the plants were effective and then recreate a similar but not identical chemical in the laboratory that would be patented. E. Richard Brown’s documents. The story of how a powerful professional elite gained virtual homogeny in the western theater of healing by effectively taking control of the ethos and practice of Western medicine. The result, according to the healthcare spending data, the United States now spends 17.6% of its Gdp on health care 4.9 trillion dollars in 2023, or 14,570 per person nearly twice as much as the average Oecd country. But it doesn’t focus on cure. But on symptoms, and thus creating recurring clients. This systematic destruction of natural medicine explains why today’s healthcare providers often seem baffled by simple questions about nutrition why they immediately reach for a prescription medication for minor ailments, and why so many people feel disconnected from their own body’s wisdom. We’ve been trained over 4 generations to believe that our bodies are broken, and that symptoms are diseases rather than messages, and that external interventions are always superior to supporting natural healing processes. But here’s what they couldn’t eliminate your body’s innate wisdom. Your digestive system still functions the same way it did a hundred years ago. Your immune system still follows the same patterns. The principles of nutrition, movement and stress management haven’t changed. We’ve just forgotten how to listen and respond. We’re gonna take a small break here and hear from our sponsor. When we come back. We’re gonna talk about the acid reflux deception, and why your cure is making you sicker, so don’t go away all right, welcome back. So I want to give you a perfect example of how Rockefeller medicine has turned natural body wisdom upside down, the treatment of acid, reflux, and heartburn. Every single day in my practice I see patients who’ve been taking acid blocker medications, proton pump inhibitors like prilosec nexium or prevacid for years, not for weeks, years, and sometimes even decades. They come to me because their digestive problems are getting worse, not better. They have bloating and gas and nutrition deficiencies. And we’re seeing many more increased food sensitivities. And here’s what’s happening in the Us. Most people often attribute their digestive problems to too much stomach acid. And they use medications to suppress the stomach acid, but, in fact symptoms of chronic acid, reflux, heartburn, or gerd, can also be caused by too little stomach acid, a condition called hyper. Sorry hypochlorhydria normal stomach acid has a Ph level of one to 2, which is highly acidic. Hydrochloric acid plays an important role in your digestion and your immunity. It helps to break down proteins and absorb essential nutrients, and it helps control viruses and bacteria that might otherwise infect your stomach. But here’s the crucial part that most people don’t understand, and, according to Cleveland clinic, your stomach secretes lower amounts of hydrochloric acid. As you age. Hypochlorhydria is more common in people over the age of 40, and even more common over the age of 65. Webmd states that the stomach acid can produce less acid as a result of aging and being 65 or older is a risk factor for developing hypochlorhydria. We’ve been treating this in my practice for a long time. It’s 1 of the main foundations that we learn as naturopathic practitioners and as naturopathic doctors, and there are times where people need these medications, but they were designed to be used short term not long term in a 2,013 review published in Medical News today, they found that hypochlorhydria is the main change in the stomach acid of older adults. and when you have hypochlorydria, poor digestion from the lack of stomach, acid can create gas bubbles that rise into your esophagus or throat, carrying stomach acid with them. You experience heartburn and assume that you have too much acid. So you take acid blockers which makes the underlying problem worse. Now, here’s something that will shock you. PPI’s protein pump inhibitors were originally studied and approved by the FDA for short-term use only according to research published in us pharmacists, most cases of peptic ulcers resolve in 6 to 8 weeks with PPI therapy, which is what these medications were created for. Originally the American family physician reports that for erosive esophagitis. Omeprazole is indicated for short term 4 to 8 weeks. That’s it. Treatment and healing and done if needed. An additional 4 to 8 weeks of therapy may be considered and the University of Minnesota College of Pharmacy, States. Guidelines recommended a treatment duration of 8 weeks with standard once a day dosing for a PPI for Gerd. The Canadian family physician, published guidelines where a team of healthcare professionals recommended prescribing Ppis in adults who suffer from heartburn and who have completed a minimum treatment of 4 weeks in which symptoms were relieved. Yet people are taking these medications for years, even decades far beyond their intended duration of use and a study published in Pmc. Found that the threshold for defining long-term PPI use varied from 2 weeks to 7 years of PPI use. But the most common definition was greater than one year or 6 months, according to the research in clinical context, use of Ppis for more than 8 weeks could be reasonably defined as long-term use. Now let’s talk about what these acid blocker medications are actually doing to your body when used. Long term. The research on long term PPI use is absolutely alarming. According to the comprehensive review published in pubmed central Pmc. Long-term use of ppis have been associated with serious adverse