Podcasts about splicing

Tâm is the first listener-suggested guest, thanks to regular listener, Brandon Coleman. Tâm is an entertaining and interesting guest that has an in-depth story and many insights to share about life in Saigon, which can be seen by the length of this episode. Born in Texas to Vietnamese refugees, Tâm moved to Saigon after a stint in Singapore. Here in Saigon she worked at an international branding agency but soon started creating Vietnamese-Mexican dishes and hosting dinners out of her apartment, creating a closed-door restaurant named Saigonita. Soon Saigonita appeared in Vice Munchies and was profiled in Saigoneer so she decided to quit her corporate career to pursue her passion in food. Since then, she's been interviewed by publications in Vietnam, Singapore, the US, Italy, France; and has given a TEDx Talk. She is currently getting to more deeply know her roots and explore Vietnam's culinary scene through travels around the country.-------------------Theme music composed by Lewis Wright.Main Cover Art designed by Niall Mackay and Le Nguyen.Episode art designed by Niall Mackay, with pictures supplied by guests and used with permission."Send me a message!"Support the show

In this special episode, recorded live at the 2025 Genomics England Research Summit, host Adam Clatworthy is joined by parents, clinicians and researchers to explore the long, uncertain and often emotional journey to a genetic diagnosis. Together, they go behind the science to share what it means to live with uncertainty, how results like variants of uncertain significance (VUS) are experienced by families, and why communication and support matter just as much as genomic testing and research. The panel discuss the challenges families face when a diagnosis remains out of reach, the role of research in refining and revisiting results over time, and how collaboration between researchers, clinicians and participants could help shorten diagnostic journeys in the future. Joining Adam Clatworthy, Vice-Chair for the Participant Panel, on this episode are: Emma Baple – Clinical geneticist and Medical Director, South West Genomic Laboratory Hub  Jamie Ellingford – Lead genomic data scientist, Genomics England  Jo Wright – Member of the Participant Panel and Parent Representative for SWAN UK  Lisa Beaton - Member of the Participant Panel and Parent Representative for SWAN UK  Linked below are the episodes mentioned in the episode:  What is the diagnostic odyssey?  What is a Variant of Uncertain Significance?  Visit the Genomics England Research Summit website, to get your ticket to this years event. You can download the transcript, or read it below. Sharon: Hello, and welcome to Behind the Genes. My name is Sharon Jones and today we're bringing you a special episode recorded live from our Research Summit held in June this year. The episode features a panel conversation hosted by Adam Clatworthy, Vice-Chair of the Participant Panel. Our guests explore navigating the diagnostic odyssey, the often-complex journey to reaching a genetic diagnosis. If you'd like to know more about what the diagnostic odyssey is, check our bitesize explainer episode, ‘What is the Diagnostic Odyssey?' linked in the episode description. In today's episode you may hear our guests refer to ‘VUS' which stands for a variant of uncertain significance. This is when a genetic variant is identified, but its precise impact is not yet known. You can learn more about these in another one of our explainer episodes, “What is a Variant of Uncertain Significance?” And now over to Adam. -- Adam: Welcome, everyone, thanks for joining this session. I'm always really humbled by the lived experiences and the journeys behind the stories that we talk about at these conferences, so I'm really delighted to be hosting this panel session. It's taking us behind the science, it's really focusing on the people behind the data and the lived experiences of all the individuals and the families who are really navigating this system, trying to find answers and really aiming to get a diagnosis – that has to be the end goal. We know it's not the silver bullet, but it has to be the goal so that everyone can get that diagnosis and get that clarity and what this means for their medical care moving forwards.    So, today we're really going to aim to demystify what this diagnostic odyssey is, challenging the way researchers and clinicians often discuss long diagnostic journeys, and we'll really talk about the vital importance of research in improving diagnoses, discussing the challenges that limit the impact of emerging research for families on this odyssey and the opportunities for progress. So, we've got an amazing panel here. Rather than me trying to introduce you, I think it's great if you could just introduce yourselves, and Lisa, I'll start with you. Lisa: Hi, I'm Lisa Beaton and I am the parent of a child with an unknown, thought to be neuromuscular, disease. I joined the patient Participant Panel 2 years ago now and I'm also a Parent Representative for SWAN UK, which stands of Syndromes Without A Name. I have 4 children who have all come with unique and wonderful bits and pieces, but it's our daughter who's the most complicated. Adam:  Thank you. Over to you, Jo. Jo:  Hi, I'm Jo Wright, I am the parent of a child with an undiagnosed genetic condition.  So I've got an 11-year-old daughter. 100,000 Genomes gave us a VUS, which we're still trying to find the research for and sort of what I'll talk about in a bit.  And I've also got a younger daughter. I joined the Participant Panel just back in December. I'm also a Parent Rep for SWAN UK, so Lisa and I have known each other for quite a while through that. Adam:  Thank you, Jo.  And, Jamie, you're going to be covering both the research and the clinician side and you kind of wear 2 hats, so, yeah, over to you. Jamie:  Hi, everyone, so I'm Jamie Ellingford and, as Adam alluded to, I'm fortunate and I get to wear 2 hats. So, one of those hats is that I'm Lead Genomic Data Scientist for Rare Disease at Genomics England and so work as part of a really talented team of scientists and engineers to help develop our bioinformatic pipelines, so computational processes. I work as part of a team of scientists and software engineers to develop the computation pipelines that we apply at Genomics England as part of the National Health Service, so the Genomic Medicine Service that families get referred to and recruited to, and we try to develop and improve those. So that's one of my hats. And the second of those is I am a researcher, I'm an academic at the University of Manchester, and there I work really closely with some of the clinical teams in the North West to try and understand a little bit more about the functional impact of genomic variants on kind of how things happen in a cell. So, we can explore a little bit more about that but essentially, it's to provide a little bit more colour as to the impact that that genomic variant is having. Adam: Great, thank you, Jamie. Over to you, Emma. Emma: My name's Emma Baple, I'm an academic clinical geneticist in Exeter but I'm also the Medical Director of the South West genomic laboratory hub, so that's the Exeter and Bristol Genomics Laboratory. And I wear several other hats, including helping NHS England as the National Specialty Advisor for Genomics. Adam: Thank you all for being here. I think it's really important before we get into the questions just to ground ourselves in like those lived experiences that yourself and Jo and going through. So, Lisa, I'm going to start with you. The term ‘diagnostic odyssey' gets bandied around a lot, we hear about it so many times, but how does that reflect your experience that you've been through and what would you like researchers and clinicians to understand about this journey that you're on, essentially? Lisa: So I think ours is less an odyssey and more of a roller-coaster, and I say that because we sort of first started on a genetic journey, as it were, when my daughter was 9 weeks of age and she's now 16½ – the half's very important – and we still have no answers. And we've sort of come a bit backwards to this because when she was 6 months old Great Ormond Street Hospital felt very strongly that they knew exactly what was wrong with her and it was just a case of kind of confirmation by genetics. And then they sent off for a lot of different myasthenia panel genes, all of which came back negative, and so having been told, “Yes, it's definitely a myasthenia, we just need to know which one it is,” at 4 years of age that was removed and it was all of a sudden like, “Yeah, thanks, sorry.” And that was really hard actually because we felt we'd had somewhere to hang our hat and a cohort of people with very similar issues with their children, and then all of a sudden we were told, “No, no, that's not where you belong” and that was a really isolating experience. I can remember sort of saying to the neuromuscular team, “Well is it still neuromuscular in that case?” and there was a lot of shrugging of shoulders, and it just…  We felt like not only had we only just got on board the life raft, then we'd been chucked out, and we didn't even have a floaty. And in many ways I think I have made peace with the fact that we don't have a genetic diagnosis for our daughter but it doesn't get easier in that she has her own questions and my older children – one getting married in August who's already sort of said to me, you know, “Does this have implications for when we have children?”  And those are all questions I can't answer so that's really hard. Adam:  Thank you, Lisa. Yourself, Jo, how would you describe the odyssey that you're currently experiencing? Jo: So my daughter was about one when I started really noticing that she was having regressions. They were kind of there beforehand but, I really noticed them when she was one, and that's when I went to the GP and then got referred to the paediatrician. So initially we had genetic tests for things like Rett syndrome and Angelman syndrome, which they were all negative, and then we got referred on to the tertiary hospital and then went into 100,000 Genomes. So we enrolled in 100,000 Genomes at the beginning of 2017, and we got our results in April of 2020, so obviously that was quite a fraught time. Getting our results was probably not as you would want to do it because it was kind of over the phone and then a random letter. So, what I was told in that letter was that a variant of uncertain significance had been identified and they wanted to do further research to see if it might be more significant. So we were to be enrolled into another research project called Splicing and Disease, which wasn't active at the time because everything had been put on hold for COVID, but eventually we went into that. So, I didn't know what the gene was at that point, when I eventually got the form for going to get her bloods done…  So that went off and then that came back and the geneticist said, “That gives us some indication that it is significant.” So, since that point it's been trying to find more information and research to be able to make it a diagnosis. There have been 2 sort of key things that have happened towards that but we're still not there. So one of the things is that a research paper came out earlier this year so that's kind of a little bit more evidence, it's not going to give us a diagnosis but it kind of, you know, sits there. And the other thing is that my geneticist said, “Actually, yeah, it looks like it's an important change.”  That's as far as we've got. So we've still got work to do to make it a diagnosis or not.  Obviously if it is a diagnosis, it is still a one-of-a-kind diagnosis, so it doesn't give me a group to join or that kind of thing. But now I've got that research paper that I've read and read, and asked ChatGPT to verify that I've understood it right in some places, you know, with the faith that we put into ChatGPT (laughs), I've got a better understanding and I've got something now that I can look back on, the things that happened when my daughter was one, 2, 3, 4 and her development was all over the place and people thought that I was slightly crazy for the things I was saying, that “Actually, no, I can see what's happening.” So, it's like the picture's starting to come into focus but there's work to do. I haven't got a timeframe on that, I don't know when it's going to come together. And I always say that I'm a prolific stalker of the postman; ever since our first genetic tests you're just constantly waiting for the letters to drop through the door. So a diagnostic odyssey to me is just waiting for random events. Adam: I think what you've both kind of really clearly elaborated on is how you're the ones that are having to navigate this journey, you're the ones that are trying to piece this puzzle together, and the amount of time you're investing, all whilst navigating and looking after your child and trying to cope with the daily lived experience as well. And something you've both touched on that I'd love to draw out more is about how exactly was the information shared with you about the lack of diagnosis or the VUS or what's going on, because in our case you get this bit of paper through the post that has all these numbers and it's written in clinical speak and we had no conversation with the geneticist or the doctors. You see this bit of paper and you're reading it, scared for what the future will hold for your child, but I'd love to know like how were you communicated whilst all this is going on, how did you actually find out the next steps or any kind of future guidance. Lisa: So I think in our case we kept sort of going onto neuromuscular appointments, and I think for probably the first 5 years of my daughter's life I kind of had this very naïve thought that every time we turned up to an appointment it would be ‘the one' and then…   I think it would've been really helpful actually in those initial stages if they had said to us, “Actually, we don't know when this is going to happen, if it's even going to happen, you need to kind of prepare yourself for that.” It sounds fairly obvious to say but you don't know what you don't know. And in some ways we were getting genetic test results back for some really quite horrible things and they would tell us, “Oh it's good news, this mitochondrial disorder hasn't come up,” and so part of you is like, “Yay!” but then another part of you is thinking, “Well if it's not that what is it?” And we've very much kind of danced around and still don't really have an answer to whether it's life-limiting. We know it's potentially life-threatening and we have certain protocols, but even that is tricky. We live in North Yorkshire, and our local hospital are amazing. Every time we go in, if it's anything gastro-related, they say to me, “What's the protocol from Great Ormond Street?” and I say, “We don't have one” (laughs) and that always causes some fun. We try to stay out of hospitals as much as we absolutely can and do what we can at home but, equally, there's a point where, you know, we have to be guided by where we're going with her, with the path, and lots of phone calls backwards and forwards, and then is it going to be a transfer down to Great Ormond Street to manage it. And actually the way I found out that nothing had been found from 100,000 Genomes was in a passing conversation when we had been transferred down to Great Ormond Street and we'd been an inpatient for about 6 weeks and the geneticist said to me, “So obviously with you not having a diagnosis from the 100,000 Genomes…” and I said, “Sorry?  Sorry, what was that?  You've had the information back?”  And she said, “Well, yes, did nobody write to you?” and I said, “No, and clearly by my shock and surprise.” And she was a bit taken aback by that, but it happened yet again 2 years later (laughs) when she said, “Well you know everything's been reanalysed” and I said, “No.”  (Laughs)  And, so that's very much, it still feels an awful lot like I'm doing the heavy lifting because we're under lots of different teams and even when they're working at the same hospital they don't talk to each other. And I do understand that they're specialists within their own right, but nobody is really looking at my daughter holistically, and there are things that kind of interrelate across.    And at one of the talks I attended this morning they were talking about the importance of quality of life, and I think that is something that has to be so much more focused on because it's hard enough living without a diagnosis, but when you're living with a bunch of symptoms that, I think the best way I can describe it is at the moment we've got the spokes of the umbrella but we don't have the wrapper, and we don't know where we're going with it. We can't answer her questions, we can't even necessarily know that we're using the most effective treatments and therapies for her, and she's frustrated by that now, being 16, in her own right, as well as we are. And I'm panicking about the navigation towards Adult Services as well because at the minute at least we have a clinical lead in our amazing local paediatrician but of course once we hit and move into that we won't even have him and that's a really scary place to be, I think. Adam: Jo, is there anything you wanted to add on that in terms of how you've been communicated to whilst all this is going on? Jo: Yeah, so I think part of what makes it difficult is if you're across different hospitals because they're not necessarily going to see the same information. So obviously it was a bit of a different time when I got our results, but I got our results on a virtual appointment with a neurologist in one hospital, in the tertiary hospital, and because he could see the screen because it was the same hospital as genetics, and he said, “Oh you've got this” and then the letter came through later. When I had my next appointment with the neurologist in our primary hospital, or secondary care, whatever it's called, in that hospital, he hadn't seen that, so I'm telling him the results, which isn't ideal, but it happens quite a lot. What I think is quite significant to me is the reaction to that VUS.  I have to give it, the doctors that look after my daughter are brilliant, and I'm not criticising them in any way but their reaction to a VUS is “I'm so grateful for the persistence to get to a diagnosis.” Neurologists are a bit more like “Oh it's a VUS so it might be significant, it might be nothing.” Actually, as a patient, as in a parent, you actually want to know is it significant or not, “Do I look at it or not?” And, I mean, like I said, there were no research papers to look at before anyway until a few months ago so I didn't have anything to look at, but I didn't want to look at it either because you don't want to send yourself off down a path. But I think that collective sort of idea that once someone gets a VUS we need a pathway for it, “What do we do with it, what expectation do we set the patients up with and what is the pathway for actually researching further?” because this is where we really need the research. Adam:  Thank you, Jo. So, Emma, over to you in terms of how best do you think clinicians can actually support patients at navigating this odyssey and what's the difference between an initial diagnosis and a final diagnosis and how do you then communicate that effectively to the patients and their family?   Emma: So I think a key thing for me, and it's come up just now again, is that you need to remember as a doctor that the things you say at critical times in a patient's or parent's journeys they will remember – they'll remember it word for word even though you won't – and thinking about how to do that in the most sensitive, empathetic, calm, not rushed way is absolutely key.   And there are some difficulties with that when you're in a very high-pressure environment but it is absolutely crucial, that when you are communicating information about test results, when you're talking about doing the test in the first place, you're consenting the family, you're explaining what you're trying to do and those conditions, you balance how much information you give people.    So, you were talking earlier about “So you haven't got this diagnosis, you haven't got that diagnosis,” I often think it's…  We're often testing for numerous different conditions at the same time, I couldn't even list them all to the parents of the children or the patient that I'm testing. It's key to try and provide enough information without overwhelming people with so much information and information on specific conditions you are just thinking about as a potential.  Sometimes very low down your list actually but you can test for them.    Because people go home and they use the internet and they look things up and they get very, very worried about things. So, for me it's trying to provide bite-sized amounts of information, give it the time it deserves, and support people through that journey, tell them honestly what you think the chance of finding a diagnosis is. If you think it's unlikely or you think you know, sharing that information with family is helpful.   Around uncertainty, I find that a particular challenge. So, I think we've moved from a time when we used to, in this country, declare every variant we identified with an uncertain significance. Now, if we remember that we've all got 5 million variants in our genome, we've all got hundreds and hundreds… thousands and thousands, in fact, of variants of uncertain significance in our genetic code. And actually, unless you think a variant of uncertain significance genuinely does have a probability of being the cause of a child's or a patient's condition, sharing that information can be quite harmful to people.    We did a really interesting survey once when we were writing the guidelines for reporting variants of uncertain significance a few years ago. We asked the laboratories about their view of variants of uncertain significance and we asked the clinicians, and the scientists said, “We report variants of uncertain significance because the clinicians want them” and the clinicians said, “If the labs put the variant of uncertain significance on the report it must be important.” And of course, if you're a parent, if the doctor's told you the variant is a variant of uncertain significance of course you think it's important.    So, we should only be sharing that information, in my opinion, if it genuinely does have a high likelihood of being important and there are things that we can do. And taking people through that journey with you, with the degree of likelihood, the additional tests you need to do and explaining to them whether or not you think you will ever clarify that, is really, really key because it's very often that they become the diagnosis for the family.  Did I cover everything you think's important, both of you?  Lisa: I think the one thing I would say is that when you are patient- or parent-facing, the first time that you deliver that news to the parent… you may have delivered that piece of news multiple times and none of us sit there expecting you to kind of be overcome with emotion or anything like that but, in the same way that perhaps you would've had some nerves when, particularly if it was a diagnosis of something that was unpleasant, you know, to hold onto that kind of humanity and humility. Because for those patients and parents hearing that news, that is the only time they're ever hearing that, and the impact of that, and also, they're going on about with their day, you don't know what else they're doing, what they're juggling.    We're not asking you all to be responsible for kind of, you know, parcelling us up and whatnot but the way information is imparted to us is literally that thing we are all hanging our hats on, and when we're in this kind of uncertainty, from my personal experience I'm uncomfortable, I like to be able to plan, I'm a planner, I'm a researcher, I like to sort of look it up to the nth degree and that, and sitting in a place without any of that is, it's quite a difficult place to be. And it's not necessarily good news for those parents when a test comes back negative, because if it's not that then what is it, and that also leaves you feeling floundering and very isolated at times.  Adam: Yeah, and you touched upon the danger of like giving too much information or pushing families down a particular route, and then you have to pull them out of it when it's not that.   You talked about the experience you had, you felt like you'd found your home and then it's like, “Well, no, no, sorry, actually we don't think it's that.” And you've invested all of your time and your emotion into being part of that group and then you're kind of taken away again. So it's to the point where you have to be really sure before you then communicate to the families, and obviously in the meantime the families are like, “We just need to know something, we need to know,” and it's that real fine line, isn't it?    But, Jamie, over to you. Just thinking about the evolving nature of genomic diagnosis, what role does research play in refining or confirming a diagnosis over time?  Jamie: So it's really, really difficult actually to be able to kind of pinpoint one or 2 things that we could do as a community of researchers to help that journey, but perhaps I could reflect on a couple of things that I've seen happen over time which we think will improve things. And one of that's going back to the discussion that we've just had about how we classify genetic variants. And so, behind that kind of variant of uncertain significance there is a huge amount of effort and emotion from a scientist's side as well because I think many of the scientists, if not all, realise what impact that's going to have on the families.   And what we've tried to do as a community is to make sure that we are reproducible, and if you were to have your data analysed in the North West of England versus the South West that actually you'd come out with the same answer. And in order to do that we need guidance, we need recommendations, we need things that assist the scientists to actually classify those variants.  And so, what we have at the moment is a 5 point scale which ranges from benign to likely benign, variant of uncertain significance, unlikely pathogenic variant and pathogenic variant. It's objective as to how we classify a variant into one of those groups and so it's not just a gut feeling from a scientist, it's kind of recordable measurable evidence that they can provide to assist that classification.   So in many instances what that does is provide some uncertainty, as we've just heard, because it falls into that zone of variant of uncertain significance but what that also does is provide a framework in which we can generate more evidence to be able to classify it in one direction or another to become likely pathogenic or to become likely benign. And as a research community we're equipped with that understanding –– and not always with the tools but that's a developing area – to be able to do more about it.   What that doesn't mean is that if we generate that evidence that it can translate back into the clinic, and actually that's perhaps an area that we should discuss more. But kind of just generating that evidence isn't always enough and being able to have those routes to be able to translate back that into the hands of the clinicians, the clinical scientists, etc, is another challenge. Adam:  And how do you think we can drive progress in research to deliver these answers faster, to really try and shorten those diagnostic journeys, like what are the recommendations that you would say there? Jamie:  So being able to use the Genomics England data that's in the National Genomic Reference Library, as well as kind of other resources, has really transformed what we can do as researchers because it enables teams across the UK, across the world to work with data that otherwise they wouldn't be able to work with.   Behind that there's an infrastructure where if researchers find something which they think is of interest that can be reported back, it can be curated and analysed by teams at Genomics England and, where appropriate, kind of transferred to the clinical teams that have referred that family. And so having that pathway is great but there's still more that we can do about this. You know, it's reliant on things going through a very kind of fixed system and making sure that clinicians don't lose contact with families – you know, people move, they move locations, etc. And so, I think a lot of it is logistical and making sure that the right information can get to the right people, but it all falls under this kind of umbrella of being able to translate those research findings, where appropriate, into clinical reporting.   Adam:  Thank you. And, Emma, is there anything you would add in terms of like any key challenges that you think need to be overcome just to try and shorten the journeys as much as possible and find the answers to get a diagnosis?  Emma: I think trying to bridge that gap between some of the new technologies and new approaches that we've got that we can access in a research context and bringing those into diagnostics is a key area to try to reduce that diagnostic odyssey, so I really want to see the NHS continuing to support those sorts of initiatives.   We're very lucky, as Jamie said, the National Genomic Research Library has been fundamental for being able to reduce the diagnostic odyssey for large numbers of patients, not just in this country but around the world, and so trying to kind of look at how we might add additional data into the NGRL, use other research opportunities that we have in a more synergistic way with diagnostics I think is probably key to being able to do that.    We are very lucky in this country with the infrastructure that we've got and the fact that everything is so joined up. We're able to provide different opportunities in genomics for patients with rare conditions that aren't so available elsewhere in the world.  Adam: Great, thank you. I think we're it for time, so thank you very much to the panel. And I'd just say that if you do have any further questions for ourselves as participants then we're only too happy to pick those up. Thank you for lasting with us ‘til the end of the day and hope to see you soon.  -- Sharon: A huge thank you to our panel, Adam Clatworthy, Emma Baple, Jo Wright, Lisa Beaton and Jamie Ellingford, for sharing their insights and experiences. Each year at the summit, the Behind the Genes stage hosts podcast style conversations, bringing together researchers, clinicians and participants to discuss key topics in genomics.  If you're interested in attending a future Genomics England Research Summit, keep an eye out on our socials. If you'd like to hear more conversations like this, please like and subscribe to Behind the Genes on your favourite podcast app. Thank you for listening.    I've been your host, Sharon Jones. The podcast was edited by Bill Griffin at Ventoux Digital and produced by Deanna Barac.

