Podcasts about Medical research

Sweet poison? New doubts cast over safety of erythritol; Is Greek yogurt a good way to enhance protein intake? Comparing whey, soy, and pea protein isolates; When taking supplements, is it advisable to take periodic breaks to enhance their effectiveness? Tommy John surgery pioneer and longtime Mets medical director dies at 68; Ivermectin, once branded useless “horse paste,” may prove a new weapon against malaria; New findings challenge notion that humans and apes share 99% of their DNA.

Henrietta Lacks was the first human being that we know of to get close enough to 'immortality' to touch it. She died more than 50 years ago but her cells live on.'HeLa' cells were the first human cells to be grown for research, and have been vital in medical advances since the 1950s.But what fascinated science major Rebecca Skloot the most about these cells, was how little was known about the woman behind the name.So she set out to discover who Henrietta Lacks really was.Further informationFirst broadcast in July, 2010.The Immortal Life of Henrietta Lacks is published by Picador.Rebecca's book was turned into a film starring Oprah Winfrey.You can learn more about Henrietta online.You can also hear Richard's full conversation with Helen Macdonald on the ABC Listen App or wherever you get your podcasts. You can also read all about the Conversations origin story on the ABC News website.This episode of Conversations explores science, science communication, weird science, female scientists, modern history, medicine, medical history, medical research, cells, cancer, curing disease.

Featuring articles on myeloma, mitochondrial DNA disease, cardiac surgery, and squamous-cell carcinoma; a review article on motor vehicle crash prevention; a case report of a woman with seizure-like activity and odd behaviors; a Medicine and Society article on the evaluation of occupational pulmonary impairment; and Perspectives on Covid-19 vaccines, on public policies, and on living on the edge of the valley of the sick.

In 2024, the Oxford English Dictionary announced its word of the year was ‘brain rot'. The term relates to the supposedly negative effects of consuming social media content, but it struck a chord more widely with many who feel they don't have the mental capacity they once had. Gloria Mark, a professor of informatics at the University of California, Irvine, has been studying our waning attention spans for 20 years. In this episode from January 2025, she tells Madeleine Finlay why she believes our powers of concentration are not beyond rescue, and reveals her top tips for finding focus. Help support our independent journalism at theguardian.com/sciencepod

Send us a textThe Kim B. Davis Show featuring Dr. Angela Celeste May, a clinical, organizational, and forensically trained psychologist, President and Co-founder of A.M. May and Associates, Inc., President and founder of Celeste Productions, Inc., Author, Editor, former columnist, Musician, and 2023 President's Distinction Award winner from the Michigan Psychological Association Foundation discusses, America's Obsession/Entitlement with Black Bodies. We talk about Adriana Smith, a brain dead woman who gave birth to a baby boy named Chance who is in NICU and we examine J. Marion Sims, the father of gynecology and the story of Henrietta Lacks whose cells were kept alive and used without her family's knowledge. The story continues on join in on the conversation.The Kim B. Davis Show is a conversational platform that engages issues around mental health, well-being, and political engagement. You can also email me at Kimberly@kimberlybatchelordavis.comSupport the showThank you for tuning in to the Kim B. Davis Show. You can visit KimBDavis.com to learn more about me as an author and you can find me on FaceBook, Instagram, Twitter, Snapchat, TikTok, and LinkedIn. You can see this show on YouTube.com/KimberlyBatchelorDavis. Thank you again for your support and always remember, Be Magnificent.

Scientists are beginning to understand that ageing is not a simply linear process. Instead, recent research appears to show that we age in three accelerated bursts; at about 40, 60 and 80 years old. To find out what might be going on, Ian Sample hears from Prof Michael Snyder, the director of the Center for Genomics and Personalised Medicine at Stanford University School of Medicine, who explains what the drivers of these bursts of ageing could be, and how they might be counteracted. Help support our independent journalism at theguardian.com/sciencepod

In this week's episode, we'll learn about a JAK inhibitor to prevent complications of CD19-directed CAR T-cell therapy. In a phase 2 study, itacitinib was well tolerated and demonstrated promising reductions in the incidence of cytokine release syndrome and neurotoxicity. After that: investigators report direct interactions between ChAdOx1 and platelets under arterial shear conditions. Investigators say it's a novel biophysical mechanism that potentially contributes to post-vaccination arterial thrombosis. Finally, we explore lineage switch, an emerging form of acute leukemia relapse with dismal outcomes. It arises rapidly following antigen-targeted immunotherapy, highlighting the importance of advanced methods for detection and treatment.Featured Articles: Itacitinib for the prevention of IEC therapy–associated CRS: results from the 2-part phase 2 INCB 39110-211 studyShear-dependent platelet aggregation by ChAdOx1 nCoV-19 vaccine: a novel biophysical mechanism for arterial thrombosisProject EVOLVE: an international analysis of postimmunotherapy lineage switch, an emergent form of relapse in leukemia

Featuring articles on type 2 diabetes, gastric cancer, lung cancer, and malaria; a review article on competency-based medical education; a case report of a man with cough, dyspnea, and hypoxemia; and Perspectives on brain death in pregnancy, on the Supreme Court's failure to protect trans minors, on real-world data, and on avocado and salt.

