Podcasts about Medical research

Featuring articles on pulmonary arterial hypertension, oral semaglutide and cardiovascular outcomes, giant-cell arteritis, the loss of subsidized drug coverage and mortality, and neutralizing venom toxins; a review article on cancer of unknown primary site; a case report of a man with fever, nausea, and respiratory failure; and Perspectives on primary care and the free market, federal cuts at the VA, the GINA gap, and the meaning of goodbye.

Doctors in the US have become the first to treat a baby with a customised gene-editing therapy after diagnosing the child with a severe genetic disorder that kills about half of those affected in early infancy. Ian Sample explains to Madeleine Finlay how this new therapy works and how it paves the way for even more complex gene editing techniques. David Liu, a professor at the Broad Institute of MIT and Harvard and the inventor of these therapies, also describes the barriers that could prevent them reaching patients, and how he thinks they can be overcome. Help support our independent journalism at theguardian.com/sciencepod

In this week's episode we'll learn about how frequent blood donation affects clonal hematopoiesis in older, male blood donors; the effect of immune microenvironment on response to bispecific antibodies in diffuse large B-cell lymphoma; and the feasibility of adding blinatumomab to early consolidation therapy in CD19-positive Ph-negative B-cell acute lymphoblastic lymphoma.Featured ArticlesClonal Hematopoiesis Landscape in Frequent Blood DonorsIntegrative genomic analysis of DLBCL identifies immune environments associated with bispecific antibody responseUpfront Blinatumomab Improves MRD Clearance and Outcome in Adult Ph-negative B-lineage ALL: The GIMEMA LAL2317 Phase 2 Study

In part two of the How I Treat Series on Transfusion Medicine Dr. Erica Wood interviews the "How I Manage Major Hemorrhage" author group: Drs. Jeannie Callium, Keyvan Karkouti, and Ron George.Find the full published review series in Volume 145 Issue 20 of Blood Journal.

Some call it your sixth sense. You refer to it when you have a “gut feeling.” With a vast fiber network running throughout your body, the vagus nerve knows about and helps regulate every critical function in it, from heart rate to digestion to your immune system. Now bioelectric medicine is tapping into that bodily omniscience by using tiny electrical pulses on the vagus nerve to help treat diseases as diverse as epilepsy, diabetes, stroke, Parkinson's, and even depression. In the coming months, the FDA is set to make a decision about a vagus nerve stimulation device, which, if approved, could provide first-of-its-kind treatment for an autoimmune disease that affects millions of Americans. We consider the groundbreaking potential of vagus nerve stimulation and ask whether electricity could one day replace medications. Guest: Kevin Tracey – Neurosurgeon, president of the Feinstein Institutes for Medical Research at Northwell Health, and author of “The Great Nerve: The New Science of the Vagus Nerve and How to Harness Its Healing Reflexes”  Featuring music by Dewey Dellay and Jun Miyake You can get early access to ad-free versions of every episode by joining us on Patreon. Thanks for your support! Big Picture Science is part of the Airwave Media podcast network. Please contact advertising@airwavemedia.com to inquire about advertising on Big Picture Science. Learn more about your ad choices. Visit megaphone.fm/adchoices

Immunologist Dr Michelle Linterman is a Program leader at the Malaghan Institute of Medical Research. 

Today on The Shawn Bolz Show: Bold Shifts in Healthcare & Faith

In this week's episode, we'll learn about stopping myeloma maintenance therapy in the modern era. New research suggests that many patients in remission can discontinue lenalidomide, remaining treatment-free, without jeopardizing disease response. After that: a novel congenital neutropenia syndrome. Mutations in the COPZ1 gene impact myeloid differentiation and development of neutropenia. Researchers describe the mechanisms and propose a treatment strategy for restoring granulopoiesis. Finally, ruxolitinib maintenance therapy after allogeneic transplant. In a phase 2 study, this treatment strategy was associated with low rates of chronic graft-versus-host disease. Investigators say the use of JAK inhibitors in this context warrants further study.Featured Articles: Sustained bone marrow and imaging MRD negativity for 3 years drives discontinuation of maintenance post-ASCT in myelomaA new severe congenital neutropenia syndrome associated with autosomal recessive COPZ1 mutationsLow rates of chronic graft-versus-host disease with ruxolitinib maintenance following allogeneic HCT

In this two-part series, Dr. Erica Wood talks with Drs. Masja de Haas, Helen Savoia, and Stella Chou about their articles in the How I Treat Series on Transfusion Medicine. Topics include noninvasive prenatal testing for red blood cell and platelet antigens, transfusion cases in sickle cell disease, and pregnant patients who are alloimmunized to RBC antigens. Find the full published review series in Volume 145 Issue 20 of Blood Journal.

