Nucleotide sequences
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5 episodes with Telomere
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3 episodes with Telomere
Lauren Rosenberg, a highly experienced Physician Associate, has dedicated nearly two decades to Internal Medicine and Health Optimization. Driven by a passion for preventative care, Lauren founded Vent Health to shift the focus from disease treatment to prevention. She specializes in a personalized approach that blends genetics, epigenetics, biomarkers, and lifestyle factors to tailor health interventions that extend and optimize each patient's health span. Lauren's practice includes prescribing peptides (GLP, CLP/GIP) for weight loss, insulin resistance, pre-diabetes, etc. This episode concentrates on all the questions about GLP's, the prescription based Ozempic and others, as well as the Compound Pharmacy GLP's that can often times be less expensive. Heather and Lauren also cover the common side effects, and how to manage them. In this episode you will learn other health benefits of these peptides, and who can benefit from them as well as practical tips for getting started on GLP-1 Therapy. Lauren is a frequent speaker at the Age Management Medicine Group (AMMG) and the American Academy of Anti-Aging Medicine (A4M) conferences. Lauren's practice includes Cardiology prevention: Diagnostics and AI analysis to detect dangerous plaque and calcium; advanced lipid testing and cardiovascular genetics Longevity biomarkers: DNA methylation for biological age, VO2 max testing, Telomere health; Therapeutic plasma exchange Cancer prevention: methylated DNA screens, preventative MRIs, tumor marker testing. We will have Lauren back to discuss all these other longevity and optimum health subjects. This episode concentrates on the information pertaining to Peptides, GLP's etc as they are so popular right now. If you want to contact Lauren for more info, you can reach her via her site: https://myventhealth.com and go to the contact page. Or email: vent@myventhealth.com Social Media: IG: https://www.instagram.com/iamheathert/ You Tube: https://youtube.com/@iamheathert?si=ZvI9l0bhLfTR-qdo Learn more about your ad choices. Visit megaphone.fm/adchoices
Today's wisdom comes from The Telomere Effect by Elizabeth Blackburn, Ph.D. If you're loving Heroic Wisdom Daily, be sure to subscribe to the emails at heroic.us/wisdom-daily. And… Imagine unlocking access to the distilled wisdom form 700+ of the greatest books ever written. That's what Heroic Premium offers: Unlimited access to every Philosopher's Note. Daily inspiration and actionable tools to optimize your energy, work, and love. Personalized coaching features to help you stay consistent and focused Upgrade to Heroic Premium → Know someone who'd love this? Share Heroic Wisdom Daily with them, and let's grow together in 2025! Share Heroic Wisdom Daily →
BUFFALO, NY — March 26, 2025 — A new #research paper was #published in Aging (Aging-US) on January 29, 2025, in Volume 17, Issue 2, titled “Diet, lifestyle and telomere length: using Copula Graphical Models on NHANES data.” Researchers Angelo M. Tedaldi, Pariya Behrouzi, and Pol Grootswagers from Wageningen University and Research used data from the National Health and Nutrition Examination Survey (NHANES) to explore how diet and lifestyle affect telomere length, a key marker of cellular aging. They found that inflammation—rather than diet, exercise, or smoking—had the strongest and most consistent association to telomere shortening. The findings suggest that reducing inflammation may be more effective than dietary changes in slowing down the aging process at the cellular level. Telomeres are protective caps at the ends of chromosomes that get shorter as we age. When they become too short, cells lose the ability to divide properly, which can contribute to aging and age-related diseases. Previous studies suggested that healthy habits might protect telomeres, but many focused on a small number of factors and did not account for important elements like inflammation or differences in blood cell composition. This study aimed to take a more complete, data-driven approach. The research team analyzed health data from over 7,000 U.S. adults collected between 1999 and 2002. Using a method called Copula Graphical Modeling, they examined more than 100 variables—such as diet, physical activity, smoking, and blood biomarkers—across three age groups: Young (20–39 years), Middle (40–59 years), and Old (60–84 years). They found that telomere length was most strongly associated to age, levels of C-reactive protein (CRP)—a common marker of inflammation—and gamma-tocopherol, a form of vitamin E found in the blood. Higher CRP levels were consistently associated with shorter telomeres, especially in younger and middle-aged adults. The results suggest that while lifestyle factors like diet and exercise still play a role, their impact on aging may be indirect—mainly through their influence on inflammation. This finding shifts the focus toward managing chronic inflammation as a potentially more effective way to preserve telomere length and promote healthy aging. “The central role played by CRP and the marginal role of antioxidants suggests