Matt Dun left school at 17 to join the Australian navy as a submariner and later finished his high school certificate as an adult attending TAFE at night.He then trained in biomedical science and was researching childhood leukaemia when his family received some devastating news, their little daughter Josie was diagnosed with terminal brain cancer.Matt turned all his energy and expertise into searching for treatments to help Josie and other children like her.He found running was one thing that helped him cope with the stress and pain of his daughter's illness, and with his wife founded the charity, RUN DIPGFurther informationThe charity founded by Matt and Phoebe Dun is RUN DIPGFind out more about the Conversations Live National Tour on the ABC website.This episode of Conversations was produced by Jen Leake, executive producer is Nicola Harrison.It explores childhood brain cancer, biomedical science, grief, family, DIPG, drug trials, research, submarines, the Australian Navy, running.

In this episode, Jessica Levinson unpacks the major legal clash between Harvard University and the Trump administration over a $2.6 billion freeze on federal research funding that impacts vital medical studies. Harvard argues the cuts violate its First Amendment rights and the Administrative Procedures Act, claiming they're being punished for not complying with federal demands related to antisemitism policies. The Trump administration insists it's merely a contract dispute, asserting their right to cut funding if Harvard doesn't align with federal priorities. Jessica highlights that the judge in the case seems skeptical of the Trump administration's stance and notes that the outcome could have sweeping effects on academic freedom and federal funding for universities across the country.Here are three key takeaways you don't want to miss:The Legal Battle Over Federal Funding and Academic Freedom: The episode centers on the case of Harvard University vs. the Trump administration over a $2.6 billion freeze in federal research funding to Harvard. Jessica Levinson explains that this legal clash is significant because it questions the extent of federal power over universities and touches on core issues of academic independence and freedom.Harvard's Arguments: First Amendment and Administrative Procedures Act: Harvard argues that the funding freeze violates its First Amendment rights—claiming it's being punished for not complying with federal demands that affect speech and institutional governance. Additionally, Harvard contends the Trump administration failed to follow the correct legal processes outlined in the Administrative Procedures Act, making the funding cuts arbitrary and lacking proper justification.The Trump Administration's Position and Judicial Skepticism: The Trump administration frames the dispute as a simple breach-of-contract issue, saying grant contracts allow for cancellation when an institution's actions don't align with federal priorities. In court, however, the judge sounded skeptical of the administration's position, questioning whether the funding cut was improperly suppressing speech and whether there was enough evidence to justify such a drastic move.Follow Our Host: @LevinsonJessica

Doctors in the UK have announced the birth of eight healthy babies after performing a groundbreaking procedure that creates IVF embryos with DNA from three people. Ian Sample tells Madeleine Finlay about the life-threatening genetic disorders that the technique appears to prevent, and Prof Sir Doug Turnbull describes the 25-year journey to achieving the breakthrough. Help support our independent journalism at theguardian.com/sciencepod

The University of Utah could lose more than $100 million in medical research grants. It poses an "existential threat" to the university's research mission. Holly and Greg discuss what this means for higher education in Utah, and one of the state's premier medical organizations. 

In this week's episode we'll learn more about the use of ruxolitinib plus dexamethasone to treat newly diagnosed patients with adult hemophagocytic lymphohistiocytosis; lysine-specific demethylase-1 inhibitors as a potential new class of therapies for sickle cell disease and other beta-globinopathies; and insights into clinical characteristics of patients with von Willebrand factor levels that are lower than normal but higher than those typically used to diagnose von Willebrand disease.Featured Articles:Ruxolitinib combined with dexamethasone for adult patients with newly diagnosed hemophagocytic lymphohistiocytosis in ChinaNovel, potent, and orally bioavailable LSD1 inhibitors induce fetal hemoglobin synthesis in a sickle cell disease mouse modelClinical phenotype and pathophysiological mechanisms underlying qualitative low VWF

The University of the Western Cape’s Comparative Spermatology Laboratory is looking for sperm donors for scientific research purposes and will even be compensating them for their contributions to science. Lester Kiewit speaks to Associate Professor Liana Maree about the purpose of this study. Good Morning Cape Town with Lester Kiewit is a podcast of the CapeTalk breakfast show. This programme is your authentic Cape Town wake-up call. Good Morning Cape Town with Lester Kiewit is informative, enlightening and accessible. The team’s ability to spot & share relevant and unusual stories make the programme inclusive and thought-provoking. Don’t miss the popular World View feature at 7:45am daily. Listen out for #LesterInYourLounge which is an outside broadcast – from the home of a listener in a different part of Cape Town - on the first Wednesday of every month. This show introduces you to interesting Capetonians as well as their favourite communities, habits, local personalities and neighbourhood news. Thank you for listening to a podcast from Good Morning Cape Town with Lester Kiewit. Listen live on Primedia+ weekdays between 06:00 and 09:00 (SA Time) to Good Morning CapeTalk with Lester Kiewit broadcast on CapeTalk https://buff.ly/NnFM3Nk For more from the show go to https://buff.ly/xGkqLbT or find all the catch-up podcasts here https://buff.ly/f9Eeb7i Subscribe to the CapeTalk Daily and Weekly Newsletters https://buff.ly/sbvVZD5 Follow us on social media CapeTalk on Facebook: https://www.facebook.com/CapeTalk CapeTalk on TikTok: https://www.tiktok.com/@capetalk CapeTalk on Instagram: https://www.instagram.com/ CapeTalk on X: https://x.com/CapeTalk CapeTalk on YouTube: https://www.youtube.com/@CapeTalk567 See omnystudio.com/listener for privacy information.