effects, including kidney disease, cardiovascular disease fractures because you’re not absorbing your nutrients, and you’re being depleted. Infections, including C. Diff pneumonia, micronutrient deficiencies and hypomagnesium a low level of magnesium anemia, vitamin, b, deficiency, hypocalcemia, low calcium, low potassium. and even cancers, including gastric cancer, pancreatic cancer, colorectal cancer. And hepatic cancer and we are seeing all of these cancers on a rise, and we are now linking them back to some of these medications. Mayo clinic proceedings published research showing that recent studies regarding long-term use of PPI medication have noted potential adverse effects, including risks of fracture, pneumonia, C diff, which is a diarrhea. It’s a bacteria, low magnesium, low b 12 chronic kidney disease and even dementia. And a 2024 study published in nature communications, analyzing over 2 million participants from 5 cohorts found that PPI use correlated with increased risk of 15 leading global diseases, such as ischemic heart disease. Diabetes, respiratory infections, chronic kidney disease. And these associations showed dose response relationships and consistency across different PPI types. Now think about this. You take a medication for heartburn that was designed for 4 to 8 weeks of use, and when used long term, it actually increases your risk of life, threatening infections, kidney disease, and dementia. This is the predictable result of suppressing a natural body function that exists for important reasons. Hci plays a key role in many physiological processes. It triggers, intestinal hormones, prepares folate and B 12 for absorption, and it’s essential for absorption of minerals, including calcium, magnesium, potassium, zinc, and iron. And when you block acid production, you create a cascade of nutritional deficiencies and immune system problems that often manifest as seemingly unrelated health issues. So what’s the natural approach? Instead of suppressing stomach acid, we need to support healthy acid production and address the root cause of reflux healthcare. Providers may prescribe hcl supplements like betaine, hydrochloric acid. Bhcl is what it’s called. Sometimes it’s called betaine it’s often combined with enzymes like pepsin or amylase or lipase, and it’s used to treat hydrochloric acid deficiency, hypochlorhydria. These supplements can help your digestion and sometimes help your stomach acid gradually return back to normal levels where you may not need to use them all the time. Simple strategies include consuming protein at the beginning of the meal to stimulate Hcl production, consume fluids separately at least 30 min away from meals, if you can, and address the underlying cause like chronic stress and H. Pylori infections. This is such a sore subject for me. So many people walk around with an H. Pylori infection. It’s a bacterial infection in the stomach that can cause stomach ulcers, causes a lot of stomach pain and burning. and nobody is treating the infection. It’s a bacterial infection. We don’t treat this anymore with antibiotics or antimicrobials. We treat it with Ppis. But, Ppis don’t fix the problem. You have to get rid of the bacteria once the bacteria is gone, the gut lining can heal. Now it is a common bacteria. It can reoccur quite frequently. It’s highly contagious, so you can pick it up from other people, and it may need multiple courses of treatment over a person’s lifetime. But you’re actually treating the problem. You’re getting rid of the bacteria that’s creating the issue instead of suppressing the acid. That’s not fixing the bacteria which then leads to a whole host of other problems that we just talked about. There are natural approaches to increase stomach acid, including addressing zinc deficiency. And since the stomach uses zinc to produce Hcl. Taking probiotics to help support healthy gut bacteria and using digestive bitters before meals can be really helpful. This is exactly what I mean about reclaiming the body’s wisdom. Instead of suppressing natural functions, we support them instead of creating drug dependency, we restore normal physiology. Instead of treating symptoms indefinitely, we address the root cause and help the body heal itself. In many cultures. Bitters is a common thing to use before or after a meal. But yet in the American culture we don’t do that anymore. We’ve not passed on that tradition. So very few people understand how to use bitters, or what bitters are, or why they’re important. And these basic things that can be used in your food and cooking and taking could replace thousands of dollars of medication that you don’t really need. That can create many more problems along the way. Now, why does your doctor know nothing about nutrition. Well, I want to address something that might shock you all. The reason your doctor seems baffled when you ask about nutrition isn’t because they’re not intelligent. It’s because they literally never learned this in medical school statistics on nutritional education in medical schools are staggering and help explain why we have such a health literacy crisis in America. According to recent research published in multiple academic journals, only 27% of Us. Medical schools actually offer students. The recommended 25 h of nutritional training across 4 years of medical school. That means 73% of the medical schools don’t even meet the minimum standards set in 1985. But wait, it gets worse. A 2021 survey of medical schools in the Us. And the Uk. Found that most students receive an average of only 11 h of nutritional training throughout their entire medical program. and another recent study showed that in 2023 a survey of more than a