Podcasts about Medical research

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Best podcasts about Medical research

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Latest podcast episodes about Medical research

NEJM This Week — Audio Summaries
NEJM This Week — October 30, 2025

NEJM This Week — Audio Summaries

Play Episode Listen Later Oct 29, 2025 25:27


This week, we look at new findings from the European prostate cancer screening study, advances in lung cancer therapy, physical therapy for meniscal tear, and a promising vaccine for Salmonella Paratyphi A. We review noninvasive liver fibrosis assessment and a complex clinical case, and explore perspectives on concierge care, kidney disease equity, WIC enrollment, community health, FDA regulation, and standing with colleagues in Gaza.

The Critical Care Commute Podcast
Precision Medicine - It may be easier than you think!

The Critical Care Commute Podcast

Play Episode Listen Later Oct 29, 2025 31:02


In this episode, Peter and Leon, recording at the College of Intensive Care Medicine's Conference in Tasmania, Australia, discuss advancements in precision medicine with Dr. Pratik Sinha from Washington University in St. Louis. Dr Pratik trained in both Emergency and Intensive Care Medicine, but only works clinically as an intensivist. He runs a research program that seeks to change the way we identify and classify critically ill patients, by using a combination of novel biological measurements and state of the art data science approaches. The conversation delves into how critical care medicine currently operates, emphasizing the need to shift from supportive care to more personalized approaches using biological measuring systems, big data, and novel data science techniques. They discuss identifying patient subgroups using machine learning algorithms and protein biomarkers, revealing phenotypes like hyper and hypo-inflammatory responses. The discussion covers the practical challenges of implementing these technologies, the importance of rigorous testing, and the future implications for intensive care. The speakers highlight the necessity of prospective clinical trials and broader accessibility of these advanced diagnostic tools to improve patient outcomes.00:00 Introduction and Opening Remarks00:34 Diving into Precision Medicine01:35 Elevator Pitch for Medical Research02:10 Understanding Patient Complexity04:12 Biological Measurements and Data Science10:37 Challenges in Modern Medicine17:08 Future of Medical Research and AI21:20 Concluding Thoughts and Future Prospects

Science Weekly
The ‘remarkable' implant that can restore sight

Science Weekly

Play Episode Listen Later Oct 23, 2025 15:19


An electronic eye implant half the thickness of a human hair has helped people with incurable sight loss to see again, opening up a potential ‘new era' in tackling blindness. Madeleine Finlay hears from Mahi Muqit, a surgeon from Moorfields eye hospital in London, about what this implant has meant for his patients and what the future could hold for vision-loss therapies. Help support our independent journalism at theguardian.com/sciencepod

Blood Podcast
Breakthroughs in Multiple Myeloma Treatment and Von Willebrand Disease Mechanisms

Blood Podcast

Play Episode Listen Later Oct 23, 2025 24:11


In this week's episode of the Blood Podcast, Associate Editor Dr. James Griffin interviews Drs. Binod Dhakal and Ruben Bierings about their respective papers published in this week's issue of Blood. Dr. Dhakal presents his study on using talquetamab, a bispecific antibody, as a bridging therapy before BCMA-targeted CAR T-cell therapy in multiple myeloma patients, showing promising results with high response rates and manageable toxicities. Next, Dr. Bierings identified patients with genetic variants in the guanine exchange factor MAP kinase–activating death domain (MADD) that impair VWF secretion from endothelial cells and possibly cause VWD type 1. Featured ArticlesA novel cause of type 1 von Willebrand disease: impaired exocytosis of Weibel-Palade bodies due to biallelic MADD variantsSophie Hordijk, Stijn A. Groten, Petra E. Bürgisser, Sebastiaan N. J. Laan, Georg Christoph Korenke, Tomáš Honzík, Diane Beysen, Frank W. G. Leebeek, Paul A. Skehel, Maartje van den Biggelaar, Tom Carter, Ruben BieringsSequential targeting in multiple myeloma: talquetamab, a GPRC5D bispecific antibody, as a bridge to BCMA CAR-T therapyBinod Dhakal, Othman S. Akhtar, David Fandrei, Alexandria Jensen, Rahul Banerjee, Darren Pan, Shambavi Richard, Reed Friend, Matthew Rees, Patrick Costello, Mariola Vazquez Martinez, Oren Pasvolsky, Charlotte Wagner, James A. Davis, Omar Castaneda Puglianini, Ran Reshef, Aimaz Afrough, Danai Dima, Manisha Bhutani, Omar Nadeem, Ricardo Parrondo, Ciara Freeman, Lekha Mikkilineni, Shahzad Raza, Larry D. Anderson Jr, Prashant Kapoor, Hitomi Hosoya, Saurabh Chhabra, Ariel Grajales-Cruz, Mahmoud Gaballa, Shonali Midha, Melissa Alsina, Douglas Sborov, Krina Patel, Yi Lin, Christopher Ferreri, Nico Gagelmann, Anupama Kumar, Doris Hansen, Andrew Cowan, Luciano J. Costa, Maximilian Merz, Surbhi Sidana

NEJM This Week — Audio Summaries
NEJM This Week — October 23, 2025

NEJM This Week — Audio Summaries

Play Episode Listen Later Oct 22, 2025 25:34


In this episode, we look at new research on mucoactive therapy for bronchiectasis, aspirin use in anticoagulated patients with coronary disease, and sotatercept for early pulmonary arterial hypertension. We explore the genetics behind misdiagnosed common diseases and review uncertainty in medical training. We also share a case of woman with abdominal distention, edema, and pleural effusions and Perspectives on sickle cell disease, fetal personhood, and living with a genetic diagnosis.

Health Check
How imposters distort medical research

Health Check

Play Episode Listen Later Oct 22, 2025 26:28


As Japan declares a flu epidemic we find out more about what's going on in the country, and the potential implications for the flu season ahead in the Northern Hemisphere.Human and bot imposters are rising in medical research, and they risk undermining results, but why do they do it? Eileen Morrow from the University of Oxford explains the tricky balance of safeguarding against them whilst not excluding real participants. A new adrenaline nasal spray has been licenced for those with severe allergies. Family Doctor Ayan Punja explains what a difference this might make for patients.The first patient has been recruited in a phase III trial investigating malaria treatments in early pregnancy. We speak to her and the researchers who are hoping to recruit further participants in Mali, Burkina Faso and Kenya.Plus, how far can you really push yourself? Researchers think they've found the ‘metabolic ceiling' for endurance athletes.Presenter: Claudia Hammond Producers: Katie Tomsett and Hannah Robins

Intelligent Medicine
Intelligent Medicine Radio for October 18, Part 2: Conquering Inflammation

Intelligent Medicine

Play Episode Listen Later Oct 20, 2025 44:18


Move Your Mind with Nick Bracks
#241: Casey Beros - Stop Waiting for the Perfect Time

Move Your Mind with Nick Bracks

Play Episode Listen Later Oct 20, 2025 58:37


When motivation disappears and perfectionism takes over, most people shut down. Casey Beros learned the opposite approach. We talk about how to stop waiting for the perfect time, why momentum matters more than motivation, and the small daily actions that can rebuild your health and mindset when you feel stuck.Timestamps: (00:00) Overcoming Perfectionism(00:32) Introduction(01:35) Casey's Journey(02:47) The Fascination with Health and Wellbeing(06:37) Navigating the Healthcare System(07:46) The Role of Influencers in Health Communication(09:58) Finding Credible Health Information(13:32) Casey's Book - Next of Kin(15:57) The Impact of Being a Carer(21:25) The Importance of Intergenerational Care(25:13) Challenges in the Healthcare System(29:55) The Need for Preventative Care(31:45) Preventative Approaches in Healthcare(32:04) The Slow Pace of Medical Research(32:52) The Impact of AI on Medicine(33:49) Innovative Mental Health Solutions in the UK(35:19) Caring for Carers - Mental and Physical Health Tips(38:38) The Importance of Social and Spiritual Wellbeing(42:17) Momentum Over Motivation(45:17) The Burden of Caregiving and Health Debt(49:13) Action Cures Inaction(50:29) Closing Thoughts and ReflectionsAccess FREE Move Your Mind training here:https://go.moveyourmind.io/trainingConnect with Nick:Instagram: https://instagram.com/nickbracksWebsite: http://nickbracks.comEmail: contact@nickbracks.com Hosted on Acast. See acast.com/privacy for more information.