Madeleine Finlay is joined by Ian Sample to discuss three intriguing science and environment stories. From a breakthrough in the quest to create organs in the lab to a world-first climate visa that will see citizens relocate from the island of Tuvalu to Australia, plus what happens when two massive black holes collide. Help support our independent journalism at theguardian.com/sciencepod

In this episode, Associate Editor Dr. Philippe Armand discusses the Review Series on mantle cell lymphoma with author Dr. Christine Ryan. Both were authors of "Frontline management of mantle cell lymphoma", and discuss shifts in treatments and new research.Find the full review series in Volume 145 Issue 7 of Blood: "Review series on mantle cell lymphoma: sands shifting in the darkness"

Learning Objectives:Understand and analyze the key challenges facing healthcare systems in addressing the needs of an aging population with increasing rates of chronic and advanced illnesses.Describe the intersection of age-friendly care, geriatric and palliative care principles, and their synergistic application in improving the quality of life for individuals with multiple medical conditions.Identify strategies for implementing a more integrated and compassionate age friendly care approach that addresses the medical, functional, emotional, and social well-being of both patients and their family caregivers.Speaker:Maria Torroella Carney, MD, FACP, Professor, Institute of Health System Science, Feinstein Institutes for Medical Research; Chief, Geriatric and Palliative Medicine, Northwell Health; Associate Professor, Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellModerator:Gary Greensweig, DO, FAAFP, System SVP/Chief Physician Executive, Physician Enterprise; Interim Chief Medical & Quality Officer (CMQO)Panelists:Barbara Martin, PhD, ACNP-BC, MPH, System Senior VP of Advanced PracticePrentice Lipsey, President & CEO, Senior Living & Transitional Care, CommonSpirit Health

Prime Minister calls for more collaboration in Australia-China medical research, Three men accused of attempting to import more than $500 million worth of drugs, Wallabies coach Joe Schmidt says Nick Champion de Crespigny ready to make a big impression on his test debut.

Featuring articles on gastric and gastroesophageal junction cancer, pulmonary sarcoidosis, graft-versus-host disease, gastroenteritis in children, the rapid recovery of donor hearts after circulatory death, and an on-table reanimation of a pediatric heart from donation after circulatory death; a review article on fragile X disorders; a case report of a woman with neck swelling and dysphagia; and Perspectives on vaccine policy, on new mammography tools, and on the second life of Jacqui B.

Welcome back to Ditch the Lab Coat, the podcast where we break down the fascinating world of medicine with a blend of scientific skepticism and real-world insight. In today's episode, we dive deep into the mysteries of the vagus nerve—a nerve so ancient and essential, it's been called the “conductor” in the symphony of human physiology.Join host Dr. Mark Bonta as he sits down with Dr. Kevin Tracey, neurosurgeon, president and CEO of the Feinstein Institutes for Medical Research, and a pioneer in the world of bioelectronic medicine. Dr. Tracey's breakthrough research has shown us that the vagus nerve is far more than just a conduit for signals—it's a key player in managing inflammation, regulating our immune system, and maybe even shaping the future of medicine.In this conversation, you'll explore the mind-bending complexity of the nervous system, discover how cutting-edge science is redefining how we treat diseases like rheumatoid arthritis and long Covid, and learn how a tiny chip implanted in the neck might one day replace whole classes of immune-suppressing drugs. Dr. Tracey shares metaphors, straight talk about medical myths, and a vision for a future where reprogramming the body's reflexes could offer relief to millions.Get ready for a journey that's equal parts awe-inspiring and practical, as we unpack the true potential (and real-world considerations) of harnessing the vagus nerve's power. Whether you're a healthcare professional, a science nerd, or just someone searching for new answers, this episode invites you to see medicine in a whole new way. Resources : ( https://feinstein.northwell.edu/ )Episode HighlightsVagus Nerve Complexity Unveiled — We're only scratching the surface of understanding the vagus nerve's vast, intricate network and its essential bodily roles.Inflammation: Friend and Foe — Inflammation is vital short-term, but when uncontrolled, it's destructive and underlies many autoimmune and chronic diseases.Nervous-Immune System Interplay — The nervous and immune systems communicate reflexively, with nerves directly capable of controlling immune and inflammatory responses.Bioelectronic Treatments Emerge — Vagus nerve stimulation—via implanted chips—shows promise for conditions like rheumatoid arthritis without full-body immunosuppression risks.Individualized Nerve Fiber Functions — Each of the 200,000 vagus fibers controls specific functions, forming a body-wide symphony of precision responses.Not All Self-Help Fits — Lifestyle hacks can support vagus health, but serious disease often requires targeted nerve stimulation, not general wellness.Caution Against Online Misinformation — Vagus nerve advice online is often oversimplified or inaccurate; nuance and scientific backing are essential.Lifestyle Still Matters — Balanced diet, sleep, exercise, and community all help regulate vagus nerve tone and reduce chronic stress.Future Disease Applications Possible — Vagus stimulation may treat IBD, MS, and neurodegenerative or psychiatric conditions as research evolves.Episode Timestamps6:25 — Exploring Nervous System Complexity9:08 — Vagus Nerve Controls Inflammation11:05 — Vagus Nerve: Brain Signals Control Inflammation15:45 — Nervous System's Role in Immunity20:43 — Understanding Your Vagus Nerves23:25 — Vagus Nerve Health and Research25:12 — Vagus Nerve Stimulation Insights29:36 — Vagus Nerve Stimulator: Inflammation Therapy32:13 — Neurotransmitter Effects on Cytokine Production38:22 — Minimizing Nerve Damage in Surgery39:30 — Vagus Nerve Stimulation Benefits43:42 — Exploring Vagus Nerve Mysteries46:42 — Vagus Nerve Stimulation for Autoimmune Diseases50:52 — Cold Plunges & Bioelectrical Future DISCLAMER >>>>>>    The Ditch Lab Coat podcast serves solely for general informational purposes and does not serve as a substitute for professional medical services such as medicine or nursing. It does not establish a doctor/patient relationship, and the use of information from the podcast or linked materials is at the user's own risk. The content does not aim to replace professional medical advice, diagnosis, or treatment, and users should promptly seek guidance from healthcare professionals for any medical conditions.   >>>>>> The expressed opinions belong solely to the hosts and guests, and they do not necessarily reflect the views or opinions of the Hospitals, Clinics, Universities, or any other organization associated with the host or guests.    Disclosures: Ditch The Lab Coat podcast is produced by (Podkind.co) and is independent of Dr. Bonta's teaching and research roles at McMaster University, Temerty Faculty of Medicine and Queens University. 

