Podcasts about ludwig maximilians university munich

We're in Munich with Philipp Baaske, one of the best life science tools founder in Europe.We talked about the lessons building this life science tools business specialized in protein interactions. We also talked about the difficulty and rewards of entrepreneurship, and the impact of life science tools.___This episode is sponsored by NanoTemper Technologies, which performs protein characterization. Learn more at https://bit.ly/flotbio_nanotemper___⭐️ ABOUT THE SPEAKERPhilipp Baaske, a German biophysicist, co-founded NanoTemper Technologies in 2008 with Stefan Duhr. He earned his PhD from Ludwig-Maximilians-University Munich, specializing in biophysics. Baaske pioneered MicroScale Thermophoresis, advancing drug discovery research. He was Co-CEO for 16 years before becoming Executive Chairman in 2024. An award-winning innovator, he supports biotech and entrepreneurship as a business angel.

A new research paper was published in Aging (Aging-US) Volume 14, Issue 14, entitled, “Common electrocardiogram measures are not associated with telomere length.” Aging is accompanied by telomere shortening. Increased telomere shortening is considered a marker of premature aging. Cardiac aging results in the development of cardiac pathologies. Electrocardiogram (ECG) measures reflect cardiac excitation, conduction, and repolarization. ECG measures also prolong with aging and are associated with cardiac pathologies including atrial fibrillation. As premature prolongation of ECG measures is observed, researchers (Aenne S. von Falkenhausen, Rebecca Freudling, Melanie Waldenberger, Christian Gieger, Annette Peters, Martina Müller-Nurasyid, Stefan Kääb, and Moritz F. Sinner), from Ludwig-Maximilians-University Munich, Partner Site Munich Heart Alliance, German Research Center for Environmental Health, and Johannes Gutenberg University, hypothesized that such prolongation may be associated with telomere length. “We studied the large, community-based KORA F4 Study. Of 3,080 participants enrolled between 2006 and 2007 with detailed information on demographic, anthropometric, clinical, and ECG characteristics, 2,575 presented with available data on leukocyte telomere length.” Telomere length was determined by real-time quantitative PCR and expressed relative to a single copy gene. The researchers fitted multivariable adjusted linear regression models to associate the ECG measures RR-interval, PR-interval, QRS-duration, and heart rate corrected QTc with telomere length. In this cohort, the mean age was 54.9±12.9 years and 46.6% were men. Increased age was associated with shorter telomere length (p

Claudia Saalmueller is a yoga and performing arts teacher. She studied at the Iwanson International School of Contemporary Dance and holds a master degree of theatre sciences and education from the Ludwig Maximilians University Munich. Although dancing has always played a major role in her life she was searching for something calming and relaxing for her body and her mind. She found it in her yoga and meditation practice. She became an RYT 500 with the American Yoga Alliance, after finishing her teacher training in Vinyasa Flow at Airyoga Munich and in Rishikesh, India. Claudia is also specialized in teaching children and teenagers and Yin Yoga which she studied with Jo Phee at the Balance Yoga Institute Frankfurt Main.   I'm talking to Claudia about the right form of yoga for better sleep! I always joke that when I started teaching yoga two decades ago, yoga was not the sexy profession that it is today. Most people thought that yoga was boring. Fast forward a decade later, suddenly yoga was everywhere. Ranging from beer yoga to hot yoga and power yoga, everyone was trying to create a new form of yoga that identified with them personally rather than the age old ancient science that it is. Even today, we continue to have yoga explode into different forms, but are they all as good as they claim? Could your yoga practice be destroying your sleep? What's the right form of yoga to restore sleep? Two yogini have an exciting conversation over this!  In this episode, we dive into:  “Right Form Of Yoga For Better Sleep” Claudia's story and how did her interest in Yoga happen?  I've been teaching yoga for two decades now and your interest is in yin yoga. Claudia and I share a similar view of yoga based on this. Let's talk about different forms of yoga today, and how some forms of yoga might not be the right fit for someone struggling with poor sleep. Results of research studies indicate that older adults practicing yoga regularly had better overall sleep quality, less episodes of disturbed sleep, took less time to fall asleep, less day time dysfunction, less use of sleep medications and also felt more rested and energetic in the morning. What are the reasons for this profound impact?  Yoga is powerful in relieving stress and unwinding the nervous system. How does yoga actually do this and what kind of asanas and practices really work on the nervous system. What is yin yoga? What are the profound characteristics of this form of yoga that actually target better sleep? I recall the phrase that one hour of yoga nidra is equal or even better than 4-5 hours of better sleep. This is why I advice someone who has sleep very badly but has a hectic day ahead, to do an hour of yoga nidra. How does yoga nidra really support better sleep or even help improve energy on a day after very poor sleep? For more on Claudia Saalmueller, you can follow her: Website: www.danceyouryoga.de Facebook: https://www.facebook.com/Clouds.facebok.page Instagram: https://www.instagram.com/danceyouryoga.de/ -For more on Deepa, The Sleep Whisperer, be sure to follow her on Instagram https://www.instagram.com/mysleepwhisperer/  and https://www.instagram.com/phytothrive_yogini/ and on Facebook https://www.facebook.com/groups/sleepwhisperer and you can also mail Deepa at deepa@phytothrive.com or find her at www.phytothrive.com and www.sleepwhisperer.pro

