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When does life begin? In this episode of Stanford Legal, co-hosts Rich Ford and Pam Karlan dig into the recent decision by the Alabama Supreme Court that has sent shockwaves through the fertility treatment community. The ruling, which considers frozen embryos as children under state law, has wide-ranging implications for in vitro fertilization (IVF) practices. Bioethics and law expert Hank Greely joins the discussion, providing insights into the background of the case, its legal implications, and the potential ramifications for IVF clinics and patients in Alabama—and throughout the country. The conversation highlights the intersection of law, medicine, and ethics, revealing the complex challenges surrounding embryo rights and reproductive freedoms.Connect:Episode Transcripts >>> Stanford Legal Podcast WebsiteStanford Legal Podcast >>> LinkedIn PageRich Ford >>> Twitter/XPam Karlan >>> Stanford Law School PageStanford Law School >>> Twitter/XStanford Law Magazine >>> Twitter/XLinks:Hank Greely >>> Stanford Law School Page | Twitter/X(00:00:00) Chapter 1: Introduction & The Alabama Supreme Court RulingHank Greely, discussing the recent Alabama Supreme Court decision regarding frozen embryos. He provides background on the Alabama Supreme Court decision and the implications for fertility treatment in the state along with explaining the legal basis of the ruling and the claims brought forth by the plaintiffs.(00:03:43) Chapter 2: Wrongful Death Act & Implications of the DecisionDiscussion on the Alabama Wrongful Death Act and its application to unborn children, including frozen embryos. Exploration of the broader implications of the decision, including ethical and legal concerns.(00:08:21) Chapter 3: Understanding Frozen EmbryosHank Greely explains the process of in vitro fertilization (IVF) and the concept of frozen embryos, including the harvesting of eggs and the reasons for freezing embryos.(00:14:05) Chapter 4: Legal and Ethical ConcernsAnalysis of the legal and ethical implications of the Alabama decision for IVF clinics and patients. Greely, Karlan, and Ford then discuss the political and legislative responses to the Alabama decision, including potential future actions(00:26:49) Chapter 5: Gender and Control Over ReproductionShow Notes: Discussion on the gender dynamics and control over reproduction highlighted by the Alabama Supreme Court ruling.(00:33:29) Chapter 6: Political Ramifications and PredictionsHank Greely offers his perspective on potential legislative responses and the broader implications for reproductive rights. From congressional bills to grassroots activism, we explore the evolving landscape of reproductive justice. They also explore the political ramifications and the future outlook for fertility treatment.
Are you as precious as a frozen embryo? Alabama's Supreme Court has ruled that fertilized eggs as a result of IVF are children (!) and Republicans are scrambling to do damage control for their dystopian playbook coming true. Moji Alawode-El of Abortion Access Front joins Francesca to discuss. And Lance of The Serfs TV talks transphobe Chaia Raichik's interview with journalist Taylor Lorenz, and the brief and courageous life of Aaron Bushnell who self-immolated in protest of the genocide in Gaza. Featuring: Lance, The Serfs, https://twitter.com/theserfstv Moji Alawode-El, Abortion AF https://twitter.com/AbortionFront ** Francesca will be at the SACRAMENTO PUNCHLINE with Matt Lieb, SUNDAY MARCH 17TH at 7pm. Don't miss it. Tickets here. ** Get 20% off SUNSET LAKE CBD with code FRANTIFA at check out. Explore all their organic, vertically-integrated craft CBD products including tinctures, gummies, smokables, salves and more: www.sunsetlakecbd.com *** Make life easy when it comes to meal planning. Give Factor Meals a try and get 50% of your order with code bitchuation50: https://www.factor75.com/ **** The Bitchuation Room Streams LIVE every TUESDAY and FRIDAY at 1/4pmEST on YouTube: https://www.youtube.com/franifio and Twitch: https://www.twitch.tv/franifio Support The Bitchuation Room by becoming a Patron: www.patreon.com/bitchuationroom to get special perks and listen/watchback privileges of the Friday *BONUS BISH* Tip the show via Venmo:@TBR-LIVE Cash-App:@TBRLIVE Music by Nick Stargu Follow The Bitchuation Room on Twitter @BitchuationPod, Instagram: @BitchuationRoom , TikTok: @BitchuationRoom Get your TBR merch: www.bitchuationroom.com