In this week's episode, we'll learn about rapid, high-sensitivity diagnostic assays for TTP, or thrombotic thrombocytopenic purpura, that can reduce unnecessary treatments. After that: enhancing PD-1 blockade in relapsed/refractory extranodal NK/T-cell lymphoma. In a single-arm, phase 2 study, combined CD38 and PD-1 inhibition demonstrated durable responses and manageable safety. Finally, a lymphoma horror story with a happy ending. CREBBP mutations create a zombie enzyme that competes with its wild-type counterparts. By enforcing CD40 signaling, a bispecific antibody overcomes this effect and induces lymphoma cell death.Featured Articles:Rapid ADAMTS13 activity assays for thrombotic thrombocytopenic purpura: a systematic review and meta-analysisEfficacy of combined CD38 and PD-1 inhibition with isatuximab and cemiplimab for relapsed/refractory NK/T-cell lymphomaBlunted CD40-responsive enhancer activation in CREBBP-mutant lymphomas can be restored by enforced CD4 T-cell engagement

Featuring articles on mild asthma, cardiovascular risk factors, stroke, advanced breast cancer, and transforming health care; a review article on juvenile idiopathic arthritis; a case report of a man with headache and ataxia; and Perspectives on who will care for America, on hospital financial assistance policies, and on libraries burned, and a life lived.

In this week's episode we'll learn more about a novel mouse model that recapitulates many of the properties of human sickle cell SC disease; results from the induction phase of the risk-adapted MIDAS trial of isatuximab, carfilzomib, lenalidomide, and dexamethasone in newly diagnosed, transplant-eligible multiple myeloma; and a link between splicing factor mutations and competitive fitness in myelodysplastic syndrome stem cells.Featured articles:A novel mouse model of hemoglobin SC disease reveals mechanisms underlying beneficial effects of hydroxyureaIsatuximab, carfilzomib, lenalidomide, and dexamethasone induction in newly diagnosed myeloma: analysis of the MIDAS trialCell-autonomous dysregulation of interferon signaling drives clonal expansion of SRSF2-mutant MDS stem/progenitor cells

Victoria Jackson is a beauty industry pioneer whose billion-dollar brand helped define the “no-makeup makeup” movement — but her most powerful pivot came far beyond the world of cosmetics. In this episode, Victoria shares how building her business from her garage was just the beginning of a life shaped by resilience, reinvention, and purpose. When her daughter was diagnosed with a rare and life-threatening disease, Victoria left her company behind and stepped into the unknown, founding the Guthy-Jackson Charitable Foundation and ultimately funding groundbreaking medical research that led to the first FDA-approved treatments. Now at 70, she’s returning to beauty with a renewed mission and product line, reimagining beauty for women who, like her, are still evolving. Be sure to subscribe, leave us a rating, and share with your friends if you liked this episode! She Pivots was created by host Emily Tisch Sussman to highlight women, their stories, and how their pivot became their success. To learn more about Victoria, follow us on Instagram @ShePivotsThePodcast or visit shepivotsthepodcast.com. Support the show: https://www.shepivotsthepodcast.com/See omnystudio.com/listener for privacy information.

Featuring articles on structured exercise after chemotherapy for colon cancer, and treatments in obesity, in head and neck cancer, and in patients at high risk for cardiovascular events; a review article on forensic pathology; a Clinical Problem-Solving on caving in to pressure; a Sounding Board on climate change and human health; and Perspectives on the corporatization of U.S. health care, on self-neglect in older people, on Medicare drug price negotiation, and on the autopsy report.

