Podcasts about Regenerative medicine

In this episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden interviews Dr. Alan Bauman, a leading expert in hair restoration. They discuss Dr. Bauman's journey into the field, the evolution of hair transplantation techniques, and the importance of scalp health and nutrition in hair restoration. Dr. Bauman shares insights on the advancements in Follicular Unit Extraction (FUE), the future of hair cloning, and the role of personalized regenerative treatments. The conversation emphasizes the significance of taking action against hair loss and the exciting developments in regenerative medicine.   For Audience ·       Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/ !    Takeaways ·       Dr. Bauman's journey into hair transplantation began unexpectedly. ·       The evolution of hair restoration techniques has significantly improved outcomes. ·       Follicular Unit Extraction (FUE) is a less invasive method for hair transplants. ·       Scalp health is crucial for successful hair restoration. ·       Nutritional status impacts hair growth and restoration. ·       Innovative treatments like exosomes are enhancing hair restoration results. ·       The future of hair cloning holds promise for unlimited hair supply. ·       Personalized regenerative treatments are becoming more accessible. ·       Legal changes are opening doors for regenerative medicine. ·       Patient engagement is key to successful hair restoration journeys.   Chapters 00:00 Introduction to Hair Restoration and Dr. Bauman's Journey 02:54 Evolution of Hair Transplant Techniques 05:38 The Shift to Follicular Unit Extraction (FUE) 08:27 Innovations in Hair Transplant Technology 11:18 Understanding Hair Follicle Health and Growth 14:22 Holistic Approaches to Hair Restoration 17:03 Nutritional Factors in Hair Health 18:27 Holistic Approaches to Hair Restoration 19:36 Scalp Health and Its Impact on Hair Growth 21:01 Optimizing Recovery with Nutrition and Therapies 22:22 Innovative Treatments for Scarring and Healing 23:39 Transformational Stories in Hair Restoration 24:46 The Concept of Living Young for a Lifetime 25:50 Advancements in Hair Cloning Technology 28:32 Personalized Regenerative Medicine in Hair Treatments 30:35 Combining Treatments for Enhanced Results 32:40 Regulatory Changes in Regenerative Medicine 36:06 Access to Innovative Treatments and Clinical Trials   To learn more about Dr. Alan Bauman: Email: alanjbauman@me.com Website: https://www.baumanmedical.com/ Facebook: https://www.facebook.com/alanjbauman LinkedIn: https://www.linkedin.com/in/alanjbauman/ Instagram:  https://www.instagram.com/DrAlanBauman/   Reach out to us at:    Website: https://gladdenlongevity.com/     Facebook: https://www.facebook.com/Gladdenlongevity/    Instagram: https://www.instagram.com/gladdenlongevity/?hl=en     LinkedIn: https://www.linkedin.com/company/gladdenlongevity    YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw 

Dr. Hoffman continues his conversation with Dr. Fawad Mian, a neurologist and regenerative medicine specialist, and author of “Getting to Pain Free: How to Make Your Body Stop Hurting So That You Can Start Living Again Without Drugs Or Surgery.”

Exploring Innovative Approaches to Pain Management with Dr. Fawad Mian, a neurologist and regenerative medicine specialist. He delves into the various forms of pain and the limitations of traditional treatments such as drugs and surgery. Dr. Mian shares his personal journey with chronic pain and his transition into regenerative medicine. The discussion covers alternative treatments like prolotherapy, platelet-rich plasma (PRP), and stem cell therapies, emphasizing their potential benefits and the importance of image guidance in their administration. They also touch upon lifestyle modifications and nutritional supplements for managing conditions like diabetic neuropathy and CIDP. Dr. Mian highlights the importance of a multifocal approach to pain management and offers insights from his book, “Getting to Pain Free: How to Make Your Body Stop Hurting So That You Can Start Living Again Without Drugs Or Surgery.”

Integrative oncologist Sean Devlin, DO, has over two decades of experience. He is challenging the conventional cancer care model by blending cutting-edge science with holistic healing. As a board-certified physician in Anti-Aging and Regenerative Medicine and a founder of the International Organization of Integrative Cancer Physicians, Dr. Devlin brings a unique perspective to treating cancer […]

Dr. Courtney Gillenwater is a US Navy veteran, global humanitarian, and pediatric specialist at Chara Health, Dr. Joy Kong's premier regenerative medicine clinic. With a background in traditional pediatrics and trauma medicine, Dr. Gillenwater transitioned into regenerative therapies after experiencing a rapid personal recovery using stem cells and exosomes. Now, she focuses on combining cutting-edge cellular treatments with comprehensive, integrative care to support children with autism, veterans with chronic injuries, and patients with complex inflammatory conditions.In this powerful episode, Dr. Joy Kong interviews Dr. Gillenwater about her unique path into regenerative medicine and the life-changing results she sees daily at Chara Health. From helping nonverbal children gain communication skills to aiding veterans with lung damage and patients on transplant lists, Dr. Gillenwater shares compelling case studies and clinical outcomes. The episode dives into how personalized stem cell protocols, micronutrient testing, and gut-brain optimization are transforming outcomes for children with autism spectrum disorders and adults facing serious health challenges.Visit My Clinic: Chara Health

Astellas is doubling down on gene therapy while others retreat. Richard Wilson, SVP at Astellas Gene Therapies, joins In Vivo to discuss why the company believes AAV technology will transform medicine despite current industry headwinds.

In this powerful episode of Converge Autism Radio, Dr. Stephanie Holmes speaks with Dr. Eric Weiss—surgeon, stem cell pioneer, and father to a son on the spectrum. Driven by personal experience, Dr. Weiss shares the emotional and scientific journey that led him to explore stem cell therapy for autism. From groundbreaking brain inflammation research to real-world results with his son, this conversation unpacks the potential of regenerative medicine to improve quality of life for autistic individuals. Listeners will learn about:The link between brain inflammation and autism symptomsHow umbilical cord stem cells are being used safely and effectivelyWhy stem cell therapy may open new doors for older autistic individualsThe personal breakthroughs that changed Dr. Weiss's career pathHow diet, gut health, and stem cells can support a holistic healing journeyWhether you're a parent, professional, or curious soul, this episode brings fresh insight and real hope.Dr. Eric Weiss is a board‑certified plastic surgeon and former U.S. Navy Commander who pivoted his career to regenerative medicine after his son Marston was diagnosed with autism and showed remarkable gains following umbilical cord stem cell therapy. Now serving as Medical Director of the Autism Program at Miami Stem Cell and founder of North Florida Stem Cells, he has treated over 400 children with data-driven protocols—reporting developmental improvements in about 65–70% of them—using MSCs, exosomes, MRI/EEG monitoring, and rigorous safety standards. He's also co‑author of Educating Marston and a frequent podcast guest, sharing both personal experience and emerging science in autism care.https://northfloridastemcells.com/

"I've been given life to affect life, and that's what I'm grateful for." - Mark Durante Mark Durante is the inspiring founder of Rize Up Medical, known for his pioneering work in regenerative medicine. After enduring a life-changing heart transplant and overcoming severe neuropathy pain through regenerative therapies, Mark dedicated himself to transforming patient care. His company, Rize Up Medical, empowers medical practitioners nationwide by incorporating cutting-edge regenerative therapies into their practices, revolutionizing patient outcomes and improving healthcare methodologies. Mark's compelling journey from a heart transplant patient to a leader in medical innovation highlights his commitment to improving lives through advanced medical practices. Episode Summary: In this captivating episode of "All My Health, There's Hope," host Jana Short engages with Mark Durante, founder of Rize Up Medical, in a heartfelt conversation about the power of regenerative medicine and his incredible personal journey. Mark shares his transformative experience from being a patient in need of a heart transplant to becoming a groundbreaking figure in regenerative therapies. His story is a testament to overcoming adversity and harnessing the potential of innovative medical treatments to improve the lives of patients nationwide. Mark Durante delves into the specifics of his journey with neuropathy and heart failure, shedding light on how regenerative medicine played a pivotal role in his recovery and eventual mission to help others. Through the Rize method, Mark has helped numerous practitioners implement regenerative solutions, addressing a range of conditions, from cardiac and neurological issues to orthopedic concerns. With a focus on wellness and sustainable health solutions, Mark's insights provide valuable knowledge on how the intersection of technology, medicine, and patient care can lead to life-changing outcomes. Notably, this episode underscores the importance of organ donation and how medical advancements can offer renewed hope for those facing debilitating health challenges. Key Takeaways: Mark Durante's transformative experience with a heart transplant and neuropathy led him to pioneer regenerative medicine advancements. Rize Up Medical aids practitioners in integrating cutting-edge regenerative therapies, enhancing patient care and practice growth. Regenerative medicine offers hope for numerous conditions, from neurological to orthopedic, showing promise in rejuvenating health. Advances in biologics and regenerative methods can positively impact aesthetics, wellness, and longevity, providing pathways to a better quality of life. The episode highlights the critical role of organ donation and how innovative medical treatments are pivotal in saving lives and offering hope. Resources www.rizeupmedical.com IG: @‌rizeupmedical FB: @‌rizeupmedical https://www.linkedin.com/in/mark-durante/ Get in touch with Jana and listen to more Podcasts: https://www.janashort.com/ Show Music ‘Hold On' by Amy Gerhartz https://www.amygerhartz.com/music. Get the Best Holistic Life Magazine Subscription! It is one of the fastest-growing independent magazines centered around holistic living. https://bestholisticlife.info/BestHolisticLifeMagazine Grab your gift today: https://bestholisticlife.info/BestHolisticLifeMagazine Connect with Jana Short: https://www.janashort.com/contact/

In this episode of the Aesthetic Injector Gang podcast, Brandon Mullen interviews Dr. Steven Sorr, a leading expert in regenerative medicine and wellness. They discuss Dr. Sorr's journey into naturopathic medicine, the importance of a holistic approach to hormone treatment, and the role of nutrition and exercise in achieving optimal health. The conversation also touches on the integration of AI in health and wellness, upcoming training in aesthetics, and the significance of peptides in regenerative medicine. Dr. Sorr emphasizes the need for a solid foundation in wellness and the importance of personalized treatment plans. Stalk Dr. Sorr @drstevensorr and his practice @sourceofhealth (www.mysourceofhealth.com)  Be sure to check out Moxie's amazing $1000 aesthetic provider training scholarship. Learn more: https://www.joinmoxie.com/scholarship    Find us:  Apple

What if the best diet for you isn't in a book or trending on social media—but instead, hidden in your own biology? In this episode, I sit down with functional medicine expert Dr. Anju Mathur to explore the world of personalized nutrition—a science-backed approach that tailors food and lifestyle choices to your unique body, genes, gut health, and more. We discuss: Why “one-size-fits-all” diets often fail How food sensitivities and nutrient imbalances affect autoimmune health The role of gut testing, genetic markers, and lab work in creating a personalized plan How to start listening to your body and create a nutrition strategy that actually works for you Whether you're struggling with autoimmune symptoms, chronic fatigue, or simply want to optimize your wellness, this conversation will empower you to take control of your health in a more personal way.

In this powerful episode of The Red Light Report, I'm joined by the brilliant Dr. Joy Kong — stem cell specialist, anti-aging physician, and founder of Chara Health and the American Academy of Integrative Cell Therapy.   We dive deep into: The science and clinical use of stem cell therapy Why umbilical cord-derived stem cells are safer and more potent than adult sources The truth about exosomes, cytokine storms, and foreign DNA fears How stem cells can transfer mitochondria, reverse tissue damage, and modulate immunity The importance of prepping your terrain with nutraceuticals, detox, and nitric oxide The role of red, green, and yellow light in stem cell activation and targeting Synergy between red light therapy and BioLight's enhanced methylene blue (BioBlue)   Whether you're exploring stem cells for longevity, healing, or neuroregeneration, this episode will reshape your understanding of what's truly possible.  

Elizabeth welcomes Dr. Tyna Moore for a straight-shooting conversation on one of the most talked-about topics in wellness right now: GLP-1s. A naturopathic physician, podcast host, and expert in regenerative medicine, Dr. Moore has been at the forefront of the metabolic health conversation for years, and she's not afraid to challenge the hype.In their chat, Elizabeth and Dr. Moore get into what GLP-1s actually do in the body beyond weight loss, from regulating blood sugar to calming inflammation and supporting brain health. They unpack the potential of microdosing peptides as a tool, not a quick fix, and talk through the lifestyle habits that make or break your results. They also explore the limitations and risks of using GLP-1s without context, and the role of strength training, sleep, and upping your protein intake in hormone health. Episodes Here Say Hi To Elizabeth and Purely Elizabeth: Website | InstagramDr. Tyna Moore: Website | The Doctor Tyna Show

In this episode of The Dr. Joy Kong Podcast, Dr. Joy speaks with Dr. Mike Jamshidi, a naturopathic doctor at Chara Health, about natural, hands-on approaches to pain relief beyond pills and surgery. Dr. Mike shares his journey from healing his own chronic health issues to helping patients address root causes of pain through bodywork, acupuncture, nutrition, and lifestyle changes.They also discuss advanced regenerative treatments like stem cells and exosomes, and Dr. Mike shares powerful stories of patients finding relief from severe conditions. This conversation highlights the power of working with the body's innate healing abilities for deeper, long-lasting recovery.--Additional Resources:Visit My Clinic: Chara Health

Regenerative medicine is redefining what's possible in healing and longevity, with stem cells, placental therapies, and cellular innovation leading the way. Dr. Dallas Kingsbury, Vice President of Regenerative Medicine at Fountain Life, dives into the therapies transforming how we age, recover, and perform. From orthopedic applications and wound care to tackling immune system decline and the root causes of aging, this conversation unpacks how stem cells and natural killer cells are powering the next evolution of healthcare. Learn how new legislation, rigorous science, and smart deployment are bringing cutting-edge treatments to the public—faster, safer, and more effectively than ever before.The information presented in Fully Alive is for educational and informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition or treatment and before making changes to your health regimen. Guests' opinions are their own and do not necessarily reflect those of the podcast host, production team, or sponsors.Love the show? Subscribe, rate, review, & share! https://www.shellpoint.org/podcast/The information presented in Fully Alive is for educational and informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition or treatment and before making changes to your health regimen. Guests' opinions are their own and do not necessarily reflect those of the podcast host, production team, or sponsors.

From the operating room to the research lab, fat is proving to be a game-changer in medicine and beauty. In this episode of The Technology of Beauty, Dr. Grant Stevens sits down with Marcille Pilkington, Owner & CEO of Tulip Medical Products, to explore how nanofat is revolutionizing both aesthetic treatments and regenerative care.Marcille shares the unexpected origin of Tulip—from its Parisian inspiration to its rise as a global leader in fat transfer technology. She dives into the mechanics and science behind nanofat, explaining how the company's innovations allow for delicate, cell-rich injections that are transforming results in facial rejuvenation, hair restoration, and even orthopedic repair.We also learn about Marcille's commitment to advancing regenerative science through the San Diego Academy of Regenerative Therapies and Science (SDARTS), a conference she founded to foster cross-specialty collaboration. With deep knowledge and an eye on the future, Marcille walks us through Tulip's evolution—and how it's helping clinicians harness the healing power of adipose tissue.» Apple Podcasts | https://podcasts.apple.com/us/podcast/technology-of-beauty/id1510898426» Spotify | https://open.spotify.com/show/0hEIiwccpZUUHuMhlyCOAm» Recent episodes | https://www.influxmarketing.com/technology-of-beauty/» Instagram | https://www.instagram.com/thetechnologyofbeauty/» LinkedIn | https://www.linkedin.com/company/the-technology-of-beauty/The Technology of Beauty is produced by Influx Marketing, The Digital Agency for Aesthetic Practices. https://www.influxmarketing.com/Want more aesthetic insights? Subscribe to Next Level Practices, the show where we discuss the ever-changing world of digital marketing and patient acquisition and bring you the latest ideas, strategies, and tactics to help you take your practice to the next level. https://www.influxmarketing.com/next-level-practices/

In this solo episode, Dr. Joy Kong breaks down the 5 biggest mistakes patients make when undergoing stem cell therapy—and how to avoid them to get the most out of your investment. Learn why using your own cells may not be ideal, the dangers of over-expanded lab-grown cells (especially from overseas clinics), and how lifestyle habits like overexertion, alcohol, and poor diet can sabotage your results. If you're considering regenerative therapy, this is essential listening for safer, more effective outcomes.Additional Resources:Visit My Clinic: Chara Health

“You have a superhuman hero inside you.” -Dr. AshIn this episode, Dr. Ash Kapoor joins Dr Espen and shares his extensive experience in regenerative medicine and the importance of addressing root causes of health issues rather than merely treating symptoms. He discusses the 12 hallmarks of aging, the benefits of fasting and nutrition, and the transformative power of breathwork and psychedelic-assisted therapy. Dr. Kapoor emphasizes the need for a paradigm shift in medicine towards a more holistic approach that incorporates nature and humanism, ultimately empowering individuals to take control of their health.About our guest:With over 30 years of experience in the NHS, Dr. Ash Kapoor is a pioneer in regenerative medicine, bio-aesthetics, and cellular longevity. He is the founder of Levitas Clinics, Levitas Dental, and Levitas Academy, and the creator of the groundbreaking NoMAD Programme and 8R Methodology.Dr. Ash is internationally recognised for his ability to blend precision science with holistic care and ancient wisdom, delivering measurable transformation through advanced diagnostics, personalised detox protocols, and longevity-focused therapies.