B Heppy
Expanding Access to Hepatitis B Treatment: Breaking Barriers in Care

B Heppy

Play Episode Listen Later Oct 20, 2025 60:16


In this episode, Anousha is joined by Dr. Su Wang, Medical Director of the Chinese Medical Program at Cooperman Barnabas Medical Center and Medical Advisor to the Hepatitis B Foundation, along with Dr. Thomas Tu, Molecular Biologist at the Westmead Institute for Medical Research in Australia. Together, they discuss expanding hepatitis B treatment guidelines by broadening eligibility criteria, improving access, reducing loss to follow-up, and the importance of including public health and patient perspectives in guideline development. Read more about their new paper here: https://pubmed.ncbi.nlm.nih.gov/40714036/Support the showOur website: www.hepb.orgSupport B Heppy!Social Media: Instagram - Twitter - Facebook

Oxford+
Oxford North: The New Innovation District in Oxford

Oxford+

Play Episode Listen Later Oct 20, 2025 31:30 Transcription Available


How do you design a physical space that matches the lightning-fast pace of modern scientific discovery? This episode explores the new paradigm for innovation districts with Professor Dame Kay Davies and Victoria Collett of Thomas White Oxford, the development company of St. John's College. The conversation covers the critical transition from academic lab work, where Professor Davies has spent 30 years researching Duchenne Muscular Dystrophy, to the intense, milestone-driven world of biotech spin-outs. Victoria Collett, Development Director for the £1.2  billion Oxford North project, explains how its mixed-use, master-planned environment—complete with flexible lab spaces, public art, and community areas—is specifically engineered to foster the "serendipitous moments" crucial for breakthroughs. Kay and Victoria also discuss the vital importance of connectivity, noting that the UK's life sciences VC investment has been selective recently, making integrated innovation clusters like Oxford North, which is positioned on the East West Rail corridor, essential for capturing future talent and growth. (00:00) - Welcome to Oxford+ (01:10) - Kay Davies' Journey in Medical Research (02:10) - Challenges and Innovations in Drug Development (03:11) - The Role of Oxford North in Scientific Advancements (06:39) - Victoria Collett on Developing Oxford North (08:06) - Designing Spaces for Innovation and Collaboration (11:54) - Integrating Science, Art, and Community (18:56) - The Importance of Connectivity and Accessibility (26:26) - Long-Term Vision and Investment in Oxford North (30:10) - Historical Significance and Future Aspirations Professor Dame Kay Davies: An acclaimed academic and innovator, she is Emeritus Dr Lee's Professor of Anatomy at the University of Oxford and a Fellow of Hertford College. Her research group has an international reputation for work on Duchenne Muscular Dystrophy, an effort that has driven her journey from the academic lab to founding biotech spin-out companies to deliver effective treatments to patients. Her insights provide a critical 'user perspective' on the needs of a pioneering science ecosystem. Connect with Kay on LinkedInVictoria Collett: Development Director at Thomas White Oxford, the development company of St. John's College, where she led the creation of Oxford North. A chartered surveyor with over 20 years of experience in development and regeneration, Victoria specialises in large-scale mixed-use masterplans, bringing a unique perspective on community, placemaking, and commercial flexibility to the £1.2 billion global innovation district.Connect with Victoria on LinkedInSusannah de Jager: Susannah is a seasoned professional with over 15 years of experience in UK asset management. She has worked closely with industry experts, entrepreneurs, and government officials to shape the conversation around domestic scale-up capital.Connect with Susannah on LinkedIn / Subscribe to the Oxford+ Newsletter for exclusive contentOxford+ is hosted by Susannah de Jager and supported by Mishcon de Reya and Oxford North.Produced and edited by Story Ninety-Four in Oxford.

The Medical Journal of Australia
Episode 590: MJA Podcasts 2025 Episode 20 - Lung Cancer Screening Program

The Medical Journal of Australia

Play Episode Listen Later Oct 19, 2025 17:42


Australia has its first new cancer screening programme in 20 years, this time for lung cancer. Today we'll be discussing this new programme in depth as well as the role of primary care and the supports available in delivering the programme.This podcast is Sponsored by the Australian Government National Lung Cancer Screening Program.Professor Vivienne Milch is Medical Director, at Cancer Australia. Professor Milch is also Medical Advisor to the Australian Commonwealth Department of Health, Disability and Ageing on cancer screening policy.Professor Milch holds a Master's degree in Health Policy and is an Adjunct Clinical Associate Professor in the School of Medicine, Sydney Campus at The University of Notre Dame, Australia and Professorial Fellow at the Caring Futures Institute at Flinders University in Adelaide. Prior to joining Cancer Australia, Professor Milch was a General Practitioner and clinical researcher at the Garvan Institute of Medical Research, Sydney. Relevant links: the Investigating Symptoms of Lung Cancer guide Healthcare Provider Toolkit The NLCSP website Program Guidelines GP guide resource Reducing stigma in the program Low-dose CT Scan request form eLearning modules developed by Lung Foundation Australia Actionable additional findings guidelines

Blood Podcast
Spotlight on Acute Myeloid Leukemia

Blood Podcast

Play Episode Listen Later Oct 16, 2025 21:39


In this Spotlight series episode on Acute Myeloid Leukemia, Blood Editor, Dr. Selina Luger interviews Drs. Laura Michaelis and Alexander Perl on their paper in the series titled “The fit older adult with acute myeloid leukemia: clinical challenges to providing evidence-based frontline treatment”. The conversation explores challenges in treating AML across different patient populations. They also focus on treatment approaches for fit older adults with AML, highlighting the need for less toxic therapies and ongoing randomized trials to better understand treatment efficacy. See the full spotlight series on Acute Myeloid Leukemia in Volume 145 Issue 24 of Blood journal. 

NEJM This Week — Audio Summaries
NEJM This Week — October 16, 2025

NEJM This Week — Audio Summaries

Play Episode Listen Later Oct 15, 2025 30:33


In this episode, we look at new research in cervical cancer, lupus, gene therapy for immune deficiency, and malaria prevention in infants. We review hair loss in women, follow a case of tuberculosis in advanced HIV, and hear perspectives on vaccines, primary care, digital health, infection surveillance, AI in disaster response, Medicare policy, and bearing witness in conflict zones.

