POPULARITY
237 episodes with basic science
16 episodes with basic science
5 episodes with basic science
8 episodes with basic science
7 episodes with basic science
90 episodes with basic science
4 episodes with basic science
7 episodes with basic science
4 episodes with basic science
4 episodes with basic science
4 episodes with basic science
6 episodes with basic science
2 episodes with basic science
4 episodes with basic science
6 episodes with basic science
4 episodes with basic science
3 episodes with basic science
2 episodes with basic science
Gudrun talks with Debajyoti Choudhuri. He is staying at KIT as a short term guest. He is Associate Professor in the School of Basic Sciences at IIT Bhubaneswar, India. He did his M.Sc. and Ph.D. in Mathematics at the University of Hyderabad. His research interest lies in the analysis of elliptic PDEs using Functional Analytic and topological methods. In this he touches and has a slight overlap with the research of Gudrun. The conversation starts with the discussion about a small paper which Debajyoti put on the archiv. It is about understanding how to work with the Fractional Laplacian. This means extending the classical Laplace operator Δ to non-integer powers. This operator is the main part in PDEs which model, e.g, anomalous diffusion, probability theory, image processing, finance, and nonlocal mechanics. (-Δ)s, where 0 < s < 1. What makes It different to the ordinary Laplacian? While the traditional Laplace operator is local, i.e. it depends only on values of u and its derivatives near x, the fractional Laplacian is nonlocal, it depends on values of u everywhere in space. Thus, for the analytical and numerical treatment one needs very different methods. There are several possible definitions. Some of them can be found in the Wikipedia article which is cited below. On ℝn, the cleanest definition is the Fourier definition which follows the idea: Take the Fourier transform. Multiply by |ξ|2s. Transform back. In the short paper which is discussed the singular integral definition is used: For 0 < s < 1: (-Δ)^s u(x) = C(n,s) PV ∫ [u(x) - u(y)] / |x - y|^(n + 2s) dy This makes the nonlocality explicit: every point y contributes to the value at x. The method central in studying Laplace problems is variational. It considers an (infinite) family of generalised problems and works on the existence of so-called weak solutions. These problems are formulated with the help of Sobolev spaces. The weak solution for the Laplace problem is an element of the space H1=W1,2. This means the solution and its (generalised) gradient are bounded in L2 in the domain in which the problem is solved. This has physical meaning and due to known properties (embedding) of Sobolev spaces the pointwise (strong) solutions often can be constructed when enough regularitiy of the weak solutions is proved. Fractional Laplacians naturally live in fractional Sobolev spaces. These are not that easy to connect to physical properties and a few of the equivalent definitions in the context of classical Sobolev spaces are not equivalent any more everywhere. Common approaches for numerics for PDEs including the fractional Laplacian are: Fourier spectral methods (periodic domains) Finite element methods for fractional PDEs Matrix-function methods (As) Caffarelli–Silvestre extension methods Quadrature approximations of singular integrals The Extension trick introduced by Caffarelli and Silvestre in 2007 (their original paper is cited below) is also discussed as part of the short note. p-laplacian augurs well in the sense because the unicity of the definitions of the s-laplacian is still lacking. The conversation then turns to how Debajyoti found his way into mathematics and the topic of PDEs and how life and work feel like in his university. More information: Webpage of Debajyoti Choudhuri Debajyoti Choudhuri: A quick sneak-peek at the s-fractional Laplacian operator (2022) Wikipedia on the Fractional Laplace operator Mateusz Kwaśnicki: Ten equivalent definitions of the fractional Laplace operator (2015) E. Di Nezza, G. Palatucci, E. Valdinoci, Hitchhiker's guide to the fractional Sobolev spaces, Bull. Sci. Math., 136(5), 521–573 (2012) L. Caffarelli, L. Silvestre, An extension problem related to the fractional Laplacian, Communications in Partial Differential Equations, 32, 1245–1260 (2007)
