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7 episodes with splicing
7 episodes with splicing
3 episodes with splicing
2 episodes with splicing
3 episodes with splicing
2 episodes with splicing
2 episodes with splicing
3 episodes with splicing
3 episodes with splicing
Dr Thomas Cassini explains how the Undiagnosed Diseases Network group used advanced sequencing techniques to clarify the genotype in a child with an unusual phenotype for mitochondrial trifunctional protein deficiency. Mitochondrial trifunctional protein deficiency caused by a deep intronic deletion leading to aberrant splicing Thomas Cassini, et al https://doi.org/10.1002/jmd2.12459
Send us a textThis episode explores the intricacies of fusion splicing and its vital role in fiber optics, featuring insights from expert Jane Bailey. Listeners learn about the advantages of fusion splicing, the importance of cleanliness, safety measures, and practical tips to improve their skills in the field. • Introduction to the importance of fiber optics• Overview of fusion splicing and its advantages• Comparison of fusion splicing and mechanical splicing costs• Evolution of fusion splicing technology and its impact• Core alignment versus cladding alignment explained• Essential tips for effective fusion splicing• Discussion of contamination issues and their resolutions• Importance of safety in fiber optic work• Challenges of inside vs. outside plant splicing• Introduction to spider fiber and its benefits• Insights into OTDR testing and ghosting phenomenaSupport the showKnowledge is power! Make sure to stop by the webpage to buy me a cup of coffee or support the show at https://linktr.ee/letstalkcabling . Also if you would like to be a guest on the show or have a topic for discussion send me an email at chuck@letstalkcabling.com Chuck Bowser RCDD TECH#CBRCDD #RCDD
The company is also planning to conduct the clinical trial at sites in the EU.
The company has also launched a natural history study of patients to inform the planned clinical trial.
- bitcoin passes $0.1M milestone https://truthsocial.com/@realDonaldTrump/posts/113600319916325790 - strike launches bill pay for those of us who are all in bitcoin - trump says he will tariff any countries which leave the dollar https://truthsocial.com/@realDonaldTrump/posts/113573130299319701 - putin says nobody can ban bitcoin https://primal.net/e/note1jvzsqy474l267tf9hrx47e3n2msrxr2nstczevka7zukza2wxdrsphkjvn - Human Rights Foundation Story of the Week China | Prepares for Sanctions While Eyeing Taiwan China is actively studying sanctions imposed on Russia to prepare for potential repercussions if it invades Taiwan. Chinese officials visited Moscow's central bank, finance ministry, and other key agencies to analyze how Russia navigated economic restrictions. This proactive approach speaks to fears China may have over its $3.3 trillion in foreign reserves and overseas bank assets, which would face significant restrictions under Western sanctions. In an effort to mitigate these risks, China is working to diversify away from dollar-denominated assets and reduce reliance on US Treasury bonds, which underpin the global financial system. This comes amid escalating tensions with the US after Washington approved an arms shipment to Taiwan, prompting Beijing to vow “resolute countermeasures.” FinancialFreedomReport.org - BDK Code Audit https://bitcoindevkit.org/blog/_2024-q4-code-audit/ - Eclair v0.11.0: Official Bolt 12 Support, Splicing, Liquidity Ads & On-The-Fly Funding Prototypes https://www.nobsbitcoin.com/eclair-v0-11-0/ - Damus Notedeck Alpha Now Available to Purple Subscribers https://www.nobsbitcoin.com/damus-notedeck-v0-2-0/ - Coinbase says to not use VPNs https://www.nobsbitcoin.com/coinbase-asks-users-to-stop-using-vpns-and-ad-blockers/ - Alex Mashinsky: founder of bankrupt crypto firm to plead guilty to fraud https://www.theguardian.com/technology/2024/dec/03/alex-mashinsky-crypto-fraud-celsius - U.S. Officials Urge Americans to Use Encrypted Messaging Apps https://www.nobsbitcoin.com/u-s-officials-urge-americans-to-use-encrypted-messaging-apps/ - Corporate Transparency Act blocked nationwide by Texas judge https://news.bloombergtax.com/daily-tax-report/corporate-transparency-act-blocked-nationwide-by-texas-court - what bitcoin did relaunches - 1123 days, shoutout to yellow https://x.com/ICOffenderII/status/1864574706583547911 0:00 - Intro 3:52 - Let's gooooooooo 11:57 - Bitstein video 16:30 - Trump says you're welcome 18:15 - Shoutout to Yellow 20:29 - Dashboard 27:15 - Strike launches bill pay 30:47 - Putin bitcoin comment and BRICS talk 38:38 - Healthcare assassination 41:41 - HRF Story of the Week 43:34 - Boosts and Primal/Fountain talk 50:47 - Software updates 57:22 - Coinbase says no vpns 1:00:09 - Mashinsky guilty plea 1:08:15 - Marty failed Barstool 1:11:07 - US officials encourage encrypted comms 1:22:34 - Corp Transparency Act blocked 1:27:22 - WBD relaunch 1:29:40 - Get back to work Shoutout to our sponsors: Unchained https://unchained.com/concierge/ Coinkite https://coinkite.com/ Stakwork https://stakwork.ai/ TFTC Merch is Available: Shop Now https://merch.tftc.io/ Join the TFTC Movement: Main YT Channel https://www.youtube.com/c/TFTC21/videos Clips YT Channel https://www.youtube.com/channel/UCUQcW3jxfQfEUS8kqR5pJtQ Website https://tftc.io/ Twitter https://twitter.com/tftc21 Instagram https://www.instagram.com/tftc.io/ Follow Marty Bent: Twitter https://twitter.com/martybent Newsletter https://tftc.io/martys-bent/ Podcast https://tftc.io/podcasts/ Follow Odell: Nostr https://primal.net/odell Newsletter https://discreetlog.com/ Podcast https://citadeldispatch.com/
Dr. Evan Noch interviews Drs. Nathan Leclair, David Raleigh and Olga Anczukow about their recent manuscript entitled: "RNA splicing as a biomarker and phenotypic driver of meningioma DNA methylation groups", published online in Neuro-Oncology in August 2024.
Kruw runs the most successful Wasabi wallet 2.0 coordinator and is the kind of privacy advocate who actually builds. In this episode, he talks about continuing Wasabi, the shortcomings of Samourai & how blockchain analysis works. Time stamps: Introduction (00:00:39) Recap of Wasabi Wallet Discussions (00:01:33) Samourai Wallet's Decentralization Announcement (00:02:28) Challenges Faced by Privacy Projects (00:03:56) Shift in Bitcoin Culture (00:04:40) Impact of Regulatory Pressures (00:05:32) Wasabi's Resilience (00:06:40) Exploring Bitcoin's Privacy Features (00:07:53) Demonstrating CoinJoin Transactions (00:08:36) Differences Between CoinJoin and Monero (00:10:24) Challenges with Bitcoin Transaction Privacy (00:11:23) Concerns Over High Transaction Fees (00:13:11) Wasabi's New Features for Privacy (00:17:40) User-Friendly Features in Wasabi 2.0 (00:20:14) Transaction Speedup Options (00:21:18) Critique of UTXO Management in Wasabi 2.0 (00:23:05) Wasabi Wallet User Control (00:23:38) Switching Coordinators Feature (00:24:03) Decentralized Coordinator Community (00:24:50) User Preferences in Coordinator Selection (00:26:18) Coordinator Fees Discussion (00:30:56) Drivechains and Mining Concerns (00:31:04) Market Dynamics of Coordinator Fees (00:34:25) Collecting Dust from Transactions (00:37:43) Trezor's Coinjoin (00:38:09) Wasabi Wallet's Development Funding (00:41:14) Samourai Wallet's Blockchain Analysis Tool (00:42:36) Address Reuse and Privacy Challenges (00:46:49) Mistakes in Privacy Usage (00:49:40) Discrediting Wasabi Wallet (00:50:21) Cash Fusion (00:51:42) Reputation and Arrests (00:53:23) Bitcoin Privacy Camps (00:54:33) Join Market's Unique Position (00:55:56) Legal Risks in Bitcoin Coordination (00:56:21) The Fight for Bitcoin's Future (01:00:01) Personal Ethics and Legal Protections (01:01:42) Concerns Over Martyrdom (01:03:14) Physical Tokens and Authenticity (01:04:12) Critique of Samourai Wallet (01:05:10) Transparency Issues in Samurai Wallet (01:08:09) Closed Source vs. Open Source Debate (01:09:55) Default Privacy Features in Samurai Wallet (01:11:26) Ricochet Transactions and Fees (01:13:13) Government Awareness of Transactions (01:14:41) Implications of Fee Collection (01:15:01) Personal Standards and Hypocrisy (01:15:53) New Pepe Avatar Presentation (01:16:21) Nostr vs. Twitter (01:18:21) Support for CTV & Covenants (01:20:11) Governance and Community Dynamics (01:22:38) Concerns about ETF Privacy (01:22:53) Complexity of Consensus Changes (01:24:08) Community Understanding of Proposals (01:28:20) Censorship Resistance in Bitcoin (01:31:01) Market Dynamics and Filters (01:32:46) Historical Context of Data on Bitcoin (01:34:08) Criticism of Jimmy Song (01:35:31) Litecoin's Role in Segwit Activation (01:36:30) Bitcoin's Cultural Stagnation (01:37:47) Ranking Privacy Coins (01:39:45) Liquidity vs. Privacy (01:40:26) Technological Advancements in Privacy (01:41:39) User Resistance to New Technology (01:42:54) 10101 Shutdown (01:43:09) Drivechains and Altcoins (01:44:16) Monero Liquidity Concerns (01:45:58) Future of Bitcoin vs. Altcoins (01:46:29) Cultural Conflicts in Bitcoin Development (01:47:20) Blockstream's Influence (01:48:26) Whale Bots in Bitcoin (01:51:49) Michael Saylor's Influence (01:52:52) Bitcoin's Future and Development (01:55:07) Censorship Resistance vs. Privacy (01:59:08) Satoshi's Coins and Community Reaction (02:00:05) Blockchain Analysis Case (02:01:08) Challenges of Privacy Services (02:04:15) Tracking Methods in Blockchain (02:05:20) Understanding Transaction Outputs (02:06:39) Heuristics for Blockchain Analysis (02:09:03) Personal Experience with Blockchain Analysis (02:10:06) Samurai Wallet's Controversies (02:10:58) Victims vs. Heroes in Privacy Projects (02:13:37) Bitcoin Soft Forks for Privacy (02:16:46) Statechains and Privacy (02:18:18) Interactive Transactions Challenges (02:20:08) Monero and Chainalysis (02:22:25) Network Level Privacy Issues (02:23:01) Future of Privacy Tools (02:24:01) Zano's Hybrid Consensus Model (02:24:49) Tail Emission Interest (02:25:13) Consensus Mechanisms Explained (02:26:11) Future of Bitcoin on Layer 2 (02:27:05) Lightning Network, Finally (02:28:28) Privacy Concerns in Lightning (02:29:39) Confidentiality vs. Privacy (02:29:24) Splicing and Lightning Efficiency (02:30:12) Public vs. Unannounced Lightning Channels (02:32:40) Custodial Systems and Privacy (02:34:12) Investment in Privacy Technologies (02:35:31) Nym Security Token Overview (02:36:57) Challenges of Decentralization (02:40:03) Tor and Bitcoin Privacy (02:41:22) Running a Tor Relay (02:42:10) Discussion on Transaction Value (02:48:55) Counterarguments on Spam Incentives (02:49:34) Block Size Debate (02:51:20) Challenges of Block Size Increases (02:52:41) Ethereum vs. Bitcoin Cash (02:57:48) Dynamic Block Size Mechanisms (02:58:57) Running Full Nodes on Mobile (03:00:10) Wrap Up and Future Prospects (03:03:49)
Colletti's first produced feature, which was also his directorial debut, "Safe House," was the official selection of six major film festivals around the world: Slamdance, Slamdance Cannes, Hollywood Black Film Festival, San Francisco Black Film Festival, German Verzanbet Film Festival and Febiofest in Prague.With a film background in editing, Colletti's transition from the editing room to behind the camera has been seamless. He brought with him fifteen years of studio feature film experience, as outlined in his impressive resume.
John Carvalho is the CEO and founder of Synonym and has been in Bitcoin for over a decade. Right from the start, he knew he wanted to contribute to the ecosystem and dove head first into the technology. In this conversation with Relai CEO Julian Liniger, John shares his journey into Bitcoin, how he orange-pilled himself within a week, why he decided to found Synonym, and how their infrastructure contributes to growing the ecosystem. You can find John on X (Twitter) here:https://twitter.com/BitcoinErrorLog You can find out more about Synonym here: https://synonym.to/ — 00:00 - Intro 01:40 - How Silk Road influenced Bitcoin back in 2012 05:10 - Why did John decide to start working in Bitcoin 09:25 - Should there be a single Marketing entity in Bitcoin? 11:55 - Why does John think the spot Bitcoin ETFs are centralized? 14:20 - How large holders are an issue for the decentralization of Bitcoin 17:35 - Is there a way to scale Bitcoin to not lose small transactions on-chain? 23:00 - What scaling technology will be the go-to standard in the future? 28:15 - Why Lightning is the best scaling technology now, but we need to do better 36:00 - There will always be users or customers who want to use custodial services 42:25 - How do Julian and Relai rank stablecoins like Tether in the Bitcoin ecosystem? 47:15 - Are there incentives for users to use Bitcoin only in an app or with a service? 54:10 - How John revived RGB and why he decided to do so 56:25 - Why John doesn't believe that Splicing will work 58:21 - The main reason why John still works in Bitcoin 59:25 - John's Bitcoin allocation in his portfolio — Prefer to enjoy this show in audio format? Listen on Apple Podcast: https://podcasts.apple.com/at/podcast/relai-bitcoin-podcast/id1543267066 Listen on Spotify: https://open.spotify.com/show/06BdZid57RlCgBNsgr703A?si=5ec60cc680534b44 -- The opinions expressed on the show are the opinions of the individual guests and may not reflect the opinions of Relai AG. The information on the podcast may be changed without notice, and is not guaranteed to be correct, complete or up-to-date. -- Relai is Europe's easiest bitcoin investment app. The ‘Made in Switzerland' bitcoin investment app enables anyone in Europe to invest in bitcoin within minutes, without the need for registration, verification, or a deposit. You can buy bitcoin instantly or set up a weekly/monthly savings plan for as little as 25 CHF/EUR and invest in bitcoin automatically over time.
