Podcasts about ewing's sarcoma

Katie Kistner is the president of the Ryan Kistner Foundation, an organization devoted to increasing awareness of Ewing's Sarcoma.  She is also an executive secretary in the Hesperia Unified School District's personnel department.  

The cover for issue 40 of Oncotarget features Figure 5, "miR-210 silences the proapoptosis member CASP8AP2," by Kling, et al. which reported that hypoxic Ewing's sarcoma cells release exosomes that promote sphere formation, a stem-like phenotype, in EWS cells by enhancing survival. Analysis of the hypoxic exosomal miRNA cargo identified a HIF-1α regulated miRNA, miR-210, as a potential mediator of sphere formation in cells exposed to hypoxic exosomes. The knockdown of HIF-1α in hypoxic EWS cells led to decreased exosomal miR-210 levels and reduced the capacity of hypoxic exosomes to form spheres. Inhibition of miR-210 in hypoxic spheres attenuated sphere formation and overexpression of miR-210 in normoxic spheres significantly enhanced the number of EWS spheres. Together, the findings in this Oncotarget study suggest that hypoxic exosomes promote stemness in EWS cells by delivering enriched miR-210 that is capable of down-regulating apoptotic pathways, resulting in the survival of cells with increased sphere formation. Dr. Shantaram S. Joshi from The University of Nebraska Medical Center said, "Ewing's sarcoma (EWS) is an aggressive and highly malignant bone tumor that develops in children and adolescents." HIF -1α has been demonstrated to regulate tumor formation and stem cell survival in hypoxic cancer cells by inhibiting apoptosis. Emerging evidence indicates intercellular communication between tumor cells in hypoxic and normoxic regions contributes to functional differences associated with hypoxic tumors. Other reports demonstrated that shCD99 EWS-derived exosomes could transfer enriched miR-34a to recipient EWS cells and stimulate neural differentiation while in another study, EWS-derived exosomes carrying EZH2 mRNA could be delivered intact to mesenchymal stem cells. Studies in other cancer models investigating the role of hypoxic exosomes have provided insight into how hypoxic tumors can secrete exosomes that propagate an aggressive phenotype in cells outside the hypoxic niche. Exosomes released from hypoxic prostate cancer cells enhanced sphere formation in normoxic cells, but the authors were unable to elucidate a mechanism describing how hypoxic exosomes promote stemness in normoxic cells. The Joshi Research Team concluded in their Oncotarget Research Paper that this study describes a mechanism whereby EWS cells under hypoxic conditions release exosomes that enhance stemness in EWS cells. The authors identified a hypoxia regulated miRNA significantly expressed in hypoxic cells and HypoxicEXO and characterized a potential target that facilitates an apoptotic pathway critical to sphere formation. Ongoing studies are investigating the role of HIF-1α on regulating EWS stemness and together, the authors future aim is to investigate how HIF-1α selectively modulates the packaging of miRNAs into HypoxicEXO, and validate additional miRNAs that promote aggressive hypoxic phenotypes. Sign up for free Altmetric alerts about this article DOI - https://doi.org/10.18632/oncotarget.27702 Full text - https://www.oncotarget.com/article/27702/text/ Correspondence to - Shantaram S. Joshi - ssjoshi@unmc.edu Keywords - exosomes, hypoxia, Ewing's sarcoma, stemness, miR-210 About Oncotarget Oncotarget is a weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology. To learn more about Oncotarget, please visit https://www.oncotarget.com or connect with: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Oncotarget is published by Impact Journals, LLC please visit http://www.ImpactJournals.com or connect with @ImpactJrnls Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957x105