JHLT: The Podcast
Episode 71: Cardiogenic Shock Working Group: Patients on Impella 5.5 for more than 14 days

JHLT: The Podcast

Play Episode Listen Later Oct 15, 2025 21:09


On this episode of JHLT: The Podcast, the Digital Media Editors invite co-lead author Nir Uriel, MD, Director of Advanced Heart Failure and Cardiac Transplantation at New York Presbyterian Hospital and Professor of Medicine at Columbia University. Dr. Uriel joins to discuss the work of the Cardiogenic Shock Working Group (CSWG) and their recent paper, “Outcomes of patients supported on Impella 5.5 for more than 14 days: A Cardiogenic Shock Working Group registry analysis.” The discussion explores: Why patients on longer duration of MCS had better survival but maintained similar rates of serious adverse events (SAEs) Why the study might show fewer SAEs than the literature historically shows How temporary MCS devices are selected in clinical settings in patients with cardiogenic shock The ongoing and upcoming activities of CSWG For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt. Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

Blood Podcast
Busulfan-melphalan conditioning in newly diagnosed, transplant-eligible multiple myeloma; and use of spatial transcriptomics to probe the three-dimensional properties of multiple myeloma bone marrow microenvironments

Blood Podcast

Play Episode Listen Later Oct 14, 2025 13:13


In this week's episode we'll learn more about a study comparing busulfan-melphalan with melphalan alone as the conditioning protocol for newly diagnosed, transplant-eligible multiple myeloma; then we will discuss data on how three-dimensional transcriptomics can reveal complex interactions between plasma cells and bone marrow microenvironments.Featured ArticlesHigh-dose busulfan-melphalan vs melphalan and reinforced VRD for newly diagnosed multiple myeloma: a phase 3 GEM trialProfiling the spatial architecture of multiple myeloma in human bone marrow trephine biopsy specimens with spatial transcriptomicsPreclinical advances in glofitamab combinations: a new frontier for non-Hodgkin lymphoma

NEJM This Week — Audio Summaries
NEJM This Week — October 9, 2025

NEJM This Week — Audio Summaries

Play Episode Listen Later Oct 8, 2025 22:04


In this episode, we explore new treatments for hypertension, hereditary amyloidosis, and malaria prevention, along with insights on mosquito-borne disease control. We review idiopathic intracranial hypertension, follow a striking case of a hidden foreign body, and hear perspectives on worker safety, immigrant health care, the role of pharmaceutical wholesalers, and the arc of a medical career.

#IMOMSOHARD
HUNTINGTON'S DISEASE BREAKTHROUGH, FARM ROOTS, & BREAST CANCER AWARENESS

#IMOMSOHARD

Play Episode Listen Later Oct 7, 2025 40:16


Ladies, it's Breast Cancer Awareness Month, so go get your boobies checked! We're also talking family lineage, growing up on a farm, and the groundbreaking treatment for Huntington's disease.00:00:00 - Introduction & Getting Started 00:02:04 - Fall Season & Halloween Decorations Debate 00:05:27 - Big Tea & Do Dog (Parent Nicknames) 00:15:27 - Big Family Reflections 00:20:08 - Family Genealogy & Lineage00:24:11 - Pop Culture & Science Discussion00:30:16 - Gene Therapy & Medical Research 00:33:07 - Eric Dane & ALS Awareness 00:37:11 - mRNA Vaccine Technology 00:38:36 - Wrapping Up & Superpower TalkMORE PODCAST EPISODES: https://youtube.com/playlist?list=PLTGuNbPgq2EartAwwgs_H-LVho3FvWnXpJUST LISTEN TO THE PODCAST: https://link.chtbl.com/imomsohardSEE US ON TOUR: (FALL DATES COMING SOON)https://www.imomsohard.com/WATCH OUR AMAZON PRIME SPECIAL: https://www.amazon.com/IMomSoHard-Live/dp/B07VBJ34DTIf you are interested in advertising on this podcast email ussales@acast.comTo request #IMOMSOHARD to be on your Podcast, Radio Show, or TV Show, reach out to talent@pionairepodcasting.comFOLLOW US: Facebook: https://www.facebook.com/imomsohardInstagram: https://www.instagram.com/imomsohard/Twitter: https://twitter.com/imomsohardGet our sponsor DISCOUNT CODES here!https://linktr.ee/imshpodcastABOUT US Female comedy duo Kristin Hensley and Jen Smedley have been performing, teaching, and writing comedy internationally for a combined 40+ years. They have been moms for one quarter of that time and it shows. How do they cope? They laugh about all of the craziness that comes with being a mom and they want you to laugh about it too! From snot to stretchmarks to sleepless nights, Kristin and Jen know firsthand that parenting is a hard job and they invite you to join them in taking it all a little less seriously (even if for a few short minutes a day). After all, Jen currently has four days of dry shampoo in her hair and Kristin's keys are still in her front door. They try, they fail, they support each other, and they mom as hard as they can.Disclaimer: This podcast is for entertainment purposes only. Views expressed on this podcast solely reflect those of the host and do not reflect the views of Pionaire. Hosted on Acast. See acast.com/privacy for more information.

Today in Focus
My dad, his ‘incurable' disease, and hope at last

Today in Focus

Play Episode Listen Later Oct 6, 2025 29:03


The Guardian journalist Josh Halliday talks about Huntington's disease, the impact the rare inherited condition has had on his family and the hope there may now be a treatment. Help support our independent journalism at theguardian.com/infocus

Autoimmune Rehab: Autoimmune Healing, Support for Autoimmune Disorders, Autoimmune Pain Relief
Wiring Down the Fire: Dr. Kevin Tracey on Inflammation, Arthritis, and the Vagus Nerve: Inflammation Arthritis

Autoimmune Rehab: Autoimmune Healing, Support for Autoimmune Disorders, Autoimmune Pain Relief

Play Episode Listen Later Oct 3, 2025 32:25


In this expert interview, I sit down with Dr. Kevin Tracey—pioneer of the “inflammatory reflex” and a leading voice on neuroimmune science—to unpack how your nervous system can dial inflammation up or down. We explore what's really driving inflammatory arthritis, why the vagus nerve is a key switch for immune balance, and how neuromodulation (yes, stimulating nerves!) is opening new, drug-sparing frontiers for pain and flare control. You'll learn the difference between protective vs. destructive inflammation, practical ways to support vagal tone, and what the latest research means for people living with autoimmune and inflammatory conditions. If you've wondered how the brain, immune system, and joints talk to each other, this conversation connects the dots—and offers hope. Kevin J. Tracey, MD, is president and CEO of the Feinstein Institutes for Medical Research at Northwell Health, a pioneer of vagus nerve research and author of The Great Nerve. A leader in the scientific fields of inflammation and neuroscience, his lab studies vagus nerve stimulation and bioelectronic medicine. His contributions include first identifying the therapeutic action of monoclonal anti-TNF antibodies and discovering the specific reflex control of immunity by the nervous system, called the “inflammatory reflex.” These discoveries launched the new scientific field called bioelectronic medicine, which investigates the therapeutic applications of vagus nerve stimulation to cure disease. Dr. Tracey, a neurosurgeon, pursued studies of inflammation after the mysterious death of a toddler from sepsis who was in his care. His lab has since revealed molecular mechanisms of inflammation and identified the use of vagus nerve stimulation to treat it. An inventor on more than 120 U.S. patents and the author of more than 450 scientific publications, he is among the most highly cited scientists in the world. He co-founded the Global Sepsis Alliance, is the author of Fatal Sequence (Dana Press) and is a national and international lecturer. Check out Dr. Tracey's Ted Talk here:https://www.youtube.com/watch?v=AJH9KsMKi5M Free consultation with me and check out my memership with essential oils program: http://essentialwellnesscircle.com Follow me on instagram: https://instagram.com/annalaurabrownwellness Youtube channel with videos of this podcast and more: https://youtube.com/c/annalaurabrownhealthcoach    

Science Weekly
Fraud, AI slop and huge profits: is science publishing broken?