In this episode, I'm joined by Dr. Maribelle Verdiales, a pioneer in regenerative and integrative fertility medicine. We dive into groundbreaking therapies like intraovarian stem cell infusions, exosomes, and ovarian PRP, and how they can support fertility, especially for women over 40. Dr. Verdiales shares her personal journey from being a traditional OB/GYN to becoming a holistic healer, and she explains the science, safety, and logistics behind these emerging treatments. We also talk about the inspiration behind her work, what's possible in fertility care today, and why she's so passionate about empowering women to take charge of their reproductive health. In this episode, we cover: What stem cells, exosomes, and PRP are, and how they might support fertility Why some regenerative treatments are offered in Mexico and what patients should know Real-life stories of hope from Dr. Verdiales' patients How regenerative therapies are helping women over 40 reclaim fertility What's next in the future of holistic and regenerative fertility care ResourcesRead the full show notes on my website, including a transcript. Dr. Maribelle Verdiales website, and her book, The Healing Circle: A Story of Health, Science, and Love Do you have questions about IVF, and what to expect? Click here to join Dr. Aimee for The IVF Class. The next live class call is on Monday, July 14, 2025 at 4pm PST, where Dr. Aimee will explain IVF and there will be time to ask her your questions live on Zoom.   Dr. Aimee Eyvazzadeh is one of America's most well known fertility doctors. Her success rate at baby-making is what gives future parents hope when all hope is lost. She pioneered the TUSHY Method and BALLS Method to decrease your time to pregnancy. Learn more about the TUSHY Method and find a wealth of fertility resources at www.draimee.org. Other ways to connect: Subscribe to my YouTube channel for more fertility tips Join Egg Whisperer School Subscribe to the newsletter to get updates

Send us a textIn this episode of 'The Longevity Formula,' Dr. Brandon Crawford discusses the transformative potential of STEMREGEN®, a product designed to increase stem cell production. Joined by Christian Drapeau, a pioneer in the stem cell field, they explore how STEMREGEN® has shown promising results in improving conditions like autism, brain injuries, and chronic pain.The discussion covers the integration of STEMREGEN® with other clinical practices such as photobiomodulation, hyperbaric oxygen therapy, and PEMF, emphasizing the importance of increasing stem cells for better health outcomes. Dr. Crawford shares numerous success stories, including nonverbal kids starting to speak and severe cases showing significant improvement. The episode offers detailed guidance on how to introduce and utilize STEMREGEN® effectively in various therapeutic settings.Key TakeawaysSTEMREGEN® Impact on Health: Discover how increasing stem cells in the body with STEMREGEN® has shown significant improvements in conditions like autism, brain injuries, and chronic pain through better mobility, coordination, and verbalization.Complementing Therapies for Better Outcomes: Learn how combining STEMREGEN® with other therapies such as photobiomodulation, hyperbaric oxygen therapy, and PEMF enhances treatment effectiveness, leading to faster and more substantial patient recoveries.Patient Education and Compliance: Understand the importance of educating patients about the benefits of increased stem cell production and how committing to a three-month trial period can significantly improve their health outcomes.Clinical Success Stories: Hear about remarkable cases like Millie, a child with a severe brain disorder, who showcased significant improvements in motor functions and vocalization with the use of STEMREGEN®, demonstrating its potential in severe medical conditions.Optimizing Dosage for Maximum Benefits Learn the benefits of adapting STEMREGEN® dosage, such as taking it more frequently throughout the day, to maximize therapeutic effects and improve repair mechanisms in conditions requiring acute attention.ResourcesSTEMREGEN®: stemregen.co/crawfordProducts 528 Innovations Lasers NeuroSolution Full Spectrum CBD NeuroSolution Broad Spectrum CBD NeuroSolution StimPod Learn MoreFor more information, resources, and podcast episodes, visit https://tinyurl.com/3ppwdfpm

On this special episode of the Architect of Resilience Podcast, host Chris Duffin welcomes back Dr. Rahul Desai, a regenerative musculoskeletal radiologist and expert in innovative therapies for joint and spine health. Originally recorded during a private member community session, this conversation dives deep into the cutting-edge world of red and near-infrared light therapy—otherwise known as photobiomodulation. Dr. Desai shares his extensive experience using platelet-rich plasma (PRP), bone marrow, and fat-derived treatments to help patients heal without surgery, and he unpacks the science and safety of red light therapy for tissue regeneration, pain relief, and overall wellness. The discussion is packed with direct audience questions, revealing practical insights on treatment timing, optimal dosing, systemic versus local effects, and the latest research on using light therapy for everything from injury recovery to anti-aging and sleep.   This episode of the ARCHITECT of RESILIENCE podcast is available on Apple, Spotify & YouTube, and is sponsored by  @marekhealth : Performance. Longevity. Optimization.

Summary In this episode of the Pain Exam Podcast, Dr. David Rosenblum provides a comprehensive review of herpes zoster and postherpetic neuralgia (PHN), focusing on pathophysiology, diagnosis, and treatment options. Dr. Rosenblum explains that postherpetic neuralgia affects approximately 25% of patients with acute herpes zoster, causing debilitating unilateral chronic pain in one or more dermatomes. He discusses the three phases of herpes zoster: acute (up to 30 days), subacute (up to 3 months), and postherpetic neuralgia (pain continuing beyond 3 months). Dr. Rosenblum identifies risk factors for developing PHN, including older age, female sex, immunosuppression, prodromal pain, severe rash, and greater acute pain severity. He details the pathophysiology involving peripheral and central sensitization, and explains different phenotypes of PHN that can guide treatment approaches. For treatment, Dr. Rosenblum reviews various options including antiviral medications (which should be started within 72 hours of onset), corticosteroids, opioids, antidepressants (particularly tricyclics and SNRIs), antiepileptics (gabapentin and pregabalin), topical agents (lidocaine and capsaicin), and interventional procedures such as epidural injections and pulsed radiofrequency. He emphasizes that prevention through vaccination with Shingrix is highly effective, with 97% effectiveness in preventing herpes zoster in patients 50-69 years old and 89% effectiveness in those over 70. Dr. Rosenblum mentions that he's currently treating a patient with trigeminal postherpetic neuralgia and is considering a topical sphenopalatine ganglion block as a minimally invasive intervention before attempting more invasive procedures. Chapters Introduction to the Pain Exam Podcast and Topic Overview Dr. David Rosenblum introduces the Pain Exam Podcast, mentioning that it covers painful disorders, alternative treatments, and practice management. He explains that this episode focuses on herpes zoster and postherpetic neuralgia as board preparation for fellows starting their programs, with ABA boards coming up in September. Dr. Rosenblum notes that he's not only preparing listeners for boards but also seeking the latest information to help treat his own patients with this notoriously difficult disease. Upcoming Conferences and Educational Opportunities Dr. Rosenblum announces several upcoming conferences including Aspen in July, Pain Week in September, and events with NYSIP and the Latin American Pain Society. He mentions he'll be teaching ultrasound and regenerative medicine at these events. Dr. Rosenblum invites listeners to sign up at nrappain.org to access a community discussing regenerative medicine, ultrasound-guided pain medicine, regional anesthesia, and board preparation. He also offers ultrasound training in New York and elsewhere, with upcoming sessions in Manhattan on July 12th and October 4th, plus private shadowing opportunities. Overview of Postherpetic Neuralgia Dr. Rosenblum defines postherpetic neuralgia as typically a unilateral chronic pain in one or more dermatomes after acute herpes zoster infection. He states that the incidence of acute herpes zoster ranges between 3-5 patients per thousand person-years, and one in four patients with acute herpes zoster-related pain will transition into postherpetic neuralgia. Dr. Rosenblum emphasizes that while this condition won't kill patients, it can be extremely debilitating and significantly reduce quality of life. Treatment Options Overview Dr. Rosenblum reviews treatment options according to the WHO pain ladder, including tricyclics like nortriptyline and antiepileptic drugs such as gabapentin. He explains that if pain is not significantly reduced, interventional treatments like epidural injections with local anesthetics and corticosteroids or pulsed radiofrequency of the dorsal root ganglion are options. For postherpetic neuralgia specifically, Dr. Rosenblum notes that preferred treatments include transdermal capsaicin, lidocaine, or oral drugs such as antidepressants or antiepileptics. Phases of Herpes Zoster and Definitions Dr. Rosenblum outlines the three phases during herpes zoster reactivation: acute herpes zoster-related pain (lasting maximum 30 days), subacute herpes zoster-related pain (pain after healing of vesicles but disappearing within 3 months), and postherpetic neuralgia (typically defined as pain continuing after 3 months). He mentions that acute herpes zoster pain often begins with prodromal pain starting a few days before the appearance of the rash. Incidence and Risk Factors Dr. Rosenblum states that the incidence of herpes zoster ranges between 3-5 patients per 1,000 person-years, with approximately 5-30% of cases leading to postherpetic neuralgia. He identifies risk factors including older age, female sex, immunosuppression, prodromal pain, severe rash, and greater acute pain severity. Dr. Rosenblum describes the clinical manifestations as a mosaic of somatosensory symptoms including burning, deep aching pain, tingling, itching, stabbing, often associated with tactile and cold allodynia. Impact on Quality of Life Dr. Rosenblum emphasizes that postherpetic neuralgia can be debilitating, impacting both physical and emotional functioning and causing decreased quality of life. He notes that it leads to fatigue, insomnia, depression, anorexia, anxiety, and emotional distress. Dr. Rosenblum stresses the importance of exploring methods for prevention of postherpetic neuralgia and optimizing pain treatment for both subacute herpes zoster-related pain and postherpetic neuralgia. Literature Review and Pathophysiology Dr. Rosenblum mentions that he's discussing a literature review from 2024 that updates previous practical guidelines published in 2011. He explains the pathophysiology of postherpetic neuralgia, which involves sensitization of peripheral and sensory nerves from damage. Dr. Rosenblum describes how inflammatory mediators reduce the stimulus threshold of nociceptors and increase responsiveness, resulting in pathological spontaneous discharges, lower thresholds for thermal and mechanical stimuli, and hyperalgesia. Central Sensitization and Nerve Damage Dr. Rosenblum explains that central sensitization results from peripheral nociceptor hyperactivity leading to plastic changes in the central nervous system, involving amplification of pain signals and reduced inhibition. He describes how nerve damage in postherpetic neuralgia patients results from neuronal death due to severe inflammatory stimuli or secondary to neuronal swelling. Dr. Rosenblum notes that motor defects occur in 0.05% of patients with herpes zoster, observed as abdominal pseudohernias or motor weakness of limbs limited to the affected myotome. Different Phenotypes and Classification Dr. Rosenblum discusses different phenotypes of postherpetic neuralgia and how phenotyping can determine treatment. He explains that there are several ways to classify the phenotypes, with one categorizing patients into three subtypes: sensory loss (most common), thermal gain, and thermal loss with mechanical gain. Dr. Rosenblum describes the mechanistic categorization, including the irritable nociceptive phenotype characterized by preserved sensation, profound dynamic mechanical allodynia, reduced pressure pain threshold, and relief with local anesthetic infiltration. Deafferentation Phenotype Dr. Rosenblum explains that a deafferentation phenotype may arise from destruction of neurons by the virus in the dorsal root ganglion. This phenotype is characterized by sensory loss, including thermal and vibratory sensation without prominent thermal allodynia. He notes that mechanical allodynia can occur secondary to A-beta fibers activating spinothalamic pathways (known as phenotypic switches), along with pressure hyperalgesia and temporal summation suggesting central sensitization. Dr. Rosenblum mentions that in one study, this phenotype was present in 10.8% of individuals, and for those with deafferentation pain, gabapentinoids, antidepressants, and neuromodulatory therapies like repetitive transcranial magnetic stimulation may be beneficial. Diagnosis and Physical Examination Dr. Rosenblum discusses the diagnosis of herpes zoster and postherpetic neuralgia, emphasizing the importance of physical examination. He explains that diagnosis is based on the rash, redness, papules, and vesicles in the painful dermatomes, with healing vesicles showing crust formation. Dr. Rosenblum notes that the rash is generally unilateral and does not cross the midline of the body. In postherpetic neuralgia patients, he mentions that scarring, hyper or hypopigmentation is often visible, with allodynia present in 45-75% of affected patients. Sensory Testing and Assessment Dr. Rosenblum explains that in patients with postherpetic neuralgia, a mosaic of somatosensory alterations can occur, manifesting as hyperalgesia, allodynia, and sensory loss. These can be quantified by quantitative sensory testing, which assesses somatosensory functions, dermal detection thresholds for perception of cold, warmth, and paradoxical heat sensations. He notes that testing can provide clues regarding underlying mechanisms of pain, impaired conditioned pain modulation, temporal summation suggesting central sensitization, and information about the type of nerve damage and surviving afferent neurons. Prevention Through Vaccination Dr. Rosenblum discusses prevention of acute herpes zoster through vaccination, noting that the risk increases with reduced immunity. He highlights studies evaluating Shingrix, a vaccine for herpes zoster, which showed 97% effectiveness in preventing herpes zoster in patients 50-69 years old with healthy immune systems and 89% effectiveness in patients over 70. Dr. Rosenblum states that Shingrix is 89-91% effective in preventing postherpetic neuralgia development in patients with healthy immune systems and 68-91% effective in those with weakened or underlying conditions. Treatment Objectives Dr. Rosenblum outlines the treatment objectives for herpes zoster and postherpetic neuralgia. For acute herpes zoster, objectives include relieving pain, reducing severity and duration of pain, accelerating recovery of epidermal defects, and preventing secondary infections. For postherpetic neuralgia, the objectives are pain alleviation and improved quality of life. Dr. Rosenblum lists available treatments including psychotherapy, opiates, antidepressants, antiepileptics, NMDA antagonists, topical agents, and interventional treatments such as epidurals, pulsed radiofrequency, nerve blocks, and spinal cord stimulation. Antiviral Medications Dr. Rosenblum emphasizes that antiviral drugs should be started within 72 hours of clinical onset, mentioning famciclovir, valacyclovir, and acyclovir. He notes there is no evidence for effectiveness after 72 hours in patients with uncomplicated herpes zoster. Dr. Rosenblum provides dosing information: for immunocompetent patients, famciclovir 500mg and valacyclovir 1000mg three times daily for seven days; for immunocompromised patients, famciclovir 1000mg three times daily for 10 days, while acyclovir should be given IV in the immunocompromised. Benefits of Antiviral Therapy Dr. Rosenblum explains that antiviral medication accelerates the disappearance of vesicles and crusts, promotes healing of skin lesions, and prevents new lesions from forming. By inhibiting viral replication, he notes that antiviral therapy likely reduces nerve damage, resulting in reduced incidence of postherpetic neuralgia, and should be started as soon as possible. Corticosteroids and Opioids Dr. Rosenblum discusses the use of corticosteroids, noting that when added to antiviral medications, they may reduce the severity of acute herpes zoster-related pain, though increased healing of skin lesions was not observed in one study. He mentions that a Cochrane review found oral corticosteroids ineffective in preventing postherpetic neuralgia. Regarding opioids, Dr. Rosenblum states they are commonly used alongside antivirals for controlling acute herpes zoster pain, with tramadol having a number needed to treat (NNT) of 4.7 and strong opioids having an NNT of 4.3 for 50% pain reduction. Methadone and Antidepressants Dr. Rosenblum discusses methadone as an NMDA receptor antagonist used in acute and chronic pain management, though he notes there are no randomized controlled trials determining its efficacy in acute herpes zoster pain or postherpetic neuralgia. He explains that methadone can modulate pain stimuli by inhibiting the uptake of norepinephrine and serotonin, resulting in decreased development of hyperalgesia and opioid tolerance, but has side effects including constipation, nausea, sedation, and QT prolongation that can trigger torsades de pointes. Dr. Rosenblum identifies antidepressants as first-line therapy for postherpetic neuralgia, including tricyclics and SNRIs, with tricyclics having an NNT of 3 and SNRIs an NNT of 6.4 for 50% pain reduction. Antiepileptics and Pharmacological Treatment Summary Dr. Rosenblum discusses antiepileptics like gabapentin and pregabalin for postherpetic neuralgia. He cites two trials measuring gabapentin's effect, concluding it was effective compared to placebo with a pooled NNT of 4.4, while pregabalin had an NNT of 4.9. Dr. Rosenblum summarizes that pharmacological treatment is well established for subacute herpes zoster pain, though new high-quality evidence has been lacking since the last update in 2011. Topical Agents Dr. Rosenblum discusses local anesthetic topical agents including lidocaine and capsaicin creams and patches. He notes that 8% capsaicin provided significant pain reduction during 2-8 weeks, while 5% lidocaine patches provided moderate pain relief after eight weeks of treatment. Dr. Rosenblum also mentions acute herpes zoster intracutaneous injections, citing a study where single intracutaneous injection with methylprednisolone combined with ropivacaine versus saline alone showed significant difference in VAS score at 1 and 4 weeks post-intervention favoring the intervention group. Intracutaneous Injections Dr. Rosenblum discusses the effect of repetitive intracutaneous injections with ropivacaine and methylprednisolone every 48 hours for one week. He cites a randomized control trial comparing antivirals plus analgesics to antivirals plus analgesics and repeat injections, finding the intervention group had significantly shorter duration of pain, lower VAS scores, and lower incidence of postherpetic neuralgia (6.4% vs 28% at 3 months). Dr. Rosenblum notes that a potential side effect of cutaneous methylprednisolone injection is fat atrophy, though this wasn't reported in the study. Summary of Local Anesthetics Dr. Rosenblum summarizes that there are no new studies reporting the efficacy of capsaicin 8% for postherpetic neuralgia, but it remains widely used in clinical practice and is approved in several countries. He notes that lidocaine patches can reduce pain intensity in patients with postherpetic neuralgia but may be more beneficial in patients with allodynia. Dr. Rosenblum adds that intracutaneous injections may be helpful for short periods, while repetitive injections with local anesthetics may reduce VAS scores for up to six months but can cause subcutaneous fat atrophy. Interventional Treatments: Epidural and Paravertebral Injections Dr. Rosenblum discusses interventional treatments, noting that previous guidelines found epidural injection with corticosteroids and local anesthetic as add-on therapy superior to standard care alone for up to one month in managing acute herpes zoster pain. He mentions a randomized controlled trial showing no difference between interlaminar and transforaminal epidural steroid injections for up to three months after the procedure. Dr. Rosenblum adds that previous guidelines reported high-quality evidence that paravertebral injections of corticosteroids or local anesthetic reduces pain in the active phase of herpes zoster. Comparative Studies on Injection Approaches Dr. Rosenblum discusses a trial comparing efficacy of repetitive paravertebral blocks with ropivacaine versus dexmedetomidine to prevent postherpetic neuralgia, which showed significantly lower incidence of zoster-related pain one month after therapy in the dexmedetomidine group, with effects still significant at three months. He also mentions a study comparing steroid injections administered via interlaminar versus transforaminal approaches, finding both groups had significantly lower VAS scores at 1 and 3 months follow-up compared to baseline, though this could align with the natural course of herpes zoster. Timing of Interventions and Continuous Epidural Blockade Dr. Rosenblum cites a retrospective study showing that transforaminal epidural injections administered for acute herpes zoster-related pain were associated with significantly shorter time to pain relief compared to those performed in the subacute phase. He also mentions a randomized controlled trial finding that continuous epidural blockade combined with opioids and gabapentin reduced NRS pain scores more than analgesic drug treatments alone during three-day follow-up, though both studies were low-quality. Interventions for Postherpetic Neuralgia Dr. Rosenblum discusses interventions specifically for postherpetic neuralgia, citing a small randomized controlled trial that demonstrated decreased NRS pain scores six months post-treatment for repeat versus single epidural steroid injections (15mg vs 5mg dexamethasone) administered over 24 days. The trial also found increased likelihood of complete remission during 6-month follow-up in the group receiving repeat epidural dexamethasone, though this was low-quality evidence. Summary of Epidural and Paravertebral Injections Dr. Rosenblum summarizes that epidural or paravertebral injections of local anesthetic and/or glucocorticoids could be considered in treating acute herpes zoster-related pain. For subacute postherpetic neuralgia pain, he notes low-quality evidence supporting epidural injections, while for postherpetic neuralgia, evidence supports continuous epidural infusion, though also of low quality. Dr. Rosenblum emphasizes that none of the included studies for postherpetic neuralgia investigating epidural or paravertebral injections resulted in decreased pain compared to standard therapy. Pulsed Radiofrequency (PRF) Evidence Dr. Rosenblum discusses pulsed radiofrequency (PRF), noting that previous guidelines indicated moderate quality evidence that PRF of the intercostal nerve reduces pain for 6 months in patients with postherpetic neuralgia, and very low-quality evidence that PRF to the dorsal root ganglion (DRG) reduces pain for 6 months. He mentions that multiple studies have been published since then assessing PRF efficacy. PRF Studies for Acute Herpes Zoster Dr. Rosenblum discusses a randomized controlled trial with 60 patients comparing high-voltage bipolar PRF of the cervical sympathetic chain versus sham, with treatment repeated after three days in both groups. He reports that VAS scores in the PRF group at each post-interventional point (1 day, 2 days, 1 month, 2 months, 3 months) were significantly lower than in the sham group, and at 3 months, the incidence of postherpetic neuralgia was 16.7% in the PRF group compared to 40% in the sham group. PRF for Trigeminal Neuralgia Dr. Rosenblum cites another randomized controlled trial evaluating high-voltage long-duration PRF of the Gasserian ganglion in 96 patients with subacute herpes-related trigeminal neuralgia, which found decreased VAS pain scores at all post-interventional time points (3, 7, 14 days and 1, 3, and 6 months) compared to the sham group. He also mentions a randomized comparative effectiveness study in 120 patients with subacute trigeminal herpes zoster, comparing a single application of high-voltage PRF to the Gasserian ganglion versus three cycles of conventional PRF treatment, finding significantly lower mean VAS pain scores for up to six months in the high-voltage PRF group. PRF Compared to Other Interventions Dr. Rosenblum discusses a randomized controlled trial comparing PRF to short-term spinal cord stimulation, which found decreased pain and improved 36-item short-form health survey scores in both groups at six months. He also mentions a randomized controlled trial in 72 patients where PRF of spinal nerves or peripheral branches of cranial nerves combined with five-day infusion of IV lidocaine resulted in greater pain reduction, less rescue analgesia, and reduced inflammatory cytokines at two months compared to PRF with saline infusions. Dr. Rosenblum notes a major limitation of this study was not accounting for the high natural recovery rate. Summary of PRF and Final Recommendations Dr. Rosenblum summarizes that PRF provides significant pain relief lasting over three months in patients with subacute herpes zoster and postherpetic neuralgia. He notes that since few studies have compared PRF versus sham, it's not possible to calculate an accurate number needed to treat. Dr. Rosenblum mentions there are no comparative studies comparing PRF to the intercostal nerves versus PRF of the DRG, but both preclinical and clinical studies suggest superiority of the DRG approach. He adds that evidence for spinal cord stimulation for postherpetic neuralgia is of low quality, and more research is needed given its invasive nature. Sympathetic Blocks and Conclusion Dr. Rosenblum notes there is low-quality evidence for using sympathetic blocks to treat acute herpes zoster-related pain, but no evidence for their use in postherpetic neuralgia. He mentions that risks of treatment with intrathecal methylprednisolone are unclear and therefore not recommended. Dr. Rosenblum concludes by praising the comprehensive article he's been discussing and mentions it provides insight for treating his patients, including a recent case of trigeminal postherpetic neuralgia. Personal Clinical Approach and Closing Dr. Rosenblum shares that he doesn't currently perform PRF in his practice, partly because it's not standard of care and not well reimbursed, creating barriers to implementation. However, he notes that PRF is a very safe procedure as it doesn't involve burning tissue. For his patient with trigeminal neuralgia pain, Dr. Rosenblum plans to try a topical sphenopalatine ganglion block as the least invasive intervention before considering injecting the trigeminal nerves at the foramen, in addition to pharmacotherapy. He concludes by thanking listeners, encouraging them to check the show notes and links, mentioning institutional memberships and shadowing opportunities, and asking listeners to rate and share the podcast. Q&A No Q&A session in this lecture Pain Management Board Prep   Ultrasound Training REGISTER TODAY!   Create an Account and get Free Access to the PainExam- NRAP Academy Community Highlights     David Rosenblum, MD, currently serves as the Director of Pain Management at Maimonides Medical Center and AABP Integrative Pain Care.  As a member of the Department of Anesthesiology, he is involved in teaching, research, CME activities, and was key faculty in developing the anesthesiology residency's regional anesthesia block rotation, as well as institutional wide acute and chronic pain management protocols to ensure safe and effective pain management. He currently is a managing partner in a multi-physician private pain practice, AABP Integrative Pain Care, located in Brooklyn, NY. He is one of the earliest interventional pain physicians to integrate ultrasound guidance to improve the safety and accuracy of interventional pain procedures.   Awards New York Magazine: Top Doctors: 2016, 2017, 2018, 2021, 2022, 2023, 2024, 2025 Schneps Media: 2015, 2016, 2017, 2019, 2020 Top Doctors New York Metro Area (digital guide): 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023 2025 Schneps Media - Brooklyn Courier Life: 2021, 2022, 2023   Dr. Rosenblum written several book chapters on Peripheral Neuromodulation, Radiofrequency Ablation, and Pharmacology.  He has published numerous noteworthy articles and most recently is developing the ASIPP Guidelines for Peripheral Neuromodulation in the treatment of chronic pain. He has been named several times in NY Magazine's Best Pain Management Doctor List, Nassau County's Best Pain Physician, has appeared on NY1 News, and has made several appearances on XM Radio's Doctor Talk. He currently is lecturing on a national and international level and has partnered with the American Society of Interventional Pain Physicians (ASIPP), American Society of Pain and Neuroscience (ASPN), IASP Mexican Chapter, Eastern Pain Association (EPA), the North American Neuromodulation Society (NANS), World Academy of Pain Medicine United, as well as various other organizations, to support educational events and develop new courses. Since 2008, he has helped over 3000 physicians pass the Pain Management Boards, and has been at the forefront of utilizing ultrasound guidance to perform pain procedures.  He now hosts the PainExam podcast, AnesthesiaExam Podcast, PMRExam Podcasts and uses this platform to promote the safe and effective use of ultrasound in the performance of various procedures such as Peripheral Nerve Stimulation, Caudal Epidurals, Selective Nerve Root Blocks, Cluneal Nerve Blocks, Ganglion impar Blocks, Stellate Ganglion Blocks, Brachial Plexus Blocks, Joint Injections and much more!   Doctor Rosenblum created the NRAP (Neuromodulation Regional Anesthesia and Pain) Academy  and travels to teach various courses focused on Pain Medicine, Regenerative Medicine, Ultrasound Guided Pain Procedures and Regional Anesthesia Techniques.  Dr. Rosenblum is persistent when it comes to eliminating pain and has gained a reputation among his patients for thinking "outside the box" and implements ultrasound guidance to deposit medications, biologics (PRP, Bone Marrow Aspirate, etc.) and Peripheral Nerve Stimulators near pain generators. He is currently treating patients in his great neck and Brooklyn office.  For an appointment go to AABPpain.com or call Brooklyn     718 436 7246 Reference Adriaansen, E. J., Jacobs, J. G., Vernooij, L. M., van Wijck, A. J., Cohen, S. P., Huygen, F. J., & Rijsdijk, M. (2025). 8. Herpes zoster and post herpetic neuralgia. Pain Practice, 25(1), e13423.