On this episode of JHLT: The Podcast, the Digital Media Editors invite first author Joan Guzmán-Bofarull, and senior author, Marta Farrero, both of the Hospital Clinic de Barcelona in Spain. They join to discuss their paper, “Regional differences in primary graft dysfunction: A report from the international consortium on PGD.” The discussion explores: The international consortium on PGD, the composition of the study, and the practices of the included countries in the United States, Canada, and Europe Hypotheses on why the study shows better 30-day and 1-year outcomes in the United States Considerations transplant centers can take regarding recipient management and donor heart selection For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt. Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

With  the appointment of Robert F Kennedy, Jr.  as Secretary of Health and Human Services, the Trump administration has systematically targeted the next generation of scientists and public health leaders. He has cut science funding to its lowest level in decades. More than 20,000 jobs were eliminated, billions of dollars in scientific research has been threatened or paused, and a budget draft proposes a major restructuring of Health and Human Services.The Trump administration has asked Federal agencies to cancel contracts with Harvard worth an additional $450 million after canceling more than $2.2 billion in federal research grants. Among these grants and contracts were medical research projects.The proposed budget for the NIH includes a 40% cut, the CDC faces a budget cut of about half its spending, and the NSF (National Science Foundation) 2026 budget would be cut in half. These budget cuts could  drastically affect the health of Americans for generations.RFK, Jr , fired 17 expert members of a committee that advises the CDC on what vaccines people in the United States should take and when, making families less safe.And RFK, Jr. aims to prohibit government scientists from publishing in top journals, citing pharmaceutical influence and corruption concerns. He proposes new in-house journals for NIH-funded research, questioning the peer-review process of established journals.To help us understand the ramifications of all of this, we invited Stephen Spielberg, MD to help us through the complexities of this strange time in medicine and science.I asked Steve for some background information so I could introduce him properly on this podcast.  He replied “if you wake me in the middle of the night and ask what I “do”, I would say I am a doctor, a pediatrician, and all I have done as a basic and clinical scientist, as a medical school dean, as deputy commissioner of the FDA – all that comes back to a focus on the care of sick children, the prevention of disease, and optimization of health, and remembering humbly that we are all human, all on a vast journey of learning and striving for a better world.”I urge you all to read Steve's full biography at our web site (https://www.specificallyforseniors.com) about this podcast.Steve and I discussed medical research in the time of the Trump administration, the arbitrary cuts in funding of the NIH FDA and CDC, vaccines, RFK's proposal that research documentation be submitted to a government controlled journal, the status of medical research and the United States standing in the international order, public health and funding cuts and his personal experience treating two brothers with a rare genetic disorder.MEMORY LANE INFORMATIONFor Individuals, Family and Caregivershttps://bit.ly/4mtTG2hThere is a 30% discount for annual subscriptions, please use code SFORSENIORS in the promo box.For Professional Care Facilitieshttps://www.memory-lane.tv/contact-adult-carePlease place "Specifically for Seniors" in the Ambassador LineResearchhttps://www.memory-lane.tv/researchDisclaimer: Specifically for Seniors receives a small stipend with each subscription that helps to keep the podcast on the air. Please use the links for further information

It has been 25 years since Bill Clinton announced one of humanity's most important scientific achievements: the first draft of the human genome. At the time, there was a great deal of excitement about the benefits that this new knowledge would bring, with predictions about curing genetic diseases and even cancer. To find out which of them came to pass, and what could be in store over the next two-and-a-half decades, Madeleine Finlay is joined by science editor Ian Sample, and hears from Prof Matthew Hurles, director of the Wellcome Sanger Institute. Help support our independent journalism at theguardian.com/sciencepod

In this week's episode, we'll learn about using AI to assess transplant risk in myelofibrosis. In a step toward personalized medicine, researchers report on a machine learning model that identifies 25% of patients with poor outcomes. After that: preventing priapism in men with sickle cell anemia. A recent phase 2 feasibility study shows high rates of recruitment, retention, and adherence to oral therapies, coupled with a significant reduction in the risk of this difficult complication. Finally, new research indicates that hallmarks of terminal T-cell exhaustion are absent in multiple myeloma, from diagnosis through maintenance therapy. We explore these provocative and counterintuitive findings arising from profiling of blood and marrow samples.Featured Articles:Use of machine learning techniques to predict poor survival after hematopoietic cell transplantation for myelofibrosisA controlled trial for preventing priapism in sickle cell anemia: hydroxyurea plus placebo vs hydroxyurea plus tadalafilHallmarks of T-cell exhaustion and antigen experience are absent in multiple myeloma from diagnosis to maintenance therapy

Featuring articles on routine cerebral embolic protection for TAVI, and treatments for cirrhosis due to MASH, BRAF V600E metastatic colorectal cancer, and Pompe's disease; a new review article series on medical education; a case report of a woman with dyspnea on exertion; and Perspectives on addressing ultraprocessed foods, on the costs of dismantling DEI, and on a brother's keeper.

While tuberculosis is not a major health issue in New Zealand, worldwide it remains the leading infectious disease killer.   The vaccine against tuberculosis, called BCG, was first developed in France more than 100 years ago using a strain of bacteria that lost its disease-causing ability. Scientists refer to this as a live attenuated vaccine.   On Our Changing World, the Malaghan Institute's Dr Kerry Hilligan explains to Claire Concannon how this old vaccine is teaching researchers new tricks.

