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Freeport Maine is practically entirely LL Bean. Pastor Sam was there visiting his family over one Christmas a few years back. He was amazed by it all and had this to say about it. "As I looked up at that tree in Freeport Maine, I was initially struck by its size. Saying it is enormous is an understatement. Though after really examining it, I was more moved by the sheer number of lights on display upon that powerful pine. There were 1000s and 1000s and 1000s casting their luminescence on the night sky! It was a sight to behold. Light has way more important uses than just making our Christmas trees look pretty. Light reveals something, often the way, most notably against a pervasive darkness (which, pervasive darkness is a great way to describe driving around Maine at night)." Background: It is against the darkness of the world that we see the light of Christ shine most brightly. We will see in the gospels of John first and then Matthew, the significance of light and consider some ways that Christmas tree lights remind us of its importance. God's word reminds us of the importance of light. (John 8:12, 9:1-5; Matthew 5:14-16)

The Background:   It's been a long time coming. You've heard me talk about the composition and growth over a few years. Its now time for Ms. Lady owner of Ladies Wicked Playground and our favorite Mistress!   Through our the mini series, we will share the journey of our relationship including all the ups and downs, the good the bad, and all the naughty in between! All relationships take work and lots of communication. Ours is definitely much more complex and you'll begin to understand it all as time goes on. Tune in on Thursday as a new episode in the mini series launches.   If you have any questions about our relationship and want to hear further details on a specific area, email me at MizzyBender@outlook.com   To learn more about Ms. Lady www.lwpvenue.com   Subscribe to www.mizzybender.com to stay up to date on current events and more.

Things get deep in this episode. Stick around as we continue every Thursday until we tell our whole story.   The Background:   It's been a long time coming. You've heard me talk about the composition and growth over a few years. Its now time for Ms. Lady owner of Ladies Wicked Playground and our favorite Mistress!   Through our the mini series, we will share the journey of our relationship including all the ups and downs, the good the bad, and all the naughty in between! All relationships take work and lots of communication. Ours is definitely much more complex and you'll begin to understand it all as time goes on. Tune in on Thursday as a new episode in the mini series launches.   If you have any questions about our relationship and want to hear further details on a specific area, email me at MizzyBender@outlook.com   To learn more about Ms. Lady www.lwpvenue.com   Subscribe to www.mizzybender.com to stay up to date on current events and more.

We still have sooooo much more to go! Episodes 4 and 5 get complicated and real. Tune in every Thursday as Ms. Lady shares her story.   The Background:   It's been a long time coming. You've heard me talk about the composition and growth over a few years. Its now time for Ms. Lady owner of Ladies Wicked Playground and our favorite Mistress!   Through our the mini series, we will share the journey of our relationship including all the ups and downs, the good the bad, and all the naughty in between! All relationships take work and lots of communication. Ours is definitely much more complex and you'll begin to understand it all as time goes on. Tune in on Thursday as a new episode in the mini series launches.   If you have any questions about our relationship and want to hear further details on a specific area, email me at MizzyBender@outlook.com   To learn more about Ms. Lady www.lwpvenue.com   Subscribe to www.mizzybender.com to stay up to date on current events and more.

How Much Money Down Do You Need for an SBA 504 Loan? In this brief video, Beau answers the question, "How much money down do I need for an SBA 504 loan?" The short answer is 10 percent down for business expansion, 15 percent for startups. But it is a little more complex than that. Watch the video to find out more. Background It depends on if it's a business expansion or a startup. The other major factor to note is if it's a special purpose building or property, you get dinged another 5 percent on the LTV (loan to value). Though CDC/504 loans tend to be conflated with real estate, they are really designed for anything that you log under “property, plant, and equipment.” This means you can use them for purchasing or renovating commercial real estate or for purchasing equipment. These are some eligible uses for SBA 504 loans: The purchase of existing buildings The purchase of land and land improvements, including grading, street improvements, utilities, parking lots and landscaping The construction of new facilities or modernizing, renovating, or converting existing facilities The refinancing of debt in connection with an expansion of the business through new or renovated facilities The purchase or upgrade of equipment and machinery You can't use an SBA CDC/504 loan to refinance pre-existing debt or for working capital, so if you're looking for a more versatile loan, then consider the SBA 7(a) loan program.

