Elimination by an organism of metabolic waste products
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2 episodes with Excretion
2 episodes with Excretion
2 episodes with Excretion
2 episodes with Excretion
3 episodes with Excretion
7 episodes with Excretion
2 episodes with Excretion
2 episodes with Excretion
2 episodes with Excretion
Book a class in June and July and get 50% off! EasyStoriesInEnglish.com/Classes An old fisherman sits by the sea, waiting for fish to come. He has seen the world change hugely through his life. But today, something different is waiting in the water: something monstrous. Go to EasyStoriesInEnglish.com/Return for the full transcript. Get episodes without adverts + bonus episodes at EasyStoriesInEnglish.com/Support. Your support is appreciated! Level: Intermediate. Genre: Philosophical. Vocabulary: Moustache, Frown, Broom, Fishing rod, Excretion, Barnacle, Wrath, Kelp, Froth. Setting: Modern. Word Count: 1220. Author: Ariel Goodbody. Learn more about your ad choices. Visit megaphone.fm/adchoices
Den här gången går vi igenom en något invecklad historia som tidigare aldrig beskrivits i detalj, men som innehåller ett exempel på storskalig amerikansk kopiering av östeuropeisk teknologi under kalla kriget, hallucinerande apor, ett mystiskt motgift och en koppling till Israel via CIA. Vi försöker nysta upp det hela steg för steg och förklara varför det är principiellt intressant samt ta upp en oväntad vinkel av särskild relevans för de med svår allergi än idag. Källorna inkluderar allt från CIA:s arkiv till gamla farmakologiska tidskrifter, en tidigare hemligstämplad tjeckoslovakisk forskningsartikel, och mycket annat (därför blir källförteckningen nedan ett urval snarare än uttömmande).Länk till den öppna föreläsningen på FHS den 7 maj:https://www.fhs.se/arkiv/kalenderhandelser/2025-02-12-hotbilder-fran-genetisk-teknologi.htmlKällor (ett urval):Washington Post-artikeln (1984):https://www.cia.gov/readingroom/docs/CIA-RDP90-00965R000100130039-8.pdf"Assessment of the Weapons and Tactics Used in the October 1973 Middle East War" (1974), Weapons Systems Evaluation Group:https://www.cia.gov/readingroom/docs/LOC-HAK-480-3-1-4.pdf"Chemical Warfare: Progress and Problems in Defensive Capability" (1986). US General Accounting Office, Washington D.C.Kreicer, M. (1967), Nekatorie sposobi rasceta dozirovok dlja celoveka ishodjascih na rezultatov polucennih na podopitnih zivotnih (Rus.). Sbornik Vedeckych Praci, 25, 27-71"Nervgasmotmedel: aktuellt kunskapsläge" (2005), FOI:https://www.foi.se/rest-api/report/FOI-R--1610--SEVojvodic, V. B. & M. Maksimovic (1972). "Absorption and Excretion of Pralidoxime in Man after Intramuscular Injection of PAM-2CL and Various Cholinolytics", European Journal of Clinical Pharmacology 5, 58-61Von Bredow, Jürgen D. et al. (1991). "Effectiveness of Oral Pyridostigmine Pretreatment and Cholinolytic-Oxime Therapy against Soman Intoxication in Nonhuman Primates", Fundamental and Applied Toxicology 17, 761-770
In this episode, we review the high-yield topic of Drug Excretion from the Pharmacology section. Follow Medbullets on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets
Dr. Sharon Stills delves into the intricate relationship between hormone imbalances and inflammation in this episode. Learn how hormones impact more than reproductive health, influencing systems from immunity to heart health. Explore the significant role of environmental toxins in our health, highlighting how exposure to everyday toxins can escalate inflammation and disrupt hormonal functions. Discover practical, natural strategies to manage and balance hormones. Dr. Stills offers actionable insights to enhance your body's healing potential and maintain overall wellness. In This Episode: 00:00 Introduction to Inflammation and Toxins 02:53 Introducing Dr. Sharon Stills 04:40 The Hormone and Inflammation Connection 07:29 The Role of Toxins in Inflammation 08:50 The Six Phases of Homotoxicology 10:33 The Importance of Excretion and Healthy Inflammation 17:26 Key Lab Markers for Inflammation 21:44 Tracking Biomarkers and Root Causes 23:17 Balancing the Nervous System: From Fight or Flight to Rest and Digest 25:07 Advanced Therapies for Nervous System Regulation 26:21 The Importance of an Anti-Inflammatory Lifestyle 29:00 Key Lab Tests and Biomarkers for Hormone Health 29:25 Understanding Hormone Imbalances in Men and Women 39:46 Nutrient Deficiencies and Their Impact on Health 42:37 Introducing Stills Health Center: A Family Clinic for Holistic Healing 45:04 Conclusion and Final Thoughts Fuel your body with Paleo Valley's grass-fed meat sticks, the ultimate healthy snack packed with protein and healthy fats to stabilize blood sugar and satisfy cravings. These meat sticks are made without sugar, additives, or preservatives and are perfect for on-the-go, guilt-free snacking. Choose from fresh options like original summer sausage, garlic, teriyaki, and jalapeno in grass-fed beef and pasture-raised turkey. With an optimal omega-6 to omega-3 ratio, these snacks help reduce inflammation and support immune health, energy, and radiant skin. Ready to try? Visit paleovalley.com/jockers for a 15% discount on Paleo Valley products today! This podcast is sponsored by ShopC60.com. C60 is a powerful, Nobel Prize-winning antioxidant that helps to optimize mitochondrial function, fights inflammation, and neutralizes toxic free radicals! I'm a big fan of using C60 in conjunction with your keto and intermittent fasting lifestyle to support your immune system, help your body detox, and increase energy and mental clarity. My favorite C60 products for Keto & IF lifestyles include C60 Purple Power in Organic MCT Coconut Oil (you can add this to your coffee) and their delicious Sugar-Free C60 Gummies (made with allulose and monk fruit)! If you are over the age of 40, and you'd like to kick fatigue and brain fog to the curb this year, visit shopc60.com and use the coupon code “JOCKERS” for 15% OFF and start taking back control over your health today! “We need to realize hormones impact so much more than just the things we tend to associate with hormones." – Dr. Sharon Stills Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio Resources: Visit https://shopc60.com/jockers – Use code “JOCKERS” to get 15% off! Paleovalley - visit paleovalley.com/jockers Connect with Dr. Sharon Stills: Website - https://drstills.com/ Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https://www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/ If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/
Les infrastructures se mettent en place et avec elles le rapprochement entre eau potable et assainissement s'opère. Des entreprises commencent à maitriser les deux domaines. S'ensuit donc une évolution des modes de gestion au cours du 20ème siècle. D'abord la concession, puis la régie publique et enfin l'affermage. Pourquoi ? Comment ? C'est ce que raconte ce dernier épisode.Intervenant.e.s : Christelle Pezon (chercheuse en politique de l'eau) et Marc Laimé (journaliste spécialiste de l'eau).Si l'épisode vous a plu, contribuez au financement participatif du podcast en cliquant ici.Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.
Le rejet des eaux usées en rivière n'est plus soutenable. Bon nombre de fleuves français sont alors pollués. Il convient donc de mettre en place des usines de traitement à la sortie du tout à l'égout. Différents systèmes sont alors développés mais un seul va finir par s'imposer : la boue activée. Celui-ci va devenir le modèle majoritaire et des stations d'épuration vont être construites un peu partout sur le territoire métropolitain.Intervenant.e.s : Bernard Barraqué (chercheur en gestion durable de l'eau), Michel Gousailles (ingénieur en assainissement) et Jacques Lesavre (ingénieur en assainissement)Si l'épisode vous a plu, contribuez au financement participatif du podcast en cliquant ici.Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.
Pendant la seconde moitié du 20ème siècle, le recyclage des matières tente d'être maintenue mais la crise de l'énergie et le développement de la société de consommation vont venir balayer ce modèle. A la suite du premier choc pétrolier, l'incinération va donc s'imposer comme la principale filière de traitement des déchets en France. L'industrie du déchet née.Intervenant.e.s : Etienne Dufour (historien de la matière organique) et Sabine Barles (historienne de l'assainissement et des déchets).Si l'épisode vous a plu, contribuez au financement participatif du podcast en cliquant ici.Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.
A partir de la découverte des énergies fossiles, la fertilisation des terres agricoles est envisagée de manière complètement différente. Tout d'abord, on ramasse le guano, puis on creuse pour récolter la potasse d'Alsace et les phosphates. Le dernier coup de massue va être donné durant la première guerre mondiale avec l'invention du procédé haber-bosh. Une innovation qui va nous permettre d'accéder au plus grand stock d'azote sur Terre, l'azote de l'air.Intervenant.e.s : Fabien Esculier (chercheur en assainissement) et Sabine Barles (historienne de l'assainissement).Si l'épisode vous a plu, contribuez au financement participatif du podcast en cliquant ici.Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.
We are diving into the intricate processes of liver detoxification, from the anatomy of the liver and its blood flow circuitry to the phases of detoxification involving enzymes and conjugation reactions. I highlight the importance of supporting optimal liver function to prevent toxin accumulation and associated symptoms, underscoring the significance of various compounds and peptides, such as Dihydromyricetin (DHM), N-acetylcysteine (NAC), and peptide bioregulators like Svetinorm and Ovagen, in aiding liver health and detoxification processes. Topics: 1. Introduction to Liver Detoxification - Importance of supporting the liver in processing and eliminating toxins - Symptoms of liver congestion: digestive issues, bloating, dark under eye circles, edema, skin conditions, etc. 2. Liver Biology and Processes - Anatomy of the liver: lobes, lobules, ducts - Blood flow circuitry within the liver - Hepatic Artery - Portal Vein - Sinusoids - Hepatic Vein - Exchange of molecules between sinusoids and hepatocytes 3. Phases of Liver Detoxification - Phase 1 metabolism: Cytochrome P450 enzymes - Phase 2 metabolism: Conjugation reactions - Glucuronidation - Sulfation - Glutathione conjugation - Amino acid conjugation - Acetylation reactions - Methylation reactions 4. Elimination of Toxins - Movement of conjugates back into bloodstream - Excretion into bile ducts - Role of bile in digestion and excretion 5. Implications of Impaired Detoxification - Accumulation of toxins leading to various symptoms - Hormonal imbalance and its effects 6. Introduction to Supporting Compounds and Peptides - Overview of newer compounds and peptides for liver support - Dihydromyricetin (DHM) - N-acetylcysteine (NAC) - Calcium D-glucarate - Globe artichoke - Milk thistle - Selenium - Glycine - Taurine 7. Peptide Bioregulators for Liver Support - Svetinorm - Ovagen - Molecular composition and interaction with DNA - More trials and research are welcomed in this field Thank you to our episode sponsors: Check out MoonBrew Here! Check out The Honest Tooth Here! Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support
Le développement de l'eau potable dans les cours d'immeubles et les maisons va venir bousculer les modes de vie des urbains. L'invention de la toilette à chasse d'eau et son utilisation va liquéfier les matières, ce qui va complexifier leur transformation en engrais agricoles. En ville, les rues s'imperméabilisent. Il faut donc mettre en place un réseau de canalisations pour évacuer toutes ces eaux et les renvoyer à la rivière.Intervenant.e.s : Sabine Barles (historienne de l'assainissement) et Michel Gousailles (ingénieur en assainissement).Si l'épisode vous a plu, contribuez au financement participatif du podcast en cliquant ici.Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.
Parallèlement au recyclage des matières, l'eau va être introduite de manière durable dans les villes. Les écrits des lumières et les découvertes scientifiques du 19ème vont radicalement faire évoluer la notion d'hygiène. C'est dans ce contexte qu'une grande bassine va être placée dans de nombreux foyers pour inciter la population à se laver. C'est l'époque des épidémies de choléra en Europe, des débuts de la médecine et de la compréhension des mécanismes de contaminations.Intervenant.e.s : Monique Eleb (historienne de l'architecture), Sabine Barles (historienne de l'assainissement) et Renaud Piarroux (épidémiologiste).Si l'épisode vous a plu, contribuez au financement participatif du podcast en cliquant ici.Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.
Avec la révolution industrielle, le recyclage des excréments humains va être optimisé jusqu'à prendre une place centrale dans l'équilibre du système alimentaire français au cours du 19ème siècle. Un siècle que l'on nommera « l'âge d'or du recyclage » puisque de nombreux brevets vont être déposés pour transformer nos excréments en engrais.Intervenante : Sabine Barles, historienne de l'assainissement.Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.
Unit 1 Kinetics and Dynamics 1_6 Excretion This is a free open educational resource I am reading as an audio to make more accessible under Creative Commons Attribution 4.0 International License. While I am a licensed pharmacist, I am not providing any health advice, this is for educational purposes only. Here's my website: https://www.memorizingpharm.com/ Where you can get the Memorizing Pharmacology: A Relaxed Approach audiobook, possibly for free: https://www.audible.com/pd/Memorizing-Pharmacology-Audiobook/B09JVBHRXK?source_code=AUDFPWS0223189MWT-BK-ACX0-281667&ref=acx_bty_BK_ACX0_281667_rh_us OER Pharmacology Book Link to download or view the book presented in the video. https://wtcs.pressbooks.pub/pharmacology/ Want to get in touch with me, tonythepharmacist@gmail.com
Welcome to our bonus series - Out Of The Clutter! These short episodes are here to help you conquer that random/annoying/boring task you've been putting off. Is it a pile of clothes you need to hang? Toys to sort and put away? Papers to file? Whatever it is, WE ARE HERE to get your mind out of the clutter as you cruise into the weekend. We want our PodcATTS community to do this together each week. If you take a before/after pic or hyperlapse video, post it and tag us! (@allthattosay_podcast on IG) We will share it to the our Clutter community to keep the motivation going. Take this time for YOU and your sanity!! Learn more about the All That To Say Podcast by visiting www.podcatts.com. Want even more from Miranda and Kristin? Subscribe to our Patreon for just $6/month. Enjoy bonus episodes and exclusive ATTS content you won't find anywhere else! CALL US on the Honesty Hotline (HoHo!) anytime! 877-914-6464. We want to hear from you. Leave an anonymous message to be featured on an upcoming episode! Maybe you need to get something off your chest or need our honest opinion on something? We want to hear it! Follow us on Instagram at @allthattosay_podcast. We love meeting new people, so leave a comment or better yet...share the love with your friends! You can also find our weekly podcast videos on our YouTube channel! If you love our content, be sure to like, subscribe, download, rate, and review! We hope to continue bringing this unhinged FIRE CONTENT every week. xoxo.
Elle Scott is a former AWS executive and Iridologist. Elle's website: https://www.showmeyourset.com/ ***TIMESTAMPS*** 0:00 - Elle's time in Ecuador 6:16 - Paul Rosolie; Why Amazon is key to life 10:02 - Replacing trees in the Amazon jungle 15:01 - The Ancient Amazon Shuar Tribe in Ecuador 20:49 - Young Shuar leaving the tribe & its civilization 26:20 - Eating with the Shuar 31:27 - The Tribe who shrinks human heads 38:53 - Preserving the Shuar and ecotourism in the Amazon 44:32 - Alien Civilization in the Amazon & Palo Santo Trees 51:39 - The Amazon's Goldminers 55:28 - How Elle got into tech industry; Replacing her girlfriend 1:02:32 - Elle's random one year hiatus as a flight attendant 1:03:59 - Elle's time at AWS in Hawaii working with DOD 1:08:20 - The Culture in Tech Industry 1:12:26 - How messy was Gov - Tech world? 1:16:17 - Why Elle doesn't own Amazon Alexa 1:23:28 - Jeff Bezos & Power 1:33:12 - Companies can simulate everything ahead of time 1:38:45 - What is Iridology? 1:45:22 - The Skin is the 3rd kidney 1:48:20 - The Acid Scale & Mucus in the body 1:56:23 - Expectant Mothers' lymphatic systems effect on children 2:02:54 - How Relationships with food determine result 2:07:21 - How Elle fixed a powerlifter; Amino Acids 2:13:05 - Excretion & your health; Animal hormones in food 2:20:41 - The food pyramid is a disaster 2:29:04 - Elle's view on her work ~ Get $150 Off The Eight Sleep Pod Pro Mattress / Mattress Cover (USING CODE: “JULIANDOREY”): https://eight-sleep.ioym.net/trendifier Julian's Instagram: https://www.instagram.com/julianddorey ~ Music via Artlist.io
Drs Michael S. Saag and Charles W. Flexner discuss the mechanisms of drug-drug interactions and the promise and limitations of longer-acting HIV therapeutics for both treatment and prevention. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/986504). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources HIV Infection and AIDS https://emedicine.medscape.com/article/211316-overview Drug Interactions With Antiretroviral Therapy (ART) https://emedicine.medscape.com/article/2039809-overview Common Drug Interactions With Protease Inhibitors https://emedicine.medscape.com/article/2041624-overview HIV-Protease Inhibitors https://pubmed.ncbi.nlm.nih.gov/9562584/ The Role of Drug Metabolizing Enzymes in Clearance https://pubmed.ncbi.nlm.nih.gov/24392841/ AIDS Clinical Trials Group https://actgnetwork.org/ Ritonavir https://reference.medscape.com/drug/norvir-ritonavir-342627 The Cytochrome P450 Isoenzyme and Some New Opportunities for the Prediction of Negative Drug Interaction In Vivo https://pubmed.ncbi.nlm.nih.gov/29780235/ Boosting https://clinicalinfo.hiv.gov/en/glossary/boosting Cytochrome p450 Structure, Function and Clinical Significance: A Review https://pubmed.ncbi.nlm.nih.gov/28124606/ Darunavir https://reference.medscape.com/drug/prezista-darunavir-342647 Atazanavir https://reference.medscape.com/drug/reyataz-atazanavir-342608 Tenofovir Disoproxil Fumarate https://clinicalinfo.hiv.gov/en/drugs/tenofovir-disoproxil-fumarate/patient The Structure and Mechanism of Drug Transporters https://pubmed.ncbi.nlm.nih.gov/34272696/ Tenofovir Alafenamide (TAF) Clinical Pharmacology https://pubmed.ncbi.nlm.nih.gov/35146360/ Prodrugs for Improved Drug Delivery: Lessons Learned From Recently Developed and Marketed Products https://pubmed.ncbi.nlm.nih.gov/33137942/ Update on Drug-Drug Interaction at Organic Cation Transporters: Mechanisms, Clinical Impact, and Proposal for Advanced In Vitro Testing https://pubmed.ncbi.nlm.nih.gov/33896325/ The Role of Organic Anion Transporting Polypeptides in Drug Absorption, Distribution, Excretion and Drug-Drug Interactions https://pubmed.ncbi.nlm.nih.gov/27783531/ Creatinine Clearance https://pubmed.ncbi.nlm.nih.gov/31334948/ Dolutegravir https://reference.medscape.com/drug/tivicay-tivicay-pd-dolutegravir-999861 Cobicistat https://reference.medscape.com/drug/tybost-cobicistat-999845 Paxlovid https://pubmed.ncbi.nlm.nih.gov/35138785/ Interaction Between Ritonavir and Statins https://pubmed.ncbi.nlm.nih.gov/11959074/ COVID-19 Drug Interactions https://www.covid19-druginteractions.org/checker Cabotegravir https://reference.medscape.com/drug/vocabria-apretude-cabotegravir-1000364 Lenacapavir https://reference.medscape.com/drug/sunlenca-lenacapavir-4000240 Inhibitors of the HIV-1 Capsid, a Target of Opportunity https://pubmed.ncbi.nlm.nih.gov/29782334/ Flip-Flop Pharmacokinetics--Delivering a Reversal of Disposition: Challenges and Opportunities During Drug Development https://pubmed.ncbi.nlm.nih.gov/21837267/ Polymeric Biomaterials for Medical Implants and Devices https://pubmed.ncbi.nlm.nih.gov/33465850/ Microneedle Arrays Combined With Nanomedicine Approaches for Transdermal Delivery of Therapeutics https://pubmed.ncbi.nlm.nih.gov/33419118/ Preexposure HIV Prophylaxis https://emedicine.medscape.com/article/2054869-overview
We interface with our environment via the air we breathe, the food and water we eat and drink, and through physical contact via our skin.This lecture explores how these biological barriers act to protect us against toxins and toxicants, through an exploration of dose, detoxification and elimination mechanisms, antioxidant defences and innate immune mechanisms.A lecture by Dr Ian Mudway recorded on 27 March 2023 at Barnard's Inn Hall, London.The transcript and downloadable versions of the lecture are available from the Gresham College website: https://www.gresham.ac.uk/watch-now/interfaces-worldGresham College has offered free public lectures for over 400 years, thanks to the generosity of our supporters. There are currently over 2,500 lectures free to access. We believe that everyone should have the opportunity to learn from some of the greatest minds. To support Gresham's mission, please consider making a donation: https://gresham.ac.uk/support/Website: https://gresham.ac.ukTwitter: https://twitter.com/greshamcollegeFacebook: https://facebook.com/greshamcollegeInstagram: https://instagram.com/greshamcollegeSupport the show