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.08.04.552031v1?rss=1 Authors: Lang, C. F., Anneken, A., Munro, E. Abstract: The PAR polarity network is a paradigmatic example of how systems of mutually antagonism interactions among peripheral membrane binding proteins allow them to form and maintain complementary polar domains in response to a transient polarizing cue. The oligomeric scaffolding protein PAR-3 has emerged as a keystone member of the PAR network in many different contexts. In early C. elegans embryos, PAR-3 is required for all other PAR asymmetries, and it can form stable unipolar asymmetries when its known inhibitors are absent and all other members of the PAR network are cytoplasmic or spatially uniform on the membrane. But how PAR-3 forms stable unipolar asymmetries absent mutual antagonism is unknown. Here we combine single particle analysis with quantitative modeling and experimental manipulations to determine how the dynamics of PAR-3 membrane binding, oligomerization and dissociation allow PAR-3 to maintain stable asymmetries in the one cell C. elegans embryo. We find that two forms of positive feedback contribute to sustaining PAR-3 asymmetries: First, a sharp size-dependent decrease in oligomer dissociation rates makes the effective dissociation rate of PAR-3 decrease sharply with its membrane density. Second, membrane-bound PAR-3 promotes additional binding of PAR-3 to the membrane through a mechanism that requires the presence of anterior polarity proteins CDC-42, PAR-6 and PKC-3. Through a combination of modeling and quantitative measurements, we show that these two feedback loops are sufficient to dynamically stabilize asymmetries of the magnitude observed in polarized C. elegans zygotes. These results establish a dynamic basis for stabilizing monopolar PAR-3 asymmetries; they underscore a crucial role for the oligomerization and add to the growing body of evidence that point to a central role for oligomerization of peripheral membrane proteins in the establishment and maintenance of cell polarity. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.21.533625v1?rss=1 Authors: Rosfelter, A., de Labbey, G., Chenevert, J., Dumollard, R., Schaub, S., Machaty, Z., Besnardeau, L., Hebras, C., Turlier, H., Burgess, D., mcdougall, a. Abstract: Although it has been studied for more than a century, the question of how one cell divides into two equal parts is still not fully resolved. Zygotes have provided much of the mechanistic insight into how the mitotic apparatus finds the center of the cell since the centrally-located mitotic apparatus is created from a large sperm aster that forms at the cortex and thus far from the zygote center. Here we show that in ascidians, the sperm aster extends throughout the cytoplasm during interphase yet remains located near the cortex and does not migrate towards the zygote center. It is only at mitotic entry, when the sperm aster has duplicated and the mitotic apparatus is being assembled, that most of the migration and centration occurs. This temporal pattern of centration behavior is mirrored by primate zygotes (including human). The current mechanisms of aster centration include cytoplasmic pulling that scale with microtubule (MT) length, MT pushing against the proximal cortex or MT-based cortical pulling. However, it is not yet known whether and how these 3 mechanisms are coordinated to prevent aster migration during interphase and trigger migration at mitotic entry. By monitoring quantitatively all three mechanisms (cytoplasmic pulling, pushing and cortical pulling) we have discovered that cortical pulling is switched off as the zygote enters mitosis while both cytoplasmic pulling and proximal cortical pushing remain active. Physical simulations could recapitulate both the static and migratory aspects of sperm aster and mitotic apparatus behavior. We therefore surmise that the reduction in cortical pulling at mitotic entry represents a switch that allows proximal cortical pushing forces and cytoplasmic pulling forces to center the nascent mitotic apparatus. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Was there a conspiracy — even if it only involved a handful of people — at the highest levels of our government to end the American Experiment that was only defeated by sheer luck? Also is Hershel Walker guilty of voter fraud? And will people be required to bury zygotes?See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
In this Episode we give our final thoughts on America's Number one hero Star and Stripe and give discuss the latest events in Chapter 335 of My hero Academia. YouTube: https://youtube.com/channel/UCxCPRc6yFI9Ig_qHnuuLCoQ
Hey y'all, welcome to the third episode of our miniseries! Join Nicole and Fern as they discuss the latest manga update for My Hero Academia/Boku no Hero Academia: Chapter 335, "Zygotes". Thanks for listening!
