Podcasts about Medical research

Bioelectronic medicine is changing how we treat inflammation, autoimmunity, and chronic disease, and this episode shows you exactly how nerve stimulation could redefine human performance, longevity, and brain optimization. You will learn how electricity, neurotransmitters, and targeted neural pathways can replace drugs, control inflammation, and help you hack the vagus nerve with precision instead of guesswork. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey is joined by Kevin J. Tracey, MD, president and CEO of the Feinstein Institutes for Medical Research at Northwell Health, pioneer of vagus nerve research, and author of The Great Nerve. He is one of the world's most cited scientists in inflammation and neuroscience, and his discoveries created the field now known as bioelectronic medicine. He identified the therapeutic action of anti TNF antibodies, mapped the inflammatory reflex, and revealed how vagus nerve signaling controls immunity. With more than 450 scientific publications and over 120 U.S. patents, he is a trusted authority whose work drives the future of anti-aging, functional medicine, metabolism, and neural therapies. Dr. Tracey and Host Dave Asprey explore how the vagus nerve truly operates, why it contains 200,000 fibers with different functions, and what happens when you stimulate specific pathways that regulate inflammation, HRV, neurotransmitters, and immune signaling. You will learn how nerve impulses transmit information, how voltage gated ion channels shape behavior and biology, and why certain forms of stimulation create measurable improvements in mitochondria, metabolic control, sleep optimization, and emotional regulation. They break down the science behind surgical vagus nerve implants, focused ultrasound, gamma entrainment, cytokine control, and real neuromodulation. They also explore why cold plunging, breath work, HRV training, nootropics, and consumer devices vary so widely in their effects, and how to evaluate these tools with practical biohacking frameworks. You will hear what actually works, what remains experimental, and what the next decade of nerve based therapies could unlock for brain optimization, longevity, ketosis, fasting, supplements, and AI guided interventions in human biology. You'll Learn: • How vagus nerve stimulation reduces inflammation through the inflammatory reflex • Why bioelectronic medicine can replace drugs in autoimmune conditions • How nerve fibers relay electrical and chemical signals inside the body • Why cold immersion, breath work, and HRV training activate specific vagal pathways • How 40 hertz gamma entrainment may influence cognitive decline • Which stimulation methods have clinical validation and which do not • Why high vagal tone is linked to better metabolism, immunity, and emotional stability • What future nerve based technologies may unlock for human performance Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Kevin J. Tracey, vagus nerve stimulation, bioelectronic medicine, inflammatory reflex, SetPoint Medical, cytokine control, neuromodulation therapy, autonomic nervous system, HRV optimization, inflammation reduction, rheumatoid arthritis treatment, focused ultrasound therapy, gamma entrainment, mitochondrial signaling, anti-aging science, neural pathway hacking, functional medicine research, immune system regulation, brain and body performance, human longevity science Thank you to our sponsors! -AquaTru | Go to https://aquatruwater.com/daveasprey and save $100 on all AquaTru water purifiers. -MASA Chips | Go to https://www.masachips.com/DAVEASPREY and use code DAVEASPREY for 25% off your first order. -Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. -Calroy | Head to https://calroy.com/dave for an exclusive discount Resources: • Learn More About Kevin's Work: https://feinstein.northwell.edu/institutes-researchers/our-researchers/kevin-j-tracey-md • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 - Trailer 1:12 - Bioelectronic Medicine 3:23 - FDA Approval 6:48 - RA Treatment Explained 11:35 - Vagus Nerve Function 15:12 - External vs Implanted Stimulation 18:06 - Focused Ultrasound 26:11 - Ear Stimulation Science 30:51 - Clinical Evidence 37:10 - Alzheimer's Link 42:15 - Future Applications 46:48 - Cold Exposure Effects 53:51 - Common Misconceptions 55:38 - Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

BUFFALO, NY – November 17, 2025 – A new #research perspective was #published in Oncotarget (Volume 16) on November 14, 2025, titled “A personal perspective of patient-centred clinical trials.” In this perspective, led by corresponding author Jia Liu of The Kinghorn Cancer Centre, St Vincent's Hospital, the University of New South Wales, and the Garvan Institute of Medical Research, three early-phase clinical trial participants — Trevor Tyne, Elizabeth Ivimey, and Leanne Duggan — reflect on their personal experiences with experimental cancer treatments. Their stories offer a unique perspective on the patient journey through early-phase trials and emphasize the need to design clinical research that prioritizes patients' needs, dignity, and lived realities. The authors highlight both the life-changing opportunities that trials can provide and the systemic barriers that still prevent many patients from participating. This perspective captures a turning point in how early-phase trials are viewed. Once considered a last resort, these trials are now increasingly offered earlier in treatment, especially with the rise of biomarker-guided therapies. In this context, the patient experience has become critical. The authors outline key benefits of participation, including access to novel therapies, ongoing medical monitoring, emotional support, and a strong sense of purpose in contributing to future medical advancements. However, they also point out significant challenges, such as restrictive eligibility criteria, high financial and logistical burdens, and communication gaps between patients and trial staff. “While no trial guarantees success, the level of support, access to innovative therapies, and sense of contribution to medical progress can be profoundly meaningful.” Each narrative provides insight into the clinical trial experience. One patient explains how living with a visual impairment required tailored accessibility support throughout the trial process Another shares how genomic testing led to targeted treatment after standard options failed. Despite their different diagnoses and circumstances, all three stories reflect resilience, hope, and a shared call for trial designs that better reflect the realities of diverse patients. To address these issues, the authors propose a number of improvements to trial design and delivery. These include expanding eligibility criteria, offering financial and logistical assistance, improving communication training for research staff, and introducing dedicated trial navigators to help guide patients through complex processes. They also focus on the importance of involving patient advocates in trial design and ensuring smoother transitions for patients moving between treatment centers. While early-phase trials focus on safety and effectiveness, the authors argue they must also be guided by core values like ethics and patient empowerment. This perspective serves as a reminder that the future of cancer research depends not only on scientific innovation, but on an honest partnership between patients and the research community. By sharing these real-world experiences, the article encourages a broader conversation about how to make clinical trials more responsive to the people they are designed to serve. DOI - https://doi.org/10.18632/oncotarget.28776 Correspondence to - Jia Liu - jia.liu@svha.org.au Abstract video - https://www.youtube.com/watch?v=2CCGN78n8ug To learn more about Oncotarget, visit https://www.oncotarget.com: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