In this episode of the Bill Press Pod, Bill discusses the alarming cuts to medical and scientific research imposed by the Trump administration. Over 1,300 NIH research grants and over 150 clinical trials, including those on critical diseases like HIV, cancer, and chronic diseases, have been canceled or delayed. Colette Delawalla, founder of Stand Up for Science, talks about the detrimental impact of these cuts on the U.S.'s global leadership in science and the brain drain of scientists to other countries. Additionally, data reporter Irena Hwang from The New York Times provides insight into the extent and reasons behind these cuts, revealing that keywords linked to DEI initiatives were a significant factor in the grant cancellations. The episode highlights the far-reaching consequences for public health and scientific progress. Gift Link to the New York Times article: bit.ly/44pTQk6Today Bill highlights the work of Collette Delawalla's Stand up for Science organization. More information at StandupforScience.net.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Check out the TIES Sales Showdown at www.tx.ag/TIESVisit The Sales Lab at https://thesaleslab.org and check out all our guests' recommended readings at https://thesaleslab.org/reading-listTo listen to The Sales Lab Podcast on your favorite apps, visit https://thesaleslab.simplecast.com/ and select your preferred method of listening.Connect with us on Facebook at https://www.facebook.com/saleslabpodcastConnect with us on Linkedin at https://www.linkedin.com/company/thesaleslabSubscribe to The Sales Lab channel on YouTube at  https://www.youtube.com/channel/UCp703YWbD3-KO73NXUTBI-Q 

A Northwestern Medicine clinical trial led by Rod Passman, MD, could improve the way we care for millions of people with atrial fibrillation, but it is facing an unexpected challenge. There has been a pause in federal funding to Northwestern University that could impact this study's progress. While the trial has not been ordered to stop, all National Institutes of Health funding to Northwestern University has been frozen, raising questions about how long this potential life-saving work can go on without a resolution.  

In this week's episode, we'll learn more about social determinants of health that impact access to allogeneic hematopoietic cell transplantation in patients with acute myeloid leukemia, or AML; use of megakaryocyte growth factor receptor-based stem cell depletion as part of pretransplant conditioning in ex vivo autologous gene therapy; and identification of an eight-protein risk signature as well as a novel single protein biomarker, soluble oncostatin M receptor, for risk stratification in AML.Featured Articles:Social Determinants of Health and Access to Allogeneic Hematopoietic Cell Transplantation for Acute Myeloid LeukemiacMPL-Based Purification and Depletion of Human Hematopoietic Stem Cells: Implications for Pretransplant ConditioningBlood-Based Proteomic Profiling Identifies OSMR as a Novel Biomarker of AML Outcomes

In this final episode of our four-part series on Northwell's global health efforts in Jamaica, host Sandra Lindsay, RN, sits down with Eric Cioe-Peña, MD, vice president of Northwell's Center for Global Health. Dr. Cioe-Peña shares his personal journey into global health and how he honed Northwell's vast, but scattered efforts around the world into one centralized program that is building sustainable partnerships and making a difference that endures. They also discuss Northwell's unique approach to maximizing the impact of philanthropic giving, harnessing the power of countries with large populations in the U.S., like Guyana and Jamaica, and the future of global health. This is part four of our series. Listen to the entire series here.  About Northwell Health Northwell Health is New York State's largest healthcare provider and private employer, with 21 hospitals, 850 outpatient facilities and more than 16,600 affiliated physicians. We're making breakthroughs in medicine at the Feinstein Institutes for Medical Research. We're training the next generation of medical professionals at the visionary Donald and Barbara Zucker School of Medicine at Hofstra/Northwell and the Hofstra Northwell School of Nursing and Physician Assistant Studies. For information on our more than 100 medical specialties, visit Northwell.edu and follow us @NorthwellHealth on Facebook, Instagram, X and LinkedIn. Get the latest news and insights from our experts in the Northwell Newsroom: Press releases Insights Podcasts Publications Interested in a career at Northwell Health? Visit http://bit.ly/2Z7iHFL and explore our many opportunities. Get more expert insights from leading experts in the field — Northwell Newsroom.  Watch episodes of 20-Minute Health Talk on YouTube.  For information on our more than 100 medical specialties, visit Northwell.edu and follow us @NorthwellHealth on Facebook, Instagram, X and LinkedIn. Interested in a career at Northwell Health? Visit http://bit.ly/2Z7iHFL and explore our many opportunities.  

Blood editor Dr. Laurie Sehn discusses the topic of "Aggressive non-Hodgkin lymphoma: defining and managing high-risk subsets" featuring Drs. Mark Roschewski, Grzegorz Nowakowski, and Neha Mehta-Shah, who each contributed to the articles featured in the review series on high-risk aggressive lymphoma.See the full review series on high risk lymphoma in volume 144, issue 25 of Blood.

Featuring articles on mismatch repair–deficient tumors, generalized myasthenia gravis, HER2-mutant non–small-cell lung cancer, a Corynebacterium diphtheriae outbreak, and hereditary and sporadic papillary kidney cancer; a review article on unruptured intracranial aneurysms; a case report of a man with respiratory failure and shock after kidney transplantation; and Perspectives on medical AI and clinician surveillance, on pathobiology, and on unrest.