In medicine, failure can be catastrophic. It can also produce discoveries that save millions of lives. Tales from the front line, the lab, and the I.T. department. SOURCES:Amy Edmondson, professor of leadership management at Harvard Business School.Carole Hemmelgarn, co-founder of Patients for Patient Safety U.S. and director of the Clinical Quality, Safety & Leadership Master's program at Georgetown University.Gary Klein, cognitive psychologist and pioneer in the field of naturalistic decision making.Robert Langer, institute professor and head of the Langer Lab at the Massachusetts Institute of Technology.John Van Reenen, professor at the London School of Economics. RESOURCES:Right Kind of Wrong: The Science of Failing Well, by Amy Edmondson (2023).“Reconsidering the Application of Systems Thinking in Healthcare: The RaDonda Vaught Case,” by Connor Lusk, Elise DeForest, Gabriel Segarra, David M. Neyens, James H. Abernathy III, and Ken Catchpole (British Journal of Anaesthesia, 2022)."Estimates of preventable hospital deaths are too high, new study shows," by Bill Hathaway (Yale News, 2020).“Dispelling the Myth That Organizations Learn From Failure,” by Jeffrey Ray (SSRN, 2016).“A New, Evidence-Based Estimate of Patient Harms Associated With Hospital Care,” by John T. James (Journal of Patient Safety, 2013).To Err is Human: Building a Safer Health System, by the National Academy of Sciences (1999).“Polymers for the Sustained Release of Proteins and Other Macromolecules,” by Robert Langer and Judah Folkman (Nature, 1976).The Innovation and Diffusion Podcast, by John Van Reenen and Ruveyda Gozen. EXTRAS:"The Curious, Brilliant, Vanishing Mr. Feynman," series by Freakonomics Radio (2024).“Will a Covid-19 Vaccine Change the Future of Medical Research?” by Freakonomics Radio (2020).“Bad Medicine, Part 3: Death by Diagnosis,” by Freakonomics Radio (2016).

Featuring articles on multiple sclerosis, narcolepsy type 1, antiretroviral therapy in children with HIV, and porcine kidney xenotransplantation; a review article on Ph-positive acute lymphoblastic leukemia; a case report of a woman with peritonsillar swelling and bleeding; and Perspectives on the power of physicians in dangerous times, on community health centers, on AI-driven clinical documentation, and on driving Jackson.

For a long time the appendix was considered disposable. After all, millions of people have theirs removed each year and go on to live healthy lives. But as Heather F Smith, a professor of anatomy at Midwestern University tells Ian Sample, researchers are increasingly understanding what this small worm-shaped organ may be bringing to the table in terms of our health. Smith explains how the appendix is linked to both our immune system development and gut health, and why she thinks an increasing interest in the microbiome may bring it to greater prominence. Help support our independent journalism at theguardian.com/sciencepod

In this episode, Dr. Kayla Osterhoff shares her unique journey from physical therapy to women's health advocacy, driven by personal experiences with the medical system's failures regarding women's health. She discusses the significant gender bias in medical research, highlighting the lack of female representation in studies and the implications this has on women's health outcomes.   Dr. Osterhoff and Dr. Smeaton also discuss: Historical context for the ongoing issues of gender bias in science and medicine Hormonal influences on mental health  The importance of understanding the female biorhythm  The intricate relationship between the menstrual cycle, hormonal changes, and their impact on women's physical and cognitive performance  How understanding these cycles can help optimize health and performance, particularly during different phases of the menstrual cycle  Show Notes: Learn more about Dr. Osterhoff's company focused on closing the gender gap in science, Her Biorhythm, and follow her on Instagram @dr.kaylaosterhoff! Explore how the DUTCH Test can profoundly change the lives of your patients by becoming a DUTCH Provider today. 

Pradeep Khosla is the chancellor of UC San Diego and a nationally recognized voice on the evolving role of public research universities. Under his leadership, UC San Diego has doubled in size, broadened its access, and transformed from a "diamond in the rough" into a globally respected powerhouse for innovation, education, and the arts. He spearheaded the expansion of student housing—growing UC San Diego's housing program into the second largest in the nation—to make college more affordable and accessible for thousands. Chancellor Khosla brings a strategic, inclusive lens to higher ed. This Episode:  What should the modern public university look like and who should it serve? In this episode of Stop & Talk, host Grant Oliphant and co-host Crystal Page sit down with Pradeep Khosla, Chancellor of UC San Diego, to discuss the transformational growth and philosophy behind one of the nation's top public universities. Chancellor Khosla offers an expansive view on the role of public research universities in society—from economic impact to cultural integration and educational access. With a focus on abundance over scarcity, Chancellor Khosla explains how UC San Diego has evolved into a national leader in both science and the arts, investing in student housing, public transit access, and downtown engagement. He also reflects on the challenges of leading through federal uncertainty, advocating for research funding, and shaping an inclusive institution that belongs to the community it serves. Key Moments: [3:20] From Pittsburgh to La Jolla – Why Chancellor Khosla came to UC San Diego and what he saw in its untapped potential. [6:05] Elite, Not Elitist – How UC San Diego is challenging the notion that exclusivity equals excellence in higher education. [21:30] Universities as Economic Engines – Why public research institutions are essential to regional prosperity and innovation. [27:30]  Housing is Access – How UCSD is addressing affordability by building one of the largest student housing programs in the country.  [37:40] The Importance of the Arts – The value of connecting the arts to education and community Resources Mentioned in This Episode: UC San Diego Park & Market – A cultural and academic hub in downtown San Diego The Depot – UCSD's newly purchased multidisciplinary arts incubator and cultural hub in Downtown San Diego San Diego Light Rail – Connecting communities to the UCSD campus Take Action: Attend Events at Park & Market: Explore arts, lectures, and public programming in downtown SD. Visit UC San Diego: From the Birch Aquarium to campus cultural events, UCSD is open to all. Support Public Education & Research: Advocate for research funding and equitable higher ed access. Connect with the Arts: Engage with programs at The Depot and La Jolla Playhouse. Explore Philanthropy: Consider supporting educational initiatives that expand opportunity. 