Gudrun talks with Debajyoti Choudhuri. He is staying at KIT as a short term guest. He is Associate Professor in the School of Basic Sciences at IIT Bhubaneswar, India. He did his M.Sc. and Ph.D. in Mathematics at the University of Hyderabad. His research interest lies in the analysis of elliptic PDEs using Functional Analytic and topological methods. In this he touches and has a slight overlap with the research of Gudrun. The conversation starts with the discussion about a small paper which Debajyoti put on the archiv. It is about understanding how to work with the Fractional Laplacian. This means extending the classical Laplace operator Δ to non-integer powers. This operator is the main part in PDEs which model, e.g, anomalous diffusion, probability theory, image processing, finance, and nonlocal mechanics. (-Δ)s, where 0 < s < 1. What makes It different to the ordinary Laplacian? While the traditional Laplace operator is local, i.e. it depends only on values of u and its derivatives near x, the fractional Laplacian is nonlocal, it depends on values of u everywhere in space. Thus, for the analytical and numerical treatment one needs very different methods. There are several possible definitions. Some of them can be found in the Wikipedia article which is cited below. On ℝn, the cleanest definition is the Fourier definition which follows the idea: Take the Fourier transform. Multiply by |ξ|2s. Transform back. In the short paper which is discussed the singular integral definition is used: For 0 < s < 1: (-Δ)^s u(x) = C(n,s) PV ∫ [u(x) - u(y)] / |x - y|^(n + 2s) dy This makes the nonlocality explicit: every point y contributes to the value at x. The method central in studying Laplace problems is variational. It considers an (infinite) family of generalised problems and works on the existence of so-called weak solutions. These problems are formulated with the help of Sobolev spaces. The weak solution for the Laplace problem is an element of the space H1=W1,2. This means the solution and its (generalised) gradient are bounded in L2 in the domain in which the problem is solved. This has physical meaning and due to known properties (embedding) of Sobolev spaces the pointwise (strong) solutions often can be constructed when enough regularitiy of the weak solutions is proved. Fractional Laplacians naturally live in fractional Sobolev spaces. These are not that easy to connect to physical properties and a few of the equivalent definitions in the context of classical Sobolev spaces are not equivalent any more everywhere. Common approaches for numerics for PDEs including the fractional Laplacian are: Fourier spectral methods (periodic domains) Finite element methods for fractional PDEs Matrix-function methods (As) Caffarelli–Silvestre extension methods Quadrature approximations of singular integrals The Extension trick introduced by Caffarelli and Silvestre in 2007 (their original paper is cited below) is also discussed as part of the short note. p-laplacian augurs well in the sense because the unicity of the definitions of the s-laplacian is still lacking. The conversation then turns to how Debajyoti found his way into mathematics and the topic of PDEs and how life and work feel like in his university. More information: Webpage of Debajyoti Choudhuri Debajyoti Choudhuri: A quick sneak-peek at the s-fractional Laplacian operator (2022) Wikipedia on the Fractional Laplace operator Mateusz Kwaśnicki: Ten equivalent definitions of the fractional Laplace operator (2015) E. Di Nezza, G. Palatucci, E. Valdinoci, Hitchhiker's guide to the fractional Sobolev spaces, Bull. Sci. Math., 136(5), 521–573 (2012) L. Caffarelli, L. Silvestre, An extension problem related to the fractional Laplacian, Communications in Partial Differential Equations, 32, 1245–1260 (2007)
In this episode, Ayesha and Andrew discuss the June 17, 2026 issue of JBJS, along with an added dose of entertainment and pop culture. Listen at the gym, on your commute, or whenever your case is on hold! Link: JBJS website: https://jbjs.org/issue.php Sponsor: This episode is brought to you by JBJS Clinical Classroom. Subspecialties: Orthopaedic Essentials, Hip, Basic Science, Spine, Infection, Foot & Ankle, Education & Training, Shoulder Chapters (00:00:02) - Your Cases On Hold(00:01:42) - Top 10 in Orthopedic Surgery: The Legacy of Aaron Rosenberg(00:06:38) - Robinson on Research Expectations(00:18:12) - The role of research in the medical student curriculum(00:19:09) - Residency and the role of research in surgery(00:21:02) - Bone metabolic activity after total hip arthroplasty(00:29:19) - Periprosthetic Joint Infection after total knee arthropl(00:40:37) - Patients with pneumonia after total knee arthroplasty(00:48:57) - Deep Learning System for Lengthy Classification in Adolescent Idiopath
In this episode, Jamie Wilson, MD, FRCS, MSc interviews Christopher Ahuja, MD, PhD, FRCSC, FAANS and Michael Fehlings, MD, PhD, FRCSC, about the challenges of sustaining a research career alongside a demanding spine surgery practice. They discuss how long timelines for scientific discovery, frequent setbacks in research, and competing clinical responsibilities can contribute to burnout. The conversation highlights strategies for maintaining motivation, including focusing on incremental progress, setting meaningful milestones, and protecting time for work, family, and personal well-being.
Host Dave Schlom is joined by science educator and author Trisha Muro to discuss her new book, It's (Just) Rocket Science: Exploring Physics Through Spaceflight Missions.
