Podcasts about Acetylcholine

In this episode I explain how your vagus nerve—an extensive neural pathway linking your brain and body in both directions—powerfully regulates your mood, digestion, alertness and even certain food cravings, and I explain how you can activate certain vagus nerve pathways to improve your heart rate variability (HRV), a key marker of health and longevity. I also explain how to control vagal pathways to enhance your focus and alertness to improve learning and neuroplasticity. And I explain how your vagus nerve controls levels of serotonin in both your gut and brain, impacting your mood and emotional resilience and how to keep that pathway robust. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman LMNT: https://drinklmnt.com/huberman Joovv: https://joovv.com/huberman ROKA: https://roka.com/huberman Function: https://functionhealth.com/huberman Timestamps 00:00:00 Vagus Nerve 00:02:43 Sponsors: LMNT & Joovv 00:05:41 Cranial Nerves, Inputs (Afferents) & Outputs (Efferents), Sensory & Motor 00:12:40 Vagus Nerve & Sensory Pathways, Body & Brain 00:18:30 Sensory Information, Chemical & Mechanical Information 00:23:49 Sympathetic & Parasympathetic Nervous Systems, Vagus Nerve, Tool: Calming & Auricular (Ear) Sensation 00:30:19 Sponsors: AG1 & ROKA 00:33:38 Vagus Nerve Motor Outputs 00:36:00 Autoregulation, Improving Heart Rate Variability (HRV) Tools: HR Deceleration 00:49:46 Aging, Declining HRV, Health, Activity, Tool 00:52:31 Tool: Exercise, Increase Alertness for Cognitive & Physical Activity, Motivation 01:04:26 Sponsor: Function 01:06:14 Adult Neuroplasticity & Learning, Acetylcholine, Alpha GPC Nicotine 01:11:48 Tools: High-Intensity Exercise, Increase Alertness, Focus & Learning; Sleep 01:18:14 Serotonin, Gut, Brain & Mood, Depression & SSRIs 01:21:34 Serotonin, Improve Mood & Gut Health, Irritable Bowel Syndrome (IBS), Tools: Low-Sugar Fermented Foods, Tryptophan 01:28:49 Mood, Depression, Gut Health & Vagal Signaling, Probiotics 01:32:12 Calming Down via Vagus Nerve, Tool: Neck Peri-Arterial Vagus Stretch 01:42:00 Tools: Calming Down, Humming, Extended Exhales 01:46:38 Recap 01:48:46 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

In part two of this two-part series, Dr. Stacey Clardy and Dr. Elia Sechi discuss how to approach the management of patients in clinic when there is concern for a possible false positive on the radioimmunoprecipitation assay for the acetylcholine receptor antibody. Show reference: https://www.neurology.org/doi/10.1212/WNL.0000000000213498 

In part one of this two-part series, Dr. Stacey Clardy and Dr. Elia Sechi discuss the clinical scenarios where the commonly used assay for myasthenia gravis is most likely to produce false positive results in patients who do not actually have myasthenia gravis. Show reference: https://www.neurology.org/doi/10.1212/WNL.0000000000213498  

Dr. Stacey Clardy talks with Dr. Elia Sechi about the importance of understanding lab test results, the performance characteristics of assays, and the real-world implications of false positives in myasthenia gravis testing. Read the related article in Neurology®. Disclosures can be found at Neurology.org. 

In this episode, we detail the role of vitamin B1 (thiamine) in supporting gastrointestinal function, highlighting intestinal motility through vitamin B1's involvement in acetyl-CoA and acetylcholine synthesis. We discuss thiamine insufficiency as well as how small intestinal bacterial overgrowth (SIBO) can further affect thiamine availability. We further detail host defense mechanisms—including gastric acid, pancreatic enzymes, and gastrointestinal motility—that work in concert to regulate microbial balance in the small intestine.Topics: 1. Introduction- Focus on SIBO, intestinal motility, and vitamin B1 (thiamine)  2. Small Intestine and Microbial Regulation- Low bacterial load under healthy conditions  - Protective mechanisms: gastric acid, enzymes, motility…   3. Overview of SIBO Subtypes - H₂-SIBO, hydrogen-producing bacteria  - IMO, methane-producing archaea  - H₂S-SIBO, hydrogen sulfide-producing bacteria  - Subtypes can coexist, share underlying factors   4. Host Factors in Microbial Regulation - Gastric acid, motility, pancreatic enzymes, bile acids, and immune surveillance  5. Gastric Acid and Parietal Cells  - Hydrochloric acid and intrinsic factor  - Acid environment supports digestion and microbial regulation  - Protein denaturation and pepsin activation 6. Chief Cells and Enzyme Function - Pepsinogen and gastric lipase  - Pepsinogen activated by acidic pH   7. Hypochlorhydria and Downstream Effects 8. Pancreatic Enzymes in the Small Intestine   9. Intestinal Motility and the Enteric Nervous System (ENS)- Coordinated smooth muscle contractions  - Myenteric and submucosal plexuses   10. Intestinal Wall Anatomy - Epithelium and lamina propria - Submucosa contains the submucosal plexus  - Myenteric plexus located between muscle layers   11. Vitamin B1 (Thiamine) and Gastrointestinal Function  - Acetylcholine synthesized from choline and acetyl-CoA  - Acetyl-CoA formation, thiamine availability  - Acetylcholine signaling  12. SIBO and Nutrient Availability- Bacterial overgrowth can affect nutrient absorption  - Thiaminases   13. Conclusion  - Root cause approach, multi-factorial Thanks for tuning in!Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Follow Chloe on TikTok @chloe_c_porterVisit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more!

In this episode, we dive into the early therapies and how our understanding of vascular physiology drastically changed the management of pulmonary hypertension. Intro 0:12 In this episode 0:18 Recap of part 1 & 2 0:31 What part 3 is about 2:31 WHO conference in 1975: Treating pulmonary hypertension 3:48 The Discovery of Non-Steroidal Anti-inflammatory Drugs (NSAIDs), Part 1 5:20 Epoprostenol 6:18 Prostacyclin 10:37 Endothelin antagonists 11:41 Phosphodiesterase type 5 (PDE5) inhibitors 14:08 Interaction of nerves and blood vessels 15:06 The Soups VS the Sparks 17:36 A dreamed experiment 19:06 Acetylcholine 23:23  Enter “the calabar bean” 24:45 Acetylcholine and vasodilation: 1976 26:01 Rabbit aorta 27:45 Nitric oxide 29:38 Why are we using nitric oxide to treat pulmonary hypertension? 31:31 Tachyphylaxis 33:48 TNT factories 35:09 Nitrous oxide and tachyphylaxis 36:52 Pfizer in the 1980s 38:06 Understanding the trigger of pulmonary hypertension 40:53 PDE5 and nitric oxide and pulmonary hypertension 43:07 The end of the ripping yarns 44:20 Coming up in part 4 46:17 Thanks for listening 47:29 We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum. References: Bernard C. C R Soc Biol. 1851;3:163-164. Furchgott RF, et al. Nature. 1980;doi:10.1038/288373a0. Galiè N, et al. N Engl J Med. 2005;doi:10.1056/NEJMoa050010. Ghofrani HA, et al. Nat Rev Drug Discov. 2006;doi:10.1038/nrd2030. Giordano D, et al. Biochim Biophys Acta. 2001;doi:10.1016/s0167-4889(01)00086-6. Guthrie F. Q J Chem Soc. 1859;doi:10.1039/QJ8591100245. Higenbottam T, et al. Lancet. 1984;doi:10.1016/s0140-6736(84)91452-1. Marsh N, et al. Clin Exp Pharmacol Physiol. 2000;doi:10.1046/j.1440-1681.2000.03240.x. Montastruc JL, et al. Clin Auton Res. 1996;doi:10.1007/BF02281906. Nejad SH, et al. Future Cardiol. 2024;doi:10.1080/14796678.2024.2367390. Tansey EM. C R Biol. 2006;doi:10.10116/j.crvi.2006.03.012. Warren JV. Trans Am Clin Climatol Assoc. 1988;99:10-6. Disclosures: Brown reports no relevant financial disclosures.

Show notes: (0:49) Dr. Stasha Gominak and the RightSleep program (6:03) The role of gut microbiome and vitamin deficiencies in sleep disorders (12:35) Importance of vitamin D and optimal levels for sleep health (22:30) How B vitamins impact sleep and overall well-being (32:00) Acetylcholine's role in sleep and inflammation (41:00) Overview of the Right Sleep program and how it works (46:00) Understanding B vitamin supplementation and dosage (56:42) Where to find Dr. Gominak's resources and closing thoughts (57:59) Outro   Who is Dr. Stasha Gominak?   Dr. Gominak attended college in California and medical school at Baylor College of Medicine in Houston, receiving her MD degree in 1983. She completed a Neurology residency in 1989 at the Harvard affiliated, Massachusetts General Hospital in Boston. From 1991-2004 she practiced as a general neurologist in the San Francisco Bay area.   In 2004 Dr. Gominak moved with her husband to Tyler, Texas, and began to concentrate on treating neurological illness by improving sleep. She published a pivotal article in 2012 proposing that the global struggle with worsening sleep was linked to reduced sun exposure.   In 2016 she followed with a second article linking the change in the intestinal microbiome to the epidemic of poor sleep and described a simple process for normalizing sleep and the intestinal bacterial population, called RightSleep®.    In 2016 she retired from neurology practice to have more time to teach. She currently divides her time between helping individuals, through virtual coaching sessions and teaching clinicians and coaches how to use RightSleep concepts to improve their patients' health and well being. Connect with Dr. Gominak Website: https://drgominak.com/ Links and Resources: Peak Performance Life Peak Performance on Facebook Peak Performance on Instagram  

Carolyn McMakin, MA, DC - frequencyspecific.com Kim Pittis, LCSP, (PHYS), MT - fsmsports365.com   00:14 Patient Case: Rare Condition from Hawaii 01:15 Explaining Medical Terminology 03:35 Detailed Patient History and Treatment 06:59 Videotaping the Treatment Process 10:59 Vestibular Injury and Demonstration 13:45 Visceral Scarring and Treatment Techniques 22:01 Crohn's Disease and Autoimmune Discussion 25:21 Parasites and Crohn's Disease Connection 27:36 Atrial Fibrillation and Vagus Nerve Treatment 30:22 The Vagus Nerve and Its Impact 31:20 Patient Case Study: Neck and Vagus Nerve 32:35 Custom Care and Scar Tissue 34:00 Acetylcholine and Supplements 36:16 Visceral Treatment Techniques 45:24 Parasites and Treatment Options 50:17 Atrial Fibrillation and Scar Tissue 53:10 Insulin Pumps and FSM   Welcome to our deep dive into a unique and complex case study, which was discussed in a recent podcast episode featuring a detailed examination of sclerosing mesenteritis and the role of the vagus nerve in treatment. This post will provide key insights that medical practitioners can apply to their own practice, focusing on understanding the intricate relationships between conditions and how Frequency Specific Microcurrent (FSM) might be leveraged in treatment protocols. Understanding Sclerosing Mesenteritis A patient case was presented involving a condition known as sclerosing mesenteritis. This rare inflammatory disease affects the mesentery, the connective tissue that supports the intestines. In this case, the patient, with a history of Crohn's disease, also developed complications such as atrial fibrillation and dysphonia after receiving a COVID-19 vaccine and subsequently contracting COVID-19 multiple times. Medical Interpretation for Sclerosing Mesenteritis When dealing with the mesentery, it is crucial to understand that it is part of the peritoneal sac encompassing the abdomen's organs. The condition described as "sclerosing" refers to the scarring within this connective tissue. For effective management of this scar tissue, practitioners can focus on identifying affected areas using gentle palpation techniques and specific vocabulary translation for laypeople. The Vagus Nerve and Its Role in Treatment Dr. Carol, in the podcast, highlighted treating a spectrum of symptoms by focusing on the vagus nerve. This nerve influences many systems, including the heart's electrical conductivity, digestive health, and even the body's response to inflammation. In patients with autoimmune conditions, like Crohn's disease, enhancing vagal tone may reduce unnecessary immune responses and inflammation. Practical FSM Applications Medical practitioners should note the efficacy of FSM in managing scar tissue and enhancing autonomic regulation through the vagus. In this case study, strategies included: - Running concussion and vagal tone frequencies to relax tense connective tissues and potentially diminish dysphonia. - Addressing the multifaceted aspects of scar formation by working with frequencies that target sclerosis and inflammation in different tissue types. - Suggesting Huperzine-A supplementation to support neurotransmitter activity affected by vagus dysfunction. Techniques in Palpation and Videography A significant practical learning point from the episode is the technique for hands-on treatment of abdominal adhesions. Practitioners were urged to use flat fingers, apply enough pressure to feel under the layers of scarring, and push gently only when the tissue softens. Documenting these techniques through videography can serve as an educational tool for both practitioners and students. Addressing Parasites and Autoimmune Consequences In cases where autoimmune diseases like Crohn's are suspected to be linked to parasitic infections, practitioners may find it beneficial to employ anti-parasitic drug protocols alongside FSM treatments to address the root causes of inflammation.  Key Takeaways for Practitioners: 1. Pay attention to comprehensive treatment plans that involve both conventional and complementary approaches like FSM. 2. Understand the anatomy involved and leverage FSM to target specific tissues effectively. 3. Consider adjunct supplements and medication for holistic treatment, especially in autoimmune conditions. 4. Continually educate and update techniques through resources such as videography and peer consultation. As shown in this podcast, exploring the intricacies of conditions like sclerosing mesenteritis through the lens of vagus nerve treatment opens new avenues for holistic patient care. Such insights not only enrich practitioner knowledge but also enhance the effectiveness of patient outcomes.

Acetylcholine enhances memory, focus, and muscle function, earning its reputation as a natural nootropic. But, as we age, the body's ability to produce it declines, potentially impacting brain health and physical performance. Listen in this week as Dee explains how acetylcholine is made in the body, and practical ways to boost its production through diet and supplementation. Reference:Nakazaki, E., Mah, E., Sanoshy, K., Citrolo, D., & Watanabe, F. (2021). Citicoline and memory function in healthy older adults: A randomized, double-blind, placebo-controlled clinical trial. Journal of Nutrition, 151(8), 2153–2160. https://www.sciencedirect.com/science/article/pii/S002231662200267X?via%3DihubLink to purchase choline supplement: https://amzn.to/40Mmg6c

In this episode, we explore some of the neural and cellular mechanisms underlying gastrointestinal motility, emphasizing the roles of the enteric nervous system (ENS) and interstitial cells of Cajal (ICCs) in coordinating smooth muscle contractions throughout the digestive tract. We detail disruptions in motility seen in dysautonomia, intestinal methanogen overgrowth (IMO), and small intestinal bacterial overgrowth (SIBO). And, we finish with a brief discussion on the impacts of low stomach acid. Topics: 1. Introduction to Gastrointestinal Motility - Coordinated contractions of smooth muscle that move food, liquid, and waste through the gastrointestinal (GI) tract. - Neural, hormonal, and microbial factors. - Intestinal methanogen overgrowth (IMO) and small intestinal bacterial overgrowth (SIBO). 2. Neural Regulation of Gut Motility - The enteric nervous system (ENS) embedded in the walls of the GI tract. - The ENS, central nervous system (CNS), and vagus nerve. - The myenteric plexus governs motor control and peristalsis, while the submucosal plexus regulates secretion, absorption, and blood flow. - Stress and motility 3. Cellular Regulation of Gut Motility - Interstitial cells of Cajal (ICCs), pacemaker cells located near smooth muscle cells. - ICCs generate slow-wave electrical activity. - Acetylcholine enhances smooth muscle contraction. 4. Dysmotility and Potential Contributing Factors - Impaired ICC function, smooth muscle dysfunction, nervous system dysfunction. - Dysautonomia, a dysfunction of the autonomic nervous system. - External stressors, hormonal imbalances, and more. 5. Intestinal Methanogen Overgrowth (IMO) - Characterized by an overgrowth of methane-producing archaea in the intestines. - Excess methane production affects smooth muscle activity and can slow intestinal transit. - Symptoms such as bloating, abdominal discomfort, constipation. - Breath testing. 6. Small Intestinal Bacterial Overgrowth (SIBO) - Excessive bacterial colonization in the small intestine, disrupting normal gut function. - Protective mechanisms including stomach acid and intestinal motility. - Low stomach acid (hypochlorhydria) reduces the acidic environment needed to inhibit bacterial colonization. - Bloating, diarrhea/constipation, and more. 7. Overlap Between IMO and SIBO - Excess hydrogen produced in SIBO can serve as a substrate for methane production in IMO. - Can exacerbate each other, creating a loop that worsens symptoms. 8. Addressing Dysmotility and Overgrowth - Determining the root cause of dysmotility. - Dysmotility can involve multiple regions of the GI tract. Thank you to our episode sponsors: 1. Shop Fresh Press Farms' Peach Cider Vinegar at Sprouts locations nationwide, and check out their full collection here. 2. Check out ⁠⁠⁠⁠Ulyana Organics'⁠⁠⁠⁠ ⁠⁠⁠⁠Tallow Wild Yam Cream⁠⁠⁠⁠ and ⁠⁠⁠⁠Healing Facial Oil⁠⁠⁠⁠, and use code ⁠⁠⁠⁠CHLOE10⁠⁠⁠⁠ 10% off your order. Thanks for tuning in! Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more!