Background: It’s no surprise that unplanned, emergency intubations are significantly different from intubations in the operating room (OR). Unplanned intubations on the floors and in... The post REBEL Cast Ep99: The INTUBE Study –  Adverse Peri-Intubation Events in the Critically Ill appeared first on REBEL EM - Emergency Medicine Blog.

Background: It has long been thought that intravenous contrast can lead to acute kidney injury. Recent data, however, has called this dogmatic teaching into question. ... The post REBEL Cast Ep98: Intravenous Contrast and Long-Term Kidney Impairment appeared first on REBEL EM - Emergency Medicine Blog.

Space author, journalist and historian Rod Pyle joins Tim to tell the story you knew and the ones you didn’t about the pinnacle accomplishment for the NASA space program, when man first stepped foot on the Moon thanks to Apollo 11, which is celebrating its 50th anniversary in 2019. https://traffic.libsyn.com/shapingopinion/Apollo_11_auphonic.mp3   On July 20th of this year, the country and the world will mark the 50th anniversary since the historic voyage of Apollo 11 when man first stepped foot on the moon. That event market the fulfillment of a promise President John J. Kennedy made in a speech at Rice University on September 12th 1962. In less than seven years, the United States developed the systems, technologies and ability to do something mankind had never before achieved. In 2019 it may be difficult to imagine just how big this was.  You would have to go to history books to read about ancient mariners who discovered never before seen lands and cultures.  Only with Apollo 11 it was different. Man has always been able to see the Moon, but it wasn’t until Apollo 11 that he would actually walk on it. And thanks to the technology of the day, millions around the world were able to see and hear that history in real time, though the imagery left much to be desired. In episode 50, we talked about one of the low points for NASA, which was the Challenger Disaster. In this episode we will talk about the highest of highs for NASA. Rod Pyle has written a book about Apollo 11 called First on the Moon with a forward written by one of the first men on the moon Buzz Aldrin. His book features many stunning photos and illustrations, along with some rarely seen documents that tell the story of the first men on the moon. The Mission Kennedy framed it in that 1962 speech: To beat the Soviet Union in space. National and world security. To set the tone that our mission to space would be in the name of peace, not war. But clearly to gain a military edge. Background It took 400,000 scientists, engineers, technicians and managers along the way. The public was mixed in support of space travel 50/50. Launch was July 16, 1969 from Cape Kennedy. Orbited the Earth for 2 hours and then accelerated to escape Earth’s gravity. Three days later, Apollo 11 entered lunar orbit. The Lunar Module (LM) landed on July 20th. “The Eagle has landed.” The Sea of Tranquility was chosen because it is relatively smooth and level. Armstrong had to manually pilot the LM to avoid a sharp-rimmed crater seconds before landing. The astronauts were supposed to eat and sleep and then walk on the Moon, but they decided to walk on the Moon first. This was planned, but the flight control didn’t all know this. Some had gone home to eat and sleep. They figured it would be easier to decide to walk on the Moon then than to plan to do it then and have to abort. Neil Armstrong was the first to leave the LM. They had a grainy black and white video camera that sent live signals back to Earth. While on the moon, Buzz Aldrin and Armstrong deployed a Solar Wind experiment, collected a sample of lunar dust and rocks, took panoramic photos of the region near the landing site (Sea of Tranquility), and close-up photos. They also deployed a seismic experiment. They left the Moon the next day, and three days later, they splashed down in the Pacific Ocean. The Crew Neil Armstrong – Commander Buzz Aldrin – Pilot of Lunar Module – The Eagle Michael Collins – Command Module Pilot Deke Slayton picked the crews and was against choosing crews for specific missions. His philosophy – any crew could fly any mission. Mission objectives changed often. He picked several different crews for the rough time period of the moon landing and scheduled them. Back-up crew of 7 would fly 10, 8’s back-up crew would fly 11, and so on. There were some changes with the crews of Apollo 8 and 9 led to the make-up of the Apoll...