In this week's episode, we'll learn more about how measurable residual disease might help guide decisions about post-transplant gilteritinib maintenance in FLT3-ITD acute myeloid leukemia, or AML; how stemness contributes to chemotherapy resistance in AML; and effects of babesiosis on red blood cells from individuals with sickle cell disease, sickle cell trait, and wild-type hemoglobin. Featured Articles:Measurable residual disease and post-transplantation gilteritinib maintenance for patients with FLT3-ITD-mutated AML GATA2 links stemness to chemotherapy resistance in acute myeloid leukemia Babesiosis and Sickle Red Blood Cells: Loss of Deformability, Heightened Osmotic fragility and Hyper-vesiculation 

Featuring articles on high-risk smoldering multiple myeloma, M. tuberculosis infection, type 2 diabetes, uncontrolled hypertension, and lymphoma; a review article on the chemistry of food; a case report of a man with weight loss, weakness, and anorexia; and Perspectives on the dismantling of foreign-assistance efforts, on the crushing weight of nonclinical demands in primary care, and on the last dose.

Scientific Sense ® by Gill Eapen: Prof. Kevin Tracey is Professor of Molecular Medicine and Neurosurgery at Hofstra/Northwell. He is also the CEO of Feinstein Institutes for Medical Research. His latest book is Great Nerve. Please subscribe to this channel:https://www.youtube.com/c/ScientificSense?sub_confirmation=1

On this episode of JHLT: The Podcast, the Digital Media Editors invite first author Peter Cho and senior author Abbas Ardehali, MD, to discuss the paper, “Severe primary graft dysfunction in heart transplant recipients using donor hearts after circulatory death: a United States Experience.” Peter is a third year medical student at Drexel University, and Dr. Ardehali is professor of surgery and medicine and the Director of the Heart, Lung, and Heart-Lung Transplant programs at UCLA. The episode explores: The study's findings regarding an increased incidence of severe PGD at 24 hours post-transplant in DCD over DBD recipients What risks weren't changed in DCD recipients—suggesting that DCD PGD is likely to be transient, and may have a different phenotype How NRP may impact the outcomes Mitigating the risk of PGD For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt. Tune in again later this month for the Digital Media Editors' findings and observations from the ISHLT2025 Annual Meeting in Boston. Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

In this episode of Passing Judgment, host Jessica Levinson speaks with NPR's Elissa Nadworny to unpack the Trump administration's efforts to withhold federal funding from colleges and universities over issues like antisemitism and DEI practices. They discuss how these unprecedented moves are impacting not campus life, but vital medical and scientific research nationwide. Elissa explains the legal challenges schools like Harvard are mounting in response, the stakes involved for the entire higher education sector, and the broader implications for public policy.Here are three key takeaways you don't want to miss:Federal Funding as a Lever in Higher Education Policy: The episode opens by surveying recent actions from the Trump administration regarding federal funding for colleges and universities. The administration is using financial levers—pausing, freezing, or cutting funds—to influence policies on campus, particularly tied to issues like DEI (diversity, equity, and inclusion) and antisemitism. Mechanisms and Legality of Federal Control: The speakers discuss how and why the administration has the power to control this funding. The complexities of federal funding—who controls the purse strings, when Congress vs. the executive branch has authority, and what legal mechanisms are at play—come up. The episode highlights that while presidents can make funding conditional, the legality often hinges on whether proper procedures are followed (Administrative Procedures Act), not just on broad authority.Who Really Loses When Funds Are Cut: The speakers emphasize that federal research dollars are not just about student amenities—they fund major scientific, medical, and technological research. The implications of large-scale cuts ripple well beyond campuses, potentially hurting national health, technological innovation, and local economies (since universities are major employers and research hubs).Follow Our Host: @LevinsonJessica

Direct to consumer tests that claim to tell us our biological – as opposed to chronological – age are getting a lot of attention, but what can they really tell us about our health? Science editor Ian Sample talks to Dr Brian H Chen, an epidemiologist at the California Pacific Medical Center Research Institute, who has conducted research into a variety of these tests called epigenetic clocks. He explains what exactly they are measuring and whether, once we have the results, there are any evidence-based strategies we can adopt to lower our biological age. Help support our independent journalism at theguardian.com/sciencepod

Sponsored by: Set for LifeSet For Life Insurance helps doctors safeguard their future with True Own Occupational Disability Insurance. A single injury or illness can change everything, but the best physicians plan ahead. Protect your income and secure your future before life makes the choice for you. Your career deserves protection—act now at https://www.doctorpodcastnetwork.co/setforlife_______________ In an era where misinformation can masquerade as science, how do you discern credible research? Host Dr. Bradley Block welcomes Dr. Katie Suleta, to unpack the importance of scrutinizing study authors and journals for conflicts of interest. Drawing from her recent experience with the Journal of Personalized Medicine, where a case study on supplements for autism treatment failed to disclose a lead author's affiliation with a supplement company, Dr. Suleta shares her journey to push for its retraction. This episode equips physicians with tools to inoculate themselves against junk science, emphasizing intellectual humility and lateral reading to protect patient care and public trust.Three Actionable Takeaways:Check Author Affiliations – Before reading a study, investigate authors' affiliations and potential conflicts of interest using readily available information to assess bias.Evaluate Journal Credibility – Be wary of journals with overly long or suspicious titles, and research their reputation to avoid predatory publications.Practice Lateral Reading – Cross-check studies or news articles with other sources to verify credibility and understand broader reactions, enhancing your information hygiene.About the Show:PGD  Physician's Guide to Doctoring covers patient interactions, burnout, career growth, personal finance, and more. If you're tired of dull medical lectures, tune in for real-world lessons we should have learned in med school!About the Guest:Dr. Katie Suleta is a trained epidemiologist with expertise in infectious diseases and health informatics, serving as the regional director of research and graduate medical education. She mentors residents daily and works as a science writer, contributing to outlets like the American Council on Science and Health, The Conversation, Skeptical Inquirer, and STAT News. Known for her advocacy against misinformation, Dr. Saleta recently exposed a case study in the Journal of Personalized Medicine where a lead author's undisclosed supplement company affiliation led her to push for its retraction, highlighting the need for transparency in scientific publishing.LinkedIn: http://linkedin.com/in/katherine-sota-ortecho-447a4899Instagram: https://www.instagram.com/katysota?igsh=Njd0NG4weW90OWJiAbout the Host Dr. Bradley Block is a board-certified otolaryngologist at ENT and Allergy Associates in Garden City, NY. He specializes in adult and pediatric ENT, with interests in sinusitis and obstructive sleep apnea. Dr. Block also hosts The Physician's Guide to Doctoring podcast, focusing on personal and professional development for physiciansWant to be a guest?Email Brad at brad@physiciansguidetodoctoring.com or visit www.physiciansguidetodoctoring.com to learn more!Socials:@physiciansguidetodoctoring on Facebook@physicianguidetodoctoring on YouTube@physiciansguide on Instagram and Twitter Visit www.physiciansguidetodoctoring.com to connect, dive deeper, and keep the conversation going. Let's grow! Disclaimer:This podcast is for informational purposes only and is not a substitute for professional medical, financial, or legal advice. Always consult a qualified professional for personalized guidance.