Christina Sasso comes on the show to talk about her transition from high school science teacher to fitness instructor. We talk about certifications, working with gyms and the woes of parent teacher conferences.
A fixture in the Brooklyn open mic scene, California kid Sam Rosen sits down for a discussion with Elann about hitting the streets to protest, being a textbook Scorpio, and "baby's first busk". In lieu of clips, Sam opted to instead play a handful of compositions that were originally recorded as voice memos, while they were attending Sarah Lawrence College. Featuring 3 different guitars and a brand new song called "Rats on the Tracks". RIP Johnny Nash. And finally, donate to www.theokraproject.com.
We were all once a sperm & egg combination, mmmmkkayy..
Welcome to the Episode 37 of the Tipsy Timeline! Have you ever wondered where hard apple cider come from? Well in today's episode we'll discuss the fascinating history (and biology!) of hard ciders and how they came to be so popular!
Pastor Joey delivers a stirring message in celebration of ALL Moms: biological, adopted and spiritual and how they reflect the love given by God.
Zygotes, sports, Hot Topic, and the Sniffen brothers. What do these things have in common? The idiots who do this podcast will talk about them instead of Warhammer 40k! In this episode Dan is physically conjoined to Campbell for all eternity. We talk NOVA, what we've been rushing to paint for NOVA, and introduce the first ever 40k Badcast GLobal Campaign! Be sure to go to 40kbadcast.com to get the rules for the first mission! Tim's sweet fuckin' Primaris Sergeant: http://imgur.com/CSq1qHu Look at our tweets! https://twitter.com/DB_Sleazy https://twitter.com/BrotherSRM Go watch Campbell's videos! https://www.youtube.com/channel/UC1Hd9_8GYNPVLGtD1sEDK_A Go Look at Campbell's tumblr! http://cam2d.tumblr.com/ Email us things! contact@40kbadcast.com
This time, Charles and Jesse discuss "Knock Knock", the fourth episode from Doctor Who Series Ten, starring Peter Capaldi as the Twelfth Doctor, Pearl Mackie as Bill Potts, and Matt Lucas as Nardole!
This time, Charles and Jesse discuss "Thin Ice", the third episode from Doctor Who Series Ten, starring Peter Capaldi as the Twelfth Doctor, Pearl Mackie as Bill Potts, and Matt Lucas as Nardole!
Charles and Jesse are back to discuss "The Power of Kroll", the fifth serial from the classic Doctor Who storyline "The Key to Time" in 1978, starring Tom Baker as the Fourth Doctor and Mary Tamm as the First Romana!
This time, Charles and Jesse discuss "The Stones of Blood", the third serial from the classic Doctor Who saga "The Key to Time" in 1978, starring Tom Baker as the Fourth Doctor, Mary Tamm as the First Romana, and John Leeson as the voice of K-9. They also discuss the passing of Sir John Hurt, the War Doctor, along with Peter Capaldi leaving Doctor Who, and the latest Series Ten and Eleven news.
This time, Charles and Jesse discuss "The Pirate Planet", the second serial from the classic Doctor Who saga "The Key to Time" in 1978, starring Tom Baker as the Fourth Doctor, Mary Tamm as the First Romana, and John Leeson as the voice of K-9. Charles' Twitter is @CharlesSkaggs Jesse’s Twitter is @JesseJacksonDFW Show’s Twitter is @NextStopSMG Email us at southgatemediagroup@gmail.com Please go to iTunes to rate and review us!