“Foot-Long Blood Clots” From mRNA, Says Pathologist Dr. Ryan Cole w/ Dr Kelly Victory – Ask Dr. Drew (start @ 20:30 – 40:30) Putin just scored a KNOCKOUT blow to Europe and the WEF | Redacted with Clayton Morris (0:00 – 9:05) Watch Out Us Dollar! China and Saudi are Building a New Currency and World (0:00 – 9:40) Watercress Found to Block Breast Cancer Cell Growth Natural Society November 27, 2022 A new study from the University of Southampton indicates that watercress could be useful in the fight against breast cancer. According to the study, published in the British Journal of Nutrition, a compound in the cruciferous plant could work to turn off signals in the cells that are used to facilitate cancer growth, thereby starving cancer cells to death. When a tumor outgrows its own blood supply, it sends signals to surrounding tissues to deliver more oxygen and nutrients. Its these signals that phenylethyl isothiocyanate—the watercress compound—may actually shut off. For the research, a small group of breast cancer survivors ate a bowl of watercress and then had their blood tested for a period of 24 hours following. The participants had a significant level of phenylethyl isothiocyanate in their blood following the meal and the signaling function was “measurably affected.” According to the study's abstract: “Although further investigations with larger numbers of participants are required to confirm these findings, this pilot study suggests that flow cytometry may be a suitable approach to measure changes in 4E-BP1 phosphorylation following the ingestion of watercress, and that dietary intake of watercress may be sufficient to modulate this potential anti-cancer pathway.” The research is promising, and when paired with research on the benefits of other cruciferous vegetables, we may have identified the family of vegetables that can successfully combat cancer (NEXT) Going to the gym in later life could lower dementia risk Australian National University, November 30, 2022 Early results from a new study led by ANU indicate that people aged in their 60s and early 70s could lower their risk of dementia if they maintained a healthy weight by going to the gym to retain muscle mass. Lead researcher Dr Marnie Shaw said “As our population ages, the number of people with dementia will increase, but an active lifestyle offers real opportunities for reducing dementia risk,” said Dr Shaw from the ANU Research School of Engineering. The researchers observed about 400 people aged in their 60s and early 70s from Canberra at several different stages over time. Dr Shaw said the study was the first to show that the relationship between body mass index (BMI) and brain shrinkage changed from midlife to older age. Research evidence has linked brain shrinkage to the onset of dementia. “Both increasing and decreasing BMI was associated with more brain shrinkage at an older age,” Dr Shaw said.”Preliminary results from our research indicate that it's important for people in later years to go to the gym to maintain a healthy weight and not lose their muscles,” Dr Shaw said (NEXT) Not all micronutrients are created equal: Study identifies some supplements that benefit cardiovascular health Brown University, December 5, 2022 Healthy diets are rich in antioxidants like amino acids, omega-3 fatty acids and vitamin C, but exactly how beneficial these micronutrients are for cardiovascular health has long been controversial. Now a new meta-analysis published in the Journal of the American College of Cardiology provides some clarity. Researchers systematically reviewed a total of 884 studies available to date on micronutrients taken as dietary supplements and analyzed their data. They identified several micronutrients that do reduce cardiovascular risk—as well as others that offer no benefit or even have a negative effect. More than 883,000 patients were involved in the combined studies. “For the first time, we developed a comprehensive, evidence-based integrative map to characterize and quantify micronutrient supplements' potential effects on cardiometabolic outcomes,” said Simin Liu, MD, professor of epidemiology and medicine at Brown University and a principal investigator for the study. “Our study highlights the importance of micronutrient diversity and the balance of health benefits and risks.” “Research on micronutrient supplementation has mainly focused on the health effects of a single or a few vitamins and minerals,” Liu said. “We decided to take a comprehensive and systematic approach to evaluate all the publicly available and accessible studies reporting all micronutrients, including phytochemicals and antioxidant supplements and their effects on cardiovascular risk factors as well as multiple cardiovascular diseases.” The researchers looked at randomized, controlled intervention trials evaluating 27 different types of antioxidant supplements. They found strong evidence that several offered cardiovascular benefit. These included omega-3 fatty acid, which decreased mortality from cardiovascular disease; folic acid, which lowered stroke risk; and coenzyme Q10, an antioxidant sometimes marketed as CoQ10, which decreased all-cause mortality. Omega-6 fatty acid, L-arginine, L-citrulline, Vitamin D, magnesium, zinc, alpha-lipoic acid, melatonin, catechin, curcumin, flavanol, genistein and quercetin also showed evidence of reducing cardiovascular risk. Not all supplements were beneficial. Vitamin C, Vitamin D, Vitamin E and selenium showed no effect on long-term cardiovascular disease outcomes or type-2 diabetes risk, while beta carotene supplements increased all-cause mortality. According to the researchers, the findings point to the need for more personalized, precision-based dietary interventions that involve specific combinations of beneficial supplements. Further study is needed, including large, high-quality interventional trials to investigate the long-term effects of certain micronutrients on health. (NEXT) Scientists find inorganic food additives might make babies more vulnerable to allergies Université Paris-Saclay (France), December 5, 2022 Nanotechnologies have revolutionized food technology with changes to food production, manufacture, and processing that are intended to make our food safer and healthier. Phytosanitary products, processing aids, food additives, and surfaces that touch food in storage can all transfer nanoparticles that might be consumed by humans. In a review published in Frontiers in Allergy, Mohammad Issa, at the Université Paris-Saclay, and colleagues pointed out that such a significant change to food production could have unforeseen health consequences. The team presented evidence that suggested that nanoparticles not only cross the placenta to reach developing fetuses but leave them at greater risk of potentially life-threatening food allergies. “Due to the immunotoxic and biocidal properties of nanoparticles, exposure may disrupt the host-intestinal microbiota's beneficial exchanges and may interfere with intestinal barrier and gut-associated immune system development in fetus and neonate,” said Dr. Karine Adel-Patient, corresponding author of the study. “This may be linked to the epidemic of immune-related disorders in children, such as food allergies—a major public health concern.” We know that environmental factors play a significant role in allergy development, and the higher prevalence in children suggests that early life environmental factors are likely key. Dietary practices and the environment affect gut health in young children, and the deprivation of gut microbiota and a wide range of dietary proteins can affect the development of oral tolerance. To understand how nanoparticles can disrupt this delicate balance, the team focused on three nanoparticle-bearing additives which are regularly found in food. “Such agents can cross the placental barrier and then reach the developing fetus,” explained Adel-Patient. “Excretion in milk is also suggested, continuing to expose the neonate.” While nanoparticles crossing the placenta has been demonstrated in rodents, there is also evidence that the additives cross the placenta in humans as well. Nanoparticles are not absorbed in the gut but accumulate there, and affect the bacteria present in the gut microbiome by changing the number of species present and their proportions. Given the evidence for the importance of the gut microbiome in developing a well-educated immune system, this is concerning for allergy development. Nanoparticles also affect the epithelium intestinal barrier, which is another essential component of a healthy reaction to dietary proteins. “Our review highlights the urgent need for researchers to assess the risk related to exposure to foodborne inorganic nanoparticles during a critical window of susceptibility and its impact on children health.” (NEXT) Pregnant moms' stress may accelerate cell aging of white, not Black, kids University of California, San Francisco, December 4, 2022 Does stress during pregnancy impact children's cell aging, and does race matter? The answer is yes, according to a new UC San Francisco study published in Psychological Medicine. UCSF researchers followed 110 white and 112 Black women from age 10 to about 40 as well as their first child (average age 8) to understand stress influences on the women's health and its effects on their children. What they found surprised them. Financial stress during pregnancy, such as job loss and the inability to pay bills, was linked to accelerated cellular aging of white children but not Black children. “Ours is the first study we know of that examined effects of stressor type and timing on this aspect of health for white and Black mothers and their children,” said lead study author Stefanie Mayer, Ph.D., UCSF assistant professor of psychiatry at the Weill Institute for Neurosciences. “We can speculate on the reasons for the results, but the truth is we need to do more research to understand them.” Cellular age can be measured by the length of one's telomeres, the protective DNA caps at the end of chromosomes. Telomere length naturally shortens with age, and shorter telomeres predict earlier onset of illnesses such as heart disease and diabetes as well as earlier death.Previous studies showed that prenatal stressors are linked to shorter offspring telomeres, but those studies comprised mostly white mothers. The UCSF study recruited an equal number of white and Black mothers, and examined how stressors that occurred during their adolescence (pre-pregnancy), pregnancy and throughout their lifespan affected their children's telomeres. The telomere effect in white children was seen only for stressors during pregnancy—not adolescence or across the lifespan. Non-financial stressors, such as divorce or death of a loved one, had no observable telomere effect on children of either race. (NEXT) Association Between Consumption of Ultraprocessed Foods and Cognitive Decline University of São Paulo Medical School (Brazil), December 5, 2022 Although consumption of ultraprocessed food has been linked to higher risk of cardiovascular disease, metabolic syndrome, and obesity, little is known about the association of consumption of ultraprocessed foods with cognitive decline. This was a multicenter, prospective cohort study with 3 waves, approximately 4 years apart, from 2008 to 2017. Data were analyzed from December 2021 to May 2022. Participants were public servants aged 35 to 74 years old recruited in 6 Brazilian cities. Main Outcomes and Measures Changes in cognitive performance over time evaluated by the immediate and delayed word recall, word recognition, phonemic and semantic verbal fluency tests, and Trail-Making Test B version.Results A total of 10, 775 participants data were analyzed. The mean (SD) age at the baseline was 51.6 years. During follow-up of 8 (6-10) years, individuals with ultraprocessed food consumption above the first quartile showed a 28% faster rate of global cognitive decline and a 25% faster rate of executive function decline compared with those in the first quartile. A higher percentage of daily energy consumption of ultraprocessed foods was associated with cognitive decline among adults from an ethnically diverse sample. These findings support current public health recommendations on limiting ultraprocessed food consumption because of their potential harm to cognitive function.
How to Relieve Seasonal Allergies Naturally Did you know 50 million Americans suffer from allergies? With spring being in full swing, we're here to help give you action steps for how to relieve seasonal allergies naturally. Dr. Ryan explains there are 5 signs of life known in chiropractic which are: Assimilation - the process of eating and turning food into living cells. Excretion - the process of getting rid of toxicity so you can keep the body cleansed. Adaptation - the ability for your body to deal with something and overcome it. Growth - the ability for living things to grow. Reproduction - the process of cells reproducing. This is extremely relevant to allergies because they occur as a result of your body not being able to adapt to its environment. For example, Dr. Ryan and Ashley went on a trip to Oklahoma where they came into contact with a new environment (ie: pollen) which was very different from the pollen in their home state of Ohio. As a result, their immune system response was weak and they were unable to adapt, causing allergy symptoms such as a runny nose, or watery eyes. In order to give the body what it needs to overcome allergies, we have to go back to the 5 signs of life. To get to the adaptation stage, you have to finish assimilation and excretion first, which means you have to be intentional about what you're putting in your body (ie: healthy food) to ensure it can be supported in the best way possible for assimilation. It's also important to minimize toxicity through excretion so nothing stands in the way of proper functioning. The last and most important key to adaptation is to take care of your spine and nervous system. By getting your spine checked regularly, we can remove interference in the body and help it function at its full potential. Learn more about how to relieve seasonal allergies naturally by listening to today's new episode! Available now on Apple Podcasts, Spotify & more! *Disclaimer: MaxLiving chiropractors don't treat allergies or any disease process. We look for root cause(s) of dysfunction and empower the patient with resources and action steps to help restore optimal function to the body. We do this through our 5 Essentials approach including chiropractic, functional nutrition, detoxification, movement, and mindset. The contents of The MaxLiving Podcast and website are strictly for educational purposes and are not intended to be a replacement for professional medical advice, diagnosis, or treatment. Never ignore professional medical advice because of something you heard or read on The MaxLiving Podcast or website. If you have a medical emergency, call your doctor or 911 immediately. Chiropractic Resources To find a doctor near you, visit maxliving.com/locations. For additional holistic health content, follow us on Instagram @maxlivingofficial and Facebook @maxliving.
Kyle and Evan get out and reconnect with nature, rank their favorite beers, discuss personal finance, and do a little guided meditation! No King of Queens Episode Review Segment this time, sorry. CREDITS & LINKS Show Theme: “Lazy & Bluesy” by Astrofreq The OFFICIAL “The Charlie and Bob Show” Twitter: @charliebobshow --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app
The Gallaudet 11 were a group of Deaf men who were subjects in NASA's research into the human body in the early years of the space program. The transcript for this episode is here: https://bit.ly/3KnAGhA Research: Bergey, Jean Lindquist. “Deaf Perspective: Inside View of Early Space Research.” Quest: The History of Spaceflight Quarterly. Vol. 25. No. 1. 2018. Bergey, Jean Lindquist. “How Being Deaf Made the Difference in Space Research.” Smithsonian Air and Space Museum. 4/7/2017. https://airandspace.si.edu/stories/editorial/how-being-deaf-made-difference-space-research Calandrelli, Emily. “In the 1960's 11 deaf men helped NASA get to the moon.” Twitter thread. 12/12/2019. https://twitter.com/thespacegal/status/1205258285412020225?lang=en Williams, Damien P., Heavenly Bodies: Why It Matters That Cyborgs Have Always Been About Disability, Mental Health, and Marginalization (June 8, 2019). Available at SSRN: https://ssrn.com/abstract=3401342 or http://dx.doi.org/10.2139/ssrn.3401342 Clark, Brant and Ashton Graybiel. “Human Performance During Adaptation to Stress in the Pensacola Slow Rotation Room.” Aerospace Medicine. Vol. 32, No. 2, February 1961. Colehour, James K. and Ashton Graybiel. “Excretion of 17-Hydroxycorticosteroids, Catechol Amines, and Uropepsin in the Urine of Normal Persons and Deaf Subjects with Bilateral Vestibular Defects Following Acrobatic Flight Stress.” United States Naval School of Aviation Medicine and National Aeronautics and Space Administration. May 10, 1963. Crowell, Rachel. “Disabled Astronauts Blaze New Space Trails.” Scientific American. 10/20/2021. https://www.scientificamerican.com/article/disabled-astronauts-blaze-new-space-trails/ David, Leonard. “Equal access to space: New study investigates how to get more 'parastronauts' aloft.” Space.com. 12/31/2021. https://www.space.com/inclusive-human-spaceflight-parastronaut-study Dowd, Jim. “9 Deaf Men Volunteer for Navy Research.” Pensacola News Journal. 12/28/1962. Eveleth, Rose. “It's Time to Rethink Who's Best Suited for Space Travel.” Wired. 1/27/2019. https://www.wired.com/story/its-time-to-rethink-whos-best-suited-for-space-travel/ Fregly, Alfred and Robert S. Kennedy. “Comparative Effects of Prolonged Rotation at 10 RPM on Postural Equilibrium in Vestibular Normal and Vestibular Defective Human Subjects.” Bureau of Medicine and Surgery. March 23, 1965. Gallaudet University. “Deaf Difference + Space Survival Exhibition Video.” https://www.gallaudet.edu/museum/ddss-doc/ Gohd, Chelsea. “Disability ambassadors successfully complete Zero-G flight.” Space.com. 10/19/2021. https://www.space.com/astroaccess-disability-ambassadors-zero-g-flight Harrington, Tracy. “Three Deaf Men Serve as Human Guinea Pigs.” Pensacola News Journal. 7/11/1962. Hotovy, Hannah. “How 11 Deaf Men Helped Shape NASA's Human Spaceflight Program.” NASA. 5/4/2017. https://www.nasa.gov/feature/how-11-deaf-men-helped-shape-nasas-human-spaceflight-program Irwin, J.A. et al. “The Pathology of Sea-sickness.” The Lancet. 11/26/1881. James, William. “The Sense of Dizziness in Deaf-mutes.” American Annals of the Deaf and Dumb , APRIL, 1883, Vol. 28, No. 2. Via JSTOR. https://www.jstor.org/stable/44460811 Kellogg, Robert S. et al. “Motion Sickness Symptomatology of Labyrinthine Defective and Normal Subjects During Zero Gravity Maneuvers.” Technical Documentary Report AMRL-TDR-64-47. Air Force Systems Command. June 1964. Kennedy, Robert S. et al. “Symptomology Under Storm Conditions in the North Atlantic in Control Subjects and Persons with Bilateral Labyrinthine Defects.” United States Naval School of Aviation Medicine and National Aeronautics and Space Administration. May 1965. Larimer, Sarah. “‘I wanted to serve': These deaf men helped NASA understand motion sickness in space.” Washington Post. 5/5/2017. https://www.washingtonpost.com/news/retropolis/wp/2017/05/05/i-wanted-to-serve-these-deaf-men-helped-nasa-understand-motion-sickness-in-space/ NASA Video. “How Deaf and Hearing Impaired People Helped the Space Program.” Via YouTube. 5/11/2013. https://www.youtube.com/watch?v=zM47-nz24i4 Space Center Houston. “Gallaudet 11 – Deaf Right Stuff.” 2/18/2020. https://www.facebook.com/watch/?v=3102869376605071 U.S. Naval School of Aviation Medicine Pensacola, Fla. “Symposium on the Role of Vestibular Organs in the Exploration of Space.” Ashton Graybiel, General Chairman. Jan. 20-22 , 1965. See omnystudio.com/listener for privacy information.
Sauna questions answered with expert Dr. Rhonda Patrick: Infrared vs traditional saunas? Can sauna bathing lower the risk of dementia, heart disease, stroke, depression, and all-cause mortality? How exactly should we use saunas for optimal benefit (duration, frequency, temperature, etc.)? Dr. Rhonda Patrick is a cell biologist with a Ph.D. in biomedical science from the University of Tennessee Health Science Center and St. Jude Children's Research Hospital. Dr. Patrick is the Co-Founder of FoundMyFitness.com. View Dr. Rhonda Patrick's recent review article on saunas in Experimental Gerontology here: https://www.sciencedirect.com/science/article/pii/S0531556521002916 Subscribe to Dr. Patrick's YouTube channel here: https://www.youtube.com/user/FoundMyFitness?sub_confirmation=1 Interviewer: Kyle Allred, Physician Assistant, Producer, and Co-Founder of MedCram.com Topics covered: 00:00:00 - Intro to Saunas and Rhonda Patrick 00:01:04 - Summary of sauna health benefits (lowers dementia, cardiovascular, depression risk, etc.) 00:07:09 - A review article vs primary research and Dr. Jari Laukkanen 00:07:58 - More on cardiovascular benefits of sauna 00:10:48 - Does sauna use lower hypertension risk? 00:11:56 - Sauna use may improve fitness and endurance 00:14:48 - Can sauna use lower Alzheimers and dementia risk? 00:16:43 - What are heat shock proteins? 00:19:18 - Dr. Patrick's research on amyloid-beta 42 / heat shock proteins 00:20:30 - How Rhonda Patrick became interested in Saunas 00:22:20 - Endorphins, opiate receptors, depression, and sauna use 00:26:36 - Sauna associated with lower inflammatory markers 00:27:14 - Interleukin 6 (IL-6) and sauna use 00:29:20 - Brain-derived neurotrophic factor (BDNF) and neuroplasticity 00:32:01 - More cellular repair mechanisms (NRF2) and hormesis 00:34:00 - Eustress and intermittent fasting 00:37:38 - Sauna and muscle atrophy 00:39:54 - Excretion of heavy metals and toxins through sweat 00:41:58 - Heart rate variability and sauna use 00:43:30 - Sauna mimics moderate-intensity exercise 00:47:32 - What Rhonda Patrick does in the sauna 00:49:22 - Countries / cultures utilizing hyperthermia 00:51:34 - Infrared sauna benefits vs. traditional Finnish sauna (and waon therapy) 00:55:39 - Details about Rhonda Patrick's sauna routine (temp., duration, dry vs. humid etc.) 01:01:43 - Utilizing sauna to extend a workout 01:02:33 - Can a long hot shower or bath mimic sauna benefits? 01:03:27 - Hydration before and after sauna bathing 01:04:36 - Cold exposure after sauna use? 01:06:24 - How to tell if in the sauna for too long? 01:08:10 - Contraindications/people who shouldn't use sauna 01:12:28 - Continuous glucose monitors and sauna 01:14:25 - Limitations of current sauna research 01:18:06 - More on Finland and saunas 01:18:50 - More on heat shock proteins 01:19:46 - Closing thoughts FOLLOW DR. RHONDA PATRICK YouTube: https://www.youtube.com/user/FoundMyFitness?sub_confirmation=1 Twitter: https://twitter.com/foundmyfitness Podcast: https://open.spotify.com/show/5QjpaU0o1Q2MkVZwwG3y7d MEDCRAM + MEDICAL PROGRAMS AND HOSPITALS: MedCram offers group discounts for students and medical programs, hospitals, and other institutions. Contact us at customers@medcram.com if you are interested. MEDIA CONTACT: Media Contact: customers@medcram.com Interview Produced and Edited by Kyle Allred with Daphne Sprinkle FOLLOW US ON SOCIAL MEDIA: https://www.facebook.com/MedCram https://twitter.com/MedCramVideos https://www.instagram.com/medcram DISCLAIMER: MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor. #Sauna #optimalheatlh #hottub
Ein "Radioclash" ist eine 60-minütige Mischung aus Teilen von 12 oder 15 Minuten zu einem Thema. Gemacht oder Ausgesucht durch Sie oder jemanden Anderen. ## ThisIsRadioclash #011 : Excrétion et Sécrétion 1. This is radioclash - Introduction Jingle ### MELODIK PINPON 1. Melodik Pinpon - Tu me mouille 2. Futurama - Saison 5 épisode 1 3. Melodik Pinpon - Le parfum de ces dames 4. ??? - Projet de pub Prins 5. Le docteur g - L'urinoir 6. Hell Boy - Fart step 7. ??? - Projet Pub Petterman (fr) 8. Le docteur g - Le guichetier 9. Melodik Pinpon - colle de contact 10. Futurama - Saison 5 épisode 1 11. Le docteur g - Haleine de chiottes 12. Anal Phazer - Chilliy winds 13. ??? - Projet pub Petterman (nl) 14. Futurama - Saison 5 épisode 1 15. Melodik Pinpon - le vent liberateur 16. Melodik Pinpon - le caca ### BERNARD GRANCHER 1. Wolf eyes - black vomit / MF Doom - Vomit / Fille qui mousse - Esplanade 2. Venetian Snares Speedranch-Making Orange Things - Halfway Up the Stairway of Mucus 3. Cacacyclope - cacattention ! 4. Banjo et la batterie - pelle à merde 5. SF - Ma vitamine c'est la cyprine 6. Toxic Lipstick - I Smoke My Vomit 7. Christophe tarkos - L'homme de merde 8. Evil Moisture - blood sauce ### GLAFOUK 1. Léo Ferré - La solitude 2. AS Dragon avec Michel Houellebecq - Paris Dourdan 3. ??? - [Extrait de "C'est arrivé près de chez vous" (Découpé à la tronçonneuse) 4. Adult - Nausea 5. Serge Gainsbourg - Premiers Symptômes 6. Klootzak Vs. Kotszak - Zum Kotzen (Amputé au couteau) 7. ??? - [Publicité Reni Deflatine] ### OGOUN FERRAILLE 1. Josie Duflan et les ponettes sauvages - Mon sperme dans les étoiles 2. Kania Tieffer - This is a caca 3. J.j. lionel - Moi je dois faire pipi 4. Gogol 1er - Je pisse 5. Felix Kubin - Menstruation glamour 6. Kuruki - Crocodile tears Une émission présidée par Bernard Grancher. # This is Radioclash Dieses Projekt wurde im "Musiques Incongrues Forum" nach einer Idee von Ogon Feraille geboren. Es ist alles Partizipative und Interaktiv, jeder ist herzlich willkommen. Machen Sie mit oder schlagen Sie ein Thema vor. Was immer Sie wollen, wann immer Sie wollen! Sind Sie ein Profi oder nicht, Mädchen oder nicht, Roboter oder nicht, geil oder nicht! * http://www.musiques-incongrues.net/ * http://www.thisisradioclash.org/
Did you know there are smart toilets? Yes, that's right. Smart toilets. Research professor Sonia Grego is currently working on a toilet that works as a health-screening tool, using sensors and artificial intelligence to analyse waste.
Did you know there are smart toilets? Yes, that's right. Smart toilets. Research professor Sonia Grego is currently working on a toilet that works as a health-screening tool, using sensors and artificial intelligence to analyse waste.
More about the international Pandora Papers investigation and the latest on redrawing district maps in Miami-Dade County. Plus, research on ... fish pee.
Teagasc is running a weekly Let's Talk Dairy webinar series which is also being made available as a bonus podcast episode. In this webinar, Stuart Childs, Teagasc Dairy Specialist, discusses the proposed nitrate excretion bands for dairy cows and the implications that they may have for farmers To register for future Let's Talk Dairy webinars go to: https://www.teagasc.ie/corporate-events/lets-talk-dairy/ For more episodes from the Dairy Edge podcast go to the show page at: https://www.teagasc.ie/animals/dairy/the-dairy-edge-podcast/
Having fun isn't hard when you have an ereader and online access to your local library's collection of ebooks. Join Jack, Mark, and Mikhail for an extended discussion of keyboard shortcuts, books, and MacBooks with a healthy sprinkling of smooth segues between topics. Like, really smooth. Like, smoother than a rock eroded by wind, rain, […]
In this episode, we review the high-yield topic of Drug Excretion from the Pharmacology section. Follow Medbullets on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets --- Send in a voice message: https://anchor.fm/medbulletsstep1/message
What's the craziest way to kill your husband, if you want to ensure you wind up on Dateline? Also, how many strokes does it take to finally stroke out?This episode's topics include a porch gator in Florida and a very smelly murder plot. Also, because of how much they love it, Quentin and Cassie play another game of "Real or Fake?" but this time with medication side effects! Is it really true that a certain medication causes you to lose your fingerprints, or that your nipples may turn darker? Tune in to find out!Also, this week's 100% REAL sponsor is the Call Center Simulator VR Game!If you enjoy our content and would like to hear more, please rate us on Podchaser and Apple Podcasts, and be sure to subscribe to our show!Also, please follow us on social media and share our episodes with your friends! We can only provide extra content and other offers after growing our audience!Facebook - @strictlylaidbackInstagram - @strictlylaidbackTwitter - @backstrictlyWebsite - https://strictly-laid-back.captivate.fmLast but not least, huge shout-out to Cody James for producing all the music you hear on our podcast. He can be reached for inquiries @ csjamesmusic@gmail.com.