In this week's episode, we'll hear about how researchers look toward the lung, and find uniquely programmed blood stem cells. This study is the first to fully characterize hematopoietic stem and progenitor cells in the adult human lung. After that: researchers develop a neural network-based probabilistic classifier, DLBclass, that assigns all diffuse large B-cell lymphomas into one of five genetic subtypes. It's an inclusive taxonomy that they say provides actionable genetic information in almost all patients with DLBCL. Finally, new insights on NETS, or neutrophil extracellular traps. In the liver vasculature, NET removal leads to secondary inflammation, resulting in new waves of NETS that may impact future infection. We'll review these and other findings from this recent mouse model study.Featured Articles:Decoding functional hematopoietic progenitor cells in the adult human lungDLBclass: a probabilistic molecular classifier to guide clinical investigation and practice in diffuse large B-cell lymphomaDonor regulatory T-cell therapy to prevent graft-versus-host disease

Featuring articles on lipoprotein(a), familial polycythemia, leukocyte adhesion deficiency, COPD, and on policies on reducing alcohol consumption; a review article on addressing alcohol use; a Clinical Problem-Solving on gazing into a crystal ball; and Perspectives on death and taxes, on cancer metastases, and on a good innings.

Each year, hundreds of potentially world-changing treatments are discarded because scientists run out of cash. But where big pharma or altruists fear to tread, my friend and I have a solution. It's repugnant, but it will work By Alexander Masters. Read by Tom Andrews. Help support our independent journalism at theguardian.com/longreadpod

Lindsay Salguero-Lopez, 43, and Thomas Tartaglia, 64, share a love for kayaking, just one of the many activities both are now able to enjoy freely after receiving life-saving lung transplants. On this episode, they detail the realities of life before and after transplant, from the physical limitations and emotional toll of their conditions to the rigorous post-transplant care, lifestyle adjustments and ongoing medical management. Also joined by Aldo Iacono, MD, who oversees their care through the Northwell Transplant Institute, he explains the importance of finding the right program, longevity after transplant and the challenges of organ availability. Dr. Iacono is medical director of lung transplantation at the Northwell Transplant Institute. More about lung transplant at Northwell Watch Lindsay's lung transplant Listen to the sounds of surgery and how Northwell's lung transplant program began Read more about growing a transplant program About Northwell Health Northwell Health is New York State's largest healthcare provider and private employer, with 21 hospitals, 850 outpatient facilities and more than 16,600 affiliated physicians. We're making breakthroughs in medicine at the Feinstein Institutes for Medical Research. We're training the next generation of medical professionals at the visionary Donald and Barbara Zucker School of Medicine at Hofstra/Northwell and the Hofstra Northwell School of Nursing and Physician Assistant Studies. For information on our more than 100 medical specialties, visit Northwell.edu and follow us @NorthwellHealth on Facebook, Instagram, X and LinkedIn. Get the latest news and insights from our experts in the Northwell Newsroom: Press releases Insights Podcasts Publications Interested in a career at Northwell Health? Visit http://bit.ly/2Z7iHFL and explore our many opportunities. Get more expert insights from leading experts in the field — Northwell Newsroom.  Watch episodes of 20-Minute Health Talk on YouTube.  For information on our more than 100 medical specialties, visit Northwell.edu and follow us @NorthwellHealth on Facebook, Instagram, X and LinkedIn. Interested in a career at Northwell Health? Visit http://bit.ly/2Z7iHFL and explore our many opportunities.  

In this week's episode we'll learn more about how phosphoseryl-tRNA kinase inhibition promotes cell death in acute myeloid leukemia, or AML; APOE gene variants and their association with post-hematopoietic stem cell transplant outcomes in AML; and pathways by which chronic inflammation and oxidative stress may lead to cardiomyopathy in patients with sickle cell disease.Featured Articles:PSTK inhibition activates cGAS-STING, precipitating ferroptotic cell death in leukemic stem cells Common Hereditary Variants of the APOE Gene and Posttransplant Outcome in Acute Myeloid Leukemia 17R-Resolvin D1 Protects Against Sickle Cell Related Inflammatory Cardiomyopathy in Humanized Mice 

Featuring articles on bronchiectasis, influenza, clonal hematopoiesis of indeterminate potential, and metachromatic leukodystrophy; a review article on biology of the Fc neonatal receptor; a case report of a woman with sore throat and rash; and Perspectives on HIV preexposure prophylaxis, on fossil fuels, and on Medicaid's mandate for children and adolescents.