Ian Sample joins Madeleine Finlay to discuss some of the most intriguing science stories from the week. They discuss the complicated legacy of James Watson, who won the Nobel Prize for the discovery of the structure of DNA; a new breakthrough in the quest to understand the autoimmune disease lupus; and why everyone from Joe Rogan to Kim Kardashian is talking about comet 3I/Atlas.. Help support our independent journalism at theguardian.com/sciencepod

In this week's episode, associate editor Dr. James Griffin interviews researchers Dr. John Semple and Dr. Othman Al-Sawaf on their groundbreaking studies on transfusion-related acute lung injury and chronic lymphocytic leukemia treatment. Dr. Semple explored how mitochondrial DNA could act as a first hit in lung injury, while Dr. Al-Sawaf revealed that patient fitness may not significantly impact the efficacy of targeted CLL treatments. Both studies challenge existing medical assumptions and suggest new approaches to understanding disease mechanisms and treatment responses.Featured ArticlesThe impact of fitness and dose intensity on clinical outcomes with venetoclax-obinutuzumab in CLLMitochondrial DNA via recipient TLR9 acts as a potent first-hit in murine transfusion-related acute lung injury (TRALI)

Send us a textThis episode features Dr. Sofia Isabel Perazzo (Children's National Hospital) and Dr. Rakesh Rao (St. Louis Children's Hospital) discussing a CHNC Explore analysis of intestinal stricture formation following surgical necrotizing enterocolitis (NEC). Using 15 years of CHND data, they examined over 2,400 surgical NEC cases, finding an overall stricture incidence of about 31%, with striking inter-center variability (24–38%). Lower gestational age, stoma creation, and combined drainage-laparotomy increased risk, while peritoneal drainage was protective. Hispanic ethnicity was associated with lower risk. Although their predictive model (AUC 0.67) was modest, the findings offer valuable benchmarks for parent counseling, quality improvement, and hypothesis generation.Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

In this episode, we look at new trials on deferring arterial catheterization in shock, beta-blocker use after myocardial infarction, and a treatment for triple-negative breast cancer. We review acromegaly. A case describes a man with dyspnea, edema, and pacemaker lead displacement. We explore perspectives on the burdens of primary care, the erosion of harm reduction, child health policy, and the meaning of hospice.

Send us a textWe trace how sex and gender shape drug development, from male-heavy mouse studies to the split results in Lecanemab's Alzheimer's trial. Experts explain why regulators should keep approvals moving while demanding smarter design, better reporting, and post-approval answers. For more science stories, visit our website swisinfo.ch, and you can help other people to find our podcast by leaving us a five-star review.Journalist: Jessica Davis PlüssHost: Jo FahyAudio editor/video journalist: Michele AndinaDistribution and Marketing: Xin ZhangSWI swissinfo.ch is a public service media company based in Bern, Switzerland.

Davina opened up to us about her recent breast cancer diagnosis and treatment. She talks about how it made her feel and what you should be doing, check your boobs!We all love Davina McCall and we love her coming to Southampton each year for the event 'Dine with Davina' in support of Action Medical Research, she always sparkles.Sending so so many big, but gentle hugs to you Davina.

In this episode, hosts Jason and Joelle chat with Adam Nebbs, Postdoctoral Research Fellow at the Menzies Institute for Medical Research. Adam discusses the recently published research that formed part of his PhD, working with six organisations in a regional part of Australia as they translated ISO 45003 recommendations into tangible actions for implementation.

Investigadores del Stowers Institute for Medical Research han descubierto que en seres vivos como el gusano plano de tres lineas que tiene la capacidad de regenerarse cuando lo cortan, lo que activa esa regeneracion es el estres que sufre la herida misma. Por tanto, cuando el animal que tiene esta capacidad sufre una lesion, inmediatamente activa una senal biologica que hace que las celulas regeneren la parte perdida.

with Charles Malki of IV OrganicsIn This Episode: Greg interviews Charles Malki, a multifaceted biologist, attorney, author, and inventor, about the innovative benefits of whitewashing trees. Charles details his journey from a passion for plant sciences during his childhood to a career in medicine and law, ultimately leading to the creation of Ivy Organic. He explains the importance of whitewashing for tree protection against weather extremes and pests, emphasizing the environmental benefits of using organic products. The discussion also covers the genesis of Ivy Organics, the science behind their product formulations, and their impact on both small-scale gardeners and commercial orchards. Charles shares valuable personal and professional anecdotes, highlighting the significance of setting clear goals, fostering beneficial relationships, and continually educating oneself and others about sustainable gardening practices.Our Guest:  Charles Malki is a biologist, attorney, all American swimmer, philanthropist, inventor, entrepreneur, and author. He has been published in journals, including the Journal of Surgical Research and American Federation of Medical Research. At the heart of all of his successes is his love of life and his passion to educate others on the limitless topics that rotate to plant sciences, and it all benefits you, your family and friends, community, and our planet.Connect with IV Organics - IVOrganics.comBook recommendations -  Saving the World with the Home Garden by Charles MalkiThe Secret by Rhonda ByrneVisit UrbanFarm.org/IVOrganics for the show notes and links on this episode! Need a little bit of advice or just a feedback on your design for your yard or garden?The Urban Farm Team is offering consults over the phone or zoom. Get the benefits of a personalized garden and yard space analysis without the cost of trip charges. You can chat with Greg, Janis or Ray to get permaculture based feedback.Click HERE to learn more!Become an Urban Farm Patron and listen to more than 900 episodes of the Urban Farm Podcast without ads. Click HERE to learn more.*Disclosure: Some of the links in our podcast show notes and blog posts are affiliate links and if you go through them to make a purchase, we will earn a nominal commission at no cost to you. We offer links to items recommended by our podcast guests and guest writers as a service to our audience and these items are not selected because of the commission we receive from your purchases. We know the decision is yours, and whether you decide to buy something is completely up to you.

In this week's episode, Blood editor Dr. Laura Michaelis interviews author Dr. Taylor Brooks on his latest paper published in volume 146 issue 18 of Blood Journal. The conversation discusses outcomes of bispecific antibodies (epcoritamab or glofitamab) in treating aggressive B-cell lymphoma in a study with 245 patients. Findings show a tentative way forward in treatment for patients with relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL).Featured Article:Real-world outcomes of patients with aggressive B-cell lymphoma treated with epcoritamab or glofitamab

In this episode, we discuss long-term outcomes after chest-wall irradiation for breast cancer, new treatments for psoriasis and obesity, and early results on a vaccine for Lassa fever. We review opioid deprescribing and a clinical case describes spiraling into a distant past. Perspectives examine the corporatization of health care, the health effects of new energy legislation, and Medicaid cuts affecting U.S. children.