Science Weekly

Play Episode Listen Later Oct 2, 2025 18:13


Scientists are warning that academic publishing needs urgent reform in order to retain trust in the research system. Ian Sample tells Madeleine Finlay what has gone so wrong, and Dr Mark Hanson of the University of Exeter proposes some potential solutions. Help support our independent journalism at theguardian.com/sciencepod

Nightside With Dan Rea
Medical Research Uncertainty

Nightside With Dan Rea

Play Episode Listen Later Oct 2, 2025 37:59 Transcription Available


Due to President Trump's sweeping federal cuts to medical research, many colleges and universities are faced with financial uncertainty. Why does the government want to make cuts to medical/science research? How worried are you about delays in potentially lifesaving research? UMass Chan Medical School Chancellor Dr. Michael F. Collins joined us on NightSide to discuss.

Blood Podcast
Use of Marstacimab for Prophylaxis in hemophilia A and B; matched-donor allogeneic CD19 CAR-T in adult B-ALL; a new prognostic index for T-cell cutaneous lymphomas

Blood Podcast

Play Episode Listen Later Oct 2, 2025 19:43


In this week's episode we'll learn about targeting the tissue factor pathway inhibitor with a monoclonal antibody to rebalance HEMOSTASIS in hemophilia A and B. In the phase 3 BASIS trial, the monoclonal antibody marstacimab reduced bleeding events, and was generally well tolerated, with no unanticipated side effects. After that: matched-donor allogeneic CD19 CAR-T for adult B-ALL. Given after allogeneic transplantation, CAR-donor lymphocyte infusion after lymphodepleting chemotherapy was associated with favorable efficacy and a tolerable safety profile. Finally: a new prognostic index for mycosis fungoides and Sézary syndrome. Comprised of four prognostic factors, the “CLIPI” could enable more personalized treatment of cutaneous lymphomas, identifying patients who may benefit from intensified treatment.Featured ArticlesMarstacimab prophylaxis in hemophilia A/B without inhibitors: results from the phase 3 BASIS trialMatched donor allogeneic CAR-T for adult B-ALL: toxicity, efficacy, repeat dosing, and the importance of lymphodepletionA new prognostic index (CLIPI) for advanced cutaneous lymphoma enables precise patient risk stratification

Blood Podcast
How I Treat Wiskott-Alrich syndrome

Blood Podcast

Play Episode Listen Later Oct 2, 2025 13:16


In this How I Treat podcast episode, Laura Michaelis, MD interviews Sung-Yun Pai, MD about their recently published article in Blood journal "How I treat Wiskott-Alrich syndrome". They highlight recent updates in treatment, including new risk-benefit calculations due to safer treatments and longer follow-ups. Challenges include late diagnosis, lack of well-matched donors, and limited gene therapy availability. They emphasize the importance of early referral to specialized centers and the need for discussions about curative intent therapies, including transplant and gene therapy. The conversation also covers the complexities of gene therapy, such as the need for better conditioning agents and the challenges of achieving full correction in all cell types.

NEJM This Week — Audio Summaries
NEJM This Week — October 2, 2025

NEJM This Week — Audio Summaries

Play Episode Listen Later Oct 1, 2025 21:59


Featuring articles on severe acute malnutrition with gastroenteritis in children, medical imaging and pediatric cancer risk, moderate hypertriglyceridemia, preventing RSV disease in healthy infants, and treating hypertension in rural South Africa; a review article on monoclonal gammopathy of undetermined significance; a Clinical Problem-Solving on a shifting frame; and Perspectives on insight into corporate governance, on pharmaceutical tariffs, and on OUD medications.

JHLT: The Podcast
Episode 70: Passive Leg Raise and Occult HFpEF in Pulmonary Hypertension

JHLT: The Podcast

Play Episode Listen Later Oct 1, 2025 15:37


On this episode of JHLT: The Podcast, the Digital Media Editors invite author Dr. Ayumi Goda, from the Kyorin University Hospital in Tokyo, Japan, to discuss her team's paper, “Prevalence of occult HFpEF and age-specific efficacy of passive leg raise in pulmonary hypertension.” The discussion explores: How clinical observations led to the idea for a study on whether the passive leg raise could unmask occult HFpEF The potential diagnostic value of the passive leg raise in differing patient populations Age-specific cutoffs that may influence what kind of testing to use in clinical practice For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt. Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

Super Woman Wellness by Dr. Taz
How Birth Control Changes Your Brain, Mood & Relationships with Dr. Sarah E. Hill

Super Woman Wellness by Dr. Taz

Play Episode Listen Later Sep 30, 2025 62:26


Subscribe to the video podcast: https://www.youtube.com/@DrTazMD/podcastsWhat if the birth control you're taking every day is quietly changing your brain, your mood, your relationships—and even who you're attracted to? In this groundbreaking episode of hol+, Dr. Taz MD sits down with award-winning researcher and author Dr. Sarah Hill (This Is Your Brain on Birth Control) to reveal the shocking, little-known science of how hormonal contraception shapes not just your reproductive system, but your entire mind and body.From altered stress responses to shifts in attraction, depression risk in teens, and the controversial “bikini science” problem in medical research, Dr. Hill pulls back the curtain on decades of overlooked studies that every woman and parent should know about. She shares her own journey from evolutionary psychologist to outspoken women's health advocate, explaining why synthetic progestins are not the same as progesterone, how birth control affects your immune system, and why teenagers may be especially vulnerable to its mental health effects.If you're a woman in your teens, 20s, 30s, or 40s—or a parent guiding your daughter—this episode could change the way you think about hormone health, fertility, and your body's natural rhythms.Dr. Hill and Dr. Taz discuss:How birth control changes the brain's structure and functionThe difference between progesterone and synthetic progestins (and why it matters)Why “bikini science” has failed women in medical researchThe surprising link between birth control and partner attractionThe immune system's hidden connection to hormonal cyclingTeen mental health risks: depression, anxiety, and brain developmentSafer contraceptive choices and how to support your body if you use the pillHow nutrition and micronized progesterone might help offset side effectsThis conversation is more than just information — it's a wake-up call for how we study, prescribe, and support women's health.Topics Covered:Hormonal birth control's impact on the brainSynthetic hormones vs. bioidentical hormonesPartner choice and relationship satisfaction researchAutoimmunity and immune system differences in womenMental health risks for adolescent usersNon-hormonal birth control optionsNutritional and hormonal support strategiesConnect further to Hol+ at https://holplus.co/- Don't forget to like, subscribe, and hit the notification bell to stay updated on future episodes of hol+.About Dr. Sarah E. HillSarah E. Hill, Ph.D., is the author of This is Your Brain on Birth Control and an award-winning researcher who has spent most of her 20+ year career studying women, relationships, and health. In addition to having established an award-winning health and relationships lab at TCU, she has published nearly 100 academic research articles, is a sought-after public speaker, and sits on the scientific advisory boards for women's health companies such as Flo and 28 Wellness. Her research is regularly covered by national media, such as The Washington Post, The New York Times, and many others, and is regularly published in highly prestigious journals, including Journal of Personality and Social Psychology, Psychoneuroendocrinology, Psychological Science, and Health Psychology.Stay ConnectedSubscribe to the audio podcast: https://holplus.transistor.fm/subscribeSubscribe to the video podcast: https://www.youtube.com/@DrTazMD/podcastsFollow Dr. Taz on Instagram: https://www.instagram.com/drtazmd/https://www.instagram.com/liveholplus/Join the conversation on X: https://x.com/@drtazmdTikTok: https://www.tiktok.com/@drtazmdFacebook: https://www.facebook.com/drtazmd/Connect with Dr. Sarah E. Hill:https://www.sarahehill.com/https://www.instagram.com/sarahehillphdHost & Production TeamHost: Dr. Taz; Produced by Rainbow Creative (Executive Producer: Matthew Jones; Lead Producer: Lauren Feighan; Editors: Jeremiah Schultz and Patrick Edwards)Don't forget to like, subscribe, and hit the notification bell to stay updated on future episodes of hol+Chapters00:00 Introduction06:12 The Flaws in Medical Research on Women17:51 Dr. Hill's Personal Journey with Birth Control21:43 The Science Behind Birth Control's Effects on the Brain27:45 How Birth Control Influences Attraction and Relationships34:44 Impact of Birth Control on Relationship Satisfaction37:31 Divorce Rates and Birth Control40:12 Hormones and Brain Influence41:35 Hormone Replacement Therapy (HRT): Progesterone vs. Progestin47:57 Birth Control and Mental Health in Teens01:00:16 Conclusion and Final Thoughts