Van Jensen joins Word Balloon for a wide-ranging conversation about genre, adaptation, and why the best stories don't play it safe. We dig into God Fall, Van's epic, faith-shaking fantasy novel series that's now being developed as a television project by Ron Howard and Imagine. Van breaks down what drew Hollywood to the property, how the story's mix of theology, rebellion, and cosmic war translates to the screen, and what he hopes survives the adaptation intact.From there, we zoom out on Van's knack for genre splicing—stories that take familiar frameworks and twist them into something sharper and stranger. That includes his IDW comic Godzilla: Heist, which turns the King of the Monsters into the centerpiece of a crime caper, and his take on Pinocchio, which leans far closer to the original, darker fairy tale than the softened Disney version most people know. It's a conversation about respecting myth, bending expectations, and trusting readers—and viewers—to follow bold ideas wherever they lead.

First patient treated in Part B of ASTRA trial evaluating SB-007.

Landing on the Moon is no small feat, but with advanced landing technologies, NASA is SPLICE-ing the way for safe, autonomous landings.

As we age, every tissue in the body undergoes gradual molecular changes. A long-standing question in aging research is whether these changes follow common patterns across tissues or whether each tissue ages on its own. While DNA-based “epigenetic clocks” can estimate age accurately across different tissues, identifying consistent patterns in gene expression has been much more challenging. One reason for this difficulty is methodology. Most studies focus on whether genes increase or decrease their expression levels with age. However, genes do not function in isolation. They operate within complex networks, coordinating their activity with many others. Changes in these relationships may be important aspects of the aging process. To understand this, researchers from the University of São Paulo performed a study titled “A combination of differential expression and network connectivity analyses identifies a common set of RNA splicing and processing genes altered with age across human tissues.” Full blog - https://aging-us.org/2026/01/a-common-aging-pattern-changes-in-rna-splicing-and-processing-across-human-tissues/ Paper DOI - https://doi.org/10.18632/aging.206347 Corresponding author - Nadja C. de Souza-Pinto - nadja@iq.usp.br Abstract video - https://www.youtube.com/watch?v=A1slKwaSd6g Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206347 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, gene expression, co-expression network analysis, RNA processing To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@Aging-US LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

BUFFALO, NY — January 5, 2026 — A new #research paper featured as the #cover of Volume 17, Issue 12 of Aging-US was #published on December 22, 2025, titled “A combination of differential expression and network connectivity analyses identifies a common set of RNA splicing and processing genes altered with age across human tissues.” In this study by Caio M.P.F. Batalha from the University of São Paulo, André Fujita from the University of São Paulo and Kyushu University, and Nadja C. de Souza-Pinto also from the University of São Paulo, researchers investigated how gene activity changes with age across multiple human tissues. They found that many tissues share common aging-related alterations in genes involved in RNA splicing and RNA processing. These findings are important because RNA processing is essential for accurate protein production, and disruptions in this process are linked to aging and disease. Aging affects all tissues, yet identifying molecular changes that are shared across the body has remained challenging. To address this, researchers moved beyond traditional approaches that focus exclusively on changes in gene expression levels. They also analyzed how genes alter their patterns of interaction within regulatory networks, capturing age-related changes that are not evident from expression data alone. “Gene expression data (in TPM – transcripts per million) were obtained from the Genotype-Tissue Expression (GTEx) project.” Using RNA sequencing data from nearly one thousand human donors aged 20 to 70, the research team analyzed eight tissues, including blood, brain, heart, skin, and muscle. The results showed that many aging-related changes become evident only when gene network behavior is considered. When gene expression and network connectivity were analyzed together, a consistent group of genes emerged across tissues, most of which were linked to RNA splicing and RNA processing, key steps in the production of functional proteins. The study also revealed that these RNA-related genes are highly interconnected at the protein level. Many of them form known protein complexes, including components of the spliceosome, which plays a central role in RNA maturation. With age, the interactions among these genes tend to reorganize in similar ways across tissues, pointing to a shared biological response rather than independent, tissue-specific effects. In addition to RNA processing, the researchers observed age-related changes in pathways involved in managing damaged RNAs and proteins, including protein degradation, autophagy, and DNA damage response mechanisms. These pathways support cellular quality control and help limit the accumulation of molecular errors that increase with age. Overall, this study identifies RNA splicing and RNA processing as central, conserved features of human aging across tissues. It also demonstrates that network-based approaches provide a more complete view of the aging transcriptome, offering new insights into age-related biological changes and potential directions for aging research. DOI - https://doi.org/10.18632/aging.206347 Corresponding author - Nadja C. de Souza-Pinto - nadja@iq.usp.br Abstract video - https://www.youtube.com/watch?v=A1slKwaSd6g Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@Aging-US LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Dr. Kristen Lynch is a Professor and Chair of Biochemistry and Biophysics at the University of Pennsylvania. Kristen's research focuses on alternative splicing. Her lab is investigating how cells decide when to use an entire portion of the DNA instruction manual versus when to exclude parts of the instructions that are not useful or would be harmful. In particular, Kristen is interested in alternative splicing in the immune system and what happens when cells are faced with an immune challenge. When she's not at work, Kristen loves being outdoors. She spends her free time kayaking, paddle boarding, biking, hiking, and doing yoga. She received her B.A. in biochemistry and her Ph.D. in biochemistry from Harvard University. Afterwards, Kristen pursued postdoctoral training at the University of California, San Francisco. She served on the faculty at the University of Texas Southwestern Medical Center prior to joining the faculty at the University of Pennsylvania in 2009. Kristen is the recipient of many awards and honors for her work, including a National Science Foundation CAREER Award. She joined us for an interview to talk about her experiences in life and science.

Drs. Shipra Agrawal and Monoj K. Das discuss the results of their study, "RNA Alternative Splicing and Polyadenylation and Regulation of the Glomerular Filtration Barrier," with JASN Deputy Editor Alan S.L. Yu and Junior Associate Editor Jason O. Wu.

In this episode of The Crownsmen Show, we sit down with Fenner Dunlop Americas experts Mark Myers and Ronnie Whisenhunt to uncover the hidden risks of conveyor belt failures—and how to prevent them. From catastrophic splices to costly downtime, they reveal why many operations are just one bad splice away from disaster. But there's good news: Fenner Dunlop's cutting-edge finger splicing technology, real-time diagnostics (like Eagle Eye monitoring), and custom splice kits are revolutionizing belt reliability.

In this week's episode we'll learn more about a novel mouse model that recapitulates many of the properties of human sickle cell SC disease; results from the induction phase of the risk-adapted MIDAS trial of isatuximab, carfilzomib, lenalidomide, and dexamethasone in newly diagnosed, transplant-eligible multiple myeloma; and a link between splicing factor mutations and competitive fitness in myelodysplastic syndrome stem cells.Featured articles:A novel mouse model of hemoglobin SC disease reveals mechanisms underlying beneficial effects of hydroxyureaIsatuximab, carfilzomib, lenalidomide, and dexamethasone induction in newly diagnosed myeloma: analysis of the MIDAS trialCell-autonomous dysregulation of interferon signaling drives clonal expansion of SRSF2-mutant MDS stem/progenitor cells

Dr Thomas Cassini explains how the Undiagnosed Diseases Network group used advanced sequencing techniques to clarify the genotype in a child with an unusual phenotype for mitochondrial trifunctional protein deficiency. Mitochondrial trifunctional protein deficiency caused by a deep intronic deletion leading to aberrant splicing Thomas Cassini, et al https://doi.org/10.1002/jmd2.12459

Send us a textThis episode explores the intricacies of fusion splicing and its vital role in fiber optics, featuring insights from expert Jane Bailey. Listeners learn about the advantages of fusion splicing, the importance of cleanliness, safety measures, and practical tips to improve their skills in the field. • Introduction to the importance of fiber optics• Overview of fusion splicing and its advantages• Comparison of fusion splicing and mechanical splicing costs• Evolution of fusion splicing technology and its impact• Core alignment versus cladding alignment explained• Essential tips for effective fusion splicing• Discussion of contamination issues and their resolutions• Importance of safety in fiber optic work• Challenges of inside vs. outside plant splicing• Introduction to spider fiber and its benefits• Insights into OTDR testing and ghosting phenomenaSupport the showKnowledge is power! Make sure to stop by the webpage to buy me a cup of coffee or support the show at https://linktr.ee/letstalkcabling . Also if you would like to be a guest on the show or have a topic for discussion send me an email at chuck@letstalkcabling.com Chuck Bowser RCDD TECH#CBRCDD #RCDD

The company is also planning to conduct the clinical trial at sites in the EU.

The company has also launched a natural history study of patients to inform the planned clinical trial.

- bitcoin passes $0.1M milestone https://truthsocial.com/@realDonaldTrump/posts/113600319916325790 - strike launches bill pay for those of us who are all in bitcoin - trump says he will tariff any countries which leave the dollar https://truthsocial.com/@realDonaldTrump/posts/113573130299319701 - putin says nobody can ban bitcoin https://primal.net/e/note1jvzsqy474l267tf9hrx47e3n2msrxr2nstczevka7zukza2wxdrsphkjvn - Human Rights Foundation Story of the Week China | Prepares for Sanctions While Eyeing Taiwan China is actively studying sanctions imposed on Russia to prepare for potential repercussions if it invades Taiwan. Chinese officials visited Moscow's central bank, finance ministry, and other key agencies to analyze how Russia navigated economic restrictions. This proactive approach speaks to fears China may have over its $3.3 trillion in foreign reserves and overseas bank assets, which would face significant restrictions under Western sanctions. In an effort to mitigate these risks, China is working to diversify away from dollar-denominated assets and reduce reliance on US Treasury bonds, which underpin the global financial system. This comes amid escalating tensions with the US after Washington approved an arms shipment to Taiwan, prompting Beijing to vow “resolute countermeasures.” FinancialFreedomReport.org - BDK Code Audit https://bitcoindevkit.org/blog/_2024-q4-code-audit/ - Eclair v0.11.0: Official Bolt 12 Support, Splicing, Liquidity Ads & On-The-Fly Funding Prototypes https://www.nobsbitcoin.com/eclair-v0-11-0/ - Damus Notedeck Alpha Now Available to Purple Subscribers https://www.nobsbitcoin.com/damus-notedeck-v0-2-0/ - Coinbase says to not use VPNs https://www.nobsbitcoin.com/coinbase-asks-users-to-stop-using-vpns-and-ad-blockers/ - Alex Mashinsky: founder of bankrupt crypto firm to plead guilty to fraud https://www.theguardian.com/technology/2024/dec/03/alex-mashinsky-crypto-fraud-celsius - U.S. Officials Urge Americans to Use Encrypted Messaging Apps https://www.nobsbitcoin.com/u-s-officials-urge-americans-to-use-encrypted-messaging-apps/ - Corporate Transparency Act blocked nationwide by Texas judge https://news.bloombergtax.com/daily-tax-report/corporate-transparency-act-blocked-nationwide-by-texas-court - what bitcoin did relaunches - 1123 days, shoutout to yellow https://x.com/ICOffenderII/status/1864574706583547911 0:00 - Intro 3:52 - Let's gooooooooo 11:57 - Bitstein video 16:30 - Trump says you're welcome 18:15 - Shoutout to Yellow 20:29 - Dashboard 27:15 - Strike launches bill pay 30:47 - Putin bitcoin comment and BRICS talk 38:38 - Healthcare assassination 41:41 - HRF Story of the Week 43:34 - Boosts and Primal/Fountain talk 50:47 - Software updates 57:22 - Coinbase says no vpns 1:00:09 - Mashinsky guilty plea 1:08:15 - Marty failed Barstool 1:11:07 - US officials encourage encrypted comms 1:22:34 - Corp Transparency Act blocked 1:27:22 - WBD relaunch 1:29:40 - Get back to work Shoutout to our sponsors: Unchained https://unchained.com/concierge/ Coinkite https://coinkite.com/ Stakwork https://stakwork.ai/ TFTC Merch is Available: Shop Now https://merch.tftc.io/ Join the TFTC Movement: Main YT Channel https://www.youtube.com/c/TFTC21/videos Clips YT Channel https://www.youtube.com/channel/UCUQcW3jxfQfEUS8kqR5pJtQ Website https://tftc.io/ Twitter https://twitter.com/tftc21 Instagram https://www.instagram.com/tftc.io/ Follow Marty Bent: Twitter https://twitter.com/martybent Newsletter https://tftc.io/martys-bent/ Podcast https://tftc.io/podcasts/ Follow Odell: Nostr https://primal.net/odell Newsletter https://discreetlog.com/ Podcast https://citadeldispatch.com/

Dr. Evan Noch interviews Drs. Nathan Leclair, David Raleigh and Olga Anczukow about their recent manuscript entitled: "RNA splicing as a biomarker and phenotypic driver of meningioma DNA methylation groups", published online in Neuro-Oncology in August 2024.  