In this episode of the Ardan Labs Podcast, Bill Kennedy talks with Salah Mahmud, a medical researcher specializing in epidemiology and medical statistics. Salah shares his journey from growing up in Libya under Gaddafi's regime to conducting cutting-edge research in Canada on the connection between influenza and heart attacks. He discusses the challenges of running large-scale observational studies, the bureaucratic barriers to accessing medical data, and the importance of diversity in health research. Salah also reflects on his early entrepreneurial ventures, his discovery of programming during medical school, and how resilience and adaptability shaped his personal and professional journey.00:00 Introduction02:03 Research on Influenza and Heart Attacks05:53 Challenges in Data Access16:51 Life in Libya Under Gaddafi21:32 From Medicine to Programming41:18 WHO Collaboration and Education Abroad57:13 Disappearance and New Beginnings01:09:33 Immigration and Adaptation in Canada01:15:45 Balancing Medicine and Technology01:21:22 Family, Culture, and Reflection01:25:37 Current Research and Future GoalsConnect with Salah: Email: salah.mahmud@umanitoba.caLinkedIn: https://www.linkedin.com/in/salah-mahmud-4177285a/Mentioned in this Episode:Golang: https://go.dev/Want more from Ardan Labs? You can learn Go, Kubernetes, Docker & more through our video training, live events, or through our blog!Online Courses : https://ardanlabs.com/education/ Live Events : https://www.ardanlabs.com/live-training-events/ Blog : https://www.ardanlabs.com/blog Github : https://github.com/ardanlabs

For decades, medical research has been built around male data — leaving women dangerously underrepresented in clinical trials, drug development, and symptom understanding. The result? Misdiagnoses, ineffective treatments, and life-threatening blind spots in women's healthcare.In this episode, Sonja Rincon, CEO and founder of MenoTracker, reveals how artificial intelligence is finally beginning to close the gender data gap in medicine. By using AI-powered analytics, machine learning, and real-world data, her platform is transforming how we understand perimenopause, menopause, and the broader landscape of women's health research.Sonja explains how AI can:Detect patterns in women's symptoms that doctors miss due to limited time and fragmented dataUse mobile health apps, wearables, and electronic health records to build inclusive, large-scale data setsAddress bias in healthcare algorithms and promote diversity in AI training dataEnable personalised medicine and tailored treatments for womenEmpower women to track, understand, and advocate for their healthFrom uncovering why AI algorithms have racial and gender bias to reimagining perimenopause tracking for 177 countries, this episode is a must-listen for anyone passionate about the future of AI in healthcare, digital health innovation, and gender equality in medicine.Sonja also highlights shocking realities — like how 58% of medical textbooks don't cover menopause — and how AI can shorten the average diagnosis time for perimenopause from 7.4 years to just days.Whether you're a healthcare innovator, data scientist, or simply someone who believes in inclusive innovation, this episode will reshape how you think about AI's role in women's health.About the PodcastAI for Pharma Growth is a podcast focused on exploring how artificial intelligence can revolutionise healthcare by addressing disparities and creating equitable systems. Join us as we unpack groundbreaking technologies, real-world applications, and expert insights to inspire a healthier, more equitable future.This show brings together leading experts and changemakers to demystify AI and show how it's being used to transform healthcare. Whether you're in the medical field, technology sector, or just curious about AI's role in social good, this podcast offers valuable insights.AI For Pharma Growth is the podcast from pioneering Pharma Artificial Intelligence entrepreneur Dr. Andree Bates created to help organisations understand how the use of AI based technologies can easily save them time and grow their brands and business. This show blends deep experience in the sector with demystifying AI for all pharma people, from start up biotech right through to Big Pharma. In this podcast Dr Andree will teach you the tried and true secrets to building a pharma company using AI that anyone can use, at any budget. As the author of many peer-reviewed journals and having addressed over 500 industry conferences across the globe, Dr Andree Bates uses her obsession with all things AI and futuretech to help you to navigate through the, sometimes confusing but, magical world of AI powered tools to grow pharma businesses. This podcast features many experts who have developed powerful AI powered tools that are the secret behind some time saving and supercharged revenue generating business results. Those who share their stories and expertise show how AI can be applied to sales, marketing, production, social media, psychology, customer insights and so much more. Dr. Andree Bates LinkedIn |

Dr. Alan Rozanski, a distinguished Professor of Medicine at the Icahn School of Medicine at Mount Sinai and Director of Nuclear Cardiology at Mount Sinai St. Luke's in New York City, details the holistic aspects of medicine, emphasizing the integrative approach involving lifestyle, mental health, exercise, and the psychological dimensions of heart health. Dr. Rozanski reveals the six domains of optimal health and vitality, sharing insights from his pioneering work in integrating such approaches into cardiology, the significant impact of stress, and the importance of maintaining a sense of life purpose and social connections. He also delves into modern imaging techniques, the utility of coronary artery calcium scores, and emerging treatments like GLP-1 drugs for cardiovascular health. The conversation provides a thorough exploration of comprehensive health management strategies beyond just medication and surgery.

Dr. Hoffman continues his conversation with Dr. Alan Rozanski, a distinguished Professor of Medicine at the Icahn School of Medicine at Mount Sinai and Director of Nuclear Cardiology at Mount Sinai St. Luke's in New York City.