Understanding others perspectives is critical to thrive in this world. - Paul Long How does optimism move us towards strength?  This week, motivational speaker Paul Long discusses “What’s Good?!” Paul travels the world delivering high-content keynotes and training to Fortune 500 companies, government agencies and trade associations. Paul is the author of the F.U.N. work book, podcast host, and president of Noah’s Bandage Project.  In this episode, Dr. Robin and Paul discuss his acronym for F.U.N., inspiring story of pediatric cancer, and how to gravitate towards what gives us strength. About Paul Long Paul Long is a motivational speaker and consultant that has challenged the corporate landscape for over a decade. Paul has provided memorable experiences for countless engagements including workshops, trade shows, keynotes and more. Paul Long’s Fundamism philosophy can be defined as the fundamentals of a F.U.N. and optimistic lifestyle. Paul's offering provides tactical skills on how to gravitate more towards the things that give you strength, as opposed to the things that don’t. Doing so will provide you more FUN, joy and fulfillment in life. As the Kansas City Royals’ 2016 Fan of the Year as selected by Major League Baseball, his shenanigans have been featured in media outlets like ESPN, the Washington Post and even the Wall Street Journal! In 2014, his catsuit adventures led Paul to Noah Wilson, a seven year old boy diagnosed with a rare form of cancer called Ewing's Sarcoma. Motivated by Noah’s presence and love for life, he began his lifelong commitment to help find a cure for pediatric cancer through Noah’s Bandage Project. Join Dr. Michelle and Paul as they talk about: Paul’s first career in insurance and the evolution into FUNdamism How Paul is coping as in extrovert in Quarantine F.U.N. - Foundation, Understanding others perspectives, Next steps How to create joy, fun, and fulfillment for everyone in times of collective tension The importance of listening and learning about other’s perspectives, and how to be sincere when doing so Noah Wilson’s inspiring story of pediatric cancer Identifying opportunity gaps and how to close them Discover how we can be mindful with optimism as James shares: How to offer value during a time of isolation and radical change Times when it’s necessary to close the gate on people who don’t bring you strength The importance of awareness “When you’re aware, you’re halfway there” - Wendy Bash The mindset of being a victim vs. victor How you never want to be a rocking chair; moving a lot but never forward Listen and learn all about F.U.N with the acronym: Foundation Understanding Others Perspectives Next Steps “I am going to keep having fun every day I have left, because there is no other way of life. You just have to decide whether you’re a tigger or an Eyeore”- Randy Pausch Mentioned In This Episode Paul Long FUNdamism Noah’s Bandage Project Be Good To People Keith Haring Wendy Basch Episode on Small Changes Big Shifts Some Nights by Fun Randy Pausch Darrell Misak Connect Facebook Instagram Twitter YouTube LinkedIn Podcast

Becky is a lone parent, mum to two little monkeys and a widow. Two years ago she lost her husband Chris to a rare form of cancer Ewing's Sarcoma. She started this podcast in the hopes of not only opening up the conversation around bereavement, loss and grief. But in the hopes that it may help anyone who is currently feeling the way that she is. Becky talks openly about Chris, her life and how she has coped (and is still coping) after a monumental loss to her family. Her life is one filled with ups and downs, this time she is bringing you along for the journey. So sit back, get your brew in hand and prepare to talk about life...After. In Episode 6, Becky talks about the Covid-19 pandemic and how difficult a lock-down can be for people dealing with grief.

David Arthur, CEO, Salarius Pharmaceuticals explains the role of our epigenome and what happens when someone is suffering from an epigenetic illness such as Ewing's sarcoma.  A whole series of cancers can trace their cause back to the body misreading genes and that leads to dysregulation of genetic expression. With few options to treat Ewing's sarcoma, a rare orphan pediatric disease, Salarius is testing a new treatment that can provide hope to patients by inhibiting the LSD1 enzyme and effectively addressing the dysregulation. @salariuspharma #ewingsarcoma #ewingssarcoma #rarediseases Salariuspharma.com Listen to the podcast here  

David Arthur, CEO, Salarius Pharmaceuticals explains the role of our epigenome and what happens when someone is suffering from an epigenetic illness such as Ewing's sarcoma.  A whole series of cancers can trace their cause back to the body misreading genes and that leads to dysregulation of genetic expression. With few options to treat Ewing's sarcoma, a rare orphan pediatric disease, Salarius is testing a new treatment that can provide hope to patients by inhibiting the LSD1 enzyme and effectively addressing the dysregulation. @salariuspharma #ewingsarcoma #ewingssarcoma #rarediseases Salariuspharma.com Download the transcript here  

