This Week in Pediatric Oncology

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This Week in Pediatric Oncology explores advances in childhood cancer with host Dr. Timothy Cripe from Nationwide Children\'s Hospital.

Solving Kids\' Cancer


    • Jan 14, 2025 LATEST EPISODE
    • infrequent NEW EPISODES
    • 33m AVG DURATION
    • 113 EPISODES


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    Latest episodes from This Week in Pediatric Oncology

    DFMO FDA Approval with Dr. Nicole Drezner

    Play Episode Listen Later Jan 14, 2025 35:23


    In this episode Dr. Timothy Cripe and Dr. Brenda Weigel are joined by FDA's Dr. Nicole Drezner, pediatric oncologist and the Deputy Division Director of the Division of Oncology 2 who led the FDA review and publication on the approval of DFMO. Listen in on the discussion surrounding the historic approval of DFMO, the first ever oncology drug approved in the setting to prevent relapse using an external control instead of randomization.

    New Focused Ultrasound Study for Progressive Diffuse Midline Glioma

    Play Episode Listen Later Mar 5, 2024 24:31


    Dr. Luca Szalontay,  Assistant Professor of Pediatrics at Columbia University Medical Center, discusses the work of Columbia's Initiative for Drug Delivery Innovation which is exploring new treatments for pediatric brain tumors utilizing Convection Enhanced Delivery and Focused Ultrasound. This initiative has launched a new clinical trial using Focused Ultrasound for patients with  progressive diffuse midline glioma (DMG)

    TWiPO #111: A Discussion on Oncofertility/Fertility Preservation with Dr. Seth Rotz

    Play Episode Listen Later Jun 15, 2023 26:55


    WATCH THE VIDEO WEBCAST HERE: https://youtu.be/ACFprGG10M0 In this episode, our host, Dr. Timothy Cripe from Nationwide Children's Hospital, is joined by Dr. Seth Rotz - pediatric hematologist/oncologist and the Director of the Fertility Preservation Program at the Cleveland Clinic in Cleveland, Ohio. Listen in as they discuss Dr. Rotz's career & specialty in fertility preservation for cancer patients: how he got into the field, what was needed to start the program, & the process and risks associated with oncofertility. ----more---- Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads. Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

    TWiPO #110: Discussing the ”Gift from a Child” Program with Al Gustafson & Dr. Angela Waanders

    Play Episode Listen Later Apr 26, 2023 33:48


    WATCH THE VIDEO WEBCAST HERE: https://youtu.be/jj3wJU0G7GI Listen in as our hosts, Dr. Tim Cripe & Dr. Brenda Weigel, are joined by Al Gustafson, from The Swifty Foundation, and Dr. Angela Waanders, from Lurie Children's Hospital of Chicago, to discuss the "Gift from a Child" program. This program is led by The Swifty Foundation & helps advocate and educate about post mortem pediatric brain tissue donations. Al & Dr. Waanders discuss the genesis of the program, what the program entails, as well as the benefits of tissue donations to empowering research. To learn more about "Gift from a Child", please visit: https://www.giftfromachild.org/ ----more---- Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads. Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

    TWiPO #109: Discussing the Early Detection of Cancer Using Genomics with Dr. Trevor Pugh

    Play Episode Listen Later Mar 29, 2023 27:33


    Listen in & join the TWiPO team in this special live recorded episode. Our host, Dr. Tim Cripe, along with his Nationwide Children's Hospital colleagues, Dr. Ryan Roberts, Dr. Elaine Mardis & Dr. Katherine Miller, are joined by Dr. Trevor Pugh, who is a clinical laboratory geneticist from the University of Toronto in Canada. Tune in as they all discuss Dr. Pugh's specialty in genomics & his recent work regarding the early identification of cancers in patients with Li Fraumeni Syndrome.  To learn more about this study, visit https://www.medrxiv.org/content/10.1101/2022.10.07.22280848v1.full.pdf ----more---- ----more---- Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads. Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

    TWiPO #108: Hepatoblastoma: A Physician & Patient Family's Story with Dr. Jim Geller & The Woolwines

    Play Episode Listen Later Feb 27, 2023 41:01


    WATCH THE VIDEO WEBCAST HERE: https://youtu.be/yyQ08ny_hDU Join our host, Dr. Timothy Cripe from Nationwide Children's Hospital, as he's joined with Dr. Jim Geller from Cincinnati Children's Hospital to discuss his expertise in pediatric liver cancer - hepatoblastoma. In this episode, we are also specially joined by Kelly & Jessica Woolwine as they tell their story of how they navigated the hepatoblastoma landscape to seek treatment for their daughter, Charlotte. ----more---- Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads. Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

    TWiPO #107: Discussing the International rEECur Trial for Ewing Sarcoma with Dr. Martin McCabe