Genes are recipes for proteins and proteins do stuff. But if a gene can make more than one protein, how does that affect genetic variation and the possible routes to adaptation? We get an introduction to the topic of adaptive alternative splicing from David Manahan. Hosted on Acast. See acast.com/privacy for more information.
The federal government is cracking down on the "broken ice cream machines across fast food chains. A Woman is being charged for commiting Beastiality with her Great Dane & I've unlocked a new fear within myself about Cats. Follow me on Twitter & Instagram: @siddavis Podcast IG: @thesocialintrovertpodcast Podcast Twitter: @SocialintroPod Send emails to: thesocialintrovertpodcastegmail.com Music featured: Intro Song: Monroe Flow - Coolin' Stove God Cools & Stoupe - We Ballin' Again Outro Song: Pip Millett - Better --- Send in a voice message: https://podcasters.spotify.com/pod/show/the-social-introvert/message
Optimization has become an important goal within the electronics assembly industry. While modern electronics assembly techniques utilize a variety of equipment, one specific type of equipment often consumes a disproportionate percentage of the overall equipment budget, that is the place machine. The cost of the machine, associated conveyors and feeders, require that the machine is running as often as possible. The airline industry refers to this as “wheels up” time. Airlines make money when the aircraft is in the air “wheels up.” On the other hand, anytime the wheels are down, the aircraft is not making money for the airline. I listened to an interview a few years ago with the CEO of Southwest Airlines, a US discount carrier. Unlike most other airlines, Southwest does not charge its customers to check bags. The CEO was asked by the reporter why they have not joined the rest of the industry in charging for checked bags. The CEO's answer was genius. If Southwest Airlines began charging for check bags, it would actually slow the boarding process as more and more passengers would drag their bags onto the aircraft, most likely resulting in a number of those bags having to be checked at the gate. Southwest Airlines is famous for having the fastest aircraft gate turns in the industry, frequently under 30 minutes. Yet, if Southwest Airlines charged for checked baggage, it would require more time at the gate before the next flight would be ready to depart. That would result in fewer flight segments per aircraft per day. In other words, allowing customers to check bags for free equates to more “wheels up” time and, subsequently, more profit for the airline. The same principal can apply to pick-and place machines. When pick-and-place machines are running product, they are making presumably making money. When they sit idle, they are arguably costing money. What can assemblers do to improve the optimization or “wheels up” time on their pick-and-place machines? Mike Konrad's guest, Larry Welk, believes he has an answer. Welk, a.k.a. Professor Splice, is coowner of Smart Splice, a manufacturer of tape splicing tools. Welk reviews tape splicing best practices and explain how tape splicing, when performed correctly, can lead to higher pick-and-place machine optimization. So, buckle your seatbelt: this podcast episode is officially wheels up! Chapters: 00:00:00 - The Importance of Optimization in Electronic Assembly 00:02:34 - Tape Splicing: Best Practices 00:05:12 - Tape Splicing and its Advantages in the Industry 00:07:42 - Continuous Tape Splicing 00:10:10 - Splicing Techniques in Machine Assembly 00:12:31 - Ensuring Quality and Reliability of Tape Splices 00:14:57 - The importance of alignment in splicing 00:17:21 - Types of Tapes and Their Impact on Splicing 00:19:54 - Challenges with Tape Splicing 00:22:09 - Adjusting Feeder Tension 00:24:25 - Splicing and Reel Management in the Industry 00:26:46 - Splicing Parts in the Electronics Industry 00:29:02 - Common Mistakes in Tape Splicing 00:31:34 - Issues with Tape Splicing 00:34:03 - The Crimping Tool and Tape Issues 00:36:25 - The Importance of Switching Techniques 00:38:53 - Improving Production Efficiency through Component Evaluation 00:41:44 - A demonstration of the old tape splicing method 00:44:08 - Splicing Tape Procedure Comparison 00:46:38 - Faster Splicing Technique 00:49:15 - The Negative Experiences with Splicing 00:51:55 - The Benefits of Splicing 00:54:22 - Transitioning from Technician to Salesman 00:56:40 - Conclusion and Farewell
Optimization has become an important goal within the electronic assembly industry. While modern electronic assembly techniques utilize a variety of equipment, one specific type of equipment often consumes a disproportionate percentage of the overall equipment budget, that is the place machine. The cost of the machine, associated conveyors and feeders, require that the machine is running as often as possible.The airline Industry refers to this as “wheels up” time. Airlines make money when the aircraft is in the air “wheels up”. On the other hand, anytime the wheels are down, the aircraft is not making money for the airline.I listened to an interview a few years ago with the CEO of Southwest Airlines, a US discount carrier. Unlike most other airlines, Southwest does not charge its customers to check bags. The CEO was asked by the reporter why they have not joined the rest of the industry in charging for checked bags. The CEOs answer was genius. If Southwest Airlines began charging for check bags, it would actually slow down the boarding process as more and more passengers would drag their bags onto the aircraft most likely resulting in a number of those bags having to be checked at the gate. Southwest Airlines is famous for having the fastest aircraft gate turns in the industry, frequently under 30 minutes. Yes Southwest airlines charged for checked baggage, it would require more time at the gate before the next flight would be ready to depart. That would result in fewer flight segments per aircraft per day. In other words, allowing customers to check bags for free equates to more “wheels up” time and, subsequently, more profit for the airline.The same principal can apply to pick and place machines. When Pick and machines are running product, they are making presumably making money. When they sit idle, they are arguably costing money. What can assemblers do to improve the optimization or “wheels up” time on their pick and place machines?My guest today, Larry Welk believes he has an answer. Larry Welk, a.k.a. Professor spice is the co-owner of Smart Splice, a manufacturer of tape splicing tools.Larry will review tape splicing best practices and explain how tape splicing, when performed correctly, can lead to higher pick and place machine optimization.So, buckle your seatbelt this podcast episode is officially wheels up!Larry's Contact Information:Larry Welklwelk@smartsplice.comhttps://smartsplice.com/
Prepare to unlock the secrets of fusion splicing as we welcome the incomparable Ron Greenberg from UCL Swift, who shares his treasure trove of knowledge in our comprehensive series. Dispel any intimidation you might feel about this crucial skill; our step-by-step walkthrough and discussion with Ron reveal the simplicity and advancements that have made fusion splicing accessible for technicians everywhere. With the all-in-one fusion splicer as our Excalibur, we cut through the complexities to demonstrate just how manageable and efficient this process has become.Safety goggles on as we navigate the precision and safety that are the heart of fusion splicing in the ICT industry. We're zeroing in on splice loss standards, diving into the equipment technology that meets these stringent requirements, and addressing the safety measures that are non-negotiable in the field. Watch us in action during a live demo with the KF4A all-in-one fusion splicer, a marvel of technology that boasts advanced features to refine the splicing process. Whether you're a seasoned technician or a newcomer eager to learn, this segment will sharpen your skills and give you a clear view of the practicalities of splicing equipment, from battery management to the necessity of a wind cover.Our final narrative arc is tailored for the intrepid field technicians out there, those who splice fibers in the most challenging of environments. Hear tales from the trenches, like splicing in a commercial freezer or the bowels of a coal mine, and the solutions that can turn the tide in your favor. We emphasize maintaining and calibrating your splicing equipment to ensure it's always battle-ready. Plus, Ron and I share insights into promotions that put this critical gear within your reach. We wrap up with a vibrant Q&A session, extending a heartfelt thank you to Ron for his invaluable contributions. Join us for this series, as we connect the world one splice at a time, and don't forget to subscribe for more episodes that empower and inform.Support the showKnowledge is power! Make sure to stop by the webpage to buy me a cup of coffee or support the show at https://linktr.ee/letstalkcabling . Also if you would like to be a guest on the show or have a topic for discussion send me an email at chuck@letstalkcabling.com Chuck Bowser RCDD TECH#CBRCDD #RCDD
In this episode of Bitcoin, Explained, Aaron and Sjors are once more joined by Breez developer Jesse de Wit, this time to explain splicing. Splicing allows users of the Lightning Network to effectively add or remove funds from an active channel, allowing for continuous payment and routing activity. Aaron, Sjors and Jesse discuss what challenges this entails, and how these challenges are overcome. At the beginning of the episode, Sjors also gives a brief update on the ongoing TornadoCash trial in the Netherlands, and he addresses a recent block mined by Mara Pool. === This episode's sponsor: CoinKite, maker of the ColdCard Jesse's Twitter: @WitDeJesse Jesse's Nostr: npub18hwpk5qep3ptnmzatq22ptwr9mth7ccrku56rdntwpxjxlkfyr2qrav8du Aaron's Twitter: @AaronvanW Aaron's Nostr: npub1art8cs66ffvnqns5zs5qa9fwlctmusj5lj38j94lv0ulw0j54wjqhpm0w5 Sjors' Twitter: @provoost Sjors' Nostr: npub1s6z7hmmx2vud66f3utxd70qem8cwtggx0jgc7gh8pqwz2k8cltuqrdwk4c If you'd like to sponsor the show, please email info at bitcoinexplainedpodcast.com. https://bitcoinexplainedpodcast.com/
Kerry College, in collaboration with Amazon Web Services (AWS) and Sumitomo Electric Lightwave, proudly announces the successful completion of a two-day fibre splicing workshop as part of the Kerry College Open Week 2024. The workshop, held at our Monavalley Campus, catered to both members of the public and current learners engaged in various courses and apprenticeships. Recognised as leaders in optical fibre technologies, AWS and Sumitomo Electric Lightwave joined forces with Kerry College to offer an immersive learning experience focusing on fibre installation and data centre fields. The workshops aimed to raise awareness about skill needs and career prospects in these dynamic and growing sectors. Amazon Web Services (AWS) is the world's most comprehensive and broadly adopted cloud computing provider, offering over 200 fully featured services to clients globally. Millions of customers, including start-ups, large enterprises, and government agencies, are using AWS to lower costs, become more agile, and innovate faster. According to Ms. Joanne Reynolds, AWS Community Engagement Manager, "At AWS in Ireland, we are committed to working with Irish educational institutions to equip graduates with skills for today's economy. This two-day workshop offers a unique pathway for employers to upskill their staff, as well as an option for members of the public to learn invaluable new skills. AWS is delighted to collaborate with Kerry ETB on this project, which will help to enhance the skill base in the region as well as highlighting the career opportunities available to those who enter this sector." The response to the workshop was overwhelmingly positive, with a capacity attendance of 35 learners. Participants were predominantly from the Kerry region, but some learners travelled from as far as Donegal to attend. Additionally, several learners enrolled from local employers, reflecting the workshop's relevance to regional industry needs. Throughout the two-day event, participants delved into the fundamentals of fibre optic installation, repair, and splicing. They also gained hands-on experience by practising real-world deployment techniques, ranging from traditional hand tools to cutting-edge automated fusion splicing technology. Kerry College Monavalley Campus Manager Mr Con O'Sullivan noted, "We are delighted to have had the opportunity to work with AWS and Sumitomo Electric Lightwave and collaborate with them to deliver this unique learning and development opportunity for Kerry." Mr O'Sullivan added, "This is a fantastic programme for those already in the industry who want to develop their skills and knowledge even further, but also for potential career changers who are interested in learning more about this exciting and growing industry." Upon completion of the workshop, Kerry College Monavalley Campus hosted a certificate ceremony, where Kerry ETB Board Chairperson, Cllr. Jim Finucane awarded AWS Certificates of Completion to all successful learners. Councillor Finucane welcomed the initiative and commended AWS, Sumitomo Electric Lightwave and Kerry College for ''delivering relevant, in-demand education and training provision to meet industry needs.' The ceremony was graced by esteemed guests, including Joanne Reynolds, Community Engagement Manager at AWS; Con O'Sullivan, Monavalley Campus Manager; Allyson Eastman, Economic and Workforce Development Manager at AWS; and Lauren Deloatch, Project Manager at Sumitomo Electric Lightwave. This collaborative effort between Kerry College, AWS, and Sumitomo Electric Lightwave underscores a commitment to fostering talent, promoting industry-aligned education, and empowering learners with practical skills essential for future career success. More about Irish Tech News Irish Tech News are Ireland's No. 1 Online Tech Publication and often Ireland's No.1 Tech Podcast too. You can find hundreds of fantastic previous episodes and subscribe using whatever platform you like via our Anchor.fm page he...
I am Jack's 34th minute I start with splicing single frames of pornography into family films and I end with seasoning the lobster bisque at the Pressman hotel. Hosts Bubbawheat and Lance Stanford discuss the David Fincher movie Fight Club one minute at a time. They are joined this week by guest Chris Derkotch. Follow Chris Derkotch: Jay and Silent Bob Minute Follow Bubbawheat: On Instagram, Threads, Twitter aka X Follow Lance: On Instagram, Threads, Twitter aka X Enter to win a copy of Fight Club 2 by sending a screenshot of a podcast review to FightClubMinute@gmail.com Produced by Bubbawheat Member of Rabbit Hole Podcasts Opening music by the No Corporation
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In this week's episode we'll discuss if fractionated dosing of gemtuzumab ozogamicin provide additional benefit over a single dose in older adults with AML. Then, we'll consider how the loss-of-function of ENT3 drives histiocytosis. Researchers describe a novel pathway leading to histiocytosis that involves hyperactivation of TLR-MAPKinase signaling. This suggests a potential benefit of MAPKinase -directed targeted therapy in a range of histocytoses. Finally we'll discuss unraveling resistance mechanisms to anti-CD20 treatments in B-cell malignancies. Through alternative splicing, the MS4A1 gene encoding human CD20 generates multiple mRNA isoforms with distinct 5' untranslated regions.
In this week's episode we'll discuss the prognostic significance of splicing factor gene mutations in newly diagnosed AML, learn more about the findings from a multi-omics study of therapy resistance in multiple myeloma, and discuss the effects of KIT ligand deletion on systemic KIT levels and hematopoietic stem cell homeostasis.