that telomeres are particularly vulnerable not to oxidative stress, but to inflammation; and they should be protected against it.” The study challenges earlier research that looked at individual lifestyle factors isolated. By using a more advanced and inclusive method, this analysis offers a clearer picture of how health behaviors, biological markers, and aging are connected. Although this research cannot prove a cause-and-effect relationship, it strongly supports the idea that inflammation plays a key role in cellular aging. The authors recommend further long-term studies to better understand how inflammation affects telomere length over time. In the meantime, reducing chronic inflammation may be one of the most important steps to help support healthy aging and reduce the risk of age-related diseases. DOI - https://doi.org/10.18632/aging.206194 Corresponding author - Angelo M. Tedaldi - angelomt1999@gmail.com Video short - https://www.youtube.com/watch?v=C2yXfF7iY6c Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Please visit our website at https://www.Aging-US.com and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
What if you could slow down aging, or even reverse it?This is the one thing all of us anti-aging doctors aim for: the reversal of aging, not just physically, but mentally as well.My guest on the podcast this week, the brilliant Dr. Bill Lawrence, is living proof that we can reprogram aging at the cellular level. At 78 years old, his cellular age is just 23 based on telomere analysis. How is that even possible? Well, he has spent years researching peptide bioregulators, a Russian breakthrough in longevity science that restores DNA repair, regenerates organs, and slows aging—and it's working!In this week's episode of The Dr. Joy Kong Podcast, we discuss his research in more detail. He and I also talk about how peptides can reduce mortality, the real causes of aging, how stress can impact your longevity, and so much more.If you're ready to live a longer and healthier life, then don't miss this episode!Tune in now. Key Takeaways:Introduction (00:00)Meet Dr. Lawrence (02:52)Peptides' anti-aging qualities (16:07)Telomere and epigenetic studies (37:45)Clinical study results (39:41)How peptides regenerate organs (52:30)The future of longevity research (01:14:43)Changing the expectations around aging (01:26:32)Why is conventional medicine not keeping up? (01:31:04)Additional Resources:✨ Use coupon code DRJOY to get 15% off your first purchase of bioregulators: https://profound-health.com/?aff=DRJOY✨ Reference list of bioregulators:https://naturesmarvels.com/wp-content/uploads/peptide-bioregulators-and-recommended-protocols-scaled.jpg✨ Learn more about how to live a long and pain-free life: https://joykongmd.com/ ✨ Follow me on Facebook: https://www.facebook.com/stemcelldrjoy/ ✨ Follow me on Instagram: https://www.instagram.com/dr_joy_kong/ —Dr. Joy Kong is a regenerative medicine and anti-aging expert. Her podcast is part of her mission to reduce suffering and elevate happiness. Join us every week for the latest holistic health insights that will help you live a long and pain-free life.
In this episode of Shift with CJ, host CJ takes a deep dive into Hyperbaric Oxygen Therapy (HBOT) with Maria Nosal, a leading expert from OxyLife Dubai. Together, they uncover the science, benefits, and myths behind this cutting-edge therapy that has been embraced by celebrities, athletes, and biohackers worldwide.Maria explains how pressurized oxygen therapy can accelerate healing, fight inflammation, optimize brain function, and even reverse aging. She breaks down the differences between soft-shell and hard-shell hyperbaric chambers, why oxygen is more than just air—it's a nutrient, and how HBOT is revolutionizing wellness, sports recovery, and medical treatments.The discussion also touches on stem cell activation, mitochondrial energy (ATP) production, and telomere lengthening, which research suggests can slow biological aging by up to 25 years. CJ and Maria explore the accessibility challenges of HBOT and envision a future where oxygen therapy is as common as gyms, wellness centers, and even ambulances.If you're looking for a powerful tool to improve performance, speed up recovery, or enhance longevity, this episode is packed with science-backed, actionable insights to transform your health.Key Takeaways:✅ HBOT maximizes oxygenation, reducing inflammation and enhancing cellular function. ✅ Telomere lengthening by 20% could mean a 25-year age reversal. ✅ Pro athletes use HBOT for brain function, muscle recovery, and injury healing. ✅ Hard chambers are medical-grade, while soft chambers work great for biohackers. ✅ The future? Hyperbaric chambers in gyms, spas, and even ambulances.5 Ways to Improve Your Health Today:✔ Breathe smarter – Try deep breathing, fresh air, or altitude training. ✔ Lower inflammation – Use red light therapy, cold therapy, and anti-inflammatory foods. ✔ Boost ATP production – Eat mitochondria-supporting nutrients like CoQ10 and NAD+. ✔ Enhance recovery – Use fasting, sauna, and structured breathwork. ✔ Stay curious – Keep learning about HBOT, biohacking, and longevity science.Listen now to unlock the next level of performance, recovery, and health!