In this Huberman Lab Essentials episode, I explain how neuroplasticity allows the brain to continue to adapt and change throughout life, particularly through focused attention and active engagement in learning. I explain how neuroplasticity differs in children and adults, highlighting the key neurochemicals required for adult learning. I explain science-supported protocols to boost alertness and improve attention, including techniques like visual focus and goal accountability. I also discuss how sleep, along with practices such as non-sleep deep rest (NSDR) and naps, support the brain to enhance learning.  Huberman Lab Essentials are short episodes (approximately 30 minutes) focused on essential science and protocol takeaways from past Huberman Lab episodes. Essentials will be released every Thursday, and our full-length episodes will still be released every Monday. Read the full show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman David: https://davidprotein.com/huberman LMNT: https://drinklmnt.com/huberman More Huberman Lab Huberman Lab Premium: https://go.hubermanlab.com/premium Huberman Lab Merch: https://go.hubermanlab.com/merch Timestamps 00:00:00 Huberman Lab Essentials; Neuroplasticity 00:03:27 Sponsor: David 00:04:43 New Neurons; Sensory Information, Brain & Customized Map 00:07:40 Recognition, Awareness of Behaviors 00:09:58 Sponsor: AG1 00:11:06 Attention & Neuroplasticity 00:15:40 Epinephrine, Acetylcholine & Nervous System Change 00:18:20 Improve Alertness, Epinephrine, Tool: Accountability  00:20:39 Improve Attention, Acetylcholine, Nicotine 00:23:09 Sponsor: LMNT 00:24:26 Tool: Visual Focus & Mental Focus 00:29:54 Tool: Ultradian Cycles, Anchoring Attention 00:31:00 Sleep & Neuroplasticity; NSDR, Naps 00:33:34 Recap & Key Takeaways 00:36:38 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Recommendations, Sponsors Disclaimer & Disclosures

Drs. Luan D. Truong, Richard J. Johnson, and Gabriela Espinosa Garcia discuss the findings from their study, "Production of Acetylcholine by Podocytes and its Protection from Kidney Injury in Glomerulonephritis," with JASN Deputy Editor Alessia Fornoni.

Yes!!! Mijn lievelingsneurotransmitter: Acetylcholine

Wellness + Wisdom | Episode 660 What are the best tools to optimize your brain and body? Mark Effinger, Biochemist and Founder of Nootopia, joins Josh Trent on the Wellness + Wisdom podcast, special replay of episode 593, to discuss the powerful positive effects nootropics have on the human brain and body, how to balance Acetylcholine levels, why you need dopamine and drive to obtain best possible results, and the benefits of taking GABA and glutamate supplements. "The way that nootropics work is they affect neurochemicals that are available in your gut: serotonin, adrenaline, norepinephrine, and dopamine. They activate certain neurochemical processes in the brain and they also provide the raw products so that your brain can create the neurochemicals necessary. They also support neurogenesis which is the blooming and creation of new neurons." - Mark Effinger 10% Off Nootopia UNLOCK YOUR BRAIN'S Maximum Focus, Concentration + Creativity 10% off with code "JOSH10" Try Josh‘s favorite Nootopia product: Zamner Juice! “Zamner” Means “Going Beyond the Beyond.” • Designed to Sustainably Stimulate Dopamine, Serotonin, and GABA Production • Essential Neurotransmitters for a Positive Mood • Feel Almost Immediate Raise of Mental Well-Being and Outright Euphoria • Be More Outgoing, Confident, and Better with Words in Social Situations • Powerful at Boosting Good Mood Save 10% off of your Zamner Juice order with "JOSH10" In This Episode, Mark Effinger Uncovers: [01:30] Allow Hardship to Empower You Mark Effinger Nootopia - 10% off with code: "JOSH10" 497 Mark Effinger | Brain + Mood Optimization: Become Unstoppable With Nootropics The benefits of nootropic supplements. The story of Mark‘s wife committing suicide. How seeing the depth of addiction changes your perspective on life. What motivated Mark to start creating prototypes for supplements. [10:10] The Power of Nootropics Mark‘s journey of developing the first supplement. How the first prototype caused a cognitive load. Unpacking how nootropics work in the human body. How nootropics support neurogenesis. Why improving liver function can help prevent Alzheimer‘s. [13:35] How to Improve Your Cognition How nootropics help Josh stay focused and avoid distractions. Nootropics as Cognitive Enhancers: Types, Dosage and Side Effects of Smart Drugs How nootropics increase mitochondrial activity. Why some Nootopia products contain ketones. [16:10] Achieve Cognitive + Spiritual Surplus Collagenius - 10% off with code "JOSH10" Why we need to take care of our physiology before anything else. We are not able to navigate different phases of our relationships. The importance of having a purpose in life. Why most people lack cognitive and spiritual surplus. [22:30] Life-Changing Events + Decisions Why Mark felt burnt out and what changed his life. How his body expelled Accutane from the muscle fiber and fascia. Elon Musk Why we need to learn to master task switching. My First Million Podcast [29:00] Neurotransmitters The Top 5 Neurotransmitters from a Clinical Neurologist's Perspective Charlie Rose Unpacking how Nootopia labs function. The lack of Acetylcholine causes problems with speech. Why Mark has a strong connection to music and movies. [35:50] How to Balance Acetylcholine Levels What happens when we have too much Acetylcholine in the body. How to keep the flow of Acetylcholine steady. Josh‘s favorite Nootopia products. Why carbon dioxide spending is the measurement of athlete‘s performance. The reason why we need to remove carbon dioxide and oxidized fats from the body. [43:40] Dopamine + Drive for Achieving Good Results Bryan Johnson How we become dependent on dopamine to feel accomplished. Clean Fifteen How we can find joy in doing the right thing instead of following our unhealthy drive. Why dopamine can be both good and bad. [51:00] Embrace The Pain of Getting to Your Goal The benefits of cold plunging. How Nootopia‘s Dopa Drops are designed for a three-stage dopamine release. The importance of enjoying the pain of the process to getting to the reward. David Goggins How we can become limitless with Nootopia. Unpacking how to avoid the spike and drop of dopamine. How weightlifters deplete themselves of dopamine. [01:02:40] GABA + Glutamate Neurotransmitters How glutamate wakes you up and makes you hypervigilant. Why Mark was motivated by helping people with addiction to create a revolutionary product. How glutamate removes the delay between thought and action. Why diet causes low or high glutamate levels. The benefits of GABA for down-regulation of the nervous system and making decisions under stress. [01:11:20] How to Avoid SSRI Mood Swings How to recognize what we need to optimize for. The tools for health optimization. Why serotonin is not the "happy" molecule. How selective serotonin recycles the re-uptake cycle. Maria Bamford How to avoid mood swings with SSRI. [01:16:15] Recover from Addiction with Nootropics How bipolar medications prevent Josh‘s mom from feeling the highs and lows. Why Mark wants everyone to have access to biological optimization. In Nootopia, people get a neurochemical analysis to understand where they‘re dominant and what they‘re lacking. Why nootropics are anti-addictive. Addiction is a byproduct of neurochemical processes and repeated systems. [01:27:55] Biomarkers of Aging Why pharmaceutical drugs are not a long-term solution to addiction. The difference between plant-derived and lab-grown nootropics. The peptides Mark is currently researching. David Sinclair How to modulate hormones to prevent aging and disease. Why detoxication gets less efficient as we get older. [01:39:55] The Essence of Nootopia How Nootopia collaborates with scientists to deliver the best products. The reason why Mark and his team meditate in their meetings. Where Nootopia sources their ingredients. The Last of Us [01:48:20] Zamner Juice: A Solution for Entrepreneurs How Zamner Juice increases verbal fluency. 482 Dave Asprey | Advanced Biohacking For Body Mind & Spirit: How To Train A Healthy Brain, Boost Your Flow State + Remove False Beliefs The science of processing cordyceps. Why they‘re searching for a solution to the oil crisis. The Ultimate Nutrition Bible: Easily Create the Perfect Diet that Fits Your Lifestyle, Goals, and Genetics by Matt Gallant and Wade Lightheart Leave Wellness + Wisdom a Review on Apple Podcasts

Want longer episodes that cover all things human body and medicine?Join us on our other podcast!Apple PodcastSpotifyYouTube Hosted on Acast. See acast.com/privacy for more information.

Replying to a question on whether or not Choline is good or bad to take? The answer in this episode details 3 positive and 3 possible negative side effects of Choline. Disclaimer: This video is strictly for educational purposes. It is not a substitute for seeking professional medical help. Interested in SMB Pre-Workout? Head over to https://smb-nutrition.myshopify.com/ Have Questions/ Comments? I can answer them in an upcoming episode. Instagram: https://www.instagram.com/howardsblend/ TikTok https://www.tiktok.com/@smbnutrition Send me an email smbsupps@gmail.com Resources: https://www.ncbi.nlm.nih.gov/books/NBK557825/ https://www.ncbi.nlm.nih.gov/books/NBK11143/#:~:text=Acetylcholine%20is%20synthesized%20in%20nerve,as%20one%20of%20its%20transmitters. https://lpi.oregonstate.edu/mic/other-nutrients/choline#:~:text=Major%20source%20of%20methyl%20groups&text=In%20the%20mitochondrial%20inner%20membrane,or%20the%20cytosol%20(2). https://molmed.biomedcentral.com/articles/10.1186/s10020-021-00380-6 https://www.ncbi.nlm.nih.gov/books/NBK555909/ https://www.ncbi.nlm.nih.gov/books/NBK459227/ https://www.translationalres.com/article/S1931-5244(20)30203-6/fulltext https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865740/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992803/ Image Resources: https://www.researchgate.net/figure/Chemical-structure-of-choline-phosphocholine-sn-glycero-3-phosphocholine-and_fig2_275472542 https://www.mayoclinic.org/diseases-conditions/hyperhidrosis/multimedia/sweat-glands/img-20007980

In Part 2 of the Excitation and Inhibition phenomena, we discuss Metabolic "bank" account and demands of navigating the social world. We discuss if we have enough resources or if we will run a metabolic deficits (think burnout and avoidance, and social isolation). We cover NMDA and AMPA and different Autistic Phenotypes. In addition, we review Neuromodulators, which are vast in our biology and determine how and where to direct our attention and energy. Lastly, we discuss the medial Prefrontal Cortex and how it integrates the "self" with the outside world.Don't try to change an Autistic person because they are different than you or different than others. Don't let that offend your beliefs and capacity to apply critical thinking in life.https://www.nature.com/articles/s41398-023-02317-5https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723386/https://www.nature.com/articles/s41398-018-0155-1https://www.nature.com/articles/nature10360https://onlinelibrary.wiley.com/doi/full/10.1034/j.1601-183X.2003.00037.x?sid=nlm%3Apubmedhttps://www.nature.com/articles/s41380-022-01506-w(0:00) Introduction; Know Autism and Make Informed Decisions; Biological Aspects influencing Excitation / Inhibition Phenomena(4:30) Metabolic "Bank" Account and Resources; E/I creates criteria A and B; NMDA and AMPA, and more on the Striatum(10:02) Neuromodulators- Serotonin, Dopamine, Epinephrine and Norepinephrine, Acetylcholine; Active versus Passive Coping; Activating Systems and Cells and influencing Learning and Memory (Neuroplasticity); Nicotinic Receptors and Rapid-Excitation(15:20) medial Prefrontal Cortex (mPFC)- Metabolic demands and planning while considering Feelings, Integrating the Self and the Outside World; How E/I interacts; a brief explanation on Default Mode Network; Quieting the Body, or not; Information-Processing; Thalamocortical(20:19) Pursuits and Preference- Wanting and Having and being Autistic is fine, and others need to accept our phenotypes; sensory-input causes Faster Firing Rates in normal E/I- Image an imbalanced E/I(22:25) Wrap-up and understanding Autism, and Contact Info

This is episode 2 of a 6-part special series on sleep with Dr. Matthew Walker, Ph.D., a professor of neuroscience and psychology and founder of the Center for Human Sleep Science at the University of California, Berkeley. We discuss basic and advanced tools for improving sleep and explain how sleep quality is affected by temperature, light and dark, caffeine, alcohol, cannabis, nutrition, meal timing, and different medications.  Dr. Walker also provides strategies for coping with a poor night of sleep, wind-down routines, technology in the bedroom, insomnia, visualizations, and building sleep “confidence.”  We also discuss the current status of sleep research for developing advanced techniques to optimize sleep.  This episode provides numerous zero-cost behavioral protocols for improving sleep quality and restorative power, which can benefit daytime mood, energy, performance, and overall health.  The next episode in this special series explores napping, caffeine, and additional protocols to improve sleep. For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Helix Sleep: https://helixsleep.com/huberman WHOOP: https://join.whoop.com/huberman Waking Up: https://wakingup.com/huberman InsideTracker: https://insidetracker.com/huberman Momentous: https://livemomentous.com/huberman Timestamps (00:00:00) Improving Sleep (00:01:16) Sponsors: Helix Sleep, WHOOP & Waking Up (00:05:30) Basics of Sleep Hygiene, Regularity, Dark & Light (00:12:05) Light, Day & Night; Cortisol, Insomnia (00:18:45) Temperature; “Walk It Out”; Alcohol & Caffeine (00:26:05) Sleep Association, Bed vs. Sofa (00:29:43) Tool: Falling Asleep; Meditation, Breathing (00:35:23) Sponsor: AG1 (00:36:37) Alcohol & Sleep Disruption (00:40:01) Food & Sleep, Carbs, Melatonin (00:49:25) Caffeine; Afternoon Coffee, Nighttime Waking (00:55:52) Caffeine Metabolism & Sleep, Individual Variation (01:01:19) Sponsor: InsideTracker (01:02:04) Cannabis: THC vs. CBD, REM Sleep, Withdrawal (01:12:03) Sleep Hygiene Basics (01:16:08) Tool: Poor Sleep Compensation, “Do Nothing” (01:20:23) Tool: Sleep Deprivation & Exercise (01:24:11) Insomnia Intervention & Bedtime Rescheduling, Sleep Confidence (01:32:58) Wind-Down Routine; Mental Walk; Clocks & Phones (01:41:29) Advanced Sleep Optimization, Electric Manipulation (01:50:07) Temperature Manipulation, Elderly, Insomnia (01:58:57) Tool: Warm Bath Effect & Sleep, Sauna (02:04:36) Acoustic Stimulation, White Noise, Pink Noise (02:13:30) Rocking & Sleep, Body Position (02:24:17) Enhance REM Sleep & Temperature; Sleep Medications (02:28:35) Pharmacology, DORAs & REM Sleep; Narcolepsy & Insomnia (02:34:12) Acetylcholine, Serotonin, Peptides; Balance (02:40:45) Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Momentous, Social Media, Neural Network Newsletter Disclaimer