thousand Us. Medical students. About 58% of these respondents said they received no formal nutritional education while in medical school. For 4 years those who did averaged only 3 h. I’m going to say this again because it’s it’s huge 3 h of nutritional education per year. So let me put this in perspective during 4 years of medical school most students spend fewer than 20 h on nutrition that’s completely disproportionate to its health benefits for patients to compare. They’ll spend hundreds of hours learning about pharmaceutical interventions, but virtually no time learning how food affects health and disease. Now, could this be? Why, when we talk about nutrition to lower cholesterol levels or control your diabetes, they blow you off, and they don’t answer you. It’s because they don’t understand. But yet what they’ll say is, people won’t change their diet. That’s why you have to take medication. That’s not true. I will tell you. I work with people every single day who are willing to change their diet. They’re just confused by all the information that’s out there today about nutrition. And what diet is the right diet to follow? Do I do, Paleo? Do I do? Aip? Do I do carnivore? Do I do, Keto? Do I do? Low carb? There’s so many diets out there today? It’s confusing people. So I digress. But let’s go back. So here’s the kicker. The limited time medical students do spend on nutrition office often focuses on nutrients think proteins and carbohydrates rather than training in topics such as motivational interviewing or meal planning, and as one Stanford researcher noted, we physicians often sound like chemists rather than counselors who can speak with patients about diet. Isn’t that true? We can speak super high level up here, but we can’t talk basics about nutrition. And this explains why only 14% of the physicians believe they were adequately trained in nutritional counseling. Once they entered practice and without foundational concepts of nutrition in undergrad work. Graduate medical education unsurprisingly falls short of meeting patients, needs for nutritional guidance in clinical practice, and meanwhile diet, sensitive chronic diseases continue to escalate. Although they are largely preventable and treatable by nutritional therapies and dietary. Lifestyle changes. Now think about this. Diet. Related diseases are the number one cause of death in the Us. The number one cause. Yet many doctors receive little to no nutritional education in medical school, and according to current health statistics from 2017 to march of 2020. Obesity prevalence was 19.7% among us children and adolescents affecting approximately 14.7 million young people. About 352,000 Americans, under the age of 20, have been diagnosed with diabetes. Let me say this again, because these numbers are astounding to me. 352,000 Americans, under the age of 20, have been diagnosed with diabetes with 5,300 youth diagnosed with type, 2 diabetes annually. Yet the very professionals we turn to for health. Guidance were never taught how food affects these conditions and what drug has come to the rescue Glp. One S. Ozempic wegovy. They’re great for weight loss. They’re great for treating diabetes. But why are they here? Well, these numbers are. Why, they’re here. This is staggering to put 352,000 Americans under the age of 20 on a glp, one that they’re going to be on for the rest of their lives at a minimum of $1,200 per month. All we have to do is do the math, you guys, and we can see exactly what’s happening to our country, and who is getting rich, and who is getting the short end of the stick. You’ve become a moneymaker to the pharmaceutical industry because nobody has taught you how to eat properly, how to live, how to have a healthy lifestyle, and how to prevent disease, or how to actually reverse type 2 diabetes, because it’s reversible in many cases, especially young people. And we do none of that. All we do is prescribe medications. Metformin. Glp, one for the rest of your life from 20 years old to 75, or 80, you’re going to be taking medications that are making the pharmaceutical companies more wealth and creating a disease on top of a disease on top of a disease. These deficiencies in nutritional education happen at all levels of medical training, and there’s been little improvement, despite decades of calls for reform. In 1985, the National Academy of Sciences report that they recommended at least 25 h of nutritional education in medical school. But a 2015 study showed only 29% of medical schools met this goal, and a 2023 study suggests the problem has become even worse. Only 7.8% of medical students reported 20 or more hours of nutritional education across all 4 years of medical school. This systemic lack of nutrition, nutritional education has been attributed to several factors a dearth of qualified instructors for nutritional courses, since most physicians do not understand nutrition well enough to teach it competition for curriculum time, with schools focusing on pharmaceutical interventions rather than lifestyle medicine and a lack of external incentives that support schools, teaching nutrition. And ironically, many medical schools are part of universities that have nutrition departments with Phd. Trained professors who could fill this gap by teaching nutrition in medical schools but those classes are often taught by physicians who may not have adequate nutritional training themselves. This explains so much about what I see in my practice. Patients come to me confused and frustrated because their primary care doctors can’t answer basic questions about how food affects their health conditions. And these doctors aren’t incompetent. They simply were never taught this