In this fascinating first installment of a three-part series, we dive deep into the groundbreaking world of telomere science with Dr. Bill Andrews, a pioneering researcher in the field of ageing and longevity. Known for his revolutionary work on telomeres and their role in cellular aging, Dr. Andrews shares insights into how his research is paving the way for the ultimate goal: curing aging. Dr. Andrews, the founder of Sierra Sciences, has dedicated his life to understanding the root causes of ageing at the molecular level. This episode covers the basics of telomeres, the science behind their shortening, and why maintaining telomere length is essential for longevity and disease prevention. Key Discussion Points: What Are Telomeres? Telomeres are protective caps at the ends of chromosomes that safeguard our genetic material during cell division. As we age, telomeres shorten, leading to cellular dysfunction and ageing. Why Telomeres Matter in Aging: Telomere shortening is a major driver of ageing and age-related diseases. Dr. Andrews explains the link between telomeres and cellular senescence, inflammation, and chronic illnesses. Dr. Bill Andrews' Mission: The story behind Sierra Sciences, a biotechnology company dedicated to discovering drugs that activate the telomerase enzyme. Telomerase can rebuild and lengthen telomeres, potentially reversing cellular aging. The Science of Telomerase Activation: Current progress in identifying compounds that safely activate telomerase. Challenges and breakthroughs in the quest to develop anti-ageing therapies. Ethics and Implications of Curing Aging: Dr. Andrews discusses the societal, ethical, and philosophical implications of extending human lifespan. Addressing misconceptions about anti-ageing science. What You Will Learn: The fundamental role of telomeres in ageing and disease. How telomerase activation could revolutionise health and longevity. The current state of telomere research and its future potential. The challenges and ethical questions surrounding anti-ageing technologies. Don't miss the next episode in this series, where Dr. Andrews delves deeper into telomerase activation and the latest breakthroughs in curing aging. Subscribe to "Pushing the Limits" and share this episode with anyone passionate about health, science, and longevity! Bio: Dr. Bill Andrews is a molecular biologist, inventor, and renowned expert in the field of telomere science. He has over three decades of experience in biotech, including significant contributions to telomerase research. Dr. Andrews holds over 50 U.S. patents related to telomerase activation and has authored numerous scientific papers. Through his work at Sierra Sciences, he aims to unlock the secrets of human longevity and help people live healthier, longer lives. As a scientist, athlete, and executive, Bill continually pushes the envelope and challenges convention. He has been featured in Popular Science, The Today Show, and numerous documentaries on the topic of life extension including, most recently, the movie The Immortalists in which he co-stars with Dr. Aubrey de Grey. Bill has been a medical researcher in biotech since 1981, focusing on cancer, heart disease, and inflammation research, though his passion has always been ageing. In the early-to-mid 1990s, while at Geron Corporation, Bill led the research to discover both the RNA and protein components of the human enzyme called telomerase. This enzyme is responsible for preventing telomeres from shortening in human reproductive cells, and this is why our children are born younger than we are even though they come from our old cells. Inducing this enzyme to lengthen telomeres in all our cells, not just our reproductive cells, to reverse aging and declining health due to aging, is the principal goal of Sierra Sciences and Sierra Holdings. Website: https://sierrasci.com/ The Immortalists Movie: https://theimmortalists.com/watch/ Best Choice Medicine petition, that you can sign today: https://www.bestchoicemedicine.com/
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The affect#Senescent Cells or "Zombie" Cells has on our Skin and how it #ages us are examined in this podcast. The effect that #DNA damage has by #envirnomental factors, #weight gain lack of #NAD and other important nutrients. The idea of #Telomere size, #sirtuins and #collagen and #elastin production is explored on this Podcast. Common Aesthetic procedures like #Microneedling #Peels #Lutronic #Ultra #Laser are all discussed
Lauren Rosenberg, a highly experienced Physician Associate, has dedicated nearly two decades to Internal Medicine and Health Optimization. Driven by a passion for preventative care, Lauren founded Vent Health to shift the focus from disease treatment to prevention. She specializes in a personalized approach that blends genetics, epigenetics, biomarkers, and lifestyle factors to tailor health interventions that extend and optimize each patient's healthspan. Lauren's practice includes prescribing peptides (GLP, CLP/GIP) for weight loss, insulin resistance, pre-diabetes, etc. This episode concentrates on all the questions about GLP's, the prescription based Ozempic and others, as well as the Compound Pharmacy GLP's that can often times be less expensive. Heather and Lauren also cover the common side effects, and how to manage them. In this episode you will learn other health benefits of these peptides, and who can benefit from them as well as practical tips for getting started on GLP-1 Therapy. Lauren is a frequent speaker at the Age Management Medicine Group (AMMG) and the American Academy of Anti-Aging Medicine (A4M) conferences. Lauren's practice includes Cardiology prevention: Diagnostics and AI analysis to detect dangerous plaque and calcium; advanced lipid testing and cardiovascular genetics Longevity biomarkers: DNA methylation for biological age, VO2 max testing, Telomere health; Therapeutic plasma exchange Cancer prevention: methylated DNA screens, preventative MRIs, tumor marker testing. We will have Lauren back to discuss all these other longevity and optimum health subjects. This episode concentrates on the information pertaining to Peptides, GLP's etc as they are so popular right now. Sponsor: Head to AirDoctorPro.com and use promo code HEATHER to get UP TO $300 off today! If you want to contact Lauren for more info, you can reach her via her site: https://myventhealth.com and go to the contact page. Or email: vent@myventhealth.com Website: www.heatherthomson.com Social Media: IG: https://www.instagram.com/iamheathert/ You Tube: https://youtube.com/@iamheathert?si=ZvI9l0bhLfTR-qdo Learn more about your ad choices. Visit megaphone.fm/adchoices
Wie wäre es, wenn du den Code für deine optimale Ernährung entschlüsseln könntest – ein Meta-Ernährungscode, der die besten Prinzipien aus Wissenschaft und Praxis vereint, um deine Gesundheit zu maximieren und dein Leben zu verlängern? In dieser Episode der Flowgrade Show spreche ich mit Prof. Dr. Sven Voelpel, einem führenden Experten für Langlebigkeit, über seinen revolutionären Ansatz: den Meta-Ernährungscode. Sven zeigt, wie du durch bewusste Entscheidungen in deiner Ernährung, eine basische Lebensweise und die Kraft des Bewusstseins die Grundlagen für ein erfülltes und gesundes Leben schaffen kannst. Wir diskutieren, wie du mithilfe des Meta-Ernährungscodes die besten Ernährungssysteme kombinierst, warum Vielfalt in der Ernährung essenziell ist und wie Wildkräuter, basische Lebensmittel und einfache Gewohnheiten deinen Körper und Geist unterstützen können. Sven geht außerdem darauf ein, warum die Verbindung von Wissenschaft und Lebensstil der Schlüssel zur Langlebigkeit ist und wie Kooperation über Wettbewerb in deinem Leben zu mehr Balance und Zufriedenheit führt. ► Über Prof. Dr. Sven Voelpel Prof. Dr. Sven C. Voelpel ist ein Visionär, Bestseller-Autor und Professor für Betriebswirtschaftslehre an der Constructor University Bremen. Als einer der führenden Altersforscher verbindet er Wissenschaft mit praktischen Ansätzen, um Lebensqualität und Langlebigkeit nachhaltig zu verbessern. Er ist Gründungspräsident des WISE Demographie Netzwerks und hat über 200 Publikationen zu den Themen demografischer Wandel, Diversity, Leadership und Innovation veröffentlicht. ► FlowFest 2025 – Entdecke den Code für dein optimales Leben Vom 3. bis 6. Juli 2025 erlebst du beim FlowFest 2025 in München ein Event, das dich mit neuen Ideen, tiefer Verbundenheit und praxisorientierten Tools inspiriert. Mit visionären Vorträgen, interaktiven Workshops und echter Community steht das FlowFest dieses Jahr im Zeichen der Verbundenheit – mit dir selbst, anderen und deiner Gesundheit. Sei mit dabei! Hier kannst du dir Tickets für das Event sichern. ► Ein großer Dank an unseren Partner Avea Life Langlebigkeit beginnt mit der richtigen Ernährung, doch manchmal braucht unser Körper zusätzlich Unterstützung. Hier kommt Avea Life ins Spiel – ein Unternehmen, das sich auf hochwertige Longevity-Supplements spezialisiert hat. Mit Produkten wie NMN, dem Booster oder auch Biomind hilft Avea, deinen Zellstoffwechsel zu optimieren und deine Gesundheit langfristig zu stärken. Mit dem Code FLOWGRADE erhältest du 15% Rabatt auf deine Bestellung * ► ForYou – Longevity für Zuhause ForYou bietet einen Longevity-Test an, der es dir ermöglicht, dein biologisches Alter anhand der Länge deiner Telomere zu bestimmen. Mit einem einfachen Wangenabstrich erhältst du wertvolle Einblicke in deinen Gesundheitszustand und dein biologisches Alter – eine großartige Möglichkeit, dein Leben bewusst und gesund zu gestalten. Wir freuen uns, dass ForYou auch das FlowFest 2025 unterstützen wird, um noch mehr Menschen die Möglichkeit zu geben, in ihre persönliche Langlebigkeit und Gesundheit zu investieren. Mehr dazu HIER * Go for Flow. ► Weiterführende Links: • Sven Voelpels Bücher • Tickets zumFlowFest 2025 • Avea Life Supplemente (15% Rabatt mit Flograde) * • ForYou – Longevity für Zuhause ► Kontakt • YouTube Kanal abonnieren • Flowgrade Website • Flowgrade Instagram • FlowTribe Community • Mail info@flowgrade.de * Affiliate Link / Werbung
Sun, 22 Dec 2024 10:23:41 +0000 https://schlafversteher.podigee.io/92-ausblick25 151606dc912cf88a144a1a2927ef2c29 Genau in dieser Zeit ist von Besinnlichkeit oft nur wenig Spur Man muss nur kurz Innehalten - und sich dessen bewusst werden Das Thema der Woche: Alle Jahre wieder … In dieser Zeit kommen Urlaubs- und Jahresend-Problematiken zusammen. Sowie, dass Erwartungen und Erledigungs-Zwänge auf einander treffen. Alles dies lässt uns schlechter schlafen und wir fangen wir uns am Ende auch noch unnötige Erkältung ein. Unser Podcastfolgen und Empfehlungen zum Thema: #049 - Sünden zur Festzeit abmildern #050 - Silvester und ein guter Plan für das neue Jahr #086 - Immunsystem- Krank zum Urlaubsbeginn Teaser für das Jahr 2025 Geplante neue Podcastfolgen für das Jahr 2025: Käse und Schlafapnoe - was hat das miteinander zu tun? Demenz und Alzheimer Schwitzen in der Nacht Frequenzen für den besseren Schlaf Der richtige Umgang mit Baldrian Kissen und die besten Schlafpositionen im Bett Telomere Update - länger jung bleiben Kaffee News Jetzt wünschen wir euch eine besinnliche Weihnachtszeit und alles Gute für das neue Jahr 2025! Über gute Kommentare und eine positive Bewertung würden wir uns sehr freuen. Bei Fragen oder dem Wunsch mitzumachen: info@schlafversteher.de (wir behandeln euere Daten vertraulich) Überall da, wo es Podcasts gibt: https://www.schlafversteher.de/abos/ Mehr Infos finden Sie hier: https://www.schlafversteher.de Die Schlafversteher, eine Produktion der vAL Ton, Schnitt und unsere unermüdliche Gastgeberin: Michaela von Aichberger Redaktion und unser unnachgiebiger Experte: Andreas Lange full no Telomere,Alzheimer,Demenz Michaela von Aichberger & Andreas Lange
