Podcasts about Prognosis

Dr. Kelly Makielski and Dr. Jaime Modiano from the University of Minnesota join us on OsteoBites to discuss comparative extracellular vesicle (EV) biomarkers for osteosarcoma risk and prognosis.They are investigating extracellular vesicle (EV) transcriptomic profiles as minimally invasive biomarkers in canine and pediatric osteosarcoma in two ongoing studies. In the Canine Osteosarcoma Early Detection (COED) study, they are sequencing EV RNA from otherwise healthy dogs in breeds at elevated risk of osteosarcoma to identify gene signatures for the early detection and risk assessment of osteosarcoma. In parallel, they are conducting the KIDsCAN study, where we are sequencing EVs from pediatric osteosarcoma patients to identify prognostic signatures that could ultimately guide treatment intensity, aiming to minimize long-term therapy-associated morbidity without negatively impacting survival. Preliminary results from COED will be shared, along with how their comparative approach is helping to guide the KIDsCAN study.Kelly M. Makielski, DVM, DACVIM (SAIM) is an Assistant Professor of Small Animal Internal Medicine at the University of Minnesota College of Veterinary Medicine and Masonic Cancer Center. Her research focuses on extracellular vesicle (EV) biology and comparative oncology, using naturally occurring cancers in dogs to inform human cancer biology and treatment. She is the recipient of an NIH K01 investigating EV–based biomarkers for osteosarcoma prognosis in pediatric osteosarcoma, to guide personalized therapy and reduce treatment-related morbidity.Dr. Jaime Modiano holds the Alvin and June Perlman Endowed Chair of Animal Oncology and is director of the Animal Cancer Care and Research Program of the College of Veterinary Medicine and the Masonic Cancer Center, University of Minnesota. He completed his training through the Veterinary Medical Scientist Training Program (VMD, PhD) at the University of Pennsylvania, and he followed it with a residency in Clinical Pathology at Colorado State University and a post-doctoral fellowship at the National Jewish Center for Immunology and Respiratory Medicine. Before joining the University of Minnesota, he served on the faculties of Texas A&M University and the University of Colorado Health Sciences Center. Dr. Modiano has also worked in the private sector, as founder of several start-up companies, and as Director of Cancer Immunology and Immunotherapy for the Donald Monk Cancer Research Foundation. Through his research, Dr. Modiano seeks to understand how and why cancer happens and to develop strategies for improving the health and well-being of companion animals and humans alike.

Guest: David Feller-Kopman, MD Cytology via thoracentesis remains the first-line approach for diagnosing malignant pleural effusion (MPE), yet its sensitivity is limited. leaving many patients undiagnosed or delayed in treatment. In this expert-led discussion, Dr. David Feller-Kopman explores the limitations of current diagnostic methods and the evolving role of biomarkers in enhancing both diagnostic accuracy and prognostic insight. Dr. Feller-Kopman is a Professor of Medicine at the Geisel School of Medicine at Dartmouth and the Chief of Pulmonary and Critical Care Medicine at Dartmouth-Hitchcock Medical Center, and he discussed this topic at the 2025 CHEST Annual Meeting.

Navigating Autism and End of Life: A Conversation with Dr. Caroline EltonIn this episode of The Girl Doc Survival Guide, host Christine invites back psychologist Dr. Caroline Elton, who has extensive experience supporting doctors' emotional wellbeing. Dr. Elton discusses her new book, Looking After: A Portrait of My Autistic Brother, and touches on end-of-life care.00:00 Introduction and Guest Welcome00:59 Discussing 'Looking After: Portrait of My Autistic Brother'01:22 Lionel's Early Life and Autism Diagnosis02:51 Mother Blaming and Historical Context05:09 Lionel's Leukemia Diagnosis and End of Life Care05:57 Challenges of Communicating About Death11:42 Autism Hospital Passport and Caregiving13:03 Reflections on Lionel's Life and Impact16:42 Final Thoughts on End of Life Care for Autistic Individuals

YDDDY InstagramShortya_official We set up at the Abilities Expo Chicago and sat down with Abad, a 23-year-old Chicagoan seeing the convention for the first time, to talk grit, gear, and the joy of sports. Doctors once said he wouldn't walk or talk; today he's walking short distances with braces, rolling long ones with a chair, making sports content, and using a backyard hoop as a meditation mat. It's a Speedcast with heart: the kind of conversation that jumps from all-terrain wheelchairs and grant options to Cubs optimism and the calm that only a clean jumper can bring.We dig into what sacral agenesis actually means day to day—how a missing tailbone touches movement, balance, and even the most basic routines—and why a broken power chair is more than an inconvenience. Abad opens up about playing wheelchair basketball and softball before the pandemic cut seasons short, then finding a rhythm again at home. He shares how posting sports takes on TikTok builds a community that understands both the box score and the backstory.There's purpose threaded through the plays. Abad's message is direct: your disability doesn't define you. He channels that belief into action with his brand YDDDY, directing proceeds to Free Wheelchair Mission to expand access to mobility worldwide. We swap notes on adaptive tech that widens the map—chairs built for sand, setups that reduce fatigue, smarter paths to funding—and celebrate the small routines that protect mental health. If you're into adaptive sports, disability advocacy, mobility tech, or just a great Chicago sports chat, you'll feel at home here.

Barry emphasized the importance of finishing the year strong while laying the groundwork for 2026, comparing it to a sprinter running through the finish line. He introduced five key pillars for success—mindset and resilience, productivity, financial resources, relationships, and vision—and encouraged attendees to self-assess their strengths and gaps. Barry shared strategies like journaling, affirmations, and meditation to build resilience, along with shifting from time management to activity management to maximize productivity. He also highlighted the role of AI and virtual assistants in saving time, reframing expenses as business investments, and being intentional about building supportive networks. Barry urged participants to set a 12-month vision now rather than waiting for January, stressing that clarity of purpose and consistent small improvements (Kaizen) drive growth. He closed by inviting attendees to upcoming events and training, reinforcing that momentum, mindset, and vision are the foundation for long-term success.

Analysts Don Kellogg and Daryl Schoolar discuss the recent ZTE Global Summit & User Congress, including insights on the practical use of AI, 6G development, and global network standardization.00:00 Episode intro 00:27 ZTE event overview 01:40 Current and future AI network applications 05:44 How much AI is too much? 06:13 The state of the international market 07:56 Operators need the “next big thing” 09:01 ZTE's Pre6G prototype and 6G development 11:38 Prognosis for global network standardization 13:37 Episode wrap-upTags: telecom, telecommunications, wireless, prepaid, postpaid, cellular phone, Don Kellogg, Daryl Schoolar, ZTE, AI, network, automation, LLMs, microloans, gaming, video, China, 5G, slicing, private networks, B2B, 6G, hardware

  Summary In this conversation, Amas Tenumah and Bob Furniss discuss the evolution of contact centers, the impact of CRM systems like Salesforce, and the role of AI in enhancing agent performance. They reflect on the historical context of CRM, the challenges faced by agents, and the future of customer service technology, particularly focusing on the Agent Force initiative. The discussion also touches on the sentiment within the Salesforce community and the potential for new competitors in the market.   Takeaways Salesforce has become a dominant player in the CRM space. The evolution of contact centers has been significant over the years. AI can enhance agent performance rather than replace them. Understanding customer needs is crucial for effective service. The Agent Force initiative aims to improve agent capabilities. There is a negative sentiment towards Salesforce in the contact center community. The cost of building technology is decreasing, making competition more feasible. AI's role in customer service is still evolving and needs to focus on agents. Salesforce must communicate its value to agents to maintain loyalty. The future of customer service technology is uncertain but full of potential. Chapters 00:00 Introduction and Context Setting 01:29 The Evolution of CRM and Contact Centers 06:05 Current Trends in Salesforce and AI 11:13 Agent Force and the Future of Customer Service 15:54 Prognosis for Salesforce and the Industry