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In today's episode, "Federal Funding for Fish Conservation and Human Health," the crew discusses federal funding, its importance in the lives of fish and how we benefit as humans. We cover the US Fish & Wildlife Service, the US Department of Agriculture, the National Oceanic & Atmospheric Association, the National Institutes of Health, and the Environmental Protection Agency. Most of these agencies cost billions of dollars but they also save us billions in health costs, save countless lives and provide the nearly immeasurable intrinsic value that is resource and conservation services. When you add these all together, they comprise only 5% of the total US federal budget. We chat about the role of each agency, how it helps us and how you can get more information about them. At the end of the day, these agencies have open books because they are accountable to us and we think it's important to take them seriously.This podcast is brought to you by the bony eared assfish. Need we say more?For some more information, if you are interested:Check out the US Fish and Wildlife Service website to learn more about the important work they do to improve and preserve wild spaces and species.Check out the USDA National Institute of Food and Agriculture website to learn how they work to provide for healthy ecosystems as well as for the needs of Americans.Here's an article we referenced about who benefits from dismantling the Environmental Protection Agency.United for Medical Research shared a report on the profound impact that the National Institutes of Health (NIH) research funding has on the economy.If you want to see how your region is potentially affected by the federal funding cuts to science and research, you can check out SCIMaP.Thanks for listening to Gettin' Fishy With It! You can find our new website at www.gettinfishywithit.com. You can find us on Bluesky at @gettinfishypod.bsky.social and on Instagram⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ @gettingfishypod⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. You can also find us on ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Facebook⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ and⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠LinkedIn⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. If you want to drop us an email, you can send your complaints (or questions!) to gettingfishypod@gmail.com.Our theme music is “Best Time” by⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ FASSOUNDS⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Our audio is edited by Amber Park Chiodini. Amber has her own podcast all about movies, called⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ So What Happens Next?⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠We very much appreciate you taking the time to listen to our fifty-first episode! Please help out the podcast by subscribing on your podcast platform of choice. If you could leave us a review, that would be super helpful!If you would like to support the show, you can sign up as a paid member on our⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Substack⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, or you can ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠buy us a coffee⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠!Thanks and we'll “sea” you again in two weeks!

In this week's episode we'll learn about the role of autologous transplant for relapsed myeloma. In an updated analysis of the GMMG ReLApsE trial, salvage autologous transplant offered no survival benefit compared to control chemotherapy. These findings may have clinical implications in an era of alternative, and highly effective, treatment options. After that: Response to DDAVP, or desmopressin, in bleeding disorders. This study is the first large scale meta-analysis to assess the response rate to DDAVP in bleeding disorders. Authors provide new insights into determinants of response, which vary according to the disease type. Finally, turning to diffuse large B cell lymphoma. Germinal center B cells depend on the activity of DOT1 and EZH2 to maintain their pro-proliferative identity. New research shows that combined treatment with DOT1L and EZH2 inhibitors has synergistic activity in vitro.Featured Articles:Salvage autologous transplant in relapsed multiple myeloma: long-term follow-up of the phase 3 GMMG ReLApsE trialDDAVP response and its determinants in bleeding disorders: a systematic review and meta-analysisTargeting DOT1L and EZH2 synergizes in breaking the germinal center identity of diffuse large B-cell lymphoma

In this How I Treat series episode Blood Associate Editor, Dr. Jason Gotlib speaks with Drs. Aaron Gerds, Andreas Reiter, and Claire Harrison. The conversation focuses on the work and contributions of these authors to How I Treat Myeloproliferative Neoplasms, and exciting advances in the treatment and management of MPNs. See the full How I Treat series in volume 145 issue 16 of Blood.

Featuring articles on obinutuzumab in active lupus nephritis, tecovirimat for mpox, treatments for paroxysmal atrial fibrillation, and gene therapy for hemophilia B; a review article on enteral nutrition in hospitalized adults; a case report of a woman with cough and weight loss; and Perspectives on withdrawal of the United States from the WHO, on what's next for nicotine, on the value zeitgeist, and on doctors in revolution and war.

This is a special episode all about the Boston Marathon. The 129th Boston Marathon will take place on April 21, 2025 and holds a special place in the hearts of those in this episode. There are also 174 charities participating in the marathon. See below on how to show your support. Our guest in this episode is Dr. Kristin Whitney, who is an Assistant Professor in Orthopedics and Sports Medicine at Harvard Medical School and the Director of the Injured Runners Clinic at Boston Children's Hospital. She is also the Boston Marathon Medical Tracking Program Team Captain. We talk about Kristin's experiences and perspectives in these roles and how she has used her learnings and expertise to improve performance for others. She shares her story of a clinical care team that made a huge impact in her and her family's life and how that fueled her passion to bring excellent clinical care to so many today. Kristin also shares a groundbreaking study with a team that is on the frontiers of performance research. We were inspired by this conversation and hope it inspires you too! Thank you to our sponsors! The Wu Tsai Human Performance Alliance: https://humanperformancealliance.org/ Connect with Dr. Kristin Whitney! Website: https://www.childrenshospital.org/directory/kristin-whitney Instagram: @kristinwhitney.md Twitter: @KristinWhitney LinkedIn: https://www.linkedin.com/in/kristin-schwarz-whitney-md-ma-a1037947/ Boston Marathon Research Study: https://bjsm.bmj.com/content/59/4/222 Donate to Team Challenge ALS via Hannah's page: https://www.givengain.com/project/hannah-raising-funds-for-the-als-association-89275 Learn more about the ALS Association: https://www.als.org/ Donate to other 2025 Boston Marathon charities: https://www.baa.org/races/boston-marathon/charity-program Connect with BOOM! Twitter, Instagram, and Facebook: @biomechanicsonourminds LinkedIn: linkedin.com/company/biomechanicsoom/ YouTube: Biomechanics On Our Minds Website: biomechanicsonourminds.com More from Kristin and her team: Runners World Magazine feature: https://www.runnersworld.com/health-injuries/a63084616/low-energy-availability/ Boston Children's Hosp Blog: https://answers.childrenshospital.org/low-energy-availability-boston-marathon/