information. And the result is that these physicians graduate, knowing how to prescribe medications for diabetes, but not how dietary changes can prevent or reverse it. They can treat high blood pressure with pharmaceuticals, but they may not know that specific nutritional approaches can be equally or more effective. This isn’t the doctor’s fault. It’s the predictable result of medical education systems that was deliberately designed to focus on patentable treatments rather than natural healing approaches. And remember this traces back to the Rockefeller influence on medical education. You can’t patent an apple or a vegetable. But you can patent a drug now. Why can’t we trust most medical studies? Well this just gets even better. I need to address something that’s crucial for you to understand as you navigate health information. Why so much of the medical research you hear about in the news is biased, and why peer Review isn’t the gold standard of truth you’ve been told it is. The corruption in medical research by pharmaceutical companies is not a conspiracy theory. It’s well documented scientific fact, according to research, published in frontiers, in research, metrics and analytics. When pharmaceutical and other companies sponsor research, there is a bias. A systematic tendency towards results serving their interests. But the bias is not seen in the formal factors routinely associated with low quality science. A Cochrane Review analyzed 75 studies of the association between industry, funding, and trial results, and these authors concluded that trials funded by a drug or device company were more likely to have positive conclusions and statistically significant results, and that this association could not be explained by differences in risk of bias between industry and non-industry funded trials. So think about that. According to the Cochrane collaboration, industry funding itself should be considered a standard risk of bias, a factor in clinical trials. Studies published in science and engineering ethics show that industry supported research is much more likely to yield positive outcomes than research with any other sponsorship. And here’s how the bias gets introduced through choice of compartor agents, multiple publications of positive trials and non-publication of negative trials reinterpreting data submitted to regulatory agencies, discordance between results and conclusions, conflict of interest leading to more positive conclusions, ghostwriting and the use of seating trials. Research, published in the American Journal of Medicine. Found that a result favorable to drug study was reported by all industry, supported studies compared with two-thirds of studies, not industry, supported all industry, supported studies showed favorable results. That’s not science that’s marketing, masquerading as research. And according to research, published in sciencedirect the peer review system which we’re told ensures quality. Science has a major limitation. It has proved to be unable to deal with conflicts of interest, especially in big science contexts where prestigious scientists may have similar biases and conflicts of interest are widely shared among peer reviewers. Even government funded research can have conflicts of interest. Research published in pubmed States that there are significant benefits to authors and investigators in participating in government funded research and to journals in publishing it, which creates potentially biased information that are rarely acknowledged. And, according to research, published in frontiers in research, metrics, and analytics, the pharmaceutical industry has essentially co-opted medical knowledge systems for their particular interests. Using its very substantial resources. Pharmaceutical companies take their own research and smoothly integrate it into medical science. Taking advantage of the legitimacy of medical institutions. And this corruption means that much of what passes for medical science is actually influenced by commercial interests rather than pursuant of truth. Research published in Pmc. Shows that industry funding affects the results of clinical trials in predictable directions, serving the interests of the funders rather than the patients. So where can we get this reliable, unbiased Health information, because this is critically important, because your health decisions should be based on the best available evidence, not marketing disguised as science. And so here are some sources that I recommend for trustworthy health and nutritional information. They’re independent academic sources. According to Harvard Chan School of public health their nutritional, sourced, implicitly states their content is free from industry, influence, or support. The Linus Pauling Institute, Micronutrient Information Center at Oregon State University, which, according to the Glendale Community college Research Guide provides scientifically accurate information about vitamins, minerals, and other dietary factors. This Institute has been around for decades. I’ve used it a lot. I’ve gotten a lot of great information from them. Very, very trustworthy. According to the Glendale Community College of Nutrition Resource guide Tufts, University of Human Nutritional Research Center on aging is one of 6 human nutrition research centers supported by the United States Department of Agriculture, the Usda. Their peer reviewed journals with strong editorial independence though you must still check funding resources. And how do you evaluate this information? Online? Well, according to medlineplus and various health literacy guides when evaluating health information medical schools and large professional or nonprofit