Discover the secrets to optimal brain health and cognition with leading expert Dr. Gregory Kelly. From the importance of sleep and body clocks to the role of nootropics in enhancing cognitive skills, this podcast provides insights and advice for a sharper mind. 0:02:01 The importance of body clocks, sleep, and cognition 0:04:48 The impact of deep sleep on toxin release 0:06:46 Sleep's impact on focus, productivity, and achieving flow 0:09:23 Personal experience with napping and nootropics 0:10:25 Definition of nootropics and their role in cognitive skills 0:12:27 Acetylcholine's importance for attention and memory 0:17:00 Extensive research in formulating Neurohacker Collective products 0:23:12 The role of adaptogens in normalizing brain function 0:27:00 Attention restoration breaks are important for optimal cognitive function 0:29:41 L-thenine and phenine can enhance focus and relaxation

I call it the "Tesla" of acetylcholine precursors because it's not cheap and, while it certainly enables cognitive horsepower for peak performance for some, it's far from the most reliable smart drug. I did try taking it alongside a downloadable Piracetam infoceutical and the resulting cognitive performance enhancement left my socks less than blown off. However, the 4.4 Dual N-back brain training score I achieved on Alpha GPC was one of my best, confirming that it is a quintessential cognition-enhancing smart drug.Since 2015 there have been nearly 180 items of human research published in scientific journals, including 10 clinical trials. Let's delve into some of the recent research on Alpha GPC...Read review

Wellness + Wisdom | Episode 593 What are the best tools to optimize your brain and body? Mark Effinger, Biochemist and Founder of Nootopia, joins Josh Trent on the Wellness + Wisdom podcast, episode 593, to discuss the powerful positive effects nootropics have on the human brain and body, how to balance Acetylcholine levels, why you need dopamine and drive to obtain best possible results, and the benefits of taking GABA and glutamate supplements. "The way that nootropics work is they affect neurochemicals that are available in your gut: serotonin, adrenaline, norepinephrine, and dopamine. They activate certain neurochemical processes in the brain and they also provide the raw products so that your brain can create the neurochemicals necessary. They also support neurogenesis which is the blooming and creation of new neurons." - Mark Effinger 10% Off Nootopia UNLOCK YOUR BRAIN'S Maximum Focus, Concentration + Creativity 10% off with code "JOSH10" Try Josh‘s favorite Nootopia product: Zamner Juice! “Zamner” Means “Going Beyond the Beyond.” • Designed to Sustainably Stimulate Dopamine, Serotonin, and GABA Production • Essential Neurotransmitters for a Positive Mood • Feel Almost Immediate Raise of Mental Well-Being and Outright Euphoria • Be More Outgoing, Confident, and Better with Words in Social Situations • Powerful at Boosting Good Mood Save 10% off of your Zamner Juice order with "JOSH10" In This Episode, Mark Effinger Uncovers: [01:30] Allow Hardship to Empower You Mark Effinger Nootopia - 10% off with code: "JOSH10" 497 Mark Effinger | Brain + Mood Optimization: Become Unstoppable With Nootropics The benefits of nootropic supplements. The story of Mark‘s wife committing suicide. How seeing the depth of addiction changes your perspective on life. What motivated Mark to start creating prototypes for supplements. [10:10] The Power of Nootropics Mark‘s journey of developing the first supplement. How the first prototype caused a cognitive load. Unpacking how nootropics work in the human body. How nootropics support neurogenesis. Why improving liver function can help prevent Alzheimer‘s. [13:35] How to Improve Your Cognition How nootropics help Josh stay focused and avoid distractions. Nootropics as Cognitive Enhancers: Types, Dosage and Side Effects of Smart Drugs How nootropics increase mitochondrial activity. Why some Nootopia products contain ketones. [16:10] Achieve Cognitive + Spiritual Surplus Collagenius - 10% off with code "JOSH10" Why we need to take care of our physiology before anything else. We are not able to navigate different phases of our relationships. The importance of having a purpose in life. Why most people lack cognitive and spiritual surplus. [22:30] Life-Changing Events + Decisions Why Mark felt burnt out and what changed his life. How his body expelled Accutane from the muscle fiber and fascia. Elon Musk Why we need to learn to master task switching. My First Million Podcast [29:00] Neurotransmitters The Top 5 Neurotransmitters from a Clinical Neurologist's Perspective Charlie Rose Unpacking how Nootopia labs function. The lack of Acetylcholine causes problems with speech. Why Mark has a strong connection to music and movies. [35:50] How to Balance Acetylcholine Levels What happens when we have too much Acetylcholine in the body. How to keep the flow of Acetylcholine steady. Josh‘s favorite Nootopia products. Why carbon dioxide spending is the measurement of athlete‘s performance. The reason why we need to remove carbon dioxide and oxidized fats from the body. [43:40] Dopamine + Drive for Achieving Good Results Bryan Johnson How we become dependent on dopamine to feel accomplished. Clean Fifteen How we can find joy in doing the right thing instead of following our unhealthy drive. Why dopamine can be both good and bad. [51:00] Embrace The Pain of Getting to Your Goal The benefits of cold plunging. How Nootopia‘s Dopa Drops are designed for a three-stage dopamine release. The importance of enjoying the pain of the process to getting to the reward. David Goggins How we can become limitless with Nootopia. Unpacking how to avoid the spike and drop of dopamine. How weightlifters deplete themselves of dopamine. [01:02:40] GABA + Glutamate Neurotransmitters How glutamate wakes you up and makes you hypervigilant. Why Mark was motivated by helping people with addiction to create a revolutionary product. How glutamate removes the delay between thought and action. Why diet causes low or high glutamate levels. The benefits of GABA for down-regulation of the nervous system and making decisions under stress. [01:11:20] How to Avoid SSRI Mood Swings How to recognize what we need to optimize for. The tools for health optimization. Why serotonin is not the "happy" molecule. How selective serotonin recycles the re-uptake cycle. Maria Bamford How to avoid mood swings with SSRI. [01:16:15] Recover from Addiction with Nootropics How bipolar medications prevent Josh‘s mom from feeling the highs and lows. Why Mark wants everyone to have access to biological optimization. In Nootopia, people get a neurochemical analysis to understand where they‘re dominant and what they‘re lacking. Why nootropics are anti-addictive. Addiction is a byproduct of neurochemical processes and repeated systems. [01:27:55] Biomarkers of Aging Why pharmaceutical drugs are not a long-term solution to addiction. The difference between plant-derived and lab-grown nootropics. The peptides Mark is currently researching. David Sinclair How to modulate hormones to prevent aging and disease. Why detoxication gets less efficient as we get older. [01:39:55] The Essence of Nootopia How Nootopia collaborates with scientists to deliver the best products. The reason why Mark and his team meditate in their meetings. Where Nootopia sources their ingredients. The Last of Us [01:48:20] Zamner Juice: A Solution for Entrepreneurs How Zamner Juice increases verbal fluency. 482 Dave Asprey | Advanced Biohacking For Body Mind & Spirit: How To Train A Healthy Brain, Boost Your Flow State + Remove False Beliefs The science of processing cordyceps. Why they‘re searching for a solution to the oil crisis. The Ultimate Nutrition Bible: Easily Create the Perfect Diet that Fits Your Lifestyle, Goals, and Genetics by Matt Gallant and Wade Lightheart Leave Wellness + Wisdom a Review on Apple Podcasts Power Quotes From The Show Chronic Stress "It's almost like we're carrying around IVs and every few seconds there's a little drip of stress. Our ancestors had stress but it wasn't like ours. We are in chronic stress all the time. And because it doesn't necessarily hit instantaneously, meaning the buildup of these toxins is happening but you don't notice when it starts happening. When it suddenly builds up to the point where you have massive brain fog." - Mark Effinger Surplus in Life "Once you start finding that extra 10, 20, 30, or 50% of available surplus in your life, the things that will start showing up that allow you to pause and reflect, and if you internalize them and say "what does that thing mean to me?" I guarantee you will find some event, person, possibility, or opportunity that will become the catalyst for the biggest future." - Mark Effinger Nootropics: The Bridge to Greater Cognitive Capacity "Nootropics can be a bridge to psychedelics. It isn't the euphoria necessarily.It isn't the out-of-body experience. It's not the loss of ego. But it is a bridge to more cognitive bandwidth, more capacity to deal with cognitive load, more opportunity to laterally think, to be creative, to explore some of the things instead of that shrinking in of ourself." - Mark Effinger Links From Today's Show  Mark Effinger Nootopia - 10% off with code: "JOSH10" 497 Mark Effinger | Brain + Mood Optimization: Become Unstoppable With Nootropics Nootropics as Cognitive Enhancers: Types, Dosage and Side Effects of Smart Drugs Collagenius - 10% off with code "JOSH10" Elon Musk My First Million Podcast The Top 5 Neurotransmitters from a Clinical Neurologist's Perspective Charlie Rose Bryan Johnson Clean Fifteen David Goggins Maria Bamford David Sinclair The Last of Us 482 Dave Asprey | Advanced Biohacking For Body Mind & Spirit: How To Train A Healthy Brain, Boost Your Flow State + Remove False Beliefs The Ultimate Nutrition Bible: Easily Create the Perfect Diet that Fits Your Lifestyle, Goals, and Genetics by Matt Gallant and Wade Lightheart Josh's Trusted Products | Up To 40% Off Shop All Products BREATHE - 33% off with the code “PODCAST33” SiPhox - 10% off with code "JOSH" Holy Hydrogen - $100 off with code "JOSH" SinuSonic - 15% off with "JOSH15" Organifi - 20% off with the code ‘WELLNESSFORCE' QI-Shield EMF Device - 20% off with the code "JOSH" SEED Synbiotic - 30% off with the code "JOSHTRENT" BON CHARGE - 15% off with the code "JOSH15" MANNA Vitality - 20% off with the code "JOSH20" SimplyO3 - 10% off with code "JOSH10" Kineon - 10% off with code "JOSH10" Mendi.io - 20% off with the code "JOSH20" Adapt Naturals - 15% off with code "WELLNESSFORCE" SpectraSculpt - 15% off with the code "JOSH15" SaunaSpace - 10% off with the code "JOSH10" Cured Nutrition CBD - 20% off with the code "WELLNESS FORCE" PLUNGE - $150 off with the code “WELLNESSFORCE" LiftMode - 10% off with the code "JOSH10" MitoZen - 10% off with the code “WELLNESSFORCE” Paleovalley - 15% off with the link only NOOTOPIA - 10% off with the code "JOSH10" Activation Products - 20% off with the code “WELLNESSFORCE” SENSATE - $25 off with the code "JOSH25" BiOptimizers - 10% off with the code "JOSH10" ION - 15% off with the code ‘JOSH15' Feel Free from Botanic Tonics - $40 off with the code "WELLNESS40" Essential Oil Wizardry - 10% off with the code "WELLNESSFORCE" ALIVE WATERS - 33% off your first order with the code "JOSH33" Earth Runners Shoes - 10% off with code "JOSH10" DRY FARM WINES - Get an extra bottle of Pure Natural Wine with your order for just 1¢ Drink LMNT - Zero Sugar Hydration: Get your free LMNT Sample Pack, with any purchase Free Resources M21 Wellness Guide - Free 3-Week Breathwork Program with Josh Trent Join Wellness + Wisdom Community Limited Edition: Gold Pumpkin Spice from Organifi Save 20% with code "WELLNESSFORCE" on everyone's favorite Fall treat is here! Pumpkin Spice is more than just a taste phenomenon: it's a portal directly into the nostalgia of fall. With Gold Pumpkin Spice, that taste can also help promote relaxation and restful sleep, nourish the body, and support nightly recovery from a hard day's work.  Click HERE to order your Organifi today including the Green, Red, and traditional Gold! Are You Stressed Out Lately? Take a deep breath with the M21™ wellness guide: a simple yet powerful 21 minute morning system that melts stress and gives you more energy through 6 science-backed practices and breathwork. Click HERE to download for free. Experience Red Light Therapy at HomeSave 10% on your SaunaSpace order with the code "JOSH10" Unlike the traditional methods, near-infrared light works with your body's biology to create radiant heat from the inside out. By using near-infrared's shorter wavelengths in a way that mimics natural sunlight, the light penetrates deeply to raise your core temperature faster. *Review The Wellness + Wisdom Podcast & WIN $150 in wellness prizes! About Mark Effinger Mark Effinger is a seasoned entrepreneur and intrapreneur with specialties in biochemistry and hormone and brain optimization. He is successful in industries from marketing to lasers to software. Companies turn to him for his clear grasp of the startup-to-sellout process. The death of Mark's former wife from a painkiller overdose put him on the path to creating high-performance nutritional supplements. After 4 years of development, he released a product called “Limitless NZT-48,” as in the movie Limitless, with 3,500% growth over the first year (now 5,100% over 29 months). Mark considers the biggest challenge with nootropics to be that everyone's brain chemistry is unique. For the first time ever, Nootopia has solved this with a personalized process and product. They use your information to evaluate your goals and brain chemistry, then customize their nine core blends. Whether you want to say goodbye to afternoon energy crashes, increase your verbal fluency, boost your emotional intelligence, or reach other optimization goals, Nootopia gets you 100% personal help every single day. The system even comes with an app that guides you every step of the journey and allows you to give feedback to customize your blends even further. Mark's vision is for the resources from the company to move the needle in terms of making a difference while they make healthy profits. He firmly believes that Nootopia can add value both locally and globally. Website - Mark Effinger Website - Nootopia Instagram - Mark Effinger Instagram - Nootopia Twitter - Mark Effinger Facebook - Mark Effinger Facebook - Nootopia Real-life "Limitless" Pill? This Breakthrough Nootropics Stack Gives You The Winning Edge Don't Miss New Episodes: Follow Wellness + Wisdom on Spotify

When writing about health and fitness, I often weave hormones into the discussion. I'm asked more about hormones than most other topics, as well. But there's another crucial category of communicators that deserves equal attention: neurotransmitters. These chemicals have a massive influence on how you feel, think, and even how you perform. They're often overlooked in mainstream health discussions, but understanding them can be a game-changer for your well-being. In this guide, we will dig deep into neurotransmitters: what they are, how they're different from hormones, and why you should care about them for your overall health. The Difference Between Hormones and Neurotransmitters Hormones are like the body's long-distance messengers. Produced by glands in the endocrine system, they travel through the bloodstream to deliver signals to various tissues and organs.Marieb, E. N., & Hoehn, K. (2018). Human Anatomy & Physiology (11th ed.). Pearson. They're behind a lot of what happens in your body, from controlling your metabolism to regulating your sleep cycles. Neurotransmitters, on the other hand, are more like local couriers. They operate mainly in the brain, helping neurons communicate with each other.Kandel, E. R., Schwartz, J. H., & Jessell, T. M. (2000). Principles of Neural Science (4th ed.). McGraw-Hill. Unlike hormones, they don't travel long distances. They make their impact in the tiny spaces between neurons, called synapses, and their effects are often immediate. Key Differences Speed of Action: Neurotransmitters work fast, almost instantly. Hormones usually take more time to show their effects. Range of Influence: Hormones can affect multiple systems throughout the body. Neurotransmitters usually have a more localized impact, especially within the brain. Regulatory Mechanisms: Hormones are typically regulated by feedback loops involving multiple organs. Neurotransmitters are primarily regulated within the nervous system. How Neurotransmitters Impact Your Health Physical Health Dopamine and norepinephrine aren't just about feeling good; they're about energy optimization. These neurotransmitters act in the brain's arousal system, influencing both wakefulness and alertness. Low levels can lead to symptoms akin to chronic fatigue syndrome, affecting not just your mood but also your physical stamina.Tumilty, S., et al. (2018). The effects of norepinephrine on hemodynamics and oxygen metabolism in hyperdynamic sepsis. Journal of Intensive Care Medicine, 33(6), 357-364. Physical Performance Acetylcholine is a neurotransmitter that you might not have heard of, but it's crucial for anyone interested in physical performance. It acts as the messenger between your nerves and muscles, facilitating the contraction that allows for movement. A deficiency in acetylcholine can lead to muscle weakness and decreased athletic performance.Deschenes, M. R., & Wilson, M. H. (2003). Age-related differences in synaptic plasticity following muscle unloading. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 58(8), B678-B687. Mental Health When it comes to mood regulation, serotonin and dopamine are the big players. An imbalance in serotonin levels has been directly linked to mood disorders like depression and anxiety. Dopamine also plays a role in how we perceive pleasure and reward, which impacts our emotional well-being.Wise, R. A. (2004). Dopamine, learning and motivation. Nature Reviews Neuroscience, 5(6), 483-494. Acetylcholine doesn't just affect your muscles; it's also vital for your brain. It plays a significant role in attention, learning, and memory. Studies have found that decreased acetylcholine levels are associated with cognitive impairments, including those seen in Alzheimer's disease.Schliebs, R., & Arendt, T. (2011). The cholinergic system in aging and neuronal degeneration. Behavioural Brain Research, 221(2), 555-563.