In this episode of Derms and Conditions, host James Q. Del Rosso, DO, is joined by Natasha Mesinkovska, MD, associate professor of Dermatology at UC Irvine, to discuss the multifaceted challenges of alopecia areata (AA), an autoimmune condition with complex comorbidities and broad psychosocial implications. The conversation begins with the stigma of hair loss and the importance of addressing the patient's emotional well-being. Dr Mesinkovska highlights her approach: asking simple but direct questions about how patients are coping and connecting them with mental health resources when needed. Comorbidities and workup are also addressed, with Dr Mesinkovska sharing her pragmatic approach to labs: thyroid-stimulating hormone test as a baseline, selective additional testing for patients with indicators of comorbidities, and requesting consultation with endocrinology when indicated. Prognosis is also discussed, with childhood onset and family history noted as adverse factors. They next explore treatment expectations, beginning with the typical timeline of response seen with oral JAK inhibitors and the importance of allowing several months for optimal hair regrowth. Many patients, once regrowth occurs, ask when they can stop therapy in hopes that results will persist without ongoing treatment; this is an important moment to counsel patients on the chronic nature of AA and emphasize that discontinuing therapy often leads to renewed hair loss. Continuing oral JAK inhibitor therapy offers the greatest likelihood of maintaining regrowth over time.  They review clinical data on the durability of response of the JAK inhibitors for AA, which has shown that relapse of hair loss is common once treatment is discontinued. For those who elect to stop therapy, it is essential to emphasize the need to resume treatment promptly at the first signs of relapse, under supervision of their dermatologist. Ongoing clinical and laboratory monitoring is also highlighted as critical to ensure long-term safety. Dr Mesinkovska then discusses differential diagnoses for AA, covering lichen planopilaris, trichotillomania, and other mimickers, with biopsy reserved for challenging cases. She next reviews the 3 approved JAK inhibitors for AA, baricitinib, ritlecitinib, and deuruxolitinib, highlighting differences in efficacy, dosing, speed of response, and the role of CYP2C9 testing specific to deuruxolitinib. Clinical study data are used to outline the features that distinguish deuruxolitinib, the newest oral JAK inhibitor, from the other agents. These include a potentially faster onset of hair regrowth, enhanced efficacy with twice-daily dosing, and the ability to identify individuals who metabolize the drug more slowly through CYP2C9 testing. Tune in to the full episode to hear how dermatologists can assess comorbidities, select systemic therapies, manage patient expectations, and support the psychosocial needs of those with AA to achieve more comprehensive care.

              “Focus Bend” (Original Mix) - Cendryma. (UV).              “Second City” (Forty Cats Remix) - Belms, Ritchie Haydn. (3rd Avenue).              “Ceaseless Metamorphosis” (Extended Mix) - Drekkan. (Univack).              “Neurovoid” (Original Mix) - Venao, Mind Echoes. (Deep Down Music).              “Many Things” (ELECGROUND Extended Remix) - Teleport-X, XAVI st. (XAVI st, Teleport-X).              “Syntergy” (Original Mix) - Stan Kolev. (Outta Limits).              “Sister's Mantra” (Paul Thomas Remix) - Sistersweet. (RKP).              “Path Home” (Extended Mix) - Faero, Coqueit. (Univack).              “Twenty Miami's Ago” (Cendryma Extended Mix) - Blake Jarrell. (UV).              “Messier 28 (Original Mix) - Analog Jungs. (Constellation).              “Infinity” (Extended Mix) - Colin Rouge, Komissa. (Clubmasters Records).              “Elounda” (Original Mix) - ChristianJ. (Prognosis).              “Time Slip” (Original Mix) - Cloaked. (Higher States).              “Activator” (Original Mix) - Supacooks, Bondarev. (WARPP).              “Desired State” (Original Mix) - Stan Kolev. (Outta Limits).              “Echosphere” (Extended Mix) - Solis (AR). (Univack).              “The Dream Of Watts” (Original Mix) - Adrien (AR). (One Kind Of Music).              “Bender” (Ruls Remix) - Andres Moris. (Undergroove Music).              “Keep The Love Alive” (Instrumental Mix) - Arthur Baker, Ali Love. (New State Music).              “Alone In The Dark” (Kyotto Remix) - Gai Barone, Cary Crank. (Sunexplosion).

