Hey OA

This special episode was recorded live during the OARSI Rehabilitation Discussion Group's journal club on October 9th, 2023. Drs. Mel Holden, Martin Englund, David Hunter, and Miriam Hattle discuss the publication "Moderators of the effect of therapeutic exercise for knee and hip osteoarthritis: a systematic review and individual participant data meta-analysis" by Holden and colleagues. Publication: https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(23)00122-4/fulltext OARSI Rehab discussion group: https://oarsi.org/membership/discussion-groups#Rehab

Dr. Mick Jurynec from the University of Utah explains what we can learn about the role of genetics in osteoarthritis from families that have multiple relatives affected by osteoarthritis and from model organisms like zebrafish. For more information visit: juryneclab.org. This episode was edited by Dr. Jade He.

Key stakeholders discuss the motivation for the OARSI Clinical Trials Symposium and what to expect for this year's event in October 2021. Learn more and register at: https://oarsi.org/2021-clinical-trials-symposium

Dr. Kelsey Collins, a postdoctoral researcher at Washington University in St. Louis, USA, discusses the findings of her recent publication in PNAS, titled 'Adipose tissue is a critical regulator of osteoarthritis', including the unique mouse model used and what this tells us about the role of fat tissue in OA. https://www.pnas.org/content/118/1/e2021096118/tab-article-info

Researchers from Keele University discuss their work developing a repository of online osteoarthritis management programmes in response to the COVID-19 pandemic. Dr. Krysia Dziedzic, Dr. Jonathan Quicke, Laura Campbell, and Dr. Laura Swaithes undertook this work as part of the Joint Effort Initiative Implementation subgroup. Learn more at: https://www.keele.ac.uk/pcsc/research/impactacceleratorunit/oamps/

Dr. Ida Haugen, MD, PhD, discusses osteoarthritis of the hand. Find more on twitter @IdaBosHaugen or at https://revmabloggen.com (in Norwegian).

Following the cancellation of the 2020 World Congress on Osteoarthritis, OARSI president Dr. Ali Mobasheri discusses how OARSI is adapting to the COVID-19 pandemic, including the introduction of new initiatives and programs and planning for the future. Find out more at oarsi.org.

Dr. Samantha Bunzli, PhD, a physiotherapist and post-doctoral researcher at the University of Melbourne discusses qualitative research in osteoarthritis and other musculoskeletal conditions. For more info on Dr. Bunzli’s research and qualitative research in general, see: https://journals.lww.com/clinorthop/Fulltext/2019/09000/Editor_s_Spotlight_Take_5__Misconceptions_and_the.2.aspx https://opus-tjr.org.au/ http://www.lowbackpaincommunication.com/

Dr. Jonathan Bjerre-Bastos, MD, current PhD student at the University of Copenhagen, and OARSI Young Investigator Award Winner, discusses measuring biomarkers to understand the effects of physical activity on joint health.

Dr. Ali Mobasheri, current OARSI president and Professor, Project Leader, and Senior Research Scientist in the Department of Regenerative Medicine at the State Research Institute Centre for Innovative Medicine in Vilnius, Lithuania, discusses his research in Lithuania, Finland, and the UK, how his experiences as an OA patient, journal editor, reviewer, and instructor fit into his career, and his plans for the further internationalization of OARSI. More information can be at the following websites: https://www.oarsi.org/about/board-directors https://www.linkedin.com/in/ali-mobasheri-68009712/ http://www.imcentras.lt/research-council/department-of-regenerative-medicine/ http://www.approachproject.eu/about/governance http://www.sportsarthritisresearchuk.org/centre-staff/partners.aspx

Ms. Penny Campbell, research trial coordinator at the Centre for Health, Exercise and Sports Medicine within the Department of Physiotherapy at The University of Melbourne in Australia, shares her expertise in conducting clinical trials (particularly randomized controlled trials) and discusses things to consider when setting up a trial of your own. More information about Ms. Campbell’s work can be found at: https://healthsciences.unimelb.edu.au/departments/physiotherapy/about-us/chesm and https://www.facebook.com/CHESMunimelb/