Kruw runs the most successful Wasabi wallet 2.0 coordinator and is the kind of privacy advocate who actually builds. In this episode, he talks about continuing Wasabi, the shortcomings of Samourai & how blockchain analysis works. Time stamps: Introduction (00:00:39)
 Recap of Wasabi Wallet Discussions (00:01:33)
 Samourai Wallet's Decentralization Announcement (00:02:28)
 Challenges Faced by Privacy Projects (00:03:56)
 Shift in Bitcoin Culture (00:04:40)
 Impact of Regulatory Pressures (00:05:32)
 Wasabi's Resilience (00:06:40)
 Exploring Bitcoin's Privacy Features (00:07:53)
 Demonstrating CoinJoin Transactions (00:08:36)
 Differences Between CoinJoin and Monero (00:10:24)
 Challenges with Bitcoin Transaction Privacy (00:11:23)
 Concerns Over High Transaction Fees (00:13:11)
 Wasabi's New Features for Privacy (00:17:40)
 User-Friendly Features in Wasabi 2.0 (00:20:14) Transaction Speedup Options (00:21:18)
 Critique of UTXO Management in Wasabi 2.0 (00:23:05)
 Wasabi Wallet User Control (00:23:38)
 Switching Coordinators Feature (00:24:03)
 Decentralized Coordinator Community (00:24:50)
 User Preferences in Coordinator Selection (00:26:18)
 Coordinator Fees Discussion (00:30:56)
 Drivechains and Mining Concerns (00:31:04)
 Market Dynamics of Coordinator Fees (00:34:25)
 Collecting Dust from Transactions (00:37:43)
 Trezor's Coinjoin (00:38:09)
 Wasabi Wallet's Development Funding (00:41:14)
 Samourai Wallet's Blockchain Analysis Tool (00:42:36)
 Address Reuse and Privacy Challenges (00:46:49)
 Mistakes in Privacy Usage (00:49:40)
 Discrediting Wasabi Wallet (00:50:21)
 Cash Fusion (00:51:42)
 Reputation and Arrests (00:53:23)
 Bitcoin Privacy Camps (00:54:33)
 Join Market's Unique Position (00:55:56)
 Legal Risks in Bitcoin Coordination (00:56:21)
 The Fight for Bitcoin's Future (01:00:01)
 Personal Ethics and Legal Protections (01:01:42)
 Concerns Over Martyrdom (01:03:14)
 Physical Tokens and Authenticity (01:04:12)
 Critique of Samourai Wallet (01:05:10)
 Transparency Issues in Samurai Wallet (01:08:09)
 Closed Source vs. Open Source Debate (01:09:55)
 Default Privacy Features in Samurai Wallet (01:11:26)
 Ricochet Transactions and Fees (01:13:13)
 Government Awareness of Transactions (01:14:41)
 Implications of Fee Collection (01:15:01)
 Personal Standards and Hypocrisy (01:15:53)
 New Pepe Avatar Presentation (01:16:21)
 Nostr vs. Twitter (01:18:21)
 Support for CTV & Covenants (01:20:11) Governance and Community Dynamics (01:22:38)
 Concerns about ETF Privacy (01:22:53)
 Complexity of Consensus Changes (01:24:08)
 Community Understanding of Proposals (01:28:20)
 Censorship Resistance in Bitcoin (01:31:01)
 Market Dynamics and Filters (01:32:46)
 Historical Context of Data on Bitcoin (01:34:08)
 Criticism of Jimmy Song (01:35:31)
 Litecoin's Role in Segwit Activation (01:36:30)
 Bitcoin's Cultural Stagnation (01:37:47)
 Ranking Privacy Coins (01:39:45)
 Liquidity vs. Privacy (01:40:26)
 Technological Advancements in Privacy (01:41:39)
 User Resistance to New Technology (01:42:54)
 10101 Shutdown (01:43:09)
 Drivechains and Altcoins (01:44:16)
 Monero Liquidity Concerns (01:45:58)
 Future of Bitcoin vs. Altcoins (01:46:29)
 Cultural Conflicts in Bitcoin Development (01:47:20)
 Blockstream's Influence (01:48:26)
 Whale Bots in Bitcoin (01:51:49)
 Michael Saylor's Influence (01:52:52)
 Bitcoin's Future and Development (01:55:07)
 Censorship Resistance vs. Privacy (01:59:08)
 Satoshi's Coins and Community Reaction (02:00:05)
 Blockchain Analysis Case (02:01:08) Challenges of Privacy Services (02:04:15) Tracking Methods in Blockchain (02:05:20) Understanding Transaction Outputs (02:06:39) Heuristics for Blockchain Analysis (02:09:03) Personal Experience with Blockchain Analysis (02:10:06) Samurai Wallet's Controversies (02:10:58) Victims vs. Heroes in Privacy Projects (02:13:37) Bitcoin Soft Forks for Privacy (02:16:46) Statechains and Privacy (02:18:18) Interactive Transactions Challenges (02:20:08) Monero and Chainalysis (02:22:25) Network Level Privacy Issues (02:23:01) Future of Privacy Tools (02:24:01) Zano's Hybrid Consensus Model (02:24:49) Tail Emission Interest (02:25:13) Consensus Mechanisms Explained (02:26:11) Future of Bitcoin on Layer 2 (02:27:05) Lightning Network, Finally (02:28:28) Privacy Concerns in Lightning (02:29:39) Confidentiality vs. Privacy (02:29:24) Splicing and Lightning Efficiency (02:30:12) Public vs. Unannounced Lightning Channels (02:32:40) Custodial Systems and Privacy (02:34:12) Investment in Privacy Technologies (02:35:31) Nym Security Token Overview (02:36:57) Challenges of Decentralization (02:40:03) Tor and Bitcoin Privacy (02:41:22) Running a Tor Relay (02:42:10) Discussion on Transaction Value (02:48:55) Counterarguments on Spam Incentives (02:49:34) Block Size Debate (02:51:20) Challenges of Block Size Increases (02:52:41) Ethereum vs. Bitcoin Cash (02:57:48) Dynamic Block Size Mechanisms (02:58:57) Running Full Nodes on Mobile (03:00:10) Wrap Up and Future Prospects (03:03:49)

Colletti's first produced feature, which was also his directorial debut, "Safe House," was the official selection of six major film festivals around the world: Slamdance, Slamdance Cannes, Hollywood Black Film Festival, San Francisco Black Film Festival, German Verzanbet Film Festival and Febiofest in Prague.With a film background in editing, Colletti's transition from the editing room to behind the camera has been seamless. He brought with him fifteen years of studio feature film experience, as outlined in his impressive resume.

Genes are recipes for proteins and proteins do stuff. But if a gene can make more than one protein, how does that affect genetic variation and the possible routes to adaptation? We get an introduction to the topic of adaptive alternative splicing from David Manahan. Hosted on Acast. See acast.com/privacy for more information.

The federal government is cracking down on the "broken ice cream machines across fast food chains. A Woman is being charged for commiting Beastiality with her Great Dane & I've unlocked a new fear within myself about Cats. Follow me on Twitter & Instagram: @siddavis Podcast IG: @thesocialintrovertpodcast Podcast Twitter: @SocialintroPod Send emails to: thesocialintrovertpodcastegmail.com Music featured: Intro Song: Monroe Flow - Coolin' Stove God Cools & Stoupe - We Ballin' Again Outro Song: Pip Millett - Better --- Send in a voice message: https://podcasters.spotify.com/pod/show/the-social-introvert/message

Optimization has become an important goal within the electronics assembly industry. While modern electronics assembly techniques utilize a variety of equipment, one specific type of equipment often consumes a disproportionate percentage of the overall equipment budget, that is the place machine. The cost of the machine, associated conveyors and feeders, require that the machine is running as often as possible. The airline industry refers to this as “wheels up” time. Airlines make money when the aircraft is in the air “wheels up.” On the other hand, anytime the wheels are down, the aircraft is not making money for the airline. I listened to an interview a few years ago with the CEO of Southwest Airlines, a US discount carrier. Unlike most other airlines, Southwest does not charge its customers to check bags. The CEO was asked by the reporter why they have not joined the rest of the industry in charging for checked bags. The CEO's answer was genius. If Southwest Airlines began charging for check bags, it would actually slow the boarding process as more and more passengers would drag their bags onto the aircraft, most likely resulting in a number of those bags having to be checked at the gate.  Southwest Airlines is famous for having the fastest aircraft gate turns in the industry, frequently under 30 minutes. Yet, if Southwest Airlines charged for checked baggage, it would require more time at the gate before the next flight would be ready to depart. That would result in fewer flight segments per aircraft per day. In other words, allowing customers to check bags for free equates to more “wheels up” time and, subsequently, more profit for the airline. The same principal can apply to pick-and place machines. When pick-and-place machines are running product, they are making presumably making money. When they sit idle, they are arguably costing money. What can assemblers do to improve the optimization or “wheels up” time on their pick-and-place machines? Mike Konrad's guest, Larry Welk, believes he has an answer. Welk, a.k.a. Professor Splice, is coowner of Smart Splice, a manufacturer of tape splicing tools. Welk reviews tape splicing best practices and explain how tape splicing, when performed correctly, can lead to higher pick-and-place machine optimization. So, buckle your seatbelt: this podcast episode is officially wheels up! Chapters: 00:00:00 - The Importance of Optimization in Electronic Assembly 00:02:34 - Tape Splicing: Best Practices 00:05:12 - Tape Splicing and its Advantages in the Industry 00:07:42 - Continuous Tape Splicing 00:10:10 - Splicing Techniques in Machine Assembly 00:12:31 - Ensuring Quality and Reliability of Tape Splices 00:14:57 - The importance of alignment in splicing 00:17:21 - Types of Tapes and Their Impact on Splicing 00:19:54 - Challenges with Tape Splicing 00:22:09 - Adjusting Feeder Tension 00:24:25 - Splicing and Reel Management in the Industry 00:26:46 - Splicing Parts in the Electronics Industry 00:29:02 - Common Mistakes in Tape Splicing 00:31:34 - Issues with Tape Splicing 00:34:03 - The Crimping Tool and Tape Issues 00:36:25 - The Importance of Switching Techniques 00:38:53 - Improving Production Efficiency through Component Evaluation 00:41:44 - A demonstration of the old tape splicing method 00:44:08 - Splicing Tape Procedure Comparison 00:46:38 - Faster Splicing Technique 00:49:15 - The Negative Experiences with Splicing 00:51:55 - The Benefits of Splicing 00:54:22 - Transitioning from Technician to Salesman 00:56:40 - Conclusion and Farewell  

Optimization has become an important goal within the electronic assembly industry. While modern electronic assembly techniques utilize a variety of equipment, one specific type of equipment often consumes a disproportionate percentage of the overall equipment budget, that is the place machine. The cost of the machine, associated conveyors and feeders, require that the machine is running as often as possible.The airline Industry refers to this as “wheels up” time. Airlines make money when the aircraft is in the air “wheels up”. On the other hand, anytime the wheels are down, the aircraft is not making money for the airline.I listened to an interview a few years ago with the CEO of Southwest Airlines, a US discount carrier. Unlike most other airlines, Southwest does not charge its customers to check bags. The CEO was asked by the reporter why they have not joined the rest of the industry in charging for checked bags. The CEOs answer was genius. If Southwest Airlines began charging for check bags, it would actually slow down the boarding process as more and more passengers would drag their bags onto the aircraft most likely resulting in a number of those bags having to be checked at the gate. Southwest Airlines is famous for having the fastest aircraft gate turns in the industry, frequently under 30 minutes. Yes Southwest airlines charged for checked baggage, it would require more time at the gate before the next flight would be ready to depart. That would result in fewer flight segments per aircraft per day. In other words, allowing customers to check bags for free equates to more “wheels up” time and, subsequently, more profit for the airline.The same principal can apply to pick and place machines. When Pick and machines are running product, they are making presumably making money. When they sit idle, they are arguably costing money. What can assemblers do to improve the optimization or “wheels up” time on their pick and place machines?My guest today, Larry Welk believes he has an answer. Larry Welk, a.k.a. Professor spice is the co-owner of Smart Splice, a manufacturer of tape splicing tools.Larry will review tape splicing best practices and explain how tape splicing, when performed correctly, can lead to higher pick and place machine optimization.So, buckle your seatbelt this podcast episode is officially wheels up!Larry's Contact Information:Larry Welklwelk@smartsplice.comhttps://smartsplice.com/

Prepare to unlock the secrets of fusion splicing as we welcome the incomparable Ron Greenberg from UCL Swift, who shares his treasure trove of knowledge in our comprehensive series. Dispel any intimidation you might feel about this crucial skill; our step-by-step walkthrough and discussion with Ron reveal the simplicity and advancements that have made fusion splicing accessible for technicians everywhere. With the all-in-one fusion splicer as our Excalibur, we cut through the complexities to demonstrate just how manageable and efficient this process has become.Safety goggles on as we navigate the precision and safety that are the heart of fusion splicing in the ICT industry. We're zeroing in on splice loss standards, diving into the equipment technology that meets these stringent requirements, and addressing the safety measures that are non-negotiable in the field. Watch us in action during a live demo with the KF4A all-in-one fusion splicer, a marvel of technology that boasts advanced features to refine the splicing process. Whether you're a seasoned technician or a newcomer eager to learn, this segment will sharpen your skills and give you a clear view of the practicalities of splicing equipment, from battery management to the necessity of a wind cover.Our final narrative arc is tailored for the intrepid field technicians out there, those who splice fibers in the most challenging of environments. Hear tales from the trenches, like splicing in a commercial freezer or the bowels of a coal mine, and the solutions that can turn the tide in your favor. We emphasize maintaining and calibrating your splicing equipment to ensure it's always battle-ready. Plus, Ron and I share insights into promotions that put this critical gear within your reach. We wrap up with a vibrant Q&A session, extending a heartfelt thank you to Ron for his invaluable contributions. Join us for this series, as we connect the world one splice at a time, and don't forget to subscribe for more episodes that empower and inform.Support the showKnowledge is power! Make sure to stop by the webpage to buy me a cup of coffee or support the show at https://linktr.ee/letstalkcabling . Also if you would like to be a guest on the show or have a topic for discussion send me an email at chuck@letstalkcabling.com Chuck Bowser RCDD TECH#CBRCDD #RCDD

In this episode of Bitcoin, Explained, Aaron and Sjors are once more joined by Breez developer Jesse de Wit, this time to explain splicing. Splicing allows users of the Lightning Network to effectively add or remove funds from an active channel, allowing for continuous payment and routing activity. Aaron, Sjors and Jesse discuss what challenges this entails, and how these challenges are overcome. At the beginning of the episode, Sjors also gives a brief update on the ongoing TornadoCash trial in the Netherlands, and he addresses a recent block mined by Mara Pool. === This episode's sponsor: ⁠⁠⁠CoinKite⁠⁠⁠, maker of the ColdCard Jesse's Twitter: ⁠@WitDeJesse⁠ Jesse's Nostr: npub18hwpk5qep3ptnmzatq22ptwr9mth7ccrku56rdntwpxjxlkfyr2qrav8du Aaron's Twitter: ⁠⁠⁠@AaronvanW⁠⁠⁠ Aaron's Nostr: npub1art8cs66ffvnqns5zs5qa9fwlctmusj5lj38j94lv0ulw0j54wjqhpm0w5 Sjors' Twitter: ⁠⁠⁠@provoost⁠⁠⁠ Sjors' Nostr: npub1s6z7hmmx2vud66f3utxd70qem8cwtggx0jgc7gh8pqwz2k8cltuqrdwk4c If you'd like to sponsor the show, please email info at bitcoinexplainedpodcast.com. https://bitcoinexplainedpodcast.com/