Send us a textIn this insightful episode, I am joined by Chris Mirabile, a visionary in the field of longevity and the founder of Novos, a company at the forefront of combating aging through science-backed strategies and natural innovations. Chris shares his personal journey of health challenges and triumphs, which led him to a lifelong commitment to understanding the science of aging and optimizing human potential. His mission to bridge the gap between cutting-edge biotech and accessible health solutions has made him a trailblazer in the field of longevity.Our conversation dives deep into the 12 hallmarks of aging, a revolutionary framework for understanding the biological mechanisms behind the aging process. We also explore actionable lifestyle changes and the synergistic role of nutrition, supplements, and mindfulness in enhancing healthspan and lifespan. From the potential of senescent cell management to the transformative power of personalized health strategies, Chris provides valuable insights for anyone seeking to live a longer, healthier, and more vibrant life. Tune in to uncover the secrets to slowing aging and unlocking your full potential.Looking to discover your science and optimize your life?APPLY FOR HEALTH OPTIMIZATION COACHINGhttps://coaching.knowyourphysio.org/Links Mentioned in Today's Episode:Click HERE to save on BiOptimizers MagnesiumKey Points From This Episode: Health transformation through adversity [00:01:22]Health transformation through adversity [00:05:06]Defining aging at the cellular level [00:09:41]Novos Longevity Diet Optimization [00:12:29]Nutrient inadequacies in modern diets [00:17:04]Testing for vitamin levels [00:20:29]Iron levels and health risks [00:24:51]12 hallmarks of aging [00:29:22]Cellular senescence and longevity [00:31:51]Fasting mimetics and longevity [00:35:54]Trace doses of lithium benefits [00:39:44]Telomere shortening and lifespan [00:45:10]Stem cell exhaustion and aging [00:48:17]Microbiome dysbiosis and health [00:51:31]Synergistic effects of formulas [00:56:48]Lifestyle strategies affecting aging [01:03:12]Nervous system's impact on supplements [01:06:07]Longevity accessibility for everyone [01:10:34]Slowing down aging [01:12:17] SlowMyAgeWebsiteNovos LabsWebsiteNovos Life AppFree mobile app available on iOS and Android, featuring a biological age test, personalized lifestyle guidance, and integrated LLM (AI-powered guidance).PeopleChris MirabileLinkedIn ProfileInstagram (@slowmyage)Andrés PreschelLinkedIn ProfileInstagram (@andrespreschel)Twitter (@andrespreschel)Dan BuettnerWikipediaBluSupport the show
In this week's episode we'll learn more about how clonal hematopoiesis affects prognosis in patients with telomere biology disorders, consider recently uncovered molecular subtypes of extracutaneous juvenile xanthogranulomas, and discuss a clinical trial of the BCMA-CD3 bispecific antibody teclistamab in patients with relapsed/refractory multiple myeloma who have received previous BCMA-targeted therapy.Featured Articles:Clonal landscape and clinical outcomes of telomere biology disorders: somatic rescue and cancer mutationsRecurrent CLTC::SYK fusions and CSF1R mutations in juvenile xanthogranuloma of soft tissueEfficacy and safety of teclistamab in patients with relapsed/refractory multiple myeloma after BCMA-targeting therapies
Willkommen zum wöchentlichen Longevity Briefing! Jede Woche sprechen wir über die neuesten Entwicklungen in der Welt der Healthy Longevity. Wir bringen dir wissenschaftlich fundierte News, neue Therapien, spannende Forschungsergebnisse und vieles mehr. Diese Woche: 1. Kann die Sprache ein Hinweis auf Alzheimer sein? Zum Blogartikel: https://stayoung.de/blog/Alzheimer-Bi... Zur Studie: https://pubmed.ncbi.nlm.nih.gov/38348... 2. Wie lässt sich die Verkürzung der Telomere verhindern und damit der Alterungsprozess bremsen? Zum Blogartikel: https://stayoung.de/blog/Telomerase Zur Studie: https://pubmed.ncbi.nlm.nih.gov/39275... 3. Die biochemischen Gründe, warum viszerales Fett so gefährlich ist! Zum Blogartikel: https://stayoung.de/blog/Viszeralfett Zur Studie: https://onlinelibrary.wiley.com/doi/f... Bonus-Tipp: Melde dich jetzt kostenlos zu unserem Longevity Briefing als Newsletter an und erhalte den kostenlosen Ratgeber zur Hormonersatztherapie: https://link.stayoung.de/Ratgeber-HET
Elizabeth Blackburn, Ph.D., examines the relationship between telomeres, cellular aging, and metabolic health, highlighting how telomere regulation differs between insulin-sensitive and insulin-resistant individuals. She discusses the effects of environmental factors—like glucose levels, stress hormones, and drugs—on telomere maintenance, which can disrupt cellular coordination and contribute to age-related diseases. Blackburn also shares insights from studies on hibernating lemurs, indicating that while their telomere health remains stable during metabolic slowdowns, it declines upon reactivation. Ultimately, she suggests that telomere maintenance could serve as a valuable biomarker for early signs of metabolic dysfunction, informing strategies for long-term health and resilience. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39944]