“Syndicate” is a group of individuals or organizations combined to promote some common interest. Our common interest at Rock Bottom Syndicate is to be of service.Rock Bottom Syndicate is my community of friends who, after having hit rock bottom, discovered that being of service to help others has a surprising side effect. We get better. We make better decisions. We learn to live strong, joyous lives.----------Rock Bottom Syndicate is about people who have a story to tell to inspire others to keep working toward their potential no matter what happens.Rock Bottom is an opportunity to learn, pivot and adapt to whatever life throws your way.Rock Bottom is a time where you can choose to take responsibility for everything in your life because when you take responsibility you gain control to change things for yourself.Your secrets are the prison of your emotions. Telling your story will set you free to be yourself, to heal, grow as a person and move on to enjoy the journey of a strong, joyous life.Ask for help. Tell your story.Reach out to Coach Joyce at @TotalWellCoach on all social media platforms. I love getting questions and DMs and making new connections! What do you need help with? What problem are you trying to solve! Your questions help me produce great content that helps more people!JOIN MY TOTAL WELL COACH INNER CIRCLE for virtual coaching, classes and webinars!Subscribe and share my TotalWellCoach YouTube Channel to see the video of our interview.If you love my work and want to support what I do, here’s a link to Make a Donation.

Becky is a lone parent, mum to two little monkeys and a widow. Two years ago she lost her husband Chris to a rare form of cancer Ewing's Sarcoma. She started this podcast in the hopes of not only opening up the conversation around bereavement, loss and grief. But in the hopes that it may help anyone who is currently feeling the way that she is. Becky talks openly about Chris, her life and how she has coped (and is still coping) after a monumental loss to her family. Her life is one filled with ups and downs, this time she is bringing you along for the journey. So sit back, get your brew in hand and prepare to talk about life...After. In Episode 5, Becky talks about new years resolutions, starting a new decade alone and how to focus on now and live in the moment.

Becky is a lone parent, mum to two little monkeys and a widow. Two years ago she lost her husband Chris to a rare form of cancer Ewing's Sarcoma. She started this podcast in the hopes of not only opening up the conversation around bereavement, loss and grief. But in the hopes that it may help anyone who is currently feeling the way that she is. Becky talks openly about Chris, her life and how she has coped (and is still coping) after a monumental loss to her family. Her life is one filled with ups and downs, this time she is bringing you along for the journey. So sit back, get your brew in hand and prepare to talk about life...After.     In Episode 4, Becky talks about the origins of the 'Vomit tree'. A special Christmas tradition started by the Cowley's to ensure the kids and Chris got their special piece of Christmas.

Becky is a lone parent, mum to two little monkeys and a widow. Two years ago she lost her husband Chris to a rare form of cancer Ewing's Sarcoma. She started this podcast in the hopes of not only opening up the conversation around bereavement, loss and grief. But in the hopes that it may help anyone who is currently feeling the way that she is. Becky talks openly about Chris, her life and how she has coped (and is still coping) after a monumental loss to her family. Her life is one filled with ups and downs, this time she is bringing you along for the journey. So sit back, get your brew in hand and prepare to talk about life...After.     In episode 3, Becky talks about Christmas Eve 2015, the day her husband Chris was diagnosed with Ewing's Sarcoma. She delves deep into Chris's diagnosis and their thoughts and feelings around all that happened.

Army-Navy Game, Malcolm Perry, Jamale Carothers, Keenan Reynolds, Joe Burrow, Heisman trophy, LSU, Liberty Bowl, Kansas State, Jalen Hurts, Justin Fields, Chase Young, Nebraska, Ohio State, Oklahoma, Clemson, O.J. Simpson, Eagles, Cowboys, Wentz, Pederson, Sanders, Scott,, Amari Cooper, Prescott, Bills, Steelers, Allen, McDermott, Texans, Titans, Flyers, Lindblom, Ewing's Sarcoma, Bears, Packers, Rodgers, Trubiskey, Rams, Goff, Everett, Patriots, Colts, Saints, Reich, Belichick, Kiffin, MartelliMark & Mark Talk Sports Radio Show is broadcast live at Monday's at 7PM ET on W4CY Radio (www.w4cy.com) part of Talk 4 Radio (www.talk4radio.com) on the Talk 4 Media Network (www.talk4media.com). This podcast is also available on Talk 4 Podcasting (www.talk4podcasting.com).