Dr. Søren T. Skou, Associate Professor at the University of Southern Denmark and head of a multiprofessional research group at Næstved-Slagelse-Ringsted Hospitals, discusses exercise therapy for individuals with osteoarthritis and the success of the Good Life with osteoArthritis in Denmark (GLA:D®) program, which has now spread to multiple countries. Find Dr. Skou on twitter @stskou and find more information about GLA:D at: https://www.glaid.dk/english.html (Denmark), https://gladcanada.ca/ (Canada), https://gladaustralia.com.au/ (Australia), http://www.gladschweiz.ch/ (Switzerland)

Prof. Dr. Henning Madry, an MD, tenured professor, and Director of the Center of Experimental Orthopaedics at Saarland University in Germany, describes the new OARSI-affiliated journal Osteoarthritis and Cartilage Open and how his background in both basic science research and as a clinician prepared him to serve as the journal’s editor. More information about Prof. Madry’s research can be found at www.uks.eu/ieo and about the journal (including contact information) at www.journals.elsevier.com/osteoarthritis-and-cartilage-open.

Dr. Tuhina Neogi, program chair for the 2019 OARSI World Congress on Osteoarthritis, previews the upcoming conference.

Dr. Jill Halstead, a clinical academic podiatrist who works in the National Health Service and is a visiting research fellow affiliated to the University of Leeds in the UK, talks everything you want to know about osteoarthritis of the foot. If you are interested in more about foot OA, you can follow Jill on twitter @HalsteadDr and check out the International Foot and Ankle OA Consortium discussion group meeting at OARSI 2019.

Dr. Jeroen Geurts, head of biomolecular osteoarthritis research at the departments of orthopaedic and spine surgery and biomedical engineering at the University Hospital of Basel in Switzerland talks about OA of the spine, bone marrow, creating ex vivo models of OA from surgical specimens, the potential of osteoimmunology in OA, and the importance of networking. You can find out more on twitter @OA_Lab_Basel or at https://www.mdpi.com/1422-0067/19/5/1314/xml.

Ms. My-Linh Luong, a health behavior researcher and PhD candidate at the Centre for Health, Exercise, and Sports Medicine at the University of Melbourne in Melbourne, Australia shares her experience of working on her PhD outside of her home country. You can find her on twitter @mylinhluong

Mr. Anthony Gatti, a PhD candidate in the School of Rehabilitation Science at McMaster University in Hamilton, Ontario, talks about machine learning, the challenges of analyzing magnetic resonance imaging data, and what it’s like to start your own company while you are still in school. You can find out more about his work at www.neuralseg.com or catch up with him on twitter @sportmedgeek.

Dr. Frank Beier, a professor and chair of physiology and pharmacology at the University of Western Ontario, discusses the links between genetics, biology, and OA, including how skeletal and cartilage development can provide clues to osteoarthritis, links between mechanics and biology, and how the same pathways can act in different ways in aging versus surgical models of osteoarthritis. You can find out more about Dr. Beier’s work at http://uwo.ca/physpharm/beier or follow him on twitter @BeierLab.

Dr. Elise Laende, a research manager in the Department of Orthopaedic Surgery at the Nova Scotia Health Authority (and recent PhD graduate), discusses how to use radiostereometric analysis (RSA) to monitor total knee arthroplasty (TKA) implant migration, the importance of collecting long-term outcome data, and sex differences in TKA. Find out more about RSA at http://www.canadianrsanetwork.com and http://radiostereometry.org. Dr. Laende’s blog, the Evidence-based Feminist and the link to the “standard patient” research article that she mentioned can be found at http://evidencebasedfeminist.blogspot.com.