Summary In this episode of the Pain Exam Podcast, Dr. David Rosenblum provides a comprehensive review of herpes zoster and postherpetic neuralgia (PHN), focusing on pathophysiology, diagnosis, and treatment options. Dr. Rosenblum explains that postherpetic neuralgia affects approximately 25% of patients with acute herpes zoster, causing debilitating unilateral chronic pain in one or more dermatomes. He discusses the three phases of herpes zoster: acute (up to 30 days), subacute (up to 3 months), and postherpetic neuralgia (pain continuing beyond 3 months). Dr. Rosenblum identifies risk factors for developing PHN, including older age, female sex, immunosuppression, prodromal pain, severe rash, and greater acute pain severity. He details the pathophysiology involving peripheral and central sensitization, and explains different phenotypes of PHN that can guide treatment approaches. For treatment, Dr. Rosenblum reviews various options including antiviral medications (which should be started within 72 hours of onset), corticosteroids, opioids, antidepressants (particularly tricyclics and SNRIs), antiepileptics (gabapentin and pregabalin), topical agents (lidocaine and capsaicin), and interventional procedures such as epidural injections and pulsed radiofrequency. He emphasizes that prevention through vaccination with Shingrix is highly effective, with 97% effectiveness in preventing herpes zoster in patients 50-69 years old and 89% effectiveness in those over 70. Dr. Rosenblum mentions that he's currently treating a patient with trigeminal postherpetic neuralgia and is considering a topical sphenopalatine ganglion block as a minimally invasive intervention before attempting more invasive procedures. Chapters Introduction to the Pain Exam Podcast and Topic Overview Dr. David Rosenblum introduces the Pain Exam Podcast, mentioning that it covers painful disorders, alternative treatments, and practice management. He explains that this episode focuses on herpes zoster and postherpetic neuralgia as board preparation for fellows starting their programs, with ABA boards coming up in September. Dr. Rosenblum notes that he's not only preparing listeners for boards but also seeking the latest information to help treat his own patients with this notoriously difficult disease. Upcoming Conferences and Educational Opportunities Dr. Rosenblum announces several upcoming conferences including Aspen in July, Pain Week in September, and events with NYSIP and the Latin American Pain Society. He mentions he'll be teaching ultrasound and regenerative medicine at these events. Dr. Rosenblum invites listeners to sign up at nrappain.org to access a community discussing regenerative medicine, ultrasound-guided pain medicine, regional anesthesia, and board preparation. He also offers ultrasound training in New York and elsewhere, with upcoming sessions in Manhattan on July 12th and October 4th, plus private shadowing opportunities. Overview of Postherpetic Neuralgia Dr. Rosenblum defines postherpetic neuralgia as typically a unilateral chronic pain in one or more dermatomes after acute herpes zoster infection. He states that the incidence of acute herpes zoster ranges between 3-5 patients per thousand person-years, and one in four patients with acute herpes zoster-related pain will transition into postherpetic neuralgia. Dr. Rosenblum emphasizes that while this condition won't kill patients, it can be extremely debilitating and significantly reduce quality of life. Treatment Options Overview Dr. Rosenblum reviews treatment options according to the WHO pain ladder, including tricyclics like nortriptyline and antiepileptic drugs such as gabapentin. He explains that if pain is not significantly reduced, interventional treatments like epidural injections with local anesthetics and corticosteroids or pulsed radiofrequency of the dorsal root ganglion are options. For postherpetic neuralgia specifically, Dr. Rosenblum notes that preferred treatments include transdermal capsaicin, lidocaine, or oral drugs such as antidepressants or antiepileptics. Phases of Herpes Zoster and Definitions Dr. Rosenblum outlines the three phases during herpes zoster reactivation: acute herpes zoster-related pain (lasting maximum 30 days), subacute herpes zoster-related pain (pain after healing of vesicles but disappearing within 3 months), and postherpetic neuralgia (typically defined as pain continuing after 3 months). He mentions that acute herpes zoster pain often begins with prodromal pain starting a few days before the appearance of the rash. Incidence and Risk Factors Dr. Rosenblum states that the incidence of herpes zoster ranges between 3-5 patients per 1,000 person-years, with approximately 5-30% of cases leading to postherpetic neuralgia. He identifies risk factors including older age, female sex, immunosuppression, prodromal pain, severe rash, and greater acute pain severity. Dr. Rosenblum describes the clinical manifestations as a mosaic of somatosensory symptoms including burning, deep aching pain, tingling, itching, stabbing, often associated with tactile and cold allodynia. Impact on Quality of Life Dr. Rosenblum emphasizes that postherpetic neuralgia can be debilitating, impacting both physical and emotional functioning and causing decreased quality of life. He notes that it leads to fatigue, insomnia, depression, anorexia, anxiety, and emotional distress. Dr. Rosenblum stresses the importance of exploring methods for prevention of postherpetic neuralgia and optimizing pain treatment for both subacute herpes zoster-related pain and postherpetic neuralgia. Literature Review and Pathophysiology Dr. Rosenblum mentions that he's discussing a literature review from 2024 that updates previous practical guidelines published in 2011. He explains the pathophysiology of postherpetic neuralgia, which involves sensitization of peripheral and sensory nerves from damage. Dr. Rosenblum describes how inflammatory mediators reduce the stimulus threshold of nociceptors and increase responsiveness, resulting in pathological spontaneous discharges, lower thresholds for thermal and mechanical stimuli, and hyperalgesia. Central Sensitization and Nerve Damage Dr. Rosenblum explains that central sensitization results from peripheral nociceptor hyperactivity leading to plastic changes in the central nervous system, involving amplification of pain signals and reduced inhibition. He describes how nerve damage in postherpetic neuralgia patients results from neuronal death due to severe inflammatory stimuli or secondary to neuronal swelling. Dr. Rosenblum notes that motor defects occur in 0.05% of patients with herpes zoster, observed as abdominal pseudohernias or motor weakness of limbs limited to the affected myotome. Different Phenotypes and Classification Dr. Rosenblum discusses different phenotypes of postherpetic neuralgia and how phenotyping can determine treatment. He explains that there are several ways to classify the phenotypes, with one categorizing patients into three subtypes: sensory loss (most common), thermal gain, and thermal loss with mechanical gain. Dr. Rosenblum describes the mechanistic categorization, including the irritable nociceptive phenotype characterized by preserved sensation, profound dynamic mechanical allodynia, reduced pressure pain threshold, and relief with local anesthetic infiltration. Deafferentation Phenotype Dr. Rosenblum explains that a deafferentation phenotype may arise from destruction of neurons by the virus in the dorsal root ganglion. This phenotype is characterized by sensory loss, including thermal and vibratory sensation without prominent thermal allodynia. He notes that mechanical allodynia can occur secondary to A-beta fibers activating spinothalamic pathways (known as phenotypic switches), along with pressure hyperalgesia and temporal summation suggesting central sensitization. Dr. Rosenblum mentions that in one study, this phenotype was present in 10.8% of individuals, and for those with deafferentation pain, gabapentinoids, antidepressants, and neuromodulatory therapies like repetitive transcranial magnetic stimulation may be beneficial. Diagnosis and Physical Examination Dr. Rosenblum discusses the diagnosis of herpes zoster and postherpetic neuralgia, emphasizing the importance of physical examination. He explains that diagnosis is based on the rash, redness, papules, and vesicles in the painful dermatomes, with healing vesicles showing crust formation. Dr. Rosenblum notes that the rash is generally unilateral and does not cross the midline of the body. In postherpetic neuralgia patients, he mentions that scarring, hyper or hypopigmentation is often visible, with allodynia present in 45-75% of affected patients. Sensory Testing and Assessment Dr. Rosenblum explains that in patients with postherpetic neuralgia, a mosaic of somatosensory alterations can occur, manifesting as hyperalgesia, allodynia, and sensory loss. These can be quantified by quantitative sensory testing, which assesses somatosensory functions, dermal detection thresholds for perception of cold, warmth, and paradoxical heat sensations. He notes that testing can provide clues regarding underlying mechanisms of pain, impaired conditioned pain modulation, temporal summation suggesting central sensitization, and information about the type of nerve damage and surviving afferent neurons. Prevention Through Vaccination Dr. Rosenblum discusses prevention of acute herpes zoster through vaccination, noting that the risk increases with reduced immunity. He highlights studies evaluating Shingrix, a vaccine for herpes zoster, which showed 97% effectiveness in preventing herpes zoster in patients 50-69 years old with healthy immune systems and 89% effectiveness in patients over 70. Dr. Rosenblum states that Shingrix is 89-91% effective in preventing postherpetic neuralgia development in patients with healthy immune systems and 68-91% effective in those with weakened or underlying conditions. Treatment Objectives Dr. Rosenblum outlines the treatment objectives for herpes zoster and postherpetic neuralgia. For acute herpes zoster, objectives include relieving pain, reducing severity and duration of pain, accelerating recovery of epidermal defects, and preventing secondary infections. For postherpetic neuralgia, the objectives are pain alleviation and improved quality of life. Dr. Rosenblum lists available treatments including psychotherapy, opiates, antidepressants, antiepileptics, NMDA antagonists, topical agents, and interventional treatments such as epidurals, pulsed radiofrequency, nerve blocks, and spinal cord stimulation. Antiviral Medications Dr. Rosenblum emphasizes that antiviral drugs should be started within 72 hours of clinical onset, mentioning famciclovir, valacyclovir, and acyclovir. He notes there is no evidence for effectiveness after 72 hours in patients with uncomplicated herpes zoster. Dr. Rosenblum provides dosing information: for immunocompetent patients, famciclovir 500mg and valacyclovir 1000mg three times daily for seven days; for immunocompromised patients, famciclovir 1000mg three times daily for 10 days, while acyclovir should be given IV in the immunocompromised. Benefits of Antiviral Therapy Dr. Rosenblum explains that antiviral medication accelerates the disappearance of vesicles and crusts, promotes healing of skin lesions, and prevents new lesions from forming. By inhibiting viral replication, he notes that antiviral therapy likely reduces nerve damage, resulting in reduced incidence of postherpetic neuralgia, and should be started as soon as possible. Corticosteroids and Opioids Dr. Rosenblum discusses the use of corticosteroids, noting that when added to antiviral medications, they may reduce the severity of acute herpes zoster-related pain, though increased healing of skin lesions was not observed in one study. He mentions that a Cochrane review found oral corticosteroids ineffective in preventing postherpetic neuralgia. Regarding opioids, Dr. Rosenblum states they are commonly used alongside antivirals for controlling acute herpes zoster pain, with tramadol having a number needed to treat (NNT) of 4.7 and strong opioids having an NNT of 4.3 for 50% pain reduction. Methadone and Antidepressants Dr. Rosenblum discusses methadone as an NMDA receptor antagonist used in acute and chronic pain management, though he notes there are no randomized controlled trials determining its efficacy in acute herpes zoster pain or postherpetic neuralgia. He explains that methadone can modulate pain stimuli by inhibiting the uptake of norepinephrine and serotonin, resulting in decreased development of hyperalgesia and opioid tolerance, but has side effects including constipation, nausea, sedation, and QT prolongation that can trigger torsades de pointes. Dr. Rosenblum identifies antidepressants as first-line therapy for postherpetic neuralgia, including tricyclics and SNRIs, with tricyclics having an NNT of 3 and SNRIs an NNT of 6.4 for 50% pain reduction. Antiepileptics and Pharmacological Treatment Summary Dr. Rosenblum discusses antiepileptics like gabapentin and pregabalin for postherpetic neuralgia. He cites two trials measuring gabapentin's effect, concluding it was effective compared to placebo with a pooled NNT of 4.4, while pregabalin had an NNT of 4.9. Dr. Rosenblum summarizes that pharmacological treatment is well established for subacute herpes zoster pain, though new high-quality evidence has been lacking since the last update in 2011. Topical Agents Dr. Rosenblum discusses local anesthetic topical agents including lidocaine and capsaicin creams and patches. He notes that 8% capsaicin provided significant pain reduction during 2-8 weeks, while 5% lidocaine patches provided moderate pain relief after eight weeks of treatment. Dr. Rosenblum also mentions acute herpes zoster intracutaneous injections, citing a study where single intracutaneous injection with methylprednisolone combined with ropivacaine versus saline alone showed significant difference in VAS score at 1 and 4 weeks post-intervention favoring the intervention group. Intracutaneous Injections Dr. Rosenblum discusses the effect of repetitive intracutaneous injections with ropivacaine and methylprednisolone every 48 hours for one week. He cites a randomized control trial comparing antivirals plus analgesics to antivirals plus analgesics and repeat injections, finding the intervention group had significantly shorter duration of pain, lower VAS scores, and lower incidence of postherpetic neuralgia (6.4% vs 28% at 3 months). Dr. Rosenblum notes that a potential side effect of cutaneous methylprednisolone injection is fat atrophy, though this wasn't reported in the study. Summary of Local Anesthetics Dr. Rosenblum summarizes that there are no new studies reporting the efficacy of capsaicin 8% for postherpetic neuralgia, but it remains widely used in clinical practice and is approved in several countries. He notes that lidocaine patches can reduce pain intensity in patients with postherpetic neuralgia but may be more beneficial in patients with allodynia. Dr. Rosenblum adds that intracutaneous injections may be helpful for short periods, while repetitive injections with local anesthetics may reduce VAS scores for up to six months but can cause subcutaneous fat atrophy. Interventional Treatments: Epidural and Paravertebral Injections Dr. Rosenblum discusses interventional treatments, noting that previous guidelines found epidural injection with corticosteroids and local anesthetic as add-on therapy superior to standard care alone for up to one month in managing acute herpes zoster pain. He mentions a randomized controlled trial showing no difference between interlaminar and transforaminal epidural steroid injections for up to three months after the procedure. Dr. Rosenblum adds that previous guidelines reported high-quality evidence that paravertebral injections of corticosteroids or local anesthetic reduces pain in the active phase of herpes zoster. Comparative Studies on Injection Approaches Dr. Rosenblum discusses a trial comparing efficacy of repetitive paravertebral blocks with ropivacaine versus dexmedetomidine to prevent postherpetic neuralgia, which showed significantly lower incidence of zoster-related pain one month after therapy in the dexmedetomidine group, with effects still significant at three months. He also mentions a study comparing steroid injections administered via interlaminar versus transforaminal approaches, finding both groups had significantly lower VAS scores at 1 and 3 months follow-up compared to baseline, though this could align with the natural course of herpes zoster. Timing of Interventions and Continuous Epidural Blockade Dr. Rosenblum cites a retrospective study showing that transforaminal epidural injections administered for acute herpes zoster-related pain were associated with significantly shorter time to pain relief compared to those performed in the subacute phase. He also mentions a randomized controlled trial finding that continuous epidural blockade combined with opioids and gabapentin reduced NRS pain scores more than analgesic drug treatments alone during three-day follow-up, though both studies were low-quality. Interventions for Postherpetic Neuralgia Dr. Rosenblum discusses interventions specifically for postherpetic neuralgia, citing a small randomized controlled trial that demonstrated decreased NRS pain scores six months post-treatment for repeat versus single epidural steroid injections (15mg vs 5mg dexamethasone) administered over 24 days. The trial also found increased likelihood of complete remission during 6-month follow-up in the group receiving repeat epidural dexamethasone, though this was low-quality evidence. Summary of Epidural and Paravertebral Injections Dr. Rosenblum summarizes that epidural or paravertebral injections of local anesthetic and/or glucocorticoids could be considered in treating acute herpes zoster-related pain. For subacute postherpetic neuralgia pain, he notes low-quality evidence supporting epidural injections, while for postherpetic neuralgia, evidence supports continuous epidural infusion, though also of low quality. Dr. Rosenblum emphasizes that none of the included studies for postherpetic neuralgia investigating epidural or paravertebral injections resulted in decreased pain compared to standard therapy. Pulsed Radiofrequency (PRF) Evidence Dr. Rosenblum discusses pulsed radiofrequency (PRF), noting that previous guidelines indicated moderate quality evidence that PRF of the intercostal nerve reduces pain for 6 months in patients with postherpetic neuralgia, and very low-quality evidence that PRF to the dorsal root ganglion (DRG) reduces pain for 6 months. He mentions that multiple studies have been published since then assessing PRF efficacy. PRF Studies for Acute Herpes Zoster Dr. Rosenblum discusses a randomized controlled trial with 60 patients comparing high-voltage bipolar PRF of the cervical sympathetic chain versus sham, with treatment repeated after three days in both groups. He reports that VAS scores in the PRF group at each post-interventional point (1 day, 2 days, 1 month, 2 months, 3 months) were significantly lower than in the sham group, and at 3 months, the incidence of postherpetic neuralgia was 16.7% in the PRF group compared to 40% in the sham group. PRF for Trigeminal Neuralgia Dr. Rosenblum cites another randomized controlled trial evaluating high-voltage long-duration PRF of the Gasserian ganglion in 96 patients with subacute herpes-related trigeminal neuralgia, which found decreased VAS pain scores at all post-interventional time points (3, 7, 14 days and 1, 3, and 6 months) compared to the sham group. He also mentions a randomized comparative effectiveness study in 120 patients with subacute trigeminal herpes zoster, comparing a single application of high-voltage PRF to the Gasserian ganglion versus three cycles of conventional PRF treatment, finding significantly lower mean VAS pain scores for up to six months in the high-voltage PRF group. PRF Compared to Other Interventions Dr. Rosenblum discusses a randomized controlled trial comparing PRF to short-term spinal cord stimulation, which found decreased pain and improved 36-item short-form health survey scores in both groups at six months. He also mentions a randomized controlled trial in 72 patients where PRF of spinal nerves or peripheral branches of cranial nerves combined with five-day infusion of IV lidocaine resulted in greater pain reduction, less rescue analgesia, and reduced inflammatory cytokines at two months compared to PRF with saline infusions. Dr. Rosenblum notes a major limitation of this study was not accounting for the high natural recovery rate. Summary of PRF and Final Recommendations Dr. Rosenblum summarizes that PRF provides significant pain relief lasting over three months in patients with subacute herpes zoster and postherpetic neuralgia. He notes that since few studies have compared PRF versus sham, it's not possible to calculate an accurate number needed to treat. Dr. Rosenblum mentions there are no comparative studies comparing PRF to the intercostal nerves versus PRF of the DRG, but both preclinical and clinical studies suggest superiority of the DRG approach. He adds that evidence for spinal cord stimulation for postherpetic neuralgia is of low quality, and more research is needed given its invasive nature. Sympathetic Blocks and Conclusion Dr. Rosenblum notes there is low-quality evidence for using sympathetic blocks to treat acute herpes zoster-related pain, but no evidence for their use in postherpetic neuralgia. He mentions that risks of treatment with intrathecal methylprednisolone are unclear and therefore not recommended. Dr. Rosenblum concludes by praising the comprehensive article he's been discussing and mentions it provides insight for treating his patients, including a recent case of trigeminal postherpetic neuralgia. Personal Clinical Approach and Closing Dr. Rosenblum shares that he doesn't currently perform PRF in his practice, partly because it's not standard of care and not well reimbursed, creating barriers to implementation. However, he notes that PRF is a very safe procedure as it doesn't involve burning tissue. For his patient with trigeminal neuralgia pain, Dr. Rosenblum plans to try a topical sphenopalatine ganglion block as the least invasive intervention before considering injecting the trigeminal nerves at the foramen, in addition to pharmacotherapy. He concludes by thanking listeners, encouraging them to check the show notes and links, mentioning institutional memberships and shadowing opportunities, and asking listeners to rate and share the podcast. Q&A No Q&A session in this lecture Pain Management Board Prep   Ultrasound Training REGISTER TODAY!   Create an Account and get Free Access to the PainExam- NRAP Academy Community Highlights     David Rosenblum, MD, currently serves as the Director of Pain Management at Maimonides Medical Center and AABP Integrative Pain Care.  As a member of the Department of Anesthesiology, he is involved in teaching, research, CME activities, and was key faculty in developing the anesthesiology residency's regional anesthesia block rotation, as well as institutional wide acute and chronic pain management protocols to ensure safe and effective pain management. He currently is a managing partner in a multi-physician private pain practice, AABP Integrative Pain Care, located in Brooklyn, NY. He is one of the earliest interventional pain physicians to integrate ultrasound guidance to improve the safety and accuracy of interventional pain procedures.   Awards New York Magazine: Top Doctors: 2016, 2017, 2018, 2021, 2022, 2023, 2024, 2025 Schneps Media: 2015, 2016, 2017, 2019, 2020 Top Doctors New York Metro Area (digital guide): 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023 2025 Schneps Media - Brooklyn Courier Life: 2021, 2022, 2023   Dr. Rosenblum written several book chapters on Peripheral Neuromodulation, Radiofrequency Ablation, and Pharmacology.  He has published numerous noteworthy articles and most recently is developing the ASIPP Guidelines for Peripheral Neuromodulation in the treatment of chronic pain. He has been named several times in NY Magazine's Best Pain Management Doctor List, Nassau County's Best Pain Physician, has appeared on NY1 News, and has made several appearances on XM Radio's Doctor Talk. He currently is lecturing on a national and international level and has partnered with the American Society of Interventional Pain Physicians (ASIPP), American Society of Pain and Neuroscience (ASPN), IASP Mexican Chapter, Eastern Pain Association (EPA), the North American Neuromodulation Society (NANS), World Academy of Pain Medicine United, as well as various other organizations, to support educational events and develop new courses. Since 2008, he has helped over 3000 physicians pass the Pain Management Boards, and has been at the forefront of utilizing ultrasound guidance to perform pain procedures.  He now hosts the PainExam podcast, AnesthesiaExam Podcast, PMRExam Podcasts and uses this platform to promote the safe and effective use of ultrasound in the performance of various procedures such as Peripheral Nerve Stimulation, Caudal Epidurals, Selective Nerve Root Blocks, Cluneal Nerve Blocks, Ganglion impar Blocks, Stellate Ganglion Blocks, Brachial Plexus Blocks, Joint Injections and much more!   Doctor Rosenblum created the NRAP (Neuromodulation Regional Anesthesia and Pain) Academy  and travels to teach various courses focused on Pain Medicine, Regenerative Medicine, Ultrasound Guided Pain Procedures and Regional Anesthesia Techniques.  Dr. Rosenblum is persistent when it comes to eliminating pain and has gained a reputation among his patients for thinking "outside the box" and implements ultrasound guidance to deposit medications, biologics (PRP, Bone Marrow Aspirate, etc.) and Peripheral Nerve Stimulators near pain generators. He is currently treating patients in his great neck and Brooklyn office.  For an appointment go to AABPpain.com or call Brooklyn     718 436 7246 Reference Adriaansen, E. J., Jacobs, J. G., Vernooij, L. M., van Wijck, A. J., Cohen, S. P., Huygen, F. J., & Rijsdijk, M. (2025). 8. Herpes zoster and post herpetic neuralgia. Pain Practice, 25(1), e13423.