Elizabeth Blackburn, Ph.D., examines the relationship between telomeres, cellular aging, and metabolic health, highlighting how telomere regulation differs between insulin-sensitive and insulin-resistant individuals. She discusses the effects of environmental factors—like glucose levels, stress hormones, and drugs—on telomere maintenance, which can disrupt cellular coordination and contribute to age-related diseases. Blackburn also shares insights from studies on hibernating lemurs, indicating that while their telomere health remains stable during metabolic slowdowns, it declines upon reactivation. Ultimately, she suggests that telomere maintenance could serve as a valuable biomarker for early signs of metabolic dysfunction, informing strategies for long-term health and resilience. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39944]
Elizabeth Blackburn, Ph.D., examines the relationship between telomeres, cellular aging, and metabolic health, highlighting how telomere regulation differs between insulin-sensitive and insulin-resistant individuals. She discusses the effects of environmental factors—like glucose levels, stress hormones, and drugs—on telomere maintenance, which can disrupt cellular coordination and contribute to age-related diseases. Blackburn also shares insights from studies on hibernating lemurs, indicating that while their telomere health remains stable during metabolic slowdowns, it declines upon reactivation. Ultimately, she suggests that telomere maintenance could serve as a valuable biomarker for early signs of metabolic dysfunction, informing strategies for long-term health and resilience. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39944]
Elizabeth Blackburn, Ph.D., examines the relationship between telomeres, cellular aging, and metabolic health, highlighting how telomere regulation differs between insulin-sensitive and insulin-resistant individuals. She discusses the effects of environmental factors—like glucose levels, stress hormones, and drugs—on telomere maintenance, which can disrupt cellular coordination and contribute to age-related diseases. Blackburn also shares insights from studies on hibernating lemurs, indicating that while their telomere health remains stable during metabolic slowdowns, it declines upon reactivation. Ultimately, she suggests that telomere maintenance could serve as a valuable biomarker for early signs of metabolic dysfunction, informing strategies for long-term health and resilience. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39944]
Elizabeth Blackburn, Ph.D., examines the relationship between telomeres, cellular aging, and metabolic health, highlighting how telomere regulation differs between insulin-sensitive and insulin-resistant individuals. She discusses the effects of environmental factors—like glucose levels, stress hormones, and drugs—on telomere maintenance, which can disrupt cellular coordination and contribute to age-related diseases. Blackburn also shares insights from studies on hibernating lemurs, indicating that while their telomere health remains stable during metabolic slowdowns, it declines upon reactivation. Ultimately, she suggests that telomere maintenance could serve as a valuable biomarker for early signs of metabolic dysfunction, informing strategies for long-term health and resilience. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39944]
Elizabeth Blackburn, Ph.D., examines the relationship between telomeres, cellular aging, and metabolic health, highlighting how telomere regulation differs between insulin-sensitive and insulin-resistant individuals. She discusses the effects of environmental factors—like glucose levels, stress hormones, and drugs—on telomere maintenance, which can disrupt cellular coordination and contribute to age-related diseases. Blackburn also shares insights from studies on hibernating lemurs, indicating that while their telomere health remains stable during metabolic slowdowns, it declines upon reactivation. Ultimately, she suggests that telomere maintenance could serve as a valuable biomarker for early signs of metabolic dysfunction, informing strategies for long-term health and resilience. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39944]
Elizabeth Blackburn, Ph.D., examines the relationship between telomeres, cellular aging, and metabolic health, highlighting how telomere regulation differs between insulin-sensitive and insulin-resistant individuals. She discusses the effects of environmental factors—like glucose levels, stress hormones, and drugs—on telomere maintenance, which can disrupt cellular coordination and contribute to age-related diseases. Blackburn also shares insights from studies on hibernating lemurs, indicating that while their telomere health remains stable during metabolic slowdowns, it declines upon reactivation. Ultimately, she suggests that telomere maintenance could serve as a valuable biomarker for early signs of metabolic dysfunction, informing strategies for long-term health and resilience. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39944]
Women drink less... if you ask them to visualize alcohol? Also, the yucky trick gossipers use to make you think they're kind — and why iron in red meat may be causing cancer (in your bottom).