The next generation of Bitcoin Lightning wallets is here with Phoenix from ACINQ. Rejoining me is CTO of ACINQ, Bastien Teinturier to talk about how the team is innovating a great self custodial experience for bitcoin and lightning users: High Fee environment New Phoenix fee structure Splicing and what it enables Dual Funding Liquidity Ads Building on a smartphone app Can ACINQ steal from users? APO Biggest challenges Reasons to be optimistic Bastien links: Twitter: @realtbast Phoenix Splicing Update post Sponsors: Pacific Bitcoin Festival (code LIVERA) CoinKite.com (code LIVERA) Mempool.space Stephan Livera links: Follow me on Twitter @stephanlivera Subscribe to the podcast
Chris sits down with Nate from Voltage to talk about the ins and outs of the Lightning Network, ARK, Splicing, and Running a Lightning Node Lower your time preference and lock-in your Bitcoin 2024 and Bitcoin Amsterdam conference tickets today!!! Use promo code BMLIVE for 10% off your tickets! https://b.tc/conference/ Use promo code BMLIVE for 10% off everything in our store! https://store.bitcoinmagazine.com/ IMPORTANT DISCLAIMER "All views expressed by hosts, guests, and interviewees of "Bitcoin Magazine Live" are opinion only and do not reflect the views of Bitcoin Magazine, its ownership, management, any of their associated or affiliated entities, or their inhouse or third party service providers and platforms. This program is informational only, and its content does not contain or construe any offers to buy, sell, or hold any bitcoin, other cryptocurrency, or any securities or other financial instruments in the United States or any other jurisdiction in which such solicitation or offer would be unlawful. Nor does this show's programming constitute any kind of legal, tax, investment, financial, or other advice. Individuals who appear on "Bitcoin Magazine Live" are not deemed investment advisors and their performances in the past are not indicative of future results. Nor are staff or management of "Bitcoin Magazine Live," its publishers and affiliated companies in the business of providing advice, financial or otherwise. All investment carries risk and you should do your own due diligence before investing."
It is important to ask for great things from God, seeking by faith to perceive what God wills to do and by prayers to be involved in his work. - SERMON TRANSCRIPT - Turn in your Bibles to Mark 11. We resume a series now in the Gospel of Mark, and the focus, as you heard in my prayer today, is Mountain-Moving Prayer. On Wednesday, May 30th, 1792, at Friar Lane Baptist Chapel in Nottingham, England, a simple cobbler named William Carey preached one of the greatest sermons in church history. It was later called the Deathless Sermon. It was a call for Christians to make every effort to take the gospel to unreached peoples to the ends of the earth and to the end of time. Up to that point in history, missionaries had usually been Roman Catholic, often Jesuits who are taking Roman power to distant lands, but not the pure gospel. Christians who had rediscovered the gospel through the reformation led by Martin Luther, John Calvin, and others had, up to that point, not really gotten that involved in foreign missions. William Carey would be a pivotal leader in the history of Protestant missions and would himself be part of the solution when he boarded a ship and went to Kolkata, India. William Carey's deathless sermon was broken into two main headings. Number one, expect great things from God, and number two, attempt great things for God. Since that time, at the close of the 18th century, the true gospel has spread to every political nation on earth and the number of genuine Christians all over the world has exploded beyond all boundaries. We don't know how can we know how many are truly born again, but the number may be 500 million, 700 million, a billion, 1.5 billion. We don't know, but it's astonishing. Compared to that, the moving of a physical mountain into the depths of the sea is as nothing. I'm going to take liberties with our brother, William Carey. I don't think he'll mind me adding a third heading to the sermon. I'm not trying to improve on a deathless sermon. How could I? Certainly, we should expect great things from God, but before we can attempt great things for God, I think, based on the text I'm going to preach today, we should ask great things of God. That links the two. Expecting great things, asking great things, attempting great things. I don't think William Carey would mine. Mountain-moving prayer links our expectations, great expectations with great actions. Look at the text, “'Have faith in God.’ Jesus answered. ‘I tell you the truth, if anyone says to this mountain, go throw yourself into the sea, and does not doubt in his heart, but believes that what he has said will happen, it will be done for him. Therefore, I tell you, whatever you ask in prayer, believe that you have received it, and it will be yours.’” The passage is stunning. Jesus uses lavish language to charge his people to ask God to do mighty things and answer to prayer. So let's set the context. I. From a Withered Fig Tree to a Fruitful Church We're moving from a withered fig tree to a fruitful church. It is the last week of Jesus's life. Lots of dramatic moments are happening, beginning with the triumphal entry into Jerusalem. “Hosanna! Hallelujah to the son of David. Blessed it is the coming kingdom of our father, David,” all of that. He goes to the temple, scouts it out. But because it's so late, He goes out of the city to Bethany. The next morning, He goes back in to cleanse the temple, to purify the temple of all that wickedness. En route, He sees this fig tree. Look at verses 12 -14. "The next day, as they were leaving Bethany, Jesus was hungry, seeing in the distance of fig tree and leaf. He went to find out if it had any fruit. When he reached it, he found nothing but leaves because it was not the season for figs. Then he said to the tree, ‘May no one ever eat fruit from you again,’ and his disciples heard him say it.” Now, Jesus' hunger was both physical and prophetical. Jesus represented his father, and this fig tree symbolized Israel. God wanted fruit from Israel from centuries of him pouring out blessings on that nation. But the tree had only leaves, just as Israel had only an appearance of spiritual vitality, but without any genuine fruit in the sight of God. It represented essentially a spiritually dead Israel. So Jesus cursed the tree in a massively significant prophetical action. Prophets did this kind of thing, these kind of symbolic actions. The cursed fig tree died instantly, but not apparently so, not in appearance. Moments after Jesus cursed it, it looked the same. Just like the nation of Israel had leaves and would continue seemingly apparently alive for decades before God finally brought the hammer blow down through the Romans in A.D. 70, destroying the temple. So, immediately after the cursing, it looks fine, but the next morning radically different. The moment Jesus cursed it, it died. But the next morning, it became apparent that that's what had happened. The following morning, Peter noticed and remembered, look at verse 20-21, "In the morning, as they went along, they saw the fig tree withered from the roots. Peter remembered and said to Jesus, ‘Rabbi, look the fig tree, you cursed is withered.’" There's nothing miraculous about a fig tree withering, but there is something miraculous about that happening after powerful words spoken by the son of God, and hours later it looks like it's been dead for years. Now that's a miracle, and the disciples wanted to understand it. In Matthew's Gospel, they asked the question, how did the fig tree wither so quickly? That's the issue. So Jesus at that moment pivots to teach about faith-filled prayer. On the surface, this may seem a bit strange. How did the fig tree wither so quickly? Have faith in God and ask great things in prayer. What's the connection? How do we understand why that lesson at that moment? I think the connection, the link, is fruit. The reason that the fig tree was cursed was fruitlessness. The reason that God would judge Israel was the same fruitlessness. He's about to tell a parable of a vineyard that He's going to give this same lesson on the issue of fruit. In that parable, Jesus speaks of a vineyard planted by an owner. The owner works the soil thoroughly, plants the vines, puts a wall around it, digs out a wine press, and builds a watchtower. Then he rents out the vineyard to some tenant farmers and leaves. But when he sends messengers to collect his share of the fruit, they beat one, kill another, stone a third. Last of all, he sends a son, and they kill him too. In Matthew's telling of that parable, Jesus sums it all up. Matthew 21:43, "Therefore, I tell you, the kingdom of God will be taken away from you." He says to his enemies, "And given to a people who will produce its fruit." Friends, that's us. That's our job. It's given to the church, both Jews and Gentiles, believers in Christ. It's given to us to produce the fruit of the kingdom, and that fruit will only come about by the power of Almighty God, and that expressed in prayer as we pray. I want you to take a minute, put your finger here in Mark, and go over to John 15, and we're going to look at verses 5-8. This is a phenomenal cross-reference. Usually, cross-references are okay, give them a B+ for connection. But this is a top to bottom cross-reference connection here. The lesson of the withered fig tree and the issue of fruitfulness is overtly and clearly taught in John 15:5-8. Look what it says. Jesus said, "I am the vine. You are the branches. If anyone remains in me, and I in him, he'll bear much fruit. Apart from me, you can do nothing. If anyone does not remain in me, he's like a branch that is thrown away and what withers. Such branches are picked up and thrown into the fire, and burned. If you remain in me and my words remain in you, then ask whatever you wish, and it will be given to you. This is to my Father's glory that you bear much fruit, showing yourselves to be my disciples." Surely you must see the points of connection here. It's an agricultural image, that's true, not a fig tree in this case, but a vine with branches. But this goal is the same. It's fruit. A fruitless branch is severed from the vine, thrown to the ground. It withers, and it's thrown to the fire and burned, judgment. Branches that remain in Jesus, people like you and me that stay close to Jesus are intimately connected with him through repentance and faith and are alive in him and stay connected with him. We abide in him. We can pray. If we have God's word saturating our minds, we will know what to pray for. We're not guessing here. God will tell us in his word, what we should pray for, and as we are saturating God's Word, if we remain in him and his words dwell, or abide, or remain in us, then we will ask according to his will, we'll ask whatever we wish, and it will be done for us. In this way, we'll bear the fruit of the kingdom that He talked about. Go back to Mark now, and you see those same lessons. This is a new lesson for his apostles, they were not prayer warriors up to this point. They were not men of prayer. He says in John 16:24, "Until now, you have not asked for anything in my name. Ask and you'll receive, and your joy will be complete." You've not learned this lesson to pray. They're about to be commissioned to go into all the world and be fishers of men, and build the kingdom of God to the ends of the earth. They've got to be men of prayer. So He says in John 14:12-14, "I tell you the truth, anyone who has faith in me will do what I have been doing. He will do even greater things than these because I am going to the Father, and I will do whatever you ask in my name so that the son may bring glory to the Father." You may ask me for anything in my name, and I'll do it. It's prayer. It's prayer. Again and again, it's prayer. There are lots of mountains to be moved from Jerusalem through Judea, and Samaria to the ends of the earth. Lots of mountains had to be moved. People's hearts would have to be changed. The heart of stone removed, the heart of flesh given. People would have to cross over from death to life, and there'd be practical aspects of the spread of the gospel, obstacles that would have to be overcome or moved out of the way. Lots of mountains would have to be moved, and only the Holy Spirit could move them, and He would do it in answer to faith-filled prayer, Mountain-Moving Prayer. That's why Jesus went from the dead fig tree to a lesson on prayer. II. Walking Through Jesus’ Words So let's walk through it now. Let's look at the words. Let's just go step by step through what He says. I'll read them again, beginning at verse 22. "Have faith in God. I tell you the truth, if anyone says to this mountain, go throw yourself into the sea, and does not doubt in his heart but believes that what he has said will happen, it will be done for him. Therefore, I tell you, whatever you ask for in prayer, believe that you have received it, and it will be yours. And when you stand praying, if you hold anything against anyone, forgive him that your Father in heaven may forgive you your sins.” Just walk through it, it begins with the statement, “have faith in God.” Jesus points his disciples to Almighty God as the focus of their lives and especially the focus of their prayer. Focus on God. Faith is the eyesight of the soul, by which you see the invisible God on his throne. Focus on that. Have faith in him. Everything comes from God. For him and through him and to him are all things in his hand is every blessing you want. He opens his hand and satisfies the desires of every living thing. Have faith in the God who can give you what you want, what you need. Have faith in God. Then He says, "Truly, I say to you." Jesus says this from time to time. Everything Jesus said was true, but when he says, “truly, I say to you” or something like that, He's saying, pay attention. Take notice. This is a very important thing I'm about to say to you. Unusually significant, a solemn assertion. Then Jesus says, "If anyone says..." The doctrine He's about to give about prayer is universal; it's for all his followers, not just for the apostles, or for the super spiritual ones, or for the real super leaders, the great William Carey. It's for anyone and everyone. “If anyone says,” basically, in these words, He's going to give three universals. “If anyone says”... so it's any person and then, anything. Whatever you ask in prayer, you'll receive it. Amazing. And then, any unforgiven sin. If you hold anything against anyone, forgive him, these are universals. Sweeping statements “If anyone says.. .” Jesus is expanding our conception of prayer. God is able to immeasurably more than all we ask or imagine. "God is able to immeasurably more than all we ask or imagine. " Then He says, "If anyone says to this mountain, go throw yourself into the sea." Now this should not be taken literally. Some of you have literalistic minds, right? It's like, well, that's it. We believe in errancy, pastor. I do believe in errancy, but I also believe in figures of speech. This is a figure of speech. Jesus did this. He said to the Pharisees, “you strain out a gnat and swallow a camel.” I'm going to stop you right there, you literalist. That never happened. It's a metaphor. You're focused on tiny details, and you're missing the big picture. The mountain represents some massive obstacle to the plan of God. That's what the mountain represents. This mountain, was almost certainly the Mount of Olives, and just so you know from Zechariah 14, God has plans for the Mount of Olives, He doesn't want it moved and thrown into the sea. It's going to be the very place where Jesus will return at the second coming, so let's just leave that mountain right there. In any case, it's a metaphor, and it represents massive obstacles to the plan of God. Then He says, "and does not doubt." Now we get to the issue of doubt. The enemy of faith is doubt. The essence of doubt is questioning God, questioning his existence. Is God even with us? Questioning his nature, questioning his word, did God really say this or that? Questioning his truthfulness to his promises, questioning his faithfulness, questioning his power, his goodness, his love, quavering, wavering on it, going back and forth. It's an essential instability, a rootless instability. James gives us this picture in James chapter 1:5, “But when he asks, he must believe and not doubt, because he who doubts is like a wave of the sea blown and tossed by the wind, that man should not think he'll receive anything from the Lord. He's a double-minded man, unstable in all his ways." That's the picture of doubt, isn't it? It's instability. It's like, I don't know, Will he? Won't he? Will it happen? I don't know. That's doubt. Paul, the apostle, cites Abraham, our father in faith, as a powerful example of faith despite all obstacles. Romans 4:19-21, talking about how he was going to have a son in his old age and his wife, his barren wife, would have a son in her old age, and he's dealing with that promise, the promise from God. Paul writes this about Abraham, "Without weakening in his faith, Abraham faced the fact that his body was as good as dead. Since he was about a hundred years old and that Sarah's womb was also dead." That's scoping the mountain. Well, it's a big mountain. He's looking at it. He's facing the fact that's going to be, it's impossible actually if God doesn't work. "Yet he did not waver through unbelief regarding the promise of God." That's Romans 4:20. That's a clear description of doubt, wavering through unbelief like a flickering light bulb, "But was strengthened in his faith and gave glory to God, being fully persuaded that God had power to do what he had promised." That's the essence of faith-filled prayer. God has power to do