Summary In this episode of the Pain Exam Podcast, Dr. David Rosenblum provides a comprehensive review of herpes zoster and postherpetic neuralgia (PHN), focusing on pathophysiology, diagnosis, and treatment options. Dr. Rosenblum explains that postherpetic neuralgia affects approximately 25% of patients with acute herpes zoster, causing debilitating unilateral chronic pain in one or more dermatomes. He discusses the three phases of herpes zoster: acute (up to 30 days), subacute (up to 3 months), and postherpetic neuralgia (pain continuing beyond 3 months). Dr. Rosenblum identifies risk factors for developing PHN, including older age, female sex, immunosuppression, prodromal pain, severe rash, and greater acute pain severity. He details the pathophysiology involving peripheral and central sensitization, and explains different phenotypes of PHN that can guide treatment approaches. For treatment, Dr. Rosenblum reviews various options including antiviral medications (which should be started within 72 hours of onset), corticosteroids, opioids, antidepressants (particularly tricyclics and SNRIs), antiepileptics (gabapentin and pregabalin), topical agents (lidocaine and capsaicin), and interventional procedures such as epidural injections and pulsed radiofrequency. He emphasizes that prevention through vaccination with Shingrix is highly effective, with 97% effectiveness in preventing herpes zoster in patients 50-69 years old and 89% effectiveness in those over 70. Dr. Rosenblum mentions that he's currently treating a patient with trigeminal postherpetic neuralgia and is considering a topical sphenopalatine ganglion block as a minimally invasive intervention before attempting more invasive procedures. Chapters Introduction to the Pain Exam Podcast and Topic Overview Dr. David Rosenblum introduces the Pain Exam Podcast, mentioning that it covers painful disorders, alternative treatments, and practice management. He explains that this episode focuses on herpes zoster and postherpetic neuralgia as board preparation for fellows starting their programs, with ABA boards coming up in September. Dr. Rosenblum notes that he's not only preparing listeners for boards but also seeking the latest information to help treat his own patients with this notoriously difficult disease. Upcoming Conferences and Educational Opportunities Dr. Rosenblum announces several upcoming conferences including Aspen in July, Pain Week in September, and events with NYSIP and the Latin American Pain Society. He mentions he'll be teaching ultrasound and regenerative medicine at these events. Dr. Rosenblum invites listeners to sign up at nrappain.org to access a community discussing regenerative medicine, ultrasound-guided pain medicine, regional anesthesia, and board preparation. He also offers ultrasound training in New York and elsewhere, with upcoming sessions in Manhattan on July 12th and October 4th, plus private shadowing opportunities. Overview of Postherpetic Neuralgia Dr. Rosenblum defines postherpetic neuralgia as typically a unilateral chronic pain in one or more dermatomes after acute herpes zoster infection. He states that the incidence of acute herpes zoster ranges between 3-5 patients per thousand person-years, and one in four patients with acute herpes zoster-related pain will transition into postherpetic neuralgia. Dr. Rosenblum emphasizes that while this condition won't kill patients, it can be extremely debilitating and significantly reduce quality of life. Treatment Options Overview Dr. Rosenblum reviews treatment options according to the WHO pain ladder, including tricyclics like nortriptyline and antiepileptic drugs such as gabapentin. He explains that if pain is not significantly reduced, interventional treatments like epidural injections with local anesthetics and corticosteroids or pulsed radiofrequency of the dorsal root ganglion are options. For postherpetic neuralgia specifically, Dr. Rosenblum notes that preferred treatments include transdermal capsaicin, lidocaine, or oral drugs such as antidepressants or antiepileptics. Phases of Herpes Zoster and Definitions Dr. Rosenblum outlines the three phases during herpes zoster reactivation: acute herpes zoster-related pain (lasting maximum 30 days), subacute herpes zoster-related pain (pain after healing of vesicles but disappearing within 3 months), and postherpetic neuralgia (typically defined as pain continuing after 3 months). He mentions that acute herpes zoster pain often begins with prodromal pain starting a few days before the appearance of the rash. Incidence and Risk Factors Dr. Rosenblum states that the incidence of herpes zoster ranges between 3-5 patients per 1,000 person-years, with approximately 5-30% of cases leading to postherpetic neuralgia. He identifies risk factors including older age, female sex, immunosuppression, prodromal pain, severe rash, and greater acute pain severity. Dr. Rosenblum describes the clinical manifestations as a mosaic of somatosensory symptoms including burning, deep aching pain, tingling, itching, stabbing, often associated with tactile and cold allodynia. Impact on Quality of Life Dr. Rosenblum emphasizes that postherpetic neuralgia can be debilitating, impacting both physical and emotional functioning and causing decreased quality of life. He notes that it leads to fatigue, insomnia, depression, anorexia, anxiety, and emotional distress. Dr. Rosenblum stresses the importance of exploring methods for prevention of postherpetic neuralgia and optimizing pain treatment for both subacute herpes zoster-related pain and postherpetic neuralgia. Literature Review and Pathophysiology Dr. Rosenblum mentions that he's discussing a literature review from 2024 that updates previous practical guidelines published in 2011. He explains the pathophysiology of postherpetic neuralgia, which involves sensitization of peripheral and sensory nerves from damage. Dr. Rosenblum describes how inflammatory mediators reduce the stimulus threshold of nociceptors and increase responsiveness, resulting in pathological spontaneous discharges, lower thresholds for thermal and mechanical stimuli, and hyperalgesia. Central Sensitization and Nerve Damage Dr. Rosenblum explains that central sensitization results from peripheral nociceptor hyperactivity leading to plastic changes in the central nervous system, involving amplification of pain signals and reduced inhibition. He describes how nerve damage in postherpetic neuralgia patients results from neuronal death due to severe inflammatory stimuli or secondary to neuronal swelling. Dr. Rosenblum notes that motor defects occur in 0.05% of patients with herpes zoster, observed as abdominal pseudohernias or motor weakness of limbs limited to the affected myotome. Different Phenotypes and Classification Dr. Rosenblum discusses different phenotypes of postherpetic neuralgia and how phenotyping can determine treatment. He explains that there are several ways to classify the phenotypes, with one categorizing patients into three subtypes: sensory loss (most common), thermal gain, and thermal loss with mechanical gain. Dr. Rosenblum describes the mechanistic categorization, including the irritable nociceptive phenotype characterized by preserved sensation, profound dynamic mechanical allodynia, reduced pressure pain threshold, and relief with local anesthetic infiltration. Deafferentation Phenotype Dr. Rosenblum explains that a deafferentation phenotype may arise from destruction of neurons by the virus in the dorsal root ganglion. This phenotype is characterized by sensory loss, including thermal and vibratory sensation without prominent thermal allodynia. He notes that mechanical allodynia can occur secondary to A-beta fibers activating spinothalamic pathways (known as phenotypic switches), along with pressure hyperalgesia and temporal summation suggesting central sensitization. Dr. Rosenblum mentions that in one study, this phenotype was present in 10.8% of individuals, and for those with deafferentation pain, gabapentinoids, antidepressants, and neuromodulatory therapies like repetitive transcranial magnetic stimulation may be beneficial. Diagnosis and Physical Examination Dr. Rosenblum discusses the diagnosis of herpes zoster and postherpetic neuralgia, emphasizing the importance of physical examination. He explains that diagnosis is based on the rash, redness, papules, and vesicles in the painful dermatomes, with healing vesicles showing crust formation. Dr. Rosenblum notes that the rash is generally unilateral and does not cross the midline of the body. In postherpetic neuralgia patients, he mentions that scarring, hyper or hypopigmentation is often visible, with allodynia present in 45-75% of affected patients. Sensory Testing and Assessment Dr. Rosenblum explains that in patients with postherpetic neuralgia, a mosaic of somatosensory alterations can occur, manifesting as hyperalgesia, allodynia, and sensory loss. These can be quantified by quantitative sensory testing, which assesses somatosensory functions, dermal detection thresholds for perception of cold, warmth, and paradoxical heat sensations. He notes that testing can provide clues regarding underlying mechanisms of pain, impaired conditioned pain modulation, temporal summation suggesting central sensitization, and information about the type of nerve damage and surviving afferent neurons. Prevention Through Vaccination Dr. Rosenblum discusses prevention of acute herpes zoster through vaccination, noting that the risk increases with reduced immunity. He highlights studies evaluating Shingrix, a vaccine for herpes zoster, which showed 97% effectiveness in preventing herpes zoster in patients 50-69 years old with healthy immune systems and 89% effectiveness in patients over 70. Dr. Rosenblum states that Shingrix is 89-91% effective in preventing postherpetic neuralgia development in patients with healthy immune systems and 68-91% effective in those with weakened or underlying conditions. Treatment Objectives Dr. Rosenblum outlines the treatment objectives for herpes zoster and postherpetic neuralgia. For acute herpes zoster, objectives include relieving pain, reducing severity and duration of pain, accelerating recovery of epidermal defects, and preventing secondary infections. For postherpetic neuralgia, the objectives are pain alleviation and improved quality of life. Dr. Rosenblum lists available treatments including psychotherapy, opiates, antidepressants, antiepileptics, NMDA antagonists, topical agents, and interventional treatments such as epidurals, pulsed radiofrequency, nerve blocks, and spinal cord stimulation. Antiviral Medications Dr. Rosenblum emphasizes that antiviral drugs should be started within 72 hours of clinical onset, mentioning famciclovir, valacyclovir, and acyclovir. He notes there is no evidence for effectiveness after 72 hours in patients with uncomplicated herpes zoster. Dr. Rosenblum provides dosing information: for immunocompetent patients, famciclovir 500mg and valacyclovir 1000mg three times daily for seven days; for immunocompromised patients, famciclovir 1000mg three times daily for 10 days, while acyclovir should be given IV in the immunocompromised. Benefits of Antiviral Therapy Dr. Rosenblum explains that antiviral medication accelerates the disappearance of vesicles and crusts, promotes healing of skin lesions, and prevents new lesions from forming. By inhibiting viral replication, he notes that antiviral therapy likely reduces nerve damage, resulting in reduced incidence of postherpetic neuralgia, and should be started as soon as possible. Corticosteroids and Opioids Dr. Rosenblum discusses the use of corticosteroids, noting that when added to antiviral medications, they may reduce the severity of acute herpes zoster-related pain, though increased healing of skin lesions was not observed in one study. He mentions that a Cochrane review found oral corticosteroids ineffective in preventing postherpetic neuralgia. Regarding opioids, Dr. Rosenblum states they are commonly used alongside antivirals for controlling acute herpes zoster pain, with tramadol having a number needed to treat (NNT) of 4.7 and strong opioids having an NNT of 4.3 for 50% pain reduction. Methadone and Antidepressants Dr. Rosenblum discusses methadone as an NMDA receptor antagonist used in acute and chronic pain management, though he notes there are no randomized controlled trials determining its efficacy in acute herpes zoster pain or postherpetic neuralgia. He explains that methadone can modulate pain stimuli by inhibiting the uptake of norepinephrine and serotonin, resulting in decreased development of hyperalgesia and opioid tolerance, but has side effects including constipation, nausea, sedation, and QT prolongation that can trigger torsades de pointes. Dr. Rosenblum identifies antidepressants as first-line therapy for postherpetic neuralgia, including tricyclics and SNRIs, with tricyclics having an NNT of 3 and SNRIs an NNT of 6.4 for 50% pain reduction. Antiepileptics and Pharmacological Treatment Summary Dr. Rosenblum discusses antiepileptics like gabapentin and pregabalin for postherpetic neuralgia. He cites two trials measuring gabapentin's effect, concluding it was effective compared to placebo with a pooled NNT of 4.4, while pregabalin had an NNT of 4.9. Dr. Rosenblum summarizes that pharmacological treatment is well established for subacute herpes zoster pain, though new high-quality evidence has been lacking since the last update in 2011. Topical Agents Dr. Rosenblum discusses local anesthetic topical agents including lidocaine and capsaicin creams and patches. He notes that 8% capsaicin provided significant pain reduction during 2-8 weeks, while 5% lidocaine patches provided moderate pain relief after eight weeks of treatment. Dr. Rosenblum also mentions acute herpes zoster intracutaneous injections, citing a study where single intracutaneous injection with methylprednisolone combined with ropivacaine versus saline alone showed significant difference in VAS score at 1 and 4 weeks post-intervention favoring the intervention group. Intracutaneous Injections Dr. Rosenblum discusses the effect of repetitive intracutaneous injections with ropivacaine and methylprednisolone every 48 hours for one week. He cites a randomized control trial comparing antivirals plus analgesics to antivirals plus analgesics and repeat injections, finding the intervention group had significantly shorter duration of pain, lower VAS scores, and lower incidence of postherpetic neuralgia (6.4% vs 28% at 3 months). Dr. Rosenblum notes that a potential side effect of cutaneous methylprednisolone injection is fat atrophy, though this wasn't reported in the study. Summary of Local Anesthetics Dr. Rosenblum summarizes that there are no new studies reporting the efficacy of capsaicin 8% for postherpetic neuralgia, but it remains widely used in clinical practice and is approved in several countries. He notes that lidocaine patches can reduce pain intensity in patients with postherpetic neuralgia but may be more beneficial in patients with allodynia. Dr. Rosenblum adds that intracutaneous injections may be helpful for short periods, while repetitive injections with local anesthetics may reduce VAS scores for up to six months but can cause subcutaneous fat atrophy. Interventional Treatments: Epidural and Paravertebral Injections Dr. Rosenblum discusses interventional treatments, noting that previous guidelines found epidural injection with corticosteroids and local anesthetic as add-on therapy superior to standard care alone for up to one month in managing acute herpes zoster pain. He mentions a randomized controlled trial showing no difference between interlaminar and transforaminal epidural steroid injections for up to three months after the procedure. Dr. Rosenblum adds that previous guidelines reported high-quality evidence that paravertebral injections of corticosteroids or local anesthetic reduces pain in the active phase of herpes zoster. Comparative Studies on Injection Approaches Dr. Rosenblum discusses a trial comparing efficacy of repetitive paravertebral blocks with ropivacaine versus dexmedetomidine to prevent postherpetic neuralgia, which showed significantly lower incidence of zoster-related pain one month after therapy in the dexmedetomidine group, with effects still significant at three months. He also mentions a study comparing steroid injections administered via interlaminar versus transforaminal approaches, finding both groups had significantly lower VAS scores at 1 and 3 months follow-up compared to baseline, though this could align with the natural course of herpes zoster. Timing of Interventions and Continuous Epidural Blockade Dr. Rosenblum cites a retrospective study showing that transforaminal epidural injections administered for acute herpes zoster-related pain were associated with significantly shorter time to pain relief compared to those performed in the subacute phase. He also mentions a randomized controlled trial finding that continuous epidural blockade combined with opioids and gabapentin reduced NRS pain scores more than analgesic drug treatments alone during three-day follow-up, though both studies were low-quality. Interventions for Postherpetic Neuralgia Dr. Rosenblum discusses interventions specifically for postherpetic neuralgia, citing a small randomized controlled trial that demonstrated decreased NRS pain scores six months post-treatment for repeat versus single epidural steroid injections (15mg vs 5mg dexamethasone) administered over 24 days. The trial also found increased likelihood of complete remission during 6-month follow-up in the group receiving repeat epidural dexamethasone, though this was low-quality evidence. Summary of Epidural and Paravertebral Injections Dr. Rosenblum summarizes that epidural or paravertebral injections of local anesthetic and/or glucocorticoids could be considered in treating acute herpes zoster-related pain. For subacute postherpetic neuralgia pain, he notes low-quality evidence supporting epidural injections, while for postherpetic neuralgia, evidence supports continuous epidural infusion, though also of low quality. Dr. Rosenblum emphasizes that none of the included studies for postherpetic neuralgia investigating epidural or paravertebral injections resulted in decreased pain compared to standard therapy. Pulsed Radiofrequency (PRF) Evidence Dr. Rosenblum discusses pulsed radiofrequency (PRF), noting that previous guidelines indicated moderate quality evidence that PRF of the intercostal nerve reduces pain for 6 months in patients with postherpetic neuralgia, and very low-quality evidence that PRF to the dorsal root ganglion (DRG) reduces pain for 6 months. He mentions that multiple studies have been published since then assessing PRF efficacy. PRF Studies for Acute Herpes Zoster Dr. Rosenblum discusses a randomized controlled trial with 60 patients comparing high-voltage bipolar PRF of the cervical sympathetic chain versus sham, with treatment repeated after three days in both groups. He reports that VAS scores in the PRF group at each post-interventional point (1 day, 2 days, 1 month, 2 months, 3 months) were significantly lower than in the sham group, and at 3 months, the incidence of postherpetic neuralgia was 16.7% in the PRF group compared to 40% in the sham group. PRF for Trigeminal Neuralgia Dr. Rosenblum cites another randomized controlled trial evaluating high-voltage long-duration PRF of the Gasserian ganglion in 96 patients with subacute herpes-related trigeminal neuralgia, which found decreased VAS pain scores at all post-interventional time points (3, 7, 14 days and 1, 3, and 6 months) compared to the sham group. He also mentions a randomized comparative effectiveness study in 120 patients with subacute trigeminal herpes zoster, comparing a single application of high-voltage PRF to the Gasserian ganglion versus three cycles of conventional PRF treatment, finding significantly lower mean VAS pain scores for up to six months in the high-voltage PRF group. PRF Compared to Other Interventions Dr. Rosenblum discusses a randomized controlled trial comparing PRF to short-term spinal cord stimulation, which found decreased pain and improved 36-item short-form health survey scores in both groups at six months. He also mentions a randomized controlled trial in 72 patients where PRF of spinal nerves or peripheral branches of cranial nerves combined with five-day infusion of IV lidocaine resulted in greater pain reduction, less rescue analgesia, and reduced inflammatory cytokines at two months compared to PRF with saline infusions. Dr. Rosenblum notes a major limitation of this study was not accounting for the high natural recovery rate. Summary of PRF and Final Recommendations Dr. Rosenblum summarizes that PRF provides significant pain relief lasting over three months in patients with subacute herpes zoster and postherpetic neuralgia. He notes that since few studies have compared PRF versus sham, it's not possible to calculate an accurate number needed to treat. Dr. Rosenblum mentions there are no comparative studies comparing PRF to the intercostal nerves versus PRF of the DRG, but both preclinical and clinical studies suggest superiority of the DRG approach. He adds that evidence for spinal cord stimulation for postherpetic neuralgia is of low quality, and more research is needed given its invasive nature. Sympathetic Blocks and Conclusion Dr. Rosenblum notes there is low-quality evidence for using sympathetic blocks to treat acute herpes zoster-related pain, but no evidence for their use in postherpetic neuralgia. He mentions that risks of treatment with intrathecal methylprednisolone are unclear and therefore not recommended. Dr. Rosenblum concludes by praising the comprehensive article he's been discussing and mentions it provides insight for treating his patients, including a recent case of trigeminal postherpetic neuralgia. Personal Clinical Approach and Closing Dr. Rosenblum shares that he doesn't currently perform PRF in his practice, partly because it's not standard of care and not well reimbursed, creating barriers to implementation. However, he notes that PRF is a very safe procedure as it doesn't involve burning tissue. For his patient with trigeminal neuralgia pain, Dr. Rosenblum plans to try a topical sphenopalatine ganglion block as the least invasive intervention before considering injecting the trigeminal nerves at the foramen, in addition to pharmacotherapy. He concludes by thanking listeners, encouraging them to check the show notes and links, mentioning institutional memberships and shadowing opportunities, and asking listeners to rate and share the podcast. Q&A No Q&A session in this lecture Pain Management Board Prep   Ultrasound Training REGISTER TODAY!   Create an Account and get Free Access to the PainExam- NRAP Academy Community Highlights     David Rosenblum, MD, currently serves as the Director of Pain Management at Maimonides Medical Center and AABP Integrative Pain Care.  As a member of the Department of Anesthesiology, he is involved in teaching, research, CME activities, and was key faculty in developing the anesthesiology residency's regional anesthesia block rotation, as well as institutional wide acute and chronic pain management protocols to ensure safe and effective pain management. He currently is a managing partner in a multi-physician private pain practice, AABP Integrative Pain Care, located in Brooklyn, NY. He is one of the earliest interventional pain physicians to integrate ultrasound guidance to improve the safety and accuracy of interventional pain procedures.   Awards New York Magazine: Top Doctors: 2016, 2017, 2018, 2021, 2022, 2023, 2024, 2025 Schneps Media: 2015, 2016, 2017, 2019, 2020 Top Doctors New York Metro Area (digital guide): 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023 2025 Schneps Media - Brooklyn Courier Life: 2021, 2022, 2023   Dr. Rosenblum written several book chapters on Peripheral Neuromodulation, Radiofrequency Ablation, and Pharmacology.  He has published numerous noteworthy articles and most recently is developing the ASIPP Guidelines for Peripheral Neuromodulation in the treatment of chronic pain. He has been named several times in NY Magazine's Best Pain Management Doctor List, Nassau County's Best Pain Physician, has appeared on NY1 News, and has made several appearances on XM Radio's Doctor Talk. He currently is lecturing on a national and international level and has partnered with the American Society of Interventional Pain Physicians (ASIPP), American Society of Pain and Neuroscience (ASPN), IASP Mexican Chapter, Eastern Pain Association (EPA), the North American Neuromodulation Society (NANS), World Academy of Pain Medicine United, as well as various other organizations, to support educational events and develop new courses. Since 2008, he has helped over 3000 physicians pass the Pain Management Boards, and has been at the forefront of utilizing ultrasound guidance to perform pain procedures.  He now hosts the PainExam podcast, AnesthesiaExam Podcast, PMRExam Podcasts and uses this platform to promote the safe and effective use of ultrasound in the performance of various procedures such as Peripheral Nerve Stimulation, Caudal Epidurals, Selective Nerve Root Blocks, Cluneal Nerve Blocks, Ganglion impar Blocks, Stellate Ganglion Blocks, Brachial Plexus Blocks, Joint Injections and much more!   Doctor Rosenblum created the NRAP (Neuromodulation Regional Anesthesia and Pain) Academy  and travels to teach various courses focused on Pain Medicine, Regenerative Medicine, Ultrasound Guided Pain Procedures and Regional Anesthesia Techniques.  Dr. Rosenblum is persistent when it comes to eliminating pain and has gained a reputation among his patients for thinking "outside the box" and implements ultrasound guidance to deposit medications, biologics (PRP, Bone Marrow Aspirate, etc.) and Peripheral Nerve Stimulators near pain generators. He is currently treating patients in his great neck and Brooklyn office.  For an appointment go to AABPpain.com or call Brooklyn     718 436 7246 Reference Adriaansen, E. J., Jacobs, J. G., Vernooij, L. M., van Wijck, A. J., Cohen, S. P., Huygen, F. J., & Rijsdijk, M. (2025). 8. Herpes zoster and post herpetic neuralgia. Pain Practice, 25(1), e13423.