Come on, Texas! Stop being so predictable. This episode we visit the current laws that Texas and Utah are trying to pass. We reminisce about the good old days when people could just have non-shameful sex next to the radio listening to... Stratton and Bramble? Or maybe something a little more entertaining. DONATE to LPJ: https://www.ladypartsjustice.com/ Tom Price: http://nymag.com/thecut/2016/11/health-secretary-pick-tom-price-on-abortion-birth-control.html Texas: https://news.vice.com/story/texas-wants-abortion-providers-to-bury-or-cremate-fetal-remains Utah: https://rewire.news/article/2016/11/29/utah-gop-pushing-bill-claiming-can-undo-abortion-care/ Operation Rescue: https://www.rawstory.com/2016/11/operation-rescue-activist-who-plotted-to-bomb-an-abortion-critic-rages-at-being-called-a-terrorist/ ACLU, Planned Parenthood and Center for Repro Rights http://www.huffingtonpost.com/entry/abortion-rights-lawsuit_us_583ef56ee4b04fcaa4d5f968 Email us at podcast@ladypartsjustice.com
Come on, Texas! Stop being so predictable. This episode we visit the current laws that Texas and Utah are trying to pass. We reminisce about the good old days when people could just have non-shameful sex next to the radio listening to... Stratton and Bramble? Or maybe something a little more entertaining. DONATE to LPJ: https://www.ladypartsjustice.com/ Tom Price: http://nymag.com/thecut/2016/11/health-secretary-pick-tom-price-on-abortion-birth-control.html Texas: https://news.vice.com/story/texas-wants-abortion-providers-to-bury-or-cremate-fetal-remains Utah: https://rewire.news/article/2016/11/29/utah-gop-pushing-bill-claiming-can-undo-abortion-care/ Operation Rescue: https://www.rawstory.com/2016/11/operation-rescue-activist-who-plotted-to-bomb-an-abortion-critic-rages-at-being-called-a-terrorist/ ACLU, Planned Parenthood and Center for Repro Rights http://www.huffingtonpost.com/entry/abortion-rights-lawsuit_us_583ef56ee4b04fcaa4d5f968 Email us at podcast@ladypartsjustice.com
The Time Warrior - Next Stop Everywhere: The Doctor Who Podcast This time, Charles and Jesse discuss the 1973 classic from the original series of Doctor Who, starring Jon Pertwee as the Third Doctor and Elisabeth Sladen as Sarah Jane Smith. Charles' Twitter is @CharlesSkaggs Jesse’s Twitter is @JesseJacksonDFW Show’s Twitter is @NextStopSMG Email us at southgatemediagroup@gmail.com Please go to iTunes to rate and review us!
The Thousand Worlds - Next Stop Everywhere: The Doctor Who PodcastThis time, Charles and Jesse discuss the second episode of "Only the Monstrous," the first War Doctor audio adventure set from Big Finish Productions, starring John Hurt and Carolyn Seymour.Charles Twitter is @CharlesSkaggsJesse’s Twitter is @JesseJacksonDFW Show’s Twitter is @NextStopSMG Email us at southgatemediagroup@gmail.com Please go to iTunes to rate and review us!
The Unicorn and the Wasp - Next Stop Everywhere: The Doctor Who Podcast This time, Charles and Jesse are joined by special guest companion Lola Lariscy from ScannerDrome as we discuss the Tenth Doctor and Donna Noble story from 2008, starring David Tennant and Catherine Tate. Charles Twitter is @CharlesSkaggs Jesse’s Twitter is @JesseJacksonDFW Show’s Twitter is @NextStopSMG Please go to iTunes to rate and review us!