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Welcome to Scatterbrain Podcast Episode 72! Thanks to everyone who has supported us by listening, subscribing, rating, and sharing with friends and family. This week, we review “Excretion of Mortality”, the latest release from Seattle's Cerebral Rot. Then we learn about physicist Freeman Dyson, his involvement in "Project Orion", and discuss the idea of theoretical mega-structures called "Dyson Spheres". Scatterbrain Podcast with Ian and Dan: Subscribe, Listen and Share! Twitter - @ScatterbrainPod / Instagram - @ScatterbrainPodSD --- Send in a voice message: https://anchor.fm/scatterbrain-podcast/message
In this episode, Dr Matt & Dr Mike discuss pharmacokinetics (how your body alters a drug) and explore the 4 stages; Absorption, Distribution, Metabolism, Excretion.
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.In today's episode, I will answer your question , the one centred around topic of the day-"How drugs are eliminated?"Then I will tell you the difference in terms Excretion and Elimination. I will then start off the talk with discussions about Presystemic metabolism or First pass metabolism. After deriving an equation about Hepatic Extraction Ratio, I will officially start my talks about topic of the day i.e. Introduction to Kinetics of drug elimination. I will be listing various major and minor routes of drug elimination, then I will be initially give full description of Biliary excretion.In this I will be laying special emphasis upon "Enterohepatic Cycling". Definition, essence, examples, features, mechanism, exceptions , all will be conveyed and explained nicely! I will be concluding today's talks with two phrases or words of wisdom, science and mathematics to solve day to day dilemmas ! To wrap up, until next time(A' la prochaine!)..... For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. In today's episode, I will answer your question , the one centred around topic of the day-"How drugs are eliminated?"Then I will tell you the difference in terms Excretion and Elimination. I will then start off the talk with discussions about Presystemic metabolism or First pass metabolism. After deriving an equation about Hepatic Extraction Ratio, I will officially start my talks about topic of the day i.e. Introduction to Kinetics of drug elimination. I will be listing various major and minor routes of drug elimination, then I will be initially give full description of Biliary excretion.In this I will be laying special emphasis upon "Enterohepatic Cycling". Definition, essence, examples, features, mechanism, exceptions , all will be conveyed and explained nicely! I will be concluding today's talks with two phrases or words of wisdom, science and mathematics to solve day to day dilemmas ! To wrap up, until next time(A' la prochaine!)..... For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!! You can access various links via https://linktr.ee/ispharmacologydifficult
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.In today's episode, I will answer your question , the one centred around topic of the day-"How drugs are eliminated?"Then I will tell you the difference in terms Excretion and Elimination. I will then start off the talk with discussions about Presystemic metabolism or First pass metabolism. After deriving an equation about Hepatic Extraction Ratio, I will officially start my talks about topic of the day i.e. Introduction to Kinetics of drug elimination. I will be listing various major and minor routes of drug elimination, then I will be initially give full description of Biliary excretion.In this I will be laying special emphasis upon "Enterohepatic Cycling". Definition, essence, examples, features, mechanism, exceptions , all will be conveyed and explained nicely! I will be concluding today's talks with two phrases or words of wisdom, science and mathematics to solve day to day dilemmas ! To wrap up, until next time(A' la prochaine!)..... For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult
Sacred Clay detox protocol+ Complete Guide will be outlined in upcoming episodes today GB asks why good bile flow is so important? You will learn about powerful herbs and foods that support your liver and gallbladder. GB shares nfo about supplements for liver and gallbladder health. IGB will be talking and will be explaining how practicing the Biliary Sludge Protocol to support your liver and gallbladder will ensure a good bile flow. Importance of Good Bile Flow Bile is greenish brown liquid or digestive juice that emulsifies fats for your small intestine to absorb. It is made up of cholesterol, salts, and bilirubin. It is important that the bile helps the digestion of fat to allow different processes in your body. Bile also contains waste products to be released through bowel movements. When something interferes with good bile flow, a variety of problems may occur. Poor bile flow may lead to a variety of digestive issues, including poor nutrient absorption, overgrowth of bad gut bacteria, gut inflammation, and leaky gut syndrome. Leaky gut syndrome happens when due to damage of your gut lining, undigested food particles and toxins are able to cross into your bloodstream through holes on your intestinal barrier. Leaky gut syndrome may result in digestive problems and autoimmune conditions, such as lupus, Hashimoto’s disease, and rheumatoid arthritis (1). To understand better the importance of good bile flow, let’s take a look at the 4 major functions of the bile. Fatty Acid Metabolism In their unaltered form, fat has little use in your body. Fats must be emulsified and broken down to be absorbed and used for energy. Poor fat emulsification can lead to digestive issues, such as chronic diarrhea and irritable bowel syndrome (IBS). This why bile is incredibly important to emulsify them, so emulsified fats can transport fat-soluble nutrients, such as vitamins A, D, E, and K around your body to protect your immune system and overall health. Kill Off Bad Microbes The bacterial makeup of your microbiome is incredibly important for your overall health. Too much bad bacteria and gut flora imbalance may increase your risk of inflammation, heart disease, diabetes, neurological conditions, cancer, mental health issues, and other health problems. Bile helps to regulate and balance your microbiome by killing off dangerous pathogens, such as bad bacteria Excretion of Waste Products Along with urine, sweat, and breath, one of the main ways your body gets rid of waste and toxins is through bowel movements. While water-soluble toxins mainly get released through urine, fat-soluble toxins leave your body through your bowels. If your body cannot release waste regularly through the bowels, it can lead to bacterial overgrowth, inflammation, weight gain, digestive troubles, and consequent health problems. bhsales.vpweb.com --- Send in a voice message: https://anchor.fm/bhsales/message
bengreenfieldfitness.com/primepodcast Dr. Anthony Beck, who first appeared on my show in the podcast entitled "The Danger Of ‘Shrooms, Eating & Supplementing “Seasonally”, Whether Lectins Are Really Bad For You & Much More With Dr. Anthony G. Beck!", is an author, speaker, and leader in the medical world with over 20 years experience in the areas of Functional Medicine, Chinese Medicine, Clinical Nutrition, Orthomolecular Medicine, Hormone Replacement Therapy, Sports Medicine, and Exercise Physiology. He maintains four national medical board certifications, is the Medical Director for Task Force Dagger Foundation (which provides benevolent health care for U.S. military special forces operators and their families), is the founder and chief medical officer for Balance Protocol Institute, is the founder and CEO of Helion Nutraceuticals, and is also the CEO of Hydration Solutions Inc. As a physician who has practiced Functional Medicine for over 20 years, Dr. Anthony G. Beck doesn’t merely manage diseases—he helps people resolve them. With extensive education in many clinical disciplines such as Functional Medicine, clinical nutrition, systems biology, epigenetics, and nutrigenomics, he takes a dynamic approach to assessing, educating, and working with his patients to achieve their highest levels of well-being. Even more importantly, Dr. Beck looks to educate and empower patients to demand a higher level of care from their health care providers. Dr. Beck’s methods involve an array of aspects including a healthful lifestyle design, individualized nutrition, hormone balancing, resolving immune dysfunction and hidden infectious diseases, extensive laboratory and functional testing, detoxification, and preventative medicine. In this podcast, we discuss Dr. Beck's unique Balance Prime approach to health and medicine, include his top tips for optimizing your air, light, water, sound, EMF, food and much more! During our discussion, you'll discover: -Cancel culture hits home...07:30 -Anthony's old-school learning process vs. Dr. Google...11:35 -About the Balance Protocol Method...15:05 -Biotransformation 101...18:55 -How the body is "one giant excretion machine"...26:50 -The oil which lubes the machine that is Dr. Anthony Beck...35:05 -Anthony's water filtration set up...44:45 - Why you may want to avoid wearing some of the more popular wearables on the market...50:35 - How Anthony uses sound to tune and tone his body...54:10 - Why Anthony isn't completely sold on the concept of BioGeometry...1:00:00 - Mineral and electrolyte imbalances addressed...1:04:40 - Anthony's Balance Protocol Program break down...1:08:00 -And much more! Do you have questions, thoughts or feedback for Dr. Anthony Beck or me? Leave your comments at bengreenfieldfitness.com/primepodcast and one of us will reply!
Sufficient vitamin D during gestation and early life can lower susceptibility to allergy in infants Wageningen University (Netherlands), April 5, 2021 According to news originating from Wageningen, Netherlands, the research stated, “Worldwide, the prevalence of allergies in young children, but also vitamin D deficiency during pregnancy and in newborns is rising. Vitamin D modulates the development and activity of the immune system and a low vitamin D status during pregnancy and in early life might be associated with an increased risk to develop an allergy during early childhood.” Our news editors obtained a quote from the research from Wageningen University and Research: “This review studies the effects of vitamin D during gestation and early life, on allergy susceptibility in infants. The bioactive form of vitamin D, 1,25(OH)2D, inhibits maturation and results in immature dendritic cells that cause a decreased differentiation of naive T cells into effector T cells. Nevertheless, the development of regulatory T cells and the production of interleukin-10 was increased. Consequently, a more tolerogenic immune response developed against antigens. Secondly, binding of 1,25(OH)2D to epithelial cells induces the expression of tight junction proteins resulting in enhanced epithelial barrier function. Thirdly, 1,25(OH)2D increased the expression of anti-microbial peptides by epithelial cells that also promoted the defense mechanism against pathogens, by preventing an invasive penetration of pathogens.” According to the news editors, the research concluded: “Immune intervention by vitamin D supplementation can mitigate the disease burden from asthma and allergy. In conclusion, our review indicates that a sufficient vitamin D status during gestation and early life can lower the susceptibility to develop an allergy in infants although there remains a need for more causal evidence.” Training in compassion improves the well-being of relatives to people with mental illness Aarhus University (Denmark), April 7, 2021 If relatives of people with mental illness become better at accepting the difficult emotions and life events they experience - which is what training in compassion is about - their anxiety, depression and stress is reduced. These are the results of a new study from the Danish Center for Mindfulness at Aarhus University. Being a relative of a person with a mental illness can be very burdensome. It can feel like a great responsibility, and many people struggle with feelings of fear, guilt, shame and anger. A new study from the Danish Center for Mindfulness shows that eight weeks of training in compassion can significantly improve the well-being of relatives. Compassion is a human quality that is anchored in the recognition of and desire to relieve suffering. In other words, compassion occurs when we come into contact with our own or others' suffering and feel motivated to relieve our own or others pain. "After completing the course, the relatives had increased their well-being on several parameters. They could deal with the illness in a new and more skillful way, and we saw that the training reduced their symptoms of depression, anxiety and stress," says psychologist and PhD student Nanja Holland Hansen, who is behind the study. And the positive results were maintained after a six month follow-up. Trying to fix what is difficult "The relatives learned that the more they turn towards what is difficult, the more skillful they may act. For example, relatives often try to 'fix' the problem or the challenge - so as to relieve their loved ones of what is difficult. That's a huge pressure to constantly deal with, and very few people can bear it," says Nanja Holland Hansen. Living with chronic fear She goes on to explain that training in compassion helps people to find the strength and courage to bear pain and suffering when life is difficult. It may seem both sensible and intuitive to guard yourself from the confrontation or avoid what is difficult and unpleasant. But this is the paradox of the training, explains the researcher. Because it is precisely actions and thoughts like these that shut down our compassion and thereby maintain the suffering. "Fear and grief are emotions that take up a lot space for relatives of people with mental illness. For example chronic fear, which is a real fear that parents of a child with schizophrenia have about whether their child is going to commit suicide, or whether a child with autism will ever enjoy a 'normal life'," explains Nanja Holland Hansen and continues: "Our suffering is maintained inside of us when we don't work with it. To avoid feeling pain, we may resort to behaviour such as working too much or buying things that we don't need. It's therefore in all these everyday actions that our compassion training becomes important and can be used to help alleviate what is difficult," she says. No one escapes The purpose of training in compassion is thus more than just feeling empathy or worrying about another person. "Not a single person can completely avoid experiencing painful things in their life. In this way we're all the same. But what isn't the same for everyone is our ability to deal with the pain and suffering we experience. Training programmes in compassion have been developed because the research shows that we can train and strengthen our mental health. With systematic training of compassion, we generate more attention - and understanding of - our own thoughts, feelings and behaviour. And this helps us to develop the tools and skills to engage in healthier relations with ourselves and others," she explains. A total of 161 relatives of people with mental illness participated in the study. This makes the study one of the largest of its kind in the world, and also the first scientific randomised clinical trial carried out with relatives in Denmark. The relatives were between 18 and 75 of age and were family members to people with various psychiatric disorders such as e.g. ADHD, schizophrenia and depression. Meditation as homework The relatives met once a week in groups of twenty participants over an eight-week period. Each session lasted two hours and was structured with small group exercises, large group discussions, instruction in the theme of the week and meditation. The homework consisted of twenty minutes of daily meditation. "There is definitely a shortage of offers for these relatives. They're often told that they should remember to take care of themselves, but they haven't learned how to. We found that those who were involved in the study received the tools for precisely this," says Nanja Holland Hansen. The results have just been published in the scientific journal JAMA. "My hope is that local authorities and regions can offer this type of intervention for relatives. It should be an option and could easily be incorporated into our healthcare system. Economically and socially, a healthy person going on sick leave solely because he or she is a relative is a huge loss," says the researcher. [Billedtekst:]: "Up to fifty percent of relatives of people with mental illness risk becoming ill themselves. That's why it's important that we also keep them and their well-being in mind," says Nanja Holland Hansen. Sesaminol prevents Parkinson's disease by activating the Nrf2-ARE signaling pathway Osaka City University (Japan), March 331, 2021 Parkinson's disease (PD) is a neurodegenerative disease caused by the degeneration of substantia nigra neurons due to oxidative stress. Sesaminol has strong antioxidant and anti-cancer effects. We investigated the preventive effect on PD as a new physiological action of sesaminol produced from sesaminol glycoside using in vitro and in vivo PD models. To prepare an in vitro PD model, 6-hydroxydopamine (6-OHDA) was added to human neuroblastoma (SH-SY5Y cells). The viability of SH-SY5Y cells decreased dose-dependently following 6-OHDA treatment, but the addition of sesaminol restored viability to the control level. 6-OHDA increased intracellular reactive oxygen species production, and the addition of sesaminol significantly suppressed this increase. No Nrf2 expression in the nucleus was observed in the control group, but a slight increase was observed in the 6-OHDA group. The sesaminol group showed strong expression of Nrf2 in the cytoplasm and nucleus. NAD(P)H: quinone oxidoreductase (NQO1) activity was enhanced in the 6-OHDA group and further enhanced in the sesaminol group. Furthermore, the neurotoxine rotenone was orally administrated to mice to prepare an in vivo PD model. The motor function of rotenone-treated mice was shorter than that of the control group, but a small amount of sesaminol restored it to the control level. The intestinal motility in the rotenone group was significantly lower than that in the control group, but it remained at the control level in the sesaminol group. The expression of α-synuclein in the substantia nigra increased in the rotenone group but decreased in the sesaminol group. The rotenone group exhibited shortening and damage to the colonic mucosa, but these abnormalities of the colonic mucosa were scarcely observed in the sesaminol group. These results suggest that sesaminol has a preventative effect on PD. Study finds connection between lifestyle choices, Alzheimer disease Brigham Young University, April 8, 2021 A recent study out of BYU has linked lifestyle choice to Alzheimer's disease, at least to some degree, through findings that show a possible energy gap between the amount of glucose and ketones being used to power the brain. BYU professor Ben Bikman, who studies diabetes and insulin resistance, thought of a fundamental question surrounding Alzheimer's disease and insulin resistance in the brain. Bikman said there has been growing evidence that the brains in humans with Alzheimer's disease are deficient in the use of glucose. "The brain has a certain energy demand, let's say that is 100%," Bikman said. "In most instances, glucose is providing virtually all of that energy, nearly 100% all of the time. There is a secondary fuel known as ketones, so the average brain is consuming almost all of its energy from glucose with a little bit of energy coming from ketones at any moment. In some individuals, the brain starts to become deficient in its ability to use glucose. So now glucose can only provide about 60% of that energy, and then ketones would be expected to fill up the rest of that energy. The tragedy is that the average individual has almost undetectable levels of ketones and that's entirely a matter of lifestyle." This lack of ketones as well as the brain's resistance to insulin is linked to lifestyle. Insulin is expected to stimulate tissues or cells to take in the glucose and use it for energy. As the brain becomes more insulin resistant, it can't take in glucose anymore and this is something Bikman said has been shown in other research. The BYU research expanded on some of those findings. "We found that indeed the expression of genes involved in glucose metabolism was significantly down, very broad across every cell type we looked at in the brain," Bikman said. "All of the cell types we looked at had significant reductions in glucose-related genes, but the ketone-related genes were almost totally normal." This is key because it shows that if the brain can receive more ketones, there is a possibility that one could overcome that energy gap. While it may not be able to be filled in with glucose, it can be with ketones but ketones need to be produced by one's body. With many people having diets that are high in refined sugars and starches, insulin is elevated all of the time, and ketones are only produced when insulin levels are low. These conditions include fasting or low-carb diets, also known as keto diets. Ph.D. student Erin Saito is another one of the lead authors of the study and is doing this project as her dissertation. Another collaborator included Washington University of Saint Louis, which gave the BYU research team access to various brain banks. "BYU is a wonderfully collaborative environment, not only encouraging collaborations within the university but also outside of the university," Bikman said. "Thus communicating with our internal and external collaborators was very easy and very natural. There was very much a common interest to work on this project together, a common enthusiasm for answering a question that had not been asked yet. It would not have been possible without that mutual collaboration and enthusiasm." He added that managing the project with enthusiastic students was a delight, making it easy because of the enthusiasm surrounding the project. Bikman said it is gratifying for him to be able to contribute to what little is known about Alzheimer's disease, because traditional strategies and approaches have continued to fail. "Looking at Alzheimer's disease as a metabolic problem, I would say, is the greatest breakthrough in our understanding of the disease in decades," Bikman said. Looking at it through the metabolic side of things allows people to possibly detect the problem years in advance, looking at changes in brain glucose metabolism long before Alzheimer's sets in. Bikman believes that someday the metabolic approach to Alzheimer's will be the standard of care. Moving forward, Bikman said he hopes that people feel empowered when it comes to Alzheimer's disease. He wants people to not look at it as a passive process where they are the victim, but rather acknowledging that their lifestyle choices can either act as the culprit or the cure. "For too long we have viewed Alzheimer's disease as a disease that is no respecter of person, no respecter of choices and that is simply not true," Bikman said. "We have long known that people with metabolic disorders, like type 2 diabetes and insulin resistance, are at significantly greater risk of developing Alzheimer's disease and we have more evidence suggesting that dietary choices and changes do make significant improvements in someone's cognition." Even someone in the midst of Alzheimer's disease can see improvements in memory and learning with a lifestyle change, according to Bikman, and he added that he hopes this evidence will help to strengthen that view and empower individuals to take matters into their own hands. New Study Shows Broad Benefits Of High-CBD Cannabis Health Canada Research Institute, April 6, 2021 With CBD exploding in popularity, new studies continue to reveal its potential benefits. A new study published in the journal Aging-US reported that high-CBD cannabis has anti-inflammatory and anti-cancer properties and may even help reduce COVID symptoms. Cannabidiol, or CBD, is a non-psychoactive compound in cannabis and is legal in all 50 states. “Cannabis sativa, especially those high in the anti-inflammatory cannabinoid cannabidiol, has been found to alter gene expression and inflammation and harbour anti-cancer and anti-inflammatory properties,” the researchers at Health Canada concluded. As such, they say specific CBD extracts “may become a useful and safe addition to the prevention/treatment of COVID-19 as an adjunct therapy.” Researchers hypothesized that high-CBD C. sativa extracts may be used to down-regulate ACE2 expression in target COVID-19 tissues. Using artificial 3D human models of oral, airway and intestinal tissues, they identified 13 high-CBD C. sativa extracts that decrease ACE2 protein levels. Some C. sativa extracts down-regulate serine protease TMPRSS2, another critical protein required for SARS-CoV-2 entry into host cells. This is not the first study to suggest that CBD could combat respiratory illnesses like COVID. In April 2020, researchers at the University of Nebraska and the Texas Biomedical Research Institute published a peer-reviewed article suggesting that CBD could be included in the treatment regimen for the COVID-19 coronavirus as THC and CBD both appeared to reduce the severe lung inflammation associated with the virus. In July 2020, researchers at the Dental College of Georgia and Medical College of Georgia found early evidence that Cannabidiol, or CBD, may help reduce the cytokine storm and excessive lung inflammation that killed many patients with COVID-19. “Our laboratory studies indicate pure CBD can help the lungs recover from the overwhelming inflammation, or cytokine storm, caused by the COVID-19 virus, and restore healthier oxygen levels in the body,” says co-author Dr. Jack Yu, physician-scientist and chief of pediatric plastic surgery at MCG. In October 2020, the same research group published a follow-up peer-reviewed study identifying the mechanism they believe was responsible for the encouraging results of using CBD to reduce lung inflammation. “One way CBD appears to reduce the “cytokine storm” that damages the lungs and kills many patients with COVID-19 is by enabling an increase in levels of a natural peptide called apelin, which is known to reduce inflammation and whose levels are dramatically reduced in the face of this storm,” they concluded. While this is incredibly encouraging news for relief from COVID, businesses that sell CBD edibles and oils are not allowed to mention these benefits in advertising because the FDA has not officially approved it for any specific treatment. Apparently, experimental vaccines are okay to advertise but natural plant extracts aren’t. The new study above is just another to suggest cannabis and CBD can help fight cancer. There have been many studies as well as countless confirmed anecdotal accounts. In 2018, a 44-year-old UK mom refused chemo for her aggressive triple-negative breast cancer. She opted for CBD oil instead and was declared cancer-free five months later. In 2019, an 81-year-old diagnosed with lung cancer shrunk his tumors in half by taking CBD oil. The case study was published in the peer-reviewed journal Sage. More recently, a Colorado State University study showed that CBD extract can slow growth and kill cancer cells in aggressive brain cancer. “Our experiments showed that CBD slows cancer cell growth and is toxic to both canine and human glioblastoma cell lines,” said Chase Gross, a doctoral student participating in the study. “Importantly, the differences in anti-cancer affects between CBD isolate and extract appear to be negligible.” That’s not all, CBD has shown potential for treating a variety of other ailments such as arthritis, seizures, chronic pain, high blood pressure, Alzheimer’s and more – with little to no severe side effects that are common with leading pharmaceuticals. Big Pharma hopes more people don’t discover natural treatments to common health issues, like CBD, because it could severely impact their profits and influence. Polyphenol pills counter inflammation in women on hormonal contraceptives: RCT Universidade Federal do Rio Grande do Sul (Brazil), April 7, 2021 Supplements containing a mixture of polyphenols may counter increases in pro-inflammatory markers in women of childbearing age using combined hormonal contraceptives, says a new study. The supplements, formulated with resveratrol, catechin, quercetin, chlorogenic acid and cyanidin, were also found to prevent the increases in markers of systemic oxidative stress like F2-isoprostane, according to findings published in Prostaglandins, Leukotrienes and Essential Fatty Acids . “The increase in biomarkers of inflammation and oxidative stress observed in the present study were possibly caused by the use of hormonal contraceptives, as verified in the [control group], and this change was not observed in the group that used polyphenols,” wrote researchers from the Institute of Cardiology and the Universidade Federal do Rio Grande do Sul in Brazil. “Therefore, the results of this polyphenol supplementation showed that the antioxidant and anti-inflammatory effects observed in the studied population is due to the reduction in plasma levels of PGE2, supporting the conceptual hypothesis, by its action on the inflammatory cascade, probably by COX inhibition.” Study details The Brazil-based researchers recruited 40 women aged between 25 and 35 using contraceptives, and randomly assigned them to receive either placebo or polyphenols (3,000 mg per day) for 15 days. “A higher dosage was chosen in order to reduce the risk of food ingestion of control group to overcome the dosage of polyphenol supplementation in the [polyphenol group],” they explained. Data from the 28 women who completed the study indicated that, as expected, markers of inflammation (PGE2 and C-reactive protein) and oxidative stress (F2-isoprostane) increased significantly in women in the placebo group. However, no such increases were observed in the polyphenol group. “Among participants of the polyphenols group, an inverse correlation was observed between the consumption of polyphenols estimated by the [food frequency questionnaire] with PGE2 levels at the end of the study. This finding had not yet been previously described in the literature and reinforces the hypothesis of the present study regarding the action of polyphenols in reducing PGE2 levels,” wrote the researchers. “The liver is the main organ involved in the metabolism of polyphenols, and metabolites are secreted in bile and urine. Excretion of polyphenols in participants of the [polyphenol group] was significantly higher than in the [control group], confirming the effective ingestion of capsules and absorption of compounds, which can vary depending on the amount ingested, the chemical structure of the substance and the intestinal flora of the subjects.” Childhood diet and exercise creates healthier, less anxious adults University of California Riverside, April 9, 2021 Exercise and a healthy diet in childhood leads to adults with bigger brains and lower levels of anxiety, according to new UC Riverside research in mice. Though diet and exercise are consistently recommended as ways to promote health, this study is the first to examine the long-lasting, combined effects of both factors when they are experienced early in life. "Any time you go to the doctor with concerns about your weight, almost without fail, they recommend you exercise and eat less," said study lead and UCR physiology doctoral student Marcell Cadney. "That's why it's surprising most studies only look at diet or exercise separately. In this study, we wanted to include both." The researchers determined that early-life exercise generally reduced anxious behaviors in adults. It also led to an increase in adult muscle and brain mass. When fed "Western" style diets high in fat and sugar, the mice not only became fatter, but also grew into adults that preferred unhealthy foods. These findings have recently been published in the journal Physiology and Behavior. To obtain them, the researchers divided the young mice into four groups -- those with access to exercise, those without access, those fed a standard, healthy diet and those who ate a Western diet. Mice started on their diets immediately after weaning, and continued on them for three weeks, until they reached sexual maturity. After an additional eight weeks of "washout," during which all mice were housed without wheels and on the healthy diet, the researchers did behavioral analysis, measured aerobic capacity, and levels of several different hormones. One of those they measured, leptin, is produced by fat cells. It helps control body weight by increasing energy expenditure and signaling that less food is required. Early-life exercise increased adult leptin levels as well as fat mass in adult mice, regardless of the diet they ate. Previously, the research team found that eating too much fat and sugar as a child can alter the microbiome for life, even if they later eat healthier. Going forward, the team plans to investigate whether fat or sugar is more responsible for the negative effects they measured in Western-diet-fed mice. Together, both studies offer critical opportunities for health interventions in childhood habits. "Our findings may be relevant for understanding the potential effects of activity reductions and dietary changes associated with obesity," said UCR evolutionary physiologist Theodore Garland. In other words, getting a jump start on health in the early years of life is extremely important, and interventions may be even more critical in the wake of the pandemic. "During the COVID-19 lockdowns, particularly in the early months, kids got very little exercise. For many without access to a park or a backyard, school was their only source of physical activity," Cadney said. "It is important we find solutions for these kids, possibly including extra attention as they grow into adults." Given that exercise was also shown to reduce adult anxiety, Cadney believes children who face these challenges may face unique physical and mental health issues as they become adults in the coming decade.