Nine years ago, Mark Durante received a heart transplant that saved his life—but it was just the beginning of his healing journey. When post-transplant neuropathy nearly disabled him, he turned to a friend in stem cell research. What happened next changed everything.This episode dives deep into how exosomes work, what makes 3D manufacturing a breakthrough, and why regenerative medicine isn't just for the rich and famous anymore. We compare exosomes to stem cells, explore cost and accessibility, and look at the growing global research. Whether you're a practitioner or just health-curious, this conversation might change the way you think about aging, healing, and what's possible for the human body.HIGHLIGHTS[01:10] – Mark's heart transplant story and how post-op pain led to a regenerative medicine journey[02:45] – Discovering exosomes through stem cell therapy and getting off neurological meds[05:22] – The birth of Rise Up Medical and turning healing into purpose[09:00] – Exosomes 101: what they are and why they matter[11:30] – Stem cells vs exosomes: when and why they're used[16:00] – The 3D manufacturing breakthrough and why it changes everything[22:30] – Use cases: from arthritis to anti-aging to advanced neurological support[29:00] – What regenerative treatments cost—and why smart dosing matters[34:40] – How to find a practitioner or get your doctor on board[43:00] – Global studies, real results, and what's coming next in regenerative careGUEST RESOURCESRize Up Medical: https://www.rizeupmedical.comContact Mark's Team: 469-269-0844Instagram: https://www.instagram.com/rizeupmedicalUpgrade Your WellnessBEAM Minerals: http://beamminerals.com/beautifullybrokenUse code beautifullybroken for 20% offFlowpresso: https://calendly.com/freddiekimmel/flowpresso-one-on-one-discoverySilver Biotics Wound Healing Gel: https://bit.ly/3JnxyDD30% off Use Code: BEAUTIFULLYBROKEN for DiscountStemRegen: https://www.stemregen.co/products/stemregen?_ef_transaction_id=&oid=1&affid=52Code: beautifullybrokenLightPathLED: https://lightpathled.pxf.io/c/3438432/2059835/25794code: beautifullybroken CONNECT WITH FREDDIECheck out my website and store: (http://www.beautifullybroken.world) Instagram: (https://www.instagram.com/beautifullybroken.world/) YouTube: (https://www.youtube.com/@BeautifullyBrokenWorld)