    Play Episode Listen Later Feb 9, 2023 32:55


    WATCH THE VIDEO WEBCAST HERE: https://youtu.be/Z1D-7i4oy1s   Our host, Dr. Timothy Cripe from Nationwide Children's Hospital, is joined by Dr. Martin McCabe from the University of Manchester to discuss the results of the rEECur trial. The rEECur trial is an international randomized trial conducted on recurrent and primary refractory Ewing sarcoma patients. Dr. McCabe leads a discussion on the genesis of rEECur, what it entailed & what was learned from conducting this trial.   To learn more about this trial, please visit https://www.manchester.ac.uk/discover/news/study-identifies-best-treatment-for-rare-childhood-cancer/ ----more---- Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads. Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

    TWiPO #106: Genetic Predisposition in Childhood Cancer with Dr. Garrett Brodeur

    Play Episode Listen Later Jan 18, 2023 35:14


    WATCH THE VIDEO WEBCAST HERE: https://youtu.be/oR0KN5VFDVc Tune in as our host, Dr. Brenda Weigel from the University of Minnesota, is joined by Dr. Garrett Brodeur to discuss his expertise in genetic predispositions in childhood cancer. Dr. Brodeur is the Director of the Pediatric Cancer Predisposition Program at the Children's Hospital of Philadelphia (CHOP) - and listen in as he discusses his journey leading up to cancer predisposition, what the program entails, as well as the process of screening & surveillance protocols. To learn more about this program, please visit https://www.chop.edu/centers-programs/hereditary-cancer-predisposition-program ----more---- Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads. Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

    TWiPO #105: How to Build a Pediatric Cancer Disease Community with Ann Graham

    Play Episode Listen Later Jan 3, 2023 30:59


    WATCH THE VIDEO WEBCAST HERE: https://youtu.be/SvTprrL8wnY This Week in Pediatric Oncology #105 - January 3, 2023 Happy New Year from the TWiPO team! We are opening up this new year with an episode on building a pediatric cancer disease community. Our host, Dr. Timothy Cripe from Nationwide Children's Hospital, with special co-host, Donna Ludwinski from Solving Kids' Cancer, is joined by Ann Graham - Executive Director & Founder of MIB Agents. Listen in as they discuss Ann's personal cancer journey, how it spearheaded her own advocacy efforts, starting MIB Agents & their role in advocating within the childhood cancer research landscape. To learn more about MIB Agents, you can visit https://www.mibagents.org/ ----more---- Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads. Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

    TWiPO #104: PEEL Therapeutics - Nanotechnology for Pediatric Cancer with Dr. Joshua Schiffman

    Play Episode Listen Later Dec 13, 2022 29:10


    WATCH THE VIDEO WEBCAST HERE: https://youtu.be/41kwZNhrBBc This Week in Pediatric Oncology #104 - December 13, 2022 In this episode, Dr. Timothy Cripe & Dr. Brenda Weigel, are joined by Dr. Joshua Schiffman - CEO & Co-Founder of PEEL Therapeutics, Inc. Dr. Schiffman's own personal childhood cancer journey paved his way into the pediatric cancer field. Listen in as he discusses the formation of PEEL, their research work utilizing nanoparticles & nanotechnology, and the opportunities/challenges that are in PEEL's future. To learn more about PEEL Therapeutics, Inc, please visit https://peeltx.com/ ----more---- Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads. Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

    TWiPO #103: Focused Ultrasound Therapy for Pediatric Brain Tumors with Dr. Roger Packer

    Play Episode Listen Later Nov 30, 2022 31:02


    WATCH THE VIDEO WEBCAST HERE: https://youtu.be/SkyYLIZxQWA This Week in Pediatric Oncology #103 - November 30, 2022 Join us as our hosts, Dr. Timothy Cripe & Dr. Brenda Weigel, are joined by Dr. Roger Packer from Children's National Hospital in Washington DC. Dr. Packer is the Senior Vice President of the Center for Neurosciences and Behavioral Medicine at Children's National, which is introducing a low-intensity focused ultrasound (LIFU) therapy. Listen in as Dr. Packer discusses what LIFU is and the exciting new techniques and technologies behind it. To learn more, you can visit https://childrensnational.org/news-and-events/childrens-newsroom/2022/a-pediatric-brain-tumor-first-opening-the-blood-brain-barrier-to-deliver-targeted-therapies ----more---- Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads. Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

    TWiPO #102: Inequity in Pediatric Cancer Trials and Outcomes with Dr. Douglas Hawkins

    Play Episode Listen Later Nov 10, 2022 25:17


    WATCH THE VIDEO WEBCAST HERE: https://youtu.be/inNQc6x9Jy8 This Week in Pediatric Oncology #102 - November 10, 2022 Tune in as our hosts, Dr. Timothy Cripe & Dr. Brenda Weigel, are joined again by Dr. Douglas Hawkins - who is the current Chair of the Children's Oncology Group (COG). They discuss in depth the findings of a presented published paper regarding the inequities of childhood cancer outcomes based on external socioeconomic factors such as neighborhood and household poverty. To read the full paper, visit https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7936051&blobtype=pdf ----more---- Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads. Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