This talk, "Memory And Conversion - Thomistic Ressourcement And Productive Non - Contemporaneity" was delivered at the inaugural 2018-2019 conference for the Thomistic Institute at the Angelicum in Rome. Richard Schenk, OP is a Dominican originally from California, and a member of the Holy Name Province (Berkeley). From 1982 to 1985 he was a research assistant at Leo Scheffczyk at the Ludwig-Maximilians-University Munich. He has published extensively on the theological anthropology of Thomas Aquinas, often in comparison with the works of Martin Heidegger and Karl Rahner. From 2003 to 2005, he also served as director of the Faith and Culture (ICF) Intercultural Forum for Studies (Washington, DC) in Washington, D.C. From 2011-2014 he was the president of the Catholic University of Eichstätt-Ingolstadt. Currently he is honorary professor at the University of Freiburg in the field of Christian philosophy of religion.

Regression models with lagged covariate effects are often used in biostatistical and geo- physical data analysis. In the difficult and all-important subject of earthquake research, strong long-lasting rainfall is assumed to be one of many complex trigger factors that lead to earthquakes. Geophysicists interpret the rain effect with an increase of pore pressure due to the infiltra- tion of rain water over a long time period. Therefore, a sensible statistical regression model examining the influence of rain on the number of earthquakes on day t has to contain rain information of day t and of preceding days t − 1 to t − L. In the first part of this thesis, the specific shape of lagged rain influence on the number of earthquakes is modeled. A novel penalty structure for interpretable and flexible estimates of lag coefficients based on spline representations is presented. The penalty structure enables smoothness of the resulting lag course and a shrinkage towards zero of the last lag coefficient via a ridge penalty. This additional ridge penalty offers an approach to another problem neglected in previous work. With the help of the additional ridge penalty, a suboptimal choice of the lag length L is no longer critical. We propose the use of longer lags, as our simulations indicate that superfluous coefficients are correctly estimated close to zero. We provide a user-friendly implementation of our flexible distributed lag (FDL) ap- proach, that can be used directly in the established R package mgcv for estimation of generalized additive models. This allows our approach to be immediately included in com- plex additive models for generalized responses even in hierarchical or longitudinal data settings, making use of established stable and well-tested algorithms. We demonstrate the performance and utility of the proposed flexible distributed lag model in a case study on (micro-) earthquake data from Mount Hochstaufen, Bavaria with focus on the specific shape of the lagged rain influence on the occurrence of earthquakes in different depths. The complex meteorological and geophysical data set was collected and provided by the Geophysical Observatory of the Ludwig-Maximilians University Munich. The benefit of flexible distributed lag modeling is shown in a detailed simulation study. In the second part of the thesis, the penalization concept is extended to lagged non- linear covariate influence. Here, we extend an approach of Gasparrini et al. (2010), that was up to now unpenalized. Detailed simulation studies illustrate again the benefits of the penalty structure. The flexible distributed lag nonlinear model is applied to data of the volcano Merapi in Indonesia, collected and provided by the Geophysical Observatory in Fürstenfeldbruck. In this data set, the specific shape of lagged rain influence on the occurrence of block and ash flows is examined.

Are you a lark or an owl? Are you at your best in the morning or the evening? Linda Geddes meets the scientists who are exploring the differences between larks and owls. At the University of Surrey's Sleep Research Centre she talks to its director, professor Derk-Jan Dijk, and finds out her own chronotype by filling in a questionnaire. Linda discovers why we have circadian rhythms and why they do not all run at the same rate. Dr Louis Ptacek from the University of California, San Francisco, explains his investigation of the genes of families whose members get up very early in the morning and of those who get up very late. She finds out why our sleep patterns change as we age – teenagers really are not good at getting up in the morning. Professor Mary Carskadon from Brown University explains that although some schools have experimented with a later start there is no plan to put this into universal practice. Linda talks to Professor Til Roenneberg from Ludwig-Maximilians-University Munich about his concept of social jetlag. And she hears about research trying to reduce the exhaustion often suffered by shift workers. Dr Steve Lockley of Harvard University tells her about using blue light to improve the wellbeing of people with medical conditions.