Project Metacosm: Extorting Public 'Tribunals' For S.E.L.E.N.E Excretion.
Full show notes @ https://thesternmethod.com/mark-simon/ Mark Simon, CN, CHCC, CPBN Mark Simon established the Nutritional Oncology Research Institute (NORI) in 2011 as an organization focused on advancing cancer care through optimization of diet and application of targeted nutraceuticals. Mark Simon's background and interests are in diverse fields including clinical nutrition, biomedical engineering, plant-based nutrition, naturopathic medicine and neuroscience. ***Resources Mentioned*** Nutritional Oncology Research Institute Cancer Schmancer Can Dietary Methionine Restriction Increase the Effectiveness of Chemotherapy in Treatment of Advanced Cancer? NORI PROTOCOL - methionine video by Dr. Mark Gregor Fruit, The Lymphatic System & Cancer: Dr. Robert Morse Book: Fit for Life by Harvey Diamond Scientific papers on Methionine, Sodium Selenite, Vit E, Melatonin AntibioticWatchdog Nutritional Oncology Research Institute - Cbd, Hemp CBD, Hemp NORI CBD - Cbd, Cbd, Alternative Health Products, Cbd Oil Nutritional Oncology Research Institute - Home Pure Organic Super-Greens Powder Algae Omega-3 Oil, 400 mg DHA per ml https://norinutraceuticals.com/shop/ols/products/selenium Zinc Chelate, 15 mg, 90 tablets Vitamin D3, 2,000 IU, 360 tablets Iodine, 1.8 mg/drop Sublingual Vitamin B12, 500 micrograms Methylcobalamin, 120 Tablets 1 oz. Organic Broccoli and Radish Sprout Powder (High Sulforaphane Content) Vitamin E Delta, Gamma Tocotrienols, Annatto Derived (DeltaGold), 60 ml, 21,000 mg Melatonin, 50 mg, 360 Tablets Glucosamine HCl Powder, 8 oz., 227 grams Sodium Selenite, 2 mg, 180 Slow Release Tablets *Use code STERN at checkout to receive a discount The Stern Method Website - What We Use: Top Anti-Cancer Supplements Essential Oils We Use Including Our Targeted Blends Cancer Fighting Tools for Detox and Cancer Fighting My Kid Cures Cancer Anti-Cancer, Non-Toxic, Healthy Lifestyle Products We Use *** In This Episode: Our guest today, Mark Simon, talks about how eating a low methionine diet can lead to better health and cancer cell death (apoptosis). In this episode, Mark and Ryan discuss the benefits of a plant-based diet which is high in fruits and berries, moderate in vegetables and void of animal products. Through his work at the Nutritional Oncology Research Institute, Mark has developed the NORI protocol, based on the two core concepts of restricting methionine intake and using high doses of sodium selenite (selenium salts) and other targeted nutraceuticals to reduce tumor cell growth. In-vivo studies and clinical experience affirm the effectiveness of this type of diet. The concept of using pro-oxidants versus anti-oxidants is discussed as is the mechanism of sodium selenite and the relationship between methionine and cancer. This conversation may challenge the way you currently view your nutritional protocol. We encourage you to keep an open mind. Be prepared to stretch your current point of view and perhaps gain some new insight and ideas. Please enjoy this next installment of the Anti-cancer Revolution! Be sure to let us know what you think below. 0:41 Fruit or no fruit – That is the million dollar question Mark promotes a methionine restricted diet - high fruit, moderate vegetables, no animal products Utilizes Vitamin E, tocotrienol, selenium, iodine 2:30 Overview of the NORI protocol Based on two core ideas - methionine restricted diet & high dose selenium (sodium selenite) Mark started the diet based on personal experience after his wife was diagnosed with stage 3 breast cancer Diet plays a huge role as a tool in cancer prevention Sodium selenite is a form of selenium studied for over 40 years Is a selective chemo-therapeutic agent Can kill cancer cells without causing harm to other cells High bio-availability Can be administered intravenously or orally 6:00 Relationship between methionine and cancer cells Mark discover the work of Dr. Daniel E. Epner, MD - clinical studies using methionine restricted diet Video by Dr. Mark Gregor on Mark’s website describing methionine and what it does Methionine is an amino acid If methionine is restricted, cancer cells die Could potentially work as stand-alone therapy 8:30 How do you reduce methionine in the body and what is the end goal? Through the diet methionine levels can be brought quite low All whole foods contain some level of methionine Fruits contain the least amount of methionine Grains, nuts, beans, seeds, animal products contain the most Best to cycle methionine levels on and off In the future hope is to be able to bring methionine levels to zero 10:05 What do cancer cells do with methionine? Cancer cells use methionine as a building block Methionine is not needed for normal cell growth- not an essential amino acid MTOR pathway is stimulated less with methionine restriction Methionine restriction makes cancer cells more sensitive to treatment NORI diet is a platform to slow down tumor growth and make cancer more sensitive to treatment 13:50 What are your thoughts on eating fruit? Fruit is not the same thing as table sugar Most fruits are low glycemic Fruitarian diet does not cause high blood sugar 80-10-10 diet (80% fruit, 10% protein, 10% fat) Sugar does not encourage tumor growth, insulin does Ketogenic diet doesn’t work long term because glutamine is not cut out of diet 18:00 NORI diet restricts other cancer-dependent amino acids besides methionine Glutamine Phenylalanine Isoleucine Tryptophan Asparagine 18:30 NORI diet is an alkaline diet Alkaline diet helps neutralize acidity around tumors Anti-inflammatory Anti-angiogenesis Dr. Robert Morse recommends a similar program 20:05 Where do you stand on juicing fruit? Is there a difference between eating fruit and vegetables with or without fiber? A little bit of freshly squeezed citrus juice is fine Bottled juices - no Believes juicing is counter-productive More antioxidants flooding the system makes it harder to fight cancer Hasn’t seen data showing success with juicing and stage 4 cancer Plant based diet is a good idea Cancers are crazier today than years ago Gerson’s original diet involved orange juice and lower protein (lower methionine) Juicing probably doesn’t get phytochemicals up to appropriate levels 23:45 Can you elaborate on antioxidants and cancer? Study with animals on low-antioxidant diet slowed tumor progression Normal cells operate on a low level of oxidative stress Cancer cells operate at a high level of oxidative stress because of altered metabolism Adding oxidative stress will push cancer cells over the edge Cancer cells are dependent on anti-oxidant systems like: Glutathione Thioredoxin Catalyse Superoxide dismutase If you block glutathione synthesis, cancer cells die off Putting anti-oxidants into the system aids cancer survival such as: Vitamin E (alpha-tocopherol form) Vitamin C NAC (N-Acetyl Cysteine) Vitamin A NORI program is careful not to incorporate juicing or other antioxidant supplements NORI program utilizes pro-oxidants which increase oxidative stress Sodium selenite Generates hydrogen peroxide Generates ROS (reactive oxygen species) Triggers cell apoptosis 28:30 What are your thoughts on using antioxidants to increase chemotherapy and drug success? Oncologists tell patients no antioxidant supplements because they know they will interfere with treatment Antioxidants protect cancer cells Mark hasn’t seen any research showing antioxidants make chemo work better Research shows pro-oxidant therapy helps chemo work better Sodium selenite Ozone therapy Sulforaphane (need 10-20 grams or more) - not too efficient 32:30 Can you give us a breakdown of the different levels of methionine within food groups? Foods highest in methionine: Chicken and fish Next: other animal products- beef, dairy, eggs Mark has been vegan for 30 years (supplements with B12 occasionally) Caution: B-12 can be used by cancer cells for protein synthesis Soy, sesame seeds, and brazil nuts are high in methionine Lowest: apple, most fruits Dark green veggies are fairly high Hard part is getting enough calories on a low methionine diet Potatoes and rice work to bring up weight 38:40 Cycling on and off low-methionine foods Encourage fruit-only breakfast (easily digested, full of enzymes, fiber, water, cleansing, detoxifying, extends a fast) Book: Harvey Diamond, Fit for Life Food combining Methionine restriction is anti-aging Ketosis is not necessarily a healthy state - not natural/normal Not a proponent of fasting for cancer patients - too stressful Recommends a fruit-only diet instead of fasting Super-charge your system by eating raw, high-energy, plant-based foods 44:30 What is the distinction between nutraceuticals and supplements? Use supplements to fill in gaps Recommends supplementing with iodine, selenium, vitamin D, zinc, B12 Nutraceuticals can be used to lower inflammation Sodium selenite is used as an anticancer nutraceutical Vitamin E delta tocotrienol- high dose kills cancer cells Glucosamine alters cancer cells High-dose zinc is effective in killing cancer cells Melatonin effective in fighting cancer (300 mg) Curcumin - plant derived medicine - not very bioavailable Medicines work because of toxic effects on system/system modulation 50:20 How did selenium and tocotrienols stand out to you? High index of therapeutic value High bioavailability Water solubility ADME Absorption, Distribution, Metabolism and Excretion - nutraceuticals are analyzed according to this standard Sodium selenite has reached animal and human clinical studies (in-vivo) Methionine restriction is being used in ongoing human clinical studies 55:20 What is the mechanism of action of sodium selenite? Selective pro-oxidant Study which shows it inhibits glutamine metabolism Natural high uptake into tumor tissue Radioactive sodium selenite (SE-75) was used in the 1960s to highlight cancer cells on imaging tests Relatively small amount of sodium selenite (10-20 mg) is typically needed at therapeutic threshold levels 9 hour half-life Cells need to be exposed 24 to 72 hours or more - the longer the better Lower doses can be sustained for longer periods of time .3 mg/kg of body weight is dosage for IV sodium selenite IVs are used for pulsing in addition to oral dosage IVs can become cost-prohibitive 1:01:30 Hazards of buying sodium selenite online Can be risky - might be over a toxic dose or too weak Mark sells some on his website Might not be pharmaceutical dose Signs of overdose Hair loss Brittle nails Use under supervision 1:03:00 Is this an extract of selenium versus a whole compound? Sodium selenite is a mineral salt - inorganic form of selenium- trace mineral Chemical formula Na 2 Se0 3 Body needs it all the time Organic forms vary in the level of anti-cancer activity 100% water soluble- easily crosses blood-brain barrier Vitamin E used is extracted from annatto seed - delta tocotrienol Pro-oxidant Looks and behaves like unsaturated fatty acid Initiates lipid peroxidase chain reaction Ends up in mitochondrial membrane Interacts with and generates more ROS Triggers cancer cells to die - apoptosis Mitochondria are dysfunctional in cancer cells Breaks the positive feedback loop of the mitochondria so cells can die 1:09:39 You mentioned DHA. Where do you get yours? Mark uses an algae oil Studies show DHA can be used therapeutically in cancer (6g/day) DHA will become incorporated into the cancer cell membranes and will undergo lipid peroxidase reactions Algae oil is unstable and oxidizes easily Antioxidants are added to maintain stability and this can be enough to interfere with NORI protocol 1:11:20 Budwig diet - similarities and differences Fruit, berries, no animal products Cottage cheese and flax oil mixture Flax contains ALA, a polyunsaturated fat Studies show ALA can trigger cancer cells to die Flaxseed oil must be freshly pressed (15-30g) Cottage cheese/quark works as an emulsifying agent to break up the oil for bioavailability Theoretically based on the science, it should work Not in favor of it right now because there are better methods Tocotrienol does the same thing only with more efficiency 1:15:30 Lithium Chloride Still under study Has a favorable effect on cancer pathways Used as treatment booster Studies with lithium chloride used in conjunction with 5FU in animals 1:17:07 NORI protocol is currently using 6 agents 3 core agents make up the cytotoxic cocktail Vit E tocotrienol (1200mg), sodium selenite, Vit K3 3 other agents working around the cocktail Glucosamine (8g), zinc citrate (150mg), melatonin (300mg) Used in conjunction with methionine-restricted diet Protocol is continually evolving based on clinical experience Simple, low-cost 1:19:10 Where can we find you? https://antibioticwatchdog.com/ Website covering relationship between antibiotics and cancer Free ebook https://norinutraceuticals.com/ (store) https://noricbd.com/ https://nutritionaloncology.net/ Info on program and protocol Mailing list CBD products and nutraceuticals - Use code STERN Free consultations (30-60 min) 1:22:00 Closing remarks Please check out the podcast links and the links on our website (“What We Use” section). Your patronage is greatly appreciated and helps keep the lights on. For more info about fruit in the diet and to view our most popular video, see Ryan’s podcast with Dr. Robert Morse. Link Below. Use your intuition and try different options if a current protocol is not working. There are many paths to wellness. Future podcast idea: feature two experts on opposite sides of a topic and let them discuss the pros and cons of each Please send your ideas for future speakers to info@anticancerrevolution.com As always, if you are going through cancer….just keep going! Related Podcasts Fruit, The Lymphatic System & Cancer: Dr. Robert Morse If you have a question or comment about this episode let us know below!!