In this episode, Ayesha and Andrew discuss the May 20, 2026 issue of JBJS, along with an added dose of entertainment and pop culture. Listen at the gym, on your commute, or whenever your case is on hold! Link: JBJS website: https://jbjs.org/issue.php Sponsor: This episode is brought to you by JBJS Clinical Classroom. Subspecialties: Knee, Hip, Shoulder, Basic Science, Foot & Ankle, Orthopaedic Essentials, Education & Training Chapters (00:00:02) - Case Is On Hold(00:01:48) - Clopidogrel Thromboprophylaxis in(00:11:33) - Clopidogrel vs Aspirin post-operative bleeding(00:15:26) - Custom 3-D acetabular implants for complex revision total lip(00:22:29) - Custom Implants(00:25:12) - Satisfied but Failed: Total Knee Arthroplasty(00:37:15) - CMS' new criteria for knee replacements(00:41:00) - medial unicompartmental knee arthroplasty, adverse outcomes(00:43:12) - medial unit compartmental knee arthroplasty
In this episode of the Crazy Wisdom Podcast, host Stewart Alsop sits down with Joshua Bate, founder of Bonfires.ai and DeciWorld, for a wide-ranging conversation covering knowledge management, graph technology, ontologies, decentralized science, and the future of how humans organize and share information. They break down the differences between personal and enterprise knowledge management, explore why flat ontological graphs may be the key to making diverse knowledge bases interoperable, and get into why traditional RAG systems break down at scale and how graph RAG offers a more principled solution. The conversation expands into the philosophy of categorization, the slow death of basic "gentleman science" under institutional pressures, and how decentralized protocols might restore a kind of mycelial knowledge network connecting small groups of researchers, enthusiasts, and communities — much like the original spirit of the encyclopedia before it was co-opted by institutions. You can learn more about Joshua's work at bonfires.ai and deci.world or follow him on X at @Bonfiresai and @DeSciWorld.Timestamps00:00 - Stewart introduces Joshua Bate, founder of Bonfires.ai, discussing personal versus enterprise knowledge management and their fundamental differences at scale.05:00 - Joshua explains ontologies as classifiers for knowledge structures, describing their two-year search for a perfect ontology and ultimately building a flat, ontology-less graph protocol.10:00 - Stewart connects categorization to shamanic practice and intercategorical theory, noting how major companies like Netflix and Yahoo built graph-based ontologies while the discipline remains underappreciated philosophically.15:00 - Joshua traces Bonfires origins through decentralized science, explaining how NFT community excitement inspired redirecting capital toward funding unconventional researchers locked out of institutional systems.20:00 - Joshua describes building federated knowledge networks through hackathons and conferences, comparing the vision to what Wikipedia could have been with decentralized incentive structures.25:00 - Discussion shifts toward inevitable collapse of rigid scientific institutions, debating patchwork age theory, nation-state fragmentation, and rhizomatic versus arboreal knowledge structures.30:00 - Joshua articulates the mycelial network vision, enabling direct cross-cultural information access where individuals control their own narrative lens, warning against collective we thinking and authoritarianism.Key Insights1. Knowledge management exists on a spectrum from personal to enterprise, but the founder of Bonfires argues this split is artificial. He believes knowledge itself does not respect those boundaries, and that small groups, researchers, hobbyists, and large institutions all possess knowledge that can and should interoperate with each other.2. After two and a half years of searching for the perfect ontology to structure their knowledge graph, the team concluded that no perfect ontology exists. Their solution was to build the flattest possible graph structure with only events, entities, and edges, creating a base layer others can build specialized ontologies on top of.3. Graph-based knowledge systems are more efficient than traditional databases for AI traversal because once a graph is computed, it is relatively free to query. Graph RAG combines the discovery power of vector search with the structured precision of graph traversal, solving many hallucination problems associated with standard retrieval augmented generation.4. Basic scientific research, the soil from which applied discoveries grow, is deteriorating because institutional funding structures only reward commercially viable outcomes. The founder built his platform partly to redirect community-driven capital toward researchers who are doing important work without institutional support.5. The institutionalization of science has historically blocked the open exchange of ideas that drove the original scientific revolution. The human spirit for open inquiry has not changed, but people cannot pursue it without financial support, and building decentralized infrastructure could restore that possibility.6. A federated knowledge network would allow individuals to access information from any contributor and filter it through their own preferred lens, rather than receiving information pre-filtered by centralized platforms. This represents a form of information symmetry similar to how mycelial networks distribute nutrients across a forest.7. The concern is not whether current scientific and governmental institutions will change but in what direction the rebuilding goes. Those capitalizing on the transition carry the same incentives as the previous era, which risks reproducing the same problems inside new structures.