organizations are generally reliable sources, but remember, it is tainted by the Rockefeller method. So, for example, the American College of cardiology. Excuse me. Professional organization and the American Heart Institute a nonprofit are both reliable sources. Sorry about that of information on heart health and watch out for ads designed to look like neutral health information. If the site is funded by ads they should be clearly marked as advertisements. Excuse me, I guess I’m talking just a little too much now. So when the fear of medicine becomes deadly. Now, I want to address something critically important that often gets lost in conversations about health, sovereignty, and questioning the medical establishment. And while I’ve spent most of this episode explaining how the Rockefeller medical system has created dependency and suppressed natural healing wisdom. There’s a dangerous pendulum swing happening that I see in my practice. People becoming so fearful of pharmaceutical interventions that they refuse lifesaving treatments when they’re genuinely needed. This is where balance and clinical judgment become absolutely essential. Yes, we need to reclaim our basic health literacy and reduce our dependency on unnecessary medical interventions. But there are serious bacterial infections that require immediate antibiotic treatment, and the consequences of avoiding treatment can be devastating or even fatal. So let me share some examples from research that illustrate when antibiotic fear becomes dangerous. Let’s talk about Lyme disease, and when natural approaches might not be enough. The International Lyme Disease Association ilads has conducted extensive research on chronic lyme disease, and their findings are sobering. Ileds defines chronic lyme disease as a multi-system illness that results from an active and ongoing infection of pathogenic members of the Borrelia Brdorferi complex. And, according to ilads research published in their treatment guidelines, the consequences of untreated persistent lyme infection far outweigh the potential consequences of long-term antibiotic therapy in well-designed trials of antibiotic retreatment in patients with severe fatigue, 64% in the treatment arm obtained clinically significant and sustained benefit from additional antibiotic therapy. Ilas emphasizes that cases of chronic borrelia require individualized treatment plans, and when necessary antibiotic therapy should be extended their research demonstrates that 20 days of prophylactic antibiotic treatment may be highly effective for preventing the onset of lyme disease. After known tick bites and patients with early Lyme disease may be best served by receiving 4 to 6 weeks of antibiotic therapy. Research published in Pmc. Shows that patients with untreated infections may go on to develop chronic, debilitating, multisystem illnesses that is difficult to manage, and numerous studies have documented persistent Borrelia, burgdorferi infection in patients with persistent symptoms of neurological lyme disease following short course. Antibiotic treatment and animal models have demonstrated that short course. Antibiotic therapy may fail to eradicate lyme spirochetes short course is a 1 day. One pill treatment of doxycycline. Or less than 20 days of antibiotics, is considered a short course. It’s not long enough to kill the bacteria. The bacteria’s life cycle is about 21 days, so if you don’t treat the infection long enough, the likelihood of that infection returning is significant. They’ve also done studies in the petri dish, where they show doxycycline being put into a petri dish with active lyme and doxycycline does not kill the infection, it just slows the replication of it. Therefore, using only doxycycline, which is common practice in lyme disease may not completely eradicate that infection for you. So let’s talk about another life threatening emergency. C. Diff clostridia difficile infection, which represents another example where antibiotic treatment is absolutely essential, despite the fact that C diff itself is often triggered by antibiotic use. According to Cleveland clinic C. Diff is estimated to cause almost half a million infections in the United States each year, with 500,000 infections, causing 15,000 deaths each year. Studies reported by Pmc. Found thirty-day Cdi. Mortality rates ranging from 6 to 11% and hospitalized Cdi patients have significantly increased the risk of mortality and complications. Research published in Pmc shows that 16.5% of Cdi patients experience sepsis and that this increases with reoccurrences 27.3% of patients with their 1st reoccurrence experience sepsis. While 33.1% with 2 reoccurrences and 43.2% with 3 or more reoccurrences. Mortality associated with sepsis is very high within hospital 30 days and 12 month mortality rates of 24%, 30% and 58% respectively. According to the Cdc treatment for C diff infection usually involves taking a specific antibiotic, such as vancomycin for at least 10 days, and while this seems counterintuitive, treating an antibiotic associated infection with more antibiotics. It’s often lifesaving. Now let’s talk about preventing devastating complications. Strep throat infections. Provide perhaps the clearest example of when antibiotic treatment prevents serious long-term consequences, and, according to Mayo clinic, if untreated strep throat can cause complications such as kidney inflammation and rheumatic fever. Rheumatic fever can lead to painful and inflamed joints, and a specific type of rash of heart valve damage. We also know that strep can cause pans pandas, which is a systemic infection, often causing problems with severe Ocd. And anxiety and affecting mostly young people. The