what He has promised He will do. So Jesus says, If anyone has faith and does not doubt but believes that what he has said will happen, that he has said in prayer, you going to speak prayer, and it's going to happen. Instead of doubting, this prayer warrior really believes a mountain's going to be lifted up and thrown into the sea. God has the power to do anything. And he reasons, which is harder for God to make the mountain out of nothing or to move it from one place to the other? You think about that, if God can make a mountain out of nothing, He can move it from one place to the other, and every mountain that exists on planet Earth, God made out of nothing. The prayer warrior believes that God has told him to pray for this. This mountain must move, and God has laid this burden on my heart. It is essential for this mountain to move for the kingdom of God to advance in this specific way that mountain's going to move. That's what faith and prayer is, is being a human channel of God's awesome power to do amazing things. The nature of faith therefore is perceiving and then receiving, perceiving then receiving. Perceiving the will of God as He has revealed it in scripture and in providence, and then receiving the will of God as He delivers it by his power and Jesus says, "It will be done for him." Prayer accomplishes amazing things, mighty things, but it doesn't in and of itself accomplish anything. It's always God that does things through prayer. It's God that moves the mountain. Your prayer didn't move anything. John Piper speaks of prayer in this way. "Prayer is the splicing of our limp wire to the lightning bolt of heaven." Isn't that a great image? Splicing your limp wires. Is your wire limp? Mine feels limp a lot. Splice that thing to the lightning of heaven and see what God will do. There's nothing mighty in prayer in and of itself. It's that God is mighty, and He answers prayer. Then Jesus gives a universal application in verse 24, "Therefore, I tell you, whatever you ask for in prayer, believe that you have received it, and it will be yours." It's awesome. Then He goes to another topic, it seems, look at verse 25, "And when you stand praying, if you hold anything against anyone, forgive him so that your Father in heaven may forgive you your sins.” When I was memorizing the Gospel of Mark, this one verse stuck out to me more than any other of the 876 verses, or 676 verses, in this Gospel, this one verse. Let me be honest, just like any sinner, I can easily hold things against people. It's easy to be bitter. It's easy to remember the hurts that people have done in your life. Any of you like that? Any of you specifically know right now that this person, that person or the other person has hurt you and you're holding something against them? It's really very remarkable here. Jesus is here, giving you effectively emancipation proclamation of your own slavery to bitterness. He's telling you, let it go. Just like the parable of the 10,000 talents, you've been forgiven much. You must forgive. And look at how sweeping it is, "Whenever you stand praying, if you hold anything against anyone, forgive him." In other words, every time you pray, it's an opportunity to do that. “Search me, oh, God, and know my heart. Show me if I'm bitter against somebody. Show me if I'm upset at my mom or dad or my son or daughter or my brother, my sister, a fellow church member, a pastor, a spouse, a husband, a wife, a neighbor, a roommate, a person from my past.” You know the person. You know the group of people. Maybe you have a lot of them. Anytime you pray, it's an opportunity to obey this verse and be set free. Set free. Stop drinking the poison. You're just set free from bitterness. Now you may wonder, what does it have to do with mountain moving, faith-filled prayer? It seems like an odd thing to go from verse 24 to 25, but not so much. Just keep in mind what is happening. The faith-filled, mountain-moving prayer is all about the building of the kingdom of God. How important would you say the forgiveness of sins will be in the kingdom of God? And is not that forgiveness going to be both vertical and horizontal? Are we not going to spend eternity in heaven with other sinners, some of whom we knew in life, and we'll be free, and there'll be no bitterness, there'll be nothing but sweet fellowship? So that's the kingdom Jesus is building, and He wants us to be set free and not harbor sin. An image on this came to me, I love Hebrews 4:16, it’s a great verse. It says, "Let us draw near to the throne of grace so that we may receive mercy and find grace to help in time of need.” Isn't that a great verse? The curtain and the temple, torn in two from top to bottom, is open. We have access to the throne of God. We're invited in this text to draw near to the throne of God, but before you enter the throne room of God, you got to give up your weapons. I watch the “Lord of the Rings” movies, some of you have as well. And in movie number two, a bunch of warriors are trying to get into the Hall of the King, Théoden, but they can't go in with their weapons. They have to leave their weapons at the door. That's the image I have here. You can't bring bitterness and unforgiveness to the throne of grace and expect to get anything from God. You got to let your weapons go. Now let me extend the image. I find it may be one of the hardest things there is to do in life. It's easy to hold onto bitterness. Have you ever heard of the expression nursing a grudge? What a weird thing to do to a grudge. I would kill the grudge, but instead we nurse it. Why? Because it puts us in a position of power. We can hold it over that person and be bitter toward them, and they can maybe walk on eggshells toward us and all that. Let it go. What's so beautiful is the one seated on the throne of grace, if we're having a problem, will come out to the doorway where we're having trouble giving up our weapons and say, “what's the problem here?" “Well, I want to come in, but they won't let me. I can see why they won’t.” “Can I help you with that? Can I help you get rid of that bitterness? Can I remind you that I forgave you all of that sin because you begged me to? Let it go. Let it go.” So that's walking through. III. Elements of Mountain-Moving Prayer Now, let's draw out elements of mountain-moving prayer. First of all, faith in God. Have faith in God. That has to do with history and theology. First of all, remember what God has done. Remember how Peter looked back and remembered that Jesus had cursed the fig tree? That's an issue of remembrance. Remember what God has done. Psalm 77:11-12, "I'll remember the deeds of the Lord. Yes, I'll remember your miracles of long ago. I will meditate on all your works and consider all your mighty deeds.” Think of God, the God of the Bible. Is there anything He cannot do? Think of the Red Sea crossing. Before that, think of creation. "In the beginning, God created heaven and earth." God can do anything. Look at his track record again and again and not just in the Bible, but look at his track record with you. How many of your prayers has He answered? George Mueller kept a record, a record book, 50,000 answers to prayer in connection with his care for 10,000 orphans over his life, 50,000 answers to prayer. He wrote them down, and that built and built and built his confidence in prayer, the specificity of it. So have faith in God, remember his mighty deeds, and think who God is. What should you consider when you have faith in God? I would say these elements, first of all, God's glory. Pray in reference to God's glory. God does everything for his glory. Whether you eat or drink, whatever you do, do it all for the glory of God. What is that? The manifestation of the perfections of God. Pray that in this moving of this mountain that God may be displayed as a great, loving, kind, powerful God. That God may be put on display, the glory of God. Secondly, God's omniscience. Keep in mind, God has already thoroughly studied the problem. He has all wisdom and knows exactly what to do. “Your father knows what you need before you ask him." [Matthew 6:8], or this Romans 11:33-34, "Oh, the depths of the riches and the wisdom and the knowledge of God! How unsearchable His judgments and his paths beyond tracing out! Who has known the mind of the Lord? Or who has been his counselor?" I'm going to say something in a minute about this, but let me tell you something. In prayer, you're not God's counselor. You do know that, don't you? It's not like, “God, let me tell you what I think you should do here.” We'll get to all that. Next, God's sovereignty. God is sovereign and has meticulously crafted a plan that goes down to the tiniest detail of every day of redemptive history. He's already sovereignly, decreed his will. Ephesians 1:11 says, "In him we were also chosen, having been predestined according to the plan of him who works out everything in conformity with the purpose of his will." That's everything. God is sovereign. God's omnipotence. There is nothing that God cannot do. Is anything too hard for God? Isaiah 40:26:"Lift up your eyes and look to the heavens: Who created all these? He who brings out the starry host one by one and calls them each by name because of his great power and mighty strength, not one of them is missing." The power of God. And then think of the goodness of God. God wants to do good things for his people. He wants that more than you do. Matthew 7:9-11 "Which of you, if his son asks for bread, will give him a stone? Or if he asks for a fish, will give him a snake? If you, then, though you are evil, know how to give good gifts to your children, how much more will your Father in heaven give good gifts to those who ask him!" God wants to give good gifts to us, and again, Romans 8:28, "We know that in all things, God works for the good of those who love God and are called according to his purpose." I've struggled my whole Christian life to understand the effectiveness of prayer. The prayer of a righteous man is powerful and effective, I'm told in James. I'm an engineer. I know what power and effect is. It means that I am a change agent. I'm a catalyst. I'm an earth mover, I guess, if I'm effective. That's not what effective prayer is. Prayer is not us, number one, teaching God a solution He hadn't thought of, or number two, persuading him to do something He didn't want to do before He talked to you. I know that that logically seems like effective prayer. It's like, it made a difference because I told God something He didn't know or I persuaded him to do something He wasn't going to do. That is not what powerful, effective prayer is all about. Rather, effective prayer is discerning what God has already determined to do and asking him to do it for His glory by his power. That's what effective prayer is. So putting it all together, whatever we pray, we do so mindful of God's glory and that is our top priority. God's omniscience in that God's already figured out what's best to do. God's plan, He's already decreed based on his wise plan. God's power, there's nothing He cannot do and God's goodness is in his desire to bless his people. We pray like that. He will give us anything we ask for. "Effective prayer is discerning what God has already determined to do and asking him to do it for His glory by his power." Now, what is the mountain that needs to be moved? Seeing the mountain that needs to be moved. “If you say to this mountain, go throw yourself in the sea, it will be done for you.” I said it's a specific obstacle to the spread of the gospel, a specific obstacle to the growth of the kingdom of God. That's what it is. So you could see that there's a specific government official somewhere withholding a visa, and he won't let some critical workers into a country because he is withholding a visa. It's a mountain that needs to be moved. Some prayer warrior praises until that individual, for some strange reason, changes his mind. That kind of stuff's happened again and again and again. Or a pastor being held at a restrictive nation, and the people of God pray, and he's released. That happened in the Bible with Peter. They prayed, the people of God, were praying even after James had been executed. They kept praying for Peter, and he was released, an answer to prayer. Or with George Muller's specific physical needs for hundreds and hundreds of orphans. They need to eat today, give them this day their daily bread, and then stuff happens. Amazing. You don't want to be driving a bread truck by the orphanage when there's a need. Your truck's going to break down, and you'll have nowhere else to go with that bread except the orphanage, and God answers those prayers. Now, what does it mean for us? What is our field? We are in the Raleigh/ Durham/ Chapel Hill area. We are positioned here by the wise plan of God. We're positioned here for the kingdom of God. We're positioned right here in Durham, this triangle area with the RTP and all that is attractive to people. People are moving in here in large numbers. Last night I went walking around all the restaurant areas. I walked all the way down to the Insomnia coffee or cookie place, I walked in there. There was no one there. I said, what time do you close? "3:00 AM.” Anyway, but there was no one working. That was interesting. Then I walked back, and as I was walking, I was thinking and praying. I was like, I wonder how many of these people are lost? They're pouring in here. They're living in all those condos and houses and all that that are being built, and the overwhelming majority of them are unchurched. They're lost. Our mountain to be moved is within their hearts, their hatred for Christ, their opposition to God. They're thinking they don't need any of this. That's our field, that's our mountain. That we would see baptisms in numbers like we have never seen before, that people would be brought from death to life because we boldly attempted great things for God after the first two things happen, expected great things, and ask great things. That's our mountain to be moved. We ask God to do it. We keep on asking and it will be given to us. We keep on seeking, and we'll find. We keep on knocking, and the door will be opened. As Jesus said, He told the parable of the persistent widow that they should always pray and never give up. I'm not a big fan of church sign ministry. Some of them are just cheesy. You know what I'm talking about. I mean, really bad, but I saw one that stuck with me. I really like it, “Pray until something happens." I love that. Doesn't it line up with this text? Pray until something happens. Keep praying until you see that mountain move. We expect God to answer. Mark 11:24, "I tell you, whatever you ask for in prayer, believe that you have received it, and it will be yours." Charles Spurgeon was talking to a young preacher about his lack of fruit and street evangelism. He preached again and again without seeing any converts at all. Spurgeon asked him, "Do you expect people to be converted every time you preach?" "No, sir." He said, "Well, that's the reason you don't succeed because you do not expect to do so. According to your faith, it will be done to you." Wow, Spurgeon's tough. Imagine him as your mentor. But what's our level of expectation? Do we expect to see people converted because of the witness of us? Expect it, and then be humble about sin. The next time you go to pray, ask the Lord to show you. Are you holding anything against anyone? Are you bitter toward anyone? Ask the Lord to help you forgive and to release. IV. Warnings Against Misunderstandings I have a section of my sermon here on warnings against misunderstandings about the “name it and claim it” thing and all that. I'm not going to say any of it. You want to know, come and ask, and I'll tell you about Creflo Dollar and all those guys, but I just don't think that's our problem. I don't think we're “name it and claim it” people. We're under-utilizers of the promises in this text. That's the problem. We're erring on the side of not asking enough. So let's ask and see what God can do. V. Lessons Applied to Us So applications, first of all, to any that are here that are lost, you're on the outside looking in. You don't know this, not like you should, but your sins are like a mountain that has to be moved. Your sins are like a mountain between you and friendship with God, adoption into God's family. That mountain has to be moved, and if it's not moved, you cannot come into sweet fellowship with God. In Micah chapter 7, He has promised that He will take our sins and throw them into the depths of the sea, and you'll see them no more. All you have to do is call in the name of the Lord Jesus, know that He shed his blood to provide that ocean of grace, and trust in him. Call on the name of the Lord, and He'll move that mountain of your sins and throw it in the depths of the sea, and you'll see it no more. For us as Christians, there's two applications: pray that we would pray. Let's start there. Pray that we'll become a praying church. That the obstacles to us praying like this would be removed, and that we pray as we have never prayed before, and that we would pray to fulfill the mission for which we have been positioned here in the Raleigh/ Durham/ Chapel Hill area, and that is the winning of lost people. Pray for that, and pray that we would be a sweet, gracious, and forgiving church. That whatever grievances we may have against each other, against anyone that we would readily, quickly forgive. We're going to go now to a time of the Lord's Supper, so I'm going to close the sermon in prayer. Father, thank you for the things we've learned in Mark's Gospel about mountain-moving, faith-filled prayer. We thank you for that, and we pray now that as we experience the Lord's Supper, that you would be mighty in this place, giving us an encounter with God, the living God, through the Ordinance of the Lord's Supper. In Jesus' name, Amen.