Dr. Monty Pal and Dr. Matteo Lambertini discuss a compelling global study on the clinical behavior of breast cancer in young BRCA1 and BRCA2 carriers, the association of pre-diagnostic awareness of BRCA status with prognosis, and the importance of identifying healthy people who are at risk of carrying the BRCA1/2 pathogenic variants. TRANSCRIPT Dr. Monty Pal: Well, hello everyone, and welcome to the ASCO Daily News Podcast. I'm your host, Dr. Monty Pal. I'm a medical oncologist, professor, and vice chair of medical oncology at the City of Hope Comprehensive Cancer Center in Los Angeles. Now, when we think about genetic testing, whether for patients diagnosed with breast cancer or for other family members of them, it seems to be widely underutilized. Today, we're going to be discussing a recently published study in the Journal of Clinical Oncology that reported on the clinical behavior of breast cancer and specifically young BRCA1 and BRCA2 carriers, and the association of pre-diagnostic awareness of BRCA status with prognosis. I thought this was just a fascinating piece, and I honestly couldn't wait to have this conversation. It's a really compelling paper that highlights the importance of identifying healthy people who are at risk of carrying the BRCA1/2 pathogenic variants, and really the need for genetic counseling and testing to inform people about early detection that could lead to a better prognosis. I'm really delighted to welcome the study's lead author, Dr. Matteo Lambertini. He really needs no introduction. He's very well known in the breast cancer world for his amazing contributions to fertility in the context of breast cancer, to pregnancy in the context of breast cancer, and genetic testing. He's an associate professor at the University of Genova, and a breast cancer medical oncologist at the San Martino Polyclinic Hospital in Genova, Italy.  Dr. Lambertini, thank you so much for joining us today. Dr. Matteo Lambertini: Thank you very much, Dr. Pal. It's a great pleasure. Dr. Monty Pal: Oh, thanks. And just FYI, if you're listening in and you want to hear our disclosures, they're all listed at the transcript of this podcast.  So, I poured through this paper [Clinical Behavior of Breast Cancer in Young BRCA Carriers and Prediagnostic Awareness of Germline BRCA Status] yesterday, Dr. Lambertini, and first of all, congratulations on this study. This was a huge international multicenter effort, 4,752 patients. How did you pool all these patients with young breast cancer? Dr. Matteo Lambertini: Thanks a lot for the question. Yes, this was an effort made by several centers all over the world. The main idea behind the creation of this network that we have named as BRCA BCY Collaboration, was to get as many data as possible in a sort of niche patient population in the breast cancer field, meaning women diagnosed with breast cancer at the age of 40 years or younger, and all of them being BRCA carriers. We know that around, in the Western world, around 5% of breast cancer cases are being diagnosed under the age of 40 years, and among them around 10-15% are BRCA carriers. So, I would say it's a relatively rare patient population where we did not have a lot of evidence to support our choices in terms of counseling on treatment, prevention, and oncofertility as well. That was the idea behind the creation of this network that includes many centers. Dr. Monty Pal: Yeah. You know, what's so interesting about this is that you sort of draw this line between patients who have BRCA testing at the time of diagnosis and then BRCA testing earlier in their course and then leading to a diagnosis perhaps. And I think that's where really sort of the dichotomy in outcome sits. Can you maybe elaborate on this and tell us about timing of genetic testing in this study and what that meant ultimately in terms of prognosis? Dr. Matteo Lambertini: In this specific analysis from this large network, including almost 5,000 women with breast cancer diagnosed at the age of 40 years or younger and being a BRCA carrier, we looked specifically into the timing of genetic testing because this is a retrospective study and the criteria for inclusion are those that I have just mentioned, so diagnosis at a young age plus carrying germline BRCA pathogenic or likely pathogenic variant. In this analysis, we have looked into the time the patient has got the genetic testing and particular we focused on two populations: those that were diagnosed, knowing already to be a BRCA carrier, and those that got tested after being diagnosed with breast cancer. And the main findings from this analysis have been that knowing to be a BRCA carrier was associated with a lower stage at the time of diagnosis, meaning more T1 tumors, so a tumor less than 2 cm, more node-negative disease, and this translated into less aggressive treatment, so less often axillary dissection, less often use of chemotherapy and anthracycline-based chemotherapy. And even more importantly, we have seen a better overall survival for those patients that were diagnosed already knowing to be BRCA carriers as compared to those tested after breast cancer diagnosis. These results after adjusting for all the confounding, stage, treatment and so on, there was not significant anymore, meaning that it's not the timing of test per se that is probably leading to a better survival, but it is the fact that knowing to be a BRCA carrier would likely translate into having access to all the preventive measures that we have in this setting and this will translate into an overall survival benefit, so in terms of saving more lives in young BRCA carriers. Dr. Monty Pal: I think it's such an important point, and it's one that I think might sound implicit, right, but it needs to be proven, I think, through a study like this. You know, the fact that finding this early, identifying the mutation, doing enhanced screening, and so forth, is really going to lead to superior clinical outcomes. One of the things that I think many people puzzle over, including myself, is what to do? I personally occasionally will see BRCA altered patients in the context of prostate cancer. But that's a very different population of individuals, right? Typically older men. In young females with BRCA mutation, I guess there's a specific set of considerations around reproductive health. You'd already highlighted preventive strategies, but what sorts of things should we be talking about in the clinics once a patient's diagnosed and once perhaps their breast cancer diagnosis is established? Dr. Matteo Lambertini: Yes, exactly. Knowing to be a BRCA carrier has a lot of implications from prevention to treatment to survivorship issues including reproductive counseling. And this is important not only for the patient that has been diagnosed with breast cancer but also for all the family members that will get tested and maybe identify with this sort of genetic alteration before diagnosis of cancer. Why this is important is because we have access to very effective preventive measures, a few examples: MRI screening, which starts at a very young age and normally young women don't have an effective screening strategy outside the BRCA field. Also, primary preventive measures, for example, risk-reducing surgery. These women are known to have a high risk of breast cancer and high risk of ovarian cancer. So the guidelines are suggesting to undergo risk-reducing salpingo-oophorectomy at a young age, so 35 to 40 years in BRCA1 carrier, 40 to 45 years in BRCA2 carrier. And also risk-reducing mastectomy should be discussed because it is a very effective way to prevent the occurrence of breast cancer. And in some situations, including the setting that we are talking about, so young women with breast cancer, BRCA carrier, also risk-reducing mastectomy has shown to improve overall survival.  On the other side, once diagnosed with breast cancer, nowadays knowing to be or not a BRCA carrier can make a difference in terms of treatment. We have PARP inhibitors in the early setting, in the adjuvant setting as well as in the metastatic setting. And in terms of survivorship implication, one of the critical aspects for young women is the oncofertility care which is even more complicated when we talk about BRCA carriers that are women candidates for gynecological surgery at a very young age. So this sort of counseling is even more complicated. Dr. Monty Pal: One of the other things, and this is subtle in your paper and I hope you don't mind me bringing it up, is the difference between BRCA1 and BRCA2. It really got me thinking about that because there are differences in phenotype and manifestation. Do you mind just expanding on that a little bit for the audience because I think that's a really important reminder that you brought up in the discussion? Dr. Matteo Lambertini: The difference between BRCA1 and BRCA2 carriers has been known that there are different phenotypes of breast cancer that are more often diagnosed in these two different populations. Normally BRCA1 carriers have a higher likelihood to develop a triple negative breast cancer as compared to BRCA2 carriers, more likely to develop a hormone receptor-positive HER2-negative disease. In this study, again, a specific population of young women with breast cancer, we have seen the same findings, mostly triple negative disease in BRCA1 carrier, mostly luminal-like disease in BRCA2 carrier. But what's novel or interesting from this study is to look also at the age at the time of diagnosis of this disease. And particularly in BRCA1 carriers, we should be sort of more careful about diagnosis of breast cancer and also other primary tumors including ovarian cancer because the risk of developing these malignancies is higher even at a younger age as compared to BRCA2 carriers. And this has implications also in the primary and secondary prevention that we were talking about earlier. Dr. Monty Pal: Oh, interesting. I guess the fundamental question then from your paper becomes, how do we get at the right patients for screening for BRCA1 and BRCA2? And I realize our audience here is largely oncologists who are going to be listening to this podcast, oncology providers, MDs, nurses, etc. But maybe speak for a moment to the general practitioner. Are there things that, for instance, a general practitioner should be looking for to say, “Wait a minute, this patient's high risk, we should consider BRCA1, BRCA2 testing or germline screening”? Dr. Matteo Lambertini: Yes, it's a very important question for the breast cancer community. After the updated ASCO guideline, the counseling is way easier because right now the age cutoff goes up to 65 years, meaning that all the patients diagnosed with breast cancer below the age of 65 years should be tested these days. And then above the age of 65, there are different criteria like triple-negative disease or family history. From a general practitioner standpoint, it's of course a bit more difficult, but knowing particularly the family history of the person that they have in front will be crucial to know if there are cases of breast cancer diagnosed at a young age, maybe triple-negative cases, knowing cases of ovarian cancer in first-degree relatives or pancreatic cancer in first-degree relatives, and of course cases of prostate cancer as well. So, I would say probably mostly the family side will be important from a general practitioner perspective.  From an oncology one, the other point that I think is important to stress also based on the data that we have shown in this publication is that having a case of breast cancer known to carry a BRCA pathogenic or likely pathogenic variant. It means that all the people around this case should get tested and if found to be BRCA carrier and healthy carrier, these people should also undergo the primary and secondary prevention strategies because this is very critical also to improve their outcomes and try to avoid the developing of breast or ovarian cancer, but also in the case of diagnosis of this disease, a diagnosis at an earlier stage, as we have seen in this paper. Dr. Monty Pal: Brilliant. I'm going to diverge from our list of questions here and close by asking a question that I have at the top of my mind. You're very young. I know our podcast listeners can't see you, but you're very, very young. Dr. Matteo Lambertini: Thank you. Thank you for that. Not so young but yeah. Dr. Monty Pal: You have nearly 300 papers. Your H-index is 67. You've already made these seminal contributions, as I outlined it from the outset, regarding fertility, regarding use of GnRH analogs, regarding pregnancy and breast cancer. What are you studying now? What are you really excited about right now that you're doing that you think might potentially be practice changing? Give us a little teaser. Dr. Matteo Lambertini: Yeah. Thanks a lot, Dr. Pal. Receiving this compliment from you is fantastic. So, thanks a lot for that. From my side, in terms of my research, I've been interested in the field of breast cancer in young women since the start of my training. I've had very good mentors from Italy, from Europe, from the U.S. I'm still interested in this field, so I think we still have a lot to learn to try to improve the care of young women with breast cancer. For example, the oncofertility care, which is something I worked a lot over the past years. Now with all the new treatment options, there's a sort of new chapter of oncofertility counseling. So, what's the impact of immunotherapy? What's the impact of the new targeted agents?  More on the genetic aspects, now we know that there's not only BRCA1 or BRCA2. There are a lot of other different genes that may increase the risk of breast cancer and other malignancies. And also for these genes, we really don't have a lot of evidence to counsel women on prognosis, treatment, prevention strategy. So we need to learn way more for this special patient population that are quite rare, and so we really need a multicenter academic effort to try to give some evidence in this field. Dr. Monty Pal: Yeah. It's tough because these are rare circumstances, but, you know, I think that you've done really well to sort of define some collective experiences that I think really define therapy. I mean, I just remember when I was in training 25 years ago, just reading through textbooks where all the experience around breast cancer and pregnancy was really just very sort of anecdotal almost, you know? And so it's great to see that the state of the science has moved forward.  Well, gosh, I really enjoyed our conversation today. I think your study really reminds us how powerful genetic information is in terms of improving outcomes. And, you know, hopefully this will lead some individuals to perhaps test more broadly in appropriate settings. So, thank you so much, Matteo, for joining us today with your fantastic insights on the ASCO Daily News Podcast. Dr. Matteo Lambertini: Thank you very much, Dr. Pal. It's a real pleasure. Dr. Monty Pal: And thanks to our listeners too. You'll find a link to Dr. Lambertini's study in the transcript of this episode. Finally, if you value the insights that you heard today on the ASCO Daily News Podcast, please rate, review, and subscribe wherever you get your podcasts. Thanks a ton. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Find out more about today's speakers:    Dr. Sumanta (Monty) Pal  @montypal  Dr. Matteo Lambertini @matteolambe   Follow ASCO on social media:     @ASCO on Twitter    ASCO on Bluesky   ASCO on Facebook     ASCO on LinkedIn     Disclosures:    Dr. Monty Pal:   Speakers' Bureau: MJH Life Sciences, IntrisiQ, Peerview  Research Funding (Inst.): Exelixis, Merck, Osel, Genentech, Crispr Therapeutics, Adicet Bio, ArsenalBio, Xencor, Miyarsian Pharmaceutical  Travel, Accommodations, Expenses: Crispr Therapeutics, Ipsen, Exelixis  Dr. Matteo Lambertini: Consulting or Advisory Role: Roche, Novartis, Lilly, AstraZeneca, Pfizer, MSD, Exact Sciences, Gilead Sciences, Seagen, Menarini, Nordic Pharma Speakers' Bureau: Takeda, Roche, Lilly, Novartis, Pfizer, Sandoz, Ipsen, Knight Therapeutics, Libbs, Daiichi Sankyo, Gilead Sciences, AstraZeneca, Menarini, AstraZeneca, Menarini Research Funding (Inst.): Gilead Sciences Travel, Accommodations, Expenses: Gilead Sciences, Daiichi Sankyo Europe GmbH, Roche