Intelligent Medicine
Lyme Disease Exposed: Breaking Down Misdiagnoses and Innovations, Part 1

Intelligent Medicine

Play Episode Listen Later Sep 30, 2025 33:47


This episode of the Intelligent Medicine podcast is a deep dive into the complexities of Lyme disease and other tick-borne illnesses. Nicole Bell, the CEO of Galaxy Diagnostics and author of “What Lurks in the Woods,” details the challenges of diagnosing tick-borne diseases, the limitations of current diagnostic tests, and the controversy around treatment methodologies. Nicole shares her personal journey that led her to this field after her husband was misdiagnosed with early-onset Alzheimer's, which was later revealed to be caused by advanced Lyme disease. They also discuss new diagnostic techniques, the importance of personalized treatment plans, and ongoing advocacy efforts to improve awareness and research funding for Lyme disease.

Full Story
Paracetamol and Donald Trump's medical myths

Full Story

Play Episode Listen Later Sep 28, 2025 20:26


When the US president stood up at the podium and announced a link between autism and paracetamol, he sent alarm through the medical community and the public. Guardian science correspondent Hannah Devlin speaks to Reged Ahmad about what the science actually says about the painkiller and why experts fear Donald Trump is deliberately fostering a narrative of distrust

The Space Show
John Batchelor Hotel Mars features Ben Roberts on microgravity medical research, medical products, private sector investment and the ISS National Lab

The Space Show

Play Episode Listen Later Sep 27, 2025 19:21


Hotel Mars with Ben Roberts for Sept. 24, 2025Summary by Zoom. Edited.This Hotel Mars program featured a discussion microgravity investor Ben Roberts about the applications and investments in microgravity technology, including its impact on medical treatments, drug formulations, and material sciences. We explored the progress and challenges of commercial space companies in microgravity research and production, with NASA's support programs playing a crucial role in their development. The conversation covered various applications of low microgravity, the competitive landscape of the industry, and the timeline for product development and market entry.John Batchelor welcomed Ben Roberts, an investor in microgravity, to discuss the applications and investments in microgravity technology. Ben explained that microgravity refers to the limited effect of gravity in orbit, which enables innovative applications in medical treatments, drug formulations, and material sciences. He highlighted examples such as creating artificial limbs, developing new drugs, and producing high-quality materials that are not possible on Earth due to gravity's interference. Ben clarified that microgravity applies to any orbit with low enough gravity to affect living systems and material defects, but not enough to eliminate sedimentation or convection.Ben discussed the progress and challenges of commercial space companies, particularly those involved in microgravity research and production. While basic research on space shuttles and the ISS has been ongoing for decades, commercial companies like Varda and Redwire are just beginning to reach commercialization, producing medical seed crystals and elements. He noted that NASA's support through programs like SBIR has been crucial in helping these companies transition from pre-commercial to operational phases. The discussion also touched on the financial challenges these companies face, suggesting that private sector or government investment might be needed to bridge the gap until traditional VCs become involved once commercial viability is proven.Ben continued to discuss various applications of low microgravity, including advanced nanoparticles for drug delivery, accelerated aging studies, and 3D printed cardiac tissue. He explained how these technologies could be more effective when produced in space, despite higher costs. The panelists agreed that while some products could reach the market in 2-5 years, those requiring FDA approval might take longer, with significant progress expected by the 2030s.Special thanks to our sponsors:Northrup Grumman, American Institute of Aeronautics and Astronautics, Helix Space in Luxembourg, Celestis Memorial Spaceflights, Astrox Corporation, Dr. Haym Benaroya of Rutgers University, The Space Settlement Progress Blog by John Jossy, The Atlantis Project, and Artless EntertainmentOur Toll Free Line for Live Broadcasts: 1-866-687-7223For real time program participation, email Dr. Space at: drspace@thespaceshow.comThe Space Show is a non-profit 501C3 through its parent, One Giant Leap Foundation, Inc. To donate via Pay Pal, use:To donate with Zelle, use the email address: david@onegiantleapfoundation.org.If you prefer donating with a check, please make the check payable to One Giant Leap Foundation and mail to:One Giant Leap Foundation, 11035 Lavender Hill Drive Ste. 160-306 Las Vegas, NV 89135Upcoming Programs: Get full access to The Space Show-One Giant Leap Foundation at doctorspace.substack.com/subscribe

Politics Weekly America
Why is the Trump administration obsessed with autism?

Politics Weekly America

Play Episode Listen Later Sep 26, 2025 28:21


The US health secretary, Robert F Kennedy Jr, has long been consumed by the neurological condition autism – what causes it, and whether there's a treatment. This week, Donald Trump took on the cause, making claims about acetaminophen, also known as Tylenol and paracetamol, that were dismissed outright by medical experts around the world. Jonathan Freedland speaks to Carter Sherman, the reproductive health and justice reporter at Guardian US, about when and why the obsession with autism became political

Blood Podcast
Epstein-Barr virus genomic variants in human disease states, somatic GATA1 mutations and leukemia in Down syndrome, and new definitions for high-risk multiple myeloma

Blood Podcast

Play Episode Listen Later Sep 25, 2025 18:01


In this week's episode, we'll learn more about relationships between Epstein-Barr virus genomic variants and human diseases, including hematological malignancies; the presence and timing of somatic GATA1 mutations and their relationship to a Down syndrome-specific form of leukemia; and new definitions for high-risk multiple myeloma that emphasize the presence of two or more high-risk cytogenetic abnormalities.Featured Articles:Association of Epstein-Barr virus genomic alterations with human pathologiesClinical significance of preleukemic somatic GATA1 mutations in children with Down syndromeBiallelic antigen escape is a mechanism of resistance to anti-CD38 antibodies in multiple myeloma

NEJM This Week — Audio Summaries
NEJM This Week — September 25, 2025

NEJM This Week — Audio Summaries

Play Episode Listen Later Sep 24, 2025 24:04


Featuring articles on heart failure, provoked venous thromboembolism, chronic lymphocytic leukemia, and acute ischemic stroke; a review article on medical education to improve diagnostic equity; a case report of a man with embolic stroke and left ventricular apical aneurysm; two articles on the 2025 Lasker–DeBakey Clinical Medical Research Award; and Perspectives on structural and scientific racism, on the Gates Foundation's final chapter, and on Dr. Kolhouse and the cowboy.