  What if everything you learned about health and medical school is missing the real secrets to thriving, energetic living? In this premiere episode of the 2025 season of Health Hacks, Mark L. White pulls back the curtain on cutting-edge approaches that most doctors still aren't teaching—straight from one of Miami's leaders in regenerative and functional medicine, Dr. Kendrick Heywood. Episode Summary: Join host Mark L. White and guest Dr. Kendrick Heywood for a deep dive into the essential “five pillars” of health—covering everything from individualized nutrition, gene-driven exercise, optimal supplementation, hormone optimization, and breakthrough biohacks. Dr. Heywood reveals how he transitioned from traditional internal medicine to the forefront of anti-aging therapies, why most med schools still neglect these advancements, and how everyday patients (not just athletes!) can radically transform their health outcomes. Key Highlights: Myth-Busting Medicine: Discover why Dr. Heywood says 0% of what he uses today to optimize patient health was taught in med school. Personalized Diet & Exercise: Learn why the best approach for you isn't a fad diet—but a regimen designed for your unique genetic makeup. Hormone Optimization Demystified: Get the real story on hormone therapies, peptides, and why targeting the “top end” of health can change everything. Next-Level Biohacks: From red light therapy and hypberbaric chambers to exosomes and shockwave treatment—find out which futuristic tools Dr. Heywood recommends and why. Behind-the-Scenes Stories: Hear the incredible story of how Dr. Heywood saved NBA legend Dennis Rodman, and what it means to go above and beyond for patient care. Putting It Into Action—Listener Takeaways: Assess Your Pillars: Start by evaluating your own five pillars—are you optimizing each, or stuck in old routines? Get Personalized: Consider genetic testing to unlock your best diet and fitness plan, rather than chasing one-size-fits-all trends. Explore Biohacks Safely: Research and, if possible, consult with experts about the safest, most effective regenerative therapies (like red light therapy or IV vitamin drips). Ask About Hormones & Peptides: If you keep hitting fitness or wellness plateaus, consult a forward-thinking practitioner about hormone and peptide therapies tailored to your needs (not just based on “normal” ranges). Connect for Expert Guidance: Follow Dr. Heywood on Instagram (@drkenhaywood) for daily educational tips and updates on the latest in health optimization. Ready to take your health (and possibly your career) to the next level with strategies most doctors don't even know exist? Tune in—your path to a more thriving, energetic you starts here. Don't forget to subscribe to Health Hacks and visit omniwave.com for exclusive offers and more ways to take control of your health journey! Timestamped Overview 00:00 Anti-Aging Revolution in Miami 04:21 FDA Removes Testosterone Warning 08:53 Gene-Based Exercise Goals 12:24 Personalized Patient Care Evolution 15:27 Exploring Effective Biohacking Techniques 19:08 Becoming My Own Influencer 20:29 Hormones Aren't A Weight Loss Cure 24:22 Pioneers of Exosome Innovation 28:06 Elevating Influence and Global Outreach 29:49 "Health Hacks Podcast Promo"  

What if your body had built-in tools to regenerate itself but you've been looking in the wrong places? Dr. Khoshal Latifzai reveals overlooked therapies like peptides, shockwave, stem cells, & ketamine that go beyond symptom masking. He explains how athletes & longevity seekers use diagnostics, fasting, & advanced biologics to stay ahead of aging & feel better, faster. Meet our guest Dr. Khoshal Latifzai is a Yale-trained, board-certified emergency physician who founded Rocky Mountain Regenerative Medicine to focus on prevention, longevity & performance. Inspired by his humanitarian work & experience in critical care, he blends advanced biologics, hormone optimization & regenerative therapies to treat pain, enhance vitality & extend healthspan. His personalized approach serves athletes, executives & anyone seeking to thrive at every stage of life. Thank you to our partners Outliyr Biohacker's Peak Performance Shop: get exclusive discounts on cutting-edge health, wellness, & performance gear Ultimate Health Optimization Deals: a database of of all the current best biohacking deals on technology, supplements, systems and more Latest Summits, Conferences, Masterclasses, and Health Optimization Events: join me at the top events around the world FREE Outliyr Nootropics Mini-Course: gain mental clarity, energy, motivation, and focus Key takeaways Track biomarkers regularly through frequent, detailed bloodwork to personalize health strategies & catch negative effects early Cycle medications & supplements like peptides & metformin to prevent tolerance & maintain effectiveness Personalize metformin use since benefits, dosing & side effects vary Use low-dose rapamycin for potential longevity benefits, monitoring closely with regular biomarker testing Go beyond standard panels by checking ApoB, Lp(a) & homocysteine for better insight into cardiovascular risk Question outlier biomarkers like A1C by considering factors such as red blood cell lifespan before making assumptions Use ketamine therapy under supervision to address depression & anxiety when conventional treatments fall short Trigger targeted repair in joints or tissues using shockwave therapy to activate local stem cell healing Bank stem cells early while they're younger & more effective to improve outcomes for future injuries or illnesses Support stem cell health with regular fasting, exercise & optimized metabolic function to maintain potency with age Episode Highlights 09:39 Metformin & Rapamycin for Longevity 16:53 Underrated Biomarkers & Diagnostics 24:23 Ketamine Therapy for Brain Remodelling 45:30 Shockwave & Stem Cell Therapy Deep Dive   Links Watch it on YouTube: https://youtu.be/UbA4DzzNqN0  Full episode show notes: outliyr.com/214 Connect with Nick on social media Instagram Twitter (X) YouTube LinkedIn Easy ways to support Subscribe Leave an Apple Podcast review Suggest a guest Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you! Be an Outliyr, Nick

In this episode of the Stronger Bones Lifestyle Podcast, I welcome back Dr. Jeff Gross—renowned regenerative medicine specialist, former neurosurgeon, and a leading voice in cutting-edge healing strategies. Together, we explore the incredible potential of stem cells, exosomes, and regenerative medicine to reverse joint degeneration, optimize bone health, and even slow the aging process.Dr. Gross explains how chronic inflammation, lifestyle stressors, and toxin exposure accelerate aging by depleting your body's stem cell function—and how biologic therapies like exosome injections can help restore vitality, repair tissues, and potentially help you avoid surgeries like joint replacements.Whether you're struggling with knee pain, bone loss, osteoporosis, or long COVID, or you're simply interested in aging with strength and mobility, this episode is a must-listen.What You'll Learn in This Episode:What stem cells are and how they function in regenerationThe difference between PRP, stem cells, and exosomesWhy exosomes may be the future of joint repair and anti-agingHow chronic inflammation leads to stem cell exhaustion and accelerated agingThe role of bone marrow as your body's regenerative powerhouseWhy targeted exosome injections into bone (not cartilage) yield better long-term resultsInsight into natural killer (NK) cell exosomes for cancer support and immune healthWhy Dr. Gross shifted from surgery to regenerative medicineThe systemic impact of lifestyle, diet, EMFs, and toxins on healingHow regenerative therapy supports osteoporosis, osteoarthritis, autoimmune conditions, and longevityResources & Links Mentioned:

Dr. Hongkui Deng is the Director of the Institute of Stem Cell Research at Peking University and Dr. Candice Liew is a Senior Scientist at Reprogenix Bioscience. In this special episode recorded in front of a live audience at ISSCR 2025 in Hong Kong, they discuss their groundbreaking study transplanting CiPSC-derived islets into a patient with type 1 diabetes. They talk about their approach to chemical reprogramming, immune tolerance, and the therapy's impact on the first patient.

In this episode, Dr. Joy Kong sits down with hormone and integrative medicine specialist Dr. Sara Amirmehrabi of Chara Health to uncover what most doctors overlook: that many modern women's struggles with mood, memory, weight gain, and intimacy may be rooted in hormone imbalances—not just lifestyle or aging.As part of the Chara Health team, Dr. Sara Amir brings her functional, root-cause approach to hormone replacement therapy, helping patients reclaim energy, joy, and clarity. She and Dr. Joy dive deep into the latest science on perimenopause, estrogen receptors in the brain, and why a tailored HRT protocol can be life-changing for women at any age.Whether you're in your 30s and feeling off or postmenopausal and afraid to try hormones again, this episode offers science-backed hope. You'll also learn how regenerative medicine like stem cells and peptides can enhance and amplify the effects of hormone therapy—creating a true foundation for anti-aging and vitality.If you've ever been told “everything looks normal” but you know something's not right, this conversation is for you.Additional Resources:Visit My Clinic: Chara Health

Dr. Luiz E. Bertassoni is the founding director of the Knight Cancer Precision Biofabrication Hub and Professor in the Division of Oncological Sciences at the Knight Cancer Institute, where he is also co-section head for Discovery and Translational Oncology. He is also faculty in the Department of Biomedical Engineering, the Cancer Early Detection Advanced Research (CEDAR) Center, and the Oregon Health and Sciences University (OHSU) School of Dentistry. Luiz is co-founder of 2 biotech spin-off companies which resulted from his work on cancer research and regenerative medicine: he is Co-Founder and Chief Technology Officer of HuMarrow and Co-Founder and Chief Medical Officer of RegendoDent. Outside of science, Luiz is a big fan of surfing, and he enjoyed frequent trips to the beach while completing his PhD in Sydney, Australia, and a postdoctoral fellowship in San Francisco, California. In addition to spending time in the water, Luiz loves music. He is a singer-songwriter who plays various instruments, including guitar, drums, bass, and piano. In his research, Luiz applies engineering tools to biology to build human tissues in the lab. The goal of Luiz's lab is to create new models to better understand cancers and develop methods to regenerate lost or damaged tissues. Luiz was awarded his Doctor of Dental Surgery (DDS) degree from the Pontifical Catholic University of Parana in Brazil. Afterwards, he conducted postdoctoral research at the University of California, San Francisco. He then enrolled in a graduate program and received his PhD in Biomaterials from the University of Sydney. Next he accepted a postdoctoral fellowship in Harvard Medical School and MIT's joint program in Health Sciences and Technology. He served on the faculty at the University of Sydney before joining the faculty at OHSU in 2015. His work on vascular bioprinting was listed in the top 100 research discoveries by Discover Magazine, and he has received over 30 national and international research awards, including the Medical Research Foundation New Investigator award, the Silver Family Faculty Innovation award, and many others. In this interview, Luiz shares more about his life and science.