evergrande bankruptcy https://www.reuters.com/legal/china-evergrande-files-chapter-15-bankruptcy-us-court-filing-2023-08-17/ Sam Bankman-Fried sent to jail as judge revokes bail over witness tampering, VPN use https://www.theverge.com/2023/8/11/23829004/ftx-sam-bankman-fried-bail-revoked-vpn-signal Argentina's Leading Presidential Candidate Vows to Shut Down Central Bank if Elected https://www.nobsbitcoin.com/argentinas-prominent-presidential-candidate-milei-vows-to-shut-down-countrys-central-bank/ OpenSats: 9 new grants https://opensats.org/blog/bitcoin-and-nostr-grants-august-2023 & https://opensats.org/blog/josi-baker-receives-opensats-lts-grant Spiral Renewed Grant to Mogashni Naidoo from Bitcoin Design Community https://twitter.com/spiralbtc/status/1686037335589138432 BitGo Raised $100M Series C Round at $1.75Bn Valuation https://www.prweb.com/releases/bitgo-secures-100m-series-c-funding-at-1-75b-valuation-301901731.html July Mining Updates: Marathon, CleanSpark, Iris, Hive, Bitfarms, Core Scientific & More https://www.nobsbitcoin.com/july-2023-mining-updates/ KYC Mining Pools have more than 50% of hash rate https://primal.net/e/note1fkqfuhn3tr9l7d3czcuslf3vays2f2y6znls4kwhyg4hyllu5dkqkeftcg Trezor Suite v23.8.1: Coinjoin for Model One https://www.nobsbitcoin.com/trezor-suite-v23-8-1/ Geyser As Progressive Web App https://www.nobsbitcoin.com/you-can-now-install-geyser-as-progressive-web-app/ Phoenix Android v2.0.0: Splicing, Dual Funding & More https://www.nobsbitcoin.com/phoenix-wallet-v2-0-0/ Liquid Federation Open Sources Functionary Code https://www.nobsbitcoin.com/liquid-federation-open-sourced-its-functionary-code/ Stacker.News Adds Anon Accounts, Just-in-time Funding https://www.nobsbitcoin.com/stacker-news-anon-accounts/ Clams v1.8.2: UI Improvements https://www.nobsbitcoin.com/clams-v1-8-2/ Lightning Terminal v0.10.5-alpha https://www.nobsbitcoin.com/lightning-terminal-v0-10-5-alpha/ Bitcoin Tribe v2.2.1: Border Wallets https://www.nobsbitcoin.com/bitcoin-tribe-v2-2-1/ Zeus v0.8.0 Mainnet Alpha Opened to Community Supporters https://www.nobsbitcoin.com/zeus-v0-8-0-alpha-opened-to-community/ Libwally Core v0.9.1 https://www.nobsbitcoin.com/libwally-core-v0-9-1/ Nodeyez v23.07 https://www.nobsbitcoin.com/nodeyez-v23-07/ BDK v0.28.2 https://www.nobsbitcoin.com/bdk-v0-28-2/ BTCPay Server v1.11.2: Bug Fix Release https://www.nobsbitcoin.com/btcpay-server-v1-11-2/ Lume v1.2.0-beta: New UI and Onboarding Process https://www.nobsbitcoin.com/lume-v1-2-0-beta/ Njump: Static Nostr Gateway https://www.nobsbitcoin.com/njump/ w3.do: Free URL Shortener Powered by Nostr https://www.nobsbitcoin.com/w3-do-free-url-shortener-powered-by-nostr/ 0:00 - You're welcome, Carlos 2:30 - Dashboard 5:30 - What caused the dump? 16:00 - Charts and lines 21:05 - SBF going to jail 24:07 - Javier Milei 25:10 - TikTok psyops 34:30 - OpenSats news 37:50 - Spiral grant 38:18 - BitGo secures funding 40:22 - July mining update 46:00 - More psyops 52:20 - KYC pools 59:15 - Transaction censorship 1:02:50 - Boosts 1:11:20 - Software updates 1:21:05 - Wrapping up Shoutout to our sponsors: Unchained Capital https://unchained.com/concierge/ Coinkite https://coinkite.com/ TFTC Merch is Available: Shop Now https://merch.tftc.io/ Join the TFTC Movement: Main YT Channel https://www.youtube.com/c/TFTC21/videos Clips YT Channel https://www.youtube.com/channel/UCUQcW3jxfQfEUS8kqR5pJtQ Website https://tftc.io/ Twitter https://twitter.com/tftc21 Instagram https://www.instagram.com/tftc.io/ Follow Marty Bent: Twitter https://twitter.com/martybent Newsletter https://tftc.io/martys-bent/ Podcast https://tftc.io/podcasts/ Follow Odell: Twitter https://twitter.com/ODELL Newsletter https://tftc.io/the-sat-standard/ Podcast https://citadeldispatch.com/
Dusty Daemon joins me to talk about splicing on Bitcoin's lightning network. We talk about: What is splicing? Splicing's potential privacy benefits Potential to undermine surveillance heuristics Splicing's efficiency gains Splicing as one tool in the toolkit Walkthrough of how it works Site: Site: Lightning Splicing Twitter: @dusty_daemon Sponsors: Pacific Bitcoin Festival (code LIVERA) CoinKite.com (code LIVERA) Lugano PlanB Forum Mempool.space Stephan Livera links: Follow me on Twitter @stephanlivera Subscribe to the podcast
Epigenetics: from Greek epi-/ἐπι-, meaning = “over, outside of” to genetics (i.e. heritable changes that are above the genes coded in the DNA). That is, genes code for various traits, but epigenetics controls when they are switched on or off, and how intensely. ✍️ Links and Show Notes The four dimensional human genome defies naturalistic explanations The genetic puppeteer Splicing and dicing the human genome Programmed Filling, Not Natural Selection?
Josh & Dan are joined by Chris Alaimo and Dom Bei to discuss some of the most interesting talks from Bitcoin 2023. We give the wizards a second chance, learn about some INCREDIBLE second layer developments with Ark and Splicing, then turn the guns to RFK Jr's speech, and finish with our thoughts on AI development in the context of Bitcoin. Talks we focus on in the episode: —The Great Ordinal Debate —The Ark Announcement —Splicing on Lightning (Timestamp 3:57- 4:16) —RFK Jr. Keynote —Will A.I. Dream of Electric Bitcoin BCB Pod disclaimer here Watch video of this chat on YouTube here SHOW SPONSORS: SWAN — The place we choose to buy Bitcoin. Dollar cost average daily, weekly or monthly with a company that's Bitcoin only and encourages you to hold your own private keys. Visit Swan.com. For Swan PREMIUM FREE go to https://www.swanbitcoin.com/premium/blue-collar-bitcoin-experience-swan-premium-for-free/ and use PASSWORD: bluecollarbitcoin BITCOIN 2024: promo code “BCB24” for 10% off tickets. Happening in Nashville July 25-27 2024, Get tickets early and get the best price possible! Visit b.tc/conference COINKITE — PROMO CODE “BCB” for discount on ColdCard. Industry leaders in Bitcoin security hardware and fun devices, makers of the COLDCARD and other prominent items including opendime, satscard, tapsigner, the seedplate, coldpower, blockclock mini & blockclock micro. All available at coinkite.com START9 — Sovereign computing. Take back control of your data. Run a Bitcoin & Lightning node. Embassy One: A small uncompromising personal server, capable of running BTC Core. Embassy Pro: The most powerful, secure, and reliable private server in the world. Visit Start9.com CROWDHEALTH BTC — Use CODE BLUE to get 1st 3 months massively reduced at $49/month. Harness the Power of Bitcoin + Health Care. Join other Bitcoiners on a crowdfunding platform while accumulating Bitcoin in the process. Bitcoin specific crowd joincrowdhealth.com/bitcoin SUPPORT THE BCB PODCAST: Podcast 2.0 streaming on our favorite pod app, Fountain: You can earn & stream sats on Lightning Network while listening to pods! Also share and listen to standout clips with the Fountain community. SOCIAL MEDIA Twitter: you can follow us @blue_collarbtc, follow Chris @ChrisAlaimo6, follow Dom @Beiwatch1 Blue Collar Bitcoin on NOSTR: npub1a3hrd4wfawr578d5y5l0qgmh7lx8q6tumfq0h7eymmttt52veexqkcfg37 Video on YouTube, Subscribe Here EMAIL: Send questions or comments to bluecollarbitcoinpodcast@gmail.com
I'm joined by guests Tbast, Dusty, Tony, Jeff & Vivek to discuss lightning privacy and splicing. Discussion Topics: 00:01:17 Housekeeping 00:02:14 Guest introductions 00:04:29 Current state of LN privacy 00:05:40 Receiver privacy 00:06:58 Blinded paths 00:12:31 Obscurity of lightning 00:13:47 Onchain privacy compared to lightning privacy 00:19:57 Lightning privacy challenges 00:21:57 PTLCs 00:22:48 Routing and LSPs 00:24:20 Gossip filters 00:25:36 Gossip and BOLT7 summary 00:27:27 Speed of development 00:29:22 Lightning implementations and compatability 00:31:38 BOLT12 00:34:00 Why an additional node implementation? (LDK) 00:40:04 Feature experimentation and market validation 00:43:29 Communicating feature sets 00:45:05 Payment descriptions 00:47:32 Nostr and zaps 00:50:25 Custodial lightning and censorship resistance 00:54:39 Splicing 00:57:51 Scaling 01:01:32 Bitcoin core changes that would advance lightning 01:08:06 Testing, breaking and adversarial actions 01:12:48 Shadow channels 01:15:52 Splicing (cont.) 01:22:04 Payjoins and keysend 01:25:52 Blockspace concerns 01:34:04 Taproot channels and gossip 01:41:09 Splicing (cont.) 01:42:13 Signing, UTXOs and pre-signed splices 01:47:15 FROST 01:47:60 Swap-in potentium 01:48:49 ecash 01:53:18 Final thoughts Links & Contacts: Website: https://bitcoin.review/Podcast Twitter: https://twitter.com/bitcoinreviewhq NVK Twitter: https://twitter.com/nvk Telegram: https://t.me/BitcoinReviewPod Email: producer@coinkite.com Nostr & LN:⚡nvk@nvk.org (not an email!) Full show notes: https://bitcoin.review/podcast/episode-36
Tuesday Hour 1, Segment 1The Mike Taylor show airs weekdays on Ticket 760 (KTKR) from 2PM to 5PM.Follow Mike on Twitter: @MikeTaylorShowFollow Puma on Twitter: @biggestpumaFollow EZ on Twitter: @ErvinZelaya
I'm joined by guests Future Paul & Calle to go through the list. Bitcoin • Bitcoin Software Releases & Project Updates 00:01:56 COLDCARD Mk4 00:06:23 Sparrow 00:10:58 Electrum 00:13:48 BTC Pay Server 00:15:16 RoboSats 00:16:42 BISQ 00:19:21 libwally-core 00:20:15 nix-bitcoin 00:20:56 Nunchuk Desktop 00:21:26 Blockstream Green iOS 00:22:34 Trezor 00:22:59 Fully Noded 00:23:45 Liana 00:24:00 mycitadel 00:24:28 rgb-core 00:27:18 Descriptor wallet library • Lightning Software Releases & Project Updates 00:27:54 MutinyNet 00:30:59 Zeus 00:33:51 Blixt 00:36:50 TORQ 00:37:19 Nutstash 00:38:18 Phoenix 00:38:54 Wavlake 00:39:41 Stemstr 00:40:27 Satimoto 00:41:31 Zaprite • Bitcoin & Lightning Project Spotlight 00:42:25 bitcoin.rocks 00:42:35 psbt.io 00:42:57 mercury-node 00:44:21 Parmanode 00:44:48 LNProxy.org Nostr • Nostr Software Releases & Project Updates 00:46:53 NIP-47: Nostr Wallet Connect 00:47:13 NIP-15 00:47:34 ananostr 00:50:43 Damus 00:50:58 Snort Social 00:51:08 Amethyst 00:51:21 nblog 00:52:20 Coracle • Nostr Project spotlight 00:52:44 nostrit 00:53:17 zapworthy 00:53:31 NostrGraph Dashboard 00:53:45 primal.net 00:56:00 Nostri.chat 00:57:49 N3XB Boosts 00:57:49 Thanks to everyone who streamed sats, and shoutout to our top boosters: Purple Deer, puravida, Magenta Panda, Magenta Boar, northofthewall, apemithrandir & mrmr. Bitcoin Optech Newsletter 00:59:20 244: Preventing stranded capital with multiparty channels and channel factories 00:59:34 245: Watchtower accountability proofs 01:00:49 246: Splicing specification & Proposed BIP for transaction terminology News & Noteworthy • Bitcoin 01:01:16 Bitcoin Whitepaper Hidden in macOS • Lightning 01:02:56 Hierarchical Channels Proposal 01:10:15 Lightspark platform launches 01:11:52 MicroStrategy email addresses to LN addresses 01:12:01 Wallet of Satoshi processed 905,000 Lightning payments in March 01:12:12 Wallet of Satoshi Point of Sale First Look • Nostr 01:12:17 Civ Kit: A Peer-to-Peer Electronic Market System 01:13:35 LNBits announces Nostr Market, Nostr Client & Nostr Relay • Privacy 01:19:59 Chivo Wallet censorship • Mining 01:20:44 Stratum v2 reference implementation update with Job Negotiator 01:20:55 Sweden to increase data center taxes by 6,000% 01:21:36 New York Times Bitcoin mining hitpiece + Pierre troll • Enterprise & Finance 01:24:32 Pocket acquires Bitkipi 01:24:39 Strike Send Globally is now available in Senegal, Benin, Rwanda, Ivory Coast, and Togo 01:24:47 Zebedee partners with Bitnob 01:24:52 Block partners with African crypto exchange Yellow Card • Privacy 01:25:44 LinkingLion: An entity linking Bitcoin transactions to IPs? • Reads 01:30:20 LNP/BP Standards Association educational website • Political 01:30:28 Launch Of UK's First Bitcoin-only Policy Organisation - Bitcoin Policy UK Audience Questions 01:30:33 "Join market, wasabi or samurai?" @BITCOINALLCAPS Links & Contacts Website: https://bitcoin.review/Podcast Twitter: https://twitter.com/bitcoinreviewhq NVK Twitter: https://twitter.com/nvk Telegram: https://t.me/BitcoinReviewPod Email: producer@coinkite.com Nostr & LN:⚡nvk@nvk.org (not an email!) Full show notes: https://bitcoin.review/podcast/episode-32/
Join Paul for this mobile podcast where he talks about Wago's and his opinions of them. Paul also talks about an upcoming podcast on the changes in section 680.26(B) for the 2023 NEC via a recently overturned emergency nature TIA. If you are interested in learning the National Electrical Code from an industry expert who knows how to break it down into easy-to-understand terms then visit https://fasttraxsystem.com and join the Fast Trax Family
Conservative Mouthpiece Radio - Join The "Patriot Party" and have a VOICE
Join Paul for this mobile podcast where he talks about Wago's and his opinions of them. Paul also talks about an upcoming podcast on the changes in section 680.26(B) for the 2023 NEC via a recently overturned emergency nature TIA. If you are interested in learning the National Electrical Code from an industry expert who knows how to break it down into easy-to-understand terms then visit https://fasttraxsystem.com and join the Fast Trax Family
Today's episode is a special takeover, hosted by Ibrahim Aly, a Metro High School junior participant in the PAST Foundation's Workforce Development Program. Ibrahim previously joined us on episode 165 to talk about using internships to encourage STEM careers, and we're thrilled to have him back to lead the conversation about fusion splicing.A panel of experts will join Ibrahim to discuss this exciting field. Pat Stichter, the hyper-scale trainer from Sumitomo, brings years of experience in the industry. Quin Jernigan, the economic workforce development manager from Amazon Web Services, will discuss the career opportunities available in this field and the skills needed to succeed. Wesley Olinger, the division manager from Team Fishel, will share his perspective on the importance of workforce development and training in this industry. Together, this panel will provide a comprehensive overview of fusion splicing and its potential as a career path. Join us as we learn more about this fascinating field and what it takes to succeed in it.To learn more, visit: pastfoundation.orgWe unbox:What fusion splicing is and what it has to do with Amazon's data centersWhat skills are essential to success in the fusion splicing industryThe things students can do today to get ready to enter this fieldResources:Learn more about Sumitomo: sumitomocorp.comConnect with Quin on LinkedIn: linkedin.com/in/quin-jernigan-phdConnect with Wesley on LinkedIn: linkedin.com/in/wesley-olinger-b9097210a165. Using Internships to Spur Interest in STEM Careers with Nikki StancampianoProduced by Nova Media
This week Shorty & Cracker look back at the recent Pro Tour. They discuss the decks as well as the coverage and how they think Pioneer is looking. Then they get Splicy in Standard with Shortys over the top Jeskai list he will be playing at the Super Series this weekend. List can be found here Head to this link to register for our upcoming events: magicbeanscast.com If you want to grab some sweet bargains, then check out the daily auctions on Josh & Pat's MTG Bazaar. Find them on Facebook or follow this link and let them know the Beans sent you jpmtgbazaar.com.au You can also pick up some Magic Beans merchandise from our merch store magicbeanscast.com/check-out-the-magic-beans-merch-on-redbubble/ Link to our Discord server for all to join - discord.gg/NuvSY9K Follow us at: twitter.com/MagicBeansCast facebook.com/magicbeanscast twitch.tv/magicbeanscast Email us at magicbeanscast@gmail.com On Twitter we are: Shorty - @pieceinc Cracker - @joelhill_ Chewy - @chewyMTG Stu - @emstuie Chris - @pollywafflemtg Scott- @therealblasta
This week we discuss what is a MUTOA, MUTOA vs Consolidation Point, best way to splice ribbon fiber into a Corning Cassette, being paid for stand by time, high/low settings on punch tool and so much more Support the show