In this episode my guest is Dr. Kevin J. Tracey and we are discussing one of the most fascinating and revolutionary discoveries in modern medicine — the link between the vagus nerve, the inflammatory reflex, and the body's innate ability to heal. For years, inflammation has been seen as a silent driver behind chronic illness — from autoimmune disease and depression to heart disease and neurodegeneration. But what if the body already has a built-in mechanism to control it? Dr. Tracey is the president and CEO of the Feinstein Institutes for Medical Research at Northwell Health, a pioneer of vagus nerve research and author of The Great Nerve. A leader in the scientific fields of inflammation and neuroscience, his lab studies vagus nerve stimulation and bioelectronic medicine. His contributions include first identifying the therapeutic action of monoclonal anti-TNF antibodies and discovering the specific reflex control of immunity by the nervous system, called the “inflammatory reflex.” These discoveries launched the new scientific field called bioelectronic medicine, which investigates the therapeutic applications of vagus nerve stimulation to cure disease. Dr. Tracey, a neurosurgeon, pursued studies of inflammation after the mysterious death of a toddler from sepsis who was in his care. His lab has since revealed molecular mechanisms of inflammation and identified the use of vagus nerve stimulation to treat it. An inventor on more than 120 U.S. patents and the author of more than 450 scientific publications, he is among the most highly cited scientists in the world. He co-founded the Global Sepsis Alliance, is the author of Fatal Sequence (Dana Press) and is a national and international lecturer. Learning Points: • What is the vagus nerve? • What is the link between the vagus nerve, the inflammatory reflex, and the body's innate ability to heal? • What is bioelectronic medicine? Social Media: • X: https://x.com/KevinJTraceyMD • LinkedIn: https://www.linkedin.com/in/kevinjtraceymd • Website: https://feinstein.northwell.edu/

In this Review Series episode, Associate Editor Dr. Philippe Armand speaks with multiple authors about what it might look like to improve treatments follicular lymphoma, a disease that has been put on the backburner of innovation due to its generally treatable nature. Dr. Armand discusses "Treatment of relapsed and refractory follicular lymphoma: which treatment for which patient for which line of therapy?" with author Dr. Carla Casulo,  "The future of follicular lymphoma management: strategies on the horizon” with author Dr. Sarah C. Rutherford, and "An updated understanding of follicular lymphoma transformation” with Dr. Erin M. Parry.Find the whole review series on follicular lymphoma in volume 146 issue 15 of Blood Journal.  

This week, we look at new findings from the European prostate cancer screening study, advances in lung cancer therapy, physical therapy for meniscal tear, and a promising vaccine for Salmonella Paratyphi A. We review noninvasive liver fibrosis assessment and a complex clinical case, and explore perspectives on concierge care, kidney disease equity, WIC enrollment, community health, FDA regulation, and standing with colleagues in Gaza.

In this episode, Peter and Leon, recording at the College of Intensive Care Medicine's Conference in Tasmania, Australia, discuss advancements in precision medicine with Dr. Pratik Sinha from Washington University in St. Louis. Dr Pratik trained in both Emergency and Intensive Care Medicine, but only works clinically as an intensivist. He runs a research program that seeks to change the way we identify and classify critically ill patients, by using a combination of novel biological measurements and state of the art data science approaches. The conversation delves into how critical care medicine currently operates, emphasizing the need to shift from supportive care to more personalized approaches using biological measuring systems, big data, and novel data science techniques. They discuss identifying patient subgroups using machine learning algorithms and protein biomarkers, revealing phenotypes like hyper and hypo-inflammatory responses. The discussion covers the practical challenges of implementing these technologies, the importance of rigorous testing, and the future implications for intensive care. The speakers highlight the necessity of prospective clinical trials and broader accessibility of these advanced diagnostic tools to improve patient outcomes.00:00 Introduction and Opening Remarks00:34 Diving into Precision Medicine01:35 Elevator Pitch for Medical Research02:10 Understanding Patient Complexity04:12 Biological Measurements and Data Science10:37 Challenges in Modern Medicine17:08 Future of Medical Research and AI21:20 Concluding Thoughts and Future Prospects

An electronic eye implant half the thickness of a human hair has helped people with incurable sight loss to see again, opening up a potential ‘new era' in tackling blindness. Madeleine Finlay hears from Mahi Muqit, a surgeon from Moorfields eye hospital in London, about what this implant has meant for his patients and what the future could hold for vision-loss therapies. Help support our independent journalism at theguardian.com/sciencepod

In this week's episode of the Blood Podcast, Associate Editor Dr. James Griffin interviews Drs. Binod Dhakal and Ruben Bierings about their respective papers published in this week's issue of Blood. Dr. Dhakal presents his study on using talquetamab, a bispecific antibody, as a bridging therapy before BCMA-targeted CAR T-cell therapy in multiple myeloma patients, showing promising results with high response rates and manageable toxicities. Next, Dr. Bierings identified patients with genetic variants in the guanine exchange factor MAP kinase–activating death domain (MADD) that impair VWF secretion from endothelial cells and possibly cause VWD type 1. Featured ArticlesA novel cause of type 1 von Willebrand disease: impaired exocytosis of Weibel-Palade bodies due to biallelic MADD variantsSophie Hordijk, Stijn A. Groten, Petra E. Bürgisser, Sebastiaan N. J. Laan, Georg Christoph Korenke, Tomáš Honzík, Diane Beysen, Frank W. G. Leebeek, Paul A. Skehel, Maartje van den Biggelaar, Tom Carter, Ruben BieringsSequential targeting in multiple myeloma: talquetamab, a GPRC5D bispecific antibody, as a bridge to BCMA CAR-T therapyBinod Dhakal, Othman S. Akhtar, David Fandrei, Alexandria Jensen, Rahul Banerjee, Darren Pan, Shambavi Richard, Reed Friend, Matthew Rees, Patrick Costello, Mariola Vazquez Martinez, Oren Pasvolsky, Charlotte Wagner, James A. Davis, Omar Castaneda Puglianini, Ran Reshef, Aimaz Afrough, Danai Dima, Manisha Bhutani, Omar Nadeem, Ricardo Parrondo, Ciara Freeman, Lekha Mikkilineni, Shahzad Raza, Larry D. Anderson Jr, Prashant Kapoor, Hitomi Hosoya, Saurabh Chhabra, Ariel Grajales-Cruz, Mahmoud Gaballa, Shonali Midha, Melissa Alsina, Douglas Sborov, Krina Patel, Yi Lin, Christopher Ferreri, Nico Gagelmann, Anupama Kumar, Doris Hansen, Andrew Cowan, Luciano J. Costa, Maximilian Merz, Surbhi Sidana

In this episode, we look at new research on mucoactive therapy for bronchiectasis, aspirin use in anticoagulated patients with coronary disease, and sotatercept for early pulmonary arterial hypertension. We explore the genetics behind misdiagnosed common diseases and review uncertainty in medical training. We also share a case of woman with abdominal distention, edema, and pleural effusions and Perspectives on sickle cell disease, fetal personhood, and living with a genetic diagnosis.