No one is exempted from exposure to environmental pollutants. While this may sound worrying, there are steps, backed with scientific and empirical evidence, to rid our bodies of these harmful pollutants. However, there is still a lot of misinformation about detoxification that we need to uncover. In this episode, Dr Bryan Walsh discusses the common perception about detoxification and explains the actual science behind it. He talks about the different phases of detoxification and its complexity. Dr Walsh also tackles the importance of excretion as a widely ignored aspect of detoxification in diets and weight loss programs. Detoxification may seem challenging to start, but it begins with getting to know your body and blood chemistry. If you want to know more about the science behind detoxification, then this episode is for you! Get Customised Guidance for Your Genetic Make-Up For our epigenetics health program all about optimising your fitness, lifestyle, nutrition and mind performance to your particular genes, go to https://www.lisatamati.com/page/epigenetics-and-health-coaching/. You can also join our free live webinar on epigenetics. Online Coaching for Runners Go to www.runninghotcoaching.com for our online run training coaching. Consult with Me If you would like to work with me one to one on anything from your mindset, to head injuries, to biohacking your health, to optimal performance or executive coaching, please book a consultation here: https://shop.lisatamati.com/collections/consultations. Order My Books My latest book Relentless chronicles the inspiring journey about how my mother and I defied the odds after an aneurysm left my mum Isobel with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again, but I used every mindset tool, years of research and incredible tenacity to prove them wrong and bring my mother back to full health within 3 years. Get your copy here: http://relentlessbook.lisatamati.com/ For my other two best-selling books Running Hot and Running to Extremes chronicling my ultrarunning adventures and expeditions all around the world, go to https://shop.lisatamati.com/collections/books. My Jewellery Collection For my gorgeous and inspiring sports jewellery collection ‘Fierce’, go to https://shop.lisatamati.com/collections/lisa-tamati-bespoke-jewellery-collection. Here are three reasons why you should listen to the full episode: Learn about the phases of detoxification. What is the assessment criteria for detoxification? What is the importance of context in detoxification? Resources Try out a Metabolic Detoxification Questionnaire here. Alternatively, you can look for other questionnaires by searching for ‘metabolic detoxification questionnaire’. Detoxify or Die by Sherry A. Rogers Fasting Mimicking Diet Program by Dr Valter Longo Metabolic Fitness Curious to start your detoxification? Try out the Walsh Detox Program! Episode Highlights [04:47] How Dr Walsh Started Studying Detoxification Dr Walsh was interested in health and fitness from a young age. He eventually ventured into massage therapy and became a fitness professional. He took a postgraduate degree to become a naturopathic physician. After his education, he felt that he had to study more to serve his patients better. His goal is to connect conventional Western medicine and alternative medicine. [09:56] Views on ‘Toxin’ and Detoxification Dr Walsh cites some ridiculous notions surrounding detoxification. In the 80s, it used to be rehabilitation for addiction to alcohol and drugs until everybody started hopping on the ‘detox bandwagon’. Xenobiotic or commonly known as ‘toxins’ is something foreign to the body that can cause damage in excess. When water leaves the body in any form, water-soluble toxins leave as well. Meanwhile, the body still needs to turn fat-soluble toxins into water-soluble toxins to get rid of it. Our bodies are naturally built to detoxify pollutants through biotransformation. Listen to the full episode for an in-depth discussion on toxins! [16:11] Categories of Pollutants First is heavy metals. This category includes aluminium, arsenic and mercury, among others. Second is persistent organic pollutants, which include phenol, dioxins and pesticides. The last category is volatile organic chemicals (VOCs) that are usually inhaled. In essence, pollutants are everywhere. [17:41] Everyone Is Exposed While everyone is exposed to pollutants, the levels may vary due to location and lifestyle. For instance, Dr Walsh believes that athletes may be less toxic due to sweating during exercise. Listen to the full episode to know the body’s pathways for getting rid of environmental pollutants. [23:04] The Difficulty in Assessment Criteria There are a lot of variables and testing methods to consider in assessing toxin exposure. The fat biopsy is regarded as the gold standard test. However, because different body areas store different amounts of fat, there’s no consistency in the body. Taking these tests can guide you to make different lifestyle changes. However, keep in mind that they cannot determine your body’s toxicity level quantitatively by an absolute number. Listen to the full episode to learn more about the complexity of detox questionnaires. [30:00] Nature of Pollutants Toxin gets stored in a cell or area with low concentration. This is called the concentration gradient. If there’s more toxin in the blood and less in the cell, it will get stored in the cell. When fasting, you go into a catabolic state. Studies have shown that xenobiotics in the blood increase in this state. All detoxes are cellular detox. [33:43] The Phases of Detoxification Phase 0 starts with the fat-soluble toxin entering the cell. Phase 1 is the reaction with the addition of a hydroxyl group. Phase 2 concerns conjugation reaction of adding methylation, sulphation and the like. Finally, phase 3 is when excretion happens. Tune in to the full episode for Dr Walsh’s analogies and a detailed explanation of each phase! [42:06] The Three Pillars of Detoxification The keys of detoxification are mobilisation, biotransformation and excretion. Mobilisation is getting pollutants out of storage. Biotransformation encompasses phases 1 to 3. Excretion should take the toxin out of your body. [47:34] Effects of Dieting Dr Walsh recommends doing a weight loss program in conjunction with a detoxification program. During periods of weight loss or catabolism, xenobiotic levels increase. The problem with rapid weight loss and yo-yo dieting is the redistribution of toxins in the body without excretion. [53:22] Nutrients and Detoxification Being nutrient sufficient is enough to support phase 1. Phase 2 is driven by amino acids. Phase 3 can be blocked by three inhibitors: milk thistle, curcumin and green tea. However, note that the effects of these three inhibitors are based on its dosage and the context. One protocol will not work for everyone; you have to look at the totality. Listen to the full episode for more details about nutrients and botanicals! [1:05:00] The Nature of Symptoms For Dr Walsh, thyroid dysfunction may be secondary to another issue. Once symptoms show, you should consider if it is a protective reaction. [1:11:32] Advice for Detoxification Dr Walsh shares details about his detox course, including a practitioner-based programme and The Walsh Detox for the general public. Your blood chemistry is essential in determining your detoxification programme. 7 Powerful Quotes from This Episode ‘I’ll be the first to tell you that science will never prove some of the things in life that are the most important things — relationships and love and how we try to study how the brain works — and I don’t think we have any idea’. ‘This is part of my problem with the industry is we can’t even decide on what a toxin is. . . So what I would suggest, the one that people are most talking about, that’s why I think environmental pollutant or environmental toxins make more sense because usually what people are talking about are things that are outside of us that get inside of us and cause damage of some kind’. ‘They will test their blood, their urine and their sweat for a specific xenobiotic or environmental pollutant. And they will find in many cases, it’s not in the blood, it’s not in the urine, but it is in the sweat’. ‘Everybody’s toxic. Everybody needs to detoxify. . . It’s not necessarily exposure; it’s we all have some degree of storage. The question is, when somebody is not feeling optimal, is it because of that or not? And so you can’t run around screaming everybody’s toxic because I don’t know that they are’. ‘And so it’s [toxins are] concentration gradient-based, which also means so that’s how it gets stored. If there’s more in the blood and less in the cell, then it will tend to go into the cell. And that’s when it gets stored’. ‘There’s some ridiculous stories out there that will say, ‘The body won’t release toxins if it’s not healthy enough, and it doesn’t think it can deal with them’. That’s not true’. ‘I’m against protocols; because one protocol will be brilliant for one and harmful for another same protocol’. About Dr Walsh Dr Bryan Walsh has been studying human physiology and nutrition for over 25 years and has been educating others in health for 20 of those years. When he isn’t teaching, he spends his time poring over the latest research and synthesising his findings into practical information for health practitioners to use with their clients. He has given lectures to members of the health care industry around the world and consistently receives positive feedback in his seminars and courses. His online educational platform, Metabolic Fitness, helps health professionals to stop guessing and start knowing what to do with their patients. Dr Walsh is best known for challenging traditional dogma in health and nutrition concepts, such as questioning current models of adrenal fatigue, glucose regulation, detoxification, mitochondrial dysfunction and more. As such, he has been sought out to consult with multiple companies, academic institutions and wellness organisations. Dr Walsh is also a board-certified Naturopathic Doctor and has been seeing patients throughout the U.S. for over a decade. Outside of his professional endeavors, you can find him spending time and having incredible amounts of fun with his wife, Dr Julie Walsh, and five children. Enjoyed This Podcast? If you did, be sure to subscribe and share it with your friends! Post a review and share it! If you enjoyed tuning in, then leave us a review. You can also share this with your family and friends so they can learn more about the science behind detoxification. Have any questions? You can contact me through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts. To pushing the limits, Lisa Full Transcript Of The Podcast! Welcome to Pushing the Limits, the show that helps you reach your full potential with your host Lisa Tamati, brought to you by lisatamati.com. Lisa Tamati: Hi, everyone, and welcome back to Pushing the Limits. And today I have just a super superstar for you, Dr. Brian Walsh, who's sitting in Maryland in the USA. Dr. Walsh is someone that I've followed for a long time and learned from. He is one of the great teachers in biochemistry and physiology. And today we are discussing detoxing very relevant to this time of the year. And this is all really next level information. Because it's all about detoxing, like what are the actual physiological steps of a detox process? And what is the latest and current research. This is not something you read in a two page magazine article detox type of thing. But this is the real deal with someone who really, really knows his stuff. Now, Dr. Brian Walsh has been studying human physiology and nutrition for many, many years. And he spends his time sort of poring over the latest research and synthesizing all of that information for the layperson to be able to understand. And he also lectures at Western States University in biochemistry. And as a healthcare professional, he's a doctor of naturopathic medicine. And he has an online educational platform called metabolicfitnesspro.com, where he helps other health professionals like myself, and many, many others, as well as lay people with his programmes and courses. And we're going to be discussing today, as I said, detoxing, how to do it properly, when not to do it, what to be aware of if you are doing it. And he's you know—Dr. Walsh is someone who's really known for challenging traditional dogma in health. And he actually goes and does all the research, does deep deep dives into all of the clinical studies into PubMed, and then brings us the latest and information. So he's really someone that you want to have on your radar, someone that you want to know, if you want the latest and greatest in information. I hope you're enjoying your Christmas time, by the time this episode comes out, Christmas will have been passed. And we're into the new year. And hopefully the world is on a new trajectory and that 2021 is going to be a hell of a lot better. And what better way to start the year than with a discussion around detoxing and getting your body in good shape for the year ahead. So without further ado, I'll be heading over to Dr. Brian Walsh. And just a reminder too. If you want help with any health issues, if you are dealing with anything, please reach out to us lisa@lisatamati.com. You can reach me on email. If you're wanting information about our online run training programmes at Running Hot Coaching, want personalized run training, please do reach out to us as well. We just launched a new package that will be coming out in the next few weeks. So keep an eye out for that where we're going to be offering video analysis, as well as fully customized programmes and a session with me—all included in there in a package price. It's really really a no brainer. So if you want to find out about that, please reach out to us at lisa@lisatamati.com. Of course our epigenetics programme is still open, if anyone wants to know and understand the genes—understanding everything to do with your genes, eliminating the trial and error for your body, understanding what foods to eat exactly, which areas you're predisposed to have problems with, how your brain functions, what your dominant hormones are all of this sort of great information. Please also reach out to us and we can put you in the right direction. We've done a few webinars already on our epigenetics programme. And in the coming weeks, we're also going to be having Dr. Ken McDonald on from PH-316, who's going to be going a little bit more deeper into this. So I hope you enjoy the session though for now with Dr. Brian Walsh. And we'll head over to him right now. Lisa Tamati: Well, hi everyone and welcome back to the Pushing The Limits. This week, I am super excited. I'm jumping out of my skin. I have a man who I really, really admire. I love his work. He's got an incredible brain. Just absolutely mind-mind conversation we were going to have today. I have Dr. Bryan Walsh with me. Welcome to the show, Dr. Walsh. Dr. Bryan Walsh: Thank you so much for being here. Lisa: It's a really, really an honour to have you on. Dr. Walsh, you’re still in Maryland, in the States? Can you give us a bit of a background just on who you are and sort of a quick synopsis and your background as a physician, etc.? Dr. Bryan: Well, yes, I guess I should say it all started out, I was very much into health and fitness, even at a young age, quite honestly. I became a fitness professional—that’s how I started. And then I did a lot of orthopaedic work, so that led me to massage therapy. So I did massage and I was a fitness professional. And the problem is my clients would ask me health advice. And here in the States—I'm a law-abiding citizen—I could have talked to them about nutrition and supplements, but I wasn't allowed to with those things that I did. So then I looked—and there's something in the States, it's a naturopathic physician, naturopathic doctor. I know you guys have naturopathic there. They're a little bit different. It's a four year postgraduate degree. So you go to four years of university, and the traditional four years. And then you have your doctorate. That sounded really good to me because I was already into alternative health. I was devouring books, on health, on herbs, on homeopathy, everything in the health. And that was the umbrella for all these things that I was interested. And I thought, wow, that's great, perfect. So I went through four years of that. Spent way too much money. But it's also where I met my wife. So that is money rally well spent. Yes. Although we both went to school there. So we doubled our debt, essentially, by marrying each other. But what we quickly realized is that it didn't really prepare us to do what we wanted to do. And it didn't take long. I was sitting in front of patients, and I honestly—I didn't think I know what I was doing. I didn't feel qualified. I spent all that money over the four years of school with great classes, but it sounded like all these great topics but... And so that started me—and this is all to tell you this story— where I realized I had to teach myself everything, that I had to reteach myself physiology. I know we're going to talk about detox today. But how I stumbled upon that what I'll call is the truth about detox. And so where I am today is I believe in old medicine, I believe in the body heals itself. But Western science and Western medicine is incredible. I mean, we owe much of what we know about the human body, in terms of mechanisms and pathways and how herbs even work in the first place, to Western science. So what I tried to do is bridge the best of both, is to take the alternative nutritional functional health world, which is great for some things but horrible in others, and combine that with conventional Western medicine, which is great in some things, but horrible in others, and I try to connect the two. So I hope that gives you much of... Lisa: That’s brilliant. Dr. Bryan: I love science. Lisa: And I love the way you sort of combine the traditional or the alternative with the allopathic sort of model because they do both have good things, and they do both have problems. Dr. Bryan: Absolutely. And I can tell you, I love science. But I'll be the first to tell you that science will never prove some of the things in life—of the most important things, in relationships, in love, in health. We try to study how the brain works and I don't think we have any idea. We try to—we're doing genetic testing now, I don’t think… We talked about the microbiome, I don't think we know much of anything when it comes to these things. So, science is fascinating. It's so fun. It can occupy you for hours upon hours upon hours of reading and the rabbit hole of PubMed, but I don't think it will ever offer some of the answers. So that's kind of where I live is that we live in this expansive universe full of all sorts of possibilities. But here on Earth, science really helps us a lot understand certain things, but it doesn't contain all the answers. Lisa: It's a very humble approach. And I think a really good place to start because we know a lot, we don't know a lot more. But we have to sort of work with what we've got and the best knowledge. And this is something that I've really enjoyed out of like, I think I've devoured everything I could find on the internet of yours. And I must say sometimes, I'm like my brain is spinning, trying to keep up and it's fantastic. And I was talking to a colleague who's also really into you and he's got a master's in physiology and he said, ‘Well, I struggled, too, so don't feel bad’. But you do have a way of putting things into analogies that I have just found absolutely fascinating. And today we're going to go into detoxing. And there is an analogy in this story that I've heard you speak of a couple of times that really went, ‘Aha, I get it now’. So definitely want to delve into that analogy. But so just to start with, with detoxing. Let's look at what detoxing in the public realm—if you like—in the popular—the magazines. People talk about detoxing a lot. And I think that we don't understand what detoxing is. So let's start there. What is a proper detox? Dr. Bryan: So what you just described, that's the problem. It's a mess. I was just in the checkout line at the grocery store, two days ago. I even took a picture of my phone to send my wife and it was like, ‘A faster way to do a liver detox’, and it was some medical doctor. I thought, ‘I'm not even going to open that magazine. It's going to be garbage’. You’re right. People say, ‘drink a little bit of lemon juice in the morning, and that's a great way to detoxify the body’. And then I was in the airport one day, and I saw these foot pads that you put on your feet to help pull toxins out of your feet. And then there's the foot pads, and there's colonics. And there's all these different things, and that's why conventional medicine doesn't believe any of this because you have these people saying, ‘Well, when you skin brush, then you're detoxifying yourself’, maybe, maybe not. But no wonder they think that we're a bunch of quacks because if you stand back and look at all that nonsense, it does look like quackery. In the 80s, detox, the only detox there—unless you were like a hippie—in the 80s, was like a celebrity going through some kind of rehab for some kind of addiction, alcohol or drug addiction, then they would go through some kind of rehabilitation, so that was a detox. That was the only detox there was. And then all of a sudden everybody started getting on this detox bandwagon. And the thought is that we are bombarded with—we’re basically these toxic waste cesspools of disgusting that’s inside of our bodies, and the only way to get rid of it is to do these to detoxify. Now, there's some truth to that, some truth. But our body is designed to—a better way to say detoxification is biotransformation, first of all. So there are two different types of we'll call—I don't even like the word toxins, quite honestly. You can call them xenobiotics, starting with it with an ‘x’. Xenobiotic means it's something foreign to the body. You can also call them environmental pollutants, environmental toxins, whatever you’re going to call it. Some people say synthetic, but that's not true because Mercury is toxic to the body in high amounts. So, for lack of better terms, we can call them toxins, xenobiotics or whatever. But they're things that are foreign to the body that in excess can cause damage. There's essentially, for simplicity sake, two forms, there's water soluble, and there's fat soluble. Water soluble, by and large, I don't think we have to deal with too much, because our body is really good at getting rid of it. Our body is so much water already, we don't have to do anything to it. If we have access to something that's toxic, and it's water soluble, our body's pretty good at getting rid of it. And when you look at the ways of getting rid of something, it's anywhere that water goes. So sweating, obviously, urinating, it's quite a bit of quite a water. In faeces, there's a small amount of water that gets expelled there. And even technically—and people have measured this but in tears or saliva, you can get rid of toxins too. So anything where water is leaving the body, then water soluble toxins are leaving as well. And I personally believe that those aren't much of a concern to us because our body... It's kind of like if you take a whole bunch of B vitamins. Technically, those can be toxic in high amounts but they're water soluble in your urine turns glow in the dark yellow if you take too much of that because your body is getting rid of it. Same with vitamin C or any of the water-soluble vitamins. Interestingly—and I hadn't thought of this as a way of describing this, but the vitamins that they say to be careful with are the fat-soluble ones like vitamin A, D, and K because they can accumulate and then those are the toxic ‘vitamins’ if you look at conventional medicine. So fat soluble toxins, those ones are more of concern because they can get stored and the body has to work a little bit harder in order to get rid of them. In other words, you have to take something that's fat soluble, turn it into something that's water soluble, and then the body can get rid of it and all those pathways that we talked about. So the body has built in detoxification or bio transformation processes—everybody says it's the liver but it's not. The enzymes and steps necessary for this are found in a number of tissues and in quite a bit. So, things that have exposure to the outside world, the skin has this disability, the liver does, the kidneys do, the lungs incidentally do, the testes in a guy does when we consider the location as exposure to the outside world more so than some of the internal organs. And we can go into the details of this but basically this fat-soluble toxin that can cause damage to the body gets metabolized or bio transformed, turned into a water-soluble toxin, if you will, a compound. And then is easily excretable in—again sweat, tears, saliva, urine, or a little bit in faeces. So yes, that's kind of a nutshell version of it, I think. Lisa: Okay, so. So let's look quickly at what are toxins and what sort of a fix they have in the body? So we're talking things like your heavy metals, your Mercury's that you mentioned, your pesticides, your preservatives in your food, there's chemicals that were exposed to. Dr. Bryan: So that's honestly—this is part of my problem with the industry is we can't even decide on what a toxin is because the toxin if you think about it, a toxin is something that could cause damage to the body. Right? So then you could say a reactive oxygen species or oxidative stress is a toxin, technically. Hormones, if you have too much of a hormone, can that cause damage to the body? It absolutely can. So, then all of a sudden is a hormone a toxin. And so that's where we start to run into problems, is that we just throw out these terms like toxins. Well, what is that something that? Something that damages the body? Well, a hammer, if you hit me on the head is going to damage my body. Is that a toxin? Let's say, oh, it's internally. All right, well, so how about lipid polysaccharides from a gram-negative bacteria? That's an infection. Is that a toxin? Yes, it is. So that's our—aflatoxin, you have mould in your house. And so, it ends up being this really broad term that people have a hard time describing. Now, so what I would suggest. The one that people are most talking about, that's why I think environmental pollutant, or environmental toxins, make more sense because usually what people are talking about are things that are outside of us that get inside of us and cause damage of some kind. And there's three, let's just say major categories of that there's actually more. One would be things off the periodic table. So that's the heavy metals, by and large, so aluminium, arsenic, mercury, all those types. Even copper, copper is toxic. Iron is toxic. Then there's—loosely the category that you can call persistent organic pollutants. And that's all the ones that get all the press, like this phenol and phthalates and dioxins and all those different things, pesticides. And then there's the ones that you could call them volatile organic chemicals, or VOCs, those ones are usually inhaled. So, you paint, you’re repainting your house, or your apartment and the smell that you get, or cosmetics or toiletries, cleaning products. If you buy a brand new piece of furniture and that off gassing, carpets. So those are the— mean, there's more, but those are the three major categories that I consider so... But then you consider where those come from, in the food that we eat, in the water that we drink, in the air that we breathe, it literally is everywhere. Lisa: Yes. So we are toxic. Dr. Bryan: Well, yes. We are. And I long time ago would say that we're all toxic, and everybody needs to detoxify. And I've tempered that a little bit because like for example, there's one published paper that suggests—well, okay, I should take a step back—everybody is exposed, everybody is exposed, period, end of story. To prove otherwise, I would need to see that proof. Now, it's going to be different considerably, however, based on your location, where you live. In New Zealand versus America. Here in America, I'm in Maryland, but that's going to be a lot different. I'm near farmland. So, we might have exposure to pesticides, but not so much some of the other things that might have been more of an urban area. In New Zealand there’s other different things. So also that depends on one's lifestyle. So me and my family largely eat organic food as much as possible. We use—I don't say green cleaning products, but we use better cleaning products than just the standard things. And so we probably have less exposure than somebody following a standard diet using standard toiletries, cosmetics, yes, and all those different things too. So, we all have exposure. Yes, that's it. I think I believe that's irrefutable. Is it stored in all of us? And I'm going to go ahead and say yes, but to different degrees. For example, you said you're a professional athlete. You have sweat a lot more than the majority of people. There's also some really interesting evidence showing that exercise actually upregulates certain detoxification or bio transformation enzymes. So you might actually be more adapted to that. Lisa: Another good reason to do it. Dr. Bryan: Absolutely. You know what? It’s so funny, like, you know you're supposed to, but then you just see more and more reasons. And it does, it absolutely has been shown in papers, to upregulate certain detoxification enzymes. In addition to the fact that you're sweating more so than somebody who's sedentary. So, I haven't seen any literature on this, but I believe that most athletes are probably less toxic than the general public. Lisa: The sweat is also a preferred pathway for some of the toxins to leave the body. Dr. Bryan: If used badly, yes. The skin has been called the third kidney before, which is kind of a cute thing to call it. I mean, is it or is it not? I mean, it's not like you're urinating out of your skin. So that should be gross. Next time you sweat, think of that. No, but it's a major excretory organ. And I will add this, there's some really interesting, really interesting scientific papers — small, unfortunately, not a lot of money in this industry to test this stuff. But they will take a group of people, and they will test their blood, their urine, and their sweat for a specific xenobiotic or environmental pollutant. And they will find in many cases, it's not in the blood, it's not in the urine, but it is in the sweat. Lisa: Exactly. Yes. The preferred pathway, yes. Dr. Bryan: That's an indication that a) it's being stored and b)... Yes, whether it's a preferred pathway or not, what that means to me is that it's probably stored in the tissues. Because you think about the blood, the blood is circulatory and it's bringing things around. The kidneys are filtering the blood. So, if it's not in the blood, that makes sense, it's not in the urine. What that means is it's stored. It's if it's not coming out in the urine, that means it's not in the blood, that means it's stored in tissues. And so, it isn’t going out. So whether it's preferred by the body or not, I don't know. But that just means that it's right there, right close to the tissues. Lisa: Yes, In coming out. Dr. Bryan: Right close to the periphery, and it's coming out via the interstitial fluid and stuff surrounding itself. But here's another thing to consider, too, when you talked about the demographic of the population that listens to this is, while most athletes probably have less—I mean, when it gets a broad state, you can't say yes, might have less because of exercising, because of firing. But are they exposed to something more than might somebody else be? So for example, if they're drinking out of plastic bottles that have been warmed up sitting in the sun all day, like might they have more excess pollutants... Lisa: More BPA... Dr. Bryan: ….these people are outside exercising in polluted area. Lisa: Exhaust fumes. Dr. Bryan: Exhaust fumes. I mean, you think about your respiratory rate when you're exercising, your respiratory rate is quite a bit higher than somebody who's sedentary. So then all of a sudden all those... Lisa: And oxidative stress Dr. Bryan: Yes, absolutely. So there's a lot of factors to consider for sure. Lisa: Yes. So we've looked at—these are the broad categories of toxins. And yes, we're probably all toxic, and we need to be doing or thinking about doing a detox—I don't want to say protocol—but to thinking about it constantly detoxing. And you touched on the couple of studies here where they measure the sweat, they measure the urine, and so on, and they got different measurements for different things. That's one of the problems, isn’t it? The assessment criteria. Because obviously, if we're doing a detox, we want to be able to assess, are we actually getting—and when you dived into the literature of assessments in defining out which is the best—how do I see if I'm toxic? What did you find in the literature around all the assessments? Dr. Bryan: So in the functional medicine world, there's no shortage of—well just tests in general and really attractive, good looking tests that when you look at them, you want to run them. Like, ‘Well, I would like to run this on myself. forget my patients or clients I want to run these tests’. The scientific validity on a lot of these tests is not there at all, despite what people might say or think. Yes, so I'm not opposed to testing for toxins. But there's so many variables to consider, and the practitioners that are running them, I don't think are considering these. So I think a lot of people are using them—they're wasting their money on them because they're not considering all these variables. So, for example, the first question to ask is, ‘what tissue do you test’? Do you test the blood? Do you test the urine? There are hair tests. Technically, in the literature, they test fingernails for toxin exposure. There's so many different ways of testing–fat biopsy, you want to take a needle into your fats, take some of it out and test that. And actually—I'll say since I said that—fat biopsies are considered to be the gold standard for internal toxic burden, and that would make sense if that's where they're stored. But the problem is, according to research—and this is done on