    TWiPO #101: An Update on the NCI Pediatric MATCH Trial with Dr. Will Parsons

    Play Episode Listen Later Oct 24, 2022 28:07


    WATCH THE VIDEO WEBCAST HERE: https://youtu.be/qVMiwnfVQZY Tune in as our hosts, Dr. Tim Cripe & Dr. Brenda Weigel, are joined by Dr. Will Parsons who is the Co-Director of the Brain Tumor Program at Texas Children's Hospital in Houston, TX. In this episode, Dr. Parsons discusses the background & purpose behind the NCI Pediatric MATCH Trial, the current status of the trial itself, and how the data can be used to benefit investigations moving forward. To learn more about the Pediatric MATCH Trial, you can go to https://childrensoncologygroup.org/pediatricmatch ----more---- Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads. Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

    This Week in Pediatric Oncology - 100th Episode

    Play Episode Listen Later Sep 30, 2022 36:01


    WATCH THE VIDEO WEBCAST HERE: https://youtu.be/8Lj3uFHWo60 Happy 100th Episode to the This Week in Pediatric Oncology Podcast! In this special milestone episode, our hosts, Dr. Timothy Cripe & Dr. Brenda Weigel, are joined by Scott Kennedy & Donna Ludwinski from Solving Kids' Cancer to reminisce on the history & creation of TWiPO and talk about their favorite podcast episodes from over the years. ----more---- Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads. Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

    TWiPO #99: Update on the Pediatric Cancer Data Commons and GEARBOx with Dr. Samuel Volchenboum

    Play Episode Listen Later Sep 7, 2022 29:50


    WATCH THE VIDEO WEBCAST HERE: https://youtu.be/bDbtses4w2E Tune in as our hosts, Dr. Timothy Cripe & Dr. Brenda Weigel, are joined by Dr. Samuel Volchenboum who is an Associate Professor of Pediatrics from the University of Chicago. Dr. Volchenboum spearheaded an international effort through two data platforms called the Pediatric Cancer Data Commons (PCDC) & GEARBOx (Genomic Eligibility Algorithm at Relapse for Better Outcomes). Listen in as he explains the importance behind these two platforms, as well as the challenges and barriers to data collaboration.   To learn more about the Pediatric Cancer Data Commons, you can visit http://commons.cri.uchicago.edu To learn more about GEARBOx, you can visit http://gearbox.pedscommons.org ----more---- Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads. Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

    TWiPO #98: Reflections on a Long, Distinguished Career & Future Perspectives with Dr. Jonathan Finlay

    Play Episode Listen Later Aug 22, 2022 30:20


    WATCH THE VIDEO WEBCAST HERE: https://youtu.be/FBgbCA6TZK4 Listen in as our host, Dr. Timothy Cripe, is joined by Dr. Jonathan Finlay to discuss his acclaimed & reputable career within the pediatric cancer landscape. Dr. Finlay reflects on his distinguished journey including how he got into pediatric immunology, how the field has evolved throughout his medical career, his views on exciting technologies & strategies, and how his personal experience as a patient influenced his position and mindset as a physician. Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads. Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

    TWiPO #97: GD2-CAR T Cell Therapy for H3K27M-mutated Diffuse Midline Gliomas with Dr. Robbie Majzner

    Play Episode Listen Later Jul 15, 2022 25:54


    WATCH THE VIDEO WEBCAST HERE: https://youtu.be/5TYFsjh91Tw Listen in as our host, Dr. Brenda Weigel from the University of Minnesota, is joined by Dr. Robbie Majzner - an Assistant Professor of Pediatrics in the Division of Hematology and Oncology at Stanford University's School of Medicine. Dr. Majzner goes into great detail about his recent clinical trial on GD2-CAR T cell therapy for H3K27M-mutated Diffuse Midline Gliomas - the findings, the process, and what the future holds. You can read more about Dr. Majzner's study here: https://www.nature.com/articles/s41586-022-04489-4 Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads. Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

    TWiPO #96: GPC2 Directed Immunotherapy for GPC2 Expressing Solid Tumors with Dr. Kristopher Bosse

    Play Episode Listen Later Apr 12, 2022 24:30


    WATCH THE VIDEO WEBCAST HERE: https://youtu.be/CEvlSC8dHeQ Listen in as our hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, are joined by Dr. Kristopher Bosse: an attending physician in the Division of Oncology at Children's Hospital of Philadelphia (CHOP). Dr. Bosse discusses his latest project that focuses on GPC2 Directed Immunotherapy, including what makes it a better target, the benefits & challenges of selecting new targets, as well as the strategy & applicability of the immunotherapy towards solid tumors.    Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads.