In this episode, Ayesha and Andrew discuss the May 6, 2026 issue of JBJS, along with an added dose of entertainment and pop culture. Listen at the gym, on your commute, or whenever your case is on hold! Link: JBJS website: https://jbjs.org/issue.php Sponsor: This episode is brought to you by JBJS Clinical Classroom. Subspecialties: Trauma, Hand & Wrist, Knee, Infection, Shoulder, Orthopaedic Essentials, Basic Science, Hip Chapters (00:00:02) - JBJS: Your Case Is On Hold(00:03:03) - The January 2017 Issue(00:04:17) - Enoxaparin vs Aspirin for Thrombop(00:08:31) - Aspirin vs Enoxaparin: Cost and Quality of(00:13:51) - Thromboprophylaxis after trauma 1, cost effectiveness(00:18:37) - Highly Cross Linked Polyethylene vs Conventional Interventional K(00:25:18) - Fix It or No Fix(00:26:15) - Primary and Secondary Analysis of the Fix IT Study(00:33:10) - External fixation vs internal fixation: does it matter?(00:39:18) - Created: Dedicated Trauma Room for Hand Surgery(00:42:12) - Hand Surgery Wait Time in Canada
In this short podcast, I discuss the upcoming 25 Hour USMLE Step 1 Basic Science Review starting at 5.45 pm EST each day from 5/12-16, 2026 over zoom. The review will be incredibly clinical, focus on integrations, help you understand pathophysiology, and expose you to a large amount of the Step 1 content. This class … Continue reading 25 Hour Step 1 Basic Science Review (Starts May 12, 2026)
In this short podcast, I discuss the upcoming 25 Hour USMLE Step 1 Basic Science Review starting at 5.45 pm EST each day from 5/12-16, 2026 over zoom. The review will be incredibly clinical, focus on integrations, help you understand pathophysiology, and expose you to a large amount of the Step 1 content. This class … Continue reading 25 Hour Step 1 Basic Science Review (Starts May 12, 2026)
Azim Surani, Director of Research at the Gurdon Institute and Professor Emeritus at University of Cambridge, received the Kyoto Prize in Basic Sciences, specifically in the field of Life Sciences and Medicine, for his work in demonstrating how male and female mammalian genomes receive distinct imprints during germ cell development. Genomic imprinting introduced a novel concept to Mendelian genetics and is a now fundamental principle in the life sciences. Surani's research has contributed to developmental biology and epigenetics, along with a wide range of life science fields including physiology, regenerative medicine, reproductive medicine, and plant science. Series: "Kyoto Prize Symposium" [Science] [Show ID: 41117]
Azim Surani, Director of Research at the Gurdon Institute and Professor Emeritus at University of Cambridge, received the Kyoto Prize in Basic Sciences, specifically in the field of Life Sciences and Medicine, for his work in demonstrating how male and female mammalian genomes receive distinct imprints during germ cell development. Genomic imprinting introduced a novel concept to Mendelian genetics and is a now fundamental principle in the life sciences. Surani's research has contributed to developmental biology and epigenetics, along with a wide range of life science fields including physiology, regenerative medicine, reproductive medicine, and plant science. Series: "Kyoto Prize Symposium" [Science] [Show ID: 41117]
Azim Surani, Director of Research at the Gurdon Institute and Professor Emeritus at University of Cambridge, received the Kyoto Prize in Basic Sciences, specifically in the field of Life Sciences and Medicine, for his work in demonstrating how male and female mammalian genomes receive distinct imprints during germ cell development. Genomic imprinting introduced a novel concept to Mendelian genetics and is a now fundamental principle in the life sciences. Surani's research has contributed to developmental biology and epigenetics, along with a wide range of life science fields including physiology, regenerative medicine, reproductive medicine, and plant science. Series: "Kyoto Prize Symposium" [Science] [Show ID: 41117]
Azim Surani, Director of Research at the Gurdon Institute and Professor Emeritus at University of Cambridge, received the Kyoto Prize in Basic Sciences, specifically in the field of Life Sciences and Medicine, for his work in demonstrating how male and female mammalian genomes receive distinct imprints during germ cell development. Genomic imprinting introduced a novel concept to Mendelian genetics and is a now fundamental principle in the life sciences. Surani's research has contributed to developmental biology and epigenetics, along with a wide range of life science fields including physiology, regenerative medicine, reproductive medicine, and plant science. Series: "Kyoto Prize Symposium" [Science] [Show ID: 41117]
Azim Surani, Director of Research at the Gurdon Institute and Professor Emeritus at University of Cambridge, received the Kyoto Prize in Basic Sciences, specifically in the field of Life Sciences and Medicine, for his work in demonstrating how male and female mammalian genomes receive distinct imprints during germ cell development. Genomic imprinting introduced a novel concept to Mendelian genetics and is a now fundamental principle in the life sciences. Surani's research has contributed to developmental biology and epigenetics, along with a wide range of life science fields including physiology, regenerative medicine, reproductive medicine, and plant science. Series: "Kyoto Prize Symposium" [Science] [Show ID: 41117]
Welcome to Season 2 of the Orthobullets Podcast.Today's show is Foundations, where we review foundational knowledge for frontline MSK providers such as junior orthopaedic residents, ER physicians, and primary care providers. This episode will cover the topic of Rickets from our Basic Science at Orthobullets.com.Follow Orthobullets on Social Media:FacebookInstagram TwitterLinkedInYouTube