As Japan declares a flu epidemic we find out more about what's going on in the country, and the potential implications for the flu season ahead in the Northern Hemisphere.Human and bot imposters are rising in medical research, and they risk undermining results, but why do they do it? Eileen Morrow from the University of Oxford explains the tricky balance of safeguarding against them whilst not excluding real participants. A new adrenaline nasal spray has been licenced for those with severe allergies. Family Doctor Ayan Punja explains what a difference this might make for patients.The first patient has been recruited in a phase III trial investigating malaria treatments in early pregnancy. We speak to her and the researchers who are hoping to recruit further participants in Mali, Burkina Faso and Kenya.Plus, how far can you really push yourself? Researchers think they've found the ‘metabolic ceiling' for endurance athletes.Presenter: Claudia Hammond Producers: Katie Tomsett and Hannah Robins

New options for knee pain—radiation and embolization; Popeye was right to power-up with spinach; Conquering inflammation; Methane-predominant SIBO; Unnecessary back surgery on seniors is rampant; Medicare Advantage patients often relegated to inferior cancer surgery. 

When motivation disappears and perfectionism takes over, most people shut down. Casey Beros learned the opposite approach. We talk about how to stop waiting for the perfect time, why momentum matters more than motivation, and the small daily actions that can rebuild your health and mindset when you feel stuck.Timestamps: (00:00) Overcoming Perfectionism(00:32) Introduction(01:35) Casey's Journey(02:47) The Fascination with Health and Wellbeing(06:37) Navigating the Healthcare System(07:46) The Role of Influencers in Health Communication(09:58) Finding Credible Health Information(13:32) Casey's Book - Next of Kin(15:57) The Impact of Being a Carer(21:25) The Importance of Intergenerational Care(25:13) Challenges in the Healthcare System(29:55) The Need for Preventative Care(31:45) Preventative Approaches in Healthcare(32:04) The Slow Pace of Medical Research(32:52) The Impact of AI on Medicine(33:49) Innovative Mental Health Solutions in the UK(35:19) Caring for Carers - Mental and Physical Health Tips(38:38) The Importance of Social and Spiritual Wellbeing(42:17) Momentum Over Motivation(45:17) The Burden of Caregiving and Health Debt(49:13) Action Cures Inaction(50:29) Closing Thoughts and ReflectionsAccess FREE Move Your Mind training here:https://go.moveyourmind.io/trainingConnect with Nick:Instagram: https://instagram.com/nickbracksWebsite: http://nickbracks.comEmail: contact@nickbracks.com Hosted on Acast. See acast.com/privacy for more information.

In this episode, Anousha is joined by Dr. Su Wang, Medical Director of the Chinese Medical Program at Cooperman Barnabas Medical Center and Medical Advisor to the Hepatitis B Foundation, along with Dr. Thomas Tu, Molecular Biologist at the Westmead Institute for Medical Research in Australia. Together, they discuss expanding hepatitis B treatment guidelines by broadening eligibility criteria, improving access, reducing loss to follow-up, and the importance of including public health and patient perspectives in guideline development. Read more about their new paper here: https://pubmed.ncbi.nlm.nih.gov/40714036/Support the showOur website: www.hepb.orgSupport B Heppy!Social Media: Instagram - Twitter - Facebook

Australia has its first new cancer screening programme in 20 years, this time for lung cancer. Today we'll be discussing this new programme in depth as well as the role of primary care and the supports available in delivering the programme.This podcast is Sponsored by the Australian Government National Lung Cancer Screening Program.Professor Vivienne Milch is Medical Director, at Cancer Australia. Professor Milch is also Medical Advisor to the Australian Commonwealth Department of Health, Disability and Ageing on cancer screening policy.Professor Milch holds a Master's degree in Health Policy and is an Adjunct Clinical Associate Professor in the School of Medicine, Sydney Campus at The University of Notre Dame, Australia and Professorial Fellow at the Caring Futures Institute at Flinders University in Adelaide. Prior to joining Cancer Australia, Professor Milch was a General Practitioner and clinical researcher at the Garvan Institute of Medical Research, Sydney. Relevant links: the Investigating Symptoms of Lung Cancer guide Healthcare Provider Toolkit The NLCSP website Program Guidelines GP guide resource Reducing stigma in the program Low-dose CT Scan request form eLearning modules developed by Lung Foundation Australia Actionable additional findings guidelines

In this Spotlight series episode on Acute Myeloid Leukemia, Blood Editor, Dr. Selina Luger interviews Drs. Laura Michaelis and Alexander Perl on their paper in the series titled “The fit older adult with acute myeloid leukemia: clinical challenges to providing evidence-based frontline treatment”. The conversation explores challenges in treating AML across different patient populations. They also focus on treatment approaches for fit older adults with AML, highlighting the need for less toxic therapies and ongoing randomized trials to better understand treatment efficacy. See the full spotlight series on Acute Myeloid Leukemia in Volume 145 Issue 24 of Blood journal. 

In this episode, we look at new research in cervical cancer, lupus, gene therapy for immune deficiency, and malaria prevention in infants. We review hair loss in women, follow a case of tuberculosis in advanced HIV, and hear perspectives on vaccines, primary care, digital health, infection surveillance, AI in disaster response, Medicare policy, and bearing witness in conflict zones.

On this episode of JHLT: The Podcast, the Digital Media Editors invite co-lead author Nir Uriel, MD, Director of Advanced Heart Failure and Cardiac Transplantation at New York Presbyterian Hospital and Professor of Medicine at Columbia University. Dr. Uriel joins to discuss the work of the Cardiogenic Shock Working Group (CSWG) and their recent paper, “Outcomes of patients supported on Impella 5.5 for more than 14 days: A Cardiogenic Shock Working Group registry analysis.” The discussion explores: Why patients on longer duration of MCS had better survival but maintained similar rates of serious adverse events (SAEs) Why the study might show fewer SAEs than the literature historically shows How temporary MCS devices are selected in clinical settings in patients with cardiogenic shock The ongoing and upcoming activities of CSWG For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt. Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

In this week's episode we'll learn more about a study comparing busulfan-melphalan with melphalan alone as the conditioning protocol for newly diagnosed, transplant-eligible multiple myeloma; then we will discuss data on how three-dimensional transcriptomics can reveal complex interactions between plasma cells and bone marrow microenvironments.Featured ArticlesHigh-dose busulfan-melphalan vs melphalan and reinforced VRD for newly diagnosed multiple myeloma: a phase 3 GEM trialProfiling the spatial architecture of multiple myeloma in human bone marrow trephine biopsy specimens with spatial transcriptomicsPreclinical advances in glofitamab combinations: a new frontier for non-Hodgkin lymphoma

In this episode, we explore new treatments for hypertension, hereditary amyloidosis, and malaria prevention, along with insights on mosquito-borne disease control. We review idiopathic intracranial hypertension, follow a striking case of a hidden foreign body, and hear perspectives on worker safety, immigrant health care, the role of pharmaceutical wholesalers, and the arc of a medical career.