Kerry College, in collaboration with Amazon Web Services (AWS) and Sumitomo Electric Lightwave, proudly announces the successful completion of a two-day fibre splicing workshop as part of the Kerry College Open Week 2024. The workshop, held at our Monavalley Campus, catered to both members of the public and current learners engaged in various courses and apprenticeships. Recognised as leaders in optical fibre technologies, AWS and Sumitomo Electric Lightwave joined forces with Kerry College to offer an immersive learning experience focusing on fibre installation and data centre fields. The workshops aimed to raise awareness about skill needs and career prospects in these dynamic and growing sectors. Amazon Web Services (AWS) is the world's most comprehensive and broadly adopted cloud computing provider, offering over 200 fully featured services to clients globally. Millions of customers, including start-ups, large enterprises, and government agencies, are using AWS to lower costs, become more agile, and innovate faster. According to Ms. Joanne Reynolds, AWS Community Engagement Manager, "At AWS in Ireland, we are committed to working with Irish educational institutions to equip graduates with skills for today's economy. This two-day workshop offers a unique pathway for employers to upskill their staff, as well as an option for members of the public to learn invaluable new skills. AWS is delighted to collaborate with Kerry ETB on this project, which will help to enhance the skill base in the region as well as highlighting the career opportunities available to those who enter this sector." The response to the workshop was overwhelmingly positive, with a capacity attendance of 35 learners. Participants were predominantly from the Kerry region, but some learners travelled from as far as Donegal to attend. Additionally, several learners enrolled from local employers, reflecting the workshop's relevance to regional industry needs. Throughout the two-day event, participants delved into the fundamentals of fibre optic installation, repair, and splicing. They also gained hands-on experience by practising real-world deployment techniques, ranging from traditional hand tools to cutting-edge automated fusion splicing technology. Kerry College Monavalley Campus Manager Mr Con O'Sullivan noted, "We are delighted to have had the opportunity to work with AWS and Sumitomo Electric Lightwave and collaborate with them to deliver this unique learning and development opportunity for Kerry." Mr O'Sullivan added, "This is a fantastic programme for those already in the industry who want to develop their skills and knowledge even further, but also for potential career changers who are interested in learning more about this exciting and growing industry." Upon completion of the workshop, Kerry College Monavalley Campus hosted a certificate ceremony, where Kerry ETB Board Chairperson, Cllr. Jim Finucane awarded AWS Certificates of Completion to all successful learners. Councillor Finucane welcomed the initiative and commended AWS, Sumitomo Electric Lightwave and Kerry College for ''delivering relevant, in-demand education and training provision to meet industry needs.' The ceremony was graced by esteemed guests, including Joanne Reynolds, Community Engagement Manager at AWS; Con O'Sullivan, Monavalley Campus Manager; Allyson Eastman, Economic and Workforce Development Manager at AWS; and Lauren Deloatch, Project Manager at Sumitomo Electric Lightwave. This collaborative effort between Kerry College, AWS, and Sumitomo Electric Lightwave underscores a commitment to fostering talent, promoting industry-aligned education, and empowering learners with practical skills essential for future career success. More about Irish Tech News Irish Tech News are Ireland's No. 1 Online Tech Publication and often Ireland's No.1 Tech Podcast too. You can find hundreds of fantastic previous episodes and subscribe using whatever platform you like via our Anchor.fm page he...

I am Jack's 34th minute I start with splicing single frames of pornography into family films and I end with seasoning the lobster bisque at the Pressman hotel. Hosts Bubbawheat and Lance Stanford discuss the David Fincher movie Fight Club one minute at a time. They are joined this week by guest Chris Derkotch. Follow Chris Derkotch: Jay and Silent Bob Minute Follow Bubbawheat: On ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Threads⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Twitter aka X⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Lance: On ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Threads⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Twitter aka X⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Enter to win a copy of Fight Club 2 by sending a screenshot of a podcast review to FightClubMinute@gmail.com Produced by Bubbawheat Member of ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Rabbit Hole Podcasts⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Opening music by the No Corporation

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In this week's episode we'll discuss if fractionated dosing of gemtuzumab ozogamicin provide additional benefit over a single dose in older adults with AML. Then, we'll consider how the loss-of-function of ENT3 drives histiocytosis. Researchers describe a novel pathway leading to histiocytosis that involves hyperactivation of TLR-MAPKinase signaling. This suggests a potential benefit of MAPKinase -directed targeted therapy in a range of histocytoses. Finally we'll discuss unraveling resistance mechanisms to anti-CD20 treatments in B-cell malignancies. Through alternative splicing, the MS4A1 gene encoding human CD20 generates multiple mRNA isoforms with distinct 5' untranslated regions. 

In this week's episode we'll discuss the prognostic significance of splicing factor gene mutations in newly diagnosed AML, learn more about the findings from a multi-omics study of therapy resistance in multiple myeloma, and discuss the effects of KIT ligand deletion on systemic KIT levels and hematopoietic stem cell homeostasis. 

The next generation of Bitcoin Lightning wallets is here with Phoenix from ACINQ. Rejoining me is CTO of ACINQ, Bastien Teinturier to talk about how the team is innovating a great self custodial experience for bitcoin and lightning users: High Fee environment New Phoenix fee structure Splicing and what it enables Dual Funding Liquidity Ads Building on a smartphone app Can ACINQ steal from users?  APO Biggest challenges Reasons to be optimistic Bastien links: Twitter: @realtbast  Phoenix Splicing Update post Sponsors: Pacific Bitcoin Festival (code LIVERA) CoinKite.com (code LIVERA) Mempool.space Stephan Livera links: Follow me on Twitter @stephanlivera Subscribe to the podcast

Chris sits down with Nate from Voltage to talk about the ins and outs of the Lightning Network, ARK, Splicing, and Running a Lightning Node Lower your time preference and lock-in your Bitcoin 2024 and Bitcoin Amsterdam conference tickets today!!! Use promo code BMLIVE for 10% off your tickets! https://b.tc/conference/ Use promo code BMLIVE for 10% off everything in our store! https://store.bitcoinmagazine.com/ IMPORTANT DISCLAIMER "All views expressed by hosts, guests, and interviewees of "Bitcoin Magazine Live" are opinion only and do not reflect the views of Bitcoin Magazine, its ownership, management, any of their associated or affiliated entities, or their inhouse or third party service providers and platforms. This program is informational only, and its content does not contain or construe any offers to buy, sell, or hold any bitcoin, other cryptocurrency, or any securities or other financial instruments in the United States or any other jurisdiction in which such solicitation or offer would be unlawful. Nor does this show's programming constitute any kind of legal, tax, investment, financial, or other advice. Individuals who appear on "Bitcoin Magazine Live" are not deemed investment advisors and their performances in the past are not indicative of future results. Nor are staff or management of "Bitcoin Magazine Live," its publishers and affiliated companies in the business of providing advice, financial or otherwise. All investment carries risk and you should do your own due diligence before investing."