    TWiPO #95: Patient Advocates' Views in Neuroblastoma with Nick Bird & Donna Ludwinski

    Play Episode Listen Later Mar 11, 2022 33:35


    WATCH THE VIDEO WEBCAST HERE: https://youtu.be/rFd4Fwa_XVg Hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, are joined Solving Kids' Cancer's patient advocates, Nick Bird & Donna Ludwinski. Nick & Donna, along with other patient advocates, recently published a groundbreaking report, “When Innovation and Commercialization Collide: A Patient Advocate View in Neuroblastoma“. Listen in as they discuss the importance of advocacy and being the voice of cancer patients and their families, and how all stakeholders (i.e. academia, advocates, and big pharma) can collaborate and advance treatment options for pediatric cancer patients.   You can read their full paper here: https://ascopubs.org/doi/full/10.1200/JCO.21.01916?bid=123546590&cid=DM9111   Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads.

    TWiPO #94: Improved Outcome in Pediatric High-Risk Neuroblastoma with Dr. Wayne Furman

    Play Episode Listen Later Feb 16, 2022 34:24


    WATCH THE VIDEO WEBCAST HERE: https://youtu.be/Uf9UOGW3y-Q In this episode, our hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, are joined by Dr. Wayne Furman. Dr. Furman recently retired from the Department of Oncology at St. Jude Children's Research Hospital in Memphis, TN. Prior to his retirement, Dr. Furman had a paper published in the Journal of Clinical Oncology on his Phase II trial using hu14.18K322A in newly diagnosed high-risk neuroblastoma pediatric patients. Listen in as he discusses the results of this trial & the future of neuroblastoma treatments. You can read his full paper here: https://ascopubs.org/doi/abs/10.1200/JCO.21.01375?journalCode=jco Subscribe to TWIPO to get notifications of new uploads. Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

    TWiPO #93: CureWorks & Caring Cross: Pathways to Advance Cell & Gene Therapy with Dr. Rimas Orentas

    Play Episode Listen Later Jan 20, 2022 33:16


    WATCH THE VIDEO WEBCAST HERE: https://youtu.be/AFmMxBeZOa4 Tune in as our hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, meet with Dr. Rimas Orentas - the Scientific Director of Caring Cross & a Professor from Seattle Children's Hospital. In this episode, Dr. Orentas discusses his expertise in cellular gene therapy - the accessibility, production, testing, and the importance of diversity and inclusion amongst research subjects. Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads. Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

    TWiPO #92: mRNA - Not just for COVID - What is its Application in Pediatric Cancer? with Dr. Elias Sayour

    Play Episode Listen Later Jan 6, 2022 34:48


    WATCH THE VIDEO WEBCAST HERE: https://youtu.be/uk1dxJe3VoY Hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, meet with Dr. Elias Sayour from the University of Florida. While many are familiar with mRNA due to its COVID-19 vaccine application, Dr. Sayour discusses mRNA within the pediatric brain tumor landscape - including preclinical work, its delivery & distribution, as well as promising future opportunities for pediatric cancer patients. Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads. Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

    TWiPO #91: What Breakthroughs are on the Horizon for DIPG? with Dr. Mariella Filbin

    Play Episode Listen Later Dec 2, 2021 31:57


    WATCH THE VIDEO WEBCAST HERE: https://youtu.be/7NAibEpTA0w Hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, are joined by Dr. Mariella Filbin from Dana-Farber Cancer Institute/Boston Children's Hospital. Dr. Filbin discusses her expertise within DIPG including transcriptomics and epigenomics, as well as what is on the horizon for research - both challenging and exciting advances. Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads. Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

    TWiPO #90: Newborn Screening For Predisposition to Pediatric Cancers with Dr. Lisa Diller

    Play Episode Listen Later Nov 4, 2021 31:43


    WATCH THE VIDEO WEBCAST HERE: https://youtu.be/Fd1flMgbfLw Listen in as our hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, are joined in this episode by Dr. Lisa Diller from Dana-Farber/Boston Children's Cancer and Blood Disorders Center. Dr. Diller discusses the possibilities of genetic testing for pediatric cancer predisposition syndromes in newborn screening programs, but with uncertain benefits and costs. She recently authored a paper exploring mathematical modeling of a screening program for cost and benefit. You can read her full paper here: https://pubmed.ncbi.nlm.nih.gov/33767345/ ----more----EXCERPT: We developed a simulation model to evaluate universal screening for a CPS panel. Cohorts of US newborns were simulated under universal screening versus usual care. Using data from clinical studies, ClinVar, and gnomAD, the presence of pathogenic/likely pathogenic (P/LP) variants in RET, RB1, TP53, DICER1, SUFU, PTCH1, SMARCB1, WT1, APC, ALK, and PHOX2B were assigned at birth. Newborns with identified variants underwent guideline surveillance. Survival benefit was modeled via reductions in advanced disease, cancer deaths, and treatment-related late mortality, assuming 100% adherence. ----more----Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads. Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

    TWiPO #89: Spotlight on Immunotherapy for Pediatrics - Natural Killer T-Cells with Dr. Andras Heczey