research is unambiguous. According to the Cleveland clinic. Rheumatic fever is a rare complication of untreated strep, throat, or scarlet fever that most commonly affects children and teens, and in severe cases it can lead to serious health problems that can affect your child’s heart. Joints and organs. And research also shows that the rate of development of rheumatic fever in individuals with untreated strep infections is estimated to be 3%. The incidence of reoccurrence with a subsequent untreated infection is substantially greater. About 50% the rate of development is far lower in individuals who have received antibiotic treatment. And according to the World health organization, rheumatic heart disease results from the inflammation and scarring of the heart valves caused by rheumatic fever, and if rheumatic fever is not treated promptly, rheumatic heart disease may occur, and rheumatic heart disease weakens the valves between the chambers of the heart, and severe rheumatic heart disease can require heart surgery and result in death. The who states that rheumatic heart disease remains the leading cause of maternal cardiac complications during pregnancy. And additionally, according to the National Kidney foundation. After your child has either had throat or skin strep infection, they can develop post strep glomerial nephritis. The Strep bacteria travels to the kidneys and makes the filtering units of the kidneys inflamed, causing the kidneys to be able to unable or less able to fill and filter urine. This can develop one to 2 weeks after an untreated throat infection, or 3 to 4 weeks after an untreated skin infection. We need to find balance. And here’s what I want you to understand. Questioning the medical establishment and developing health literacy doesn’t mean rejecting all medical interventions. It means developing the wisdom to know when they’re necessary and lifesaving versus when they’re unnecessary and potentially harmful. When I see patients with confirmed lyme disease, serious strep infections or life. Threatening conditions like C diff. I don’t hesitate to recommend appropriate therapy but I also work to support their overall health address, root causes, protect and restore their gut microbiome and help them recover their natural resilience. The goal isn’t to avoid all medical interventions. It’s to use them wisely when truly needed, while simultaneously supporting your body’s inherent healing capacity and addressing the lifestyle factors that created the vulnerability. In the 1st place. All of this can be extremely overwhelming, and it can be frightening to understand or learn. But remember, the power that you have is knowledge. The more you learn about what’s actually happening in your health, in understanding nutrition. in learning what your body wants to be fed, and how it feels, and working with practitioners who are holistic in nature, natural, integrative, functional, whatever we want to call that these days. The more you can learn from them, the more control you have over your own health and what I would urge you to do is to teach your children what you’re learning. Teach them how to live a healthy lifestyle, teach them how to keep a clean environment. This is how we take back our own health. So thank you for joining me today on, let’s talk wellness. Now, if this episode resonated with you. Please share it with someone who could benefit from understanding how the Rockefeller medical system has shaped our approach to health, and how to reclaim your body’s wisdom while using medical care appropriately when truly needed. Remember, wellness isn’t just about feeling good. It’s about understanding your body, trusting its wisdom, supporting its natural healing capacity, and knowing when to seek appropriate medical intervention. If you’re ready to explore how functional medicine can help you develop this deeper health knowledge while addressing root causes rather than just managing symptoms. You can get more information from serenityhealthcarecenter.com, or reach out directly to us through our social media channels until next time. I’m Dr. Dab, reminding you that your body is your wisest teacher. Learn to listen, trust the process, use medical care wisely when needed, and take care of your body, mind, and spirit. Be well, and we’ll see you on the next episode.The post Episode 250 -The Great Medical Deception first appeared on Let's Talk Wellness Now.

If you've got a penicillin allergy, this episode is crucial for you! That's because you can outgrow a drug allergy like this even if you developed it as an adult. Antibiotic allergies are either misdiagnosed or fade over time. Even if you avoid taking antibiotics like the plague, having a drug allergy on your medical chart can end up limiting treatment options if you find yourself truly needing them.In this episode, my guest, Dr. Mariana Castells, breaks down how drug allergies are diagnosed, how long they take to disappear, why they can appear later in life, and how “drug delabeling” could dramatically improve your care (especially when something serious happens). Dr. Mariana Castells, M.D., Ph.D., is a world-renowned expert in allergy and immunology with over 30 years of experience. Whether you have an antibiotic allergy (or you know someone who does), this is a must-listen interview!⭐️Mentioned in This Episode:- See all the references

Today, synthetic bacteriophages, a breakthrough vaccine for TB, and how unpicking the pathways used to make antibiotics are helping scientists to combat rising rates of antimicrobial resistance around the world... Like this podcast? Please help us by supporting the Naked Scientists

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