Episode 199 – Eternal Information – Part 7 – Living Information 2 Welcome to Anchored by Truth brought to you by Crystal Sea Books. In John 14:6, Jesus said, “I am the way, the truth, and the life.” The goal of Anchored by Truth is to encourage everyone to grow in the Christian faith by anchoring themselves to the secure truth found in the inspired, inerrant, and infallible word of God. Script: By faith we understand that the entire universe was formed at God’s command, that what we now see did not come from anything that can be seen. Hebrews, chapter 11, verse 3, New Living Translation ******** VK: Hello! I’m Victoria K. Welcome to Anchored by Truth brought to you by Crystal Sea Books. Thank you for joining us here today on Anchored by Truth. For several episodes we have been doing a series we call “Eternal Information.” We’ve covered a lot of ground so far in this series. For those listening today who may have missed some of the earlier episodes we encourage you to go to our website crystalseabooks.com where you can hear them. And, of course, anyone who just wants to review an episode even if they heard it before can always go to crystalseabooks.com for a review. This series in particular has been one of those series where each episode builds on the material from previous episodes. In the studio we have RD Fierro. RD is an author and the founder of Crystal Sea Books. RD, would you like to amplify a little more on what I was just talking about – that this series of Anchored by Truth is a series where we are steadily building on what came before? RD: Sure. But before I do that I would also like to extend my greetings to everyone who is joining us here today. I suspect most listeners are probably like me. When I first came across the concept of information as one more way in which God’s presence in the universe is manifest I was completely unfamiliar with it. Like all listeners, I used information everyday throughout the day. But I never gave any thought about information itself. Information was kind of like air. It was just there. But I never stopped to think about how it got there. Then I came across Dr. Werner Gitt’s book entitled In the Beginning was Information and I had one of those “light bulb” moments. The presence of information requires the presence of intelligence and there is no way we can avoid living in this universe and avoid the fact that it contains information. But to try to communicate all that this concept involves isn’t easy. Unlike some subjects where we connect with them easily digging deeper into how information functions within the universe requires a lot of … well, information. VK: Studying information requires a lot of information. I’m not sure if that is profound or just redundant … RD: Probably a little of both. At any rate there are a lot of ideas that are tied up in thinking about how information again assures us that there must be a Designing Mind behind the universe as we know it. So, we began unpacking those ideas one at a time. VK: Such as the fact that information is an essential component of the universe that we know. Unlike other components with which we are more familiar like matter and energy information stands apart in the way in which it presents itself. Information is non-material. It is not dependent for its existence on matter or energy but matter and energy can be used to transmit, receive, or store it. The same keyboard, wires, and screens can exchange recipes for pies, maps to buried treasure, or diagrams for making bombs. The information doesn’t change the plastic, copper, or silicon in the keyboard or screen. But neither is the plastic, copper, or silicon responsible for the content of the information. These aren’t the kind of ideas we think about everyday. RD: Right. And those ideas are just the beginning of what we had to undertake. And the specific idea that we have been pursuing for the last couple of episodes of Anchored by Truth is that the presence of information in living creatures is undeniable. A couple of episodes ago we spent some time on the basics of biochemistry and last time we began our dive into the most information storage system on the planet: DNA. VK: So, today we want to finish that discussion. But just as a brief recap last time we began covering the fact that DNA is actually a four-dimensional information storage system. Just about every information system invented or used by man is one-dimensional. When we transmit information through written text we get the information by reading the text from left to right. And even though there are some writing systems like ancient Hebrew that are read right to left the same observation applies. We get the information by going in one direction. Try to read the same text backward and all you get is gobbledygook. But as we began showing last time DNA doesn’t just store and transmit information in one dimension or in one direction. DNA does so on multiple levels. RD, why don’t you briefly remind us of what we covered when we went over the first three dimensions in which DNA stores information? RD: And DNA is built from compounds called nucleotides. Nucleotides consist of a sugar, a nitrogen containing base, and a phosphate group. There are 4 bases that comprise the structure of DNA: adenine [a-duh-neen], guanine [gwaa-neen}, cytosine [sai-tuh-seen], and thymine [thigh-mean]. They are usually abbreviated A, G, C, and T. So, these are the “letters” of the genetic alphabet. And DNA is made up of two long strands – the famous double helix – joined by means of the associations: A with T and C with G. This means that the two strands are complimentary. One of the key takeaways about DNA is that DNA’s information function is not dependent on its chemistry. Just as the chemistry of ink and paper do not determine the information that is present on a printed page, the chemical components that comprise DNA do not determine the messages that it stores and sends. So, the first level of information that DNA contains is simply the order of the “letters” – the nucleotide base pairs. The entire human genome has been mapped. So, we know the order of the letters for it. The first 15 letters of DNA in the human “Y” chromosome are “CTAACCCTAACCCTA.” VK: So, this first level of information is just a sequence of letters. That seems pretty simple. But you start to get a hint of the other levels of information when you realize that we have between 20,000 and 25,000 genes but our bodies produce over 100,000 different proteins. Some estimates are that the human body produces over 300,000 distinct proteins. If the sequence of the letters in DNA is the first level of information, what is the second level? RD: The second dimension of the genome deals with the way one section of DNA interacts with another section. It’s easy enough to create a visual depiction of the first dimension of DNA. It is essentially just a long sequence of the letters A, C, T, and G. But trying to draw a pictorial representation of the second dimension would be a dizzying array of lines and arrows connecting different parts of the linear string of DNA. At first when scientists discovered DNA and genes they thought they had discovered the key to a lot of biological mysteries. One of the key ideas that emerged into science was the idea that one gene coded for one protein. Proteins are, of course, the molecular machines of life. VK: But that idea was too simple wasn’t it, especially for higher organisms? As we mentioned earlier the human body produces far more different proteins than we have genes. RD: Yes. The linear left to right read of DNA coupled with the idea that each gene, essentially a subsection of DNA, coded for one protein turned out to be far too simplistic. For instance, our protein genes are broken up into a series of “exons” (the parts that code for protein) and “introns” (non-coding intervening sequences). To make a protein, the gene is first transcribed into RNA, then the introns are spliced out, the exons are stitched together, and the remainder is translated into protein. That might seem straightforward. But we now know that some proteins are manufactured through a process called “alternate splicing”, where exons from different locations in the genome are combined to create many different proteins. In fact, we have learned that alternate splicing is so pervasive that the definition of the word “gene” as it was originally conceived had just about lost its meaning. The one gene-one enzyme hypothesis turned out to be a gross oversimplification. VK: Biologist Dr. Robert Carter has said this about the second informational dimension of DNA. “The second dimension deals with things like specificity factors, enhancers, repressors, activators, and transcription factors. These are proteins that are coded in the DNA, but they move to another part of the genome after they are made and turn something on or off. But there are additional things happening in this dimension.” In other words there’s a lot of information that DNA supplies to the body that isn’t tied to a simple left to right reading of the letters. There are connections being made between different sections of the DNA that are also necessary for life. RD: Yes. As I said last time, trying to pictorially represent the information connections within DNA would be so complicated it would be as if you were standing in the midst of a galaxy with beams of light zinging among the stars. There would be so many beams connecting various stars you wouldn’t be able to count them all. And we still are only talking about the second dimension of DNA that supplies information. The third dimension has to do with how DNA is actually stored within the body. The body doesn’t store DNA as a long string. It couldn’t. The DNA is coiled into a very precise 3-D shape. VK: Dr. Carter has also written that, “The third dimension [of information] deals with how the shape of the DNA molecule affects the expression and control of different genes. We have learned that sections of DNA that are buried deep within the coiled-up DNA cannot be activated easily. So genes that are used often are generally easily accessible. Thus, when God wrote out the information in the genome along that one-dimensional strand, He intentionally put things in a certain order so that they would be in the correct place when the DNA was folded into a 3-D shape.” RD: Yes. It would be extremely impractical for the body to store DNA in a linear state. We talked about the amazing fact that the DNA in a single cell would be about 6 feet long if it were laid out in a straight line. It would be extremely thin but it would stretch for 6 feet. The National Institutes for Health have estimated that the DNA present in a human body would be over 67 Billion miles long if all the strands were laid end to end – that’s the equivalent of 150,000 trips to the moon – and back. To store all that DNA the body coils it in tight coils that fit within the nuclei of the various cells. And we now know that genes that are used together are generally found next to each other in the 3 dimensional storage arrangement even when those genes are found on different chromosomes. VK: Last time we used the example of a homeowner organizing his garage. A wise homeowner is likely to organize the garage so the garden shears are close to the rakes rather than with the Christmas light strings and nativity set. The homeowner does this it is because the homeowner knows and understands the use of the things they are storing. In putting things away in the garage they are applying information and intelligence. So, the first dimension of information storage in DNA is the order of the letters. The second is how various sections of DNA actually act in concert with other sections. And the third is how the DNA functions in its 3-dimensional configuration not just as a linear string. RD: Exactly. Well our time ran out last time before we could get to the 4th dimension of the information that DNA contains. VK: Which is …? RD: Time. VK: Time? RD: Time. As incredible as it might seem we now know that the way DNA performs its function changes as time goes by and we know that these changes occur in all the other dimensions. Dr. Carter has written “The shape (3rd dimension), interaction network (2nd dimension), and the sequence of letters (1st dimension) all change. This so far outstrips even our most modern computers that the analogy isn’t even fair anymore.” Dr. Carter gives this example. “We know that different liver cells have different chromosome counts. This is due to the fact that the liver needs lots of copies of certain genes that are involved in metabolism and detoxification. Instead of filling the genome with many copies of these genes, the liver just makes copies of them for its own use. We also know that different brain cells have different number and locations of various transposons.” VK: Transposons are segments of DNA which are capable of moving within or among chromosomes. Transposons were once thought by evolutionists to be “jumping genes” that were leftovers from ancient viral infections. But they’re not. Transposons are vital for the development of the human brain. In other words, our genome is able to dynamically reprogram itself. As Dr. Carter wrote, “This is something that computer scientists have long struggled with. How can you make a self-modifying code that does not run out of control?” RD: So, as amazing as the first three dimensions of DNA’s information are in some ways the 4th dimension truly seems like something out of science fiction. As we go through life our DNA reprograms itself to adapt for where we are in life. It’s hard sometimes to remember that we are talking about a group of atoms and molecules that are present in the nucleus of every one of our 30 to 40 trillion cells. Now again, let’s not lose sight of the basic point. The alternate hypothesis that is offered to Biblical creationism is blind and random chance. VK: Those people who reject the existence of God, and in particular the God of the Bible, must conceive of the world and universe as being composed of matter, energy, time, and space. But no one sees time and space as possessing creative capacity so they are really down to matter and energy. So, their concept for the origin of DNA is that at one point some hydrogen, oxygen, nitrogen, and carbon atoms fortuitously collided and started making some simple organic compounds. Some of these organic compounds ran into each other and poof some simple amino acids or nucleotides were produced. Then these extremely elementary organic collections ran randomly and accidentally collected in one place and all that jostling about produced a string of DNA which contains, at a minimum, millions of atoms. The more you talk about it the more far-fetched it seems. RD: It seems far-fetched because it is far-fetched. And it’s not like evolutionists don’t realize the problems their scenario involves they do. So, they try to craft solutions such as saying that there are unseen “organizing forces” present within physics and chemistry that overcome most of the seeming impossibilities. And there have been extensive computer simulations offered with supposedly random substitutions occurring in strings of letters that show that with enough time and chemical components just the right set needed will emerge. But one basic problem with all these attempts is that they start with a huge amount of information about how life functions today. They ignore the fact that undirected matter and energy would have none of that. Moreover, undirected matter and energy would have no goal of producing life. The evolutionary apologists always start with their own goal of showing how it might be possible. But that’s quite a different thing from showing how it actually occurred. VK: As we often point out on Anchored by Truth explaining the origin of a thing is quite different from explaining its operation. We know today much about how life operates. We know the chemical elements involved. We know the structure of organic compounds and how those compounds can link up and form the ever increasingly complicated structures used by all living things. But an ocean of chemicals just drifting about knows none of that. RD: And I should emphasize at this point that this discussion that we have had about the four dimensional nature of the information DNA contains has only skimmed the surface. I would highly recommend listeners going to the website for Creation Ministries International and spending some time there reading the various articles on DNA. There’s a lot more to DNA than we have time to discuss in this series. VK: Such as? RD: Such as the fact that DNA has its own repair system. VK: Wikipedia says this about the DNA repair system. “DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. In human cells, both normal metabolic activities and environmental factors such as radiation can cause DNA damage, resulting in tens of thousands of individual molecular lesions per cell per day. Many of these lesions cause structural damage to the DNA molecule and can alter or eliminate the cell's ability to transcribe the gene that the affected DNA encodes. … As a consequence, the DNA repair process is constantly active as it responds to damage in the DNA structure.” RD: The DNA repair system is just another facet of DNA that defies explanation by evolutionary development. Without the repair system DNA would quickly be damaged so badly that normal cellular replication would cease. That means death for the organism. So, DNA needs the repair system to keep functioning but it is the DNA itself that tells the body how to produce the repair system. And we have only discovered this very recently. The 2015 Nobel Prize in Chemistry was awarded to Tomas Lindahl, Paul Modrich, and Aziz Sancar for their work on the DNA repair processes. VK: So, what else do you want to cover for today? RD: I want to give our listeners a very inexact model for DNA’s amazing information system. Imagine that you found a long sheet of paper that contained a lengthy list of ingredients for a meal. As you examined the list you realized that it was a list of ingredients for an amazing 7 course