Dr. Jackie Whittaker, an assistant professor of physical therapy at the University of Alberta, compares primary, secondary, and tertiary OA prevention, discusses the challenges and opportunities for research with youth populations, and chats about using Twitter for research. You can find her at https://www.ualberta.ca/rehabilitation/about-us/contact-us/faculty-directory/jackie-whittaker or on twitter @jwhittak_physio

Dr. Jamie MacKay, a musculoskeletal radiologist and clinical research fellow (and 3rd year PhD student!) in the Department of Radiology at the University of Cambridge, discusses career decisions, musculoskeletal imaging, and preparing for his upcoming OARSI collaborative scholarship at Stanford University. You can find out more about Dr. MacKay and his research on twitter (@dr_jamie_mackay) or at http://radiology.medschl.cam.ac.uk/about-us/departmental-staff/phd-students/jamie-mackay. The systematic review and meta-analysis paper that was mentioned can be found at: https://www.oarsijournal.com/article/S1063-4584(18)31069-0/abstract

Dr. Timothy Griffin, an associate member of the Oklahoma Medical Research Foundation and Adjunct Associate Professor at the University of Oklahoma, discusses metabolism and inflammation in osteoarthritis, animal models of obesity, and what it’s like to work at a private, non-profit research foundation. More information about Dr. Griffin's research can be found at: https://griffint.omrf.org/

Dr. Gillian Hawker, a clinician scientist, professor, and chair of medicine at the University of Toronto, discusses why we need to classify OA as a serious disease, the need for consistent definitions of OA, and remaining sources of bias in the treatment of women with OA. Find more about the OARSI white paper at: https://www.oarsi.org/research/oa-serious-disease This podcast is made possible with funding from Flexion. 

Dr. Tuhina Neogi, professor of medicine at Boston University’s School of Medicine and professor of epidemiology at Boston University’s School of Public Health, shares her knowledge about imaging, pain, and mentoring. Find out more at: https://profiles.bu.edu/Tuhina.Neogi http://blog.arthritis.org/news/arthritis-research-tuhina-neogi/

Dr. Carla Scanzello, Section Chief of Rheumatology at the Corporal Michael J. Cresenz (Philadelphia) VA Medical Center, assistant professor at the University of Pennsylvania Perelman School of Medicine, and current program chair for the 2018 OARSI World Congress on Osteoarthritis discusses what’s in store at the upcoming conference and what not to miss! The congress runs from April 26th to Sunday April 29th, 2018 in Liverpool, UK. More information can be found at: https://2018.oarsi.org/

Professor Peter Choong, MD, lead chief investigator for OPUS, the Centre of Research Excellence in Total Joint Replacement, discusses how research can help optimize outcomes, equity, cost-effectiveness, and patient selection for joint replacement. More information about Professor Choong’s research and OPUS can be found at medicine.unimelb.edu.au/surgery/opus or on twitter @OPUSunimelb

Three young investigators (early career researchers) share their experiences of working with the Osteoarthritis Initiative Data. (00:17) Michelle Yau, PhD, is a post-doctoral research fellow in the Musculoskeletal Research Group at Hebrew Senior Life, an affiliate hospital of Harvard Medical School in Boston, MA, USA and is a member of the OARSI Young Investigator Committee. Her research focuses on identifying genetic contributions to OA and the role of bone metabolism in OA pathogenesis. (18:42) Jeffrey Driban, PhD, ATC, CSCS, is an Assistant Professor in the Division of Rheumatology at Tufts University School of Medicine and a member of the Special and Scientific Staff at Tufts Medical Center in Boston, MA, USA. The goal of his research is to explore novel biochemical and imaging markers to gain a better understanding of osteoarthritis and potential disease subsets. Find out more on twitter at @jbdriban or at sportsmedres.org where you can find a link to his sports medicine podcast! (35:43) Chuck Ratzlaff, PhD, PT, FCAMT, was most recently an assistant professor at Arizona University College of Medicine in Tucson AZ, USA and now leads a multidisciplinary musculoskeletal clinic in his hometown of Vancouver, BC, Canada. His research interests include physical activity and joint health, quantitative assessment of MRI for clinical trials outcomes; and primary and secondary prevention of knee and hip OA. Join the conversation about the OAI on twitter using the hashtag #OAInitiative.