Send us a textOn a recent episode of a podcast, guest Amarillo Valle (pronounced Vi-yah) said, "We say, happiness is an inside job. Well, peace is an inside job, too!" His statement shook me. It woke me up from some deep slumber, a type of recurring dream where I kept putting others in charge of my experience, my joy, my happiness, my peace. Why did I give away my power? When did it happen? And how do I endeavor to take back the reins? I think Season Five of Curious Cat is that journey. Finding the bridge between what culture had said are two opposite forces, then harvesting the magic there.This week's exploration of the bridge is via music. A melody can move me to tears. Singing snaps me out of a funk. Humming makes my brain work better. Music is the way the dead reach out to me most often, maybe because it's the channel I'm open to receiving information on best.My first hint to the power of music was as a young mother. Once a week, I ventured out of the house to the local hospital and joined the moms class with my newborn. There were babies of many ages there, including some in the six to nine month range. I learned from the first class by observing, that age could get antsy, squirmy and the parent would stand up, hold the baby with two arms out front, and with the baby's back to them, the parent would rock forward and backward on their heels. That worked to calm the antsy babies. But if one baby began to cry, soon out of empathy, all the babies would join in. That's when we were instructed to sing, Twinkle, Twinkle, which the entire class did. And within seconds, all the babies quieted, eyes watching, calm. It was pure magic.Some of my most potent memories of my daughters as babies involved music, playing songs on a speaker or radio and dancing with them in my arms. I'm smiling ear to ear as I share this. Is there a song that makes you feel calm? Sad? Brings up a funny memory? Or annoys the heck out of you?Mine is Twelve Days of Christmas. If I'm preparing a meal for the family and that song comes on? Oh my gosh. It sends my anxiety through the roof. Music can help us fall asleep, a certain song can give us more energy than a cup of coffee,  enough to stay alert behind the wheel on a long drive, and impacts how we heal, recover, learn and rest. I've pulled the latest research from the internet and can't wait to share. Let's get into it.Show Sources & What to Watch/Listen/Read NEXTSound Heals, the movie, Thomas Durant (on Amazon for rental)The Healing Power of Sound as Meditation, Psychology TodayHave you tried the GoodPods app yet? It's free and a fun way to share podcasts with friends and family! Curious Cat Podcast is there, and is sitting pretty in the Top 5 of Angels and other categories! Be one of the first to share and recommend podcasts to your friends. Curious Cat Crew on Socials:Curious Cat on Twitter (X)Curious Cat on InstagramCurious Cat on TikTokArt Director, Nora, has a handmade, ethically-sourced jewelry company!

Part 1. On Executive Powers and the Courts Guest: Erwin Chemerinsky is the dean of the law school at the University of California, Berkeley. He is the author of many books on constitutional law including his latest, No Democracy Lasts Forever: How the Constitution Threatens the United States.  His latest opinion piece in The New York Times is We Should All Be Very, Very Afraid Part 2. Cuts to Medical Research  Guest: Chris Beyrer is Gary Hock Distinguished Professor in Global Health and Professor of Medicine at Duke University.  He is Associate Director of Global HIV at the Duke Center for AIDS Research (CFAR) and  Affiliate Faculty at Duke Human Vaccine Institute.  Dr Beyrer is a medical doctor and epidemiologist who has worked extensively on the front lines of HIV/AIDS and COVID-19 prevention, treatment, and research.   Photo by Sebastian Pichler on Unsplash The post Erwin Chemerinsky on Executive Powers and the Courts. Then, Cuts to Medical Research appeared first on KPFA.

Returning for a second study this month, the JHLT Digital Media Editors invite first author Charlotte Van Edom to discuss the paper, “Apixaban plasma levels in patients with HeartMate 3 support.” As a cardiologist in training and a PhD candidate at the University Hospitals Leuven in Belgium, Van Edom's work focuses on hemocompatibility and mechanical circulatory support, covering both short-term and long-term support. The episode explores: The evolution of the use and understanding of direct oral anticoagulants (DOACs) during LVAD support, including the increased focus on Factor Xa inhibitors Encouraging findings from the study and what clinical practices might need to change if introducing apixaban Additional studies exploring DOACs in LVAD patients For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt. Treat or research pulmonary vascular diseases? Check out the first April episode for a study on sotatercept in PAH patients. Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

In this week's episode we'll learn about the role of interleukin-1 signaling in the bone marrow microenvironment in the development of myelodysplastic syndromes, the immune checkpoint regulator VISTA as a potential target for preventing graft-vs-host disease, and epcoritamab plus gemcitabine and oxaliplatin in transplant-ineligible relapsed/refractory diffuse large B-cell lymphoma.Featured Articles:IL-1R1 and IL-18 signals regulate mesenchymal stromal cells in an aged murine model of myelodysplastic syndromesTargeting cell-surface VISTA expression on allospecific naïve T cells promotes toleranceEpcoritamab plus GemOx in transplant-ineligible relapsed/refractory DLBCL: results from the EPCORE NHL-2 trial

Featuring articles on cancer-associated venous thromboembolism, endovascular treatment for stroke, dapagliflozin in patients undergoing TAVI, screening for prostate cancer, and extrachromosomal DNA; a review article on otitis media in young children; a case report of a woman with flank pain, fever, and hypoxemia; and Perspectives on some efforts toward equity and on breaking the sacred promise.