Download for FREE today -  special Mnemonics Cheatsheet - so you can be SURE that you have that Must Know information down:  bit.ly/nursing-memory   Outline SLUD S-Salivation L-Lacrimation U-Urination D-Defecation Description A cholinergic crisis can occur if the body stops properly breaking down Acetylcholine. This can cause overactivity of Acetylcholine at the neuromuscular junction. Acetylcholine is part of Rest & Digest (Parasympathetic) – so we see overactive digestion and secretion.

Download for FREE today -  special Mnemonics Cheatsheet - so you can be SURE that you have that Must Know information down:  bit.ly/nursing-memory   Outline SLUDGE S-Salivation L-Lacrimation U-Urination D-Defecation G-Gastric upset E-Emesis Description A cholinergic crisis can occur if the body stops properly breaking down Acetylcholine. This can cause overactivity of Acetylcholine at the neuromuscular junction. Acetylcholine is part of Rest & Digest (Parasympathetic) – so we see overactive digestion and secretion.

Noradrenaline (norepinephrine) is a neurotransmitter and hormone that plays a role in the body's "fight or flight" response.  Acetylcholine is a neurotransmitter (“brain” +” across” + “to send”) that helps transmit signals in the brain and body. Its name comes from its chemical structure, an acetate group and a choline molecule.  Dopamine is a neurotransmitter that plays a role in motivation, reward, and movement. Its name comes from its chemical structure, a combination of two molecules called dihydroxyphenylalanine and dopamine. Adrenaline (epinephrine) is a hormone and neurotransmitter that helps the body respond to stress. Its name comes from its source, the adrenal glands.  Serotonin is a neurotransmitter that is involved in mood, appetite, and sleep. Its name comes from its chemical structure, a combination of sero- (meaning "serum") and -tonin (meaning "tonic" or "substance that modifies").  Corticotropin-releasing hormone (CRH) is a hormone that stimulates the release of cortisol, a stress hormone. The name comes from its function of stimulating the release of corticotropin, a hormone that stimulates the adrenal glands. Also, it gets its name from its role in stimulating the release of adrenocorticotropic hormone (ACTH) from the pituitary gland, which in turn stimulates the release of cortisol from the adrenal gland. Vasopressin is a hormone that regulates water balance in the body. Its name comes from its ability to constrict blood vessels (vasoconstriction) and increase blood pressure. Vasopressin, also known as antidiuretic hormone (ADH), is so named because it regulates water balance by causing the kidneys to reabsorb water. Thyrotropin-releasing hormone (TRH) is a hormone that stimulates the release of thyroid-stimulating hormone (TSH), which regulates the thyroid gland. Its name comes from its function of stimulating the release of thyrotropin.  Oxytocin is a hormone that is involved in social bonding, childbirth, and lactation. Its name comes from its ability to stimulate uterine contractions (oxytocic) and milk ejection (lactogenic).  Gonadotropin-releasing hormone (GnRH) is a hormone that stimulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which regulate the reproductive system. Its name comes from its function of stimulating the release of gonadotropins.  Growth hormone–releasing hormone (GHRH) is a hormone that stimulates the release of growth hormone (GH), which regulates growth and metabolism. Its name comes from its function of stimulating the release of growth hormone.  Catecholamines are a group of hormones and neurotransmitters that includes adrenaline, noradrenaline, and dopamine. Their name comes from their chemical structure, which includes a catechol group and an amine group.  Histamine is a neurotransmitter and hormone that is involved in inflammation, allergies, and gastric acid secretion. ACTH (adrenocorticotropic hormone) is a hormone that stimulates the release of cortisol from the adrenal glands.  Orexin (hypocretin) is a neurotransmitter that is involved in wakefulness and appetite. Its name comes from its discovery in the hypothalamus and its ability to stimulate food intake (orexigenic).  Glutamic acid (glutamate) is a neurotransmitter that is involved in learning, memory, and neural plasticity. Its name comes from its chemical structure, a combination of glutamine and an acid group.  Galanin is a neuropeptide that is involved in pain perception, mood, and appetite. Its name comes from its discovery in the galanin-containing neurons of the hypothalamus.  Neurotensin comes from the words "neuro," meaning related to nerves, and "tensin," which refers to its ability to cause contraction in smooth muscle. Neurotensin is a neuropeptide that is found in the central nervous system and gastrointestinal tract. --- Support this podcast: https://podcasters.spotify.com/pod/show/liam-connerly/support

We are diving in to all things neurotransmitters and synaptic signaling to kick off the January 2023 series. You'll hear about dopamine, noradrenaline, prion proteins, a new 3D cell culture model, and more, in today's episode. Enjoy!  Sections in this episode:  Monoamine Neurotransmitters (3:50)  Glutamate (9:18)  Acetylcholine (15:51)  Synaptic Proteins (17:43)  New 3D Culture Method (21:32) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/106pvyu5qprE3dW0j2RieICqJF0Hdsyu7/view?usp=share_linkTo access the folder with ALL our bibliographies, follow this link (it will be updated as we publish episodes and process bibliographies), or use the link below:https://drive.google.com/drive/folders/1bzSzkY9ZHzzY8Xhzt0HZfZhRG1Gq_Si-?usp=sharingYou can also find all of our bibliographies on our website: amindr.com. --------------------------------------------------------------Follow-up on social media for more updates!Twitter: @AMiNDR_podcastInstagram: @AMiNDR.podcastFacebook:  AMiNDR  Youtube: AMiNDR PodcastLinkedIn: AMiNDR PodcastEmail: amindrpodcast@gmail.com  -------------------------------------------------------------- Please help us spread the word about AMiNDR to your friends, colleagues, and networks! And if you could leave us a rating and/or review on your streaming app of choice (Apple Podcasts, Spotify, or wherever you listen to the podcast), that would be greatly appreciated! It helps us a lot and we thank you in advance for leaving a review! Don't forget to subscribe to hear about new episodes as they come out too. Thank you to our sponsor, the Canadian Consortium of Neurodegeneration in Aging, or CCNA, for their financial support of this podcast. This helps us to stay on the air and bring you high quality episodes. You can find out more about the CCNA on their website: https://ccna-ccnv.ca/. Our team of volunteers works tirelessly each month to bring you every episode of AMiNDR. This episode was scripted and hosted by Ellen Koch, edited by Michelle Grover, and reviewed by Judy Cheng and Anusha Kamesh. The bibliography and wordcloud were made by Lara Onbasi (www.wordart.com). Big thanks to the sorting team for taking on the enormous task of sorting all of the Alzheimer's Disease papers into episodes each month. For January 2023, the sorters were Elyn Rowe, Christy Yu, Eden Dubchak, Ben Cornish, Kevin Nishimura, Anelya Gandy, Salodin Al-Achkar, and Rob Cloke. Also, props to our management team, which includes Sarah Louadi, Ellen Koch, Naila Kuhlmann, Elyn Rowe, Anusha Kamesh, Lara Onbasi, Joseph Liang, and Judy Cheng, for keeping everything running smoothly.Our music is from "Journey of a Neurotransmitter" by musician and fellow neuroscientist Anusha Kamesh; you can find the original piece and her other music on soundcloud under Anusha Kamesh or on her YouTube channel, AKMusic.   https://www.youtube.com/channel/UCMH7chrAdtCUZuGia16FR4w   -------------------------------------------------------------- If you are interested in joining the team, send us your CV by email. We are specifically looking for help with sorting abstracts by topic, abstract summaries and hosting, audio editing, creating bibliographies, and outreach/marketing. However, if you are interested in helping in other ways, don't hesitate to apply anyways.  --------------------------------------------------------------*About AMiNDR: *  Learn more about this project and the team behind it by listening to our first episode: "Welcome to AMiNDR!" 

Ellen kicks off the November 2022 series with 11 papers about synaptic transmission and neurotransmitters in Alzheimer's disease. Hear about glutamate, acetylcholine, synaptic proteins, and more in this jam-packed episode!  Sections in this episode:  Glutamate and Acetylcholine (4:01)  GABA neurons (10:52)  Neuron Excitability (12:15)  Synaptic Proteins (15:10)  Neuro-Immuno-Endocrine System (21:45) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1dELth-9F_TVyUTuxPmuIVYKM1MgCuIEf/view?usp=share_linkTo access the folder with ALL our bibliographies, follow this link (it will be updated as we publish episodes and process bibliographies), or use the link below:https://drive.google.com/drive/folders/1bzSzkY9ZHzzY8Xhzt0HZfZhRG1Gq_Si-?usp=sharingYou can also find all of our bibliographies on our website: amindr.com. --------------------------------------------------------------Follow-up on social media for more updates!Twitter: @AMiNDR_podcastInstagram: @AMiNDR.podcastFacebook:  AMiNDR  Youtube: AMiNDR PodcastLinkedIn: AMiNDR PodcastEmail: amindrpodcast@gmail.com  -------------------------------------------------------------- Please help us spread the word about AMiNDR to your friends, colleagues, and networks! And if you could leave us a rating and/or review on your streaming app of choice (Apple Podcasts, Spotify, or wherever you listen to the podcast), that would be greatly appreciated! It helps us a lot and we thank you in advance for leaving a review! Don't forget to subscribe to hear about new episodes as they come out too. Thank you to our sponsor, the Canadian Consortium of Neurodegeneration in Aging, or CCNA, for their financial support of this podcast. This helps us to stay on the air and bring you high quality episodes. You can find out more about the CCNA on their website: https://ccna-ccnv.ca/. Our team of volunteers works tirelessly each month to bring you every episode of AMiNDR. This episode was scripted, hosted, and edited by Ellen Koch, and reviewed by Anelya Gandy and Anusha Kamesh. The bibliography and wordcloud were created by Lara Onbasi (www.wordart.com). Big thanks to the sorting team for taking on the enormous task of sorting all of the Alzheimer's Disease papers into episodes each month. For November 2022, the sorters were Sarah Louadi, Eden Dubchak, Ben Cornish, Christy Yu, Dana Clausen, Kevin Nishimura, Anelya Gandy, Salodin Al-Achkar, Ellen Koch, and Elyn Rowe. Also, props to our management team, which includes Sarah Louadi, Ellen Koch, Naila Kuhlmann, Elyn Rowe, Anusha Kamesh, Lara Onbasi, Joseph Liang, and Judy Cheng, for keeping everything running smoothly.Our music is from "Journey of a Neurotransmitter" by musician and fellow neuroscientist Anusha Kamesh; you can find the original piece and her other music on soundcloud under Anusha Kamesh or on her YouTube channel, AKMusic.   https://www.youtube.com/channel/UCMH7chrAdtCUZuGia16FR4w   -------------------------------------------------------------- If you are interested in joining the team, send us your CV by email. We are specifically looking for help with sorting abstracts by topic, abstract summaries and hosting, audio editing, creating bibliographies, and outreach/marketing. However, if you are interested in helping in other ways, don't hesitate to apply anyways.  --------------------------------------------------------------*About AMiNDR: *  Learn more about this project and the team behind it by listening to our first episode: "Welcome to AMiNDR!" 