    Play Episode Listen Later Aug 30, 2021 27:04


    WATCH THE VIDEO WEBCAST HERE: https://www.youtube.com/watch?v=nJZYz1XrsyY Hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, are joined in this episode by Dr. Andras Heczey from Texas Children's Hospital/Baylor College of Medicine. Listen in as they discuss Dr. Heczey's expertise & research in utilizing Natural Killer (NK) T-cells for pediatric immunotherapy treatment and the process of doing so. Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads. Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

    TWiPO #88: The ACCELERATE ALKi Pediatric Strategy Forum with Prof. Andy Pearson & Prof. Lou Chesler

    Play Episode Listen Later Jul 29, 2021 29:43


    WATCH THE VIDEO WEBCAST HERE: https://youtu.be/zZiE19fhzQQ Tune in to the latest TWiPO episode as hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, meet with Prof. Andy Pearson and Prof. Lou Chesler to discuss the ACCELERATE forums; Prof. Pearson & Prof. Chesler played pivotal roles in the start of the ALKi Pediatric Strategy Forum. Listen in as they discuss their experiences from the very first meeting, how topics are chosen, and the importance of bringing together key people from different industries. The ACCELERATE international platform provides a transparent forum to discuss and address, in a timely fashion, overarching issues in the development of innovative anticancer medicines for children and adolescents with cancer. To learn more about ACCELERATE, please visit: https://www.accelerate-platform.org/ ----more---- Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads. Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

    TWiPO #87: Biotech Solutions for Pediatric Cancer Drug Development with Dr. Samuel Blackman

    Play Episode Listen Later Jun 28, 2021 32:08


    WATCH THE VIDEO WEBCAST HERE: https://youtu.be/PbNS-yFDTzA Hosts Dr. Timothy Cripe & Dr. Brenda Weigel are joined by Dr. Samuel Blackman to discuss biotech solutions for pediatric cancer drug development. Dr. Blackman is the Co-Founder and Chief Medical Officer of Day One Biopharmaceuticals located in South San Francisco, CA. Tune in as Dr. Blackman discusses his career journey, the origins of Day One, and the challenges in pediatric cancer drug development today. To learn more about Day One Biopharmaceuticals, go to https://dayonebio.com/. Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads. Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

    TWiPO #85: Oncolytic Virotherapy in Pediatric BrainTumors with Dr. Gregory Friedman

    Play Episode Listen Later May 28, 2021 28:45


    WATCH THE VIDEO WEBCAST HERE: https://youtu.be/OSftR6JhEtY As Brain Tumor Awareness Month draws to a close, we bring you a new TWIPO episode on the subject. Hosts Dr. Timothy Cripe & Dr. Brenda Weigel are joined by Dr. Gregory Friedman from the University of Alabama in Birmingham to discuss his recently published paper “Oncolytic HSV-1 G207 Immunovirotherapy for Pediatric High-Grade Gliomas.” Listen in as Dr. Friedman discusses the findings of this phase 1 clinical trial and the progress of oncolytic virotherapy in pediatric brain tumors. You can access the abstract to Dr. Friedman's paper here: https://pubmed.ncbi.nlm.nih.gov/33838625/ Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads. Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

    TWiPO #85: Brain Tumors & The Blood-Brain Barrier with Dr. Stergios Zacharoulis

    Play Episode Listen Later May 14, 2021 30:08


    WATCH THE VIDEO WEBCAST HERE: https://youtu.be/TEFcsd5lt1A In recognition of Brain Tumor Awareness Month, TWIPO hosts Dr. Timothy Cripe and Dr. Brenda Weigel are joined by Dr. Stergios Zacharoulis of Columbia University Irving Medical Center (CUIMC), where he initiated a novel drug delivery program for pediatric brain tumors. Listen in as Dr. Zacharoulis discusses different delivery methodologies being explored and developed that bypass the blood brain barrier.   Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads. 

    ideas brain tumors blood brain barrier brain tumor awareness month
    TWiPO #84: An Introduction to the ACCELERATE Platform with Dr. Gilles Vassal & Patricia Blanc

    Play Episode Listen Later Mar 12, 2021 23:34


    Hosts Dr. Tim Cripe and Dr. Brenda Weigel met with Dr. Gilles Vassal and Patricia Blanc on the ACCELERATE Platform: Innovation for Children and Adolescents with Cancer. Dr. Gilles Vassal is the head of Clinical Research at Institut Gustave Roussy in Villejuif, France & he is also the Chair for the ACCELERATE Steering Committee. Patricia Blanc is the President & Founder of the Imagine for Margo Foundation and serves as a Patient Advocate for ACCELERATE. Listen in to hear how the ACCELERATE platform came to be & the advances they are making within the childhood cancer research landscape. The ACCELERATE international platform provides a transparent forum to discuss and address, in a timely fashion, overarching issues in the development of innovative anticancer medicines for children and adolescents with cancer. To learn more about ACCELERATE, please visit: https://www.accelerate-platform.org/  