20-Minute Health Talk
Not your father's prostate cancer: How screening, biopsy and treatment is changing for the better

20-Minute Health Talk

Play Episode Listen Later Sep 24, 2025 20:28


Prostate cancer deaths have been climbing over the last decade in part due to confusion over who should be screened and treated. In part 1 of a three-part series on prostate cancer, host Sandra Lindsay speaks with Samir Taneja, MD, a trailblazer in urologic cancer innovation, to explore how modern diagnostics and treatments, such as the groundbreaking use of MRI technology, are transforming patient outcomes. As Northwell's senior vice president and system chair of urology, Dr. Taneja provides invaluable insights into the shifting landscape of prostate cancer care and the critical importance of early detection. Tune in to understand the vital steps needed to increase awareness and save lives. About Northwell Health Northwell Health is New York State's largest healthcare provider and private employer, with 21 hospitals, 850 outpatient facilities and more than 16,600 affiliated physicians. We're making breakthroughs in medicine at the Feinstein Institutes for Medical Research. We're training the next generation of medical professionals at the visionary Donald and Barbara Zucker School of Medicine at Hofstra/Northwell and the Hofstra Northwell School of Nursing and Physician Assistant Studies. For information on our more than 100 medical specialties, visit Northwell.edu and follow us @NorthwellHealth on Facebook, Instagram, X and LinkedIn. Get the latest news and insights from our experts in the Northwell Newsroom: Press releases Insights Podcasts Publications Interested in a career at Northwell Health? Visit http://bit.ly/2Z7iHFL and explore our many opportunities. Get more expert insights from leading experts in the field — Northwell Newsroom.  Watch episodes of 20-Minute Health Talk on YouTube.  For information on our more than 100 medical specialties, visit Northwell.edu and follow us @NorthwellHealth on Facebook, Instagram, X and LinkedIn. Interested in a career at Northwell Health? Visit the health system's job portal and explore our many opportunities.    

Science Weekly
Is there hope on the horizon for patients with Alzheimer's?

Science Weekly

Play Episode Listen Later Sep 23, 2025 14:52


A trial is under way to find out if a £100 blood test could transform the way that the NHS diagnoses Alzheimer's disease. Alzheimer's is the leading cause of dementia and diagnosis is currently costly and time-consuming. To find out how this blood test could benefit patients, Ian Sample talks to Prof Jonathan Schott, who is co-leading the trial. He explains what the test involves and why it could pave the way for exciting new treatments for the devastating disease. Help support our independent journalism at theguardian.com/sciencepod

Blood Podcast
Azacitidine holds promise in VEXAS syndrome; a step forward in precision blood matching; identifying a new vulnerability in TP53-mutated AML

Blood Podcast

Play Episode Listen Later Sep 18, 2025 18:58


In this week's episode we'll learn about Azacitidine in VEXAS syndrome. Treatment can provide responses in patients with this complex autoinflammatory disorder. But relapse rates were high, so long-term therapy may be required to maintain disease control. After that: A step forward in precision blood matching. High-throughput array genotyping enables extended matching to reduce antibody formation. The results show the potential for reducing harm in regularly transfused patients. Finally, identifying a new vulnerability in TP53-mutated AML. Loss of the tumor suppressor BAP1 defines a unique subtype of TP53-mutated de novo AML. BAP1 loss also confers sensitivity to BCL-xL inhibitors in vivo, opening a new therapeutic avenue.Featured ArticlesEfficacy and safety of azacitidine for VEXAS syndrome: a large-scale retrospective study from FRENVEXArray genotyping of transfusion-relevant blood cell antigens in 6946 ancestrally diverse study participantsLoss of BAP1 defines a unique subtype of TP53-mutated de novo AML and confers sensitivity to BCL-xL inhibitors

Blood Podcast
Review Series on Acute Lymphoblastic Leukemia (ALL)

Blood Podcast

Play Episode Listen Later Sep 18, 2025 12:38


In this Review Series episode, Associate Editor Dr. Hervé Dombret speaks with Dr. Mark Litzow about the latest immunotherapy advances for Acute Lymphoblastic Leukemia (ALL). The discussion highlights innovative treatments like blinatumomab and inotuzumab, which are showing remarkable success in clinical trials, including an 85% three-year survival rate and over 90% complete remission in elderly patients. Researchers are focusing on reducing chemotherapy intensity, developing personalized treatment approaches, and identifying optimal immunotherapy strategies for different ALL subtypes. The conversation underscores a promising shift towards more targeted, less toxic treatments that could significantly improve patient outcomes across various age groups and disease characteristics. These emerging therapies represent a potential paradigm shift in ALL treatment, offering hope for more effective and less aggressive therapeutic interventions.Read Dr. Litzow's paper “Incorporation of immunotherapy into frontline treatment for adults with B-cell precursor acute lymphoblastic leukemia” or find the whole review series on acute lymphoblastic leukemia in volume 145 issue 14 of Blood Journal. 

NEJM This Week — Audio Summaries
NEJM This Week — September 18, 2025

NEJM This Week — Audio Summaries

Play Episode Listen Later Sep 17, 2025 22:12


Featuring articles on PI3K-altered colorectal cancer, type 2 diabetes, oral semaglutide, and proportional-assist ventilation; a review article on tumor lysis syndrome; a case report of a girl with chest pain and bone and liver lesions; and Perspectives on integrating pharmacotherapy into tobacco control, on Medicaid enrollees with chronic conditions, and on ultraprocessed food.

GRUFFtalk How to Age Better with Barbara Hannah Grufferman
The Vagus Nerve Breakthrough: Fighting Inflammation Without Drugs — with Dr. Kevin J. Tracey (Part 1 of 2) EP 168

GRUFFtalk How to Age Better with Barbara Hannah Grufferman

Play Episode Listen Later Sep 16, 2025 40:34


“Someday, devices that stimulate the vagus nerve may replace many of the drugs people take for chronic disease.”— Dr. Kevin Tracey  Key Resources & Links  Dr. Kevin J. Tracey's new book: The Great Nerve  Dr. Kevin J. Tracey's TedTalk: Watch Here  Center for Bioelectronic Medicine: Official Site  SetPoint Medical: Official Site  Clinical Trials: clinicaltrials.gov  Follow me on Instagram for updates and giveaways: @BarbaraHannahGrufferman  Why Listen to This Episode?  In this first of a two-part series, I sit down with Dr. Kevin J. Tracey, neurosurgeon, CEO of the Feinstein Institutes for Medical Research, and founder of the field of bioelectronic medicine. He's also one of the most widely cited medical experts in the world. Together, we explore the science behind the vagus nerve, a vast communication highway between your brain and body that is proving to be a powerful regulator of inflammation.  Just weeks ago, the FDA approved the first implantable vagus nerve device for rheumatoid arthritis, a breakthrough that could pave the way for treating other conditions without drugs. Dr. Tracey explains what this milestone means, how the device works, and why it could someday replace some of the medications people rely on for chronic disease management.  What You'll Learn in Part 1  What the vagus nerve is, where it's located, and why it matters.  How inflammation drives diseases like heart disease, Alzheimer's, arthritis, and more.  The story behind the FDA-approved device that may change how we treat rheumatoid arthritis.  Why bioelectronic medicine could represent a seismic shift in healthcare.  ENTER TO WIN A COPY OF ‘THE GREAT NERVE'! How to enter: listen to the episode, share the link on Instagram and tag me @BarbaraHannahGrufferman⁠ . You'll be automatically entered to win a copy of this seminal book.   If you're enjoying Age Better, I'd be so grateful if you left a quick review wherever you listen.      And if there's a topic or question you'd love for me to cover in a future episode, send a note to agebetterpodcast@gmail.com -- I love hearing from you!    Learn more about your ad choices. Visit megaphone.fm/adchoices