Welcome to Season 2 of the Orthobullets Podcast.Today's show is Foundations, where we review foundational knowledge for frontline MSK providers such as junior orthopaedic residents, ER physicians, and primary care providers. This episode will cover the topic of Articular Cartilage from our Basic Science at Orthobullets.com.Follow Orthobullets on Social Media:FacebookInstagram TwitterLinkedInYouTube
Welcome to Season 2 of the Orthobullets Podcast.In this episode, we review the high-yield topic of Molecular Biology Basics from the Basic Science section.Follow Orthobullets on Social Media:FacebookInstagramTwitterLinkedInYouTube
Episode 2 of ongoing research on Tuberous Sclerosis Complex based on the query~Is CRISPR CAS9 being researched to help/cure tuberous sclerosis?"An exchange with Google AI mode in reference to the above query with the intention of making it clear the trajectory for those with rare diseases in terms of overriding our biological organic template and moving towards a more synthetic version. I picked up where I left off with Episode 1 and talk through Epigenetic "Switches", Gut-Brain Axis and Neuroinflammation, Why Researchers Are Skipping These Links, Potential Reasons for the Research Focus, Funding and Corporate Partnerships, Neuroinflammation Research, The "TAND" Project (TSC-Associated Neuropsychiatric Disorders), The PREVENT Trial, Basic Science and "Somatic Mosaicism", The "Funding Gap" regarding Conflicts of Interest, The Logic of the "Omission", Lived Experience vs. "Proven" Science,Why It Feels "Diabolical" & Finding the "Clean" Data https://www.mdpi.com/1422-0067/22/14/7273 https://pmc.ncbi.nlm.nih.gov/articles/PMC11275973/ https://www.ncbi.nlm.nih.gov/books/NBK206940/ https://www.nature.com/articles/s41398-024-02752-y https://clinicaltrials.gov/study/NCT01289912 https://pmc.ncbi.nlm.nih.gov/articles/PMC9253752/ https://www.intechopen.com/chapters/82669 https://pmc.ncbi.nlm.nih.gov/articles/PMC6748183/ https://pmc.ncbi.nlm.nih.gov/articles/PMC6278824/ https://www.nature.com/articles/s41439-022-00181-1 https://pmc.ncbi.nlm.nih.gov/articles/PMC3035853/ https://pmc.ncbi.nlm.nih.gov/articles/PMC5804531/ https://pubmed.ncbi.nlm.nih.gov/40558831/ https://docs.google.com/document/d/1ncDHvfDHkzVd1-H4Xgulz-mhSZxhwhydK6jWln90L5E/ (contact pjlacy6@gmail.com for access)Become a supporter of this podcast: https://www.spreaker.com/podcast/tsc-talks--1666046/support.
Welcome to Season 2 of the Orthobullets Podcast.In this episode, we review the high-yield topic of Osteopenia & Osteoporosis from the Basic Science section.Follow Orthobullets on Social Media:FacebookInstagramTwitterLinkedInYouTube
In this episode, I continue our rapid review series by examining some HY basic science mechanisms that are commonly tested on the USMLE Step 2CK/3 exams. I also discuss some prognostic factors/disease complications. Audio Download
In this episode, I continue our rapid review series by examining some HY basic science mechanisms that are commonly tested on the USMLE Step 2CK/3 exams. I also discuss some prognostic factors/disease complications. Audio Download
Welcome to Season 2 of the Orthobullets Podcast.In this episode, we review the high-yield topic of Rehab & Prosthetics from the Basic Science section.Follow Orthobullets on Social Media:FacebookInstagramTwitterLinkedInYouTube
In this short podcast, I discuss the upcoming 25 Hour USMLE Step 1 Basic Science Review starting at 5.45 pm EST each day from 2/2-7, 2026 over zoom. The review will be incredibly clinical, focus on integrations, help you understand pathophysiology, and expose you to a large amount of the Step 1 content. This class … Continue reading 25 Hour Step 1 Basic Science Review (Starts Feb 2, 2026)
Welcome to Season 2 of the Orthobullets Podcast.In this episode, we review the high-yield topic of Bone Cells from the Basic Science section.Follow Orthobullets on Social Media:FacebookInstagramTwitterLinkedInYouTube
In this short podcast, I discuss the upcoming 25 Hour USMLE Step 1 Basic Science Review starting at 5.45 pm EST each day from 2/2-7, 2026 over zoom. The review will be incredibly clinical, focus on integrations, help you understand pathophysiology, and expose you to a large amount of the Step 1 content. This class … Continue reading 25 Hour Step 1 Basic Science Review (2/2-7, 2026)
Stem cells hold promise for understanding human disease, screening for novel therapeutics, and regenerating damaged tissues. However, the mechanisms underlying how these cells form and are activated are still being uncovered, and the development of stem cell-derived tissues for drug screening and transplantation is a work in progress. This conversation with leaders in the field explores the fundamentals of stem cell biology, current stem cell-based therapies, and the ethical considerations shaping the future of stem cell research and its clinical applications. Panel Members Lorenz Studer, Director, Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center Sarah E. Millar, Dean for Academic and Scientific Affairs and Chair of the new Department of Stem Cell Biology and Regenerative Medicine, Icahn School of Medicine at Mount Sinai In conversation with Kirsten Sadler Edepli, Professor of Biology, NYUAD; Global Network Professor of Biology, NYU
In this episode, Antonia and Andrew discuss the December 17, 2025 issue of JBJS, along with an added dose of entertainment and pop culture. Listen at the gym, on your commute, or whenever your case is on hold! Link: JBJS website: https://jbjs.org/issue.php Sponsor: This episode is brought to you by JBJS Clinical Classroom. Subspecialties: Trauma, Shoulder, Elbow, Hip, Spine, Basic Science, Orthopaedic Essentials, Pediatrics Chapters (00:00:03) - Your Cases on Hold(00:01:33) - Top of the Pile(00:02:53) - Bizioturmin(00:10:08) - Alcohol and osteoporosis 7,(00:16:27) - Are serum metal levels of concern with dual mobility?(00:22:39) - Polyethylene vs ceramic hips: Do they work?(00:25:13) - Pyrocarbon Hemiarthoplasty for glenohum(00:27:15) - Happy New Year everyone!