Contributor: Alec Coston, MD Case Report Summary: A 17-year-old female involved in a motor vehicle collision presented to a rural emergency facility via personally operated vehicle. During workup and initial CT scan, the patient began rapidly decompensating with CT revealing a 1.5cm epidural hematoma with 7mm of midline shift. The patient went from being able to walk and talk to being obtunded with a blown left pupil and unresponsive. Following intubation, the patient was being prepared for transport but potential delays required immediate emergency evacuation of the hematoma via a Burr Hole. A traditional Burr Drill was not immediately available at the facility, so an improvised Burr Drill using an Intraosseous (IO) drill was used. 35mL of blood was removed from the hematoma and the patient immediately improved from a GCS of 3 to GCS of 8. The patient was transferred to a higher level of care facility, extubated the following day, and made a full neurological recovery.  Educational Pearls: What is an epidural hematoma? An epidural hematoma is a collection of blood between the dura mater (outermost layer of the meninges) and the skull, whereas a subdural hematoma is a collection of blood between the dura mater and arachnoid mater. Both can be life threatening depending on location and size. Epidural hematomas tend to be arterial, and are typically secondary to trauma and can rapidly expand, but with timely recognition and evacuation of the bleed, favorable outcomes are often possible. What are typical intracranial pressures and at what levels do they become pathologic? Typical intracranial pressure (ICP) varies by age, but past infancy and early childhood, adolescents and adults have a value typically between 8-15mmHg. Values exceeding 20mmHg become pathologic and rise exponentially with increased volume. Initial symptoms may include headache, nausea, and vomiting, but with increased pressures may progress to more life threatening symptoms such as loss of consciousness, cranial nerve palsies, pupillary constriction or dilation (sign of herniation), and respiratory irregularities. What is the takeaway in timing of epidural hematomas? Older studies show that evacuation of a hematoma with lateralizing features before the two hour mark of coma symptom onset is correlated with decreased mortality (ranging from 15-17%), but beyond 2 hours the mortality increases to well over 50%. Though mortality statistics have grown more variable, early targeted evacuation of epidural hematomas still remains critical for improved patient outcomes. In austere conditions with limited resources, improvisation with interosseous drills and needles can improve patient outcomes and achieve the target therapy for epidural hematomas. References Haselsberger K, Pucher R, Auer LM. Prognosis after acute subdural or epidural haemorrhage. Acta Neurochir (Wien). 1988;90(3-4):111-116. doi:10.1007/BF01560563 Hawryluk GWJ, Nielson JL, Huie JR, et al. Analysis of Normal High-Frequency Intracranial Pressure Values and Treatment Threshold in Neurocritical Care Patients: Insights into Normal Values and a Potential Treatment Threshold. JAMA Neurol. 2020;77(9):1150-1158. doi:10.1001/jamaneurol.2020.1310 Pisică D, Volovici V, Yue JK, et al. Clinical and Imaging Characteristics, Care Pathways, and Outcomes of Traumatic Epidural Hematomas: A Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury Study. Neurosurgery. 2024;95(5):986-999. doi:10.1227/neu.0000000000002982 Summarized by Dan Orbidan, OMS2 | Edited by Dan Orbidan and Jorge Chalit, OMS4 Donate: https://emergencymedicalminute.org/donate/

Full article: Central Tumor Location in Resected Lung Adenocarcinoma: Association with Recurrence and Survival Outcomes What is the association of tumor location with lung cancer outcomes? Antonino Andrea Blandino, MD, discusses the article by Ahn et al. exploring prognostic implications of central location for resected lung adenocarcinoma. 

Send us a textIn today's episode of PTs Snacks podcast, hosted by Kasey, we dive into the intricacies of high ankle sprains, also known as syndesmotic ankle sprains. We'll explore the relevant anatomy, common mechanisms of injury, diagnostic techniques, and treatment strategies. Kasey also highlights the importance of distinguishing high ankle sprains from other types of ankle injuries and discusses both non-surgical and surgical management approaches. Whether you're a seasoned physical therapist or a student, this episode is packed with valuable insights to enhance your clinical practice.00:00 Introduction to PTs Snacks Podcast00:19 Understanding High Ankle Sprains00:56 Anatomy Review: Syndesmotic Ligaments03:43 Mechanism of Injury05:29 Clinical Presentation and Diagnosis06:43 Stress Tests for High Ankle Sprains08:29 Imaging and Differential Diagnoses09:30 Treatment and Rehabilitation Stages11:43 Prognosis and Final Thoughts12:19 Special Offers and ConclusionGo to PT Final Exam using this link to access great studying options to conquer the NPTE!Support the showStay Connected! Make sure to hit follow now so you don't miss an episode! Got questions? Email me at ptsnackspodcast@gmail.com or leave feedback HERE. You can also join the email list HERE Need CEUs Fast?Time and resources short? Medbridge has you covered: Get over $100 off a subscription with code PTSNACKSPODCAST: Medbridge Students: Save $75 off a student subscription with code PTSNACKSPODCASTSTUDENT—a full year of unlimited access for less! Prepping for the NPTE? Get all the study tools you need to master it at PT Final Exam. Use code PTSnacks at checkout to get a discount! Want to Support the Show?Help me keep creating free content by: Sharing the podcast with someone who'd benefit. Contributing directly via the link...

Bridging the Gap: Taryn Hallam on Surgery, Pelvic PT, and Honest PrognosisFew people in the pelvic health world have shaped the field like Taryn Hallam. With decades of experience as a clinician, educator, and researcher, she has a unique ability to bridge research and clinical practice.In this episode, we cover:How Taryn's research background in Sydney shaped her pelvic PT lensWhy bridging the gap between surgeons and therapists matters for better outcomesThe importance of prognosticating honestly (and how imposter syndrome gets in the way)Her take on controversial practices like crunches during pregnancy and flow stop exercisesWhy lifelong learning, mentorship, and case studies are essential to growth in pelvic health

              “Spectrum” (Original Mix) – Alex O'Rion. (Solis Records).              “Ionia” (Original Mix) – Arqana. (Forensic).              “Lighthouse” (Extended Mix) – Acrobat. (SoundFocus).              “Shine” (Bulldozer (UK) Remix) – AKIVA. (Prognosis).              “Dance Atmosphere” (Original Mix) – Alex ByWhite. (Smart Phenomena Records).              “Tension” (Original Mix) – Civilian One. (Trip Records).              “Labyrinth” (Original Mix) – Ivadro. (Stellar Black).              “Mistake” (Mike Kohl Remix) – Federico Epis. (Manual Music).              “Relax” (Dimas Mixon Remix) – Hernan Serrao, Christian Antonioni. (OLD SQL).            “Luminous Waves” (Original Mix) – Phi Phi, Ignace Paepe. (Bonzai Progressive).            “Unconditional” (Extended Mix) – Pretty Pink. (Deep Woods).            “Love Gallery” (IGCIO Remix) – Sebas Ramos, Lucas Perdomo. (LuPS Records).            “Flyertalk” (Christian Smith 2024 Rework) – Christian Smith. (Bedrock).            “Lunar” (Original Mix) – Ivan Pogrebniak. (Monkey League).            “Chemical Dreams” (Original Mix) – Chris Cargo. (RKP).            “Musick” (Paul Fakos Remix) – Galgo, Javier Valencia. (Stripped Digital).            “Black Hole” (Extended Mix) – Helvetic Nerds. (Sirup Music/Enormous Tunes).            “Spherical” (Three Drives Remix) – IMGFriend. (Transpecta).            “Solace In Silence” (Remixes)(Allan Mcloud Remix) – Hobin Rude. (LuPS Records).            “Big Valley” (Original Mix) – Luca Pennunzio. (Balkan Connection South America).