This episode highlights the recent GaitNET OA meeting. Researchers, clinicians, industry members, patient representatives, and advocacy groups from across Canada met to discuss how they could work together to make a greater impact on osteoarthritis-related healthcare.

Dr. Krysia Dziedzic, a qualified physiotherapist and professor at Keele University in Staffordshire, UK talks about patient engagement in research and facilitating knowledge mobilization to share research knowledge with a wide range of stakeholders. More information about Dr. Dziedzic’s research can be found at: https://www.keele.ac.uk/pchs/ Dr. Dziedzic mentioned the following resources: Lau et al. Achieving change in primary care--causes of the evidence to practice gap: systematic reviews of reviews. Implement Sci. 2016 Mar 22;11:40. doi: 10.1186/s13012-016-0396-4. Lau et al. Achieving change in primary care--effectiveness of strategies for improving implementation of complex interventions: systematic review of reviews. BMJ Open. 2015 Dec 23;5(12):e009993. doi: 10.1136/bmjopen-2015-009993. Nilsen P. Making sense of implementation theories, models and frameworks. Implement Sci. 2015;10:53.

Dr. Amanda Nelson, an assistant professor of medicine at the University of North Carolina at Chapel Hill in the United States, discusses imaging, the Walk with a Doc program, developing OARSI guidelines, and barriers preventing clinician scientists from staying in research. More information can be found at: Faculty website: https://www.med.unc.edu/tarc/people/amanda-e-nelson-md-mscr Walk With a Doc: http://walkwithadoc.org/ OA Action Alliance: http://oaaction.unc.edu/

Dr. Tom Appleton, a clinician-scientist and assistant professor of rheumatology and medicine at Western University in London, Ontario, Canada talks about having both a clinical career and a research career, OA phenotypes and the potential for patient-specific treatments, and his experience being part of the OARSI year in review for 2017. More information about Dr. Appleton’s research can be found at his website (coming soon): www.appletonlab.com or on twitter: @ctgappleton. The paper mentioned by Dr. Appleton on cell senescence and post-traumatic OA can be found at https://www.nature.com/nm/journal/v23/n6/full/nm.4324.html Remember to check out the new OARSI video at the bottom of the OARSI.org home page! You can also find OARSI on Facebook and Twitter: @OARSInews @OARSI_YI

Dr. Astephen Wilson, a professor of biomedical engineering at Dalhousie University in Halifax, Nova Scotia, Canada and co-director of the Dynamics of Human Motion Laboratory tells us about how she got started in her career in osteoarthritis research, gives some tips on productive collaboration and developing meaningful mentor-mentee relationships, and explains how principal component analysis can be used to interrogate both magnitude and temporal characteristics of gait waveform data.  More information about Dr. Astephen Wilson’s research can be found at: http://www.dal.ca/dohmlab @DOHMlab https://csb2018.ca/ @CSB2018    

Dr. Katz tells us about OARSI’s roles in promoting and facilitating OA research, his vision for the future of OARSI, and how his own research on treatment of meniscal tears fits into the broader goals of the organization. This episode was recorded at the 2017 OARSI World Congress on Osteoarthritis in Las Vegas! The OARSI guidelines mentioned by Dr. Katz can be found here https://www.oarsi.org/education/oarsi-guidelines The patient section of the OARSI website mentioned by Kerry can be found here https://www.oarsi.org/patients You can find out more about Dr. Katz’s research at http://www.oracore.org Lastly, the Osteoarthritis and Cartilage journal, which publishes abstracts from the annual OARSI conference, can be found at http://www.oarsijournal.com/

In this very first episode of Hey OA, host Kerry Costello gives an introduction to the podcast and a preview of what's to come. We have some great guests lined up for the next few episodes so get excited! For more OA research news, check out OARSI.org and follow us on social media @OARSInews, @OARSI_YI, and @heyoapodcast. If you have any questions or comments, tag us and use the hashtag #heyoapodcast. Thanks for listening!