Ladies, it's Breast Cancer Awareness Month, so go get your boobies checked! We're also talking family lineage, growing up on a farm, and the groundbreaking treatment for Huntington's disease.00:00:00 - Introduction & Getting Started 00:02:04 - Fall Season & Halloween Decorations Debate 00:05:27 - Big Tea & Do Dog (Parent Nicknames) 00:15:27 - Big Family Reflections 00:20:08 - Family Genealogy & Lineage00:24:11 - Pop Culture & Science Discussion00:30:16 - Gene Therapy & Medical Research 00:33:07 - Eric Dane & ALS Awareness 00:37:11 - mRNA Vaccine Technology 00:38:36 - Wrapping Up & Superpower TalkMORE PODCAST EPISODES: https://youtube.com/playlist?list=PLTGuNbPgq2EartAwwgs_H-LVho3FvWnXpJUST LISTEN TO THE PODCAST: https://link.chtbl.com/imomsohardSEE US ON TOUR: (FALL DATES COMING SOON)https://www.imomsohard.com/WATCH OUR AMAZON PRIME SPECIAL: https://www.amazon.com/IMomSoHard-Live/dp/B07VBJ34DTIf you are interested in advertising on this podcast email ussales@acast.comTo request #IMOMSOHARD to be on your Podcast, Radio Show, or TV Show, reach out to talent@pionairepodcasting.comFOLLOW US: Facebook: https://www.facebook.com/imomsohardInstagram: https://www.instagram.com/imomsohard/Twitter: https://twitter.com/imomsohardGet our sponsor DISCOUNT CODES here!https://linktr.ee/imshpodcastABOUT US Female comedy duo Kristin Hensley and Jen Smedley have been performing, teaching, and writing comedy internationally for a combined 40+ years. They have been moms for one quarter of that time and it shows. How do they cope? They laugh about all of the craziness that comes with being a mom and they want you to laugh about it too! From snot to stretchmarks to sleepless nights, Kristin and Jen know firsthand that parenting is a hard job and they invite you to join them in taking it all a little less seriously (even if for a few short minutes a day). After all, Jen currently has four days of dry shampoo in her hair and Kristin's keys are still in her front door. They try, they fail, they support each other, and they mom as hard as they can.Disclaimer: This podcast is for entertainment purposes only. Views expressed on this podcast solely reflect those of the host and do not reflect the views of Pionaire. Hosted on Acast. See acast.com/privacy for more information.

The Guardian journalist Josh Halliday talks about Huntington's disease, the impact the rare inherited condition has had on his family and the hope there may now be a treatment. Help support our independent journalism at theguardian.com/infocus

In this expert interview, I sit down with Dr. Kevin Tracey—pioneer of the “inflammatory reflex” and a leading voice on neuroimmune science—to unpack how your nervous system can dial inflammation up or down. We explore what's really driving inflammatory arthritis, why the vagus nerve is a key switch for immune balance, and how neuromodulation (yes, stimulating nerves!) is opening new, drug-sparing frontiers for pain and flare control. You'll learn the difference between protective vs. destructive inflammation, practical ways to support vagal tone, and what the latest research means for people living with autoimmune and inflammatory conditions. If you've wondered how the brain, immune system, and joints talk to each other, this conversation connects the dots—and offers hope. Kevin J. Tracey, MD, is president and CEO of the Feinstein Institutes for Medical Research at Northwell Health, a pioneer of vagus nerve research and author of The Great Nerve. A leader in the scientific fields of inflammation and neuroscience, his lab studies vagus nerve stimulation and bioelectronic medicine. His contributions include first identifying the therapeutic action of monoclonal anti-TNF antibodies and discovering the specific reflex control of immunity by the nervous system, called the “inflammatory reflex.” These discoveries launched the new scientific field called bioelectronic medicine, which investigates the therapeutic applications of vagus nerve stimulation to cure disease. Dr. Tracey, a neurosurgeon, pursued studies of inflammation after the mysterious death of a toddler from sepsis who was in his care. His lab has since revealed molecular mechanisms of inflammation and identified the use of vagus nerve stimulation to treat it. An inventor on more than 120 U.S. patents and the author of more than 450 scientific publications, he is among the most highly cited scientists in the world. He co-founded the Global Sepsis Alliance, is the author of Fatal Sequence (Dana Press) and is a national and international lecturer. Check out Dr. Tracey's Ted Talk here:https://www.youtube.com/watch?v=AJH9KsMKi5M Free consultation with me and check out my memership with essential oils program: http://essentialwellnesscircle.com Follow me on instagram: https://instagram.com/annalaurabrownwellness Youtube channel with videos of this podcast and more: https://youtube.com/c/annalaurabrownhealthcoach    

Scientists are warning that academic publishing needs urgent reform in order to retain trust in the research system. Ian Sample tells Madeleine Finlay what has gone so wrong, and Dr Mark Hanson of the University of Exeter proposes some potential solutions. Help support our independent journalism at theguardian.com/sciencepod

Due to President Trump's sweeping federal cuts to medical research, many colleges and universities are faced with financial uncertainty. Why does the government want to make cuts to medical/science research? How worried are you about delays in potentially lifesaving research? UMass Chan Medical School Chancellor Dr. Michael F. Collins joined us on NightSide to discuss.

Featuring articles on severe acute malnutrition with gastroenteritis in children, medical imaging and pediatric cancer risk, moderate hypertriglyceridemia, preventing RSV disease in healthy infants, and treating hypertension in rural South Africa; a review article on monoclonal gammopathy of undetermined significance; a Clinical Problem-Solving on a shifting frame; and Perspectives on insight into corporate governance, on pharmaceutical tariffs, and on OUD medications.