Featuring an interview with Prof Xavier Leleu including the following topics: Introduction: Historical treatment advances in multiple myeloma (MM) (0:00) Contemporary treatment for patients with newly diagnosed MM who are eligible for transplant (13:18) Prognosis and life expectancy for patients with MM (19:39) Mechanistic differences among anti-CD38 monoclonal antibodies (27:05) Routes of administration of anti-CD38 monoclonal antibodies (30:21) Background and treatment of smoldering myeloma (41:05) Treatment for older patients with newly diagnosed MM who are not eligible for transplant (46:41) NCPD information and select publications

Sam Libby is a veteran healthcare investment banker and the founder of TCB Capital Advisors. After a long career, he's now dedicated to a single mission: making a real, tangible impact on patient care. Links: ⭐ Sponsored by Podcast10x - Podcasting agency for VCs - https://podcast10x.comTCB Capital Advisors website - https://www.tcbcapitaladvisors.com/Sam Libby on Linkedin - https://www.linkedin.com/in/sam-libby-b4530b48/

Pat Kellett, President of the St Louis Labor Council, joins Michael and Amy and comments on the Boeing strike in St Louis. He says that 'it's time' for Boeing to share their good fortunes with their workers in St Louis.

Learn more about Paths to Understanding at https://www.PathsToUnderstanding.org Join the Paths Network at https://www.PathsNetwork.org New mothers and their infants are more likely to die in the United States than in any European country. The life expectancy of the average American is closer to that of middle eastern or south American countries than counterparts in western or central Europe, and it's been decreasing. Physicians are concerned those trends will continue with federal cuts to healthcare and health research programs. Our guest in this episode of Challenge 2.0 will address those concerns- Seattle-area cardiologist Dr. Mark Vossler, who leads the group Physicians for Social Responsibility.

Send us a textThyroid Talk with Dr. Angela Mazza, DOShow Notes Episode 42; Recorded: 8-8-2025Help for HyperparathyroidismHost: Dr. Angela Mazza, DOCo-host: Dawn Sheffield I'm Dr. Angela Mazza, D.O., a thyroid, endocrine, and metabolism specialist with a private practice in Central Florida.  My goal for this podcast is to define and demystify the thyroid gland, and thyroid-related medical conditions.   Here's some of what we covered today, not necessarily in this order: ·        What are the parathyroid glands, and what do they do?·        Where are the four parathyroid glands located?·        Over-active and under-active parathyroid conditions, compared.·        Do parathyroid glands respond to lifestyle interventions?·        Prognosis and treatment options for hyperparathyroidism.·        How available, and how effective, are treatment options?·        And best of all we learned that we CAN impact our thyroid health!My book, Thyroid Talk: An Integrative Guide to Optimal Thyroid Health, is available on Amazon.  For information on the related Webinar and online master course, see thrivethyroid.com.  Or forward your name and email to thyroidtalk.mazza@gmail.com or to our website: metaboliccenterforwellness.com  The webinar coordinates with the online master class.  The master class has modules that cover topics like diagnosis of thyroid issues, personalized treatment, gut healing, and much more--plus some bonuses. Visit the Wellness Store at metaboliccenterforwellness.com regarding supplements mentioned in various episodes of this podcast.  Please stay in touch!  Send your comments, show ideas, and questions to thyroidtalk.mazza@gmail.com  We may disclose your general location on air (the city or town, for example), but we will NOT read your name NOR your address on the show.  We reserve the right to edit your input as necessary.  See the website at metaboliccenterforwellness.com; our YouTube channel (Dr. Angela Mazza), Facebook, and Instagram.   The topic of our next episode may still be in the planning stages as of this recording. Citations, references, additional information: mayoclinic.org.  Hyperparathyroidism.  Mayo clinic staff.  May 17, 2022.Mazza, A. Thyroid Talk: An Integrative Guide to Optimal Thyroid Health.  Available now on Amazon.Ask your healthcare provider about specific questions regarding your wellness.  This podcast is meant for educational purposes only.Copyright 2025 Dr. Angela Mazza DO.  Thyroid Talk with Dr. Angela Mazza, DO.  All rights reserved. MUSICCopyright 2025 Dr. Angela Mazza DO.  Thyroid Talk with Dr. Angela Mazza, DO.  All rights reserved.   Check out our YouTube channel - Dr. Angela Mazza, our website at Metabolic Center for Wellness, our FaceBook and our Instagram page.

00:00 – 13:34 – Kevin’s rocking a tank top and is disappointed in Marc, British Open, Fever lose to the Liberty and Caitlin Clark remains out, her status for the WNBA All-Star Game, 13:35 – 20:38 – Morning Checkdown 20:39 – 40:58 – The oldest Colt on the roster is surprising, he also appears to be the longest tenured Colt now without Ryan Kelly, NFL rookie contracts, if a team offered the Colts a second-round pick for Alec Pierce should the Colts take it?, Victor Oladipo reuniting with the Pacers?, Fever get smoked by the Liberty last night 40:59 – 1:03:47 – Colts VP of Communications Steve Campbell joins us to discuss the ramp up period to training camp and what is coming to Westfield, what fans can expect to see, one of the few NFL teams still doing training camp off-site, best position of strength on the roster, could Caitlin Clark participate in the 3-point contest and not the All-Star Game?, Stephanie White’s comment on the status of Clark heading into All-Star weekend, bison farms, Morning Checkdown 1:03:48 – 1:15:22– NFL Coach most likely to get fired first this season, Shane Steichen is 3rd on the list and is that fair?, who has the bigger hot seat: Shane Steichen vs. Chris Ballard 1:15:23 – 1:22:09 – Best case scenario for the Pacers next season 1:22:10 – 1:45:51 – Braden Smith’s high school coach and Westfield’s Shane Sumpter joins us to discuss Smith’s strengths, how he looked early on as a player and how he’s developed, his best quality, what he remembers about his recruiting, retiring his number, looking ahead to Westfield’s season, Morning Checkdown 1:45:52 – 1:57:59 – Indiana Fever sideline reporter Kelsie Kasper joins us after an insane day of travel, Caitlin Clark’s latest injury, the WNBA All-Star rule changes and which one she likes, Sydney Colson’s upcoming comedy gig 1:58:00 – 2:02:54 – Wrapping up the show: we give away state fair tickets, Kevin’s tank top jokesSupport the show: https://1075thefan.com/the-wake-up-call-1075-the-fan/See omnystudio.com/listener for privacy information.

In the future, medicine is very comprehensive and very accurate.Another story by Dr. Jeffrey A Robinson, based on a idea by Joseph A. Shiller.

On this episode of Translating Proteomics, Parag, Andreas, and special guest Don Kirkpatrick answer questions submitted by the Translating Proteomics community. They cover:Needs in plasma proteomicsHow proteomics impacts drug development – with special guest Don Kirkpatrick Ph.D.!How lifestyle impacts the proteomeHow the Nautilus Proteome Analysis Platform is impacting tau and Alzheimer's disease researchReferencesShome et al., 2022 - Serum autoantibodyome reveals that healthy individuals share common autoantibodieshttps://www.sciencedirect.com/science/article/pii/S2211124722006489LaBaer Lab paper investigating autoantibody levels in plasma and their relationship to health.Sylman et al., 2018 - A Temporal Examination of Platelet Counts as a Predictor of Prognosis in Lung, Prostate, and Colon Cancer Patientshttps://www.nature.com/articles/s41598-018-25019-1Mallick lab paper investigating temporal changes in platelets and their associations with cancer biology.Krönke et al., 2014 - Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cellshttps://www.science.org/doi/10.1126/science.1244851Seminal paper describing selective protein degradation caused by lenalidomide.Fink and Ebert 2015 - The novel mechanism of lenalidomide activityhttps://ashpublications.org/blood/article/126/21/2366/34644/The-novel-mechanism-of-lenalidomide-activityReview of research elucidating the mechanisms of lenalidomide activityNdoja et al., 2025 - COP1 Deficiency in BRAFV600E Melanomas Confers Resistance to Inhibitors of the MAPK Pathwayhttps://www.mdpi.com/2073-4409/14/13/975Describe links between kinase inhibitor vemurafenib and changes in ETV transcription factor degradationSong et al., 2022 - RTK-Dependent Inducible Degradation of Mutant PI3Kα Drives GDC-0077 (Inavolisib) Efficacyhttps://aacrjournals.org/cancerdiscovery/article/12/1/204/675622/RTK-Dependent-Inducible-Degradation-of-Mutant-PI3KUse proteomics to discover that inavolisib acts through selective degradation of mutant PI3KαCanon et al., 2019 - The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunityhttps://www.nature.com/articles/s41586-019-1694-1Covers the development of an inhibitor of KRAS mutant KRAS (G12C).Schneider et al., 2024 - Feeding gut microbes to nourish the brain: unravelling the diet-microbiota-gut-brain axishttps://www.nature.com/articles/s42255-024-01108-6Review on the gut-brain axisWebpage for Johanna Lampe's Lab at Fred Hutch Cancer Center