When you have more intellectual bandwidth and mental capacity, it reflects in every area of your body. Instead of having this radical hormone flood, fight or flight, during a perceived negative event, you can look at the event without all of that emotional overhead. Because instead of your head thinking: “Oh crap, this event's happening, it's going to wipe me out, and I'm not going to be effective…”, you can look at it, almost laugh about it: “Ok, bring it… Let's do this thing. - Mark Effinger Are You Stressed Out Lately? Take a deep breath with the M21™ wellness guide: a simple yet powerful 21 minute morning system that melts stress and gives you more energy through 6 science-backed practices and breathwork. Click HERE to download for free. Is Your Energy Low? Get more superfoods to improve your energy, digestion, gut health plus also reduce inflammation and blood sugar. Click HERE to try Paleovalley's Apple Cider Vinegar Complex + Save 15% with the code 'JOSH' *Review The WF Podcast & WIN $150 in wellness prizes! *Join The Facebook Group Wellness + Wisdom Episode 497 Mark Effinger, Founder of BiOptimizers and Nootopia, joins the host, Josh Trent, to discuss the real-life "Limitless pill." And although all of us have unique brain chemistry, Mark and his team managed to create a personalized product for the most efficient brain and mood optimization yet developed. Are you looking for an effective way to enhance your mood and brain function? Learn how Nootropics positively affect the neurotransmitters in our body with Mark Effinger and Josh Trent. By the end of this episode, you will understand what inspired Mark to create Nootopia, how Nootropics contribute to healing anxiety and depression, and how they optimize your brain for improved focus, memory, and motivation.   Nootopia Nootopia: UNLOCK YOUR BRAIN'S Maximum Focus, Concentration, And Creativity Boost your cognitive performance Think through more tasks without burnout Manage more projects without rising stress Handle more mental stress without bending or breaking Increase your capacity to learn new things quickly and effortlessly Articulate things better in a more meaningful way   Save 10% with the code “JOSH10”    Listen To Episode 497 As Mark Effinger Uncovers: [1:30] Nootropics 101 BiOptimizers Nootopia - Save 10% with code "JOSH10" Wade Lightheart Paul Chek How Josh first heard about Nootopia and BiOptimizers. What nootropics specifically are and why they're so beneficial. Mark tells a story about his deceased wife. His own wellness journey and health crisis led him to pursue a career in the wellness industry. How he gained his work ethic, and how it helped him become an entrepreneur and create several companies. Why he took Accutane, got precancerous conditions from it, and his skin cracked open during a rock band performance at a church camp. His thyroid failure: Why it's essential to prioritize our lives over our work. Dr. Michael Ruscio | Hypothyroidism, Thyroid Symptoms, & The Truth About Hypothyroid   [15:00] Striving For Health In A Toxic World How Nootropics came to Mark's life: Finding out from a doctor at a B&B that he has hypothyroidism and discovering Acetylcholine through a radio show. What the neurotransmitter Acetylcholine is good for. Dietary issues: How are we being lied to about our food? Mycotoxins: Disease-causing fungi found in animal products and the reason why you should only eat organic or compound meat. 482 Dave Asprey | Advanced Biohacking For Body Mind & Spirit: How To Train A Healthy Brain, Boost Your Flow State + Remove False Beliefs The reason Mark would not dive into the Mississippi River and how the Gulf of Mexico is being destroyed. Why our attempts to become healthy are actually toxifying us: Our natural biochemical reactions VS chemical supplements.   [21:30] From Addictions to Nootopia Neurohacker Nootopia UpBeat Nootopia Zamner Juice joshtrent.com/nootopia- Save 10% with the code "JOSH10" 483 Wayland Myers | NonViolent Communication: How to Stop Arguments In 60 Seconds + The Power of Loving Detachment Mark uncovers how Nootopia came to life: His wife getting on painkillers after giving birth to their first child, becoming addicted, and committing suicide. How the exposure to addiction through his wife and older sibling made him search for a solution to get people out of addictive behavior. His background as a biochemist: Building a human growth hormone stimulating component and a light nootropic.   [27:00] Orchestrating Neurochemicals Neurochemical research: Getting feedback on his prototypes from his clients. Mark explains what Pyroglutamic acid is and why he tested it together with Acetylcholine on himself to discover the effects. Creating Nootopia to make a change and help people with addiction and cognitive decline. 123 Aubrey Marcus – Own The Day How he discovered his prototypes made him sleepy and started looking at new components: Anti-inflammatories, antioxidants, and B vitamins. Why it's important to use precursors and signaling molecules. How he understood and put together all ingredients that serve different purposes: Get rid of inflammation, and boost brain function, memory and motivation. How creating the perfect formula compares to conducting an orchestra. Limitless (2011) - link to Amazon DVD purchase   [34:00] How Zamner Juice Helps Regulate Your Mood How you can make your performance a predictable part of your day. Key things to know about stack development and what they have done with it at Nootopia specifically with the Zamner Juice. The component that they have in every single one of their stacks and how it helps the brain improve mood, neurochemicals, and neurogenesis. How Nootopia designs their stacks to keep you focused and alert but not overstimulated like you might experience with caffeine. Why Zamner Juice is safe for expecting mothers to help them with mood regulation. What is specifically in Zamner Juice that helps people calm down.   [34:30] Business + A Spiritual Journey Why Josh appreciates the place that Mark came from creating Nootopia. Peter Gabriel: Solsbury Hill Matt Gallant Brad Costanzo WebNutrients (now Nootopia) The reason Mark didn't want to sell his company and why he believes making his products is a spiritual journey. How caffeine actually makes us tired earlier, why you shouldn't drink it during the first 90 minutes after you wake up, and the purpose of dopamine.   [41:30] Toxicity, Road Rage, And The Nootropics Solution The biochemical reactions in our body in the morning and why it's important to set an intention for the day. How serotonin helps us connect with others and speak without fear. Neurochemical balance: Preventing our flow from being blocked. How chronic emotional distress is slowly breaking us down without us noticing. Why Mark was always expecting bad things to happen to him. How our mind and soul are connected to each other, and how our environment has become toxic to us. Road rage: The story of developing the Zamner Juice to calm people down in traffic. The connection between our bad eating habits and our energy deficit. Why he carefully selects music with positive lyrics and the words he uses to create conversations with other people.   [52:00] Creating Indomitable Human Beings How cognitive enhancement became a byproduct of Nootopia's products. Neurogenesis: New neurons that we can program to states of positivity, faster thinking, and love to become indomitable human beings. Mark's journey to meditation: Starting transcendental meditation at the age of 8 at school. The difference between “having to do things” and “getting to do things.”   [57:30] Mark's Journey and The Game of Life Why Mark believes he is fortunate, and how his past curiosity manifested in the present. The reason he still keeps his first chemistry set he got when he was a kid. How his journey led him to meet brilliant people and create a powerful supplement. What it means to be “in the game” and what can mess us up, especially when we are triggered. He explains how the team of PhDs aggregates knowledge and value to people. 046 Dr. John Gray: ADHD, Brain Health, & Sex Addiction 183 Dr. Kyra Bobinet | Living A Well Designed Life: 10 Lessons In Brain Science   [1:02:00] Optimizing The Brain To Make Conscious Decisions 465 Dr. Jin Ong | Emotional Triggers: Are They Your Best Teacher? How To Collapse Time + See The “Space In-Between” (The Art of Listening to Your Body) Why Josh doesn't watch horror movies because he doesn't want those toxic triggers to enter his mind. Cortisol and triggers: What happens in our body when we get triggered and how it affects our performance and reactions. Why we need to recognize what's happening and put it outside of ourselves. Mark reveals how he makes conscious decisions through his state optimization process, and why he doesn't rate these situations as good or bad. Kwai Chang Caine - Kung Fu TV series The Matrix - movie - add the Amazon affiliate dvd link Nootopia UpBeat Why he sold test tubes with tiny plastic baby figures in them and how it helped him start his first company. JoshTrent.com/Store   [1:09:30] Expectations VS Reality of Nootropics The reason Mark created 3,000 prototypes before he created the current Nootopia products. Why he started customizing the products and how it helped with the efficiency of the products. Josh's sensitivity to caffeine and the fact that he loves how Nootopia customized it to have little to zero caffeine in his products. Nootopia Apex People's expectations VS reality: Can you get the Limitless effect? Why some people function better in GABA and Serotonin, entering the flow state. Mark's negative experience using Adderall, and how he managed to create a natural supplement for the drug. Apex: Keeping people aware but not vigilant, and energized but not on edge. joshtrent.com/nootopia   [1:17:00] The Long-Term Effects of Nootropics The influence nootropics have on us long-term, even after we stop using them. How Josh relates his life to Neo from the Matrix movie. Mark's Facebook intro: Is your life by choice or by chance? Think and Grow Rich by Arthur R. Pell Why Mark thinks many people don't have intentions in their life and how it impacts them. What he wanted to accomplish at the age of 19 when we joined AirForce. Why it's important to make scary shifts in your life and recompose them. Joe Rogan 462 Ben Greenfield: Should You STOP Using Plant Medicines? Wisdom on Microdosing, The Muscle of Faith + How to Grow Your Spiritual Strength   [1:24:00] The Journey to Wellness 437 Josh Trent | Death & Rebirth: Why I'm Saying Goodbye to Wellness Force… How Josh opened up to the mystery and allowed himself to recreate himself. Collagenius 438 Justin Donald | Why Wellness Is A Pentagon: The Art of Financial Intelligence & Lifestyle Investing Breathwork.io What wellness means to Mark, and why he believes that abundance comes from our health. 10% off on Nootopia with "JOSH10"   Power Quotes From The Show Chemically Processed Supplements "We're buying our vitamins, not understanding which ones are chemically processed and which ones are naturally derived… In an attempt to become healthy, we are often times toxifying ourselves. So it's really important that we take a little bit of extra time to understand the difference between those two." - Mark Effinger   Changing Every Life You Touch "I was called to make a monumental contribution to every life I touch. And the way to do that seems to be this vehicle of meeting people like you (Josh), that have a heart for changing every life they touch." - Mark Effinger   Effective Vitamins "To make something that was really going to be effective, and put it into either a powder form or a capsule form, we needed to address the main things that kept people from performing. Number one was the inflammatory response; anti-inflammatories and antioxidants…The next was B-vitamin. Most people have a deficiency of B-vitamin… And then the Acetylcholine precursor layer so that your brain can create this thinking molecule." - Mark Effinger   Links From Today's Show BiOptimizers Nootopia - Save 10% with code "JOSH10" Nootopia UpBeat Nootopia Zamner Juice Wade Lightheart Paul Chek Dr. Michael Ruscio | Hypothyroidism, Thyroid Symptoms, & The Truth About Hypothyroid 482 Dave Asprey | Advanced Biohacking For Body Mind & Spirit: How To Train A Healthy Brain, Boost Your Flow State + Remove False Beliefs Neurohacker 483 Wayland Myers | NonViolent Communication: How to Stop Arguments In 60 Seconds + The Power of Loving Detachment 123 Aubrey Marcus – Own The Day Peter Gabriel: Solsbury Hill Matt Gallant Brad Costanzo WebNutrients (now Nootopia) 046 Dr. John Gray: ADHD, Brain Health, & Sex Addiction 183 Dr. Kyra Bobinet | Living A Well Designed Life: 10 Lessons In Brain Science 465 Dr. Jin Ong | Emotional Triggers: Are They Your Best Teacher? How To Collapse Time + See The “Space In-Between” (The Art of Listening to Your Body) Nootopia Apex Think and Grow Rich by Arthur R. Pell Joe Rogan 462 Ben Greenfield: Should You STOP Using Plant Medicines? Wisdom on Microdosing, The Muscle of Faith + How to Grow Your Spiritual Strength 437 Josh Trent | Death & Rebirth: Why I'm Saying Goodbye to Wellness Force… 438 Justin Donald | Why Wellness Is A Pentagon: The Art of Financial Intelligence & Lifestyle Investing Shop the Wellness Force Media Store breathwork.io Paleovalley – Save 15% on your ACV Complex with the code ‘JOSH' Seeking Health - Save 10% with the code 'JOSH' Organifi – Special 20% off to our listeners with the code ‘WELLNESSFORCE' Drink LMNT – Zero Sugar Hydration: Get your free LMNT Sample Pack, you only cover the cost of shipping Feel Free from Botanic Tonics – Save 40% when you use the code ‘WELLNESS40' PLUNGE - Save $150 with the code "WELLNESSFORCE' MitoZen - Save 10% with the code "WELLNESSFORCE" Activation Products - Save 20% with the code "WELLNESSFORCE" Essential Oil Wizardry: Save 10% with the code 'WELLNESSFORCE' Cured Nutrition – Get 15% off of your order when you visit wellnessforce.com/cured + use the code ‘WELLNESSFORCE' M21 Wellness Guide Wellness Force Community Leave Wellness Force a review on iTunes Mark Effinger Instagram Twitter Facebook   About Mark Effinger Mark is a seasoned entrepreneur and intrapreneur with specialties in biochemistry and hormone and brain optimization. He is successful in industries from marketing to lasers to software. Companies turn to him for his clear grasp of the startup-to-sellout process. The death of Mark's former wife from a painkiller overdose put him on the path to creating high-performance nutritional supplements. After 4 years of development, he released a product called “Limitless NZT-48,” as in the movie Limitless, with 3,500% growth over the first year (now 5,100% over 29 months). Mark considers the biggest challenge with nootropics to be that everyone's brain chemistry is unique. For the first time ever, Nootopia has solved this with a personalized process and product. They use your information to evaluate your goals and brain chemistry, then customize their nine core blends. Whether you want to say goodbye to afternoon energy crashes, increase your verbal fluency, boost your emotional intelligence, or reach other optimization goals, Nootopia gets you 100% personal help every single day. The system even comes with an app that guides you every step of the journey and allows you to give feedback to customize your blends even further. Mark's vision is for the resources from the company to move the needle in terms of making a difference while they make healthy profits. He firmly believes that Nootopia can add value both locally and globally.  

Maintaining healthy levels of vitamin D and the B vitamins is essential for health and is moderated through the microbiome. Learn how deficiencies in these nutrients are related to a brain chemical called acetylcholine, which in turn impacts anxiety, insomnia, infertility, IBS, Parkinson's, Alzheimer's and ADHD. Learn more about how to maintain a healthy balance of your B vitamins and vitamin D with Stasha Gominak MD, neurologist and sleep coach. Lindsey Parsons, your host, helps clients solve gut issues and reverse autoimmune disease naturally. Take her quiz to see which stool or functional medicine test will help you find out what's wrong. She's a Certified Health Coach at High Desert Health in Tucson, Arizona. She coaches clients locally and nationwide. You can also follow Lindsey on Facebook, Twitter, Instagram or Pinterest or reach her via email at lindsey@highdeserthealthcoaching.com to set up a free 30-minute Gut Healing Breakthrough Session. Show Notes

A cholinergic crisis can occur if the body stops properly breaking down Acetylcholine. This can cause overactivity of Acetylcholine at the neuromuscular junction. Acetylcholine is part of Rest & Digest (Parasympathetic) – so we see overactive digestion and secretion.  

Just how can I boost my brain? if you do not work out currently would certainly be a wonderful time to begin. Do not assault workout yet accept it. You will certainly drive a lot more oxygen to your mind as well as you will certainly see that you will certainly rest much better in the evening. I recommend that you work out prior to you consume. This will certainly enable your body's gets of kept glycogen to be consumed. Escaping from the common American diet regimen of refined foods high in bad fats as well as sugar will certainly go a long way to maintaining your mind functioning much better for many years to find.You might not think of researching brand-new points considering that you left university. Your mind was running a great deal far better at that time in addition to the remainder of your body. When you compel your mind to believe you boost the mind. This procedure is called neuroplasticity. Your mind can remain to broaden at any kind of age. It might not be as reliable as it was when you remained in institution, however you can expand nerve cells right into your 80s. Nerve cells are afferent neuron.Supplements for Brain HealthFish oils are vital to mind wellness. Omega-3s bring a little whatever, consisting of enhanced mind memory, response, and also feature times. They might likewise decrease the threat of Alzheimer's condition, as well as possibly also assist stop clinical depression and also mental deterioration.B6 B9 B12 all assistance enhance mind feature. These effective B vitamins aid lessen sugar damage to afferent neurons as well as assist tame swelling by minimizing degrees of homocysteine. Homocysteine is a pen for swelling in the body, that includes the mind. When you supplement with the B vitamins, do not be shocked if you observe much less clinical depression and also much better memory recall.Huperzine A is a newbie to mind wellness yet it is an effective enhancement. You have natural chemicals that inform nerves what to do. Among the most significant natural chemicals is acetylcholine. An excellent factor to take this supplement or nutraceutical is that it can boost memory as well as psychological feature. You will certainly be listening to a great deal even more concerning this moving forward. Acetylcholine is one of the most crucial natural chemical of the parasympathetic system which manages smooth muscular tissues, expands capillary, raises physical secretions, and also reduces the heart price.Eco-friendly green Tea has an amino acid called L-Theanine which has actually been revealed to minimize tension and also stress and anxiety. Individuals likewise see substantial renovations in state of mind as well as cognition. Include that it has practically no calories you must be changing diet plan or sweet beverages with eco-friendly tea prior to you shed your marbles.Vinpocetine can assist decrease your high blood pressure to name a few vital advantages to your mind. It has actually been made use of for over 30 years to deal with cerebrovascular problems like stroke as well as mental deterioration. If you are worried with improved mind metabolic rate as well as mind feature, begin including vinpocetine to your everyday supplements.Phosphatidylserine assists avoid amnesia as well as psychological decrease. Individuals that took This podcast welcomes your feedback here are several ways to reach out to me. If you have a topic you would like to hear about send me a message. I appreciate your listening. Dr. Brian Mc Kayhttps://twitter.com/DarienChiro/https://www.facebook.com/ChiropractorBrianMckayhttps://chiropractor-darien-dr-brian-mckay.business.sitehttps://podcasts.apple.com/us/podcast/not-just-chiropractor-for-stamford-darien-norwalk-new/id1503674397?uo=4