It is important to ask for great things from God, seeking by faith to perceive what God wills to do and by prayers to be involved in his work. - SERMON TRANSCRIPT - Turn in your Bibles to Mark 11. We resume a series now in the Gospel of Mark, and the focus, as you heard in my prayer today, is Mountain-Moving Prayer. On Wednesday, May 30th, 1792, at Friar Lane Baptist Chapel in Nottingham, England, a simple cobbler named William Carey preached one of the greatest sermons in church history. It was later called the Deathless Sermon. It was a call for Christians to make every effort to take the gospel to unreached peoples to the ends of the earth and to the end of time. Up to that point in history, missionaries had usually been Roman Catholic, often Jesuits who are taking Roman power to distant lands, but not the pure gospel. Christians who had rediscovered the gospel through the reformation led by Martin Luther, John Calvin, and others had, up to that point, not really gotten that involved in foreign missions. William Carey would be a pivotal leader in the history of Protestant missions and would himself be part of the solution when he boarded a ship and went to Kolkata, India. William Carey's deathless sermon was broken into two main headings. Number one, expect great things from God, and number two, attempt great things for God. Since that time, at the close of the 18th century, the true gospel has spread to every political nation on earth and the number of genuine Christians all over the world has exploded beyond all boundaries. We don't know how can we know how many are truly born again, but the number may be 500 million, 700 million, a billion, 1.5 billion. We don't know, but it's astonishing. Compared to that, the moving of a physical mountain into the depths of the sea is as nothing. I'm going to take liberties with our brother, William Carey. I don't think he'll mind me adding a third heading to the sermon. I'm not trying to improve on a deathless sermon. How could I? Certainly, we should expect great things from God, but before we can attempt great things for God, I think, based on the text I'm going to preach today, we should ask great things of God. That links the two. Expecting great things, asking great things, attempting great things. I don't think William Carey would mine. Mountain-moving prayer links our expectations, great expectations with great actions. Look at the text, “'Have faith in God.’ Jesus answered. ‘I tell you the truth, if anyone says to this mountain, go throw yourself into the sea, and does not doubt in his heart, but believes that what he has said will happen, it will be done for him. Therefore, I tell you, whatever you ask in prayer, believe that you have received it, and it will be yours.’” The passage is stunning. Jesus uses lavish language to charge his people to ask God to do mighty things and answer to prayer. So let's set the context. I. From a Withered Fig Tree to a Fruitful Church We're moving from a withered fig tree to a fruitful church. It is the last week of Jesus's life. Lots of dramatic moments are happening, beginning with the triumphal entry into Jerusalem. “Hosanna! Hallelujah to the son of David. Blessed it is the coming kingdom of our father, David,” all of that. He goes to the temple, scouts it out. But because it's so late, He goes out of the city to Bethany. The next morning, He goes back in to cleanse the temple, to purify the temple of all that wickedness. En route, He sees this fig tree. Look at verses 12 -14. "The next day, as they were leaving Bethany, Jesus was hungry, seeing in the distance of fig tree and leaf. He went to find out if it had any fruit. When he reached it, he found nothing but leaves because it was not the season for figs. Then he said to the tree, ‘May no one ever eat fruit from you again,’ and his disciples heard him say it.” Now, Jesus' hunger was both physical and prophetical. Jesus represented his father, and this fig tree symbolized Israel. God wanted fruit from Israel from centuries of him pouring out blessings on that nation. But the tree had only leaves, just as Israel had only an appearance of spiritual vitality, but without any genuine fruit in the sight of God. It represented essentially a spiritually dead Israel. So Jesus cursed the tree in a massively significant prophetical action. Prophets did this kind of thing, these kind of symbolic actions. The cursed fig tree died instantly, but not apparently so, not in appearance. Moments after Jesus cursed it, it looked the same. Just like the nation of Israel had leaves and would continue seemingly apparently alive for decades before God finally brought the hammer blow down through the Romans in A.D. 70, destroying the temple. So, immediately after the cursing, it looks fine, but the next morning radically different. The moment Jesus cursed it, it died. But the next morning, it became apparent that that's what had happened. The following morning, Peter noticed and remembered, look at verse 20-21, "In the morning, as they went along, they saw the fig tree withered from the roots. Peter remembered and said to Jesus, ‘Rabbi, look the fig tree, you cursed is withered.’" There's nothing miraculous about a fig tree withering, but there is something miraculous about that happening after powerful words spoken by the son of God, and hours later it looks like it's been dead for years. Now that's a miracle, and the disciples wanted to understand it. In Matthew's Gospel, they asked the question, how did the fig tree wither so quickly? That's the issue. So Jesus at that moment pivots to teach about faith-filled prayer. On the surface, this may seem a bit strange. How did the fig tree wither so quickly? Have faith in God and ask great things in prayer. What's the connection? How do we understand why that lesson at that moment? I think the connection, the link, is fruit. The reason that the fig tree was cursed was fruitlessness. The reason that God would judge Israel was the same fruitlessness. He's about to tell a parable of a vineyard that He's going to give this same lesson on the issue of fruit. In that parable, Jesus speaks of a vineyard planted by an owner. The owner works the soil thoroughly, plants the vines, puts a wall around it, digs out a wine press, and builds a watchtower. Then he rents out the vineyard to some tenant farmers and leaves. But when he sends messengers to collect his share of the fruit, they beat one, kill another, stone a third. Last of all, he sends a son, and they kill him too. In Matthew's telling of that parable, Jesus sums it all up. Matthew 21:43, "Therefore, I tell you, the kingdom of God will be taken away from you." He says to his enemies, "And given to a people who will produce its fruit." Friends, that's us. That's our job. It's given to the church, both Jews and Gentiles, believers in Christ. It's given to us to produce the fruit of the kingdom, and that fruit will only come about by the power of Almighty God, and that expressed in prayer as we pray. I want you to take a minute, put your finger here in Mark, and go over to John 15, and we're going to look at verses 5-8. This is a phenomenal cross-reference. Usually, cross-references are okay, give them a B+ for connection. But this is a top to bottom cross-reference connection here. The lesson of the withered fig tree and the issue of fruitfulness is overtly and clearly taught in John 15:5-8. Look what it says. Jesus said, "I am the vine. You are the branches. If anyone remains in me, and I in him, he'll bear much fruit. Apart from me, you can do nothing. If anyone does not remain in me, he's like a branch that is thrown away and what withers. Such branches are picked up and thrown into the fire, and burned. If you remain in me and my words remain in you, then ask whatever you wish, and it will be given to you. This is to my Father's glory that you bear much fruit, showing yourselves to be my disciples." Surely you must see the points of connection here. It's an agricultural image, that's true, not a fig tree in this case, but a vine with branches. But this goal is the same. It's fruit. A fruitless branch is severed from the vine, thrown to the ground. It withers, and it's thrown to the fire and burned, judgment. Branches that remain in Jesus, people like you and me that stay close to Jesus are intimately connected with him through repentance and faith and are alive in him and stay connected with him. We abide in him. We can pray. If we have God's word saturating our minds, we will know what to pray for. We're not guessing here. God will tell us in his word, what we should pray for, and as we are saturating God's Word, if we remain in him and his words dwell, or abide, or remain in us, then we will ask according to his will, we'll ask whatever we wish, and it will be done for us. In this way, we'll bear the fruit of the kingdom that He talked about. Go back to Mark now, and you see those same lessons. This is a new lesson for his apostles, they were not prayer warriors up to this point. They were not men of prayer. He says in John 16:24, "Until now, you have not asked for anything in my name. Ask and you'll receive, and your joy will be complete." You've not learned this lesson to pray. They're about to be commissioned to go into all the world and be fishers of men, and build the kingdom of God to the ends of the earth. They've got to be men of prayer. So He says in John 14:12-14, "I tell you the truth, anyone who has faith in me will do what I have been doing. He will do even greater things than these because I am going to the Father, and I will do whatever you ask in my name so that the son may bring glory to the Father." You may ask me for anything in my name, and I'll do it. It's prayer. It's prayer. Again and again, it's prayer. There are lots of mountains to be moved from Jerusalem through Judea, and Samaria to the ends of the earth. Lots of mountains had to be moved. People's hearts would have to be changed. The heart of stone removed, the heart of flesh given. People would have to cross over from death to life, and there'd be practical aspects of the spread of the gospel, obstacles that would have to be overcome or moved out of the way. Lots of mountains would have to be moved, and only the Holy Spirit could move them, and He would do it in answer to faith-filled prayer, Mountain-Moving Prayer. That's why Jesus went from the dead fig tree to a lesson on prayer. II. Walking Through Jesus’ Words So let's walk through it now. Let's look at the words. Let's just go step by step through what He says. I'll read them again, beginning at verse 22. "Have faith in God. I tell you the truth, if anyone says to this mountain, go throw yourself into the sea, and does not doubt in his heart but believes that what he has said will happen, it will be done for him. Therefore, I tell you, whatever you ask for in prayer, believe that you have received it, and it will be yours. And when you stand praying, if you hold anything against anyone, forgive him that your Father in heaven may forgive you your sins.” Just walk through it, it begins with the statement, “have faith in God.” Jesus points his disciples to Almighty God as the focus of their lives and especially the focus of their prayer. Focus on God. Faith is the eyesight of the soul, by which you see the invisible God on his throne. Focus on that. Have faith in him. Everything comes from God. For him and through him and to him are all things in his hand is every blessing you want. He opens his hand and satisfies the desires of every living thing. Have faith in the God who can give you what you want, what you need. Have faith in God. Then He says, "Truly, I say to you." Jesus says this from time to time. Everything Jesus said was true, but when he says, “truly, I say to you” or something like that, He's saying, pay attention. Take notice. This is a very important thing I'm about to say to you. Unusually significant, a solemn assertion. Then Jesus says, "If anyone says..." The doctrine He's about to give about prayer is universal; it's for all his followers, not just for the apostles, or for the super spiritual ones, or for the real super leaders, the great William Carey. It's for anyone and everyone. “If anyone says,” basically, in these words, He's going to give three universals. “If anyone says”... so it's any person and then, anything. Whatever you ask in prayer, you'll receive it. Amazing. And then, any unforgiven sin. If you hold anything against anyone, forgive him, these are universals. Sweeping statements “If anyone says.. .” Jesus is expanding our conception of prayer. God is able to immeasurably more than all we ask or imagine. "God is able to immeasurably more than all we ask or imagine. " Then He says, "If anyone says to this mountain, go throw yourself into the sea." Now this should not be taken literally. Some of you have literalistic minds, right? It's like, well, that's it. We believe in errancy, pastor. I do believe in errancy, but I also believe in figures of speech. This is a figure of speech. Jesus did this. He said to the Pharisees, “you strain out a gnat and swallow a camel.” I'm going to stop you right there, you literalist. That never happened. It's a metaphor. You're focused on tiny details, and you're missing the big picture. The mountain represents some massive obstacle to the plan of God. That's what the mountain represents. This mountain, was almost certainly the Mount of Olives, and just so you know from Zechariah 14, God has plans for the Mount of Olives, He doesn't want it moved and thrown into the sea. It's going to be the very place where Jesus will return at the second coming, so let's just leave that mountain right there. In any case, it's a metaphor, and it represents massive obstacles to the plan of God. Then He says, "and does not doubt." Now we get to the issue of doubt. The enemy of faith is doubt. The essence of doubt is questioning God, questioning his existence. Is God even with us? Questioning his nature, questioning his word, did God really say this or that? Questioning his truthfulness to his promises, questioning his faithfulness, questioning his power, his goodness, his love, quavering, wavering on it, going back and forth. It's an essential instability, a rootless instability. James gives us this picture in James chapter 1:5, “But when he asks, he must believe and not doubt, because he who doubts is like a wave of the sea blown and tossed by the wind, that man should not think he'll receive anything from the Lord. He's a double-minded man, unstable in all his ways." That's the picture of doubt, isn't it? It's instability. It's like, I don't know, Will he? Won't he? Will it happen? I don't know. That's doubt. Paul, the apostle, cites Abraham, our father in faith, as a powerful example of faith despite all obstacles. Romans 4:19-21, talking about how he was going to have a son in his old age and his wife, his barren wife, would have a son in her old age, and he's dealing with that promise, the promise from God. Paul writes this about Abraham, "Without weakening in his faith, Abraham faced the fact that his body was as good as dead. Since he was about a hundred years old and that Sarah's womb was also dead." That's scoping the mountain. Well, it's a big mountain. He's looking at it. He's facing the fact that's going to be, it's impossible actually if God doesn't work. "Yet he did not waver through unbelief regarding the promise of God." That's Romans 4:20. That's a clear description of doubt, wavering through unbelief like a flickering light bulb, "But was strengthened in his faith and gave glory to God, being fully persuaded that God had power to do what he had promised." That's the essence of faith-filled prayer. God has power to do what He has promised He will do. So Jesus says, If anyone has faith and does not doubt but believes that what he has said will happen, that he has said in prayer, you going to speak prayer, and it's going to happen. Instead of doubting, this prayer warrior really believes a mountain's going to be lifted up and thrown into the sea. God has the power to do anything. And he reasons, which is harder for God to make the mountain out of nothing or to move it from one place to the other? You think about that, if God can make a mountain out of nothing, He can move it from one place to the other, and every mountain that exists on planet Earth, God made out of nothing. The prayer warrior believes that God has told him to pray for this. This mountain must move, and God has laid this burden on my heart. It is essential for this mountain to move for the kingdom of God to advance in this specific way that mountain's going to move. That's what faith and prayer is, is being a human channel of God's awesome power to do amazing things. The nature of faith therefore is perceiving and then receiving, perceiving