The Incubator
#352 -

The Incubator

Play Episode Listen Later Sep 14, 2025 87:21


Send us a textIn this week's Journal Club, Ben and Daphna review several recent neonatal studies with direct implications for practice.They begin with the BORN trial from Italy, which investigated whether transfusing preterm infants with cord blood–derived red blood cells, rather than adult donor blood, could reduce severe retinopathy of prematurity (ROP). While the intention-to-treat analysis showed no difference, per-protocol findings suggest potential benefits that warrant larger trials.Next, they review a large international cohort study of outcomes in infants born at 22–23 weeks, highlighting striking variability in survival and morbidity across networks, with Japan showing the highest survival rates.The EBNeo segment features Dr. Gabriel Altit discussing an Indian randomized trial comparing norepinephrine vs. dopamine as first-line therapy for neonatal septic shock. Although primary outcomes were similar, norepinephrine showed some favorable metabolic and perfusion markers.The hosts then cover a delivery room resuscitation study identifying expiratory tidal volumes of 4–5 ml/kg as key for successful lung aeration, a Canadian trial of atropine for neonatal intubation, and a retrospective study from Alabama on optimal timing and frequency of pulmonary hypertension screening in BPD.The episode concludes with a case report on the use of continuous glucose monitoring in a neonate with congenital hyperinsulinism.Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

Blood Podcast
Diffuse large B-cell lymphoma's long-term effects on immune profiles, plasminogen activation and prevention of venous thromboembolism, and PARP inhibitors in hematological malignancies carrying epigenetic mutations

Blood Podcast

Play Episode Listen Later Sep 11, 2025 18:31


In this week's episode we'll learn about persistent changes in immune profiles in patients who have had diffuse large B-cell lymphoma, or DLBCL, and other cancers; that plasminogen activation and plasmin activity do not appear to play a role in routine physiological prevention of venous thromboembolism, or VTE; and about a novel mechanism that makes hematological malignancies carrying epigenetic mutations susceptible to PARP inhibitors.Featured Articles:Large B-cell lymphoma imprints a dysfunctional immune phenotype that persists years after treatmentPlasminogen activation and plasmin activity are not required to prevent venous thrombosis/thromboembolismTransposable elements as novel therapeutic targets for PARPi-induced synthetic lethality in PcG-mutated blood cancer

NEJM This Week — Audio Summaries
NEJM This Week — September 11, 2025

NEJM This Week — Audio Summaries

Play Episode Listen Later Sep 10, 2025 23:06


Featuring articles on hypertrophic cardiomyopathy, rehabilitation after myocardial infarction in older adults, the 2024 Marburg virus disease outbreak in Rwanda, and medications for opioid use disorder in county jails; a case report of a woman with dyspnea and fatigue; a Medicine and Society on the race-correction debates; and Perspectives on recent efforts toward equity, on medical research funding in a divided America, and on the end of days.

Blood Podcast
“Ironing out” Tet2-mutant HSPCs; A CAR-T “license to kill” in T cell leukemia/lymphoma; insights on cHL genetics, through the lens of ctDNA

Blood Podcast

Play Episode Listen Later Sep 4, 2025 20:43


In this week's episode, we'll learn about how TET2 is often mutated in myeloid malignancies and clonal hematopoiesis. In new work, expansion of Tet2-mutant HSPCs was dependent on Ncoa4, the cargo receptor mediating ferritinophagy. We'll iron out the implications. After that: a double-oh-seven license to kill in T-cell leukemia/lymphoma. WU-CART-007 is an off-the-shelf CAR T product with manageable safety and encouraging efficacy. With further work, it could become a new option for patients in urgent need of therapy. Finally: a comprehensive genetic study of classical Hodgkin lymphoma using circulating tumor DNA. This new research provides novel and complex insights on genetic subtypes, prognostic biomarkers, neoantigens in the disease environment, and more.Featured Articles:An in vivo barcoded CRISPR-Cas9 screen identifies Ncoa4-mediated ferritinophagy as a dependence in Tet2-deficient hematopoiesisPhase 1/2 trial of anti-CD7 allogeneic WU-CART-007 for patients with relapsed/refractory T-cell malignanciesA comprehensive genetic study of classic Hodgkin lymphoma using circulating tumor DNA

NEJM This Week — Audio Summaries
NEJM This Week — September 4, 2025

NEJM This Week — Audio Summaries

Play Episode Listen Later Sep 3, 2025 24:01


Featuring articles on obesity, type 1 diabetes, syphilis, and heparin-induced thrombocytopenia; a review article on the management of acute type B aortic dissection; a Clinical Problem-Solving describing a fruitful workup; and Perspectives on the corporatization deal, on advancing physician-scientist training in China, and on the rise of drug innovation in China.

JHLT: The Podcast
Episode 69: Optimal Pre-Transplant Duration with HeartMate III LVADs

JHLT: The Podcast

Play Episode Listen Later Sep 3, 2025 15:55


On this episode of JHLT: The Podcast, the Digital Media Editors invite first author Ahmet Bilgili, from the University of Florida's Congenital Heart Center, and senior author Eric I. Jeng, MD, from the University of Florida's MCS program. Bilgili and Dr. Jeng discuss their paper, “Optimal pretransplant duration with HeartMate III left ventricular assist device: A contemporary analysis.” The discussion explores: Prior gaps in the literature regarding contemporary HM3 outcomes in relation to transplantation—and the study's potential influence on policy Which length of HM3 support influenced better post-transplant outcomes—and which ages were most influenced How these findings might change standard practice For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt. Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.  

The Crossover with Dr. Rick Komotar
Dr. Kevin Tracey: The Great Nerve

The Crossover with Dr. Rick Komotar

Play Episode Listen Later Sep 2, 2025 38:32


Kevin J. Tracey is president and CEO and the Karches Family Distinguished Chair in Medical Research at the Feinstein Institutes for Medical Research; professor of Molecular Medicine and Neurosurgery at the Donald and Barbara Zucker School of Medicine at Hofstra/Northwell; and Executive Vice President, Research, at Northwell Health. A leader in the scientific fields of inflammation and bioelectronic medicine, his contributions include discovery and molecular mapping of neural circuits controlling immunity. Dr. Tracey received his BS in chemistry, summa cum laude, Phi Beta Kappa, from Boston College in 1979, and his MD from Boston University in 1983. He trained in neurosurgery from 1983 to 1992 at the New York Hospital-Cornell University Medical Center and was a guest investigator at the Rockefeller University before moving in 1992 to the Feinstein Institutes. There he directs the Laboratory of Biomedical Science and was appointed president and CEO in 2005.An inventor of more than 120 United States patents and author of more than 400 scientific publications, he cofounded the Global Sepsis Alliance, a non-profit organization supporting the efforts of more than 1 million sepsis caregivers in over 70 countries. Dr. Tracey is the author of Fatal Sequence (Dana Press) and delivers lectures nationally and internationally on inflammation, sepsis, the neuroscience of immunity, and bioelectronic medicine.