    TWiPO #83 - Dr. Christopher Dandoy on transplant-associated thrombotic microangiopathy (TA-TMA)

    Play Episode Listen Later Jan 29, 2021 28:25


    Hosts Tim Cripe and Brenda Weigel welcome Dr. Chris Dandoy, from Cincinnati Children's Hospital, and parent advocate, Sarah Moore, to discuss the current research on TA-TMA and the implications for children undergoing stem cell transplant (SCT) for pediatric cancers, notably tandem SCTs for high-risk neuroblastoma.   Dr. Dandoy is Assistant Professor of Clinical Pediatrics in Bone Marrow Transplantation and Immune Deficiency at Cincinnati Children’s Hospital Medical Center and this episode discussion focused on four recently published papers by Dr. Dandoy describing effects, incidence, risk factors, screening, and treatment of this serious complication of transplants. Sarah Moore also shared her perspective as a mother to a child who recently underwent tandem SCT for high-risk neuroblastoma, and has been active in parent forums discussing the incidence and implications of TA-TMA and sharing evidence-based information.   Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org.   Subscribe to TWIPO to get notifications of new uploads.   Want to listen to TWIPO's past episodes? Visit www.solvingkidscancer.org/podcast

    TWiPO #82: Dr. Brenda Weigel on The RACE Act & Early Phase Clinical Trials

    Play Episode Listen Later Dec 8, 2020 32:10


    Host Tim Cripe welcomes his new Co-Host, Dr. Brenda Weigel, to reflect on her career, leadership, and focus areas since her last interview on TWiPO in 2017. Dr. Weigel is the Director of the Division of Pediatric Hematology/Oncology at the University of Minnesota's Cancer Center, Chair of Developmental Therapeutics in the COG, and Chair of the Pediatric Early Phase Clinical Trials Network (PEP-CTN) for the NCI.   She is at the epi-center for getting new drugs into the clinic for children with cancer and shares her perspective on the impact of the game-changing RACE Act that was implemented in 2020. She weighs in on prioritization of same-class drugs, evolving clinical trial design for small patient populations, and the increasing need for international collaboration in conducting clinical trials. She also discusses the importance of quality-of-life assessments and patient-reported outcomes and shares the efforts ongoing in the US and EU regulatory landscape to advance drug development for children with cancer.

    Discussing Brain Tumor Research with Dr. Michael Taylor & Dr. Nabil Ahmed

    Play Episode Listen Later Oct 30, 2020 29:53


    This week was International Brain Tumor Awareness Week & we're closing out the week with this engaging discussion. TWIPO Host, Dr. Timothy Cripe, met with Dr. Michael Taylor, from SickKids in Toronto, Canada, and Dr. Nabil Ahmed, from Texas Children's Hospital, to discuss their recently published paper on a novel immunotherapy approach for children with metastatic medulloblastoma and ependymoma. You can read their full paper here: https://pubmed.ncbi.nlm.nih.gov/32341580/

    TWIPO: Interview with Douglas Hawkins, MD - Chair of Children's Oncology Group (COG)

    Play Episode Listen Later Sep 30, 2020 25:53


    This Week in Pediatric Oncology (TWIPO) - our host, Timothy Cripe, MD, meets with the new Chair of the Children's Oncology Group (COG), Douglas Hawkins, MD, to discuss the future of the pediatric cancer research landscape.   Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads.   You can now watch TWIPO podcasts on our YouTube Channel! Watch this episode here & subscribe: https://youtu.be/p7rMXwAu3qA

    children md hawkins children's oncology group
    The Pandemic's Impact on the Pediatric Cancer Research Landscape

    Play Episode Listen Later Apr 28, 2020 62:51


    • How is the pandemic changing current cancer care services?• What is the current state of open clinical trials and how will new, near-term trials be affected?• What is the impact on emerging new therapies and translational research?• Are there any silver linings to all of this for childhood cancer research? These answers and more are discussed in this special episode for cancer families where leaders from COG, the NCI and the pharmaceutical industry lead a community discussion about the pandemic's impact on all aspects of pediatric cancer research including clinical trials and standard cancer care services, followed by Q&A with questions from families and attendees.   We are joined by:- Peter Adamson, MD – former Chair, Children's Oncology Group (COG) and current Global Head, Oncology Development & Pediatric Innovation, Sanofi - Mark Kieran, MD, PhD – Pediatric Clinical Trial Lead, Bristol Myers Squibb - Jeffery J. Auletta, MD - Director of the Blood and Marrow Transplant (BMT) Program and the Host Defense and Immunocompromised Infectious Diseases Program at Nationwide Children's Hospital. - Carol Thiele, Ph.D, Deputy Chief, National Cancer Institute (NCI) Pediatric Oncology Branch - Prof. Pamela Kearns President, European Society of Pediatric Oncology (SIOPE), Director of Cancer Research UK Clinical Trials Unit Moderated by: Timothy P. Cripe, MD, PhD – Chief of Hematology and Oncology at Nationwide Children’s Hospital Hosted by: Solving Kids' Cancer US & UK, and Max Cure Foundation