I'm never excited when I diagnose a cat with anaemia: vague signs, confusing diagnostics, and what feels like a not-so-great prognoses. But are they really that hopeless?In this episode, feline medicine specialist Dr Rachel Korman joins us demystify the anaemic cat and offer a clear, practical diagnostic framework that will give you more confidence and better outcomes the next time you see a cat with a low PCV.Some highlights from this conversation:A step-by-step approach to categorising anaemia.Regenerative vs. non-regenerative: what it actually means in cats, and how to interpret the data.Why IMHA in cats doesn't look like IMHA in dogs — and how to recognise it.Haemoplasma infections (like Mycoplasma):  When to treat, how to treat, PCR testing, and what the results really tell you.Age-specific differentials: what to prioritise in young vs. older cats.Supportive care: what works, what's myth.Prognosis pitfalls: why PCV alone doesn't predict survival.This episode will help you approach feline anaemia with more clarity, structure, and - dare we say - optimism.

Jeff Blair and Kevin Barker kick off the second hour with Los Angeles Dodgers President and CEO Stan Kasten (1:30). He discusses why so many Dodgers pitchers are getting hurt, how they mitigate the risks associated with Shohei Ohtani pitching, their rivalry with the Padres, and the challenge of managing multiple superstars for Dave Roberts. Then, Jeff and Kevin react to Blue Jays manager John Schneider's pregame availability, where he discussed Alek Manoah's progress and Yimi García's looming return. Finally, Jeff and Kevin go to the Back Leg Line to answer your calls and questions!The views and opinions expressed in this podcast are those of the hosts and guests and do not necessarily reflect the position of Rogers Sports & Media or any affiliates.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME information, and to apply for credit, please visit us at PeerView.com/AZC865. CME credit will be available until 19 June 2026.Navigating the Layers of Complexity in R/R B-Cell Cancers: From Clinical Prognosis to Emerging Therapeutic Prospects in CLL/SLL, MCL, and DLBCL In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME information, and to apply for credit, please visit us at PeerView.com/AZC865. CME credit will be available until 19 June 2026.Navigating the Layers of Complexity in R/R B-Cell Cancers: From Clinical Prognosis to Emerging Therapeutic Prospects in CLL/SLL, MCL, and DLBCL In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME information, and to apply for credit, please visit us at PeerView.com/AZC865. CME credit will be available until 19 June 2026.Navigating the Layers of Complexity in R/R B-Cell Cancers: From Clinical Prognosis to Emerging Therapeutic Prospects in CLL/SLL, MCL, and DLBCL In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME information, and to apply for credit, please visit us at PeerView.com/AZC865. CME credit will be available until 19 June 2026.Navigating the Layers of Complexity in R/R B-Cell Cancers: From Clinical Prognosis to Emerging Therapeutic Prospects in CLL/SLL, MCL, and DLBCL In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME information, and to apply for credit, please visit us at PeerView.com/AZC865. CME credit will be available until 19 June 2026.Navigating the Layers of Complexity in R/R B-Cell Cancers: From Clinical Prognosis to Emerging Therapeutic Prospects in CLL/SLL, MCL, and DLBCL In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME information, and to apply for credit, please visit us at PeerView.com/AZC865. CME credit will be available until 19 June 2026.Navigating the Layers of Complexity in R/R B-Cell Cancers: From Clinical Prognosis to Emerging Therapeutic Prospects in CLL/SLL, MCL, and DLBCL In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc.Disclosure information is available at the beginning of the video presentation.

In this podcast, Dr. Adam Khader (Richmond VA Medical Center & Assistant Professor at VCU School of Medicine) moderates a focused discussion with Dr. Jula Veerapong (UC San Diego Health) and Dr. Zachary Brown (NYU Langone Medical Center) on the clinical assessment and treatment of goblet cell carcinoma (GCC). The panel explores how evolving pathologic classifications impact management, the role of staging, and treatment considerations including systemic therapy and surgery. This episode provides practical, expert-driven insights for clinicians managing patients with this rare appendiceal malignancy.

Melodic Beats Podcast #140 Strange Malcolm. We welcome Strange Malcolm back to the podcast for over an hour of organically melodic house music. Its always an honour and pleasure to have steve back involved with MB following his releases on the label along with huge releases on Nick Warrens, The soundgarden, Prognosis, Perfecto Black, Hexagonal Records, Critical Elements, Massive Harmony and The Prog Lab to mention a few, along with one of the biggest labels out there for Organic House which will be announced in the coming weeks... A producer who never disapoints and a gentleman of the game.. As always play loud and enjoy !!!!   Tracklist:   Lasa (Original Mix) – JFR Stargazer – DAVI Mila – KatrinKa Symphonic Fantasy – Amonita / Makebo Melted (Original Mix) – Doyeq We Will Dance Again (Original Mix) – Shai T Elysian – Strange Malcolm Shadows – Dee Montero / Newman (I Love) Calys (Original Mix) – Raw Main My Gulyali Na Zare – M.O.S. Sowa – Tim Green No Drama Dance (Original Mix) – Maxi Degrassi Sunshine Hotel (Original Mix) – Sean Doron

Featuring perspectives from Dr Farshid Dayyani, Ms Caroline Kuhlman, Dr Philip A Philip and Ms Amanda K Wagner, including the following topics: Introduction: Initial Management of Pancreatic Adenocarcinoma (PAD) (0:00) Clinical Presentation and Prognosis of PAD; Recent Advances in Up-Front Treatment for Metastatic PAD (19:01) Selection and Sequencing of Therapy for Relapsed/Refractory Metastatic PAD (54:38) Importance of Palliative Care for Advanced PAD (1:06:09) Role of PARP Inhibitor Maintenance Therapy for Newly Diagnosed Metastatic PAD (1:14:59) Promising Investigational Strategies for PAD (1:26:56) NCPD information and select publications

In this episode, Dr. Zanotti discusses the science of hope. He's joined by Dr. Stephen Trzeciak, a physician-scientist, the Edward D. Viner Endowed Chief of Medicine at Cooper University Health Care, and Professor and Chair of Medicine at Cooper Medical School of Rowan University in Camden, New Jersey. Dr. Trzeciak is a practicing intensivist and a clinical researcher with more than 100 publications in the scientific literature. In addition, he is co-author of two excellent books: Wonder Drug: 7 Scientifically Proven Ways That Serving Others Is the Best Medicine for Yourself (2022) and Compassionomics: The Revolutionary Scientific Evidence that Caring Makes a Difference (2019). Additional resources: Recovery Expectations and Long-term Prognosis of Patients with Coronary Heart Disease Barefoot JC, et al. JAMA Internal Medicine 2011: https://pubmed.ncbi.nlm.nih.gov/21357800/ Optimism and Rehospitalization After Coronary Artery Bypass Graft Surgery. Scheler MF, et al. JAMA Int Med 1999: https://pubmed.ncbi.nlm.nih.gov/10219928/ The median is not the message. By Jay Gould: https://journalofethics.ama-assn.org/sites/joedb/files/2018-05/mnar1-1301.pdf Books mentioned in this episode: Man's Search for Meaning. By Viktor E. Frankl: https://bit.ly/3SqsNyt Wonder Drug: 7 Scientifically Proven Ways That Serving Others Is the Best Medicine for Yourself. By Stephen Trzeciak and Anthony Mazzarelli: https://bit.ly/4kiyA5q Compassionomics: The Revolutionary Scientific Evidence that Caring Makes a Difference. By Stephen Trzeciak and Anthony Mazzarelli: https://bit.ly/43ul5IE

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Prevalence, Risk Factors, and Prognosis for Fontan-Associated Liver Disease: A Systematic Review and Exploratory Meta-Analysis.

This week, YHA CEO Paul McGrath talks about being diagnosed with lymphoblastic leukemia at age 39, why working harder to get ahead is BS and he outlines the three key elements of successful transformation. This podcast is sponsored by Aussie Broadband.See omnystudio.com/listener for privacy information.

In our first hour this morning, we give you "Five Things" that you need to know this AM -- and we discuss Joe Biden's prostate cancer diagnosis.