meal. At the bottom of the sheet the final line said “roll this into a 2 inch tube.” After you did so you found out that the letters that are now on the outside of the rolled sheet gave you all the steps in preparing the ingredients – the chopping, slicing, dicing, grating, etc. Then the final instruction said “hold near the stove.” And when you did so you found out that certain portions of the letters were now lit up and they gave you precise instructions for cooking the various ingredients like temperature, time, basting, stirring, etc. The last line of illuminated letters now said, “place near the completed dishes.” And when you did that you found out that different letters were now lit up which told you how to garnish, arrange, put on final toppings, and serve. You get the idea. No human technology would permit us to create an information storage system that sophisticated yet we’re asked to believe that random chance built a biological information system that contains hundreds of millions of ingredients. Our most elegant examples of technology and advanced design pale in comparison to the complexity present to every strand of DNA on the planet. Yet, the most amazing thing is that some people continue to insist that all of that sophisticated complexity could have arisen by chance. VK: Well, all that has made me a little hungry but it does make the point. We’re familiar with single dimension information systems because that’s what we experience in our daily lives. Probably, with a lot of effort and planning, we might create a single system that has multiple dimensions of information. But those systems certainly wouldn’t run into the billions of letter or symbols that served multiple tasks simultaneously. The sophistication of DNA eludes us even now. The only reasonable explanation for DNA’s relentless display of information sophistication is because it was prepared and created by the Ultimate, Infinite Designer. It’s just a little bit silly to believe that unintelligent and undirected matter and energy could produce DNA when even the most intelligent scientists could not do so. But God could and that’s what our opening scripture from Hebrews tells us. This sounds like a time to go to God in prayer. Since our children are back in school and busily working their way through the academic year, today let’s listen to a prayer for all of them who could benefit from a little divine help with upcoming tests. ---- PRAYER FOR TAKING A TEST VK: We’d like to remind our audience that a lot of our radio episodes are linked together in series of topics so if they missed any episodes or if they just want to hear one again, all of these episodes are available on your favorite podcast app. To find them just search on “Anchored by Truth by Crystal Sea Books.” If you’d like to hear more, try out crystalseabooks.com where “We’re not perfect but our Boss is!” (Bible Quote from the New Living Translation) Hebrews, chapter 11, verse 3, New Living Translation The human genome is amazingly complex (creation.com) Four Dimensional Genome (creation.com) Splicing and dicing the human genome (creation.com) We are less than dust (creation.com) Epigenetics challenges neo-Darwinism (creation.com)
Exposing neurons to valproic acid, a well-known environmental risk factor for autism, disrupts their ability to generate different proteins from the same gene.
Exposing neurons to valproic acid, a well-known environmental risk factor for autism, disrupts their ability to generate different proteins from the same gene.
Episode 198 – Eternal Information – Part 6 – Living Information Welcome to Anchored by Truth brought to you by Crystal Sea Books. In John 14:6, Jesus said, “I am the way, the truth, and the life.” The goal of Anchored by Truth is to encourage everyone to grow in the Christian faith by anchoring themselves to the secure truth found in the inspired, inerrant, and infallible word of God. Script: For every house is built by someone, but God is the builder of everything. Hebrews, chapter 3, verse 4, New International Version ******** VK: Hello! I’m Victoria K. Welcome to Anchored by Truth brought to you by Crystal Sea Books. Thank you for joining us here today on Anchored by Truth. For several episodes we have been doing a series we call “Eternal Information.” We do series like Eternal Information to help people focus on a foundational truth about the universe we see around us. The universe exhibits order and design. Albert Einstein recognized this simple fact and famously said, “The most incomprehensible thing about the Universe is that it is comprehensible.” Other scientists have noted that the universe displays all the elements that we see in the best manufacturing systems that we have today. The same pieces and parts are used to build structures as diverse as snowflakes, galaxies, stars, and puppy dogs. To help us explore even more about the marvel that is the universe and especially life, today in the studio we have RD. RD is an author and the founder of Crystal Sea Books. RD, the universe is amazing isn’t it? RD: Yes, it is. The universe is so consistent in how it works that we can analyze the composition of stars that are billions and billions of miles away from our little earth. There is no way we could do that unless we knew that the same constituent parts that make up our sun, our earth, and even our bodies were also present in all the other parts of the universe. And that’s the reason that we wanted to undertake this series on eternal information. Just think about it for a second and you quickly realize that the presence of design requires a designer. The presence of organization requires an organizer. Yet this is the very thing that atheists and radical secularists exclude a priori. Why would they do this? There’s only one reason. It’s not that they don’t realize that God exists. They do. All people do. It’s that they don’t like the implications of acknowledging that existence. Because it would mean they would have to make changes to their lives and worldview. VK: So, today we want to go more deeply into the order and design that are present in living creatures. We began this discussion last time on Anchored by Truth when we did a high level overview of some of the basic elements of biochemistry. And in that discussion we noted that the basic unit which is present in all living things is a cell. Some cells have a nucleus and some don’t. But all living things are comprised of cells. And cells, despite their tiny size, are exceedingly sophisticated structures. Anyone who has ever contemplated the properties of a living cell for even a moment has to recognize that human beings still do not have the ability to create structures or systems with that level of design finesse. Our most elegant examples of technology and advanced design pale in comparison to the complexity present to every cell on the planet. Yet, the most amazing thing is that some people continue to insist that all of that sophisticated complexity could have arisen by chance. I heard someone say once that its far more likely you could put butter, eggs, sugar, and milk in a bowl, leave it in the sun, and wait for it to turn into a cake than expect the first cell to have come together by chance. RD: Right. The right ingredients are necessary to make a cake but not sufficient. Making cakes takes information – a recipe. And it takes a chef who will apply the recipe – correctly! And today we’re going to continue to pointing to other evidence that shows the absurdity of believing that random and chaotic activity could generate an integrated structure that has more than 100 billion subordinate parts. VK: A lot more ingredients than it takes to make a cake … RD: True dat – and all those ingredients must be present in just the right places and just the right amounts for life to be possible. Today we want to do an in-depth look at the most amazing information storage medium on the planet – DNA. We’re doing this because we want people to have facts that run directly counter to the assertion that random chance could have produced living creatures. VK: Well, just as a brief review to set the stage – we have already learned several critical things about the biomolecular structure of living things. As you said, the basic structure of all life on earth, whether plant or animal, is a cell. Some creatures like bacteria are only a single cell. Human beings contain over 35 trillion cells. Regardless of the number all life on earth is cellular based. Cells are composed of permeable membranes that encase the components of the cell that actually carry on the business of life. Those components include protein “machines” and nucleic [NU-CLAY-ICK] acids. The most famous nucleic acid is, of course, DNA. Proteins are built from organic compounds called amino acids. Amino acids are small compounds consisting of 10 to 20 atoms. There are hundreds of known amino acids but only 20 of those are used by living creatures. RD: And DNA is built from compounds called nucleotides [NU-KLEE-O-TIDES]. Nucleotides consist of a sugar, a nitrogen containing base, and a phosphate group. The nucleotides of DNA are linked together through their phosphate group and they differ only in the structure of their nitrogen containing base. Specifically, there are 4 bases that comprise the structure of DNA: adenine [a-duh-neen], guanine [gwaa-neen}, cytosine [sai-tuh-seen], and thymine [thigh-mean]. They are usually abbreviated A, G, C, and T. So, these are the “letters” of the genetic alphabet. For chemical reasons the adenine in DNA tends to form an association with thymine and guanine forms an association with cytosine. And DNA is made up of two long strands – the famous double helix – joined by means of the associations: A with T and C with G. This means that the two strands are complimentary. From a DNA standpoint the simplest form of life that lives independently is a bacterium known as mycoplasma genitalium. It has about 500,000 base pairs in its DNA strand. Human beings by contrast have 3 Billion base pairs in our DNA. VK: So, DNA even at its simplest is not a simple structure. I think a lot of people are misled by the fact that we are talking about things that are so small they can only be seen by sophisticated microscopes. I think some people associate small size with simplicity. But with respect to DNA that’s not true at all, is it? RD: No. We must get away from thinking that just because DNA is incredibly small from a visual standpoint that somehow its small size reflects the level of complexity that is represented in its structure. If anything we should marvel that something so small can have so many separate subunits that each has its own place and function. So, today I want to focus on the fact that DNA is a 4 dimensional information storage system. There’s a great article about this on creation.com which is the website for Creation Ministries International. One of the key takeaways from this article, as well as many other articles that are on their website, is that DNA’s information function is not dependent on its chemistry. Just as the chemistry of ink and paper do not determine the information that is present on a printed page, the chemical components that comprise DNA do not determine the messages that it stores and sends. VK: That’s a pretty radical thought but it was one which Dr. Jonathan Sarfati told us about when he was a guest on Anchored by Truth. Paper and ink have chemical elements that form them, and permit them to be useful to store and communicate information but the pen and ink don’t control the information. It requires intelligence to use that paper and ink to store or transmit information. This is the same thing that occurs with DNA. And it comes as a surprise to most people. RD: Yes. We are so surrounded by the pseudo-scientific narrative that life arose randomly from inanimate matter that even most Christians are beguiled thinking that our bodies are the product of matter and energy. It can come as a bit of a shock to realize that we are the product of so much more. The way that DNA functions is a perfect example of that. The first level of information that DNA contains is simply the order of the “letters” – the nucleotide base pairs. The first 15 letters of DNA in the human “Y” chromosome are “CTAACCCTAACCCTA.” The entire human genome has been mapped. VK: Now just about everyone has heard about “genes” and most people know that genes control inherited characteristics. A gene is a small section of DNA that contains the instructions for a specific molecule, usually a protein. The purpose of genes is to store information. Each gene contains the information required to build specific proteins needed in an organism. The human genome contains 20,687 protein-coding genes. Genes come in different forms, called alleles. The genes for blue eyes and brown eyes obviously code for the same characteristic, eye color. But the genes for brown eyes and blue eyes are different. So, they would be alleles. RD: So, this first level of information is just a sequence of letters. That seems pretty simple. But you start to get a hint of the other levels of information when you realize that we have between 20,000 and 25,000 genes but our bodies produce over 100,000 different proteins. Some estimates are that the human body produces over 300,000 distinct proteins. VK: Twenty thousand genes seem like a lot but it was actually a much lower number than expected. The low number of genes in the human genome was troubling for several reasons. First, it meant that human beings did not have that many more genes than organisms that were much simpler. Second, it meant we were creating a great many proteins from relatively few genes. Scientist had no idea how this could be done on such a large scale. And third, the complexity of the human genome just kept multiplying the barriers to envisaging how such sophistication could arise by random and chaotic forces. RD: When science first discovered genes they thought they had discovered the secret that solved the mystery of how one generation passed various traits to another. Scientists initially saw the gene as the master controller that regulates the outward expression of the attributes of an organism. This idea was popularized in Richard Dawkins’ book, The Selfish Gene. But that initial model turned out, as so often happens with God’s creation, to be far too simple. It had become conventional wisdom to say that any characteristics we acquire during our lives cannot be passed to our kids. But we now know that while this idea was partially true, it is an incomplete truth. In fact, there are times when characteristics acquired by a parent are passed to a child and there is now an entire branch of study called “epigenetics” to understand how this happens. But the idea that the outward interactions of an organism with its environment might pass information back to the genome, or even just affects how the genome performs its function was completely rejected for decades. Then came the science of what is now called epigenetics. VK: The CDC defines epigenetics as the study of how your behaviors and environment can cause changes that affect the way your genes work. Marc Ambler who was on the board of Creation Ministries International said “[Epigenetics] poses a profound challenge to evolution because it suggests that latent genetic information of sorts is sitting in the DNA waiting for a particular environment in order to be switched on or off. It is like information in a book with certain pages stapled together, only to be opened and the information acted upon in certain environmental circumstances. If evolution occurs by natural selection, via the environment culling or conserving the effect of random mutations, how can there possibly be a ‘suite’ of genetic information just waiting there to be switched on by an environment to which the organism has yet to be exposed?” RD: Yes. Now I just to remind everyone what this discussion is all about. The fact that a single gene may code for more than one protein and that our DNA may be affected by our environment is strongly suggestive of the fact that the first level of information in DNA – the sequence of the letters – does not tell the whole story. At first, after the initial discover of DNA, scientists thought they had the key to whole biological puzzle. The idea was that if we could just “learn the code” – in effect figure out the sequence - we could perform miracles. That’s why scientists petitioned the US government in the 1990’s to fund the sequencing of the human genome. And they did. And after doing so we found out that the sequence of the letters in human DNA was only the beginning of understanding DNA. Because DNA is far more complicated than just its very complex sequence of letters. VK: So, if the sequence of the letters in DNA is the first level of information, what is the second level? RD: The second dimension of the genome deals with the way one section of DNA interacts with another section. It’s easy enough to create a visual depiction of the first