Professor Lorimer Moseley is neuroscientist, who specialises in the complexities and mind-boggling nature of pain - what it is, why it exists, how it works and when it can go wrong.For most of us, pain is a fundamental part of being alive, and staying alive and yet none of us will ever experience the exact same pain as someone else, which makes it incredibly difficult to understand.Every day, we stub our toes and burn our tongues. Some of us break bones and suffer from more serious illnesses and conditions.What you feel when your skin is broken or a ligament is torn is there to tell your brain to be careful, that something is wrong and needs to be protected.But what happens when doctors can't find any damage? When the tissues in your hips or the pictures of your brain seem perfectly fine, but still, there is agonising pain that refuses to leave you alone?Lorimer was a physiotherapist who came to this very specific neuroscience after his own experience with chronic pain, following a pretty gruesome sporting injury that by all accounts had been fixed by surgery.He realised that as he was learning more about how changes in the body are detected (like temperature and pressure), and communicated as pain to the brain through the central nervous system, his own chronic pain started to diminish.Since then, Lorimer has published hundreds of papers and several books on the topic, in his pursuit to help people also dig themselves out of the hellish cruelty of chronic pain.Further informationYou can find more resources from Professor Moseley about tackling persistent or chronic pain online at TameTheBeast.orgFind out more about the Conversations Live National Tour on the ABC website.The Executive Producer of Conversations in Nicola Harrison. This episode was produced by Meggie Morris and presented by Richard Fidler. It explores persistent pain, migraine, arthritis, neurology, psychology, distrust of the medical system, pain relief, hypersensitivity to pain, doctors who believe you, chronic conditions, endometriosis.

In this weekend's episode, three segments from this past week's Washington Journal. First, with a federalized national guard and the Marines on the streets of Los Angeles – a conversation with Mary McCord of Georgetown Law about the legal and Constitutional issues surrounding the domestic deployment of the U.S. military. Then, Former NIH Director Dr. Harold Varmus (VARR-muss) discusses how spending cuts to his former agency is impacting the future of federal medical research. And finally we chat with Wall Street Journal trade reporter Gavin Bade on the latest in U.S.-China trade talks Learn more about your ad choices. Visit megaphone.fm/adchoices

Technologists Bill Gates and Sébastien Bubeck discuss the state of generative AI in medicine, how access to “medical intelligence” might help empower people across healthcare, and how AI's accelerating improvements are likely to affect both delivery and discovery.

In part three of our four-part series, From New York to Jamaica: A Healthcare Partnership, host Sandra Lindsay, RN, reunites with the Northwell Health OB/GYN team who traveled to Kingston in September 2024 to provide pro bono fibroid surgeries. Drs. Michael Nimaroff, Monique Jones, Ruqayyah Abdul-Karim, and Dillon Gurciullo share personal reflections on their experiences collaborating with Jamaican healthcare professionals, navigating the challenges of limited resources, the joys of cultural exchange, and the profound impact of providing life-changing care for women who had been waiting years for surgery. Hear how this unique collaboration is strengthening the Jamaican healthcare system and fostering a spirit of partnership and shared learning between Northwell Health and the University Hospital of the West Indies. This episode offers an inside look at the dedication and passion driving this initiative and its potential to create a healthier future for women in Jamaica. This is part three of our series. You can listen to other episodes here.  About Northwell Health Northwell Health is New York State's largest healthcare provider and private employer, with 21 hospitals, 850 outpatient facilities and more than 16,600 affiliated physicians. We're making breakthroughs in medicine at the Feinstein Institutes for Medical Research. We're training the next generation of medical professionals at the visionary Donald and Barbara Zucker School of Medicine at Hofstra/Northwell and the Hofstra Northwell School of Nursing and Physician Assistant Studies. For information on our more than 100 medical specialties, visit Northwell.edu and follow us @NorthwellHealth on Facebook, Instagram, X and LinkedIn. Get the latest news and insights from our experts in the Northwell Newsroom: Press releases Insights Podcasts Publications Interested in a career at Northwell Health? Visit http://bit.ly/2Z7iHFL and explore our many opportunities. Get more expert insights from leading experts in the field — Northwell Newsroom.  Watch episodes of 20-Minute Health Talk on YouTube.  For information on our more than 100 medical specialties, visit Northwell.edu and follow us @NorthwellHealth on Facebook, Instagram, X and LinkedIn. Interested in a career at Northwell Health? Visit http://bit.ly/2Z7iHFL and explore our many opportunities.  

In this week's episode, we' ll learn about how TET3 has a key role in GVHD. In mice, a deficiency of Tet3 in donor T cells inhibited pathogenic immunoglobulin class switching and suppressed lung fibrosis. Accordingly, TET3 may be a new therapeutic target in chronic GVHD. After that: rilzabrutinib, a BTK inhibitor for ITP. In a randomized, placebo-controlled trial, treatment produced rapid and durable platelet responses, with acceptable safety, in adults with immune thrombocytopenia who had failed multiple previous therapies. Finally: exploring pre-TCR surface expression patterns in T-cell ALL. Co-inhibition of the interleukin-7 receptor and pre-T cell receptor pathways may play a therapeutic role for a subset of T-lymphoblastic leukemias.Featured Articles: Deficiency of T follicular helper cell Tet3 DNA demethylation inhibits pathogenic IgG2c class switching and chronic GVHDSafety and efficacy of rilzabrutinib vs placebo in adults with immune thrombocytopenia: the phase 3 LUNA3 studySurface pTα expression predicts LCK activation and preclinical synergy of LCK and JAK coinhibition in adult T-ALL

Featuring articles on treatments for pulmonary fibrosis, for obesity and overweight, for severe hemophilia B, and for a rare genetic disease; a review article on malnutrition in older adults; a case report of a man with a nasopharyngeal mass; a Medicine and Society on John Collins Warren; and Perspectives on undermining women's health research, on addressing antifungal drug resistance, and on conversations that matter in maternal medicine.