Willkommen zum wöchentlichen Longevity Briefing! Jede Woche sprechen wir über die neuesten Entwicklungen in der Welt der Healthy Longevity. Wir bringen dir wissenschaftlich fundierte News, neue Therapien, spannende Forschungsergebnisse und vieles mehr. Diese Woche: 1. Kann Sprache ein Hinweis auf Alzheimer sein? Zum Blogartikel: https://stayoung.de/blog/Alzheimer-Biomarker Zur Studie: pubmed.ncbi.nlm.nih.gov/38348772/ 2. Wie lässt sich die Verkürzung der Telomere verhindern? Zum Blogartikel: https://stayoung.de/blog/Telomerase Zur Studie: pubmed.ncbi.nlm.nih.gov/39275278/ 3. Die biochemischen Gründe, warum Viszeralfett so gefährlich ist! Zum Blogartikel: https://stayoung.de/blog/Viszeralfett Zur Studie: onlinelibrary.wiley.com/doi/full/10.1111/acel.14367 Bonus-Tipp: Melde dich jetzt kostenlos zu unserem Longevity Briefing als Newsletter an und erhalte den kostenlosen Ratgeber zur Hormonersatztherapie: https://link.stayoung.de/Ratgeber-HET
Today, we're checking in on the elections, we'll take a look at the "Click-To-Cancel" law, how Grindr is using AI as your new wingman, and we ask if we've reached peak human lifespan. This week we're joined by host of The Political Orphanage, Andrew Heaton, as well as the host of Betches Brides, Selena Coppock!——Thank you to this week's sponsors:Calm - Stress less, sleep more, and live better with Calm. For listeners of our show, Calm is offering an exclusive offer of 40% off a Calm Premium Subscription at calm.com/FAKETHENATION. Rocket Money - Use this link or go to rocketmoney.com/fakethenation to stop paying hundreds of dollars on subscription scams. Start cancelling today!——Rate Fake The Nation 5-stars on Apple Podcasts and leave us a review!Follow Negin Farsad on TwitterEmail Negin fakethenation@headgum.comSupport her Patreon ——Host - Negin Farsad——Producer - Andrew McGuire——Theme Music - Gaby AlterAdvertise on Fake The Nation via gumball.fmSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
On today's episode of The Wholesome Fertility Podcast, I speak to longevity expert Leslie Kenny. @lesliesnewprime Leslie shares her personal journey of overcoming autoimmune diseases and infertility through patient empowerment and alternative therapies. She emphasizes the importance of partnering with doctors and exploring alternative treatments that resonate with individuals. Leslie's story highlights the power of lifestyle changes, such as an anti-inflammatory diet and the use of anti-aging molecules like spermidine in improving health and reversing the aging process. Our conversation covers the topic of spermidine and its role in healthy aging. Spermidine is a compound found in our diet and produced by our gut biome. It is correlated with healthy lifespan and can be obtained from plants and fermented foods. Our conversation also touches on gluten-free options for spermidine, the importance of fiber in the diet, and the potential benefits of systemic enzymes. Leslie also shared her personal experience with hypothyroidism and the importance of finding a doctor who will help you uncover solutions for your reproductive health. Podcast Takeaways: Partnering with doctors and exploring alternative treatments can empower patients to take control of their health. Lifestyle changes, such as an anti-inflammatory diet, can have a significant impact on autoimmune diseases and overall health. Anti-aging molecules like spermidine and rapamycin have the potential to slow down the aging process and improve fertility. Maintaining a balanced hormonal system is crucial for reproductive health and overall well-being. Spermidine can promote cell renewal and recycling. Spermidine is correlated with healthy lifespan and can be obtained from plants and fermented foods. Fiber is important for the gut biome to produce spermidine. Finding a doctor who believes in you and is willing to explore your symptoms is crucial. Guest Bio: Leslie is a longevity expert, and co-founder of the prestigious Oxford Longevity Project, a non-profit that brings scientists together to discuss breakthroughs around the science of ageing and autophagy, which is our body's natural cell recycling system. www.oxfordhealthspan.com - Use coupon code WHOLESOMELOTUS for 15% off all items! https://www.instagram.com/lesliesnewprime/ https://oxfordlongevityproject.org Learn more about my new book “The Way of Fertility” here: https://www.michelleoravitz.com/thewayoffertility For more information about Michelle, visit: www.michelleoravitz.com The Wholesome FertilityFacebook group is where you can find free resources and support: https://www.facebook.com/groups/2149554308396504/ Instagram: @thewholesomelotusfertility Facebook: https://www.facebook.com/thewholesomelotus/ Transcript: Michelle (00:00) Welcome to the podcast Leslie. Leslie Kenny Oxford Healthspan (00:02) Thanks so much for having me, Michelle. It's a pleasure. Michelle (00:05) So I would love for you to share your story of how you got into the work that you do today. And I know that you're very passionate. We just had a little pre -talk and I'm very excited to get started. Leslie Kenny Oxford Healthspan (00:14) You Well, my story is one of patient empowerment, just like you. And it started, as it can with many women, with a fertility quest. So in my mid to late 30s, I really wanted to have a baby and found that I was having problems. So started with IUI, did three of those, didn't work, and then moved on to IVF. And it was as I was doing my fifth IVF round with donor eggs, I might add, and being mixed race, I'll tell you, it's not easy to find a donor, you know? And it was a high stakes game, as it were. And right before embryo transfer, I began to notice pain in my hands. I was having trouble. Michelle (00:54) Mm Leslie Kenny Oxford Healthspan (01:08) using scissors, turning doorknobs, turning faucets. And I just thought, strange, I think this is probably what arthritis feels like. I better just have it checked out since obviously I want this IVF with donor eggs to go perfectly. And I went to the doctor, she ran some tests. I thought, you know, they'd say, you know, it's something, have steroids do something that I'd heard of before. And instead she called me and asked me to have a meeting with her in her office. Michelle (01:17) Mm Leslie Kenny Oxford Healthspan (01:38) and always a bad sign, right? If they can't explain it to you over the phone, and if