Dr. Peterson's extensive catalog is available now on DailyWire+: https://utm.io/ueSXh Dr. Jordan B. Peterson and Dr. Karl Friston discuss the world as we perceive it through micro narratives, how those narratives exist within a structured hierarchy, and how we can manipulate the system, and thus change our own mindsets. Dr. Karl Friston is a renowned neuroscientist, and one of the leading researchers in brain imagery. He is credited for inventing statistical parametric mapping, an international standard for the analysis of imaging data. His work also pertains to the free energy principle, and predictive coding theory. Currently, he works as a professor of neuroscience at the University College London. — Sponsors  — Hallow: Try Hallow for 3 months FREE: https://hallow.com/jordan Invest in art today with Masterworks at http://masterworks.art/jbp.See important disclosures at https://masterworks.com/cd. — Chapters — (0:00) Coming up(1:04) Intro(2:43) The binding of entropy(5:25) Motivation and Fantasy(15:00) Hierarchy of micro narratives(29:30) Frans de Waal, the paradox in prediction(37:50) Inference and assuming the story(46:15) Dopamine and diatic narratives(54:33) Serotonin, the depressive mindset(1:07:31) Acetylcholine(1:10:29) The need to minimize free energy(1:16:48) The left and right hemisphere(1:22:20) Psychedelics and functional narratives  // SUPPORT THIS CHANNEL //Newsletter: https://mailchi.mp/jordanbpeterson.com/youtubesignupDonations: https://jordanbpeterson.com/donate // COURSES //Discovering Personality: https://jordanbpeterson.com/personalitySelf Authoring Suite: https://selfauthoring.comUnderstand Myself (personality test): https://understandmyself.com // BOOKS //Beyond Order: 12 More Rules for Life: https://jordanbpeterson.com/Beyond-Order12 Rules for Life: An Antidote to Chaos: https://jordanbpeterson.com/12-rules-for-lifeMaps of Meaning: The Architecture of Belief: https://jordanbpeterson.com/maps-of-meaning // LINKS //Website: https://jordanbpeterson.comEvents: https://jordanbpeterson.com/eventsBlog: https://jordanbpeterson.com/blogPodcast: https://jordanbpeterson.com/podcast // SOCIAL //Twitter: https://twitter.com/jordanbpetersonInstagram: https://instagram.com/jordan.b.petersonFacebook: https://facebook.com/drjordanpetersonTelegram: https://t.me/DrJordanPetersonAll socials: https://linktr.ee/drjordanbpeterson #JordanPeterson #JordanBPeterson #DrJordanPeterson #DrJordanBPeterson #DailyWirePlus

One of the most important things a healthy brain needs is appropriate neurotransmitter activity. Neurotransmitters regulate our brain function, our energy, our focus, our mood, and our lives. Imbalances in neurotransmitters can come from many things, including past trauma, unhealthy relationships, bad habits, chronic stress, poor gut health, crappy diet, toxins, autoimmunity, neuroinflammation....the list goes on and on, but it can be helpful to know which neurotranmitters are imbalanced in the hopes of supporting your specific brain functions and symptoms. The most important neurotransmitters, which I discuss in this podcast, are:Serotonin - regulates some aspects of mood, appetite, happiness, enjoyment of activities, appreciation of art. Acetylcholine - regulates working memory, computation, muscle contractions, and parasympathetic nervous system (vagus nerve) activity to the gut.Dopamine - important for motivation, pleasure, focus, mood, addiction, thrill-seeking.Epinephrine/Norepinephrine - aka "adrenaline", stimulates "fight or flight" stress response centrally in the brain and also peripherally from the adrenal glands. GABA - the primary "calming" neurotransmitter, GABA is inhibitory and is often inadequate in symptoms of anxiety, depression, and neuroexcitation.These neurotransmitters can all be modulated with lifestyle strategies and targeted nutraceuticals, whether it be providing the building blocks for the neurotransmitters itself (tyrosine for dopamine for example), or impacting the receptor sensitivity (L-theanine for GABA), or using nutrients to support certain pathways like the Kynurenine Pathway, Dopamine Beta Hydroxylase, or other genetic pathways (COMT, MTHFR, MAO) of neurotransmitter metabolism. Supporting neurotransmitter metabolism can be a game changer when supporting brain function, and my goal is to teach people how to solve their own puzzles, so I hope this is helpful, next episode is part 3/4, brain regions!

Huberman Lab Podcast Notes “Nicotine is not the cause of cancer; nicotine is not the carcinogen. It's the other things in tobacco or associated with the nicotine delivering device that are causing cancer and the other negative impacts on our health.” – Dr. Andrew HubermanThe state nicotine puts your body in is almost the optimal state for getting mental work done: you feel alert, focused, and able to concentrate – but at the same time, your body feels relaxed (this is the behavioral side of why it's addictive)Nicotine has 4 major effects of nicotine on the brain and neural circuits: (1) triggers the release of dopamine and increases levels; (2) increases attention, focus, and concentration (via an increase in acetylcholine); (3) increases alertness and arousal (net effect of an increase in epinephrine & norepinephrine); (4) appetite suppressionThere is some evidence nicotine gum (not smoking, vaping, dipping, snuffing – those are never good) may increase cognitive performanceAll methods of ingesting nicotine are not the same: vaping is the most dangerous and most addictive because of the speed and concentration at which it hits the bloodstream and the rapidness at which dopamine spikes (until you need more and more)Why is it so hard to quit? The first week you stop, your dopamine is lower than baseline because you're not giving your body & brain the hit it's come to expect at a certain time so you feel much worse (remember the dopamine pleasure-pain balance)Withdrawal sets in about 4 hours after the last smoke or vape – people wake up in nicotine withdrawal and immediately need nicotineTip to quit smoking: change the method of cessation each week to intermittently reward the dopamine system without expectation – start with the patch, then gum, then nasal sprayRead the full notes @ podcastnotes.orgIn this episode, I explain how nicotine impacts the brain and body, including its potent ability to enhance attention, focus, and alertness, increase blood pressure and metabolism and reduce appetite. I discuss nicotine's ability to increase the action of neurochemicals, including dopamine, norepinephrine, and acetylcholine and activate sympathetic (alertness-promoting) neural circuits. I also discuss common nicotine delivery methods, such as cigarettes, vaping, dip, and snuff, and how they each create their own unique experience and how they, but not nicotine itself, cause cancer and other adverse health effects. I also explain science-based tools to permanently quit smoking cigarettes or vaping, including peer-reviewed clinical hypnosis tools, antidepressants, and alternative nicotine replacement (patches, lozenges, gums etc.). As nicotine is one of the most widely used substances with billions of users — most of whom report wanting to quit — this episode ought to be of interest to former/current nicotine users, those who want to quit smoking or vaping and/or those interested in learning the biology behind how nicotine impacts the brain and body. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman Thesis: https://takethesis.com/huberman InsideTracker: https://insidetracker.com/huberman ROKA: https://www.roka.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman For the full show notes, visit hubermanlab.com Timestamps (00:00:00) Nicotine (00:02:47) Momentous Supplements (00:03:41) Tool: Brief Daily Meditation & Focus (00:05:59) The Arrow Model of Focus, Alpha GPC & Garlic Supplements (00:10:43) Thesis, InsideTracker, ROKA (00:14:35) Nicotine Effects vs. Methods of Delivery, Acetylcholine (00:19:55) Where is Nicotine Found? Nicotinic Acetylcholine Receptors (00:25:12) Nicotine & Effects on the Brain: Appetite, Dopamine & GABA (00:30:58) AG1 (Athletic Greens) (00:32:11) Nicotine, Acetylcholine & Attentional “Spotlighting” (00:37:29) Nicotine, Norepinephrine & Alertness/Energy (00:41:10) Nicotine & Effects on Appetite & Metabolism (00:46:47) Nicotine & Effects on Body: Sympathetic Tone (00:51:29) Nicotine & Cognitive Work vs. Physical Performance (00:55:08) Nicotine Delivery Methods & Side Effects, Young People & Dependency (00:58:35) Smoking, Vaping, Dipping & Snuffing: Carcinogens & Endothelial Cells (01:02:34) Smoking, Vaping, Dipping & Snuffing: Negative Impacts on Lifespan & Health (01:09:23) How to Quit Smoking, Nicotine Cravings & Withdrawal (01:13:56) Vaping & Nicotine, Rates of Effect Onset, Dopamine, Addiction & Depression (01:25:06) Tool: Quitting Smoking & Clinical Hypnosis, Reveri (01:30:16) Bupropion (Wellbutrin) & Quitting Smoking (01:36:24) Tool: A Nicotine Replacement Schedule to Quit Smoking, Nicotine Patch/Gum (01:41:52) Tool: Biological Homeostasis & Nicotine Withdrawal, The “First Week” Strategy (01:51:39) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Neural Network Newsletter, Instagram, Twitter, Facebook Title Card Photo Credit: Mike Blabac Disclaimer

In this episode, I explain how nicotine impacts the brain and body, including its potent ability to enhance attention, focus, and alertness, increase blood pressure and metabolism and reduce appetite. I discuss nicotine's ability to increase the action of neurochemicals, including dopamine, norepinephrine, and acetylcholine and activate sympathetic (alertness-promoting) neural circuits. I also discuss common nicotine delivery methods, such as cigarettes, vaping, dip, and snuff, and how they each create their own unique experience and how they, but not nicotine itself, cause cancer and other adverse health effects. I also explain science-based tools to permanently quit smoking cigarettes or vaping, including peer-reviewed clinical hypnosis tools, antidepressants, and alternative nicotine replacement (patches, lozenges, gums etc.). As nicotine is one of the most widely used substances with billions of users — most of whom report wanting to quit — this episode ought to be of interest to former/current nicotine users, those who want to quit smoking or vaping and/or those interested in learning the biology behind how nicotine impacts the brain and body. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman Thesis: https://takethesis.com/huberman InsideTracker: https://insidetracker.com/huberman ROKA: https://www.roka.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman For the full show notes, visit hubermanlab.com Timestamps (00:00:00) Nicotine (00:02:47) Momentous Supplements (00:03:41) Tool: Brief Daily Meditation & Focus (00:05:59) The Arrow Model of Focus, Alpha GPC & Garlic Supplements (00:10:43) Thesis, InsideTracker, ROKA (00:14:35) Nicotine Effects vs. Methods of Delivery, Acetylcholine (00:19:55) Where is Nicotine Found? Nicotinic Acetylcholine Receptors (00:25:12) Nicotine & Effects on the Brain: Appetite, Dopamine & GABA (00:30:58) AG1 (Athletic Greens) (00:32:11) Nicotine, Acetylcholine & Attentional “Spotlighting” (00:37:29) Nicotine, Norepinephrine & Alertness/Energy (00:41:10) Nicotine & Effects on Appetite & Metabolism (00:46:47) Nicotine & Effects on Body: Sympathetic Tone (00:51:29) Nicotine & Cognitive Work vs. Physical Performance (00:55:08) Nicotine Delivery Methods & Side Effects, Young People & Dependency (00:58:35) Smoking, Vaping, Dipping & Snuffing: Carcinogens & Endothelial Cells (01:02:34) Smoking, Vaping, Dipping & Snuffing: Negative Impacts on Lifespan & Health (01:09:23) How to Quit Smoking, Nicotine Cravings & Withdrawal (01:13:56) Vaping & Nicotine, Rates of Effect Onset, Dopamine, Addiction & Depression (01:25:06) Tool: Quitting Smoking & Clinical Hypnosis, Reveri (01:30:16) Bupropion (Wellbutrin) & Quitting Smoking (01:36:24) Tool: A Nicotine Replacement Schedule to Quit Smoking, Nicotine Patch/Gum (01:41:52) Tool: Biological Homeostasis & Nicotine Withdrawal, The “First Week” Strategy (01:51:39) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Neural Network Newsletter, Instagram, Twitter, Facebook Title Card Photo Credit: Mike Blabac Disclaimer

Huberman Lab Podcast Notes Epinephrine/adrenaline, acetylcholine, and dopamine work together to facilitate the ability to get focused, direct focus, and stay focused over timeBinaural beats (40 Hz), white noise, pink noise, and brown noise can enhance focus & more importantly, decrease the amount of time it takes to get into a focused state by ramping up neurochemicalsBlocking time: use ultradian cycles (90-minute bouts) for intensely focused sessions; assume it will take about 5-10 minutes to ease in and then ramp up; when finished, spend 10-30 minutes to deliberately defocusBoth things are true: fasted states and fed states (sufficient glucose but not overly stuffed belly) stimulate neuronal activity – leverage this and try one focused 90-minute bout in the morning (fasted) and another in the afternoon (fed)Tip: leverage benefits of stress through cold exposure – try a cold shower (uncomfortably cold but safe to stay in) 1-5 minutes to increase epinephrine and dopamine in the brain and body to get the body into a focused state – the positive effects of epinephrine last up to an hour or moreFocus will drift unless you are an experienced meditator – the most important component of meditation is refocusing back to meditation and back to the breath – try 13 minutes per dayMeditation caveat: focused meditation in the 4 hours prior to bed actually hindered the ability to fall asleep and stay asleepUsing visual field to improve focus: set a timer for 30 seconds per day and try to focus on one object; keep adding 5 seconds per day looking directly at the location (be sure to blink!) – you can use this to help onramp into 90-minute focused boutAs always, start with behavioral tools (and dialing in sleep), then focus on nutrition, try supplementation – when all else fails and you've consulted a doctor, lean on prescription drugsReally sleep-deprived or having trouble focusing? Stack tools – for example, take a cold shower, leverage the visual field, and take alpha-GPCRead the full notes @ podcastnotes.orgIn this episode, I provide a list of behavioral, nutritional, and supplement-based tools you can use to improve your ability to get into a focused state to do mental or physical work. I explain science-supported strategies for transitioning into focus, maintaining focus during the work bout, and exiting the focus session, which is also critical, including decompression/defocusing tools. I explain when and how to use: binaural beats, caffeine, deliberate cold exposure, the pros and cons of working in fasted vs. fed states, and supplements and foods that enhance dopamine, epinephrine (i.e., adrenaline) and acetylcholine to promote optimal focus. Also, I explain how short behavioral practices, such as meditation and visual gaze training, will benefit your ability to focus over the long term. As deep focus is crucial to significantly improve cognitive or physical performance in any realm, this episode should be useful to anyone. By the end, you'll have an essential toolkit of science-supported, low- to zero-cost focus and concentration strategies to select from that can be tailored to your physical and mental performance needs. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman Thesis: https://takethesis.com/huberman LMNT: https://drinklmnt.com/huberman Eight Sleep: https://www.eightsleep.com/huberman Virtusan: https://virtusan.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman For the full show notes, visit hubermanlab.com Timestamps (00:00:00) Focus Toolkit  (00:04:25) Momentous Supplements  (00:05:38) Thesis, LMNT, Eight Sleep  (00:09:37) The “Arrow Model” of Focus: Epinephrine, Acetylcholine & Dopamine (00:15:15) Modulation vs. Mediation, Importance of Sleep (00:18:11) Tool: Binaural Beats to Improve Concentration  (00:20:54) Tool: White, Brown & Pink Noise, Transition to Focused State (00:22:55) Warm-Up for Cognitive Work, Refocusing Attention & Neuroplasticity  (00:26:14) Tool: Ultradian Cycles: Warm-Up, Maintaining Focus & Deliberate Defocusing  (00:31:22) How Many Daily Ultradian Cycles Can One Perform?  (00:34:14) AG1 (Athletic Greens) (00:35:35) Virtusan: Mental & Physical Health Journeys  (00:36:52) Tool: Fasted vs. Fed States & Focus, Prevent an Afternoon Crash, Ketosis (00:45:52) Tool: Foods to Improve Focus & Regulating Food Volume (00:47:53) Tool: Caffeine & Focused Work, Dopamine Efficacy, Alertness (00:52:55) Tool: Stress & Improved Concentration  (00:55:46) Tool: Deliberate Cold Exposure & Focus, Dopamine & Epinephrine  (01:00:39) Layer Focusing Tools & Design Your Own Protocols  (01:01:19) Tool: Short Meditation & Improved Ability to Refocus  (01:07:40) Tool: Yoga Nidra, Non-Sleep Deep Rest (NSDR) & Defocus Periods (01:12:13) Tool: Hypnosis & Focus/Deep Relaxation States (01:16:07) Optimal Time of Day to Use Specific Tools (01:16:46) Tool: Overt Visual Focus & Deliberate Gaze  (01:20:42) Covert Visual Focus; Deliberate Gaze Warm-Up & Focused Work  (01:24:43) Tool: Omega-3 Essential Fatty Acids  (01:27:28) Tool: Creatine Monohydrate  (01:29:10) Tool: Alpha-GPC & Acetylcholine, Increased Risk of Stroke? & Garlic  (01:33:52) Tool: L-Tyrosine Supplements & Food (01:34:47) Combining & Choosing Focus Tools, Variability  (01:36:50) ADHD Prescriptions, Training Neural Circuits, Maintenance & Reduced Dosage (01:39:19) Tool: Optimal Order Approaching Focus Tools, Prescriptions & Dependency  (01:42:56) Tool: Phenylethylamine & Dopamine (01:44:50) Tool: Other Supplements to Enhance Dopamine, Epinephrine & Acetylcholine  (01:46:46) Behavioral, Nutrition & Supplement Tools for Focus (01:49:12) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Momentous Supplements, AG1 (Athletic Greens), Instagram, Twitter, Neural Network Newsletter Title Card Photo Credit: Mike Blabac Disclaimer