dimension of DNA. It is essentially just a long sequence of the letters A, C, T, and G. But trying to draw a pictorial representation of the second dimension would create a dizzying array of lines and arrows that connect different parts of the linear string of DNA. The depiction would be so complicated it would be as if you were standing in the midst of a galaxy with beams of light crossing across one another. VK: Biologist Dr. Robert Carter has said this about the second informational dimension of DNA. “The second dimension deals with things like specificity factors, enhancers, repressors, activators, and transcription factors. These are proteins that are coded in the DNA, but they move to another part of the genome after they are made and turn something on or off. But there are additional things happening in this dimension. During the process of protein manufacturing, a gene is “read” by the cell during a process called transcription. Here, the DNA is copied into a molecule called RNA. The RNA is then translated into a protein. …But in a process called post-transcriptional regulation, the RNA can be inactivated or activated by other factors (like [micro RNAs]) coded elsewhere in the genome. ... One of the greatest mysteries is how only about 22,000 genes can produce more than 300,000 distinct proteins. The answer is that the cell goes through a process called alternate splicing, where the genes are sliced and diced and different parts are used by different cells at different times and under different circumstances to produce the many different proteins. This incredibly complex process is just one part of that second dimension of the genome.” RD: The complexity the first dimension of DNA helps put to rest the idea that the chemical structure of DNA is what controls DNA’s function within a cell. Well, if the first dimension began the process, the second dimension of information contained within DNA puts a stake in its heart. Simply put, human beings have not been able to create any information systems that have this level of complexity and interactivity. We are well familiar with information systems like written communication that transmit information be reading something from right to left or left to right. But to create an information system where information is not only derived from reading each letter or word in one direction but where that system provides meaningful information connecting every 5th word, 10th word, and 20th word would boggle our minds. Yet even this isn’t the end of the information that resides within DNA. There are still more dimensions. VK: Dr. Carter has also written that, “The third dimension deals with how the shape of the DNA molecule affects the expression and control of different genes. We have learned that sections of DNA that are buried deep within the coiled-up DNA cannot be activated easily. So genes that are used often are generally easily accessible. Thus, when God wrote out the information in the genome along that one-dimensional strand, He intentionally put things in a certain order so that they would be in the correct place when the DNA was folded into a 3-D shape.” RD: Yes. Like most components of the cell it would be extremely impractical for the body to store DNA in a linear state. The DNA in a single cell would be about 6 feet long if it were laid out in a straight line. It would be extremely thin but it would stretch for 6 feet. The National Institutes for Health have estimated that the DNA present in a human body would be over 67 Billion miles long if all the strands were laid end to end – that’s the equivalent of 150,000 trips to the moon – and back. To store all that DNA the body coils it in tight coils that fit within the nuclei of the various cells. Therefore, in the human body DNA is found in a 3 dimensional shape not a straight line which would be 2 dimensions. This adds complexity to the issue of how the body can acquire the information stored in the genes that are on the DNA. As Dr. Carter mentioned we now know that the genes that are used most often are stored on the outside of the 3 dimensional structure where they are most easily accessible. Moreover, sometimes as we’ve alluded to above the various genes sometimes operate in cooperation with other genes. Well, we now know that genes that are used together are generally found next to each other in the 3 dimensional storage arrangement even when those genes are found on different chromosomes. VK: It’s like a homeowner who is organizing his garage. In the garage they may have some items they use in the garden, some that are used for home repairs, some that are needed for the cars and trucks, and maybe some that they only need once a year like the Christmas decorations. A wise homeowner is likely to organize the garage so the garden shears are close to the rakes rather than with the Christmas light strings and nativity set. But it goes without saying that when the homeowner does this it is because the homeowner knows and understands the use of the things they are storing. In putting things away in the garage they are applying information and intelligence. And, in fact, the storage system that is represented in how DNA is stored within a cell is far more complicated that even the storage system used in the largest industrial warehouses. RD: Exactly. We still need to talk about the 4th dimension of information that is found in DNA but since we’re running out of time I want to give our listeners a very inexact model for DNA’s amazing information system. Imagine that you found a long, thin plastic tube. As you examined the tube you realized that written on the outside in letters that spiraled around the tube was a list of ingredients for an amazing 7 course meal. At the bottom of the tube the final line said “twist this tube 3 times.” After you did so you found out that the letters now gave you all the steps in preparing the ingredients – the chopping, slicing, dicing, grating, etc. Then the final instruction said hold near the stove. And when you did so you found out that certain portions of the letters now gave you precise instructions for the cooking. The last line of illuminated letters now said, “place near the completed dishes.” And when you did that you found out that different letters were now lit up which told you how to garnish, arrange, put on final toppings, and serve. You get the idea. No human technology would permit us to create an information storage system that sophisticated yet we’re asked to believe that random chance built a biological information system that is thousands or millions of times more elegant. VK: Well, all that has made me a little hungry but it does make the point. We’re familiar with single dimension information systems because that’s what we experience in our daily lives. Probably, with a lot of effort and planning, we might create a single system that has multiple dimensions of information. But those systems certainly wouldn’t run into the billions of letter or symbols that served multiple tasks simultaneously. The sophistication of DNA eludes us even now. The only reasonable explanation for DNA’s relentless display of information sophistication is because it was prepared and created by the Ultimate, Infinite Designer. It’s just a little bit silly to believe that unintelligent and undirected matter and energy could produce DNA when even the most intelligent scientists could not do so. But God could and that’s what our opening scripture from Hebrews tells us. This sounds like a time to go to God I prayer. Since our children are back in school and busily working their way through the academic year, today let’s listen to a prayer for all of them who could benefit from a little divine help with upcoming tests. ---- PRAYER FOR TAKING A TEST VK: We’d like to remind our audience that a lot of our radio episodes are linked together in series of topics so if they missed any episodes or if they just want to hear one again, all of these episodes are available on your favorite podcast app. To find them just search on “Anchored by Truth by Crystal Sea Books.” If you’d like to hear more, try out crystalseabooks.com where “We’re not perfect but our Boss is!” (Bible Quote from the New International Version) Hebrews, chapter 3, verse 4, New International Version The human genome is amazingly complex (creation.com) Four Dimensional Genome (creation.com) Splicing and dicing the human genome (creation.com) We are less than dust (creation.com) Epigenetics challenges neo-Darwinism (creation.com)
I'm joined by guests Calle, Roy, Rijndael & t-bast to discuss Bitcoin lightning. Discussion Topics 00:04:08 Lightning implementations 00:11:04 LN URL 00:14:45 Protocols and different implementations 00:19:10 Wallet interaction with base chain 00:25:41 Splicing 00:34:26:06 Cost of liquidity and opening/closing channels 00:39:07 Monetization 00:49:12 Compatability and LSPs 00:56:08 Incentives to monopolize 01:04:43 Attacks on lightning 01:10:20 Cashu & eCash 01:41:42 Competing L2s and alternative lightning networks 01:44:19 Security Links & Contacts: Website: https://bitcoin.review/Podcast Twitter: https://twitter.com/bitcoinreviewhq NVK Twitter: https://twitter.com/nvk Telegram: https://t.me/BitcoinReviewPod Email: producer@coinkite.com LN Address:⚡nvk@getalby.com (not an email!) Full show notes: https://bitcoin.review/podcast/episode-15/
Sturm and Mikey cover Jabba's Kit, GAC, the Splicing of Mods and their views on this. DataCrons, Omni's and Sturm teaches Mikey the new search engines for mods. Did Mikey unlock Malgus or does he suck that bad? More importantly IS STURMBOCK STEPPING AWAY FOR GOOD!? All comments are read and discussed. The PEOPLE have spoken.
In this episode Professor Harries discuss whether RNA Splicing meets the criteria of a hallmark of aging. To qualify it should i) manifest during normal aging ii) its aggravation should accelerate aging and iii) it amelioration should slow or reverse aging. Prof Harries goes through each of these criteria with respect to RNA splicing. Lorna Harries is Professor of Molecular Genetics at the University of Exeter College of Medicine and Health where she leads the RNA-mediated disease mechanisms group. Her group has interests in messenger RNA processing and epigenetic gene regulation in the context of ageing and chronic disease. She is a Co-Founder & the Chief Scientific Officer for SENISCA (www.senisca.com), a senotherapeutics company. Her team were the first to report dysregulation of alternative splicing as a new, and druggable, hallmark of ageing. With that, let me start the interview. Professor Harries site at University of Exeter https://medicine.exeter.ac.uk/people/profile/index.php?web_id=Lorna_Harries Senisca home page https://www.senisca.com/ If you would like to support our channel, we'd love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan 15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15. Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/ 10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/
In this episode Professor Harries addresses some of the fundamental questions about RNA splicing and how it regulates gene expression Lorna Harries is Professor of Molecular Genetics at the University of Exeter College of Medicine and Health where she leads the RNA-mediated disease mechanisms group. Her group has interests in messenger RNA processing and epigenetic gene regulation in the context of ageing and chronic disease. She is a Co-Founder & the Chief Scientific Officer for SENISCA (www.senisca.com), a senotherapeutics company. Her team were the first to report dysregulation of alternative splicing as a new, and druggable, hallmark of ageing. With that, let me start the interview. Professor Harries site at University of Exeter https://medicine.exeter.ac.uk/people/profile/index.php?web_id=Lorna_Harries Senisca home page https://www.senisca.com/ If you would like to support our channel, we'd love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan 15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15. Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/ 10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/
Stacey digs into General Motors' announcement about the new upcoming hybrid and electric corvettes, should you splice two vehicles together and the pros and cons of the Biden administration's plan to allow the use of E-15 gas year round.
UFC 273 is in the books and the fellas recap a great weekend of fights. Splicing between a 9-hole golf round, and some tri-tip endeavors on the Traeger, the lads sprinkle in some upcoming fight talk, specifically the Belal v. Luque main event this weekend at UFC Apex. Cain Velasquez released a statement on his Instagram account today, the fellas touch on that, as well as address Ground Controls own Jesse Stirn with his upcoming Art of Scrap bout in Indiana this weekend. Please send us your clean work bits from the week.Links below for Jesse and his fight. See too Mike Mallot's post fight mention of Joey Rodriguez's daughter battling cancer, and his promise to give his win money donation to his coach's daughter hopeful swift recovery.Angies Gofundme: https://www.gofundme.com/f/help-angie-ko-cancerLink to Jesses Fight: https://www.artofscrapfights.com/
If you know about The Matrix, you know there are beings who control it - the “Agent Smiths” or the Archeons. We know this. We know we are farmed for our energy (if you don't know, listen to episode 4 - Your Emotional Labor - A Labor of Love or Emotional Bondage?).But I've never heard any theories on how they do this. Until now.They break us down, break us apart, mix us up, then reinsert us into The Matrix. Everything is designed to keep us confused, angry, questioning ourselves, and self-loathing.But knowledge is power and the first step to awakening is awareness. So here you go: this is how they've kept us trapped for eons. And if we're not willing to explore, detach, and expand, then we will stay stuck here in Illusion for eons more. Dimensional ShifterRedditDiscordYouTube (CC)
There are at least 2,500 proteins that bind RNA. Gene Yeo, PhD, MBA, explains how his lab studies these RNA binding proteins and their impact on human health. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37589]
Xenotransplantation is the harvesting of animal organs, including those that are genetically modified, for human subjects. In October 2021, a pig's kidney was successfully transplanted into a person and in early 2022 a GE pig heart was transplanted into a human subject. These technologies and techniques aim to assist those in dire need of organs, of which a few hundred die each year as a result of not receiving a transplant or their body rejecting one. GE organs have been offered as a solution so that the body naturally does not so easily reject them. However, the notion that such experiments are new is only the result of the public lacking contextual data. In 2017 MIT Technology Review reported that there were farms where human organs were being grown inside of animals! That same year scientists confirmed a journal Nature report from the 1980s when they announced the ability they had to alter blastocysts, the precursors of embryos, to prevent the development of certain organs in the body of an animal. Splicing of different species and kingdoms has been conducted since at least the 1970s, and the US and China were conducting the same in 2021. By blurring the line between human and animal, and even insect, such technology could easily be used to alter the human in a way to render it nothing more than an automaton. This could be done without the need to alter embryos too. The creation of an inferior race could be accomplished through the methodologies of a master race using the same technology to make themselves beautiful and more intelligent.
In the last episode on the central dogma of molecular biology, DNA Dan discussed the information flow of DNA, to RNA, to amino acid sequences that make up proteins. In this episode, Dr. Handley discusses proteins - the work horses of the body, and the extensive roles they play in our bodies. By last known count, there are around 20,000 protein coding genes in the human coding genome that make up and operate the human body. How can these 20,000 genes produce over 100,000 proteins? This is where nature, the mad scientist, comes in. ------------------------------------------Join DNA Dan each month as he dives deep into the world of genetics, genomics, DNA, and the future of precision genomic medicine. Dan discusses health and ancestry genetic testing, forensic genetics, genetics and mental health, common myths about genetics, and more. DNA Dan, SCU Professor of Genomics, Dan Handley, M.S., Ph.D., shares his knowledge from his over 30 years of experience in the world of advanced genomics research and biotechnology. Please visit our website for more information about Southern California University of Health Science's Master of Science Program in Human Genetics & Genomics. https://bit.ly/SCU-DNA_Dan
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