We learn about Sickle Cell Disease and why it largely impacts African Americans. Tackling the lack of diversity in clinical research. We speak to the author of “Dear Black Girl: I See You.”

How many measles cases in 2025? Is there a blood test for Alzheimer's? Is the shingles vaccine safe? Does the shingles vaccine prevent dementia? AMA's Vice President of Science, Medicine and Public Health, Andrea Garcia, JD, MPH, covers measles outbreak news, a new blood test for Alzheimer's disease, the latest trends in childhood vaccination rates, and how the shingles vaccine helps prevent dementia. American Medical Association CXO Todd Unger hosts.

Join Dr. John Abramson and Robert Whitaker as they evaluate the trustworthiness of clinical trials and medical data. Understand the importance of reliable data in making informed health decisions. #ClinicalTrials #MedicalData #HealthEvidence

Featuring articles on HIV prevention, left atrial appendage closure after ablation for atrial fibrillation, timing of thrombolysis for stroke, congenital diarrhea and enteropathy, and the association between wealth and mortality in the United States and Europe; a review article on malaria; a Clinical Problem-Solving describing a “hot” cardiomyopathy; and Perspectives on physician shadowing, application overload, medical school grading, and impersonal personal statements.

Donate (no account necessary) | Subscribe (account required) Join Bryan Dean Wright, former CIA Operations Officer, as he breaks down today's top stories shaping America and the world in Friday's Headline Brief - heavy on news, light on analysis. Yemen Leak Fallout Continues – Political firestorm grows as Senator Wicker demands a classified briefing, while Judge Boasberg orders Trump officials to preserve Signal chat records. Critics aim to use the controversy to target key Trump cabinet members. B-2 Bombers Deployed as Middle East Tensions Escalate – U.S. stealth bombers arrive at Diego Garcia amid potential plans to strike Houthis - or Iran - if attacks on U.S. assets persist. Europe Backs Down on Ukraine Troop Promises – British and French pledges of soldiers fade, leaving only limited aid and 5B euros in military funding. Meanwhile, Trump pushes for economic control of Ukraine as part of a longer-term peace strategy. Massive Privacy Breach Hits U.S. Security Officials – German outlet Der Spiegel buys personal data of U.S. intelligence leaders, underscoring the broader debate over digital privacy and the DOGE program. Going Offline Could Improve Your Mental Health – Canadian researchers find that time away from phones reduces depression more than antidepressants - and boosts sleep, self-control, and social connection. Medical Breakthroughs on Gut Health – New studies link gut bacteria imbalances to multiple sclerosis and accelerated dementia. Probiotic use in children also shown to shorten fever duration. Get the facts, the analysis, and the truth-only on The Wright Report. "And you shall know the truth, and the truth shall make you free." - John 8:32

This week, after five years of research, two newly discovered antiviral molecules have been shown to combat coronaviruses. Johan Neyts of the Rega Institute for Medical Research in Leuven outlines how he hopes the new molecule developed by his team might help us deal with emerging pandemics in the future. But as the US halts all Covid related research, will drugs like these ever hit the shelves? Among the grants terminated this week by the National Institute for Health is a programme called AViDD, AntiViral Drug Discovery, supporting 9 independent consortia. Annette von Delft of Oxford University and Ed Griffen of the drugs discovery company MedChemica spoke to us about the overnight shut down of years of work and importance of antiviral development. The longest ever carbon-based molecules have been discovered by the Mars Curiosity rover. Caroline Freissinet of the Laboratoire Atmosphères et Observations Spatiales talked us through the meticulous planning and geological chance that made this possible, and whether these long chain alkanes could be a clue to discovering life on mars. Researchers at Vanderbilt University have been delving into the genetic evolution of horses to discover the mutation that's behind their runaway metabolic success. Gianni Castiglione explains how a mutation that should have been catastrophic instead helped horses to evolve from the size of dogs to the giant athletic animals we know today. Presenter: Roland Pease Producer: Emily Bird Production Coordinators: Jana Bennett-Holesworth and Josie Hardy(Photo: Two tablets of Roche Pharmaceuticals' Tamiflu. Photo by Nikos Pekiaridis/NurPhoto via Getty Images)