Welcome to Season 2 of the Orthobullets Podcast.In this episode, we review the high-yield topic of Gout from the Basic Science section.Follow Orthobullets on Social Media:FacebookInstagramTwitterLinkedInYouTube
In this short podcast, I discuss the upcoming 25 Hour USMLE Step 1 Basic Science Review taking place on zoom from 6-11 pm EST from 12/1-5. The review will be incredibly clinical, focus on integrations, help you understand pathophysiology, and expose you to a large amount of the Step 1 content. This class is also … Continue reading 25 Hour Step 1 Basic Science Review (12/1-5, 2025)
What if you could identify every structural variant in your biologics—without ambiguity, without massive sample requirements, and without the guesswork that plagues traditional mass spectrometry? Cryogenic infrared ion spectroscopy (CIRIS) makes it possible, transforming molecular characterization from frustrating puzzle to precise science.Today's guest, Professor Tom Rizzo, bridges the gap between academic innovation and industrial application. As former Dean of the School of Basic Sciences at EPFL in Lausanne and now Chief Scientific Officer at Isospec Analytics, Tom has spent over two decades developing analytical techniques that solve problems conventional methods can't touch.His journey from a childhood fascination sparked by chemistry demonstrations at the 1964 New York World's Fair to pioneering a breakthrough technology reveals both the persistence required for true innovation and the pathway from laboratory curiosity to commercial reality. For bioprocess scientists struggling with glycan characterization, isomer identification, or any structural puzzle where mass spec alone falls short, this conversation offers both validation and solutions.Episode Highlights:The fundamental limitations of current biomolecular analysis methods and why innovation is critical (02:51)From World's Fair chemistry demos to laser spectroscopy: Tom Rizzo's path to analytical innovation (03:31)The two-decade quest to combine mass spectrometry sensitivity with laser spectroscopy precision—and the machine that finally made it work (04:26)Why Tom transitioned from academic leadership to Isospec Analytics: bringing lab techniques to production environments (09:17)CIRIS fundamentals: how cooling ions to 10 Kelvin unlocks molecular fingerprints that room-temperature methods miss (11:14)CIRIS advantages for biologics: single-ion sensitivity, isomer discrimination, and unique molecular "fingerprints" for definitive identification (14:25)Integrating CIRIS into existing bioprocess workflows: LC-MS compatibility and the path to commercial instrumentation (17:29)Hard-won lessons from translating academic breakthroughs into industrial tools (17:43)When mass spectrometry hits its limits—distinguishing isomers, characterizing glycans, identifying unknowns in complex mixtures—cryogenic infrared ion spectroscopy provides the structural resolution you need. This isn't incremental improvement; it's a fundamental expansion of what's analytically possible.If you're facing molecular identification challenges that conventional methods can't solve, or if you're curious how next-generation analytical techniques will transform bioprocess development, this episode delivers actionable insights from a scientist who's lived both the innovation and implementation journey.Connect with Tom Rizzo:LinkedIn: www.linkedin.com/in/thomas-rizzo-4a0a6314/Contact email: tom@isospec.chIsospec Analytics website: www.isospecanalytics.comNext step:Book a 20-minute call to help you get started on any questions you may have about bioprocessing analytics: https://bruehlmann-consulting.com/call
Called U.S. Public Research Benefits, the database showcases the value of basic science in an easy and accessible format.