Drs. Bose and Pemmaraju review secondary myelofibrosis arising from polycythemia vera or essential thrombocythemia and how it differs from primary myelofibrosis that develops de novo.

Our main focus today was on nudging critical care clinicians to consider a more palliative approach to care.  Our guests are all trained in critical care: Kate Courtright, Scott Halpern, and Jaspal Singh.  Kate and Scott have additional training in palliative medicine.  To start. we review: What is a nudge? Also called behavioral interventions, heuristics, and cognitive biases. Prior podcasts on the ethics of nudging, and a different trial conducted by Kate and Scott in which the default for hospitalized seriously ill patients was to receive a palliative care consult. What is sludge?  I'd never heard the term, perhaps outside of Eric's pejorative reference to my coffee after adding copious creamers, flavoring, and sweeteners.  Sludge is apparently when you create barriers or extra work for someone.  For example, putting the healthy food at the back of the grocery store is sludge; making an applicant for health insurance climb the flight of stairs to the office - weeding out those less fit - is also sludge.  Prior-auth forms? Sludge. Examples of nudges, some based in health care, others in coffee.  This specific study, published in JAMA Internal Medicine, was conducted in 17 ICUs in North Carolina. Many were community hospitals.  Participants were critically ill and intubated.  Clinicians were randomized to 4 groups: Usual care Prognosis nudge - EHR prompt asking, do you think your patient will be alive in 6 months? This is called a focusing effect Comfort care nudge - EHR prompt asking if they'd offered comfort-focused care. This is called accountable justification - an appeal to standards of care for critically ill patients endorsed by multiple professional societies. Both the prognosis and comfort care nudge. A few key points of discussion: Is an EHR prompt a nudge or sludge?   The intervention was a negative study for the primary outcome, hospital length of stay.  Why?  The prognosis nudge did nothing.  What to make of that? Would you think an EHR nudge to consider prognosis might move the needle, at least on some outcomes? The nudge toward offering comfort care led to more hospice and early comfort-care orders.  Is this due to chance alone, given the multiplicity of secondary outcomes examined?  Or is it a tantalizing finding that suggests a remarkably low cost EHR based nudge might, on a population level, lead to critical care clinicians offering comfort care and hospice more frequently?  Imagine!    -Alex Smith  

In this episode I am joined by Tulku Sherab Dorje, Buddhist teacher, translator, and author of scholarly and popular books about Tibetan Buddhism. Tulku Sherdor reflects on the changes in the spiritual journey over a lifetime, whether or not the world is becoming more turbulent, and the effects of ageing on yogic practice and view. Tulku Sherdor explains why mind training is superior to mystical experiences, emphasises the reality of impermanence, and shares the best tests of successful retreat and spiritual growth. Tulku Sherdor also warns about the prognosis of tulkus who do not conduct extensive retreat; critiques the shortcomings of the 3-year retreat model as conducted in the West; and details the temptations for dharma teachers in pleasure, profit, praise, and popularity. … Video version: https://www.guruviking.com/podcast/ep304-crumbs-from-the-parrots-beak-tulku-sherdor Also available on Youtube, iTunes, & Spotify – search ‘Guru Viking Podcast'. … Topics include: 00:00 - Intro 01:04 - Crumbs from the Parrot's Beak 02:43 - The spiritual journey and the phases of life 04:24 - Is the world becoming more turbulent? 05:56 - The effects of ageing on spiritual practice 07:53 - How to relate to physical limitations 09:56 - Ambition for enlightenment 12:26 - This is more fundamental than Bodhicitta 13:23 - Reality of impermanence 15:20 - The unique challenges of intensive practice and retreat 18:39 - Distinguishing appearance from substance 19:41 - The title “lama” is not a guarantee of quality 21:12 - The best proof of progress 23:17 - The role of a demanding retreat schedule 26:24 - Mature practice 28:03 - Tulkus must conduct extensive retreat but sometimes don't 30:28 - Prognosis for high lamas who don't do extensive retreat 32:30 - Hopes for corrections in the tulku system 34:58 - The Tibetan Buddhist tradition is unique and precious 35:41 - Signs of a successful retreat 38:01 - Completing a 3 year retreat is not a guarantee of quality 38:56 - Substandard Western 3 year retreats 40:49 - Pre-1950s Tibet and the renunciate yogi system 46:11 - Today's economic challenges when practicing the dharma 49:47 - Mind training is superior to glimpses of the nature of mind 55:45 - The best test of success in practice 57:00 - Does practice ever get easier? 01:01:28 - The 4 payoffs: pleasure, profit, praise, popularity 01:06:49 - Guru devotion and the guru relationship 01:12:31 - A story about Dilgo Khyentse Rinpoche 01:14:41- Peace Prayer Gathering in June 2025 … Previous episode with Tulku Sherdor: - https://www.guruviking.com/podcast/ep276-canadian-tulku-translator-tulku-sherab-dorje To find our more about Tulku Sherdor, visit: - https://blazingwisdom.org/tulku-sherab-dorje/ - https://dharmakayacenter.org/all-programs/2637/sadhana-practice-expanding-our-compassion-for-all-beings/?fbclid=IwY2xjawKAGaRleHRuA2FlbQIxMABicmlkETFXZEJ2cmRmb0U3VTExUWpmAR729nsWXoI6VZEb9GkrzCeajdhS6ze_zGrQZUTvLpsphQJQHPSdJABxQ0brag_aem_dWMYHIGmMRk_dxeWxEuL7A For more interviews, videos, and more visit: - https://www.guruviking.com Music ‘Deva Dasi' by Steve James

Dr. Crow from Chippewa Valley Orthopedics and Sports Medicine gives us a timeline on the Dame injury. See omnystudio.com/listener for privacy information.

  On this episode of Unsupervised Learning Razib talks to Matt Welch. He co-founded the Prague-based newspaper Prognosis in the early 1990's and later worked as an opinion section editor for the Los Angeles Times. From 2008-2016, Welch served as editor-in-chief of Reason magazine, where he currently holds the position of editor-at-large. He co-authored The Declaration of Independents: How Libertarian Politics Can Fix What's Wrong with America and wrote McCain: The Myth of a Maverick. Today, Welch co-hosts The Fifth Column podcast with Kmele Foster and Michael Moynihan. Razib and Welch first go back to his days in Eastern Europe, and how they shaped his views on foreign policy, making him somewhat heterodox for someone whose primary political inclinations favor libertarianism. Welch discusses how wild, hopeful and chaotic the 1990's were in the former Eastern Bloc after the fall of the Iron Curtain and the end of Communism. He also argues that these nations had strong historic and contemporary geopolitical reasons to fear the former Soviet Union, and so pushed for the eastward expansion of NATO. Razib makes the Russian case that its turn away from the West in the 2000's was in response to America's strategy of encirclement, but Welch dismisses this as Russian revisionism. He believes that at the end of the day Soviet-era elites retained an imperial attitude toward Eastern and Central Europe rooted in a centuries-long assumption of Russian hegemonic status in the region. Next, retreating from abstruse foreign policy, Razib and Welch discuss the early days of the blogosphere, in 2001/2002. Then, Welch coined the term “warblogger,” and envisaged a scenario where post-partisan citizen-journalists would play an essential role in the information ecosystem of the 21st century. He discusses his disappointment with the reemergence of partisanship within the blogosphere, as well as the disappointments of post-9/11 interventionism. Welch also talks about the Tea Party, and its connection, and ultimate disconnect, from libertarianism. They also discuss how the Tea Party energy was eventually transferred to the ideologically heterodox and often anti-libertarian Trump movement. Finally, Welch talks about his latest primary venture, the successful The Fifth Column podcast. Razib asks if the current age of podcasting is analogous to the early blogosphere. Welch talks about how organically and gradually The Fifth Column came into being, and the growing pains with greater professionalization. He also addresses their future on The Fifth Column, with a new shift toward video, while continuing the informal and candid nature of the discussions.