In this episode, I provide a list of behavioral, nutritional, and supplement-based tools you can use to improve your ability to get into a focused state to do mental or physical work. I explain science-supported strategies for transitioning into focus, maintaining focus during the work bout, and exiting the focus session, which is also critical, including decompression/defocusing tools. I explain when and how to use: binaural beats, caffeine, deliberate cold exposure, the pros and cons of working in fasted vs. fed states, and supplements and foods that enhance dopamine, epinephrine (i.e., adrenaline) and acetylcholine to promote optimal focus. Also, I explain how short behavioral practices, such as meditation and visual gaze training, will benefit your ability to focus over the long term. As deep focus is crucial to significantly improve cognitive or physical performance in any realm, this episode should be useful to anyone. By the end, you'll have an essential toolkit of science-supported, low- to zero-cost focus and concentration strategies to select from that can be tailored to your physical and mental performance needs. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman Thesis: https://takethesis.com/huberman LMNT: https://drinklmnt.com/huberman Eight Sleep: https://www.eightsleep.com/huberman Virtusan: https://virtusan.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman For the full show notes, visit hubermanlab.com Timestamps (00:00:00) Focus Toolkit  (00:04:25) Momentous Supplements  (00:05:38) Thesis, LMNT, Eight Sleep  (00:09:37) The “Arrow Model” of Focus: Epinephrine, Acetylcholine & Dopamine (00:15:15) Modulation vs. Mediation, Importance of Sleep (00:18:11) Tool: Binaural Beats to Improve Concentration  (00:20:54) Tool: White, Brown & Pink Noise, Transition to Focused State (00:22:55) Warm-Up for Cognitive Work, Refocusing Attention & Neuroplasticity  (00:26:14) Tool: Ultradian Cycles: Warm-Up, Maintaining Focus & Deliberate Defocusing  (00:31:22) How Many Daily Ultradian Cycles Can One Perform?  (00:34:14) AG1 (Athletic Greens) (00:35:35) Virtusan: Mental & Physical Health Journeys  (00:36:52) Tool: Fasted vs. Fed States & Focus, Prevent an Afternoon Crash, Ketosis (00:45:52) Tool: Foods to Improve Focus & Regulating Food Volume (00:47:53) Tool: Caffeine & Focused Work, Dopamine Efficacy, Alertness (00:52:55) Tool: Stress & Improved Concentration  (00:55:46) Tool: Deliberate Cold Exposure & Focus, Dopamine & Epinephrine  (01:00:39) Layer Focusing Tools & Design Your Own Protocols  (01:01:19) Tool: Short Meditation & Improved Ability to Refocus  (01:07:40) Tool: Yoga Nidra, Non-Sleep Deep Rest (NSDR) & Defocus Periods (01:12:13) Tool: Hypnosis & Focus/Deep Relaxation States (01:16:07) Optimal Time of Day to Use Specific Tools (01:16:46) Tool: Overt Visual Focus & Deliberate Gaze  (01:20:42) Covert Visual Focus; Deliberate Gaze Warm-Up & Focused Work  (01:24:43) Tool: Omega-3 Essential Fatty Acids  (01:27:28) Tool: Creatine Monohydrate  (01:29:10) Tool: Alpha-GPC & Acetylcholine, Increased Risk of Stroke? & Garlic  (01:33:52) Tool: L-Tyrosine Supplements & Food (01:34:47) Combining & Choosing Focus Tools, Variability  (01:36:50) ADHD Prescriptions, Training Neural Circuits, Maintenance & Reduced Dosage (01:39:19) Tool: Optimal Order Approaching Focus Tools, Prescriptions & Dependency  (01:42:56) Tool: Phenylethylamine & Dopamine (01:44:50) Tool: Other Supplements to Enhance Dopamine, Epinephrine & Acetylcholine  (01:46:46) Behavioral, Nutrition & Supplement Tools for Focus (01:49:12) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Momentous Supplements, AG1 (Athletic Greens), Instagram, Twitter, Neural Network Newsletter Title Card Photo Credit: Mike Blabac Disclaimer

Episode 105: Antidotes to toxidromes. Some poisonings share common signs and symptoms and may be treated with antidotes without laboratory confirmation of the offending agent. Dr. Francis discussed with Dr. Arreaza some of those toxidromes and how to treat them. Written by Aida Francis, MD. Participation by Hector Arreaza, MD. Definitions: • Antidotes are substances given as a remedy that inhibit the effects of another drug of abuse or poison. Most are not 100% effective and fatality is still possible after administration. • Toxidrome is a constellation of signs and symptoms caused by an overdose or exposure to chemicals or drugs that interact with neuroreceptors. Toxidrome is the combination of the word “toxin” and “syndrome”. Management strategies of toxidromes are determined by the signs and symptoms even when the causative agent has not been identified. A little bit of Background: The World Health Organization reported that 13% of deaths caused by poisonings are children and young adults. Intentional poisoning attempts are more frequent among adolescent women than men. It is difficult to evaluate poisoned patients because they are too altered to provide history and there is often not enough time to perform a physical exam or obtain serum studies prior to life-saving interventions. To diagnose a toxidrome clinically, you need three elements: pupil size, temperature, and bowel sounds. For example: Pinpoint pupils with hyperactive bowel sounds point to cholinergic toxidrome, and dilated pupils with high temperature, and hypoactive bowel sounds point to anticholinergic (see details below). Pinpoint pupils -> Bowel sounds -> Hyperactive: CHOLINERGIC -> Hypoactive: OPIOIDS Normal or dilated pupils -> Temperature -> High -> Bowel sounds -> Hyperactive: SYMPATHOMIMETIC -> Hypoactive: ANTICHOLINERGIC -> Normal or Low -> Bowel sounds -> Hyperactive: HALLOCUNOGENIC -> Hypoactive: SEDATIVE-HYPNOTICS Anticholinergic Toxidrome and the Physostigmine antidote: • Anticholinergics inhibit the binding of acetylcholine to the muscarinic receptors in the central nervous system and the parasympathetic nervous system. Examples of anticholinergics include atropine and tiotropium. Other substances that may cause anticholinergic toxidrome include antihistamines (especially first-generation: diphenhydramine), antipsychotics (quetiapine), antidepressants (TCAs, paroxetine), and antiparkinsonian drugs (benztropine). Symptoms of toxicity include tachycardia, non-reactive mydriasis, anhidrosis, dry mucous membranes, skin flushing, decreased bowel sounds, and urinary retention. Neurological symptoms include delirium, confusion, anxiety, agitation, mumbling, visual hallucination, and strange behavior. Neurological symptoms last longer because of the anticholinergic lipophilic properties which cause them to distribute into fatty organs and tissues like the brain. “Mad as a hatter, red as a beet, blind as a bat, hot as a hare, dry as a bone” [Spanish: loco como una cabra, rojo como un tomate, ciego como un topo, seco como una piedra, caliente como el infierno] • The antidote for anticholinergic toxidrome is physostigmine. It is an acetylcholinesterase inhibitor and prevents the metabolism of acetylcholine. This increases the level of acetylcholine in both the central nervous system and peripheral nervous system. Physostigmine can cause seizures and arrhythmia, so close monitoring in the hospital is required during treatment. Cholinergic toxidrome and its antidotes atropine and pralidoxime: Acetylcholine is part of the parasympathetic nervous system and cholinergic substances can induce a parasympathetic response. Some of these substances include pesticides, organophosphates, carbamate, and nerve gas. Chlorpyrifos had been used to control insects in homes and fields since 1965. It has been used in our crops in Bakersfield, and the most recent mass exposure was in May 2017. it was banned on food crops in the US in August 2021. It has been banned for residential use for a longer period. Repeated exposure to chlorpyrifos causes autoimmune disorders and developmental delays in children and fetuses. The symptoms of cholinergic toxidrome can be summarized with the SLUDGE/ “triple” BBB acronym. This includes salivation, lacrimation, urination, defecation, gastrointestinal cramping, emesis, bradycardia, bronchorrhea, and bronchospasm. There can also be muscle fasciculations and paralysis. • The antidote is Atropine. Pralidoxime is used for organophosphates only because it cleaves the organophosphate-acetylcholinesterase complex to release the enzyme to degrade acetylcholine. Pralidoxime should be used in combination with atropine, not as monotherapy. It requires hospital admission, and a note for organophosphate, remember that the patient needs external decontamination (shower). Let's go to part 2 of our discussion, environmental exposure. Carbon Monoxide Toxidrome and the antidote oxygen: Carbon monoxide intoxication is usually due to smoke inhalation injury. Carbon monoxide is a silent gas produced by carbon-containing fuel or charcoal. Carboxyhemoglobin (COHb) forms in red blood cells when hemoglobin combines with carbon monoxide, reducing the binding and availability of oxygen at the tissue level. It's like CO falls in love with hemoglobin and hemoglobin cheats on Oxygen by binding to CO instead, and neglects oxygen delivery to tissues. Carbon monoxide also causes direct cellular toxicity. The symptoms and signs of poisoning include headache, altered mental status, nausea, vomiting, visual disturbance, Cherry-red lips, coma, and seizure. You can also see lactic acidosis and pulmonary edema. Neurological symptoms can be chronic, so it's important to follow up. The blood COHb level must be used to confirm the diagnosis because standard pulse oximetry (SpO2) and arterial partial oxygen pressure (PaO2) cannot differentiate COHb from normal oxygenated hemoglobin. You must obtain a serum COHb level. • The antidote is 100% oxygen or hyperbaric oxygen therapy and close follow-up. Consider intubating if there is edema of the airways due to inhalation injury. Cyanide Toxidrome which include sodium nitrite, sodium thiosulfate, and hydroxocobalamin In combination with Carbon Monoxide poisoning Cyanide poisoning can simultaneously be caused by inhalation of smoke or colorless hydrogen cyanide or ingestion of cyanide salts or prolonged use of sodium nitroprusside (ICU for hypertensive emergency). Symptoms are very similar to carbon monoxide poisoning. There may be long-term neurologic deficits and Parkinsonism. Diagnosis is clinical and waiting for serum cyanide levels can cause treatment delay. However, serum lactate levels over 10 mmol/L suggest cyanide poisoning. • Since cyanide poisoning resembles carbon monoxide poisoning and both toxidromes typically present simultaneously in the pathognomonic fire victim, treat simultaneously with sodium nitrite, sodium thiosulfate, and hydroxocobalamin as well as oxygen as mentioned with carbon monoxide poisoning. Hypnotic and sedative substances (antidote: flumazenil) Examples of hypnotic or sedative substances are alcohol, benzodiazepines, or zolpidem. Signs and symptoms of toxicity include slurred speech, ataxia, incoordination, disorientation, stupor, and coma with mild and rare hypoventilation and bradycardia. • The antidote is flumazenil which is a competitive antagonist at the benzodiazepine receptor. After treatment monitor patients for seizures in case of TCA poisoning, arrhythmia, or epilepsy. Opioid toxidrome (antidote: naloxone) Examples of opioid intoxication in children would be heroine in adolescents or accidental ingestion of pain medication in young children. Signs and symptoms are similar to the sedative toxidrome except for the pathognomonic finding of miosis or “pinpoint pupils” on physical exam. There will also be respiratory depression, hyporeflexia, bradycardia, muscle rigidity, and absent bowel sounds or constipation. Hypoventilation is severe and can cause death. • The antidote is naloxone which is a synthetic opioid receptor antagonist that can diagnose and treat opioid poisoning. It is indicated if the respiratory rate is less than 12. It has a short half-life and is repeatedly administered every 3-5 minutes until the respiratory drive is restored in order to avoid rebound respiratory depression and intubation. It has a rapid onset so the patient must be observed for 24 hours for opioid withdrawal symptoms. Summary: It is important to be able to recognize a toxidrome and antidote early. Once the antidote is administered, you should observe the patient 24 hours for symptoms of rebound toxicity or withdrawal. Consider repeat administration of the antidote if rebound symptoms occur and treat withdrawal symptoms as needed. Don't forget to consider multidrug poisoning if symptoms are non-specific. Thank you for having me on your podcast to review this topic. ____________________________ Conclusion: Now we conclude our episode number 108, “Antidotes to Toxidromes.” Remember you can start treatment of a patient with typical signs and symptoms of specific toxidromes, especially in patients who are unstable. We hope you enjoyed this episode. We thank Hector Arreaza, Aida Francis, and Arianna Lundquist. Audio Edition by Adrianne Silva. Even without trying you go to bed being a little wiser. Thanks for listening to Rio Bravo qWeek Podcast. If you have any feedback, contact us by email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week! _____________________ References: 1) Jaelkoury, CC BY-SA 3.0 , via Wikimedia Commons. 2) Hon KL, Hui WF, Leung AK. Antidotes for childhood toxidromes. Drugs Context. 2021;10:2020 11-4. Published 2021 Jun 2. doi:10.7573/dic.2020-11-4, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177957/. 3) Royalty-free music used for this episode: Space Orbit by Scott Holmes, downloaded on July 20, 2022 from https://freemusicarchive.org/music/Scott_Holmes/.

You must listen to this podcast and learn how certain supplements have the ability to enhance our brain health even as we age. Take advantage of an exclusive podcast offer today by visiting http://www.invitehealth.com/podcast. For more information on the products or studies mentioned in this episode, as well as a complete transcript of the audio, click here

A cholinergic crisis can occur if the body stops properly breaking down Acetylcholine. This can cause overactivity of Acetylcholine at the neuromuscular junction. Acetylcholine is part of Rest & Digest (Parasympathetic) – so we see overactive digestion and secretion.