Transparently Speaking
Dr. Dad on Medical Research, Protecting Transgender Kids, and the Sports Debate (104)

Transparently Speaking

Play Episode Listen Later Sep 1, 2025 34:27


A physician dad shares how politics are disrupting research, parenting transgender kids, and the sports debate.In this episode, Diana sits down with her husband, Arthur, a physician researcher and parent, to talk about how today's shifting policies and headlines affect real families. Together, they cover three big themes:The ripple effects of political decisions on medical research and patient careWhat it means for parents of transgender kids to prepare and protect their familiesThe science, myths, and realities behind the transgender sports debateThis candid conversation sheds light on how systemic changes impact everyday lives, and what families and allies can keep in mind moving forward.If you're taking something away from our podcast, we'd appreciate it if you'd take a moment to provide us with a review; the more listeners and reviews, the more people we can reach and support. As always, feel free to reach out to us at transparentlyspeakingpodcast@gmail.com.

The Tim Ferriss Show
#824: Dr. Kevin Tracey — Stimulating The Vagus Nerve to Tame Inflammation, Alleviate Depression, Treat Autoimmune Disorders (e.g., Rheumatoid Arthritis), and Much More

The Tim Ferriss Show

Play Episode Listen Later Aug 26, 2025 143:18


Kevin J. Tracey, MD is president and CEO of the Feinstein Institutes for Medical Research at Northwell Health, a pioneer of vagus nerve research and author of the recent book, The Great Nerve: The New Science of the Vagus Nerve and How to Harness Its Healing Reflexes. This episode is brought to you by:Eight Sleep Pod Cover 5 sleeping solution for dynamic cooling and heating: EightSleep.com/Tim (use code TIM to get $350 off your very own Pod 5 Ultra.)AG1 all-in-one nutritional supplement: https://DrinkAG1.com/Tim (1-year supply of Vitamin D plus 5 free AG1 travel packs with your first subscription purchase.)Wealthfront high-yield cash account: https://Wealthfront.com/Tim (Start earning 4.00% APY on your short-term cash until you're ready to invest. And when new clients open an account today, you can get an extra fifty-dollar bonus with a deposit of five hundred dollars or more.) Terms apply. Tim Ferriss receives cash compensation from Wealthfront Brokerage, LLC for advertising and holds a non-controlling equity interest in the corporate parent of Wealthfront Brokerage. See full disclosures here.Timestamps:00:00 Tim's intro: why he dismissed vagus-nerve hype06:34 What the vagus nerve actually is, plus common myths11:31 Breaking news: FDA approval for SetPoint's RA implant + Kelly Owens's turnaround21:11 Inflammation 101: when healing turns harmful31:37 Bioelectronic medicine: from lab insight to real devices55:26 TNF, IL-1, and IL-6: immune drivers and what VNS modulates56:06 Exercise & recovery: vagal signals, IL-6, and adaptation56:30 Cold exposure & breathwork: sympathetic spike, parasympathetic payoff59:04 Chronic inflammation today: prevalence, diagnostics, and uncertainty59:53 Autoimmunity: genes, environment, infections01:01:08 Stress hormones, personality traits, and metabolic fallout01:05:41 VNS tech landscape: implants, focused ultrasound, and what's just TENS01:11:14 Ear maps, revisited: the real science behind auricular stimulation01:27:52 Ulf Andersson: auricular TENS, famotidine, and a depression turnaround01:36:48 Depression & inflammation: where VNS helps (and where it doesn't)01:41:38 Body-brain loop: how inflammation signals ride the vagus nerve01:42:56 Why VNS can lift mood: a working theory01:43:22 Ulf's setup: electrode placement and twice-daily routine01:44:37 Acupuncture, fertility, and plausible vagal links01:47:23 Chronic pain through an inflammation lens01:48:34 Neural “engrams”: how the brain can store inflammatory memories02:02:35 Cervical TENS vs. true VNS: mechanisms and open questions02:12:15 On stage with the Dalai Lama: blue energy and two vagus nerves02:16:55 Closing thoughts: self-care vs. medical devices, and what's next*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim's email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim's books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, Margaret Atwood, Mark Zuckerberg, Peter Thiel, Dr. Gabor Maté, Anne Lamott, Sarah Silverman, Dr. Andrew Huberman, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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The Ann & Phelim Scoop
"Who Lives and Dies?" Medical Research Vs. Ethics

The Ann & Phelim Scoop

Play Episode Listen Later Aug 20, 2025 66:38


This is our last show from Ireland for a while. We've had some very special houseguests, including our friends Alan and Lisa Robertson from Duck Dynasty and the Unashamed Podcast. They had a great time seeing the sights with us—watch the podcast to see our journey to a very interesting pub.Also on today's show, we reveal how the “nice people” in society are declaring YOU unfit for existence, from the womb to old age. We bring you a chilling interview exposing the questionable science and moral vacuum in the gold rush for designer babies.And watch the show to learn about the horrific expansions of Canada's assisted suicide law. You won't believe how common it has become and how much of America is heading down the same path.The New Yorker magazine—home of great writing and writers—has a racist on its staff. But don't worry—she's the fashionable kind. She only hates white people, so the left has no problem with that.We also have an exclusive story this week as we uncover the great veteran disability scam and how America's love affair with its military is allowing bad actors to rob us blind. Listen as the financial Jerry Springer exposes a veterans' scandal while trying to pound sense into some Gen Z deadbeats.Leave a comment wherever you get our content—you never know, we may read it on the show!Remember, we are a 501(c)(3) nonprofit. Please visit our website, unreportedstorysociety.com, and give what you can so we can keep bringing you our show and special projects. Your donation is tax-deductible.Click here to donate to the Unreported Story Society: ⁠https://unreportedstorysociety.com/⁠Did you know you don't have to wait a week to get the scoop? Subscribe to our Stories.io Substack for news and views every day.Click here to read Phelim's story on the abuse of VA disability benefits: https://phelimmcaleer.substack.com/p/exposing-the-great-veteran-disability?utm_campaign=email-half-post&r=58t52b&utm_source=substack&utm_medium=emailSubstack link: https://phelimmcaleer.substack.com/

NEJM This Week — Audio Summaries
NEJM This Week — August 21, 2025

NEJM This Week — Audio Summaries

Play Episode Listen Later Aug 20, 2025 23:14


Featuring articles on lung cancer, vasomotor symptoms in breast cancer, autoimmune pulmonary alveolar proteinosis, and high-risk cutaneous squamous-cell carcinoma; a review article on educational strategies for clinical supervision of AI use; a case report of a woman with fatigue and myalgias; a Sounding Board on vaccine policy in the U.S.; and Perspectives on preventive care at the Supreme Court, regulating private equity in health care, reforming the prescription drug user fee program, and on the consultant.