BACKGROUND: It started 10 years, 2 months and a day ago as I wanted to add a different feature set to my already popular Stogie Fresh website. I was already reviewing cigars, publishing feature-length article on a variety of cigar … Continue reading →

BACKGROUND: It started 10 years ago and now it is a part of history. Last week, on a hot Central Coast weekend, the Doc’s 10th annual Central Coast Herf launched its final hurrah. The 10th annual and final bash drew … Continue reading →

Rachel Gore Freed is Senior Program Leader for Rights at Risk with the Unitarian Universalist Service Committee (UUSC). She is giving you a personal account of what is happening at the 3 Detention Centers in Texas at Dilley and Karnes;  and Berks, Pennsylvania. Rachel will share what you can do to help. Background: It’s not a crime to seek asylum in the United States. Yet, at least 1,500 refugee women, many of whom are mothers, are currently detained in jail-like conditions in Texas and Pennsylvania. Many of these women have passed reasonable fear interviews and have been denied parole. Although bonds are afforded to mothers whose fears of returning to their home countries are found to be “credible” by an asylum officer, neither ICE nor the immigration judges will grant bonds to families passing the “reasonable” fear process (an even higher standard of proof for people not eligible for credible fear interviews). The withholding of bond along with the ICE policy of denying parole to all positive reasonable fear applicants have resulted in excessively long detention of these families. According to U.S. Citizenship and Immigration Services, at least 100 such families are currently being held in family detention facilities located in Karnes and Dilley, Texas, as well as Berks, Penn. On average, these children and their mothers are detained for nine months to one year, with several having already been detained for more than a year. Continuing to detain these women deeply conflicts with our U.S. values, including due process. One of these refugee women is 19 years old and the mother of a four-year-old. She and her child fled Honduras and are now being held inside Karnes County Residential Center. Under the stress of living in detention, she attempted suicide. She is not alone. At the Berks County facility, another young mother — distraught over being detained for 11 months and counting —attempted to end her life. This spring nearly 80 other women detained at the Karnes facility participated in a hunger strike in hopes of bringing attention to their plight. Human rights lawyers and advocates have reported that conditions inside these centers are similar to jail; they expose refugees to trauma, malnutrition, and depression. Standing up for these women and their families is a moral imperative. UUSC video about who they are: Bio: Rachel Gore Freed is a human rights lawyer with a wealth of domestic and international experience. As the Rights at Risk senior program leader, Freed spearheads, plans, and implements UUSC’s work responding to humanitarian crises and advancing the rights of people who are most overlooked or discriminated against in the midst of crises such as forced migration, large-scale conflicts, genocide, and natural disasters. Prior to joining UUSC, Freed litigated several environmental justice suits with the National Environmental Law Center. A passionate civil rights advocate, she previously represented low-income immigrants and detained asylum seekers pursuing relief from unjust deportation in New York City. She has also worked with the List Project on Iraqi refugee policy and served as cochair of the American Bar Association International Refugee Committee. Freed began her legal career clerking with the Charles Taylor prosecution team at the Special Court for Sierra Leone, where she focused on witness protection. In addition, she has worked with the Irish Center for Human Rights, the Center for Reproductive Rights, and the American Society for International Law. Freed holds a bachelor’s degree with a focus in international development from the George Washington Eliot School of International Affairs and a doctor of law degree from Vanderbilt University Law School. Favorite Quote: “To love. To be loved. To never forget your own insignificance. To never get used to the unspeakable violence and the vulgar disparity of life around you. To seek joy in the saddest places.

Background: It is widely recognized that health-related quality of life (HRQL) is impaired in patients with Chronic Obstructive Pulmonary Disease (COPD), but there is a lack of research on longitudinal associations of COPD and HRQL. This study examined the effects of COPD in early stages of disease on HRQL over ten years in a working-age general population setting in Southern Germany while considering the influence of common comorbidities. Methods: In the population-based KORA F4 study (2006-08) 1,321 participants aged 41-61 years performed spirometry and reported information on HRQL (measured by the generic SF-12) and comorbidities. For the same participants, HRQL information was available seven years before and three years after the lung function test from the previous S4 (1999-2001) and the F4L follow-up study (2010). Using linear mixed models, the physical and mental component summary scores (PCS-12 / MCS-12) of the SF-12 were compared over time between COPD groups. Results: 7.8% of participants were classified as having COPD (according to the LLN definition and the Global Lungs Initiative), 59.4% of them in grade 1. Regression models showed a negative cross-sectional association of COPD grade 2+ with PCS-12 which persisted when comorbidities were considered. Adjusted mean PCS-12 scores for the COPD grade 2+ group were reduced (-3.5 (p = 0.008) in F4, -3.3 (p = 0.014) in S4 and -4.7 (p = 0.003) in F4L) compared to the group without airflow limitation. The size of the COPD effect in grade 2+ was similar to the effect of myocardial infarction and cancer. Over ten years, a small decline in PCS-12 was observed in all groups. This decline was larger in participants with COPD grade 2+, but insignificant. Regarding MCS-12, no significant cross-sectional or longitudinal associations with COPD were found. Conclusion: Despite small HRQL differences between COPD patients in early disease stages and controls and small changes over ten years, our results indicate that it is important to prevent subjects with airflow limitation from progression to higher grades. Awareness of HRQL impairments in early stages is important for offering early interventions in order to maintain high HRQL in COPD patients.