then receiving. Perceiving the will of God as He has revealed it in scripture and in providence, and then receiving the will of God as He delivers it by his power and Jesus says, "It will be done for him." Prayer accomplishes amazing things, mighty things, but it doesn't in and of itself accomplish anything. It's always God that does things through prayer. It's God that moves the mountain. Your prayer didn't move anything. John Piper speaks of prayer in this way. "Prayer is the splicing of our limp wire to the lightning bolt of heaven." Isn't that a great image? Splicing your limp wires. Is your wire limp? Mine feels limp a lot. Splice that thing to the lightning of heaven and see what God will do. There's nothing mighty in prayer in and of itself. It's that God is mighty, and He answers prayer. Then Jesus gives a universal application in verse 24, "Therefore, I tell you, whatever you ask for in prayer, believe that you have received it, and it will be yours." It's awesome. Then He goes to another topic, it seems, look at verse 25, "And when you stand praying, if you hold anything against anyone, forgive him so that your Father in heaven may forgive you your sins.” When I was memorizing the Gospel of Mark, this one verse stuck out to me more than any other of the 876 verses, or 676 verses, in this Gospel, this one verse. Let me be honest, just like any sinner, I can easily hold things against people. It's easy to be bitter. It's easy to remember the hurts that people have done in your life. Any of you like that? Any of you specifically know right now that this person, that person or the other person has hurt you and you're holding something against them? It's really very remarkable here. Jesus is here, giving you effectively emancipation proclamation of your own slavery to bitterness. He's telling you, let it go. Just like the parable of the 10,000 talents, you've been forgiven much. You must forgive. And look at how sweeping it is, "Whenever you stand praying, if you hold anything against anyone, forgive him." In other words, every time you pray, it's an opportunity to do that. “Search me, oh, God, and know my heart. Show me if I'm bitter against somebody. Show me if I'm upset at my mom or dad or my son or daughter or my brother, my sister, a fellow church member, a pastor, a spouse, a husband, a wife, a neighbor, a roommate, a person from my past.” You know the person. You know the group of people. Maybe you have a lot of them. Anytime you pray, it's an opportunity to obey this verse and be set free. Set free. Stop drinking the poison. You're just set free from bitterness. Now you may wonder, what does it have to do with mountain moving, faith-filled prayer? It seems like an odd thing to go from verse 24 to 25, but not so much. Just keep in mind what is happening. The faith-filled, mountain-moving prayer is all about the building of the kingdom of God. How important would you say the forgiveness of sins will be in the kingdom of God? And is not that forgiveness going to be both vertical and horizontal? Are we not going to spend eternity in heaven with other sinners, some of whom we knew in life, and we'll be free, and there'll be no bitterness, there'll be nothing but sweet fellowship? So that's the kingdom Jesus is building, and He wants us to be set free and not harbor sin. An image on this came to me, I love Hebrews 4:16, it’s a great verse. It says, "Let us draw near to the throne of grace so that we may receive mercy and find grace to help in time of need.” Isn't that a great verse? The curtain and the temple, torn in two from top to bottom, is open. We have access to the throne of God. We're invited in this text to draw near to the throne of God, but before you enter the throne room of God, you got to give up your weapons. I watch the “Lord of the Rings” movies, some of you have as well. And in movie number two, a bunch of warriors are trying to get into the Hall of the King, Théoden, but they can't go in with their weapons. They have to leave their weapons at the door. That's the image I have here. You can't bring bitterness and unforgiveness to the throne of grace and expect to get anything from God. You got to let your weapons go. Now let me extend the image. I find it may be one of the hardest things there is to do in life. It's easy to hold onto bitterness. Have you ever heard of the expression nursing a grudge? What a weird thing to do to a grudge. I would kill the grudge, but instead we nurse it. Why? Because it puts us in a position of power. We can hold it over that person and be bitter toward them, and they can maybe walk on eggshells toward us and all that. Let it go. What's so beautiful is the one seated on the throne of grace, if we're having a problem, will come out to the doorway where we're having trouble giving up our weapons and say, “what's the problem here?" “Well, I want to come in, but they won't let me. I can see why they won’t.” “Can I help you with that? Can I help you get rid of that bitterness? Can I remind you that I forgave you all of that sin because you begged me to? Let it go. Let it go.” So that's walking through. III. Elements of Mountain-Moving Prayer Now, let's draw out elements of mountain-moving prayer. First of all, faith in God. Have faith in God. That has to do with history and theology. First of all, remember what God has done. Remember how Peter looked back and remembered that Jesus had cursed the fig tree? That's an issue of remembrance. Remember what God has done. Psalm 77:11-12, "I'll remember the deeds of the Lord. Yes, I'll remember your miracles of long ago. I will meditate on all your works and consider all your mighty deeds.” Think of God, the God of the Bible. Is there anything He cannot do? Think of the Red Sea crossing. Before that, think of creation. "In the beginning, God created heaven and earth." God can do anything. Look at his track record again and again and not just in the Bible, but look at his track record with you. How many of your prayers has He answered? George Mueller kept a record, a record book, 50,000 answers to prayer in connection with his care for 10,000 orphans over his life, 50,000 answers to prayer. He wrote them down, and that built and built and built his confidence in prayer, the specificity of it. So have faith in God, remember his mighty deeds, and think who God is. What should you consider when you have faith in God? I would say these elements, first of all, God's glory. Pray in reference to God's glory. God does everything for his glory. Whether you eat or drink, whatever you do, do it all for the glory of God. What is that? The manifestation of the perfections of God. Pray that in this moving of this mountain that God may be displayed as a great, loving, kind, powerful God. That God may be put on display, the glory of God. Secondly, God's omniscience. Keep in mind, God has already thoroughly studied the problem. He has all wisdom and knows exactly what to do. “Your father knows what you need before you ask him." [Matthew 6:8], or this Romans 11:33-34, "Oh, the depths of the riches and the wisdom and the knowledge of God! How unsearchable His judgments and his paths beyond tracing out! Who has known the mind of the Lord? Or who has been his counselor?" I'm going to say something in a minute about this, but let me tell you something. In prayer, you're not God's counselor. You do know that, don't you? It's not like, “God, let me tell you what I think you should do here.” We'll get to all that. Next, God's sovereignty. God is sovereign and has meticulously crafted a plan that goes down to the tiniest detail of every day of redemptive history. He's already sovereignly, decreed his will. Ephesians 1:11 says, "In him we were also chosen, having been predestined according to the plan of him who works out everything in conformity with the purpose of his will." That's everything. God is sovereign. God's omnipotence. There is nothing that God cannot do. Is anything too hard for God? Isaiah 40:26:"Lift up your eyes and look to the heavens: Who created all these? He who brings out the starry host one by one and calls them each by name because of his great power and mighty strength, not one of them is missing." The power of God. And then think of the goodness of God. God wants to do good things for his people. He wants that more than you do. Matthew 7:9-11 "Which of you, if his son asks for bread, will give him a stone? Or if he asks for a fish, will give him a snake? If you, then, though you are evil, know how to give good gifts to your children, how much more will your Father in heaven give good gifts to those who ask him!" God wants to give good gifts to us, and again, Romans 8:28, "We know that in all things, God works for the good of those who love God and are called according to his purpose." I've struggled my whole Christian life to understand the effectiveness of prayer. The prayer of a righteous man is powerful and effective, I'm told in James. I'm an engineer. I know what power and effect is. It means that I am a change agent. I'm a catalyst. I'm an earth mover, I guess, if I'm effective. That's not what effective prayer is. Prayer is not us, number one, teaching God a solution He hadn't thought of, or number two, persuading him to do something He didn't want to do before He talked to you. I know that that logically seems like effective prayer. It's like, it made a difference because I told God something He didn't know or I persuaded him to do something He wasn't going to do. That is not what powerful, effective prayer is all about. Rather, effective prayer is discerning what God has already determined to do and asking him to do it for His glory by his power. That's what effective prayer is. So putting it all together, whatever we pray, we do so mindful of God's glory and that is our top priority. God's omniscience in that God's already figured out what's best to do. God's plan, He's already decreed based on his wise plan. God's power, there's nothing He cannot do and God's goodness is in his desire to bless his people. We pray like that. He will give us anything we ask for. "Effective prayer is discerning what God has already determined to do and asking him to do it for His glory by his power." Now, what is the mountain that needs to be moved? Seeing the mountain that needs to be moved. “If you say to this mountain, go throw yourself in the sea, it will be done for you.” I said it's a specific obstacle to the spread of the gospel, a specific obstacle to the growth of the kingdom of God. That's what it is. So you could see that there's a specific government official somewhere withholding a visa, and he won't let some critical workers into a country because he is withholding a visa. It's a mountain that needs to be moved. Some prayer warrior praises until that individual, for some strange reason, changes his mind. That kind of stuff's happened again and again and again. Or a pastor being held at a restrictive nation, and the people of God pray, and he's released. That happened in the Bible with Peter. They prayed, the people of God, were praying even after James had been executed. They kept praying for Peter, and he was released, an answer to prayer. Or with George Muller's specific physical needs for hundreds and hundreds of orphans. They need to eat today, give them this day their daily bread, and then stuff happens. Amazing. You don't want to be driving a bread truck by the orphanage when there's a need. Your truck's going to break down, and you'll have nowhere else to go with that bread except the orphanage, and God answers those prayers. Now, what does it mean for us? What is our field? We are in the Raleigh/ Durham/ Chapel Hill area. We are positioned here by the wise plan of God. We're positioned here for the kingdom of God. We're positioned right here in Durham, this triangle area with the RTP and all that is attractive to people. People are moving in here in large numbers. Last night I went walking around all the restaurant areas. I walked all the way down to the Insomnia coffee or cookie place, I walked in there. There was no one there. I said, what time do you close? "3:00 AM.” Anyway, but there was no one working. That was interesting. Then I walked back, and as I was walking, I was thinking and praying. I was like, I wonder how many of these people are lost? They're pouring in here. They're living in all those condos and houses and all that that are being built, and the overwhelming majority of them are unchurched. They're lost. Our mountain to be moved is within their hearts, their hatred for Christ, their opposition to God. They're thinking they don't need any of this. That's our field, that's our mountain. That we would see baptisms in numbers like we have never seen before, that people would be brought from death to life because we boldly attempted great things for God after the first two things happen, expected great things, and ask great things. That's our mountain to be moved. We ask God to do it. We keep on asking and it will be given to us. We keep on seeking, and we'll find. We keep on knocking, and the door will be opened. As Jesus said, He told the parable of the persistent widow that they should always pray and never give up. I'm not a big fan of church sign ministry. Some of them are just cheesy. You know what I'm talking about. I mean, really bad, but I saw one that stuck with me. I really like it, “Pray until something happens." I love that. Doesn't it line up with this text? Pray until something happens. Keep praying until you see that mountain move. We expect God to answer. Mark 11:24, "I tell you, whatever you ask for in prayer, believe that you have received it, and it will be yours." Charles Spurgeon was talking to a young preacher about his lack of fruit and street evangelism. He preached again and again without seeing any converts at all. Spurgeon asked him, "Do you expect people to be converted every time you preach?" "No, sir." He said, "Well, that's the reason you don't succeed because you do not expect to do so. According to your faith, it will be done to you." Wow, Spurgeon's tough. Imagine him as your mentor. But what's our level of expectation? Do we expect to see people converted because of the witness of us? Expect it, and then be humble about sin. The next time you go to pray, ask the Lord to show you. Are you holding anything against anyone? Are you bitter toward anyone? Ask the Lord to help you forgive and to release. IV. Warnings Against Misunderstandings I have a section of my sermon here on warnings against misunderstandings about the “name it and claim it” thing and all that. I'm not going to say any of it. You want to know, come and ask, and I'll tell you about Creflo Dollar and all those guys, but I just don't think that's our problem. I don't think we're “name it and claim it” people. We're under-utilizers of the promises in this text. That's the problem. We're erring on the side of not asking enough. So let's ask and see what God can do. V. Lessons Applied to Us So applications, first of all, to any that are here that are lost, you're on the outside looking in. You don't know this, not like you should, but your sins are like a mountain that has to be moved. Your sins are like a mountain between you and friendship with God, adoption into God's family. That mountain has to be moved, and if it's not moved, you cannot come into sweet fellowship with God. In Micah chapter 7, He has promised that He will take our sins and throw them into the depths of the sea, and you'll see them no more. All you have to do is call in the name of the Lord Jesus, know that He shed his blood to provide that ocean of grace, and trust in him. Call on the name of the Lord, and He'll move that mountain of your sins and throw it in the depths of the sea, and you'll see it no more. For us as Christians, there's two applications: pray that we would pray. Let's start there. Pray that we'll become a praying church. That the obstacles to us praying like this would be removed, and that we pray as we have never prayed before, and that we would pray to fulfill the mission for which we have been positioned here in the Raleigh/ Durham/ Chapel Hill area, and that is the winning of lost people. Pray for that, and pray that we would be a sweet, gracious, and forgiving church. That whatever grievances we may have against each other, against anyone that we would readily, quickly forgive. We're going to go now to a time of the Lord's Supper, so I'm going to close the sermon in prayer. Father, thank you for the things we've learned in Mark's Gospel about mountain-moving, faith-filled prayer. We thank you for that, and we pray now that as we experience the Lord's Supper, that you would be mighty in this place, giving us an encounter with God, the living God, through the Ordinance of the Lord's Supper. In Jesus' name, Amen.