On this episode of JHLT: The Podcast, the Digital Media Editors invite author Dr. Ayumi Goda, from the Kyorin University Hospital in Tokyo, Japan, to discuss her team's paper, “Prevalence of occult HFpEF and age-specific efficacy of passive leg raise in pulmonary hypertension.” The discussion explores: How clinical observations led to the idea for a study on whether the passive leg raise could unmask occult HFpEF The potential diagnostic value of the passive leg raise in differing patient populations Age-specific cutoffs that may influence what kind of testing to use in clinical practice For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt. Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

Subscribe to the video podcast: https://www.youtube.com/@DrTazMD/podcastsWhat if the birth control you're taking every day is quietly changing your brain, your mood, your relationships—and even who you're attracted to? In this groundbreaking episode of hol+, Dr. Taz MD sits down with award-winning researcher and author Dr. Sarah Hill (This Is Your Brain on Birth Control) to reveal the shocking, little-known science of how hormonal contraception shapes not just your reproductive system, but your entire mind and body.From altered stress responses to shifts in attraction, depression risk in teens, and the controversial “bikini science” problem in medical research, Dr. Hill pulls back the curtain on decades of overlooked studies that every woman and parent should know about. She shares her own journey from evolutionary psychologist to outspoken women's health advocate, explaining why synthetic progestins are not the same as progesterone, how birth control affects your immune system, and why teenagers may be especially vulnerable to its mental health effects.If you're a woman in your teens, 20s, 30s, or 40s—or a parent guiding your daughter—this episode could change the way you think about hormone health, fertility, and your body's natural rhythms.Dr. Hill and Dr. Taz discuss:How birth control changes the brain's structure and functionThe difference between progesterone and synthetic progestins (and why it matters)Why “bikini science” has failed women in medical researchThe surprising link between birth control and partner attractionThe immune system's hidden connection to hormonal cyclingTeen mental health risks: depression, anxiety, and brain developmentSafer contraceptive choices and how to support your body if you use the pillHow nutrition and micronized progesterone might help offset side effectsThis conversation is more than just information — it's a wake-up call for how we study, prescribe, and support women's health.Topics Covered:Hormonal birth control's impact on the brainSynthetic hormones vs. bioidentical hormonesPartner choice and relationship satisfaction researchAutoimmunity and immune system differences in womenMental health risks for adolescent usersNon-hormonal birth control optionsNutritional and hormonal support strategiesConnect further to Hol+ at https://holplus.co/- Don't forget to like, subscribe, and hit the notification bell to stay updated on future episodes of hol+.About Dr. Sarah E. HillSarah E. Hill, Ph.D., is the author of This is Your Brain on Birth Control and an award-winning researcher who has spent most of her 20+ year career studying women, relationships, and health. In addition to having established an award-winning health and relationships lab at TCU, she has published nearly 100 academic research articles, is a sought-after public speaker, and sits on the scientific advisory boards for women's health companies such as Flo and 28 Wellness. Her research is regularly covered by national media, such as The Washington Post, The New York Times, and many others, and is regularly published in highly prestigious journals, including Journal of Personality and Social Psychology, Psychoneuroendocrinology, Psychological Science, and Health Psychology.Stay ConnectedSubscribe to the audio podcast: https://holplus.transistor.fm/subscribeSubscribe to the video podcast: https://www.youtube.com/@DrTazMD/podcastsFollow Dr. Taz on Instagram: https://www.instagram.com/drtazmd/https://www.instagram.com/liveholplus/Join the conversation on X: https://x.com/@drtazmdTikTok: https://www.tiktok.com/@drtazmdFacebook: https://www.facebook.com/drtazmd/Connect with Dr. Sarah E. Hill:https://www.sarahehill.com/https://www.instagram.com/sarahehillphdHost & Production TeamHost: Dr. Taz; Produced by Rainbow Creative (Executive Producer: Matthew Jones; Lead Producer: Lauren Feighan; Editors: Jeremiah Schultz and Patrick Edwards)Don't forget to like, subscribe, and hit the notification bell to stay updated on future episodes of hol+Chapters00:00 Introduction06:12 The Flaws in Medical Research on Women17:51 Dr. Hill's Personal Journey with Birth Control21:43 The Science Behind Birth Control's Effects on the Brain27:45 How Birth Control Influences Attraction and Relationships34:44 Impact of Birth Control on Relationship Satisfaction37:31 Divorce Rates and Birth Control40:12 Hormones and Brain Influence41:35 Hormone Replacement Therapy (HRT): Progesterone vs. Progestin47:57 Birth Control and Mental Health in Teens01:00:16 Conclusion and Final Thoughts

Dr. Hoffman continues his conversation with Nicole Bell, the CEO of Galaxy Diagnostics and author of “What Lurks in the Woods.” 

This episode of the Intelligent Medicine podcast is a deep dive into the complexities of Lyme disease and other tick-borne illnesses. Nicole Bell, the CEO of Galaxy Diagnostics and author of “What Lurks in the Woods,” details the challenges of diagnosing tick-borne diseases, the limitations of current diagnostic tests, and the controversy around treatment methodologies. Nicole shares her personal journey that led her to this field after her husband was misdiagnosed with early-onset Alzheimer's, which was later revealed to be caused by advanced Lyme disease. They also discuss new diagnostic techniques, the importance of personalized treatment plans, and ongoing advocacy efforts to improve awareness and research funding for Lyme disease.

When the US president stood up at the podium and announced a link between autism and paracetamol, he sent alarm through the medical community and the public. Guardian science correspondent Hannah Devlin speaks to Reged Ahmad about what the science actually says about the painkiller and why experts fear Donald Trump is deliberately fostering a narrative of distrust