    Latest COVID-19 Insights from Doctors + Stories from the Frontline to inform Childhood Cancer Families & the General Community

    Play Episode Listen Later Mar 31, 2020 54:18


    Experts from the medical community will update us on our progress to-date and what to expect in the coming weeks and months. Also, parents from a New York family both diagnosed with COVID-19 will share their family’s current story/experience and important insights from the frontline.Please join this timely webinar to hear expert opinions, real-life descriptions, ask questions, and share information on:• Progress on containing and treating the virus• Could viruses like COVID-19 be the new normal?• Medical services to pediatric cancer patients – how much of a delay right now?• Clinical research trials for cancer and other diseases on hold – impact to getting new treatments developed• Sharing a personal story: Real life with COVID-19 from a family’s perspective in New YorkQ&A to followGuest Speakers:• Timothy P. Cripe, MD, PhD, Chief of Hematology and Oncology, Nationwide Children’s Hospital• Jeffery J. Auletta, MD, Director of the Blood and Marrow Transplant (BMT) Program and Host Defense and Immunocompromised Infectious Diseases – Nationwide Children’s Hospital• New York couple diagnosed with COVID-19 at home with their family

    Discussion on Impact of COVID-19 in the Pediatric Cancer Community

    Play Episode Listen Later Mar 24, 2020 58:20


    As our world faces the Novel Coronavirus pandemic, it’s vital that we address key topics important to children & families in the Pediatric Cancer CommunityPlease listen to this informative webinar to hear from experts, ask questions, and share information on:- An overview of COVID-19 pandemic: Fact versus fiction- COVID-19: What are the risks to immunocompromised patients?- Impact of COVID-19 on care and clinical researchExpert Discussion Leaders:Timothy P. Cripe, MD, PhD – Chief of Hematology and Oncology at Nationwide Children’s HospitalJeffery J. Auletta, MD - Director of the Blood and Marrow Transplant (BMT) Program and the Host Defense and Immunocompromised Infectious Diseases Program at Nationwide Children's Hospital.   This audio was taken from a webinar, to watch the full video with resources click here: https://vimeo.com/400382067

    TWiPO #76 - Rebecca Johnson & Becca Jacobsen discuss Adolescent/Young adult psycho-social support programs

    Play Episode Listen Later Jun 21, 2019 24:51


    Guest host Dr. Ryan Roberts welcomes Rebecca Johnson and Becca Jacobsen to a conversation about the benefits and contributions of AYA (Adolescent/Young Adult) psycho-social support programs which serve the needs and challenges within this demographic of cancer patients and survivors.

    TWiPO #75 - Interview with Dr. Robert Wechsler-Reya

    Play Episode Listen Later Mar 6, 2019 30:31


    Host, Dr. Timothy Cripe from Nationwide Children's Hospital, along with co-host - Dr. Nilay Shah, are joined by Dr. Robert Wechsler-Reya from Sanford Burnham Prebys in San Diego, CA. They discuss Dr. Wechsler-Reya's work including the process, benefits, and limitations of tumor models in mice, as well as research behind the humanized mouse model. They also discuss immune evasion - how one tumor type can grow in the presence of an immune system, while another one cannot. Listen in to learn more. Please send questions and comments to TWiPO@solvingkidscancer.org.

    TWiPO #74 - Interview with Abby Rosenberg

    Play Episode Listen Later Mar 6, 2019 30:58


    TWIPO Host Tim Cripe, alongside co-hosts Ryan Roberts and Lisa Humphrey, engage in an insightful conversation with guest Abby Rosenberg, Director, Palliative Care and Resilience Research at Seattle Children's Research Institute. Rosenberg, with Seattle Children’s colleague, Yi-Frazier, developed a promising systematic intervention program called PRISM (Promoting Resilience in Stress Management) for teens and young adults to better equip them with skills to manage their stress after a cancer diagnosis. PRISM has undergone pilot/feasibility studies and has received NIH funding for further study. Listen in to learn more. Please send questions and comments to TWiPO@solvingkidscancer.org.  

    TWiPO #73 - Dr. Peter Adamson comes back to talk about progress, the drug shortage, families' impact, and so much more

    Play Episode Listen Later Mar 2, 2018 41:26


    Host, Dr. Timothy Cripe from Nationwide Children's Hospital, along with his co-hosts - Dr. Ryan Roberts, Dr. Nilay Shah, Dr. Keri Streby, and Dr. Mark Ranalli, interview Dr. Peter Adamson from Children's Hospital of Philadelphia. Dr. Adamson was previously interviewed back in 2011, in Podcast #9, and they discuss the progress that has been made since then. Dr. Adamson goes on to talk about private-public partnerships, families' impact on the field, the drug shortage problem, and much more. Tune in to this podcast to learn more about all of these interesting topics.