I attended a night of music on Friday Feb 19. First I went to Yellow Cab Tavern for SKRT, the Zygotes, and Manray. The Zygotes and Manray were both releasing new music to the packed all ages show. Then I headed to Blind Bobs for the bands Gay Black Republicans, the Involuntarys, Duderus, and Grand Mammoth. On Sat Feb 20, the crew went to the 2016 Independent Creators Expo and Film Festival at the Crowne Plaza in Downtown dayton. We recorded content to be released later, and we also released an episode of Epic and the Beard. This one will be called Izzy and the Beard After the Independent Creators Expo, I went to W.O. Wrights in Fairborn, Ohio for the Violent Kind, Swimming With Sharks, Good English, and Nightbeast Izzy Rock and Mark DaGrossa recorded this two part episode at the Montessori School of Dayton for the 2016 Dayton Brew HaHa. "The Dayton Brew Ha-Ha is an annual fundraiser for the Montessori School of Dayton. The event started in 2011 and raises funds for the school?s capital improvement fund. Although each year has seen exponential growth, we are committed to maintaining the event as a premier boutique beer tasting, where residents of our community can come to mingle, try regional and local beers, and learn more about the school and about craft beer. Our beers have always had a regional focus. Previous iterations have seen offerings from the Great Lake States, as well as a Michigan vs. Ohio showdown (2014) and Daytonâ??s first All Ohio tasting (2015). In 2016, they returned to their Midwestern roots, showcasing the best our region has to offer." Mike Schwartz and wife - Belmont Party Supply, Ollieâ??s Place Myron (Bar manager of Archerâ??s) Dave Tickel (Fifth St BrewPub Manager) Ryan (Warped Wing delivery driver) Vivienne (Dayton.com, Babbling April) Nate (Wretched Few, Archerâ??s Tavern) John (Dayton Beer Company) David Boston (Bostonâ??s Bistro) Mike (Brewer-Hairless Hare) Jeff P (Owner-Crooked Handle) Kylie Klinger @HopNugget Jeff Rudolf (Sam at Eleven) Jessica Rudolf Recorded on location 2900 Acosta St, Dayton, OH 45420 http://brewhahadayton.com/ https://www.facebook.com/brewhahadayton/ http://www.montessoridayton.com/ Host Mark DaGrossa - https://twitter.com/MarkDaGrossa Produced and hosted by Izzy Rock https://twitter.com/TheIzzyRock https://www.facebook.com/TheIzzyRock https://www.facebook.com/TalesFromTheHardsidePodcast Email and Booking: theizzyrock@gmail.com and izzy@gemcitypodcast.com Website:http://www.theizzyrock.com/ Call the voicemail: 937-265-2024 http://gemcitypodcast.com/ iTunes- https://itunes.apple.com/us/podcast/gem-city-podcast/id646008927?mt=2 Stitcher- http://www.stitcher.com/podcast/eric-ruiz/gem-city-podcast Twitter- https://twitter.com/GemCityPodcast Facebook- https://www.facebook.com/GemCityPodcast YouTube- https://www.youtube.com/user/TheGemCityPodcast Instagram- https://instagram.com/gemcitypodcast/
The Husbands of River Song - Next Stop Everywhere: The Doctor Who Podcast This time, Charles and Jesse discuss the 2015 Christmas Special starring Peter Capaldi and Alex Kingston, featuring the return of River Song. Learn more, subscribe, or contact us atwww.southgatemediagroup.com. We also have a tumblr now at southgatemediagroup.tumblr.com. You can write to us at southgatemediagroup@gmail.com and let us know what you think. Be sure to rate us and review the episode. It really helps other people find us. Thanks! @NextStopSMG @CharlesSkaggs @JesseJacksonDFW
Background: In mammals the parental genomes are epigenetically reprogrammed after fertilization. This reprogramming includes a rapid demethylation of the paternal (sperm-derived) chromosomes prior to DNA replication in zygotes. Such active DNA demethylation in the zygote has been documented for several mammalian species, including mouse, rat, pig, human and cow, but questioned to occur in rabbit. Results: When comparing immunohistochemical patterns of antibodies against 5-methyl-cytosine, H3K4me3 and H3K9me2 modifications we observe similar pronuclear distribution and dynamics in mouse, bovine and rabbit zygotes. In rabbit DNA demethylation of the paternal chromosomes occurs at slightly advanced pronuclear stages. We also show that the rabbit oocyte rapidly demethylates DNA of donor fibroblast after nuclear transfer. Conclusion: Our data reveal that major events of epigenetic reprogramming during pronuclear maturation, including mechanisms of active DNA demethylation, are apparently conserved among mammalian species.