Chasing the ‘perfect’ diet is a trap; which is really great news for our brand. Simon Hill, nutritionist, physiotherapist, and host of The Proof podcast, joins us in the Academy of Imperfection to break down whether the latest dietary trends on social media actually match up with nutrition science. In this episode, Simon unpacks the role of both genetics and lifestyle choices in shaping our health, and specifically our risk of disease. Acknowledging the pressure, and sometimes shame, that comes with chasing the ‘perfect’ diet, Hugh, Ryan, and Josh discuss how to encourage kids to build positive relationships with food, and the incredible significance of ‘joy’ and ‘human connection’, that occurs when we get together to eat. And then, of course, we play Simon Says and bust some food-myths about supplements, plant protein, and whether breakfast is the most important meal of the day. Simon, thank you for all that you says. To watch this full episode on YouTube, follow this link: https://bit.ly/4jyH2NL

Concern about inequality is fine but will our government re-distribute income? What exactly do we propose to solve unemployment?The Congress has a history of 140 years and the BJP just 45, but does today's youth care? Shashi Tharoor asks probing questions but Gandhi's Congress won't answer. ThePrint Political Editor DK Singh explains why. --------------------------------------------------------------------------------------------- To visit ThePrint Store: https://store.theprint.in/ --------------------------------------------------------------------------------------------- Produced by: Mahira Khan

Send us a textTom Willard from Minnesota suffered his heart attack on October 16th, 2024 and as a flight attendant for a major airline realizes how fortunate he is that he wasn't working and in the air when his heart attack symptoms suddenly appeared.  Thanks to his experience working as an X-ray technician, Tom quickly recognized his symptoms and was able to not only get himself quickly to the ER, but he was able to clearly articulate what he was experiencing which quite likely saved his life!Like many, Tom struggled in the early days, but after some advice from a friend who had also had a near death experience, Tom realized his heart attack was a chance to completely transform his life and well being as he now is fully living a whole food plant based lifestyle!Podcast Disclaimer:The information and opinions presented in the Heart Attack Thriver Podcast is not intended as, and shall not be understood or construed as, medical advice. While the information provided on this Podcast relates to medical issues, and health and wellness, the information is not a substitute for medical advice from a Medical Professional who is aware of the facts and circumstances of your individual situation.#heartattack #heartattacksurvivor #heartattackprevention #awarenessiseverything #knowthesigns #knowthesymptoms #knowyourfamilyhistory #listentoyourbody #itsnotalwaystextbooksymptoms #seekhelpimmediately #breathe #listentoyourheart #listentoyourbody #theheartattackthriver #theheartthriverpodcastThank you for listening and please be sure to hit “SUBSCRIBE”, and “SHARE” this podcast with anyone that you feel could benefit from it.If you'd like to reach me for support or to leave a comment or feedback, please send an email to: heartattackthriver@icloud.com

Polycystic kidney disease is the most common genetic kidney disease worldwide and is characterized by progressive development of kidney cysts. Author Nerra Dahl, MD, PhD, Mayo Clinic, discusses the pathophysiology, clinical presentation, diagnosis, prognosis, and treatment of ADPKD in adults, with JAMA Associate Editor David Simel, MD, MHS. Related Content: Autosomal Dominant Polycystic Kidney Disease

Prof. Sarah Camargos interviews Prof. Sun Ju Chung about his recent paper in the Movement Disorders Journal investigating diagnostic and prognostic capabilities of measuring blood mitochondrial DNA copy number (mtDNA-CN) for Parkinson's disease. Journal CME is available until March 3, 2026 Read the article.

  What if the key to advancing military medicine lies in a small shift from opioids to ketamine for battlefield pain management? Join us as we unlock the groundbreaking research of Dr. Ted Melcer, a pioneer in military psychological studies, whose work challenges the conventional use of morphine for wounded soldiers. Recognized by Military Medicine Journal as the 2024 article of the year, Dr. Melcer's investigation into pre-hospital ketamine therapy offers fresh insights into its potential to alter PTSD prognosis, shifting the landscape of tactical combat care. As we delve into Dr. Melcer's journey, we explore the evolution of his research since before 9/11, highlighting the urgent need for data-driven medical care enhancements for troops in conflict zones. Discover how the Naval Health Research Center's innovative database initiative has informed new treatment protocols, possibly reducing psychological repercussions for soldiers. This episode promises a thorough exploration of the strategic, long-term benefits of ketamine use in military medicine and the broader implications for operational readiness. Dr. Melcer's research publication was selected as the AMSUS Journal Military Medicine Article of the Year for 2025. Article Citation: Is Prehospital Ketamine Associated With a Change in the Prognosis of PTSD? Ted Melcer, PhD, G Jay Walker, BA, Judy L Dye, NP, Benjamin Walrath, MD, MPH, Andrew J MacGregor, PhD, Katheryne Perez, MPH, Michael R Galarneau, MS, NRERMT Military Medicine, Volume 188, Issue 7-8, July/August 2023, Pages e2165–e2174, https://doi.org/10.1093/milmed/usac014     Take Home Messages: Revolutionizing Battlefield Pain Management: The transition from traditional opioids to low-dose ketamine for managing pain in combat situations shows promising results, potentially offering safer alternatives with fewer side effects, especially for soldiers who have sustained severe injuries. Impact on PTSD Prognosis: Preliminary findings suggest that the use of pre-hospital ketamine may be associated with lower odds of developing PTSD compared to opioids, indicating a protective psychological benefit for injured service members. Importance of Tactical Combat Casualty Care Guidelines: The research highlights the critical role of tactical combat casualty care guidelines in informing first responders and medics about effective pain management strategies that may also enhance long-term psychological outcomes. Value of Battlefield Data: The collection and analysis of battlefield casualty care data are invaluable for understanding the effects of medical interventions on long-term health outcomes, informing both military guidelines and broader medical practices. Continuous Need for Research: There is a pressing need for systematic studies on the long-term psychological effects of battlefield treatments, emphasizing the importance of ongoing research to improve rehabilitation outcomes and operational readiness for service members.   Episode Keywords: Battlefield medicine, ketamine research, PTSD treatment, military healthcare, WarDocs podcast, pain management, soldier recovery, innovative medicine, combat healing, mental health, Dr. Ted Melcer, Naval Health Research Center, Military Medicine Journal, tactical combat casualty care, operational readiness, psychological effects, opioid alternatives, military medicine, AMSUS, trauma registry, pre-hospital care.   Hashtags: #BattlefieldMedicine #KetamineResearch #PTSDTreatment #MilitaryHealthcare #WarDocsPodcast #PainManagement #SoldierRecovery #InnovativeMedicine #CombatHealing #MentalHealthRevolution   Honoring the Legacy and Preserving the History of Military Medicine The WarDocs Mission is to honor the legacy, preserve the oral history, and showcase career opportunities, unique expeditionary experiences, and achievements of Military Medicine. We foster patriotism and pride in Who we are, What we do, and, most importantly, How we serve Our Patients, the DoD, and Our Nation.   Find out more and join Team WarDocs at https://www.wardocspodcast.com/ Check our list of previous guest episodes at https://www.wardocspodcast.com/our-guests Subscribe and Like our Videos on our YouTube Channel: https://www.youtube.com/@wardocspodcast Listen to the “What We Are For” Episode 47. https://bit.ly/3r87Afm   WarDocs- The Military Medicine Podcast is a Non-Profit, Tax-exempt-501(c)(3) Veteran Run Organization run by volunteers. All donations are tax-deductible and go to honoring and preserving the history, experiences, successes, and lessons learned in Military Medicine. A tax receipt will be sent to you. WARDOCS documents the experiences, contributions, and innovations of all military medicine Services, ranks, and Corps who are affectionately called "Docs" as a sign of respect, trust, and confidence on and off the battlefield,demonstrating dedication to the medical care of fellow comrades in arms.     Follow Us on Social Media Twitter: @wardocspodcast Facebook: WarDocs Podcast Instagram: @wardocspodcast LinkedIn: WarDocs-The Military Medicine Podcast YouTube Channel: https://www.youtube.com/@wardocspodcast

Can Baseline MRI Findings Identify Who Responds Better to Early Surgery Versus Exercise and Education in Young Patients With Meniscal Tears? A Subgroup Analysis From the DREAM Trial Clausen S, Boesen M, Thorlund JB, et al. J Orthop Sports Phys Ther. Published online January 30, 2025:1-23. doi:10.2519/jospt.2025.12994 Due to copyright laws, unless the article is open source we cannot legally post the PDF on the website for the world to download at will. Brought to you by our sponsors at: CSMi – https://www.humacnorm.com/ptinquest Learn more about/Buy Erik/Jason/Chris's courses – The Science PT Support us on the Patreons! Music for PT Inquest: “The Science of Selling Yourself Short” by Less Than Jake Used by Permission Other Music by Kevin MacLeod – incompetech.com: MidRoll Promo – Mining by Moonlight Koal Challenge – Sam Roux