Dance on a Volcano: A Quarter Century of Experimental First Ascents Dr. Donald B. Dingwell, Secretary General of the European Research Council, President of the European Geosciences Union, Ludwig-Maximilians University Munich, Department of Earth and Environmental Science Volcanic activity has been a continuous companion to mankind. A century ago, experimental Earth science began to redefine our understanding of the Earth's interior. Although physical volcanology had been exclusively observational, new experimental science is making vast advances in the science of eruptive processes. Dr. Dingwell will guide us through some of the highlights of the last quarter century of experimental volcanology. Co-hosted by the Carnegie Institution for Science with the Embassy of Austria, the Embassy of Switzerland, and the Delegation of the European Union to the United States.

Are you a lark or an owl? Are you at your best in the morning or the evening? Linda Geddes meets the scientists who are exploring the differences between larks and owls. At the University of Surrey's Sleep Research Centre she talks to its director, Professor Derk-Jan Dijk, and finds out her own chronotype by filling in a questionnaire. Linda discovers why we have circadian rhythms and why they don't all run at the same rate. Dr Louis Ptacek from the University of California, San Francisco, explains his investigation of the genes of families whose members get up very early in the morning and of those who get up very late. She finds out why our sleep patterns change as we age - teenagers really aren't good at getting up in the morning. Professor Mary Carskadon from Brown University explains that although some schools have experimented with a later start there is no plan to put this into universal practice. Linda talks to Professor Til Roenneberg from Ludwig-Maximilians-University Munich about his concept of social jetlag. And she hears about research trying to reduce the exhaustion often suffered by shift workers. Dr Steve Lockley of Harvard University tells her about using blue light to improve the wellbeing of people with medical conditions.

Lipid metabolism alteration and statin intake in myotonic dystrophies A. Schmidt, MS a; L. Kirzinger, MS a, W. Kress, PhD b, and B. Schoser, MD a a Friedrich-Baur Institute, Department of Neurology, Ludwig Maximilians University Munich, Munich, Germany b Institute of Human Genetics, University of Würzburg, Würzburg, Germany. Background: There have been no systematic reports on lipid metabolism alteration in myotonic dystrophies. We assessed the frequency, type, and severity of lipid alteration in both types of DM. Furthermore, the frequency of statin intake and side effects was investigated. Methods: A retrospective multicenter study was conducted. 134 DM2 patients and 29 DM1 patients participated by completing questionnaires. Additionally, their clinical and serological records, including blood lipid parameters for dyslipoproteinemia (cholesterol, HDL, LDL and TG) were screened and reviewed. Results: 71.6% of DM2 and 55.2% of DM1 patients show evidence to suffer from dyslipoproteinemia. In DM2 and DM1 patients the age of onset of dyslipoproteinemia was 47.6y±15.1 and 46.2y±9.7, respectively. Comparing both DM groups, all measured parameters did not differ statistically significant. Nevertheless, comparing all lipid parameters of both types of DM with an average German population data set, we could find a no significant discrepancy for DM1 patients (Cholesterol: p=0.435; HDL: p=0.129), but for DM2 patients (Cholesterol p=0.021; HDL: p=0.001). 23.1% of DM2 and 11.1% of DM1 patients were treated with statins. 50% of all patients discontinued statin therapy because of side effects. Conclusions: According to Robert-Koch-Institute, Germany, one third of German adults show elevated cholesterol levels, which is significantly lower than the rate found here in DM patients. With this high rate of dyslipoproteinemia in DMs, it seems to be obvious, that DM patients show a predisposition for this metabolic disorder. Furthermore, compared with data from Robert-Koch-Institute, DM patients (DM2 23.1%, DM1 11.1%) use significantly more statins than the German average. In addition, the rate of discontinuation is high based on side effects like augmented symptoms (hyperCKemia in 27.8% DM2, muscle pain or weakness in 33.3% DM2) in relation to former studies revealing statin side effects in one of 10000 patients.