humans, mind you—that different fat depots in the body store differing amounts of things. So, you might inject it into your, your, your butt fat, and find a whole bunch of one thing, and then you do it to your abdominal fat, and you come up with a higher amount of something else. So, if that's the gold standard, and you can't even have any consistency in the human body, then that's not going to be accurate, either. And if that's the gold standard, then that's not accurate, then none of them are going to be accurate. So, the short version is there are some—I guess I'll say, like validated as much as you can questionnaire—subjective questionnaires that one can take and get an idea of how toxic they may or may not be. Now, it's not quantitative. It's quantitative in the sense that you get a numerical value for the score. But it's not quantitative, in terms of like, This is how toxic I am. I am 80% toxic out of 100’. It's just a subjective questionnaire. But if somebody were to take a questionnaire like this, and scores high... Lisa: We've got a problem Dr. Bryan: ...and then does a few detox rounds or whatever, for a few months, six months, nine months, whatever it is, and then does it again and their scores are lower, that's good enough to suggest that they're doing better. And what's interesting about some of these questionnaires, is they not only asks things like, ‘do you live around industry? Do you have exposure to petrol or to gas’? But your symptoms as well. And so it takes all of these considerations, like, ‘Yes, I live and work around a lot of chemicals, but I don't have symptoms’ versus somebody that has a whole bunch of symptoms that are associated with toxic exposure, but they don't live around them. So, it does—they really are comprehensive. Lisa: I’d like to get a couple of the links to those if we could possibly see. Dr. Bryan: And listen, it's free. That's the very nice thing. You don't have to spend 300 US dollars on some blood tests that may or not be accurate. And what people are really interested in is, ‘how toxic are you’? Well, if my surroundings and my symptoms suggest that I am, based on these questionnaires, that's good enough for me. And as opposed to test, if you do it six months later, and it's approved, then I think you're probably doing a little bit better. Lisa: It's a little bit like your cell blueprint, which I found brilliant, by the way, and if anyone wants to check out that we can put the links. That questionnaire that you've developed there gives the practitioner the direction to go and we don't have a specific, ‘This isn’t definitely but hey, you might want to check your thyroid. Hey, you might want to go and check if you've got a parasitic infection, or whatever the case may be’. And I find that a brilliant system really. Dr. Bryan: But isn't that what a practitioner wants to do? I mean, the patients come in, and they want to know, ‘Well, where should I head first’? And detox questionnaire—and again, so everybody is exposed period, everybody's exposed. Everybody has some degree of storage. Now, I don't know how much. They might be really toxic. They might be cut. Who knows? But everybody has some degree of storage. The question is, then, is, ‘Are your symptoms—because of xenobiotic exposure—are in storage or not’? And that's where these questionnaires come in handy. If you take a questionnaire like that, and I mean, because there's people out there, believe me, there's plenty of them. Everybody's toxic, everybody needs to detoxify. There's an old book called Detoxify or Die. I mean, if that's not scary enough. It’s a good book, but I mean, it's not necessary. So we all have exposure, it's we all have some degree of storage. The question is, when somebody is not feeling optimal, Is it because of that or not? And so you can't run around screaming ‘everybody's toxic’ because I don't know that they are. But if you score high on one of those questionnaires, then that's the direction you'd want to look into. And if you score low, I mean, listen, people will still argue it, ‘Well. We're still all toxic’. I wouldn't go down that road. It wouldn't be the first thing that I’ll thought about. Lisa: It’s not your first protocol Dr. Bryan: Oh, no. The questionnaires... Absolutely. Lisa: Yes, I think that's what I do as a practitioner too, as epigenetics practitioner, and a health coach, is go for the low hanging fruit first. Because we can go in 100 directions and I can confuse the hell out of my clients and they can be like, ‘what the hell am I doing’? But if you are going for the ones late tackle, best piece of the puzzle, and then work your way up the food chain is so to speak—and actually find out which ones are the most important. Dr. Walsh, I mean—we're going to put the links in the show notes—you've developed your own detox system if you like, which I'm really keen to share with everybody and for them to check out. But let's go in now to the actual four phases of detox: zero, one, two, and three, and you have four, isn't it? In most people—or some people are at least aware of phase one and two detox within the cell. And when I first heard you talk about this, I was like, ‘Wow, okay, there’s a zero and there’s a three’. Okay, can you explain in a nutshell, what the body does when it gets a toxin? It's in the blood for some reason, it's gotten there. What actually happens next in these detox phases? Dr. Bryan: All right, well just to make it really comprehensive. I'll tell you, when you said when it gets into the blood, what happens? So when it gets in the blood, it can be detoxified, biotransformed, and excreted. But the best way to describe this is, so if it's in the bloodstream, wish I have something to sort of model this with but so like, so the bloodstream, and then you have you have a cell next to the bloodstream. Now there's—in physiology, there's what's called a concentration gradient. And these membranes… And so let's say we have the bloodstream in a tube—I really wish I had some kind of props here. I’m looking around. I have—my son has a Santa hat, razor blade, I don't know, I don't have much around here. Anyhow, so you have the bloodstream and here you have a cell. Now, if there's more in the blood of this, whatever it is, and less in the cell, it will tend to go into the cell. And it's usually fat cells, because it's fat soluble, it will tend to go into adipocytes or fat cells. And so it's concentration gradient based, which also means—so that's how it gets stored. If there's more in the blood and less in the cell, then it will tend to go into the cell. And that's when it gets stored. There's a really, really cool paper that discusses how adipocytes used to be considered to be just an energy repository, but then turned out to be an organ because they excrete over a hundred different things. But one of the additional roles they suggest is that it is this. It is to store toxins or xenobiotics, or things that could otherwise damage the body—they're fat soluble, which would make sense. Now, if that's a concentration grid. Now let's say we're in a fasted state, and we haven't eaten anything and or exposure. If there's less in the blood, and more in the fat cell, then it will leak out. And it's based on a concentration grade, it's based on homeostasis. There’s some ridiculous stories out there that will say, ‘the body won't release toxins if it's not healthy enough, and it doesn't think it can deal with them’. That's not true. What I've seen is that it leaks out from a homeostasis for a concentration gradient if there's less than the blood and more in the cell. So we are constantly leaking this stuff into our blood, if it's stored. Now this gets amplified. And I talked about this in the course, during lipolysis. So in a fasted state, in a catabolic state—not even not even losing fat, but just in a catabolic state which we go through at night. So if you stop eating at 8pm and you're sleeping, you're in a catabolic state, for example. If you're in a state of fasting, or lipolysis, then that's going to speed up mobilization. So now—and all the studies I've ever seen on mammals or humans show this. In a hypocaloric state, or fasted state levels of xenobiotics go up in your blood. And I'll say it again because that's huge. In a fasted state or a hypocaloric state, like dieting, then if there's stored xenobiotics, it will dump into the bloodstream, and those levels go up. And they always show that every single time because that's a state of lipolysis as a catabolic state. So then now we're back in the blood. So whether it's at an immediate exposure, or it was just released, the rest of the story remains the same. So then what happens? And I should just say too, I mean, I get frustrated with pieces of the industry. There's some people that will say, ‘Well, it's not a detox if it's not a cellular detox. If you don't detox yourself, then you're not’... This happens at the cellular level, as all detoxes is a cellular detox. So what I'm about to describe next is the cell. So let's say we have that xenobiotic it's floating around in the blood, we either just had exposure, or it came out of a fat cell. So in one of the cells, like the liver, the kidneys, the skin that we said has the ability to do this, there are four phases of detox. So if you picture just a cube, all I have is a mug, but I have a cube. Then there needs to be a door coming in and a door coming out, that's going to be two of the phases. And then once it's inside, there's two other things that are going to happen to this. So here's our cell, we have a fat soluble compound—I'm looking around for some—we have a fat soluble. Lisa: It’s like your room, isn’t it? Dr. Bryan: Well, that's the way that's why I've said it before. So yes, I mean, you could just use it as that. So in the room that you're in, or even a car quite honestly would work. So if you're in a room, you’re the cell, that's the cell, let's just say it's a liver cell. So when the door opens, that's phase zero detoxification. That's an actual phase. It was recently discovered in the early 2000s. Most people haven't heard of it but it's legitimate, things can block this. So if that happens, then that's a problem, clearly. So phase zero is when the door opens and the fat soluble compound comes into your room, into where you were. Lisa: Into the cell. Dr. Bryan: Into the cell, right. And once it's there, it has to go through two phases of detox. And you said I use analogies—quite honestly, I kind of make them up on the fly. Lisa: That’s awesome. Dr. Bryan: Well, I mean, I don't even know what I said. But I think in the past, what I've said... Lisa: It was an angry dude—a person—we make the person a toxin who’s just entered the room. Dr. Bryan: Oh yes. All right. I make him up on the fly until now. So all right, yes, yes, I can go with that one. So you have the room, the room’s a cell, a person is on the outside of your room, they come in, that's phase zero. And that's all it is in the cell is just a little protein tube. So the person comes in, they're fat soluble person. And they're angry. So what did we say? Lisa: You stick a sticky note on the head. Dr. Bryan: Is that what I said? Lisa: Yes. Dr. Bryan: Let’s make them more mad. That's right. Okay. See, listen, I'm telling you make it up right then and there. All right, you're right. You're right. You're right. So the person comes in, and they will damage your room. But to incite them and make them even more angry. Yes, that’s right. You put a little sticky note, like what was your little yellow sticky notes, and you put them on the forehead, that makes them really mad. Even more mad than they were in the first place. And now you can calm them down. But if you don't, they're going to start flipping over your desk, and just totally, totally worse than they were in the first place. They were angry when they came in. But now they're even angrier. But you can hand them a $100 bill. And they're going to say, ‘All right, I was angry but now I'm not anymore. I'm good. You just handed me something. So I'll go ahead and quietly leave the room now’. And then when they walk out another door of the room, then that would be phase three. So to put that—and thanks for reminding me of my analogy. But biochemically speaking, so you have a fat soluble compound, like a phthalate or a dioxin, or whatever it might be. So it literally has to get in the cell in the first place. Now, researchers used to think it was a fat-soluble membrane, fat soluble compound, and would just go right in. And that's not the case. It needs a channel in order to bring it in. That's phase zero, literally it is phase zero. And why is it phase zero? It was because they discovered this after they already knew about phase one and phase two, but they didn't have any numbers before then and they didn't even know it existed. So in the early 2000s, they said, ‘Well, we'll name it phase zero’. So that's the entry of a fat-soluble toxin, let's just say into hepatocyte, liver cell. Phase one: reactions. There's a few different kinds. They’re like oxidation reduction type of thing, hydrolysis. Basically, what happens is that when in the sticky note what it had on it, it had an OH, hydroxyl group. So you put a hydroxyl group on this person, or you exposed a hydroxyl group that was already present but wasn't fully exposed. Now the problem is after we put that sticky note on their forehead, and they got even more angry is that toxin beforehand could cause damage to the body. It could cause oxidative stress or DNA damage or endocrine disruption or citric acid cycle, mitochondria, whatever was unique to that particular toxin. But now that it has OH exposed or added on to it via phase one, it is water soluble, first of all. It's water soluble, which is cool. Now your body can get rid of it. However, it's considered to be an intermediate metabolite, and is considered to be more damaging than the original xenobiotic. Now, it's not true of every single time. And that's the thing, there are too many of these compounds to make blanket statements. People will say it's more toxic. No, it's not. It may be more damaging—I'm not going to say more toxic. It may cause more damage now that it's water soluble with this hydroxyl group exposed. But then phase two, when you handle this angry—now really angry person, a $100 bill US dollars. I wouldn't let you guys—you hand them a $100 bill or a bunch of money, they're not angry anymore. They're still water-soluble, they were but now phase two is considered a conjugation reaction and conjugation is adding something to it. And so people that are familiar with phase two are familiar with things like methylation or sulphation, or glucuronidation, or amino acid conjugation, any of those things but what gets handed is this: so sulfation, you hand them a sulphur group, methylation, it hands them a methyl group, amino acid conjugation, it's usually glycine, glycine will go, glutathione conjugations glutathione, so acetylation and acetyl groups. So the xenobiotic gets handed to it, what's unique to that particular one, if that makes sense. You can make it really easy to talk about hormones like sex hormones, go through the same pathway—the testosterone, the estrogen. They go through the same pathway. Lisa: They do, and neurotransmitters as well. Dr. Bryan: Yes, cytokines, immunoglobulin, antibodies Lisa: And dopamine and all of that? Dr. Bryan: Yes, by and large, by and large, yes. So then it gets phased two. It gets something handed to. Let's say, it gets a sulphur group and went through sulfation. Now, it's no longer damaging to the body. Now it's relatively benign. It was damaging as its original compound. It came in through phase zero, it was made potentially more damaging by exposing or adding on a hydroxyl group, depending on what the compound was, and depending on the biochemical pathway went through, but then when it gets conjugated, it's still water soluble, but now it's not damaging. And can there—if phase three, that second door is open, can go out of the door. Now remember, so all that does—and this is a really important part—there's a lot of misunderstandings of what phase three is. Phase three is merely a tube, leaving that cell, which means that, this thing now, in terms of physiology goes into the interstitial fluid surrounding cells. Lisa: And it’s water-soluble at this point. Dr. Bryan: It’s water-soluble in the interstitial fluid, and can be excreted in sweat. It can go through the lymphatic system, which is going to pick up some of the junk of the interstitial fluid but that just dumps itself in the bloodstream anyways, which that means it'll probably end up in the kidneys and get excreted out in urine. But a lot of this can end up going in—since it happens in the liver, the liver will get rid of its these... Lisa: ...products Dr. Bryan: ...through bile because the route from the liver to the intestines is via bile. Lisa: Why is this not phase four, then? Like phase three should be the thing leaving the cell. Dr. Bryan: It is, that's phase three. Lisa: Phase four should be like actually the excretion method. Dr. Bryan: You can call it phase—or at some point, you're going to have too many phases. You’ll be like, the 10 phases of detox. It will just confuse everybody. But after it leaves the cell, the most critical piece is excretion. And I mean, we're not talking about this part yet but I'll just say, the three pieces, there's four phases to detox. But the three things that must happen for somebody to actually detoxify, and I say must with a capital MUST, is one is they have to be mobilized. You have to get them out of the storage in first place. Two is you have to go through biotransformation, which is the phase zero, one, two, and three. The third part is they have to be excluded. If they're not excreted—and this is a really important part—if it's not excreted, it can go into another cell. That conjugation reaction that can get undone, there are enzymes that will undo that conjugation. So you handed this sulphur... Lisa: You’re backing in the shot again basically. Dr. Bryan: Well, and then it becomes this damaging thing again, and can get stored in another tissue if it doesn't get excreted, which, incidentally, is why I have a major problem with most fasting programmes. Honestly, most weight loss programmes in sedentary people. I mean, if you take a fitness competitor... Lisa: An athlete’s all right, they're going to sweat it out. Dr. Bryan: They'll probably be okay. But if you take somebody who has just been storing their whole life, they've never really exercised, they get to be 45 years old. They wear a certain weight during their wedding. Now, they're 45, they don't feel sexy anymore. Maybe it's a good time to do a real weight loss programme, the chances of them flooding their system with these things is tremendous. And if there is not an active role in, especially that's the mobilization, that's the first part. But to properly detoxify these, and more importantly, excrete these things, then it's just going to go somewhere else. And I will say there's some evidence. It's weak evidence, unfortunately, there's not a lot of research on this, but midlife weight loss might be associated with an increased risk of things like dementia and certain chronic diseases. Lisa: I want to sit on this topic a little bit and dive into, because I had some questions when I started to understand this whole process, it really rang some alarm bells for me. For people who do like yo-yo dieting, they're losing weight, they're gaining it, they're losing weight, they're gaining it. They're actually doing a lot of damage than somebody who's just lost it. Another thing is if you're losing it slowly over time as compared to just dumping it all because you've done a juice fast that someone told you was a fantastic detox. And then you've dumped all this into the system. And this can have impacts years later, like we just mentioned, like dementia, Parkinson's disease, all of these things. Because I was listening to one of your biochemistry or blood chemistry lectures, I can't remember which one, something to do with cardiovascular system. And you were talking about the triglyceride molecule, or whatever you call it. And how—if the legs are broken off—it’s free fatty acids get into the system and then this can clog up the system, cause insulin resistance, be a contributing factor to diabetes, all of these things. And I was like, ‘Whoa, whoa, whoa, whoa. So, when I'm losing weight, which I think is a good thing for my body, I'm actually also doing some damaging things because I'm releasing these toxins or these free fatty acids or, or things that are actually causing trouble’. So when we have a detox programme that's in the latest magazine, and even some of the scientific like Dr. Valter Longo’s Fasting Mimicking Diets, which is a great—lot of research gone into it, but it's looking at the mobilization, the autophagy, the mitophagy, all of these good pieces of the puzzle, but it hasn't actually considered the excretion. It does look at the micronutrients required for phase one and two, which is fantastic. So you've got three pillars here that you're talking about. First is mobilization, of the fats or the toxins into the bloodstream from stored places, like your fat cells. Then we've got phase one and two, where it's processed, the detox—actual detox situation. And for that, we need a whole lot of micronutrients, which I want to touch on briefly like using your selenium and your B vitamins and goodness knows what. If you don't have those—your sulphur groups. If you don't have those, you're going to have trouble. And then we need to look at how do we get this stuff out. So what can we do to support the body to do binders or I don't know what the sweating protocols or saunas or whatever? I had one question that for me personally, I've got a mum that had a massive aneurysm four years ago, and my listeners know about my story. I've just written a book about her journey back for massive brain damage. Now she's lost 30 something kilos over this last four and a half years, when I have been rehabilitating her. She does not sweat. And she's 79 years old, she's never really sweated. She doesn't do that very well, naturally. And she also now at 79, can't exercise intensively enough to sweat. I can't put her in a sauna because here temperature regulation has gone with her brain function. I have to be really, really careful, then if I make you lose any more weight, don't I? With brain damage... Dr. Bryan: Well, it’s a hard thing to say for sure. I mean, first of all, with all that weight loss already—I don't want to say the damages—you have no idea. Lisa: Yes, so hopefully it was not a big dump. Dr. Bryan: Yes, so there are some interesting human studies, looking at slow versus more rapid weight loss and how much xenobiotic levels go up, and how it affects thyroid hormone, and the basal metabolic rate and all these different things to which is their recommendation is to do slower detox, but like I said, I would recommend how about, I mean start a weight loss, I would support doing detoxification pathways while you're doing the weight loss programme so that you can get rid of these things better, and it doesn't cause damage. Yes, so in terms of yo-yo dieting, again everybody's a little different. I can't say this happens to everyone. It depends on your diet, your lifestyle, where you live, and how much you've accumulated. I mean, some people don't have a whole lot, I would suspect. But yes, so there in fact, there is at least one study that comes to mind using mice and yo-yo dieting. And what basically it showed with them is that during periods of weight loss or catabolism, that their xenobiotic levels would go up. And then when they stopped in the hypocaloric state, they went back into a more of a hyper caloric state, that the xenobiotics that weren't excreted went somewhere else. And when I mean somewhere else, like a different tissue, so it absolutely can go from one tissue. Absolutely. Absolutely. In fact, I wanted to tell you this. Anecdotally, I just talked to a guy—I don't know about a month ago—who used to work at a water fast detox clinic in Thailand. And he worked there for a really long time. And he's said that their people would fly to Thailand to go to this water fast detox clinic that had no business to do so. They were not healthy, it's more of a novelty. Like, ‘hey, let's go to Thailand and go to the water fast place for two weeks and do a detox, then we'll go back and live our life normally like we did before, eating a bunch of garbage’. And he said, they had no business doing it, but they would come back once or twice a year. And the same people he said would get worse, that I mean, and horrible, like liver problems or teeth were falling out, and just wrecking them. And it was fascinating to hear that story. He didn't know why. Lisa: Yes, and I can guess why. Dr. Bryan: Well, that's what I mean is to actually have real world experience, possibly. There's no proof of this, but to see these people that would do a one week, two weeks supervised water fast and then come live their life and then come back, and their health was worse. And I think if I had to bet I would say that's probably why. And consider, it's just a water fast. So what were they not doing, is they weren't exceeding, they weren't sweating. They didn't take any binders. They weren't doing anything. All they were doing is just water. And so, to me, they were flooding their system in a very—almost completely fasted state except for water, which is essentially fasting. Flooding their system, potentially with xenobiotics, not excreting them all and then reabsorbing them, putting them in different tissues. Lisa: Re-depositing them in your brain or something. So you could shift the mercury molecule, for example, from your fat cell where it was pretty safe. Put it into your blood and then it get redeposited in your brain and cause real strife. Dr. Bryan: And he hasn't contacted me yet. I think he will probably be angry. But Dr. Longo you mentioned, I mean, the guy's brilliant. He's brilliant, he’s great. Lisa: Oh, yes, no doubt. Dr. Bryan: And it's super, super cool what he's doing, that's a huge concern that I have, though: is that you take an average person and you put them on what's essentially like, what 300 to 500 calorie diet for a period of time, and if you don't support the biochemical—so that's mobilization for sure. If you don't support the second part, which is detoxification pathways, and then the third pick is excretion, then you're potentially making them worse longer. And again, who cares about autophagy and mitophagy if you're just redistributing these xenobiotics somewhere? And it’s a huge concern. It's a legitimate one. And I’m not saying what he's done is bad, I just think it's a piece that is missing. Lisa: A discussion needs to be had around this. Dr. Bryan: Yes, well, and that's true of... So, take the Gwyneth Paltrow juice test. It's the same thing. You're not binding or excreting anything. You're hypocaloric, yes. Are you improving detoxification? Well, not if you have things like celery and carrots because those might actually inhibit as it turns out. So you're not detoxing. So you're mobilizing, not detoxifying and not excreting—that's bad news, I think, long term. Lisa: Well, let's look—talk about a couple other things that are in the phase one and two, in phase three, actually, more specifically. Some of the compounds that we consider great compounds for a lot of things, like you mentioned celery and carrots. I mean, that's what people juice with. I mean, I know I just had a celery juice for breakfast. I'm not into detox, but celery in itself is not a bad thing. But it can be a mild phase three. I believe inhibitor is in curcumin, milk thistle, some of these things that we consider detox herbs, if you like, and especially in supplement doses versus food doses can actually have the opposite of fate. Can you go into just a little bit of that, what nutrients support phase one and two and three, and which one's actually inhibited? And why is it counter-intuitive? Dr. Bryan: Well, the counter intuitiveness of it has to do with the dose, turns out. So well, and again, I mean, as humans, good lord, we've been wrong far more times than we've been right. I mean, as a husband, I can tell you, that's true. And father, it's like a daily basis. But so what we did with milk thistle was we say, milk thistle is good for liver liver detox is there for milk thistle is good for detox. And that's not true. And that's fine. I mean, that logical progression of thought makes sense, but it's not how it pans out. So it's dose related. So, phase one. There's a lot of talk about phase one out there. Phase one are very basic, rudimentary biochemical processes. Oxidation reduction hydrolysis, if those suck in a person, detox is not your problem. They get highlighted a lot—phase one pathways. But in the end, people will say technically you need some B vitamins for this, but you need B vitamins to run most of the basic biochemical processes in the first place. So, honestly, phase one is not a phase I worry about too much in people. As long as they're nutrient sufficient, which basically means taking a good quality multi, they're probably—and I say big probably—they're probably fine with phase one. There are things incidentally, like some of those vegetables that you mentioned. So this is where it gets crazy. In high doses, things like celery or apples or carrots can inhibit phase one a little
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast ! I am Dr Radhika Vijay, if you are wondering what are the most broad and basic divisions of the subject Pharmacology, you will find it all in today's episode. Broadly, Pharmacology can be divided into Pharmacodynamics and Pharmacokinetics. Pharmacodynamics covers all details and lets us know ," What the drug does to the body?" On the other hand, Pharmacokinetics is the ADME study, it covers complete drug movement inside the body, telling about all the four processes in detail, Absorption, Distribution , Metabolism and Excretion. All in all, we get to know, "What body does to the drug?" With the help of two examples for each of these divisions, I will clearly describe the whole description and points. After telling you all about these broad pharmacological divisions, I will be throwing light on the Golden connection of Pharmaceutics, Pharmacokinetics, Pharmacodynamics and Pharmacotherapeutics. Its a chain connection step by step with a wonderful description so that you can memorize nicely and understand. fully. On this point of discussion, your query is definite to arise about other branches discussion which you know or you have. ever heard about. Well, no worries, with a promise to lighten up next school of thought with details about other branches, I will humbly depart today. For all updates and latest episodes, please visit www.ispharmacologydifficult.com. You can follow me on social media handles like twitter, insta, facebook and linkedin all with same names"Is Pharmacology Difficult". If you are listening for the first time, do follow me here on your favourite platform, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast ! I am Dr Radhika Vijay, if you are wondering what are the most broad and basic divisions of the subject Pharmacology, you will find it all in today's episode. Broadly, Pharmacology can be divided into Pharmacodynamics and Pharmacokinetics. Pharmacodynamics covers all details and lets us know ," What the drug does to the body?" On the other hand, Pharmacokinetics is the ADME study, it covers complete drug movement inside the body, telling about all the four processes in detail, Absorption, Distribution , Metabolism and Excretion. All in all, we get to know, "What body does to the drug?" With the help of two examples for each of these divisions, I will clearly describe the whole description and points. After telling you all about these broad pharmacological divisions, I will be throwing light on the Golden connection of Pharmaceutics, Pharmacokinetics, Pharmacodynamics and Pharmacotherapeutics. Its a chain connection step by step with a wonderful description so that you can memorize nicely and understand. fully. On this point of discussion, your query is definite to arise about other branches discussion which you know or you have. ever heard about. Well, no worries, with a promise to lighten up next school of thought with details about other branches, I will humbly depart today. For all updates and latest episodes, please visit www.ispharmacologydifficult.com. You can follow me on social media handles like twitter, insta, facebook and linkedin all with same names"Is Pharmacology Difficult". If you are listening for the first time, do follow me here on your favourite platform, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast ! I am Dr Radhika Vijay, if you are wondering what are the most broad and basic divisions of the subject Pharmacology, you will find it all in today's episode. Broadly, Pharmacology can be divided into Pharmacodynamics and Pharmacokinetics. Pharmacodynamics covers all details and lets us know ," What the drug does to the body?" On the other hand, Pharmacokinetics is the ADME study, it covers complete drug movement inside the body, telling about all the four processes in detail, Absorption, Distribution , Metabolism and Excretion. All in all, we get to know, "What body does to the drug?" With the help of two examples for each of these divisions, I will clearly describe the whole description and points. After telling you all about these broad pharmacological divisions, I will be throwing light on the Golden connection of Pharmaceutics, Pharmacokinetics, Pharmacodynamics and Pharmacotherapeutics. Its a chain connection step by step with a wonderful description so that you can memorize nicely and understand. fully. On this point of discussion, your query is definite to arise about other branches discussion which you know or you have. ever heard about. Well, no worries, with a promise to lighten up next school of thought with details about other branches, I will humbly depart today. For all updates and latest episodes, please visit www.ispharmacologydifficult.com. You can follow me on social media handles like twitter, insta, facebook and linkedin all with same names"Is Pharmacology Difficult". If you are listening for the first time, do follow me here on your favourite platform, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!