Superpowers for Good should not be considered investment advice. Seek counsel before making investment decisions. When you purchase an item, launch a campaign or create an investment account after clicking a link here, we may earn a fee. Engage to support our work.Watch the show on television by downloading the e360tv channel app to your Roku, AppleTV or AmazonFireTV. You can also see it on YouTube.Devin: What is your superpower?Nicole: Willingness to take bold leaps and embrace the unknown.Imagine a world where cancer is as treatable as the flu. That's the vision Nicole Paulk, the founder and CEO of Siren Biotechnology, is working tirelessly to bring to life. Driven by groundbreaking science, Nicole's company is on the brink of launching clinical trials for a revolutionary cancer treatment.Nicole's work leverages engineered viruses—those that don't make you sick—to deliver genetic medicines directly to cancer cells. These “good viruses” act as a delivery system for anti-tumor drugs, targeting difficult-to-treat cancers like recurrent high-grade gliomas, a fatal brain cancer. “We started to see data that looked really promising in this space,” Nicole explained, adding, “We felt a moral obligation to go after this cancer where there's just this huge unmet need.”Siren Biotechnology's approach is designed to have broad applications. Unlike treatments that target specific genetic mutations, their method has the potential to work on various tumor types. Nicole describes it as using viruses like a “little FedEx delivery truck” that can be engineered to deliver medicine precisely where it's needed in the body.This innovation didn't happen overnight. Nicole, a former professor of virology at UCSF, took the bold step of leaving academia to launch Siren Biotechnology. “I decided to resign from my faculty position and go be the founder and CEO just because I was so excited about the data and what we had so far,” she shared.In addition to traditional venture capital funding, Siren Biotechnology is inviting the public to invest through a regulated investment crowdfunding campaign. This unique opportunity allows patients, families, and supporters touched by cancer to be part of their journey. “We wanted to bring patients and their families onto our cap table,” Nicole said. “It's a way to involve them in the conversation much earlier.”Siren Biotechnology's work could redefine cancer care and inspire a new model for patient-centered innovation. With clinical trials just months away, the future looks brighter for those battling cancer—and for all of us who dream of a world where cancer is no longer a death sentence.tl;dr:Nicole Paulk's Siren Biotechnology transforms viruses into targeted cancer therapies with universal potential.The company focuses on recurrent high-grade gliomas, a fatal brain cancer with no standard treatment.Nicole left academia to lead Siren, leveraging her groundbreaking virology research to launch the company.Siren's unique crowdfunding campaign lets patients and families invest in the fight against cancer.Nicole's superpower, fearless innovation, drives her bold mission to revolutionize cancer care.How to Develop Fearless Innovation As a SuperpowerNicole's superpower is her willingness to take bold leaps and embrace the unknown. After spending nearly two decades building her academic career, Nicole left her position as a virology professor at UCSF to start Siren Biotechnology. She explained, “I feel like my superpower is just kind of being willing to jump off the cliff without a parachute and be like, we're going to figure it out. We're going to make it work.”Nicole exemplified fearless innovation when her research led to a groundbreaking discovery about the biology of a virus, one that required rewriting existing textbooks. Initially met with skepticism, her work was later validated and became a foundation for Siren Biotechnology's cancer treatment. This pivotal moment highlights Nicole's courage to challenge conventional knowledge and pursue transformative ideas.Tips for Developing This Superpower:Be willing to question conventional wisdom and explore new paths.Take calculated risks, even if it means stepping away from a well-defined career path.Embrace discomfort and uncertainty as a necessary part of innovation.Engage others by communicating your vision in relatable and accessible ways.By following Nicole's example and advice, you can make fearless innovation a skill. With practice and effort, you could make it a superpower that enables you to do more good in the world.Remember, however, that research into success suggests that building on your own superpowers is more important than creating new ones or overcoming weaknesses. You do you!Guest ProfileNicole Paulk (she/her):CEO, Founder, President, Siren BiotechnologyAbout Siren Biotechnology: We are combining two transformative therapeutic technologies – AAV gene therapy and cytokine immunotherapy – into a single, reimagined modality that overcomes key challenges and redefines how we destroy tumor cells and elicit anti-tumor immunity.This is the first AAV gene therapy drug product that can be made once and used in numerous indications – a huge leap forward for the field. This drastically reduces clinical development times, manufacturing timelines, and capital needs for each clinical trial. Most importantly, ‘universal' means countless solid tumor cancer patients – regardless of tumor type or mutations – may benefit from this breakthrough approach.Website: sirenbiotechnology.comX/Twitter Handle: @SirenBioCompany Facebook Page: facebook.com/SirenBiotechnologyOther URL: wefunder.com/siren.biotechnologyBiographical Information: Dr. Nicole Paulk is the CEO, Founder, and President of Siren Biotechnology and has dedicated her career to advancing the field of gene therapy. With nearly two decades of expertise, Nicole has been at the forefront of developing cutting-edge advances to propel the field of gene therapy forward for a wide range of diseases.Before founding Siren, Nicole held various leadership positions in academia and industry and most notably was an Assistant Adj Professor of AAV Gene Therapy in the UCSF Department of Biochemistry & Biophysics before leaving to found Siren. Nicole has a B.S. in Medical Microbiology, a Ph.D. in Viral Gene Therapy and Regenerative Medicine from OHSU, and completed her Postdoctoral Fellowship and Instructorship in Human Gene Therapy at Stanford University prior to starting her lab at UCSF. Nicole is a pioneer in the development of next-generation AAV platforms for gene repair, gene transfer and gene editing, directed evolution for novel engineered capsid evolution, and comparative multi-omic approaches to interrogate translational AAV biology.Nicole is a renowned expert in gene therapy and has consulted extensively for big pharma, written draft CMC guidance for the FDA, and sits on the Scientific Advisory Boards for Sarepta, Astellas, Metagenomi, Dyno Therapeutics, CEVEC, GRO Biosciences, Excision BioTherapeutics, WhiteLab Genomics, Johns Hopkins Gene Therapy Initiative, the Gene Therapy for Rare Disorders Searchlight Program, and several stealth startups. She has been quoted in The Wall Street Journal, The Economist, The Boston Globe, Endpoints, STAT, Phacilitate, GEN, BioPharma Dive, Evaluate Vantage, SF Business Times, WIRED, Drug Discovery World, MIT Tech Review, C&EN, and more. She sits on the Scientific Editorial Boards of the journals Gene Therapy, Human Gene Therapy, and Biopharma International Gene Therapy. She is the Chair of the American Society of Gene and Cell Therapy (ASGCT) Translational Science Committee, and a member of the ASGCT Cancer Cell and Gene Therapy Committee and the Biocom California Cell and Gene Therapy Committee. She has invented numerous AAV gene therapy technologies that have been shared or licensed to dozens of gene therapy companies and nonprofit groups working in rare diseases.Outside of work, you can find Nicole adventure traveling (think whitewater rafting meets backcountry trekking), snowboarding, planning elaborate Halloween parties complete with animatronics and ghoulish menus, tending her vegetable garden, and obsessing over the latest wearable gadgets. If you're trying to track her down at a conference and can't find her, it's because she snuck off to an oyster bar.X/Twitter Handle: @Nicole_PaulkLinkedin: linkedin.com/in/nicolepaulkInstagram Handle: @sirenbioSupport Our SponsorsOur generous sponsors make our work possible, serving impact investors, social entrepreneurs, community builders and diverse founders. Today's advertisers include FundingHope, Kingscrowd and Crowdfunding Made Simple. Learn more about advertising with us here.Max-Impact MembersThe following Max-Impact Members provide valuable financial support:Carol Fineagan, Independent Consultant | Lory Moore, Lory Moore Law | Marcia Brinton, High Desert Gear | Paul Lovejoy, Stakeholder Enterprise | Pearl Wright, Global Changemaker | Ralf Mandt, Next Pitch | Scott Thorpe, Philanthropist | Matthew Mead, Hempitecture | Michael Pratt, Qnetic | Sharon Samjitsingh, Health Care Originals | Add Your Name HereUpcoming SuperCrowd Event CalendarIf a location is not noted, the events below are virtual.Impact Cherub Club Meeting hosted by The Super Crowd, Inc., a public benefit corporation, on June 17, 2025, at 1:00 PM Eastern. Each month, the Club meets to review new offerings for investment consideration and to conduct due diligence on previously screened deals. To join the Impact Cherub Club, become an Impact Member of the SuperCrowd.SuperCrowdHour, June 18, 2025, at 12:00 PM Eastern. Jason Fishman, Co-Founder and CEO of Digital Niche Agency (DNA), will lead a session on "How to Spin $1 of Advertising into $10!" He'll reveal proven strategies and marketing insights drawn from years of experience helping successful crowdfunding campaigns. Whether you're a founder planning a raise or a supporter of innovative startups, you'll gain actionable tips to boost visibility, drive engagement, and hit your funding goals. Don't miss it!Join us on June 25, 2025, at 8:00 PM Eastern for the Superpowers for Good Live Pitch—streaming on e360tv, where purpose-driven founders take the virtual stage to present their active Regulation Crowdfunding campaigns to a national audience of investors and changemakers. Selected startups are chosen for their commitment to community, alignment with NC3's Community Capital Principles, and their drive to create real-world impact. Thanks to sponsors DNA and DealMaker, this event is free to watch and amplifies the voices of underrepresented and mission-aligned entrepreneurs. Don't miss this inspiring evening where capital meets purpose—tune in to discover and support the next wave of impact-driven innovation.SuperCrowd25, August 21st and 22nd: This two-day virtual event is an annual tradition but with big upgrades for 2025! We'll be streaming live across the web and on TV via e360tv. Soon, we'll open a process for nominating speakers. Check back!Community Event CalendarSuccessful Funding with Karl Dakin, Tuesdays at 10:00 AM ET - Click on Events.Devin Thorpe is featured in a free virtual masterclass series hosted by Irina Portnova titled Break Free, Elevate Your Money Mindset & Call In Overflow, focused on transforming your relationship with money through personal stories and practical insights. June 8-21, 2025.Join Dorian Dickinson, founder & CEO of FundingHope, for Startup.com's monthly crowdfunding workshop, where he'll dive into strategies for successfully raising capital through investment crowdfunding. June 24 at noon Eastern. Regulated Investment Crowdfunding Summit 2025, Crowdfunding Professional Association, Washington DC, October 21-22, 2025.Call for community action:Please show your support for a tax credit for investments made via Regulation Crowdfunding, benefiting both the investors and the small businesses that receive the investments. Learn more here.If you would like to submit an event for us to share with the 9,000+ changemakers, investors and entrepreneurs who are members of the SuperCrowd, click here.We use AI to help us write compelling recaps of each episode. Get full access to Superpowers for Good at www.superpowers4good.com/subscribe

Dr. Adam Silberman is a naturopathic doctor and expert in anti-aging and regenerative medicine. Dr. Silberman brings over a decade of training and clinical experience to his patients and their families, specializing in the use of advanced lab work, diagnostic analysis, bioidentical hormone replacement therapy, antiaging peptide therapy, natural medicine, and ultrasound-guided joint injections to address disease and optimize health span. He earned his bachelor's in psychology from UCLA, his doctorate in natural medicine from Western University, and an MBA from Murdoch University in Perth, Australia. In this episode of Conversations for Health, we explore the work that he does to support men's health in their 50s and 60s to promote longevity and anti-aging into their final years. He shares a profile of his typical patient, how he organizes and utilizes collected patient data, and the strategies he has implemented to optimize each patient's integrated and supported in-office experience.  He generously shares his approach to aggregating client data for a holistic snapshot, the key metrics and trends that are tracked on every client, and his approach to men's health that utilizes naturopathic medicine, supplements, and preventative lifestyle changes that support longevity and antiaging in men.    I'm your host, Evelyne Lambrecht, thank you for designing a well world with us.   Episode Resources: Dr. Adam Silberman:  https://www.blueprintwellness.org/ Design for Health Resources: Designs for Health - https://www.designsforhealth.com/ Designs for Health Practitioner Exclusive Drug Nutrient Depletion and Interaction Checker - https://www.designsforhealth.com/drug-nutrient-interaction/ Visit the Designs for Health Research and Education Library, which houses medical journals, protocols, webinars, and our blog. https://www.designsforhealth.com/research-and-education/education The Designs for Health Podcast is produced in partnership with Podfly Productions. Chapters: 00:00 Intro. 02:39 Dr. Adam is feeling lit up about early morning soccer games with his kids.  04:00 Adam's bittersweet desire to pursue naturopathic medicine. 10:12 A profile of Adam's current patient.  15:55 Task Force Dagger and specialized programming for first responders.  17:50 Supporting athletes during the off-season.  20:52 Organizing and utilizing collected patient data.  26:02 Optimizing and integrating each client's high-touch experience.  27:10 Aggregating client data for a holistic snapshot.  29:30 Key metrics and trends that are tracked on every client.  36:57 The case for full-body MRIs and DEXA scans.  40:05 Noted differences between CoreViva and other scans.  44:30 HRV and adrenal stress index, and strategies for increasing HRV.  47:35 Dr. Adam's favorite supplements, particularly adaptogens. 50:32 Meeting the increasing demand for focus on men's health.  55:44 Addressing the underlying causes of decreased testosterone.  1:05:01 One thing Dr. Adam does with every male patient.  1:06:22 Dr. Adam's favorite personal supplements, favorite health practices, and his changed view on the use of appropriate pharmaceutical interventions. 

Dr. Erica Lacher is a 2001 graduate of the University of Florida's College of Veterinary Medicine, and the owner of Springhill Equine Veterinary Clinic in Newberry, Florida. In addition to practicing medicine, she is also an author, blogger, and podcaster, with the mission of making the world a better place for horses. Her podcast, Straight from the Horse Doctor's Mouth, is popular among horse owners worldwide. She enjoys competing in show jumping with her horses, and spending time outdoors with her husband.

Dr. Maneesha Inamdar is the Director of the Institute for Stem Cell Science and Regenerative Medicine and Professor at Jawaharlal Nehru Centre for Advanced Scientific Research. Her lab uses comparative models, including mice, Drosophila, stem cell lines, and gastruloids, to study developmental biology. She talks about using embryo models to investigate teratogenicity, prioritizing ethnically diverse cell lines, and representing Indian scientists in global discussions.

 This episode is brought to you by Timeline, Pique Teas, Caldera Lab, and LMNT. Dr. Joy Kong, MD is a UCLA-trained, triple board-certified physician and is here today to scientifically and succinctly explain the transformative potential of stem cells therapy. Dr. Kong delves into the multifaceted applications of stem cells, particularly in treating autoimmune disorders, cancer, and enhancing overall longevity. She provides insight into how stem cells can optimize mitochondrial function, immune modulation, and potentially slow the aging process. She also bridges Western and Chinese medical philosophies, emphasizing a holistic approach to health. Ethical and regulatory considerations surrounding stem cell therapy are discussed, with Dr. Kong addressing common misconceptions about the safety and legality of these treatments.  Follow Joy @dr_joy_kong Follow Chase @chase_chewning ----- In this episode we discuss... (00:00) Stem Cells and Regenerative Medicine (06:47) Expanding Healthcare Beyond Specialties (17:09) What is the Real Potential of Stem Cells? (29:35) Aging, Stem Cells & Longevity (44:06) Stem Cells for Men's Health (53:35) Optimizing Stem Cell Therapy Approaches (01:08:05) Stem Cell Therapy Safety and Regulation (01:21:04) Cost and Ethics (01:27:51) Stem Cell Therapy Exploration (01:33:22) Ever Forward ----- Episode resources: Get a FREE 3-day sample pack of MitoPure gummies at https://www.Timeline.com/everforwardsample  Get 20% off for life of Pu'er teas at https://www.PiqueLife.com/everforward  Get dad the gift of good skin this Father's Day with 20% off any skincare product with code EVERFORWARD at https://www.CalderaLab.com  Get the limited edition electrolyte flavor Lemonade Salt and a FREE variety sample pack with any purchase at https://www.DrinkLMNT.com/everforward  Watch and subscribe on YouTube Learn more at JoyKongMD.com

Dr. Anne Truong is a board-certified physician with over 20 years of clinical experience and a trailblazer in the field of regenerative medicine and men's sexual health. Known for her outside-the-box approach, she helps patients heal the cause of sexual dysfunction—not just mask the symptoms. Through her practice, Dr. Anne has helped countless individuals reclaim their vitality, confidence, and quality of life. Her patients, lovingly called “Vitality Warriors,” trust her integrative, patient-centered methods that blend cutting-edge regenerative therapies with nutrition, hormone balancing, lifestyle support, and deep education.