Introduction: Since more than 50 years, various surgical procedures have been described for congenital Brown’s syndrome. However most showed low success rates and some even severe side effects. The aim of this retrospective study was to evaluate the results of superior oblique posterior tenectomy. This technique was introduced in 1996 by Mühlendyck. Since this first description no other results have been published by others. Patients and methods: 21 patients with congenital Brown’s syndrome (aged 2 to 29 years) were operated between 2001 and 2006, in the Department of Ophthalmology, Ludwig-Maximilians-University Munich. In all patients, intraoperative forced ductions showed severe passive restriction of elevation in adduction and superior oblique posterior tenectomy was performed as a primary procedure. The squint angle (vertical and horizontal deviation in primary position, lateral gaze, up/down gaze), active elevation in adduction, abnormal head posture at distance fixation, binocular vision (in primary position and anomalous head posture) were assessed in each case. All the measurements were performed 1 day before, 1 month and 3 months after surgery. Eight patients were examined 6-24 months after primary procedure. Results: Intraoperatively, a tight or very tight posterior part of the superior oblique tendon was found in 87 % of operated eyes. At the end of the operation, passive motility in adduction became free (14 eyes) /almost free (7 eyes) on the majority of operated patients (totally 23 eyes). Inspite of free passive motility, the active monocular elevation in adduction was only slightly improved by 0.5 mm to 5 mm (mean 2.25 mm), like hypotropia in primary position, which was improved by 1 to 12 deg (mean 4 deg). Better results regarding hypotropia in primary position were noted when the preoperative vertical deviation in primary position was more than 10 deg. However in cases with preoperative hypotropia less than 10 deg, a better fusion was obtained. Preoperatively, 17 patients showed an abnormal head posture. Postoperatively, 12 of them totally gave up their posture and 5 improved partially. Of 8 cases with a long-term follow-up, 5 showed unchanged measurements of vertical deviation in primary position, monocular elevation in adduction and head posture. 3 patients with a long-term follow-up had further surgery and an improvement of vertical deviation in straight gaze and active elevation in adduction. Conclusion: The use of superior oblique posterior tenectomy significantly improves abnormal head posture and also improves alignment and ocular rotations in patients with congenital Brown’s syndrome. We did not see any serious side effect like consecutive superior oblique muscle underaction (as in superior oblique tenotomy or recession) and no foreign body extrusion (as in silicone superior oblique tendon expander). So the superior oblique posterior tenectomy is a safe and effective procedure with regard to the head posture. The fact that the passive motility had dramatic improved postoperatively, but the active elevation in adduction improved only slightly, suggests a paretic/ dysinnervational component to the superior oblique in some patients. From this point of view, a therapeutic algorithm depending on intraoperative/ radiological findings in congenital Brown’s syndrome is proposed.

Canine Leptospirosis in Southern Germany In this study, data of 337 dogs with clinically suspected leptospirosis was evaluated. The dogs were presented to the Clinic for Small Animal Medicine (Medizinische Kleintierklinik) of the Ludwig Maximilians University Munich, Germany, between 1990 and 2004. In all dogs, a microagglutination test used to detect leptospiral antibodies against eight different Leptospira serovars was performed. The aim of the first study was to determine the presence of antibodies against various Leptospira serovars in dogs with clinical leptospirosis in Southern Germany and to compare serovars in regard to history, clinical signs, laboratory findings and survival rate. The purpose of the second study was to identify the Leptospira serovars predominantly inducing antibodies in dogs in Southern Germany and to determine which serovars mainly cause disease. Furthermore, possible predisposition in respect to breed, sex, and age was investigated. 48 % (162) of 337 dogs had antibodies against at least one Leptospira serovar. With the exception of antibodies against the vaccinal serovars copenhageni (70 %) and canicola (38 %), antibodies against grippotyphosa (33 %), bratislava (19 %) saxkoebing (10 %) and sejroe (8 %) were detected most frequently. Of the dogs with antibodies, 26 % (42) had the disease leptospirosis. These dogs most frequently tested positive for antibodies against grippotyphosa (31 %), followed by antibodies against saxkoebing (24 %), copenhageni (17 %), canicola (12 %) and bratislava (7 %). Thus, while antibody titers against vaccinal serovars were found in many dogs, the disease leptospirosis was mainly caused by the serovars grippotyphosa and saxkoebing. Previous studies have suggested that certain serovars are commonly associated with particular clinical symptoms and laboratory findings. However, this was not confirmed in the current study. The ratio of dogs having antibodies against leptospirosis without clinical leptospirosis to dogs with the disease leptospirosis was considerably lower in the serovar saxkoebing (1.6:1) than in other serovars (bratislava 10:1, grippotyphosa 4:1). This may be indicative of a higher pathogenicity of saxkoebing compared to other serovars. Presence of antibodies was diagnosed significantly more often in Bernese Mountain dogs than in other breeds. Also, the disease leptospirosis was significantly more often in this breed. Increasingly, nonvaccinal serovars are the cause of the disease leptospirosis. Leptospirosis vaccines currently available in Europe only contain copenhageni and canicola strains. Since these vaccines are not cross-protective against other serovars, they offer no protection against grippotyphosa and saxkoebing, the serovars most commonly associated with clinically manifest leptospirosis in Germany. A recently developed vaccine, licensed in the USA, contains grippotyphosa and pomona strains, either as a bivalent or as a quadrivalent product in combination with copenhageni and canicola. This study suggests that serovars grippotyphosa and saxkoebing should be added to leptospirosis vaccines available in Germany.