There are eight B-vitamins that benefits overall health, including keeping your nerves healthy. But three of these vitamins – Thiamine (B1), Pyridoxine (B6), and Cobalamin (B12) are mainly known to support nervous system function. Continue reading to find out how these three B-complex vitamins help support your nervous system and keep it in tip-top shape. Thiamine (B1) Vitamin B1 has a huge benefit to your central nervous system (CNS). This vitamin aids the synthesis of acetylcholine, which is one of the most abundant neurotransmitters in your CNS. This chemical helps to relay messages from your brain to your body muscles, thereby influencing movement and behavior. Acetylcholine also helps memory and cognitive function. More so, it plays a role in regulation of hormones, learning, sleep cycles, and pain sensation. Now, imagine if your body is not producing enough of acetylcholine because you're having vitamin B1 deficiency. You'll not only experience fatigue, but you'll suffer poor short-term memory and confusion. Your feet and hands may become numb and your movement hampered. So ensure you're getting enough of vitamin B1 in your diet. Some thiamine-rich foods you can include in your diet include beans, nuts and seeds, beef, yeast, liver, oranges, eggs, pork, peas, legumes, and oranges. Pyridoxine (B6) While thiamine is essential for the synthesis of acetylcholine, pyridoxine is needed in the synthesis of other neurotransmitters like norepinephrine and serotonin. Norepinephrine is the stress hormone helpful in triggering a fight-or-flight response. This neurotransmitter helps increase the amount of oxygen in your brain, helping you to think and make decisions faster. Serotonin is an import neurotransmitter responsible for regulating your appetite, mood, and sexual desire. It also helps to enhance your memory and maintain your sleep cycle. Vitamin B6 also plays an important role in myelin formation – the insulating sheath around your nerves. This helps in quick and efficient transmission of electrical impulses along your nerves. When you're deficient in vitamin B6, you tend to feel more tired, irritable, nervous, and depression. This vitamin deficiency is also linked with conditions such as neuritis, neuralgia, and carpal tunnel syndrome. So it is important to add pyridoxine-rich foods to your diet. Some good options including meat, legumes, bananas, avocados, fish, tofu, soybean, and potatoes. Cobalamin (B12) Both vitamin B6 and B12 are needed for maintaining your myelin. Cobalamin helps in the synthesis of myelin that protects the nerves. If myelin becomes damaged, it can lead to dysfunctional nerves, which leads to problems such as peripheral neuropathy. Pregnant women who do not eat foods rich in cobalamin puts their babies at risk of nervous system disorders like seizures, brain atrophy, microencephaly, and even blindness. Some good food options that are rich in vitamin B12 include read meat, fish, poultry, eggs, lamb, liver, fortified yeast products, and milk. Looking at these benefits of the B-complex vitamins for your nervous health, it is important that you get enough of these vitamins from your diet or take supplements (as approved by your doctor). If you're going to load up on B vitamin supplements, ensure you choose options with optimum combination of the B vitamins to prevent running into deficiency in any form. You can consult Dr. Jason Jones at our chiropractic office in Elizabeth City, NC, to learn more about how vitamins support your nervous system and other bodily functions.

Huberman Lab Podcast Notes Key Takeaways Adequate quality and duration of sleep and experiencing all the different stages of sleep (i.e., slow wave, REM) are important in optimizing metabolic circuits for health and performanceWhen done properly (i.e., sleeping and waking at roughly the same time, bright light exposure in the morning, dim lights in the evening, etc.) study participants experienced huge benefits in mood, stress, and grip strength (among other outcomes) when switching habits from “night owl” to “morning person”Four main neuromodulators: (1) dopamine; (2) epinephrine/adrenaline; (3) serotonin; (4) acetylcholineDifferent neuromodulators are naturally present at higher or lower levels in each phase of the day – leverage these natural fluctuations to optimize your focus and outcomes“Dopamine is not about pleasure, it's about motivation, craving, and pursuit for goals or things outside our immediate experience or possession.” – Dr. Andrew HubermanTools optimize dopamine: sunlight, caffeine, tyrosine, mucuna pruriens, L-tyrosine, phenylehtylamine, cold exposure, B vitaminsTools to optimize epinephrine: exercise, breathwork (cyclic hyperventilation), caffeineTools to optimize acetylcholine: foods rich in choline, nicotine (no, don't smoke cigarettes), alpha-GPC, huperzine, narrow visual fieldTools to optimize serotonin: physical touch, gratitude, tryptophan, cissus quadrangularis, 5-HTP, myo-inositolWhen trying any of the tools listed, start with the behavioral approach, then nutrition, then supplementation, then turn to the clinical/pharmaceutical approach if all else fails or there is a medical necessityRead the full notes @ podcastnotes.orgIn this episode, I explain the biological roles of the four major neuromodulators—dopamine, epinephrine (aka adrenaline), serotonin, and acetylcholine—and describe how these neuromodulators impact a wide variety of mental states and behaviors, including focus, creativity, motivation, drive, learning, alertness, mood, relationships, and feelings of well-being. Then, with that foundational understanding in mind, I describe a potent toolkit of science-supported behavioral, nutrition, and supplementation tools that can be used to increase baseline levels of individual neuromodulators and that can be modified for specific goals. This episode summarizes low-or-no-cost, actionable, science-based tools that can benefit anyone in order to enhance their levels of brain chemicals and improve mental health, physical health, and performance. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman Thesis: https://takethesis.com/huberman InsideTracker: https://insidetracker.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman. For the full show notes, visit hubermanlab.com. Timestamps (00:00:00) Optimizing Neurochemicals to Improve Health (00:03:40) Momentous Supplements (00:05:30) Sleep & Maintaining Healthy Metabolism (00:09:52) Tools: How to Wake Up Earlier, Night Owls (00:19:32) AG1 (Athletic Greens), Thesis, InsideTracker (00:22:05) Nervous System Overview (00:31:32) How Neuromodulators Work   (00:34:24) Baseline Neuromodulator Levels, 3 Daily Phases (00:42:15) Hormones Modulate Neuromodulators (00:52:12) The 4 Major Types of Neuromodulators (01:01:45) Tool Kit 1: Increase Baseline Dopamine & Focus (01:08:52) Tyrosine-rich Foods & Dopamine (01:10:59) Dopamine Supplementation: Mucuna Pruriens, L-tyrosine & Phenylethylamine (01:16:00) Deliberate Cold Exposure & Dopamine (01:21:12) Tool Kit 2: Additional Tips to Increase Dopamine (01:26:10) Tool Kit 3: Increase Epinephrine (Adrenaline) & Alertness (01:34:34) Tool Kit 4: Increase Acetylcholine & Attention/Learning; Choline-rich Foods (01:37:29) Acetylcholine Supplements: Nicotine, Alpha GPC, Huperzine   (01:44:47) Tool Kit 5: Behavior to Increase Focus & Acetylcholine (01:46:56) Tool Kit 6: Behavior to Increase Serotonin & Feelings of Well-being   (01:50:51) Tools: Tryptophan-Rich Foods & Serotonin (01:53:31) Tools: Serotonin Supplements: Cissus Quadrangularis, 5-HTP, Myo-inositol (02:02:14) Use the Neurochemical Toolkit to Meet Individual Goals (02:06:44) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Instagram, Twitter, Neural Network Newsletter Title Card Photo Credit: Mike Blabac Disclaimer

In this episode, I explain the biological roles of the four major neuromodulators—dopamine, epinephrine (aka adrenaline), serotonin, and acetylcholine—and describe how these neuromodulators impact a wide variety of mental states and behaviors, including focus, creativity, motivation, drive, learning, alertness, mood, relationships, and feelings of well-being. Then, with that foundational understanding in mind, I describe a potent toolkit of science-supported behavioral, nutrition, and supplementation tools that can be used to increase baseline levels of individual neuromodulators and that can be modified for specific goals. This episode summarizes low-or-no-cost, actionable, science-based tools that can benefit anyone in order to enhance their levels of brain chemicals and improve mental health, physical health, and performance. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman Thesis: https://takethesis.com/huberman InsideTracker: https://insidetracker.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman. For the full show notes, visit hubermanlab.com. Timestamps (00:00:00) Optimizing Neurochemicals to Improve Health (00:03:40) Momentous Supplements (00:05:30) Sleep & Maintaining Healthy Metabolism (00:09:52) Tools: How to Wake Up Earlier, Night Owls (00:19:32) AG1 (Athletic Greens), Thesis, InsideTracker (00:22:05) Nervous System Overview (00:31:32) How Neuromodulators Work   (00:34:24) Baseline Neuromodulator Levels, 3 Daily Phases (00:42:15) Hormones Modulate Neuromodulators (00:52:12) The 4 Major Types of Neuromodulators (01:01:45) Tool Kit 1: Increase Baseline Dopamine & Focus (01:08:52) Tyrosine-rich Foods & Dopamine (01:10:59) Dopamine Supplementation: Mucuna Pruriens, L-tyrosine & Phenylethylamine (01:16:00) Deliberate Cold Exposure & Dopamine (01:21:12) Tool Kit 2: Additional Tips to Increase Dopamine (01:26:10) Tool Kit 3: Increase Epinephrine (Adrenaline) & Alertness (01:34:34) Tool Kit 4: Increase Acetylcholine & Attention/Learning; Choline-rich Foods (01:37:29) Acetylcholine Supplements: Nicotine, Alpha GPC, Huperzine   (01:44:47) Tool Kit 5: Behavior to Increase Focus & Acetylcholine (01:46:56) Tool Kit 6: Behavior to Increase Serotonin & Feelings of Well-being   (01:50:51) Tools: Tryptophan-Rich Foods & Serotonin (01:53:31) Tools: Serotonin Supplements: Cissus Quadrangularis, 5-HTP, Myo-inositol (02:02:14) Use the Neurochemical Toolkit to Meet Individual Goals (02:06:44) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Instagram, Twitter, Neural Network Newsletter Title Card Photo Credit: Mike Blabac Disclaimer

GABA is an important neurotransmitter you don't hear about much. Learning of my own low GABA symptoms changed my life – I should say saved my life Is GABA Similar to Serotonin? GABA is Gamma-Aminobutyric Acid. Along with Serotonin, these neurotransmitters provide the “brakes” to overstimulated nerve impulses. Keeping the brain relaxed but on purpose is their job. Dopamine, Adrenaline, Acetylcholine, and anxiety are emotional, hormonal and neurological stimulants. They set off a chain reaction of stress, causing interference all over the body. When our brakes are inadequate to the task, we suffer from imbalanced neurotransmitters and hormones. more information...

In todays episode, I will share some natural approaches to getting better sleep without compromising your health. One of the most common sleep aids is diphenhydramine (also known as Benadryl or Unisom brand names). Diphenhydramine works by blocking histamine activity as well as acetylcholine activity which provokes a drowsy state. Acetylcholine is like a nerve cell manager and when its activity is shut off, the coordination between neurons and the ability to file memories and information in an orderly fashion to be retrieved easily at a moments notice is broken. Now consuming a diphenhydramine-based drug occasionally every 3-6 months isnt likely to have any negative long term implications. However, taken regularly, it can spell disaster for your cognition and memory.

Commentary by Dr. Valentin Fuster

Whether you're new to the gym, an everyday athlete, or a pro at lifting weights, chances are you have heard of, tried, or religiously take pre-workout. With a forever-growing list of pre-workout formulas, how do you choose the best one for you and your fitness goals? In today's episode of the ATP project, Jeff and Steve get nitty-gritty talking about the science behind the best pre-workout ingredients and which ones you should look for depending on your goals.  The team discusses the categories and functions of pre-workouts if becoming desensitised to caffeine is really a myth, as well as the reasons as to why Saffron, Carnitine, Beta-alanine, Acetylcholine, Tyrosine, Alpha GPC, and Huperzine-A may be beneficial in a pre-workout. Whether you're looking for a pump, increased performance, more muscle strength, or focus, this episode will be for you As always, this information is not designed to diagnose, treat, prevent or cure any condition and is for information purposes only - please discuss any information in this podcast with your health care professional before making any changes to your current lifestyle.   Check out ATP Science's range of products at our online store - https://bit.ly/3vIDr9z

Welcome to Balance and Moderation… A Wellness podcast, with some personality… Big love is the motto and our message is for everyone, so don't forget to share this with all the beautiful people in your life. Enjoy! The ability to focus is becoming more and more difficult with the rise of technology. This has caused people to become addicted to caffeine and Adderall in order to achieve success in the modern world. In the long run this addiction with lead to physical and mental health issues and should be avoided at all cost. Luckily Episode 48 of The BAM Podcast is here with some great information on natural and healthy ways to stay focused and productive. Please rate and review us on Apple Podcasts if you haven't already! Check out our Instagram @theBAMpodcast Send any questions and inquiries you have to balance.moderation@gmail.com Hosts: Sheridan Lee @TheSoulAndScience Rob Young @WellnessRob Show notes: Supplements B12 – cofactor: converts food into energy; decreases with stress; regulates immune system Most bioavailable in liver & animal sources Creatine – replenishes ATP/ADP balance for physical & mental stamina Ashwaganda – adaptogenic, promotes heart & lung function (oxygen, circulation = energy production), supports adrenal function – reduces anxiety & stress response Vitamin D – SUNLIGHT, critical nutrient for mitochondrial function, immune regulator Magnesium – cofactor for energy production, one of the top nutrient deficiencies around the world CoQ10 – used in mitochondria to create energy, also an antioxidant (protects mitochondria from stress, damage, etc) Rhodiola – NEUROPROTECTIVE, helps brain create more serotonin, dopamine, norepinephrine = high energy, focus, clarity, brain power (nootropic) Ginseng – opens blood vessels in the brain, more oxygen and nutrients to the brain; aids adrenal health & function Acetylcholine – provides choline molecule needed for building brain tissue, prominent NT in brain, found in high concentration in eggs Alpha Lipoic Acid (ALA) – found in cell's mitochondria, antioxidant Additonal Supps/Info Stress damages mitochondrial cells, which create energy – so supplementing body with mitochondrial cofactors and stress modulators helps create more energy in the body Breakfast – protein & fiber – helps prevent blood sugar / energy crash mid-day Peppermint gum – mastication (chewing) helps increase HR → increase energy; peppermint invigorating & refreshing Aromatherapy / Oils – citrus & mint oils are stimulating, invigorating, and can help with alertness & focus; homemade Focus Blend – peppermint, wild orange, basil (adrenal support) & frankincense (vasodilator in brain tissue) Techniques / Tools Pomodoro Timer: 25 minutes on, 5 min break Getting high quality sleep Brain dump: take 10 min to write down everything that is on your mind and get it out of your head, able to discern emotions from information & determine what is actually important/urgent and what is “fluff” Using a planner, write down top 3 tasks for the day and make sure they get accomplished

Our Neuropsychologists, Dr. Laura Jansons Dr. Skip Hrin, AND Neurofeedback legend Jay Gunkelman review and discuss: The Surgeon General's Warning Report re: Mental Health of our Children The Death of 33-year-old former NFL Wide Receiver Demaryius Thomas from SUDEP "Signal In the Noise" the Documentary about our own Jay Gunkelman Sleep Hygiene See bottom of the page for the plethora of links discussed today We thank our Patreon Supporters: https://www.patreon.com/NeuroNoodleFeatured Business: Outrageous Baking, Tor Talk, Joshua M of Alternative Brain Therapy, and MARA https://www.outrageousbaking.com/ https://tortalk.se/?lang=en https://neurofeedbackcare.com/ "EEG and Me". "Sandhya M", "Johnathan January-Turrall", "Rowan January-Turrall" Have an idea for a topic or guest? pete@neuronoodle.com Jansons.com DrSkipHrin.com Some of the Links Discussed in the show: (go easy on Pete its hard to keep up with Jay) https://www.nanonline.org/nan/ https://nanonline.org/nan/Education_Events/Annual_Conference/NAN/_ContinuingEducation/_Conference/2021_DC/2021_Conference.aspx?hkey=e4c298c1-b18c-4323-af16-9679f933ba64 https://en.wikipedia.org/wiki/Acetylcholine https://www.health.harvard.edu/blog/common-anticholinergic-drugs-like-benadryl-linked-increased-dementia-risk-201501287667 https://en.wikipedia.org/wiki/Suprachiasmatic_nucleus https://www.sleepfoundation.org/circadian-rhythm-sleep-disorders#:~:text=A%20delayed%20circadian%20rhythm%20can,an%20early%20wake%2Dup%20time. https://www.epilepsy.org.uk/info/syndromes/electrical-status-epilepticus-during-slow-wave-sleep-esess https://www.healthline.com/health/epilepsy/intractable-epilepsy#what-is-it https://www.gofundme.com/f/the-release-of-the-gunkelmentary https://www.stens-biofeedback.com/mary-tracy https://www.imdb.com/title/tt13181022/ https://www.bfi.org.uk/ https://fargofilmfestival.org/index.php/about/ https://www.rehobothfilm.com/event/festival/ --- Send in a voice message: https://anchor.fm/neuronoodle/message Support this podcast: https://anchor.fm/neuronoodle/support