What if hair loss and sexual dysfunction weren't just signs of aging—but signals your body needs deeper healing?In this episode, Dr. Joy Kong sits down with Dr. Shivani Amin, a specialist at Chara Health, where she leads our work in hair restoration and sexual wellness. Together, they dive into how stem cells, exosomes, and peptides can rejuvenate the body from the inside out—helping patients feel and look their best.Dr. Amin explains how her personalized, root-cause approach at Chara Health delivers real results for both men and women, and why combining regenerative therapies with energy medicine is the future of healing.If you're seeking support for hair loss, low libido, or whole-body vitality, this episode shows what's possible at Chara Health.More on Dr. Shivani Amin:Website: https://www.drshivaniamin.com/Instagram: https://www.instagram.com/drshivaniamin/?hl=en--Additional Resources:Visit My Clinic: Chara Health

Subscribe to the video podcast: https://www.youtube.com/@DrTazMD/podcastsStem cell therapy is transforming regenerative medicine, offering powerful treatments for chronic inflammation, aging, autism, and more. In this eye-opening interview, triple board-certified physician Dr. Joy Kong reveals how stem cells work, why they're more than just anti-aging tools, and how DNA and energy-based healing could be the future of healthcare.You'll learn how IV stem cell therapy works, how to avoid dangerous clinics, and why stem cells are revolutionizing treatment for autoimmune conditions, mental health, and skin and hair rejuvenation. Dr. Kong also shares her journey from psychiatry to founding the American Academy of Integrative Cell Therapy.This episode covers the powerful regenerative potential of stem cells, the rise of IV therapy, how to avoid unregulated clinics, and why true healing must always be holistic. Whether you're seeking answers for chronic illness or curious about the future of longevity, this is a must-watch.Connect further to Hol+ at https://holplus.co/- Don't forget to like, subscribe, and hit the notification bell to stay updated on future episodes of hol+.About Dr. Joy Kong:Dr. Joy Kong is a triple board-certified anti-aging physician and stem cell specialist, renowned for her expertise in stem cell therapy and commitment to educating both physicians and the public. With a strong presence in the industry, she has established herself as a trusted voice through her extensive lecturing at national and international conferences, as well as her publications in scientific journals.As a dedicated educator and pioneer in the field of regenerative medicine, Dr. Kong has founded the American Academy of Integrative Cell Therapy (AAICT) and trained numerous physicians from around the world. Her innovative approach has also led to the creation of Chara Health USA and Chara Biologics, premier companies providing cutting-edge products and services to patients across the United States. With numerous accolades, including Stem Cell Doctor of the Year and Stem Cell Doctor of the Decade, Dr. Kong continues to be a respected figure in the medical community, dedicated to advancing the field of regenerative medicine and improving patient outcomes through her emphasis on scientific data, passion, authenticity, and integrity.Her inspiring memoir, "Tiger of Beijing," which recounts her remarkable journey as an immigrant from China at the age of 20 starting with her visa rejection in 1991, was named 2020 Book of the Year by IAOTP.Stay ConnectedSubscribe to the audio podcast: https://holplus.transistor.fm/subscribeSubscribe to the video podcast: https://www.youtube.com/@DrTazMD/podcastsFollow Dr. Taz on Instagram: https://www.instagram.com/drtazmd/https://www.instagram.com/liveholplus/Join the conversation on X: https://x.com/@drtazmdTikTok: https://www.tiktok.com/@drtazmdFacebook: https://www.facebook.com/drtazmd/Follow Dr. Kong on Instagram:https://www.instagram.com/dr_joy_kong/Host & Production TeamHost: Dr. Taz; Produced by Rainbow Creative (Executive Producer: Matthew Jones; Lead Producer: Lauren Feighan; Editors: Jeremiah Schultz and Patrick Edwards)Don't forget to like, subscribe, and hit the notification bell to stay updated on future episodes of hol+01:58 - Dr. Joy Kong's Journey into Regenerative Medicine  03:30 - Stem Cell Therapy for Autism and Chronic Conditions  05:15 - Inside the American Academy of Integrative Cell Therapy  08:14 - Stem Cells as Energy and DNA-Based Healing  12:31 - How Stem Cells Navigate the Body and Target Inflammation  16:36 - Umbilical vs. Fat-Derived Stem Cells: Safety and Sourcing  20:53 - Avoiding Stem Cell Scams: Testing, Regulations, and Red Flags  26:53 - IV Stem Cell Therapy: Benefits, Applications, and Costs  43:24 - Stem Cells for Skin, Hair Loss, and Anti-Aging Results

In this episode of the Veterinary Cancer Pioneers Podcast, host Dr. Rachel Venable welcomes Dr. Steve Dow, professor of immunology at Colorado State University and Director of the Center for Immune and Regenerative Medicine. Dr. Dow shares insights from his groundbreaking work on myeloid-targeted immunotherapies and the innovative use of repurposed, FDA-approved drugs like losartan, palladia, and propranolol in treating canine cancers such as osteosarcoma and brain tumors. He also discusses the development of tumor vaccines, promising adjuvant trial results, and the critical role dogs play as translational models in advancing human cancer therapies. The episode highlights the future potential of bispecific antibodies and CAR-T cell therapies in both veterinary and human oncology.

In this cutting-edge episode of Stop Aging Now, Dr. Nick Delgado teams up with renowned integrative medicine expert Dr. Alex Paziotopoulos to explore the latest breakthroughs in health, wellness, and regenerative medicine. From stem cell therapy to advanced hormonal optimization and anti-inflammatory protocols, this conversation dives deep into the science of healing, longevity, and peak performance. Discover the future of medicine today—where prevention meets precision and aging is no longer inevitable.

In this engaging conversation, intimacy expert Susan Bratton discusses the profound connection between mastering intimacy and achieving high performance in various aspects of life. She emphasizes that sexual skills are learned and that pleasure is essential for overall health and happiness. The discussion also explores the impact of technology on sexual experiences, the importance of oxytocin in relationships, and the evolving dynamics of gender and sexuality in contemporary society. Bratton encourages continuous learning and exploration in intimacy to enhance personal and relational well-being.Chapters00:00 Mastering Intimacy for High Performance03:01 The Connection Between Health and Sexuality05:52 Learning and Skills in Sexuality08:58 The Importance of Continuous Learning in Intimacy11:58 Exploring New Techniques and Tools14:52 Regenerative Medicine and Longevity17:51 Oxytocin and Its Role in Connection28:59 Overcoming Health Challenges33:13 Strength, Fitness, and Aging Gracefully34:12 Gaining Wisdom Through Experience37:09 The Intersection of Sexuality and Health39:09 Repression and Control in Sexuality40:10 Shifting Paradigms in Relationships46:17 The Future of Sex and Technology

Dr. Margaret "Peggy" Goodell is the Vivian L. Smith Chair in Regenerative Medicine and Director of the Stem Cell and Regenerative Medicine Center at Baylor College of Medicine. Her research focuses on HSC regulation and aging. She talks about her discovery of a side population of HSCs, as well as her work on DNMT3A mutation and clonal hematopoiesis of indeterminate potential. Finally, she discusses the rich research environment in Houston.

Most people assume that aging means inevitable decline—but health and mindset can tell a different story. At 53, Steven Kotler set out to defy the so-called “long slow rot” of aging by learning how to park ski, a feat most experts believed was biologically impossible past 35. Along the way, he uncovered that many of our mental and physical abilities are “use-it-or-lose-it” skills—ones we can actively train to extend performance, youthfulness, and joy. In this episode, Steven shares the science behind peak performance aging, how mindset shapes longevity, and why dynamic challenges like action sports may be the secret to staying young and profiting. In this episode, Hala and Steven will discuss: (00:00) Introduction (01:22) The Inspiration Behind Studying Peak Performance (02:25) Debunking the Long Slow Rot Theory (04:16) Use It or Lose It: Physical Skills (06:54) The Importance of Dynamic Activities (16:57) Mindset and Aging (21:29) Overcoming Personal Traumas (27:59) Fluid vs. Crystallized Intelligence (32:43) Advancements in Regenerative Medicine (34:07) Learning and Cognitive Health (34:52) Three Types of Thinking for Better Aging (35:42) Business Opportunities in Hiring Older Adults (37:20) The Importance of Physical and Mental Activity (42:07) The Power of Authentic Learning (50:51) Insights from the Blue Zones (56:33) The Role of Flow in Aging and Performance Steven Kotler is a New York Times bestselling author, an award-winning journalist, and the Executive Director of the Flow Research Collective. He is one of the world's leading experts on human performance. Steven is the author of 11 bestsellers (out of fourteen books), including The Art of Impossible and The Future is Faster Than You Think. His work has been nominated for two Pulitzer Prizes, translated into over 50 languages, and has appeared in over 100 publications, including the New York Times Magazine, Wired, Atlantic Monthly, Wall Street Journal, TIME, and the Harvard Business Review. In his latest book, Gnar Country: Growing Old, Staying Rad, Steven tests his knowledge and theories on his own aging body in a quest to become an expert skier at age 53. Sponsored By: Indeed - Get a $75 sponsored job credit at indeed.com/profiting Shopify - Sign up for a one-dollar-per-month trial period at youngandprofiting.co/shopify Microsoft Teams - Stop paying for tools. Get everything you need, for free at aka.ms/profiting Mercury - Streamline your banking and finances in one place. Learn more at mercury.com/profiting OpenPhone: Streamline and scale your customer communications with OpenPhone. Get 20% off your first 6 months at openphone.com/profiting Mercury - Streamline your banking and finances in one place. Learn more at mercury.com/profiting  Airbnb - Find yourself a co-host at airbnb.com/host Active Deals - youngandprofiting.com/deals       Key YAP Links Reviews - ratethispodcast.com/yap  Youtube - youtube.com/c/YoungandProfiting  LinkedIn - linkedin.com/in/htaha/  Instagram - instagram.com/yapwithhala/  Social + Podcast Services - yapmedia.com   Transcripts - youngandprofiting.com/episodes-new  Entrepreneurship, entrepreneurship podcast, Business, Business podcast, Self Improvement, Self-Improvement, Personal development, Starting a business, Strategy, Investing, Sales, Selling, Psychology, Productivity, Entrepreneurs, AI, Artificial Intelligence, Technology, Marketing, Negotiation, Money, Finance, Side hustle, Startup, mental health, Career, Leadership, Mindset, Health, Growth mindset, Mental Health, Health, Psychology, Wellness, Biohacking, Motivation, Mindset, Manifestation, Productivity, Brain Health, Life Balance, Self Healing, Positivity, Happiness, Sleep, Diet

Revolutionizing Regenerative Medicine: The Power of Mass-Produced Mitochondria: Nutritionist Leyla Muedin explores groundbreaking research on stem cell-based methods to mass-produce human mitochondria, which could revolutionize regenerative and anti-aging medicine. She delves into the science and potential health benefits, discussing how increased mitochondrial production can improve conditions like osteoarthritis, heart disease, and neurodegenerative disorders. Leyla also provides practical advice on ways to enhance mitochondrial health through dietary and supplement strategies, offering listeners actionable steps to boost their health span and lifespan.

In this episode of the Boost Your Biology podcast, host Lucas Aoun interviews Dr. Joy Kong, a UCLA-trained physician specializing in psychiatry, addiction medicine, and regenerative medicine. Dr. Kong shares her journey from China to the U.S., her fascination with both Eastern and Western medicine, and her awakening to the potential of stem cell therapy. She discusses the complexities of autism treatment, the myths surrounding stem cell therapy, and the advantages of using umbilical cord-derived stem cells for regenerative purposes. In this conversation, Dr. Joy Kong discusses the impact of age on stem cells, the benefits of umbilical cord-derived stem cells in cancer treatment, and the importance of complementary products like amino acids and fulvic acid in enhancing stem cell therapy. She also explores the future of mobile stem cell treatments, the need for more research in mental health and neurodegenerative conditions, and the potential of peptides and energy therapy in optimizing health. Dr. Kong emphasizes the importance of making medicine enjoyable and accessible, while also educating patients about the tools available for their health.Relevant links:Joy's website: https://joykongmd.com/ The Hottest New Supplement Here: https://www.inb4supps.com/ Disclaimer:The information provided in this podcast episode is for entertainment purposes and is NOT MEDICAL ADVICE. If you have any questions about your health, contact a medical professional. This content is strictly the opinions of Lucas Aoun and is for informational and entertainment purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult with their doctors or qualified health professionals regarding specific health questions. Neither Lucas Aoun nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this content. All consumers of this content especially taking prescription or over-the-counter medications should consult their physician before beginning any nutritional, supplement or lifestyle program. Hosted on Acast. See acast.com/privacy for more information.

Join our community of fearless leaders in search of unreasonable outcomes... Want to become a FEARLESS entrepreneur and leader? Go here: https://books.ryanhanley.com Watch on YouTube: https://link.ryanhanley.com/youtube Master of the Close - Learn how to scale your sales process, fast: https://link.ryanhanley.com/masteroftheclose Dr Joy Kong Website: https://joykongmd.com/ Instagram: https://www.instagram.com/dr_joy_kong/ In this episode, Ryan Hanley sits down with Dr. Joy Kong, A board-certified physician, regenerative medicine expert, and president of Chara Health (formerly Uplyft Longevity Center) in Los Angeles. Dr. Kong specializes in cutting-edge therapies including stem cell therapy, ketamine therapy, and a wide range of holistic modalities aimed at enhancing the body's innate regenerative power. Together, they dive deep into the truth about regenerative medicine, demystify stem cells, explore the root cause of aging and chronic disease, inflammation, and discuss how therapies like peptides, NAD, and light treatments can optimize performance and longevity. Dr. Kong also shares remarkable real-world outcomes from her clinic, including cases of vision restoration and liver disease reversal. As the founder of the American Academy of Integrative Cell Therapy, Dr. Kong is passionate about educating both physicians and the public on the science and safety of stem cell medicine. She strongly advocates for high-quality clinical research and is the lead investigator in an ongoing traumatic brain injury (TBI) study. Her work has been published in peer-reviewed scientific journals. Check Out Our Sponsors OpusClip: #1 AI video clipping and editing tool: https://link.ryanhanley.com/opus Riverside: HD Podcast & Video Software | Free Recording & Editing: https://link.ryanhanley.com/riverside Shortform - The World's Best Book Summaries: https://link.ryanhanley.com/shortform Taplio • Grow Your Personal Brand On LinkedIn: https://link.ryanhanley.com/taplio Kit: Email-First Operating System for Creators (formerly ConvertKit): https://link.ryanhanley.com/kit

Join our community of fearless leaders in search of unreasonable outcomes... Want to become a FEARLESS entrepreneur and leader? Go here: https://books.ryanhanley.com Watch on YouTube: https://link.ryanhanley.com/youtube Master of the Close - Learn how to scale your sales process, fast: https://link.ryanhanley.com/masteroftheclose Dr Joy Kong Website: https://joykongmd.com/ Instagram: https://www.instagram.com/dr_joy_kong/ In this episode, Ryan Hanley sits down with Dr. Joy Kong, A board-certified physician, regenerative medicine expert, and president of Chara Health (formerly Uplyft Longevity Center) in Los Angeles. Dr. Kong specializes in cutting-edge therapies including stem cell therapy, ketamine therapy, and a wide range of holistic modalities aimed at enhancing the body's innate regenerative power. Together, they dive deep into the truth about regenerative medicine, demystify stem cells, explore the root cause of aging and chronic disease, inflammation, and discuss how therapies like peptides, NAD, and light treatments can optimize performance and longevity. Dr. Kong also shares remarkable real-world outcomes from her clinic, including cases of vision restoration and liver disease reversal. As the founder of the American Academy of Integrative Cell Therapy, Dr. Kong is passionate about educating both physicians and the public on the science and safety of stem cell medicine. She strongly advocates for high-quality clinical research and is the lead investigator in an ongoing traumatic brain injury (TBI) study. Her work has been published in peer-reviewed scientific journals. Check Out Our Sponsors OpusClip: #1 AI video clipping and editing tool: https://link.ryanhanley.com/opus Riverside: HD Podcast & Video Software | Free Recording & Editing: https://link.ryanhanley.com/riverside Shortform - The World's Best Book Summaries: https://link.ryanhanley.com/shortform Taplio • Grow Your Personal Brand On LinkedIn: https://link.ryanhanley.com/taplio Kit: Email-First Operating System for Creators (formerly ConvertKit): https://link.ryanhanley.com/kit

In this episode of the Spectrum of Health podcast, Dr. Christine Schaffner shares key insights from her recent presentations at leading health conferences. She explores the growing recognition of mast cell activation as a major health issue and highlights the innovative role of peptides and exosomes in treatment. Dr. Schaffner also discusses the significance of addressing cancer stem cells and the deeper root causes behind mast cell activation, offering a forward-thinking perspective on healing and clinical care. For the full show notes please visit my website: https://www.drchristineschaffner.com/Episode286