On today’s episode, Erica sits down with Daniel Turk who is a Board Certified Integrative Health Practitioner and Health Advocate. He is the moderator for the IHPC Institute where he provides ongoing Q&A Support for others in his field, and also runs his own virtual practice helping people across the US through sub-clinical lab testing and a variety of programs to help them overcome chronic conditions to achieve their health goals.In this episode, we’ll cover things like toxic burden, what a functional medicine detox is and who might benefit from doing one. You’ll also learn how to tell whether a protocol you’re doing is a true functional medicine detox or not.We’ll also share some hacks and tips for making your first detox as painless as possible and how to continue supporting your body’s ability to detox in everyday life.Please note that nothing shared in this episode is medical advice. Check with a qualified health practitioner on whether or not detox would be a good idea for you.Join Erica’s Facebook group:https://www.facebook.com/groups/1787216871446982/Link to the detox protocol that Erica uses:https://equi.life/products/dr-cabral-detox?irad=909135&irmp=2518171Resources and studies mentioned during the episode:Modulation of Metabolic Detoxification Pathways Using Foods and Food-Derived Componentshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488002/ TSCA Chemical Substance Inventoryhttps://www.epa.gov/tsca-inventory/how-access-tsca-inventory EWG Clean 15/ Dirty Dozenhttps://www.ewg.org/foodnews/ Excretion of Toxic Elements in Sweathttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312275/ The 10 American Study by The Environmental Working Group (video)https://www.ewg.org/news/videos/10-americansFollow DanielIG: @my_bio_wellnessFollow Erica:Instagram: @ericaalisonwellnessWebsite: www.ericaalisonwellness.comFollow Lauren:Instagram @laurengerminarioFacebook @buildabiglifeWebsite: www.buildabiglife.comFollow the podcast Instagram @theresahackforthat
Will van der Hart - Living The Vital Life: Excretion by Podcasts from St Dionis Parsons Green
The Slamcasters celebrate their 2nd year of excellence by reviews crappy WWE television, making predictions for Clash of Champions, discussing NJPW's G1 Cup, AEW, and much more. #comegetslammedWe are in the process of creating LIVE interactive programming. To be notified when LIVE shows are launched and for the opportunity to speak to us on-air, JOIN our Discord Channel: https://discord.gg/CBrgysEToday is a great day to start your own podcast. Whether your looking for a new marketing channel, have a message you want to share with the world, or just think it would be fun to have your own talk show...podcasting is an easy, inexpensive, and fun way to expand your reach online.Create your podcast using the Buzzsprout platform. Receive a $20 Amazon gift card after a 2 month paid subscription: https://www.buzzsprout.com/?referrer_id=160166Our YouTube EXCLUSIVE Darkside of Ring critique is over, but you can still listen to the entire playlist. Go give the episodes a listen. Be sure to SUBSCRIBE and HIT THAT BELL at this link: https://bit.ly/2IMEYUw so you don't miss any YouTube updates.Saturday Night SlamCasters is looking to begin interviewing rising stars in professional wrestling. If you, or anyone you know, may be interested in being interviewed by the crew, please contact us @saturdaynightslamcasters@gmail.comPlease subscribe and share on social media (YouTube, Facebook, and Twitter).YouTube: https://bit.ly/2IMEYUwFB: https://www.facebook.com/SlamCasters/Twitter: https://twitter.com/slamcasters#ComeGetSlammedConnect with us:"The Natural" Chris Black -TWITTER: https://twitter.com/the_natural_CBIG: @thenaturalchrisblackMondo Lucha HOF Xavier Mustafa -TWITTER: https://twitter.com/XavierMustafaTru Element 78TWITTER: https://twitter.com/SlamcasterTE78
This episode reviews the topic of Excretion including: The key excretion organs of plants and animals. The structure and function of the kidney and the role of ADH in Osmoregulation. This episode is suitable for all examination boards but more specifically geared to IGCSE Edexcel.
Dr. Scott was a lifelong athlete who battled lots of illness and pain. These experiences led him to Athletic Training and eventually on to become a Doctor of Chiropractic. After battling multiple health issues including Mold poisoning and Lyme Disease and healing himself of these naturally Dr. Scott now exclusively works with those whose lives have been affected by Toxins and Toxicity. He addresses many things in his practice but understands and incorporates principles stating that all areas of life must be evaluated for someone to heal. The human body is energy and chemicals! Nowadays Detox is more important that nutrition! Based off studies in 2015 concerning placental blood in the cord the likeliness of every human being toxic is 100% simply from heavy metals from mom and pesticides etc. These toxins can wreak health havoc from birth and show up later in life in the form of symptoms. Toxins especially love fat and nerves, so they bury themselves in the brain and fatty areas of the cells. One growing area is glyphosate or Round Up being found in soft tissue injuries. Pesticides destroying our bodies. Role of Cellular Healing Each cell has an outer membrane made up of 2 layers of fat Toxins bind to the receptors meant for healthy chemicals and cause congestion and cellular inflammation. Inside each cell has organs which also have layers of fat making up their membranes One specific organ is the mitochondria or energy center and needs to be addressed when handling toxin removal. The process of toxin removal is not one size fits all but in general the order is necessary. Remove Toxins Must heal outer cell membranes by eating lots of healthy fats (grass-fed butter, olive oil, coconut oil, avocado oil, www.SCTOIL.com) which will open channels to the inside of the cell Raise Cellular Energy Inside will also benefit from healthy fats but now also adding Selenium, Iodine, Minerals, and Oxygen will help the cells begin to dump toxins out of the cell into the organs of Excretion like the Liver and Gall Bladder and Kidneys and Skin. Get the Toxins out (super important and often left out as toxins will rebind) Coffee enemas and palmitic acid in the coffee force the liver and gall bladder to cleanse and dump so it can bind the toxins in the bile duct and get it in the toilet before they reabsorb into the body. Hydration is a must so the kidneys can process and get rid of toxins. Castor Oil packs are amazing ways of assisting the organs Movement to stimulate Lymphatic System. Rebounding, walking, stretching all get the lymphs to move and help drain. Great nutrition helps the gut health for this process. A typical cleanse is not a detoxification as it likely will only clean outside the cell and not the inside and may likely increase reactions and cause more long-term illness. Again, the order is very important, and each stage is managed and has its own protocols. Dr. Scott 5 recommendations for those in Chronic Pain Bedtime Routine is a must including stretching before bed Lemon Water assists the Kidneys in filtration and binding of toxins Tablespoon or more of Himalayan Sea Salt daily to stimulate the sodium/potassium pump. Sleep Coffee Enemas to get the cleaning going. Find Dr. Richmond here www.thrivehealthcenters.com Contact him there for a free 30-minute discovery call to see if working with him on chronic pain and detox removal is what you need!
ADME testing (Absorption, Distribution, Metabolism and Excretion) is an essential part of early stage drug development. In this episode, Dr. Matt Hutzler, Director of ADME Services at Q2 Solutions, describes the common paradigm of ADME testing and why short turnaround times are important. Because speed is so important, outsourcing testing overseas may not make as much economic sense as it might have in the past, given shipping costs and the possibilities for delays (at customs for example.) Dr. Hutzler explains the factors that contribute to the success of high-throughput ADME testing and what advances and innovations we might expect in the future.
MedFlashGo | 4 Minutes Or Less Daily Rapid Review Of USMLE, COMLEX, And Shelf For Medical Students
Welcome To The MedFlashGo Podcast. This Is Your Daily 4 Minutes Or Less Rapid Review for medical students. Topics are based on medical board examinations including USMLE, COMLEX, And Shelf Exams. We release a new episode every weekday! In this question of the day, Sean asks students to identify the correct value for FeNa in certain renal conditions. These questions are powered by MedFlashGo The First Voice-based interactive medical question bank currently available on Alexa. This tool allows medical students to study medical topics and be interactively tested without the use of a screen. You can study on your couch, in your car, and on the move without the use of a screen. To get access to the free audio-interactive question bank, click here or go to your Alexa application and search medflashgo In the skills section. To learn more details go to medflashgo.com and check out our frequently asked questions section. Please know that these questions were creatively designed by medical students and physicians for the purpose of education and do not replace health information given from your health professionals. We have tried our best to make sure the information is accurate please, so please let us know if you find any errors and we will be sure to correct them. --- Send in a voice message: https://anchor.fm/medflashgo/message
In the adventure the party journeys underground to the heart of the Isle of Storms in the first dungeon of this D&D campaign. It only took 11 episodes to get here. Nailed it. In the intermission, we share some recommendations of content in the RPG space from Black creators, who are very underrepresented in this hobby.
According to Mayoclinic.org, “gout is a common and complex form of arthritis that can affect anyone. It's characterized by sudden, severe attacks of pain, swelling, redness and tenderness in the joints - often the joint at the base of the big toe. An attack of gout can occur suddenly, often waking you up in the middle of the night, with the sensation that your big toe is on fire. The affected joint is hot, swollen, and so tender that even the weight of the sheet on it may seem intolerable.”Research – Combined Supplementation with Glycine and Tryptophan Reduces Purine Induced Serum Uric Acid Elevation by Accelerating Urinary Uric Acid Excretion – which appeared in the November 2019, online journal Nutrients, states that, “the progression of gout is suggested to result from an imbalance between uric acid synthesis and excretion. The most important factor considered to increase the risk of gout is hyperuricemia with persistently high serum uric acid levels. In particular, hyperuricemia has been suggested to be caused primarily by weakened kidney excretion of uric acid.”Investigators from Japan used a randomized, single-blind, placebo-controlled, crossover clinical trial designed to examine whether combined supplementation with glycine and tryptophan (amino acids) suppressed the elevation in serum uric acid levels - caused by purine (like liver and other organ meats, anchovies, chocolate) ingestion, and accelerated urinary uric acid excretion in subjects with lower urate excretion.Glycine, a non-essential amino acid, enhances the urinary excretion of uric acid in healthy individuals, in addition to those people with gout in prior studies. Tryptophan’s (an essential amino acid) effect on lowering uric acid levels is somewhat suspect at this point, which was why the Japanese investigators sought to confirm whether or not the combined effect of both amino acids would synergistically lower uric acid.The study group included healthy Japanese males aged 20–64 years, with lower urinary uric acid excretion, and no prior history of liver, renal, heart, or severe disease, drug or food allergy, or routine use of drug or dietary supplements for hyperuricemia.”According to the researchers, “all volunteers ingested four test drinks (A; placebo, B; tryptophan, C; glycine, or D; glycine + tryptophan) in the crossover design,” with a small amount of lemon flavor and critic acid added to achieve a standardized taste.The volunteers maintained their daily eating and drinking schedule – refraining from eating and drinking alcohol, for at minimum, 10 hours before the experiment. After an overnight fast, 200 milliliters were consumed, followed by voiding urine. Blood was collected 1 and 2 hours after the experimental drink was consumed.The study concluded that, “the combined supplementation with glycine and tryptophan significantly reduced the elevation in serum uric acid levels induced by purine ingestion via the acceleration of uric acid excretion and urate clearance in healthy males with lower urate excretion.”It was also determined that, “tryptophan alone did not induce serum uric acid elevation or urinary excretion of uric acid, but it might have enhanced the action of glycine by regulating the metabolism of glycine to creatinine.”Before you consider treating yourself, if applicable, you must first consult with your personal physician for guidance.
SUBJECTIVEIn episode 4, we ask the important questions about the Aquaman cinematic universe (and also spend a not insignificant amount of time thirsting after Jason Momoa).(I mean, look at him.)Anyway. What is up with the physiological class stratification of Atlanteans? Is blonde hair a curse? Why is Pinocchio so important to this movie? AND WHY WON'T ANYONE TALK ABOUT THE DINOSAURS??? We answer none of these questions and answer a bunch of other ones in this ep!OBJECTIVEResources, Citations, and Mentions:How Fish Gills Work, Today I Found Out, Sep 2011The Multifunctional Fish Gill: Dominant Site of Gas Exchange, Osmoregulation, Acid-Base Regulation, and Excretion of Nitrogenous Waste - David H. Evans, Peter M. Piermarini, and Keith P. Choe; Physiological Reviews, Vol 85, Issue 1, Jan 2005Pulmonary ventilation–perfusion mismatch: a novel hypothesis for how diving vertebrates may avoid the bends - Daniel Garcia Párraga, Michael Moore and Andreas Fahlman; Proceedings of the Royal Society B, Volume 285, Issue 1877, April 2018Do Whales Suffer From Decompression Sickness? by Sara Mynott, Nature: Saltwater Science, May 2013The breathing response of whales and other marine mammals is also triggered by carbon dioxide, but not until much higher levels than in people. — How do Whales and Dolphins Sleep Without Drowning? in Scientific American, Feb 1998Karathen is, in fact, Julie Andrews!The Depths Below - Ring of Fire, NOAAUndersea Volcano Eruptions Caught On Video, Discovery YouTube channelCorrections:Some sources say to NOT vent fish. Some sources say to do it. So... we don't know.Venting: A Guide to Releasing Reef Fish with Ruptured Swimbladders, Florida Sea GrantRockfish Barotrauma Information, California Department of Fish and WildlifeASSESSMENTDeepa: 7 out of 10 invisible chest gillsJen: 3 out of 5 crab people for narrative coherence, 5 out of 5 Khal Drogos for Jason MomoaOverall DC cinematic universe scale 15 out of 10 (only outpaced by Wonder Woman which is at 2000 out of 10)PLANSpecial thanks to Butterscotch Shenanigans for letting us use their podcast equipment! Check out their game dev comedy podcast Coffee with Butterscotch!Subscribe to our medical ramblings on Apple Podcasts, Spotify, Stitcher, or wherever you get your podcasts! Rate, review, and tell your friends!Got a question or suggestion? Find us on Twitter @DocsWatchPod, or visit us at docswatchpod.com.Theme Music and SFX: Kevin MacLeod (CC BY) - RetroFuture Clean, Danse Macabre-Big Hit 2
On poo, pooing and all that palaver. A children's author, a colorectal surgeon, a psychologist walked onto stage...
On poo, pooing and all that palaver. A children's author, a colorectal surgeon, a psychologist walked onto stage...
While Erin is away we have Chad draw out a review of Man×Koi Ero Manga de Hajimaru Koi no Plot. Talking Points: All about plot, Hentai details, Bear cave vagina, Cleavage foreshadowing, Thigh religion, Door spring penis, Quantity quality & thickness of cum, Hongry, Excretion power, Honest dick judge, Pusshy, Permanent Viagra, Deep character development, Phantom erection, Calamity Cock. Music by Snortrax
David A. Bluemke, MD, PhD, Editor of Radiology discusses five research articles from the February 2019 issue of Radiology. ARTICLES DISCUSSED – Summary of Radiomic versus Convolutional Neural Networks Analysis for Classification of Contrast-enhancing Lesions at Multiparametric Breast MRI. Radiology 2019; 290:290-297. Summary of Detection of Breast Cancer with Mammography: Effect of an Artificial Intelligence Support System. Radiology 2019; 290:305-314. Summary of Validity of RECIST Version 1.1 for Response Assessment in Metastatic Cancer: A Prospective, Multireader Study. Radiology 2019; 290:349-356. Summary of Long-term Excretion of Gadolinium-based Contrast Agents: Linear versus Macrocyclic Agents in an Experimental Rat Model. Radiology 2019;290:340-348. Summary of Detection of Colorectal Hepatic Metastases Is Superior at Standard Radiation Dose CT versus Reduced Dose CT. Radiology 2019;290:400-409.