The present thesis deals with the development of nanoparticles based on the proteinaceous macromolecule gelatin as delivery system for various nucleotide-based drugs. Since a method to produce homogenous nanoparticles was already described in principle (Coester et al. 2000), it was the first approach to characterize, optimize, and standardize this manufacturing process. The next goal was to advance these plain gelatin nanoparticles via modification of the surface towards a delivery system for nucleotide-based drugs. Subsequent to this, the newly established carrier system should be evaluated in preclinical trials. In addition to these main projects, it was also an aim of this study to investigate and influence the biodistribution of gelatin nanoparticles. Due to the multitude of independent projects, the present work is divided into five self-contained chapters. In Chapter I, fundamental research data concerning the preparation of gelatin nanoparticles is described. Thereby, the work was focused on process optimization of the existing preparation procedure. Moreover, new analytical tools to characterize gelatin and the gelatin nanoparticles are introduced. Chapter II features the data that were produced in cooperation with the Department of Pharmaceutical Biotechnology at Ludwig-Maximilians-University Munich. In this cooperation, plasmid DNA was bound onto the surface of previously modified gelatin nanoparticles by electrostatic interactions. Subsequent preparation optimization, this simple non-viral gene delivery system was investigated in vitro on murine melanoma cells. The major project of this work, the development and evaluation of gelatin nanoparticles as carrier system for immunogenic so called CpG oligonucleotides is presented in Chapter III and Chapter IV. The data has been generated in cooperation with the Department of Internal Medicine at the Ludwig-Maximilians-University Munich and initially during a 3-month research stay at the Faculty of Pharmacy at the University of Alberta in Edmonton, Canada. Chapter III features extensive in vitro investigations on the respective primary murine and human target cells such as dendritic cells and B cells, whereas in Chapter IV, the results of in vivo experiments are presented. Here, the immunogenic effects of CpG oligonucleotide-loaded nanoparticles alone and their adjuvant activity in combination with the model protein antigen ovalbumin (OVA) were explored. In the final chapter, Chapter V, first PEGylation experiments of gelatin nanoparticles are described, with special emphasis on the establishment of new analytical tools for the quality control of the PEGylation process. In the second part of this chapter, radiolabeling strategies were developed in cooperation with the Department of Nuclear Medicine (TU Munich) to enable real-time in vivo tracking of the gelatin nanoparticles via positron emission tomography (PET).

Aim: The aim of this retrospective cast study was to determine the spectrum of treatment possibilities with the tooth positioning appliance. The data collecting process and the measurements should be done by specially developed digital computer-based methods. Patients and Methods: 738 teeth of 28 individuals, treated in the department of orthodontics at the Ludwig-Maximilians-University Munich, were examined over the time period of treatment with the tooth positioning appliance. The casts at the end of multiband/ multibracket treatment, the setup models and the casts at the end of positioner treatment were digitalized. These digital images were measured and then examined by the computer software programme DiagnoseFix 2001©. The results were mathematically categorized and statistically analysed with SPSS 10.0, mostly using non-parametric tests. Results: The newly developed method on the basis of the programme DiagnoseFix 2001© is cheap, sufficiently accurate and can easily be adapted. It allows the fast and easy calculation of distances and angles from two-dimensional digital pictures. It was found that a mathematically defined axis of symmetry is a more accurate reference for model measurements than the palatine raphe. The tooth positioning appliance is not so efficient in the prevention of a relapse. However the tooth positioner can move teeth effectively according to the setup in a sagittal and transversal direction and rotate them. The extent of movements is nearly independent of anamnestic parameters as is age or gender of the patient. For all kinds of movement one should consider an overcorrection in the setup of approximately a third larger than the desired result. The positioner-induced tooth movements were about 4.8° in rotation, 0.6 mm in the sagittal direction and 0.4 mm in the transversal direction. The average success rate was 62 % in rotations, 48 % for sagittal and 50 % for transversal effects. A large interindividual range concerning the success rate could be observed (p