In this episode, Antonia and Andrew discuss the November 5, 2025 issue of JBJS, along with an added dose of entertainment and pop culture. Listen at the gym, on your commute, or whenever your case is on hold! Link: JBJS website: https://jbjs.org/issue.php Sponsor: This episode is brought to you by JBJS Clinical Classroom. Subspecialties: Spine, Knee, Hip, Basic Science, Pediatrics, Pain Management, Rehabilitation, Orthopaedic Essentials, Education and Training Chapters (00:00:03) - JBJS: Cases on Hold(00:02:05) - Case on Hold(00:02:53) - This Week's Orthopedic News(00:04:37) - The Broken Wing Sign(00:09:32) - Broken Wing Sign test, sensitivity and specificity(00:14:45) - Does BMI change after total hip and knee arthroplasty?(00:21:48) - Knee and hip replacement: Does this particular study change my practice(00:27:06) - Mayo Clinic orthopedic care: Future of weight loss(00:28:27) - Vitamin C and CRPS after total knee replacement(00:37:40) - Vitamin C pre-cancer screening(00:38:41) - Honorable Mention(00:39:48) - The pelvic inclination angle in congenital cervical scoliosis
Welcome to Season 2 of the Orthobullets Podcast.In this episode, we review the high-yield topic of Genetic Pearls from the Basic Science section.Follow Orthobullets on Social Media:FacebookInstagramTwitterLinkedInYouTube
Welcome to Season 2 of the Orthobullets Podcast.In this episode, we review the high-yield topic of Nonunion and Bone Defects from the Basic Science section.Follow Orthobullets on Social Media:FacebookInstagramTwitterLinkedInYouTube
In this episode, Antonia and Andrew discuss the October 1, 2025 issue of JBJS, along with an added dose of entertainment and pop culture. Listen at the gym, on your commute, or whenever your case is on hold! Link: JBJS website: https://jbjs.org/issue.php Sponsor: This episode is brought to you by JBJS Clinical Classroom. Subspecialties: Knee, Hip, Shoulder, Basic Science, Foot & Ankle, Orthopaedic Essentials Chapters (00:00:03) - Your Cases on Hold, Episode 91(00:01:13) - JBGS: Cases on Hold(00:02:36) - The Top of the Pile(00:03:51) - Predicting ACL Reconstruction Risk with Machine Learning(00:11:09) - Machine Learning vs. SAS in ACL Revision(00:16:46) - Knee Fusions Conver to Total Knee Arthroplasty(00:24:28) - Neuroplasty 1, 8 years follow-up(00:26:30) - Tranexamic acid and absorbable hemostat(00:29:40) - TXA vs Hemostat: Cost vs. Safety(00:35:03) - Immunity and the future of transfusion(00:35:20) - Oxidative Stress and Glycation Stress in Frozen Shoulder(00:38:06) - 4th generation transverse osteotomies for hallux valg
Welcome to Season 2 of the Orthobullets Podcast.In this episode, we review the high-yield topic of Orthopaedic Implants from the Basic Science section.Follow Orthobullets on Social Media:FacebookInstagramTwitterLinkedInYouTube
In this episode, Antonia and Andrew discuss the September 17, 2025 issue of JBJS, along with an added dose of entertainment and pop culture. Listen at the gym, on your commute, or whenever your case is on hold! Link: JBJS website: https://jbjs.org/issue.php Sponsor: This episode is brought to you by JBJS Clinical Classroom. Subspecialties: Knee, Hip, Orthopaedic Essentials, Trauma, Spine, Pediatrics, Basic Science, Foot & Ankle, Rehabilitation, Education & Training, Chapters (00:00:03) - Case is On Hold(00:01:15) - JBJS CME: The 90th Anniversary(00:03:53) - Race and spinal fusion outcomes in a managed healthcare(00:08:43) - Healthcare disparities, access and healthcare segregation(00:14:40) - Clinical Equipoise in Knee Replacement Trials(00:20:48) - The issue of clinician equipoise in Osteo Surgery(00:25:52) - Obesity and postoperative knee arthroplasty outcomes(00:32:59) - The obesity issue in knee surgery(00:38:59) - Slipped capital femoral epiphysis by Navias et al(00:40:39) - Coronal and Sagittal Balance following posterior spinal fusion for adolescent id
Welcome to Season 2 of the Orthobullets Podcast.In this episode, we review the high-yield topic of Bone Grafting from the Basic Science section.Follow Orthobullets on Social Media:FacebookInstagramTwitterLinkedInYouTube
Hello!Today, we have on a promised guest, Jonathan M Berman, an assistant professor in Basic Sciences at New York Institute of Technology, Arkansas, the co-chair of the 2017 March for Science, and the author of a 2020 book called Anti-Vaxxers: How to Challenge a Misinformed Movement. In light of last week's turmoil and spate of resignations and firings at the CDC stemming from changes to vaccine policy, we wanted to invite Jonathan on to talk about the anti-vaccination movement and how it's been turbo-charged by the rise of RFK.Enjoy! This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit goodbye.substack.com/subscribe