Dr Jayashri Kulkarni on her Indian-Australian upbringing and her groundbreaking research into women's hormones and mental health (R)Jayashri Kulkarni's family moved from India to Australia in 1961.They found there were no Indian grocery stores, few spices of any kind, and plain yoghurt wasn't available.But the Kulkarnis adapted to their new home, teaching their neighbours how to cook Indian food, and encouraging Jayashri's love for studying.Jayashri became a doctor, and during her training as a psychiatrist she became fascinated by the relationship between women's hormones and mental health.She's since been at the frontline of groundbreaking research, which challenged many of her colleagues and ended up helping women all over the world.Further informationFirst broadcast in February 2024.Find out more about the Conversations Live National Tour on the ABC website.Conversations' Executive Producer is Nicola Harrison. This episode was produced by Tamar Cranswick and presented by Sarah Kanowski.It explores female health, medical research, menopause, perimenopause, hormonal health, female medical research, migration, studying medicine, depression, anxiety, gut health, why don't doctors listen to women, gender stereotypes, underrepresentation in medical research, gaslighting in women's health, women's pain, motherhood, stress, psychiatry, reproductive health, hormonal birth control.

Featuring articles on metabolic dysfunction–associated steatohepatitis, lung nodules, breast cancer, and improving birth outcomes; a review article on hemoglobinopathies; a Clinical Problem-Solving on from where it stems; and Perspectives on U.S. research leadership at a crossroads, on health care in an evolving immigration landscape, and on carrying hope while facing a crisis.

Amar Kelkar is a physician at the Dana-Farber Cancer Institute and an instructor in medicine at Harvard Medical School. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. A.H. Kelkar. U.S. Research Leadership at a Crossroads — The Impact of Reducing NIH Indirect-Cost Coverage. N Engl J Med 2025;392:2081-2084.

Featuring articles on pulmonary arterial hypertension, oral semaglutide and cardiovascular outcomes, giant-cell arteritis, the loss of subsidized drug coverage and mortality, and neutralizing venom toxins; a review article on cancer of unknown primary site; a case report of a man with fever, nausea, and respiratory failure; and Perspectives on primary care and the free market, federal cuts at the VA, the GINA gap, and the meaning of goodbye.

Some call it your sixth sense. You refer to it when you have a “gut feeling.” With a vast fiber network running throughout your body, the vagus nerve knows about and helps regulate every critical function in it, from heart rate to digestion to your immune system. Now bioelectric medicine is tapping into that bodily omniscience by using tiny electrical pulses on the vagus nerve to help treat diseases as diverse as epilepsy, diabetes, stroke, Parkinson's, and even depression. In the coming months, the FDA is set to make a decision about a vagus nerve stimulation device, which, if approved, could provide first-of-its-kind treatment for an autoimmune disease that affects millions of Americans. We consider the groundbreaking potential of vagus nerve stimulation and ask whether electricity could one day replace medications. Guest: Kevin Tracey – Neurosurgeon, president of the Feinstein Institutes for Medical Research at Northwell Health, and author of “The Great Nerve: The New Science of the Vagus Nerve and How to Harness Its Healing Reflexes”  Featuring music by Dewey Dellay and Jun Miyake You can get early access to ad-free versions of every episode by joining us on Patreon. Thanks for your support! Big Picture Science is part of the Airwave Media podcast network. Please contact advertising@airwavemedia.com to inquire about advertising on Big Picture Science. Learn more about your ad choices. Visit megaphone.fm/adchoices

In medicine, failure can be catastrophic. It can also produce discoveries that save millions of lives. Tales from the front line, the lab, and the I.T. department. SOURCES:Amy Edmondson, professor of leadership management at Harvard Business School.Carole Hemmelgarn, co-founder of Patients for Patient Safety U.S. and director of the Clinical Quality, Safety & Leadership Master's program at Georgetown University.Gary Klein, cognitive psychologist and pioneer in the field of naturalistic decision making.Robert Langer, institute professor and head of the Langer Lab at the Massachusetts Institute of Technology.John Van Reenen, professor at the London School of Economics. RESOURCES:Right Kind of Wrong: The Science of Failing Well, by Amy Edmondson (2023).“Reconsidering the Application of Systems Thinking in Healthcare: The RaDonda Vaught Case,” by Connor Lusk, Elise DeForest, Gabriel Segarra, David M. Neyens, James H. Abernathy III, and Ken Catchpole (British Journal of Anaesthesia, 2022)."Estimates of preventable hospital deaths are too high, new study shows," by Bill Hathaway (Yale News, 2020).“Dispelling the Myth That Organizations Learn From Failure,” by Jeffrey Ray (SSRN, 2016).“A New, Evidence-Based Estimate of Patient Harms Associated With Hospital Care,” by John T. James (Journal of Patient Safety, 2013).To Err is Human: Building a Safer Health System, by the National Academy of Sciences (1999).“Polymers for the Sustained Release of Proteins and Other Macromolecules,” by Robert Langer and Judah Folkman (Nature, 1976).The Innovation and Diffusion Podcast, by John Van Reenen and Ruveyda Gozen. EXTRAS:"The Curious, Brilliant, Vanishing Mr. Feynman," series by Freakonomics Radio (2024).“Will a Covid-19 Vaccine Change the Future of Medical Research?” by Freakonomics Radio (2020).“Bad Medicine, Part 3: Death by Diagnosis,” by Freakonomics Radio (2016).