At 32, Todd Vande Hei was told his declining health was just “part of getting older,” and he believed it—until he didn't. Along with sharing how a shift in perspective led him to pursue measurable strategies to improve his well-being, he talks about ways you, too, can become the CEO of your own health. If you're tired of vague advice and want a smarter, test-based approach to longevity, this conversation will show you how to start.How long will you live? Take our quiz today to find out! Visit ageist.com/longevityquizThanks to Our SponsorsBON CHARGE: Want to try the hottest sauna blanket on the market? Check out BON CHARGE's Infrared Sauna Blanket, which is designed to provide easy access to the benefits of infrared heat therapy in the comfort of your own home, here.Troscriptions — Precision, pharmaceutical-grade nootropics for peak performance. Whether you need laser focus, mental clarity, or a boost in cognitive endurance, Troscriptions delivers science-backed results. Use code: AGEIST for 10% off, or click here.Fatty15 – C15 is the first essential fatty acid to be discovered In 90 years. Fatty15 is on a mission to replenish your C15 levels and restore your long-term health. Get 15% off their 90-day subscription Starter Kit here or enter code: AGEIST at checkout.Chapters(00:15) Introduction to Todd van de Heide and Stark Health(03:21) Todd's Health Journey: From Struggles to Transformation(06:14) The Importance of a Health Team(09:13) Questioning Medical Authority and Seeking Alternatives(12:14) The Role of Measurement in Health Optimization(15:04) The Evolution of Health Perspectives(18:28) Agency and Responsibility in Personal Health(21:21) The Future of Health and Medical Research(32:18) The Importance of Humility in Medicine(36:14) Defining Normal Health vs. Optimal Health(44:00) Shifting from Limitation to Possibility Mindset(49:51) Strategies for Health Across the Decades(55:42) Integrating Health, Work, and Life(59:38) Time Management for Well-BeingKey Moments“You have to be the CEO of your own health.”“Half of what doctors believe today will be proven wrong in 18 months—so you have to ask, what if they're wrong?”“Your health is more important than your money, yet most people track their finances far more carefully.”Connect With Todd Vande HeiStark HealthInstagram: @testodderone Connect With AGEISTNewsletterInstagramWebsiteCheck out the full interview transcriptSay hi to the AGEIST team!

Featuring articles on intensive blood-pressure control in patients with diabetes, IgG4-related disease, severe chronic rhinosinusitis, advanced breast cancer, and vaccinating against C. difficile infection; a review article on chronic cough in adults; a case report of a man with hepatocellular carcinoma; an editorial on order out of chaos; and Perspectives on health care bridges, on partnerships between pharmaceutical and telehealth companies, and on the definition of failure.

When details about a scientific study in the 1960s became public, there was shock, outrage and anxiety. But exactly what happened? By Samira Shackle. Read by Dinita Gohil. Help support our independent journalism at theguardian.com/longreadpod

EVEN MORE about this episode!What if you could unlock the healing power of spirit and step into a life of joy and purpose? In this episode, we connect with Sarah from Nottingham, searching for answers to her son Freddie's mysterious illness, and Daphne, exploring non-surgical solutions for knee pain. Deborah in Memphis seeks hope for her dog Perseus' lymphoma, while Sharon from Tucson navigates bone metastases. Through spiritual scans and energy healing, we uncover insights that transcend the physical.Chloe, a devoted listener, receives a heartwarming message from her late grandmother, reaffirming the eternal bonds of love. We also dive into heavy metal detoxification, cancer research, and the power of holistic healing.From personal health struggles to profound spiritual connections, this episode is a reminder that healing is always within reach. Tune in and discover how spirit and science unite to guide us toward wholeness.Episode Chapters:(0:00:01) - Spiritual and Practical Advice(0:11:11) - Healing Knees and Trusting Spirit(0:22:00) - Healing and Spiritual Communication(0:27:29) - Energy Healing and Medical Research(0:36:22) - Messages From Passed Loved Ones(0:48:31) - Healing Suggestions for Depletion and Cancer(0:56:12) - Brain Health and Medication ResearchSubscribe to Ask Julie Ryan YouTubeSubscribe to Ask Julie Ryan Español YouTubeSubscribe to Ask Julie Ryan Português YouTubeSubscribe to Ask Julie Ryan Deutsch YouTube✏️Ask Julie a Question!

The National Institutes of Health is a sprawling and complex institution that supports the work of hundreds of thousands of scientists at universities and labs across the country.Since Trump's inauguration that work has been stymied by confusion and uncertainty – potentially delaying or even preventing important medical research. The Post's science reporter Carolyn Johnson has been reporting on the turmoil at NIH and talks to Martine about how it could impact a generation of scientists. Today's show was produced by Emma Talkoff and Elana Gordon. It was edited by Maggie Penman and mixed by Sam Bair. Elana Gordon contributed reporting.Subscribe to The Washington Post here.

Changes limiting programs, grants, and even the nature of studies are already underway at the NIH, NSF, FDA, CDC, and more.On President Trump's first day in office, he signed an executive order to end what he calls “illegal and immoral discrimination programs,” referencing diversity, equity, and inclusion (DEI) in the federal government. The repercussions of this are already being felt across science agencies.Things are changing fast: Last week, a federal judge in Maryland temporarily blocked parts of the DEI purge from being carried out. At the same time, federal research agencies have already made changes. For example, the National Institutes of Health suddenly pulled a program that provides grants to PhD students from marginalized backgrounds, and has already canceled studies mid-project, like one on LGBTQ cancer patients. The National Science Foundation has begun reviewing active research science projects that may not comply with Trump's executive orders. The Centers for Disease Control and Prevention took down resources for HIV prevention, LGBTQ+ health, contraception, and more—then partially restored them, as ordered by a judge. And the Food and Drug Administration pulled its guidance on the importance of having some diversity in clinical trials, like those to test drugs and medical devices.So, what does banning diversity, equity, and inclusion efforts mean for medical research? And what does it mean for our health?Host Flora Lichtman talks with Dr. Rachel Hardeman, director of the Center for Antiracism Research for Health Equity at the University of Minnesota in Minneapolis; and Dr. Melissa Simon, an ob-gyn at Northwestern Medicine, and director of the Center for Health Equity Transformation in Chicago.Transcripts for each segment will be available after the show airs on sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.