On today's episode, Kyle Grieve discusses how mental models from physics, chemistry, and biology can give investors and business leaders sharper decision-making tools. He'll explore how applying these frameworks helps to identify opportunities, avoid risks, and build lasting advantages. IN THIS EPISODE YOU'LL LEARN: 00:00 - Intro 02:06 - How relativity helps investors see opportunities from different perspectives. 07:33 - Why inertia reveals which businesses stay great or stuck over decades. 09:29 - How momentum creates powerful flywheels in business and investing. 23:22 - When leverage accelerates growth or dangerously magnifies risk. 29:13 - How catalysts can rapidly unlock an investing thesis. 35:50 - Why ecosystems multiply value from a single input change. 41:52 - How niche strategies create outsized business advantages. 52:50 - Why honest versus dishonest signals matter for investors. 01:00:19 - How misaligned incentives quietly increase investment risk. Disclaimer: Slight discrepancies in the timestamps may occur due to podcast platform differences. BOOKS AND RESOURCES Join Clay and a select group of passionate value investors for a retreat in Big Sky, Montana. Learn more here. Join the exclusive TIP Mastermind Community to engage in meaningful stock investing discussions with Stig, Clay, Kyle, and the other community members. Buy a copy of The Great Mental Models Part II: Physics, Chemistry and Biology here. Follow Kyle on Twitter and LinkedIn. Check out all the books mentioned and discussed in our podcast episodes here. Enjoy ad-free episodes when you subscribe to our Premium Feed. NEW TO THE SHOW? Get smarter about valuing businesses in just a few minutes each week through our newsletter, The Intrinsic Value Newsletter. Check out our We Study Billionaires Starter Packs. Follow our official social media accounts: X (Twitter) | LinkedIn | Instagram | Facebook | TikTok. Browse through all our episodes (complete with transcripts) here. Try our tool for picking stock winners and managing our portfolios: TIP Finance Tool. Enjoy exclusive perks from our favorite Apps and Services. Learn how to better start, manage, and grow your business with the best business podcasts. SPONSORS Support our free podcast by supporting our sponsors: SimpleMining HardBlock AnchorWatch Human Rights Foundation Vanta Unchained Onramp Netsuite Shopify HELP US OUT! Help us reach new listeners by leaving us a rating and review on Spotify! It takes less than 30 seconds, and really helps our show grow, which allows us to bring on even better guests for you all! Thank you – we really appreciate it! Support our show by becoming a premium member! https://theinvestorspodcastnetwork.supportingcast.fm Support our show by becoming a premium member! https://theinvestorspodcastnetwork.supportingcast.fm Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://theinvestorspodcastnetwork.supportingcast.fm
The NBMEs have become relentless in integrating more and more basic sciences on the USMLE Step 2CK/3 exams. In this podcast, I discuss a large number of basic science concepts that routinely show up on the exam (vignettes, integrations, and contextual information). Audio Download
The NBMEs have become relentless in integrating more and more basic sciences on the USMLE Step 2CK/3 exams. In this podcast, I discuss a large number of basic science concepts that routinely show up on the exam (vignettes, integrations, and contextual information). Audio Download
Our friends at the NBME love to throw in quite a number of basic science topics on the more recent USMLE administrations. In this podcast, I address a number of these topics by using common exam scenarios and making tons of useful integrations. Audio Download
Our friends at the NBME love to throw in quite a number of basic science topics on the more recent USMLE administrations. In this podcast, I address a number of these topics by using common exam scenarios and making tons of useful integrations. Audio Download
Welcome to Season 2 of the Orthobullets Podcast.Today's show is Foundations, where we review foundational knowledge for frontline MSK providers such as junior orthopaedic residents, ER physicians, and primary care providers. This episode will cover the topic of Osteopenia & Osteoporosis, from our Basic Science section at Orthobullets.com.Follow Orthobullets on Social Media:FacebookInstagram TwitterLinkedInYouTube
Welcome to Season 2 of the Orthobullets Podcast.Today's show is Foundations, where we review foundational knowledge for frontline MSK providers such as junior orthopaedic residents, ER physicians, and primary care providers. This episode will cover the topic of Rheumatoid Arthritis, from our Basic Science section at Orthobullets.com.Follow Orthobullets on Social Media:FacebookInstagram TwitterLinkedInYouTube
Welcome to Season 2 of the Orthobullets Podcast.Today's show is Foundations, where we review foundational knowledge for frontline MSK providers such as junior orthopaedic residents, ER physicians, and primary care providers.This episode will cover the topic of Fracture Healing, from our Basic Science section at Orthobullets.com.Follow Orthobullets on Social Media:FacebookInstagram TwitterLinkedInYouTube
Welcome to Season 2 of the Orthobullets Podcast.In this episode, we review the high-yield topic of Opiates & Analgesic Medications from the Basic Science section.Follow Orthobullets on Social Media:FacebookInstagramTwitterLinkedInYouTube
Welcome to Season 2 of the Orthobullets Podcast.In this episode, we review the high-yield topic of Tendons from the Basic Science section.Follow Orthobullets on Social Media:FacebookInstagramTwitterLinkedInYouTube
© 2020-2026 Ivy Podcast Discovery LLC