    TWiPO #72 - Dr. Eugene Hwang discusses his work with immunotherapy and pseudo-progression

    Play Episode Listen Later Feb 1, 2018 24:01


    Hosts, Dr. Timothy Cripe, Dr. Keri Steby, Dr. Ryan Roberts, and Dr. Jonathan Finlay from Nationwide Children's Hospital are joined by Dr. Eugene Hwang, who is a pediatric hematologist-oncologist at the Children's National Medical Center in Washington D.C. Dr. Hwang discusses his work with immunotherapy and pseudo-progression, as well as explains the basics of a solid tumor clinical trial he created in conjunction with Dr. Catherine Bollard. Listen in to learn more.

    TWiPO #71 - Interview with Nancy Goodman, Founder and Executive Director of Kids v. Cancer

    Play Episode Listen Later Dec 21, 2017 34:25


    Host, Dr. Timothy Cripe, from Nationwide Children's Hospital in Columbus, Ohio had the honor of interviewing Nancy Goodman, Founder and Executive Director of Kids v. Cancer in Washington DC.

    TWiPO #70 - Dr. Joshua Rubin talks about his research done on gender differences to cancer

    Play Episode Listen Later Dec 15, 2017 37:49


    Dr. Joshua Rubin, from Washington University, discusses his research done of gender differences to cancer that go beyond hormonal differences

    TWiPO #69 - Dr. Peter Shields talks about the effects of e-cigarettes

    Play Episode Listen Later Nov 29, 2017 34:44


    Dr. Shields discusses his research on cigarettes and the effects of e-cigarettes among its users, the youth, and the economy.

    TWiPO #68 - Dr. Dean Lee discusses his experience with T-cell CARs

    Play Episode Listen Later Nov 15, 2017 50:29


    Host Dr. Timothy Cripe and Dr. Nilay Shah, from Nationwide Children's Hospital in Columbus, Ohio, is joined by Dr. Dean Lee to discuss their experience with T-cell CARs (Chimeric Antigen Receptors).

    TWiPO #67 - Interview with Dr. Mitchell Cairo

    Play Episode Listen Later Nov 15, 2017 27:44


    Hosts Dr. Nilay Shah, Dr. Ryan Roberts, and Dr. Keri Streby from Nationwide Children’s Hospital in Columbus, Ohio, sit down with Dr. Mitchell Cairo to discuss his experiences within the pediatric cancer research sector.

    TWIPO #66 - Interview with Dr. Rani George

    Play Episode Listen Later Oct 2, 2017 17:35


    Host Dr. Ryan Roberts, from Nationwide Children's Hospital in Columbus, Ohio, is joined by Dr. Rani George to discuss her experience with studying neuroblastoma and how she got involved in the field of oncology. George discusses her thoughts on what is needed to progress pediatric cancer research - including relapse biopsies, understanding the biology, and, of course, funding. As Dr. Roberts says, what we need is, "...more time, more patience, and more funding."  Please send questions and comments to TWiPO@solvingkidscancer.org 

    TWiPO #65 - Interview with Dr. Brenda Weigel

    Play Episode Listen Later Oct 2, 2017 34:47


    In this podcast, co-Hosts Dr. Robyn Dennis and Dr. Ryan Roberts had the honor of interviewing Dr. Brenda Weigel, Director of the Division of Pediatric Hematology/Oncology at the University of Minnesota. Dr. Weigel discusses her “serendipitous” background story of how she became involved in childhood oncology, as well as talks about the challenges the field faces with managing new cancer therapies. But, despite the challenges, she is hopeful that we are moving away from chemotherapy treatments into an era of cancer therapies that “hopefully, has the potential to cure the cancers and improve the quality of life”. 

    TWiPO #64 - Interview with Dr. Lars Wagner

    Play Episode Listen Later Jul 17, 2017 26:10


    It’s an exciting time to be part of the childhood cancer research community, and this interview was focused on career advice for those interested in childhood oncology and research. The availability of genomic profiling of tumors, targeted agents and the development of new immunotherapies are increasing the opportunities available to patients today. This lively discussion addresses the importance of preclinical data, predictive biomarker studies and the measurement of responses, with specific references to Dr. Wagner’s experience with studying irinotecan.   Dr. Wagner also answered questions about radiomics and how this imaging trend can provide more insights for enhanced radiology reporting. Please send questions and comments to TWiPO@solvingkidscancer.org 

    TWiPO #63 - Dr. Javier Blanco discusses chemotherapy late effects and cardio-toxicity

    Play Episode Listen Later Jul 17, 2017 24:27


    Co-Hosts Dr. Timothy Cripe and Dr. Randal Olshefski (Nationwide Children's Hospital), interview Dr. Javier Blanco, Associate Professor at the Department of Pharmaceutical Sciences at SUNY Buffalo, about the late effects of chemotherapy.  In this podcast, the participants discuss the role that chemotherapy, such as doxorubicin and other anthracycline drugs, often play in increasing cardio-toxicity.

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