Hotel Mars with Ben Roberts for Sept. 24, 2025Summary by Zoom. Edited.This Hotel Mars program featured a discussion microgravity investor Ben Roberts about the applications and investments in microgravity technology, including its impact on medical treatments, drug formulations, and material sciences. We explored the progress and challenges of commercial space companies in microgravity research and production, with NASA's support programs playing a crucial role in their development. The conversation covered various applications of low microgravity, the competitive landscape of the industry, and the timeline for product development and market entry.John Batchelor welcomed Ben Roberts, an investor in microgravity, to discuss the applications and investments in microgravity technology. Ben explained that microgravity refers to the limited effect of gravity in orbit, which enables innovative applications in medical treatments, drug formulations, and material sciences. He highlighted examples such as creating artificial limbs, developing new drugs, and producing high-quality materials that are not possible on Earth due to gravity's interference. Ben clarified that microgravity applies to any orbit with low enough gravity to affect living systems and material defects, but not enough to eliminate sedimentation or convection.Ben discussed the progress and challenges of commercial space companies, particularly those involved in microgravity research and production. While basic research on space shuttles and the ISS has been ongoing for decades, commercial companies like Varda and Redwire are just beginning to reach commercialization, producing medical seed crystals and elements. He noted that NASA's support through programs like SBIR has been crucial in helping these companies transition from pre-commercial to operational phases. The discussion also touched on the financial challenges these companies face, suggesting that private sector or government investment might be needed to bridge the gap until traditional VCs become involved once commercial viability is proven.Ben continued to discuss various applications of low microgravity, including advanced nanoparticles for drug delivery, accelerated aging studies, and 3D printed cardiac tissue. He explained how these technologies could be more effective when produced in space, despite higher costs. The panelists agreed that while some products could reach the market in 2-5 years, those requiring FDA approval might take longer, with significant progress expected by the 2030s.Special thanks to our sponsors:Northrup Grumman, American Institute of Aeronautics and Astronautics, Helix Space in Luxembourg, Celestis Memorial Spaceflights, Astrox Corporation, Dr. Haym Benaroya of Rutgers University, The Space Settlement Progress Blog by John Jossy, The Atlantis Project, and Artless EntertainmentOur Toll Free Line for Live Broadcasts: 1-866-687-7223For real time program participation, email Dr. Space at: drspace@thespaceshow.comThe Space Show is a non-profit 501C3 through its parent, One Giant Leap Foundation, Inc. To donate via Pay Pal, use:To donate with Zelle, use the email address: david@onegiantleapfoundation.org.If you prefer donating with a check, please make the check payable to One Giant Leap Foundation and mail to:One Giant Leap Foundation, 11035 Lavender Hill Drive Ste. 160-306 Las Vegas, NV 89135Upcoming Programs: Get full access to The Space Show-One Giant Leap Foundation at doctorspace.substack.com/subscribe

The US health secretary, Robert F Kennedy Jr, has long been consumed by the neurological condition autism – what causes it, and whether there's a treatment. This week, Donald Trump took on the cause, making claims about acetaminophen, also known as Tylenol and paracetamol, that were dismissed outright by medical experts around the world. Jonathan Freedland speaks to Carter Sherman, the reproductive health and justice reporter at Guardian US, about when and why the obsession with autism became political

Featuring articles on heart failure, provoked venous thromboembolism, chronic lymphocytic leukemia, and acute ischemic stroke; a review article on medical education to improve diagnostic equity; a case report of a man with embolic stroke and left ventricular apical aneurysm; two articles on the 2025 Lasker–DeBakey Clinical Medical Research Award; and Perspectives on structural and scientific racism, on the Gates Foundation's final chapter, and on Dr. Kolhouse and the cowboy.

A trial is under way to find out if a £100 blood test could transform the way that the NHS diagnoses Alzheimer's disease. Alzheimer's is the leading cause of dementia and diagnosis is currently costly and time-consuming. To find out how this blood test could benefit patients, Ian Sample talks to Prof Jonathan Schott, who is co-leading the trial. He explains what the test involves and why it could pave the way for exciting new treatments for the devastating disease. Help support our independent journalism at theguardian.com/sciencepod

Kevin J. Tracey, MD is president and CEO of the Feinstein Institutes for Medical Research at Northwell Health, a pioneer of vagus nerve research and author of the recent book, The Great Nerve: The New Science of the Vagus Nerve and How to Harness Its Healing Reflexes. This episode is brought to you by:Eight Sleep Pod Cover 5 sleeping solution for dynamic cooling and heating: EightSleep.com/Tim (use code TIM to get $350 off your very own Pod 5 Ultra.)AG1 all-in-one nutritional supplement: https://DrinkAG1.com/Tim (1-year supply of Vitamin D plus 5 free AG1 travel packs with your first subscription purchase.)Wealthfront high-yield cash account: https://Wealthfront.com/Tim (Start earning 4.00% APY on your short-term cash until you're ready to invest. And when new clients open an account today, you can get an extra fifty-dollar bonus with a deposit of five hundred dollars or more.) Terms apply. Tim Ferriss receives cash compensation from Wealthfront Brokerage, LLC for advertising and holds a non-controlling equity interest in the corporate parent of Wealthfront Brokerage. See full disclosures here.Timestamps:00:00 Tim's intro: why he dismissed vagus-nerve hype06:34 What the vagus nerve actually is, plus common myths11:31 Breaking news: FDA approval for SetPoint's RA implant + Kelly Owens's turnaround21:11 Inflammation 101: when healing turns harmful31:37 Bioelectronic medicine: from lab insight to real devices55:26 TNF, IL-1, and IL-6: immune drivers and what VNS modulates56:06 Exercise & recovery: vagal signals, IL-6, and adaptation56:30 Cold exposure & breathwork: sympathetic spike, parasympathetic payoff59:04 Chronic inflammation today: prevalence, diagnostics, and uncertainty59:53 Autoimmunity: genes, environment, infections01:01:08 Stress hormones, personality traits, and metabolic fallout01:05:41 VNS tech landscape: implants, focused ultrasound, and what's just TENS01:11:14 Ear maps, revisited: the real science behind auricular stimulation01:27:52 Ulf Andersson: auricular TENS, famotidine, and a depression turnaround01:36:48 Depression & inflammation: where VNS helps (and where it doesn't)01:41:38 Body-brain loop: how inflammation signals ride the vagus nerve01:42:56 Why VNS can lift mood: a working theory01:43:22 Ulf's setup: electrode placement and twice-daily routine01:44:37 Acupuncture, fertility, and plausible vagal links01:47:23 Chronic pain through an inflammation lens01:48:34 Neural “engrams”: how the brain can store inflammatory memories02:02:35 Cervical TENS vs. true VNS: mechanisms and open questions02:12:15 On stage with the Dalai Lama: blue energy and two vagus nerves02:16:55 Closing thoughts: self-care vs. medical devices, and what's next*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim's email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim's books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, Margaret Atwood, Mark Zuckerberg, Peter Thiel, Dr. Gabor Maté, Anne Lamott, Sarah Silverman, Dr. Andrew Huberman, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.