Background: It is thought that foamy viruses (FVs) enter host cells via endocytosis because all FV glycoproteins examined display pH-dependent fusion activities. Only the prototype FV (PFV) glycoprotein has also significant fusion activity at neutral pH, suggesting that its uptake mechanism may deviate from other FVs. To gain new insights into the uptake processes of FV in individual live host cells, we developed fluorescently labeled infectious FVs. Results: N-terminal tagging of the FV envelope leader peptide domain with a fluorescent protein resulted in efficient incorporation of the fluorescently labeled glycoprotein into secreted virions without interfering with their infectivity. Double-tagged viruses consisting of an eGFP-tagged PFV capsid (Gag-eGFP) and mCherry-tagged Env (Ch-Env) from either PFV or macaque simian FV (SFVmac) were observed during early stages of the infection pathway. PFV Env, but not SFVmac Env, containing particles induced strong syncytia formation on target cells. Both virus types showed trafficking of double-tagged virions towards the cell center. Upon fusion and subsequent capsid release into the cytosol, accumulation of naked capsid proteins was observed within four hours in the perinuclear region, presumably representing the centrosomes. Interestingly, virions harboring fusion-defective glycoproteins still promoted virus attachment and uptake, but failed to show syncytia formation and perinuclear capsid accumulation. Non-fused or non-fusogenic viruses are rapidly cleared from the cells by putative lysosomal degradation. Monitoring the fraction of viruses containing both Env and capsid signals as a function of time demonstrated that PFV virions fused within the first few minutes, whereas fusion of SFVmac virions was less pronounced and observed over the entire 90 minutes measured. Conclusions: The characterized double-labeled FVs described here provide new mechanistic insights into FV early entry steps, demonstrating that productive viral fusion occurs early after target cell attachment and uptake. The analysis highlights apparent differences in the uptake pathways of individual FV species. Furthermore, the infectious double-labeled FVs promise to provide important tools for future detailed analyses on individual FV fusion events in real time using advanced imaging techniques.

Background: It has not been investigated whether there are associations between urinary iodine (UI) excretion measurements some years apart, nor whether such an association remains after adjustment for nutritional habits. The aim of the present study was to investigate the relation between iodine-creatinine ratio (ICR) at two measuring points 5 years apart. Methods: Data from 2,659 individuals from the Study of Health in Pomerania were analyzed. Analysis of covariance and Poisson regressions were used to associate baseline with follow-up ICR. Results: Baseline ICR was associated with follow-up ICR. Particularly, baseline ICR >300 mu g/g was related to an ICR >300 mu g/g at follow-up (relative risk, RR: 2.20; p < 0.001). The association was stronger in males (RR: 2.64; p < 0.001) than in females (RR: 1.64; p = 0.007). In contrast, baseline ICR

Background: It has been argued that perceived functional incapacity might be a primary characteristic of chronic fatigue syndrome ( CFS) and could be explained by physical symptoms. If so, it could be expected to be closely associated with physical, but not psychological symptoms. The study tests this hypothesis. Sampling and Methods: The sample consisted of 73 patients, with a diagnosis of CFS according to the Oxford criteria, randomly selected from clinics in the Departments of Immunology and Psychiatry at St. Bartholomew's Hospital, London. The degree of fatigue experienced by patients was assessed using the Chalder Fatigue Questionnaire and a visual analogue scale. Self-rated instruments were used to measure physical and social functioning, quality of life, and physical and psychological symptoms. Results: Principal-component analysis of all scale scores revealed 2 distinct components, explaining 53% of the total variance. One component was characterized by psychological symptoms and generic quality of life indicators, whilst the other component was made up of physical symptoms, social and physical functioning and indicators of fatigue. Conclusions: The findings suggest that perceived functional incapacity is a primary characteristic of CFS, which is manifested and/or explained by physical symptoms. Copyright (C) 2008 S. Karger AG, Basel