evergrande bankruptcy https://www.reuters.com/legal/china-evergrande-files-chapter-15-bankruptcy-us-court-filing-2023-08-17/ Sam Bankman-Fried sent to jail as judge revokes bail over witness tampering, VPN use https://www.theverge.com/2023/8/11/23829004/ftx-sam-bankman-fried-bail-revoked-vpn-signal Argentina's Leading Presidential Candidate Vows to Shut Down Central Bank if Elected https://www.nobsbitcoin.com/argentinas-prominent-presidential-candidate-milei-vows-to-shut-down-countrys-central-bank/ OpenSats: 9 new grants https://opensats.org/blog/bitcoin-and-nostr-grants-august-2023 & https://opensats.org/blog/josi-baker-receives-opensats-lts-grant Spiral Renewed Grant to Mogashni Naidoo from Bitcoin Design Community https://twitter.com/spiralbtc/status/1686037335589138432 BitGo Raised $100M Series C Round at $1.75Bn Valuation https://www.prweb.com/releases/bitgo-secures-100m-series-c-funding-at-1-75b-valuation-301901731.html July Mining Updates: Marathon, CleanSpark, Iris, Hive, Bitfarms, Core Scientific & More https://www.nobsbitcoin.com/july-2023-mining-updates/ KYC Mining Pools have more than 50% of hash rate https://primal.net/e/note1fkqfuhn3tr9l7d3czcuslf3vays2f2y6znls4kwhyg4hyllu5dkqkeftcg Trezor Suite v23.8.1: Coinjoin for Model One https://www.nobsbitcoin.com/trezor-suite-v23-8-1/ Geyser As Progressive Web App https://www.nobsbitcoin.com/you-can-now-install-geyser-as-progressive-web-app/ Phoenix Android v2.0.0: Splicing, Dual Funding & More https://www.nobsbitcoin.com/phoenix-wallet-v2-0-0/ Liquid Federation Open Sources Functionary Code https://www.nobsbitcoin.com/liquid-federation-open-sourced-its-functionary-code/ Stacker.News Adds Anon Accounts, Just-in-time Funding https://www.nobsbitcoin.com/stacker-news-anon-accounts/ Clams v1.8.2: UI Improvements https://www.nobsbitcoin.com/clams-v1-8-2/ Lightning Terminal v0.10.5-alpha https://www.nobsbitcoin.com/lightning-terminal-v0-10-5-alpha/ Bitcoin Tribe v2.2.1: Border Wallets https://www.nobsbitcoin.com/bitcoin-tribe-v2-2-1/ Zeus v0.8.0 Mainnet Alpha Opened to Community Supporters https://www.nobsbitcoin.com/zeus-v0-8-0-alpha-opened-to-community/ Libwally Core v0.9.1 https://www.nobsbitcoin.com/libwally-core-v0-9-1/ Nodeyez v23.07 https://www.nobsbitcoin.com/nodeyez-v23-07/ BDK v0.28.2 https://www.nobsbitcoin.com/bdk-v0-28-2/ BTCPay Server v1.11.2: Bug Fix Release https://www.nobsbitcoin.com/btcpay-server-v1-11-2/ Lume v1.2.0-beta: New UI and Onboarding Process https://www.nobsbitcoin.com/lume-v1-2-0-beta/ Njump: Static Nostr Gateway https://www.nobsbitcoin.com/njump/ w3.do: Free URL Shortener Powered by Nostr https://www.nobsbitcoin.com/w3-do-free-url-shortener-powered-by-nostr/ 0:00 - You're welcome, Carlos 2:30 - Dashboard 5:30 - What caused the dump? 16:00 - Charts and lines 21:05 - SBF going to jail 24:07 - Javier Milei 25:10 - TikTok psyops 34:30 - OpenSats news 37:50 - Spiral grant 38:18 - BitGo secures funding 40:22 - July mining update 46:00 - More psyops 52:20 - KYC pools 59:15 - Transaction censorship 1:02:50 - Boosts 1:11:20 - Software updates 1:21:05 - Wrapping up Shoutout to our sponsors: Unchained Capital https://unchained.com/concierge/ Coinkite https://coinkite.com/ TFTC Merch is Available: Shop Now https://merch.tftc.io/ Join the TFTC Movement: Main YT Channel https://www.youtube.com/c/TFTC21/videos Clips YT Channel https://www.youtube.com/channel/UCUQcW3jxfQfEUS8kqR5pJtQ Website https://tftc.io/ Twitter https://twitter.com/tftc21 Instagram https://www.instagram.com/tftc.io/ Follow Marty Bent: Twitter https://twitter.com/martybent Newsletter https://tftc.io/martys-bent/ Podcast https://tftc.io/podcasts/ Follow Odell: Twitter https://twitter.com/ODELL Newsletter https://tftc.io/the-sat-standard/ Podcast https://citadeldispatch.com/

Dusty Daemon joins me to talk about splicing on Bitcoin's lightning network. We talk about: What is splicing?  Splicing's potential privacy benefits Potential to undermine surveillance heuristics Splicing's efficiency gains Splicing as one tool in the toolkit Walkthrough of how it works Site: Site: Lightning Splicing Twitter: @dusty_daemon Sponsors: Pacific Bitcoin Festival (code LIVERA) CoinKite.com (code LIVERA) Lugano PlanB Forum Mempool.space Stephan Livera links: Follow me on Twitter @stephanlivera Subscribe to the podcast

Epigenetics: from Greek epi-/ἐπι-, meaning = “over, outside of” to genetics (i.e. heritable changes that are above the genes coded in the DNA). That is, genes code for various traits, but epigenetics controls when they are switched on or off, and how intensely. ✍️ Links and Show Notes The four dimensional human genome defies naturalistic explanations The genetic puppeteer Splicing and dicing the human genome Programmed Filling, Not Natural Selection?