Kyle and Matt are BACK and the guys revel in the Sixers continued success as they improve to 14-0 at home and take down the Celtics in Boston as Joel Embiid silences the critics and goes OFF on those fellas in Boston. They also somehow get to talk about the Eagles being alive in the playoff hunt and still controlling their own destiny. Then they discuss the unfortunate news of Oskar Lindblom being diagnosed with Ewing's Sarcoma, a rare bone cancer. Then they wrap things up with the Phillies shopping the local FA market by signing Phil Gosselin & Matt Szczur! Follow Us! Twitter: @UndergroundPHI Kyle: @KBizzl311 Matt: @mattcastorina Watch LIVE: facebook.com/UndergroundSportsPHI Instagram: @undergroundphi Alyssa's Makeup Page: @MakeupByAlyssaAmber Twitch: twitch.tv/undergroundsportsPHI Merch & Apparel: dsgntree.com/underground-sports…hia?rq=Underground Intro Music: Arkells "People's Champ" Outro Music: Arkells "People's Champ"

News that we do not expect nor want to hear, the Flyers community was struck hard with Oskar Lindblom being diagnosed with Ewing's Sarcoma. We send our thoughts and prayers out to Oskar, his family, and the Flyers in this difficult process. We will also go over the past games against the Avalanche and the Minnesota Wild.

This week is our one year anniversary! They said it couldn't be done... or shouldn't, I can't really remember now... to celebrate, we cover some annoyed tennis people, an excited referee, people confused by sweets and a bloke serving dinner near some mud. We then cover off the mandatory football and cricket, as well as the exciting basketball, as well as playing everybody's favourite game. Then we hear about an unusual way to win a race.To donate to young Harry Shaw's foundation against Ewing's Sarcoma, here's the link: https://www.justgiving.com/fundraising/harrysgiantpledge.Support the show (https://www.patreon.com/backseatcoaches)

In this episode, we review multiple-choice questions related to the high-yield topics of Peripheral Nerve Injury & Repair and Ewing's Sarcoma. --- Send in a voice message: https://anchor.fm/orthobullets/message

In this episode, we review the high-yield topic of Ewing's Sarcoma from the Pathology section. --- Send in a voice message: https://anchor.fm/orthobullets/message

Melissa Smith is 17 years old and in grade 12. At the end of her grade 10 year she was diagnosed with Ewing's Sarcoma in her right leg, which is an aggressive bone cancer. She faced many complications and delays throughout her treatment, but is grateful she was able to keep her leg and is currently in remission. Despite her difficult year, Melissa continues to remain optimistic and to strive to bless the lives of others...

In this episode, you will hear first hand accounts from individuals that have battled their way through Ewing's Sarcoma.  Our website CancerSS.com has a special page dedicated to this episode, which is filled with inspiring videos of first hand accounts from Ewing's Sarcoma survivors. https://cancerss.com/2 Please take a second to hit the subscribe button to support our podcast and never miss a future episode.

Stephanie Zimmerman has been through a lot. Being diagnosed with Ewing's Sarcoma at a young age, she didn't quite understand how it could effect her in the long term. Later in life she needed a heart transplant because of her treatment as a child. Her story is powerful, and a testament to how the support of friends and family, and the uplifting thoughts written on note cards, can make a big difference.    Inspiration | Health | Wisdom | Ewing's Sarcoma | Heart Transplant

October 18, 2011 Host Dr. Tim Cripe and co-host Dr. Lionel Chow welcome special guest Dr. Jeff Toretsky on TWiPO to discuss his clinical and research interest in Ewing's sarcoma. Dr. Toretsky explains the challenges of developing a clinical grade drug from a small molecule for a specific target such as EWS-FLI1. The small market for a disease like Ewing's creates formidable hurdles for researchers, yet Dr. Toretsky is driven on by the question "If I don't do this, who will?" (17:54 mins) Dr. Jeff Toretsky is Professor of Oncology and Pediatrics at Georgetown University. He graduated with BS in Biochemistry from University of Wisconsin, Madison, WI, and recieved his MD from University of Minnesota, Minneapolis, MN. He completed fellowship training at the NCI Pediatric Branch. Please send any questions or comments to twipo@solvingkidscancer.org

By combining two drugs, researchers shrank tumors in some patients with treatment-resistant Ewing's sarcoma, a cancer that primarily affects the bones.