An 18-year-old female athlete reports easy fatiguability and weakness
In the talk we touched the surface on a number of topics including: - Reasons behind what made him decide to write about the Psychology in the Bathroom? - The psychology of excretion and disgust. And why there is so much taboo surrounding the gut? - We also talked about the anal character with the earliest discussion going as far back Freud and psychoanalysis. - How earlier anal traits or definitions correlate with more recent psychological condition, like OCD, Perfectionism, Orderliness, Authoritarianism, & Type A personality. - We touched on the nature of swearing and the origins of scatological swearing & why some people offended by it, and cultural and gender differences - We also talked about flatulence and emotion, defensive flatulence and enjoyment of flatulence, and gender differences. - We also talked about Toilet Graffiti and the theories of Latrinalia including the differences between genders. And finally we talked about the great debate surrounding whether the toilet seat should be left down. This talk was only a taste or smell ? of the interesting information covered in this book and I encourage everyone to grab a copy and have a read. I hope you enjoy the conversation
This episode, We talk about Saul's childhood masterbating habits; Saul does mushrooms for the first time; and Nick finally uses his new lawnmower. In Current Events we discuss the Youtube HQ shooting. And, Danell reads the funniest Amazon review ever posted. Enjoy! Follow us: Twitter - @JMOpodcast, @NickLarson85, @BabyManChild Instagram - @JMOpodcast, @NickLarsonComedy, @ElComicoSaul Snapchat - @Nicklarson85, @Truheo84 Visit our website - http://www.jokemeoff.net/
This podcast covers the kidney, nephron, the skin and muscles as part of a biology review for the MCAT
God commands us to get rid of sin in our lives, and He gives us help to do it
God commands us to get rid of sin in our lives, and He gives us help to do it
Editor's Audio Summary by Phil B. Fontanarosa, MD, Executive Editor of JAMA, the Journal of the American Medical Association, for the May 24, 2016 issue
Get a 2-meal discount from Blue Apron here: http://cook.ba/1W7fRdC The Survey Results: http://bit.ly/29boaUB If you liked this week’s video, we think you might also like this blog post about asparagus pee: http://bit.ly/1TOEBHZ FYI: We try to leave jargon out of our videos, but if you want to learn more about this topic, here are some handy keywords to get your googling started: Asparagus: a delicious, edible plant Odor: a smell, aroma Gas chromatography: a scientific technique used to separate and analyze compounds Sulfur: a yellow chemical element with the symbol S Asparagusic Acid: a sulfur containing compound present in asparagus People featured in this video: - Marcel Proust - Benjamin Franklin - John Arbuthnot ___________________________________________ Thanks to our supporters on https://www.patreon.com/MinuteEarth : - Today I Found Out - Maarten Bremer - Jeff Straathof - Mark Roth - Tony Fadell - Muhammad Shifaz - 靛蓝字幕组 - Jagdtiger - Alberto Bortoni - Valentin - Nicholas Buckendorf - Antoine Coeur ___________________________________________ Credits (and Twitter handles): Script Writer: Rachel Becker (@RA_Becks) Script Editor: Kate Yoshida (@KateYoshida) Video Illustrator: Ever Salazar (@eversalazar) Video Director: Emily Elert (@eelert) Video Narrator: Kate Yoshida (@KateYoshida) With Contributions From: Henry Reich, Alex Reich, Omkar Bhagat, Peter Reich, David Goldenberg Music by: Nathaniel Schroeder: http://www.soundcloud.com/drschroeder Image Credits: Purple, white and green asparagus - iStock.com/PicturePartners Viceroy Butterfly - Wikimedia user PiccoloNamek https://commons.wikimedia.org/wiki/File:Viceroy_Butterfly.jpg Eggs and Asparagus - Michelle Hooton (used with permission) https://www.flickr.com/photos/_hoot/8636916522 _________________________________________ Like our videos? Subscribe to MinuteEarth on YouTube: http://goo.gl/EpIDGd Get early, exclusive access to our videos on Vessel: https://goo.gl/hgD1iJ Support us on Patreon: https://goo.gl/ZVgLQZ Also, say hello on: Facebook: http://goo.gl/FpAvo6 Twitter: http://goo.gl/Y1aWVC And find us on itunes: https://goo.gl/sfwS6n ___________________________________________ References: Eriksson, N., Macpherson, J. M., Tung, J. Y., Hon, L. S., Naughton, B., Saxonov, S., . . . Mountain, J. (2010). Web-Based, Participant-Driven Studies Yield Novel Genetic Associations for Common Traits. PLoS Genetics PLoS Genet, 6(6). Retrieved from http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1000993 Mitchell, S. C. (2001). Food Idiosyncrasies: Beetroot and Asparagus. Drug Metabolism & Disposition, 29(4), 539-543. Retrieved from http://dmd.aspetjournals.org/content/29/4/539.full#ref-62 Mitchell, S. C., & Waring, R. H. (2014). Asparagusic acid. Phytochemistry, 97, 5-10. Retrieved from http://www.silae.it/files/Asparagusic acid.pdf Pelchat, M. L., Bykowski, C., Duke, F. F., & Reed, D. R. (2010). Excretion and Perception of a Characteristic Odor in Urine after Asparagus Ingestion: A Psychophysical and Genetic Study. Chemical Senses, 36(1), 9-17. Retrieved from http://chemse.oxfordjournals.org/content/early/2010/09/27/chemse.bjq081.full.pdf Waring, R. H., Mitchell, S. C., & Fenwick, G. R. (1987). The chemical nature of the urinary odour produced by man after asparagus ingestion. Xenobiotica, 17(11), 1363-1371. Retrieved from http://www.tandfonline.com/doi/abs/10.3109/00498258709047166
WHY YOU SHOULD LISTEN: None of us wants to see our kids get sick. Some would do anything to keep that from happening. But what REALLY happens when your child receives a vaccination? Today we’ll cover vaccine theory: the basics, some myths, and some facts that may change the way you think about vaccines and immunity. Listen in to hear the forbidden information kept from you by the medical community so that you can make a truly informed decision when it comes to vaccinations and what’s best for your child. WHAT YOU WILL HEAR: [00:00:55] Why this show must go on [00:06:40] Why do we get sick? The answer may surprise you! [00:08:10] Cell-mediated immunity: why it’s important that you be healthy enough to get sick [00:11:15] Proof of life = Excretion [00:13:45] GAPS and humoral immunity: how eating well may cure your cat allergy! [00:16:35] Immunity done right, the way Mother Nature intended [00:21:35] The basics of vaccine theory [00:24:35] Pasteur and Bechamp head-to-head: “Germ theory” vs. “Terrain theory.” [00:27:55] Inoculation: putting the cart before the horse [00:29:00] How do you convince the body to recognize a dead virus? The shocking truth about adjuvants that will change the way you think about vaccines [00:32:55] Forbidden stories to spur informed choice [00:38:00] The problem with “green” vaccines
We began discussing crepes and Rob overhearing a date. We got nostalgic for 976 and 900 numbers. Darren discussed his hate of seafood. We reviewed a preview for the new CBS reality show, The Briefcase. We discussed our question of the week, which was why don't you call in and that led to some tangential conversations. Ghost – Cirice Maruta – Genocide Interval Battlecross – Not Your Slave Listen to the Metal Injection Livecast on Stitcher or on iTunes (please leave a rating/review as well). Also, make sure to follow us on Facebook, Twitter and Youtube. Join us live next week starting at our new time 7pm Eastern (4PM Pacific Time) and going until 9PM eastern time for an all new edition of the Livecast. Our question of the week: "What should next week's question of the week be?" (and you better answer it yourself!) Leave a voicemail below with your answer and we may air it on next week's show:
The Bible does not just deal with healing the broken, but also with how to live a good life
Editor's Audio Summary by Howard Bauchner, MD, Editor in Chief of JAMA, the Journal of the American Medical Association, for the August 21, 2013 issue
Interview with Martin J. O'Donnell, MB, PhD, author of Urinary Sodium and Potassium Excretion and Risk of Cardiovascular Events
Background: It has not been investigated whether there are associations between urinary iodine (UI) excretion measurements some years apart, nor whether such an association remains after adjustment for nutritional habits. The aim of the present study was to investigate the relation between iodine-creatinine ratio (ICR) at two measuring points 5 years apart. Methods: Data from 2,659 individuals from the Study of Health in Pomerania were analyzed. Analysis of covariance and Poisson regressions were used to associate baseline with follow-up ICR. Results: Baseline ICR was associated with follow-up ICR. Particularly, baseline ICR >300 mu g/g was related to an ICR >300 mu g/g at follow-up (relative risk, RR: 2.20; p < 0.001). The association was stronger in males (RR: 2.64; p < 0.001) than in females (RR: 1.64; p = 0.007). In contrast, baseline ICR
International Stem Cell Corporation (OTCBB:ISCO (stem cellsAbsorption Systems to utilize ISCO's parthenogenetic stem cell-derived human corneal tissue to measure drug disposition, drug safety and drug-drug interactions. The collaboration between the companies is focused on using Absorption Systems' know how in creating in vitro assay systems to develop a superior method of testing drugs that will also reduce the use of laboratory animals currently necessary for such tests. In the past, researchers have grown corneal cells in the laboratory, but ISCO is believed to be the only company to grow a self-assembling corneal construct suitable for toxicity testing in the laboratory and possibly suitable for . ISCO's corneal constructs include cell layers and structures normally found in a human cornea, as confirmed by an independent third-party laboratory. ISCO's proprietary lines of parthenogenetic stem cells remove the need for fertilized embryos and in a therapeutic setting, minimize the threat of immune rejection. This breakthrough was published in the peer-reviewed journal Cloning & Stem Cells (Volume 9, Number 3; September 2007:432-449 and, Volume 10, Number 1; March 2008:11-24). "The combination of ISCO's skill in culturing human parthenogenetic and Absorption Systems' proficiency in performing tissue-based assays may provide a powerful and unique drug testing model for the pharmaceutical industry and the field of ," commented Jeffrey Janus, president of ISCO. "In addition, this work complements ISCO's effort to use its parthenogenetic stem cells to create cell transplant therapies for diseases of the eye. We plan to further develop our corneal tissue technology with a goal of routinely growing living human corneas for ultimate use in human corneal transplants." "ISCO's corneal construct, combined with Absorption Systems' expertise in assessing drug disposition, may provide pharmaceutical and ophthalmology researchers with new insight, without the need for ," said Patrick M. Dentinger, president and CEO of Absorption Systems. " yield the type of definitive data expected by the , so we believe that our combined products will be of great interest to researchers studying diseases of the eye." ABOUT INTERNATIONAL STEM CELL CORPORATION (ISCO.OB): International Stem Cell Corporation is a California biotechnology company focused on developing therapeutic and research products. ISCO's technology, Parthenogenesis, results in the creation of pluripotent human from unfertilized human eggs. ISCO scientists have created the first Parthenogenetic homozygous stem cell line (phSC-Hhom-4) that can be a source of therapeutic cells that will minimize immune rejection after transplantation into hundreds of millions of individuals of differing sexes, ages and racial groups. These advancements offer the potential to create the first true "" and address ethical issues by eliminating the need to use or destroy fertilized embryos. ISCO also produces and markets specialized cells and growth media worldwide for therapeutic research through its subsidiary Lifeline Cell Technology. For more information, visit the ISCO website at: www.internationalstemcell.com. To subscribe to receive ongoing corporate communications please click on the following link: http://www.b2i.us/irpass.asp?BzID=1468&to=ea&s=0. ABOUT ABSORPTION SYSTEMS: Founded in 1996 by Patrick Dentinger and Ismael J. Hidalgo, Ph.D., Absorption Systems, LP focuses on performing assays that can predict the Absorption, Distribution, Metabolism, and Excretion () of small molecules using a variety of in vitro, in situ, and in vivo biological models. Absorption Systems supports these assays with state-of–the-art bioanalytical capabilities and preclinical formulation services. For more information, visit: www.absorption.com FORWARD-LOOKING STATEMENTS: Statements pertaining to future financial and/or operating results, future growth in research, technology, clinical development and potential opportunities for the company and its subsidiary, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as "will," "believes," "plans," "anticipates," "expects," "estimates") should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the development and/or commercialization of potential products, uncertainty in the results of
Tierärztliche Fakultät - Digitale Hochschulschriften der LMU - Teil 03/07
A field study on lighting in the production of meat-type-chickens was conducted between April 2006 and February 2007. Part 1 comprised a survey on lighting practices in a substantial number of broiler farms in southern Germany (n = 187 broiler stables covering a total area of 276.337 m²). It was carried out on the basis of a questionnaire adapted to broiler management. The focus of data collection was put on animal welfare issues of lighting. It was found that in conventional broiler farming closed buildings, with or without windows, are the most common kind of facility used. This applies to the number of farms as well as to the total area. A comparatively high proportion of stables from the early days of poultry farming in Germany shows that these agricultural buildings often remain in use unchanged for decades. Thus, once taken, decisions on lighting have practical consequences over the whole life-cycle of an agricultural building. The surroundings in closed stables are primarily conceived to accommodate the need of farm staff for work-efficiency and workplace-safety. Scientific findings on visual perception of poultry have not been implemented systematically in poultry farming, yet even though lighting constitutes a central management factor which can influence behaviour and health of the animals to a substantial degree. An exception is the fact that conventional fluorescent lights with a flicker frequency of 100 Hz, which poultry may perceive as discontinuous, have largely been eliminated from the farms we examined. Subsequently the lighting environments of characteristic types of broiler sheds were examined by means of spectrophotometry. Data were collected on illuminance, irradiance, UVA-irradiance and colour temperature in summer as well as in winter. Substantial differences were found between the two sampling dates, particularly where ultraviolet radiation was concerned. Additionally considerable differences between the type of building (with or without daylight) could be described. Taking into consideration the enlarged sensory facilities of birds (perception of ultraviolet radiation, flicker fusion frequency higher than 100 Hz), it can be concluded that the currently used methods for sampling light intensity, particularly the lux-unit, are suitable for poultry to a limited extent only. Part 2 was a study on the effects of two lighting programmes which differed exclusively in intensity (5 lx and 20 lx) from the 13th day of the fattening period. The following parameters were collected and evaluated under field conditions: ► Development of intraocular pressure ► Development of eye measures ► Behaviour and time-budget ► Excretion of glucocorticoids (corticosterone) ► Performance parameters Under 5 lx a modulation of intraocular pressure was observed. Moreover all eye measures were larger under 5 lx than under 20 lx. A biological relevance of these differences, which were very slight, can be denied with a high certainty. The animals kept under 20 lx showed phases of higher activity and more explorative and comfort behaviour than the group raised under 5 lx. These results could be interpreted as a decrease in global activity due to the low light intensity. The lighting programme with an intensity of 5 lx resulted in a tendency for a higher excretion of fecal corticosterone, which was significant on day 35 only. This could be interpreted as a direct influence of dark surroundings on glucocorticoid metabolism. Bright lighting (20 lx) increased the risk for necrotic dermatitis (inflammatory process) by a factor of more than three. A prolonged fattening time of 37-39 days predisposed the animals to the development of necrotic dermatitis as well. Pododermatitis score was better under dim lighting. Further effects of lighting on production parameters could not be found. Taken together, these results give strong hints that a decrease of light intensity to approximately 5 lx at the beginning of the third week of a production cycle may constitute a tool to improve performance and prevent skin damage. Nonetheless these low light intensities could be stressful for the animals. These results were collected under field conditions and under certain restrictions. More research under controlled conditions remains therefore to be done.
Tierärztliche Fakultät - Digitale Hochschulschriften der LMU - Teil 03/07
Influence of repetitive duodenal application of activated charcoal on the elimination of the elimination of intravenously applied acetaminophen (N-Acetyl-para-aminophenol) The influence of the repeated administration of activated charcoal on elimination of intravenously injected acetaminophen was investigated in an in-vivo model of anaesthetized rats. 40 rats were randomized and divided into four groups of 10 animals, respectively. Concentration of 14C-marked acetaminophen and its metabolites was measured in plasma, urine and small intestine irrigation samples of all animals. To measure the influence of activated charcoal on elimination of acetaminophen, the small intestine of one half of the animals (n=20) was perfused with activated charcoal dissolved in polyethylene glycol (PEG) (= gastrointestinal dialysis), the small intestine of the other half (n=20) was perfused just with PEG. In order to answer the question whether activated charcoal interrupts enterohepatic circulation, half of the rats treated with activated charcoal and half of the PEG-treated animals (n=10, respectively) were subject to bile duct cannulation; the externalized bile was then quantified for acetaminophen. During a testing period of 3.5 hours, in the ileal effluent of animals with physiological bile flow, we detected ca. 20% of the dose administered originally; in the animals subject to cannulation, we found about 7%. 13% of acetaminophen and metabolites were found in the externalized bile. Activated charcoal did not influence the exsorption of acetaminophen into the small intestine. Terminal half-life in blood ranged from 35-51 minutes, there was no statistically significant difference between the groups (P=0.152). Neither did the Area under curve (AUC) – ranging from 2.6 to 3.3 g/min./l. – show significant variation between groups (P=0.392). Concentration of acetaminophen in liver and kidney samples, which were removed post mortem, was very low, ranging from 0.02 to 0.6% of the dose originally administered. Excretion of acetaminophen into urine varied widely (31-56%), correlating with diuresis. The absence of an effect of activated charcoal on elimination of acetaminophen and metabolites may have been caused by exsorption of insufficient amounts into the intestinal lumen.
Bisphenol-A-glycidyldimethacrylate (BisGMA) is used in many resin-based dental materials. It was shown in vitro that BisGMA was released into the adjacent biophase from such materials during the first days after placement. In this study, the uptake, distribution, and excretion of [14C]BisGMA applied via gastric and intravenous administration (at dose levels well above those encountered in dental care) were examined in vivo in guinea pigs to test the hypothesis that BisGMA reaches cytotoxic levels in mammalian tissues. [14C]BisGMA was taken up rapidly from the stomach and intestine after gastric administration and was widely distributed in the body following administration by each route. Most [14C] was excreted within one day as 14CO2. The peak equivalent BisGMA levels in guinea pig tissues examined were at least 1000-fold less than known toxic levels. The peak urine level in guinea pigs that received well in excess of the body-weightadjusted dose expected in humans was also below known toxic levels. The study therefore did not support the hypothesis.
Background: The number of inducible adhesion molecules known to be involved in cell-mediated allograft rejection is still increasing. In addition, recent data describe complement activation during acute humoral allograft rejection. The aim of this study was to assess whether specific molecules from either pathway are excreted into urine and whether they can provide useful diagnostic tools for the monitoring of renal transplant recipients. Methods: Urinary concentrations of soluble adhesion molecules (sICAM-1, sVCAM-1) and of the complement degradation product C4d were determined by standardized ELISA technique in 75 recipients of renal allografts and 29 healthy controls. Patient samples were assigned to four categories according to clinical criteria: group 1: acute steroid-sensitive rejection (ASSR, n=14), group 2: acute steroid-resistant rejection (ASRR, n=12), group 3: chronic allograft dysfunction (CAD, n=20) and group 4: stable graft function (SGF, n=29). Results: All patients with rejection episodes (groups 1-3) had significantly higher values of urinary sC4d compared with healthy controls and patients with stable graft function (p
Background/Methods: In Germany, iodine deficiency is common. In a representative group of 2,500 Germans (age >13 years), using a specially designed food questionnaire, the iodine intake was calculated. In addition, iodine and creatinine concentrations in spot urine samples were determined in three groups with a possibly increased risk of iodine deficiency (769 conscripts, 886 pairs of mothers and newborns) or future hyperthyroidism (574 adults, age range 50-70 years) from 26 representative regions. In four groups of controls (young and older male and female adults; n = 91), 24-hour urine iodine and creatinine were measured in six diurnal fractions to calculate group- and period-specific factors for the estimation of the 24-hour iodine excretion from data of iodine/creatinine ratio and time of micturition in spot urine samples. Results: The mean calculated iodine intake (excretion) was 119 mug/day for the group of Germans above 13 years; it was 119 mug/day (125 mug/day) for adults aged 50-70 years, 137 mug/day (125 mug/day)for conscripts, and 162 mug/day for breast-feeding mothers. The median iodine concentration (iodine/creatinine ratio) was 9.4 mug/dl (83 mug/g) in 566 adults aged 50-70 years, 8.3 mug/dl (57 mug/g) in 772 conscripts. and 5.6 mug/dl (156 mug/g) in 739 breast-fed newborns. Conclusions: Compared to older data, the iodine intake in Germany has increased. In 1996, the meticulously quantified average deficit was about 30% of the recommended iodine intake. Copyright (C) 2002 S. Karger AG, Basel.
The monomer triethyleneglycoldimethacrylate (TEGDMA) is used as a diluent in many resin-based dental materials. It was previously shown in vitro that TEGDMA was released into the adjacent biophase from such materials during the first days after placement. In this study, the uptake, distribution, and excretion of 14C-TEGDMA applied via gastric, intradermal, and intravenous administration at dose levels well above those encountered in dental care were examined in vivo in guinea pigs and mice as a test of the hypothesis that TEGDMA reaches cytotoxic levels in mammalian tissues. 14C-TEGDMA was taken up rapidly from the stomach and small intestine after gastric administration in both species and was widely distributed in the body following administration by each route. Most 14C was excreted within one day as 14 CO2. The peak equivalent TEGDMA levels in all mouse and guinea pig tissues examined were at least 1000-fold less than known toxic levels. The study therefore did not support the hypothesis.
A high prevalence of hepatitis C virus infection in porphyria cutanea tarda in some populations suggests a close link between viral hepatitis and alteration of porphyrin metabolism. Moreover, there is evidence of a role of porphyrinopathies in hepatocarcinogenesis. The aim of our study was to obtain data on the prevalence and patterns of heme metabolism alterations in patients with chronic hepatitis C virus infection. Urinary porphyrin excretion was prospectively studied in 100 consecutive outpatients with chronic hepatitis C infection without signs of photosensitivity, using an ion-pair high performance liquid chromatography method. Increased total porphyrin excretion was found in 41 patients, with predominant excretion of coproporphyrins (whole study group: mean 146 mu g/g creatinine, interquartile range 76-186; normal coproporphyrin, heptacarboxyporphyrin III increased) but the total porphyrin excretion was only slightly elevated in this case. In the whole group, total urinary porphyrin excretion correlated well with serum bilirubin and was inversely correlated with albumin and thrombin time. In conclusion, secondary coproporphyrinuria occurs frequently in heptatitis C infection, whereas in Germany, preclinical porphyria cutanea tarda seems to be rare in these patients.
To evaluate the clinical relevance of testing pituitary-ovarian responses in patients suffering from polycystic ovary syndrome (PCOS) with the GnRH agonist nafarelin, a 1.2-mg dose of nafarelin was given intranasally to 19 women with PCOS and 15 healthy premenopausal women. The subsequent analysis of steroids in both serum and urine during the test was carried out at several time points for up to 24 h. Serum levels of 17 alpha-hydroxyprogesterone were elevated at all time points of the test in PCOS patients vs. controls [at baseline, 3.5 +/- 0.2 vs. 1.8 +/- 0.1 nmol/L (P < 0.001); at 24 h, 9.9 +/- 0.9 vs. 4.9 +/- 0.3 nmol/L (P < 0.001)]. Basal levels of androstenedione were higher in the patient group, but there was no significant change during the test in either group. Serum testosterone levels were also found to differ in PCOS patients compared with the control values at baseline (2.2 +/- 0.2 vs. 1.5 +/- 0.1 nmol/L; P < 0.05) and after nafarelin treatment (at 24 h, 3.2 +/- 0.4 vs. 1.8 +/- 0.2 nmol/L; P < 0.05). Serum estradiol levels rose significantly in both groups during the test; the posttest levels were significantly higher in PCOS than in controls. The PCOS patients displayed a significant increase in androgen and gestagen metabolites as well as in glucocorticoid metabolites excreted in the urine during the 24 h. In the control subjects, except for 17 alpha-hydroxypregnanolone, which rose significantly, none of the urinary steroids investigated showed relevant changes during the nafarelin test. The posttest excretion of allo-tetrahydrocortisol (1.4 +/- 0.2 vs. 0.3 +/- 0.1 mumol/g creatinine; P < 0.001) and the increase in 17 alpha-hydroxypregnanolone excretion (1.4 +/- 0.2 vs. 0.3 +/- 0.1 mumol/g creatinine; P < 0.001) were distinctly higher in PCOS patients than in the controls; the diagnostic sensitivity of the combination of both parameters was 89% at a 93% specificity. Thus, measurements of 17 alpha-hydroxyprogesterone levels in serum and of urinary allo-tetrahydrocortisol and 17 alpha-hydroxypregnanolone after nafarelin treatment make this stimulation test a valuable diagnostic tool for identifying PCOS patients. The significant changes in the excretion of urinary androgen and gestagen metabolites, unmasked by GnRH agonist stimulation, suggest a functional alteration of the pituitary-ovarian axis. The reason for the increased excretion of glucocorticoid metabolites after nafarelin stimulation remains to be clarified.
Lithium treatment reduces the renal kallikrein excretion rate. Lithium salts are widely used agents for the prophylactic treatment of affective disorders. Lithium salts may be associated with distal nephron dysfunction. Kallikrein is a protease which is generated by the distal nephron. We used an amidolytic assay of chromatographically purified enzyme to determine the urinary excretion rate of active kallikrein in relation to lithium treatment. All plasma lithium concentrations were within the therapeutic range (0.4 to 0.9 mmol/liter). In 15 patients the urinary excretion rate of active kallikrein was 267.4 65.6 mU/24 hrs before lithium treatment, and fell to 117.8 39.6 mU/24 hrs (P < 0.05) on day 14 of lithium treatment. This reduction was associated with a decrease of immunoreactive kallikrein in the same urines by 66%. In another 15 patients who had undergone lithium therapy for an average period of 5.6 years, the urinary excretion rate of active kallikrein was 86.1 14.5 mU/24 hrs, while 21 age-matched healthy controls had an excretion rate of 364.1 58.4 mU/24 hrs (P < 0.05). Measurements of immunoreactive kallikrein in the same urine samples demonstrated a reduction of kallikrein after long-term lithium treatment by 78%. These observations could not be attributed to changes in creatinine clearance, renal sodium or potassium excretion rates or plasma concentrations of aldosterone and vasopressin. Addition of lithium to the urine in vitro had no demonstrable effect on kallikrein measurement by amidolytic assay. We conclude that lithium in therapeutic plasma concentrations may directly suppress the secretion of kallikrein by renal connecting tubule cells.
Tue, 1 Jan 1985 12:00:00 +0100 https://epub.ub.uni-muenchen.de/8524/1/8524.pdf Scriba, Peter Christian; Wood, W. G.; Friedrich, H. J.; Stubbe, P.; Hasenpunsch, U.; Smolarek, H.; Gutekunst, R.
Sun, 1 Jan 1984 12:00:00 +0100 https://epub.ub.uni-muenchen.de/7258/1/7258.pdf Bonjour, Jean-Pierre; Berlit, Peter; Kochen, W.; Krause, Klaus-Henning
Urinary excretion of nonesterified (NEC) and total cholesterol (TC) has been investigated in 79 patients with prostatic adenoma (BPH) and 48 patients with carcinoma of the prostate. Normal range of NEC was determined in 62 healthy individuals and was found to be 0.26-2.2 mg/24 hours (2 SD) with a mean value of 0.76 mg/24 hours. TC ranged from 0.3-2.9 mg/24 hours with a mean value of 0.92 mg/24 hours. In benign prostatic hyperplasia normal values for NEC and TC were determined in stages without residual urine. In contrast patients with BPH and residual urine showed elevated NEC in 42.1% and elevated TC in 61.4%. In prostatic carcinoma NEC hyperexcretion was present in 44.8% of stage A and B and in 52.6% of stage C and D. TC was elevated in 52.2% and 63.2%, respectively. Simultaneous determination of NEC and serum acid phosphatase (SAP) gave a pathologic result of at least one parameter in 51.7% of stage A and B and in 84.2% of stage C and D. If TC and serum acid phosphatase were combined, percentage of elevated values increases to 62.1 of stage A and B and was identical with 84.2 of stage C and D. If BPH with residual urine and other known conditions of urinary cholesterol hyperexcretion in males, pluripotential malignant testicular neoplasms and diseases of kidney and urinary tract, can be excluded with reasonable certainty, both parameters may be of value in diagnosis of prostatic cancer in even early clinical stages of the disease, especially in combination with the determination of SAP.
Mon, 1 Jan 1979 12:00:00 +0100 https://epub.ub.uni-muenchen.de/9254/1/9254.pdf Scriba, Peter Christian; Pickardt, C. R.; Habermann, J.
Sun, 1 Jan 1978 12:00:00 +0100 https://epub.ub.uni-muenchen.de/8289/1/8289.pdf Scriba, Peter Christian; Ulbrecht, G.; Gottsmann, M.; Erhardt, F.; Eversmann, T.; Habermann, J.
Sat, 1 Jan 1977 12:00:00 +0100 https://epub.ub.uni-muenchen.de/9247/1/9247.pdf Scriba, Peter Christian; Ulbrecht, G.; Eversmann, T.; Habermann, J. ddc:610, Medizin
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