Josh & Dan are joined by Chris Alaimo and Dom Bei to discuss some of the most interesting talks from Bitcoin 2023.  We give the wizards a second chance, learn about some INCREDIBLE second layer developments with Ark and Splicing, then turn the guns to RFK Jr's speech, and finish with our thoughts on AI development in the context of Bitcoin. Talks we focus on in the episode: —The Great Ordinal Debate —The Ark Announcement —Splicing on Lightning (Timestamp 3:57- 4:16) —RFK Jr. Keynote —Will A.I. Dream of Electric Bitcoin BCB Pod disclaimer here Watch video of this chat on YouTube here SHOW SPONSORS: SWAN — The place we choose to buy Bitcoin. Dollar cost average daily, weekly or monthly with a company that's Bitcoin only and encourages you to hold your own private keys. Visit Swan.com. For Swan PREMIUM FREE go to https://www.swanbitcoin.com/premium/blue-collar-bitcoin-experience-swan-premium-for-free/ and use PASSWORD: bluecollarbitcoin BITCOIN 2024: promo code “BCB24” for 10% off tickets. Happening in Nashville July 25-27 2024, Get tickets early and get the best price possible! Visit b.tc/conference COINKITE — PROMO CODE “BCB” for discount on ColdCard. Industry leaders in Bitcoin security hardware and fun devices, makers of the COLDCARD and other prominent items including opendime, satscard, tapsigner, the seedplate, coldpower, blockclock mini & blockclock micro. All available at coinkite.com START9 — Sovereign computing. Take back control of your data. Run a Bitcoin & Lightning node. Embassy One: A small uncompromising personal server, capable of running BTC Core. Embassy Pro: The most powerful, secure, and reliable private server in the world. Visit Start9.com CROWDHEALTH BTC — Use CODE BLUE to get 1st 3 months massively reduced at $49/month. Harness the Power of Bitcoin + Health Care. Join other Bitcoiners on a crowdfunding platform while accumulating Bitcoin in the process. Bitcoin specific crowd joincrowdhealth.com/bitcoin SUPPORT THE BCB PODCAST: Podcast 2.0 streaming on our favorite pod app, Fountain: You can earn & stream sats on Lightning Network while listening to pods! Also share and listen to standout clips with the Fountain community. SOCIAL MEDIA Twitter: you can follow us @blue_collarbtc, follow Chris @ChrisAlaimo6, follow Dom @Beiwatch1 Blue Collar Bitcoin on NOSTR: npub1a3hrd4wfawr578d5y5l0qgmh7lx8q6tumfq0h7eymmttt52veexqkcfg37 Video on YouTube, Subscribe Here EMAIL: Send questions or comments to bluecollarbitcoinpodcast@gmail.com

I'm joined by guests Tbast, Dusty, Tony, Jeff & Vivek to discuss lightning privacy and splicing. Discussion Topics: 00:01:17 Housekeeping 00:02:14 Guest introductions 00:04:29 Current state of LN privacy 00:05:40 Receiver privacy 00:06:58 Blinded paths 00:12:31 Obscurity of lightning 00:13:47 Onchain privacy compared to lightning privacy 00:19:57 Lightning privacy challenges 00:21:57 PTLCs 00:22:48 Routing and LSPs 00:24:20 Gossip filters 00:25:36 Gossip and BOLT7 summary 00:27:27 Speed of development 00:29:22 Lightning implementations and compatability 00:31:38 BOLT12 00:34:00 Why an additional node implementation? (LDK) 00:40:04 Feature experimentation and market validation 00:43:29 Communicating feature sets 00:45:05 Payment descriptions 00:47:32 Nostr and zaps 00:50:25 Custodial lightning and censorship resistance 00:54:39 Splicing 00:57:51 Scaling 01:01:32 Bitcoin core changes that would advance lightning 01:08:06 Testing, breaking and adversarial actions 01:12:48 Shadow channels 01:15:52 Splicing (cont.) 01:22:04 Payjoins and keysend 01:25:52 Blockspace concerns 01:34:04 Taproot channels and gossip 01:41:09 Splicing (cont.) 01:42:13 Signing, UTXOs and pre-signed splices 01:47:15 FROST 01:47:60 Swap-in potentium 01:48:49 ecash 01:53:18 Final thoughts Links & Contacts: Website: https://bitcoin.review/Podcast Twitter: https://twitter.com/bitcoinreviewhq NVK Twitter: https://twitter.com/nvk Telegram: https://t.me/BitcoinReviewPod Email: producer@coinkite.com Nostr & LN:⚡nvk@nvk.org (not an email!) Full show notes: https://bitcoin.review/podcast/episode-36

Tuesday Hour 1, Segment 1The Mike Taylor show airs weekdays on Ticket 760 (KTKR) from 2PM to 5PM.Follow Mike on Twitter: @MikeTaylorShowFollow Puma on Twitter: @biggestpumaFollow EZ on Twitter: @ErvinZelaya

I'm joined by guests ⁠⁠⁠⁠Future Paul & Calle to go through the list. Bitcoin • Bitcoin Software Releases & Project Updates 00:01:56 COLDCARD Mk4 00:06:23 Sparrow 00:10:58 Electrum 00:13:48 BTC Pay Server 00:15:16 RoboSats 00:16:42 BISQ 00:19:21 libwally-core 00:20:15 nix-bitcoin 00:20:56 Nunchuk Desktop 00:21:26 Blockstream Green iOS 00:22:34 Trezor 00:22:59 Fully Noded 00:23:45 Liana 00:24:00 mycitadel 00:24:28 rgb-core 00:27:18 Descriptor wallet library • Lightning Software Releases & Project Updates 00:27:54 MutinyNet 00:30:59 Zeus 00:33:51 Blixt 00:36:50 TORQ 00:37:19 Nutstash 00:38:18 Phoenix 00:38:54 Wavlake 00:39:41 Stemstr 00:40:27 Satimoto 00:41:31 Zaprite • Bitcoin & Lightning Project Spotlight 00:42:25 bitcoin.rocks 00:42:35 psbt.io 00:42:57 mercury-node 00:44:21 Parmanode 00:44:48 LNProxy.org Nostr • Nostr Software Releases & Project Updates 00:46:53 NIP-47: Nostr Wallet Connect 00:47:13 NIP-15 00:47:34 ananostr 00:50:43 Damus 00:50:58 Snort Social 00:51:08 Amethyst 00:51:21 nblog 00:52:20 Coracle • Nostr Project spotlight 00:52:44 nostrit 00:53:17 zapworthy 00:53:31 NostrGraph Dashboard 00:53:45 primal.net 00:56:00 Nostri.chat 00:57:49 N3XB Boosts 00:57:49 Thanks to everyone who streamed sats, and shoutout to our top boosters: Purple Deer, puravida, Magenta Panda, Magenta Boar, northofthewall, apemithrandir & mrmr. Bitcoin Optech Newsletter 00:59:20 244: Preventing stranded capital with multiparty channels and channel factories 00:59:34 245: Watchtower accountability proofs 01:00:49 246: Splicing specification & Proposed BIP for transaction terminology News & Noteworthy • Bitcoin 01:01:16 Bitcoin Whitepaper Hidden in macOS • Lightning 01:02:56 Hierarchical Channels Proposal 01:10:15 Lightspark platform launches 01:11:52 MicroStrategy email addresses to LN addresses 01:12:01 Wallet of Satoshi processed 905,000 Lightning payments in March 01:12:12 Wallet of Satoshi Point of Sale First Look • Nostr 01:12:17 Civ Kit: A Peer-to-Peer Electronic Market System 01:13:35 LNBits announces Nostr Market, Nostr Client & Nostr Relay • Privacy 01:19:59 Chivo Wallet censorship • Mining 01:20:44 Stratum v2 reference implementation update with Job Negotiator 01:20:55 Sweden to increase data center taxes by 6,000% 01:21:36 New York Times Bitcoin mining hitpiece + Pierre troll • Enterprise & Finance 01:24:32 Pocket acquires Bitkipi 01:24:39 Strike Send Globally is now available in Senegal, Benin, Rwanda, Ivory Coast, and Togo 01:24:47 Zebedee partners with Bitnob 01:24:52 Block partners with African crypto exchange Yellow Card • Privacy 01:25:44 LinkingLion: An entity linking Bitcoin transactions to IPs? • Reads 01:30:20 LNP/BP Standards Association educational website • Political 01:30:28 Launch Of UK's First Bitcoin-only Policy Organisation - Bitcoin Policy UK Audience Questions 01:30:33 "Join market, wasabi or samurai?" @BITCOINALLCAPS Links & Contacts Website: https://bitcoin.review/Podcast Twitter: https://twitter.com/bitcoinreviewhq NVK Twitter: https://twitter.com/nvk Telegram: https://t.me/BitcoinReviewPod Email: producer@coinkite.com Nostr & LN:⚡nvk@nvk.org (not an email!) Full show notes: https://bitcoin.review/podcast/episode-32/

Join Paul for this mobile podcast where he talks about Wago's and his opinions of them. Paul also talks about an upcoming podcast on the changes in section 680.26(B) for the 2023 NEC via a recently overturned emergency nature TIA. If you are interested in learning the National Electrical Code from an industry expert who knows how to break it down into easy-to-understand terms then visit https://fasttraxsystem.com and join the Fast Trax Family

Today's episode is a special takeover, hosted by Ibrahim Aly, a Metro High School junior participant in the PAST Foundation's Workforce Development Program. Ibrahim previously joined us on episode 165 to talk about using internships to encourage STEM careers, and we're thrilled to have him back to lead the conversation about fusion splicing.A panel of experts will join Ibrahim to discuss this exciting field. Pat Stichter, the hyper-scale trainer from Sumitomo, brings years of experience in the industry. Quin Jernigan, the economic workforce development manager from Amazon Web Services, will discuss the career opportunities available in this field and the skills needed to succeed. Wesley Olinger, the division manager from Team Fishel, will share his perspective on the importance of workforce development and training in this industry. Together, this panel will provide a comprehensive overview of fusion splicing and its potential as a career path. Join us as we learn more about this fascinating field and what it takes to succeed in it.To learn more, visit: pastfoundation.orgWe unbox:What fusion splicing is and what it has to do with Amazon's data centersWhat skills are essential to success in the fusion splicing industryThe things students can do today to get ready to enter this fieldResources:Learn more about Sumitomo: sumitomocorp.comConnect with Quin on LinkedIn: linkedin.com/in/quin-jernigan-phdConnect with Wesley on LinkedIn: linkedin.com/in/wesley-olinger-b9097210a165. Using Internships to Spur Interest in STEM Careers with Nikki StancampianoProduced by Nova Media

This week we discuss what is a MUTOA, MUTOA vs Consolidation Point, best way to splice ribbon fiber into a Corning Cassette, being paid for stand by time, high/low settings on punch tool and so much more Support the show

Exposing neurons to valproic acid, a well-known environmental risk factor for autism, disrupts their ability to generate different proteins from the same gene.

Exposing neurons to valproic acid, a well-known environmental risk factor for autism, disrupts their ability to generate different proteins from the same gene.

I'm joined by guests Calle, Roy, Rijndael & t-bast to discuss Bitcoin lightning. Discussion Topics 00:04:08 Lightning implementations 00:11:04 LN URL 00:14:45 Protocols and different implementations 00:19:10 Wallet interaction with base chain 00:25:41 Splicing 00:34:26:06 Cost of liquidity and opening/closing channels 00:39:07 Monetization 00:49:12 Compatability and LSPs 00:56:08 Incentives to monopolize 01:04:43 Attacks on lightning 01:10:20 Cashu & eCash 01:41:42 Competing L2s and alternative lightning networks 01:44:19 Security Links & Contacts: Website: https://bitcoin.review/Podcast Twitter: https://twitter.com/bitcoinreviewhq NVK Twitter: https://twitter.com/nvk Telegram: https://t.me/BitcoinReviewPod Email: producer@coinkite.com LN Address:⚡nvk@getalby.com (not an email!) Full show notes: https://bitcoin.review/podcast/episode-15/

Sturm and Mikey cover Jabba's Kit, GAC, the Splicing of Mods and their views on this. DataCrons, Omni's and Sturm teaches Mikey the new search engines for mods. Did Mikey unlock Malgus or does he suck that bad? More importantly IS STURMBOCK STEPPING AWAY FOR GOOD!? All comments are read and discussed. The PEOPLE have spoken.

Stacey digs into General Motors' announcement about the new upcoming hybrid and electric corvettes, should you splice two vehicles together and the pros and cons of the Biden administration's plan to allow the use of E-15 gas year round.

UFC 273 is in the books and the fellas recap a great weekend of fights. Splicing between a 9-hole golf round, and some tri-tip endeavors on the Traeger, the lads sprinkle in some upcoming fight talk, specifically the Belal v. Luque main event this weekend at UFC Apex. Cain Velasquez released a statement on his Instagram account today, the fellas touch on that, as well as address Ground Controls own Jesse Stirn with his upcoming Art of Scrap bout in Indiana this weekend. Please send us your clean work bits from the week.Links below for Jesse and his fight. See too Mike Mallot's post fight mention of Joey Rodriguez's daughter battling cancer, and his promise to give his win money donation to his coach's daughter hopeful swift recovery.Angies Gofundme: https://www.gofundme.com/f/help-angie-ko-cancerLink to Jesses Fight: https://www.artofscrapfights.com/