it's not the nurse telling you, there's nothing to worry about. So I went and talked to her and she said, you do have arthritis, it's rheumatoid arthritis. This is where your body is attacking your joints. And here are some pre -filled syringes that you can inject into your belly, they're immune suppressants to basically Michelle (01:40) Yeah. Leslie Kenny Oxford Healthspan (02:08) halt your immune system from attacking your body. And, and I immediately said, Hmm, don't I want my immune system to be strong? Like, don't I need that? And she said, well, normally you would, but in this case, it looks like your body is fighting cancer, except you're trying to destroy your own tissues. So I thought, okay, well, fine. Got the drugs. these are tiny diabetic needles. It'll be okay. And then she said, but you also have something else. You have lupus. And that I'd never heard of. It was almost as if she'd said, you you have funny tree disease or something. It just made no sense to me. I didn't know what it was, had never heard of it. And I said, what's that? And she said, another autoimmune disease. And I said, okay, so what's the prescription for that? And she said, unfortunately, there isn't a prescription for that. There's really nothing that we have right now to treat it. And you will slowly and progressively get worse. And I said, this is really not a good time for me to have this happen because I'm doing my fifth IVF with donor eggs. I'm waiting for embryo transfer. This is a terrible time. Can't we do something? something else, anything else? Is there anything I can do? No, there's nothing you can do. Like, could I do my diet, my sleep? No, there's nothing you can do. Well, but what about this round? You know, I've done a lot to tee this up and a lot of money has gone into this. As you probably know, I've put in over a hundred thousand US dollars at this point in time into all of these treatments. And she said, I wouldn't do it. Don't do it. you have a good five years left. And I thought, okay, well, that's a big statement to make. And I was so gobsmacked by it. Michelle (04:08) That's crazy. Wait, wait, She was saying you have five years left to live? Is that what she was saying? Leslie Kenny Oxford Healthspan (04:16) That's how I interpreted it. That's how I interpreted that if I, if this was successful, if this round was successful, I would only be able to parent this child for five years or four years, I guess, as it were. And I, it was a lot to process. you know, if you're a patient and you're told you have one thing that's a lot to take on, you know, and then you're thinking about. the treatment protocol and the things you have to do. And I think already, if it's not a tablet to swallow, but you're injecting yourself, that's another big thing to take on board. Then an illness that you've never heard of before where they say there's no treatment, there's no cure, and then she says five years left. I'm thinking in the back of my mind, thinking, have this, I want to become a mother. I have this. cycle I have to go through, we're going to embryo transfer. My uterus has to be in good shape. What are you doing? What are you saying? How does this impact that? Because I've got acupunctures lined up for embryo transfer, right, before and after. And so I did have at least the presence of mind to say to her, can I, well, could this be a false positive? She said, no, we've done multiple types of tests. Michelle (05:11) Yeah. Leslie Kenny Oxford Healthspan (05:35) and they all come back consistently indicating that you have these diseases. So then I said, can I test again? And she said, she shrugged her shoulders and said, sure, it's your insurance. So I vowed then and there that I would test again. And in the meantime, I would do everything possible. didn't matter what it was, whether it was my in uterine massage, which I did, or visualization, which I did. Michelle (06:00) Mm -hmm. Leslie Kenny Oxford Healthspan (06:05) or trauma work, which I did, or, you know, new therapy, intravenous immunoglobulin transfusions, which I did, an anti-inflammatory diet. I was gonna do it all. I was gonna throw the kitchen sink at it. And any woman who is trying to get pregnant knows exactly where I was and that feeling of, I've gotta make this happen. And I will just pull out all the stops. We're doing a full court press, right? And... And so I did all those things and I came back within six months for a regular sort of review with your doctor. She opened the folder and she clearly not looked at the results ahead of time. And she said, well, look at that. You, don't have lupus and you don't have RA. And I said, would you like to know what I did? And she said, no, that's okay. Michelle (06:54) What? Leslie Kenny Oxford Healthspan (07:04) And I said, well, that is, you know, that's pretty, that's pretty groundbreaking, right? Michelle (07:11) Yeah, Leslie Kenny Oxford Healthspan (07:12) so in any event, I was so, I was so shocked by all of this and, really for me, the penny dropped that doctors don't know everything that we treat them as if they must, that they are the Oracle and that they are the, the guide to whom we can outsource our health problems. Michelle (07:23) Mm Leslie Kenny Oxford Healthspan (07:35) But in fact, we have to work in partnership with them. And sometimes they're not willing for insurance or liability reasons to talk about or consider alternative therapies that might work. But we patients have the opportunity to explore those things that resonate with us that might have a meaningful impact. so my journey has really begun Michelle (07:38) Yes. Mm Leslie Kenny Oxford Healthspan (08:04) as a patient advocate, really telling other women, you have more power than you think to move the needle on your health. And as a matter of fact, the things that you do might even be more important than what happens when you go to your acute care doctor, right? When you go into the doctor's office or into a hospital. And it has then... taken me on a journey all the way to Oxford, England, where I ended up meeting a wonderful group of scientists here, a number of whom I helped fundraise for their companies for, all in the regenerative medicine space, and some of whom I've worked on longevity, healthy longevity advocacy. other scientists whom I've worked on to bring an interesting anti -aging molecule called spermidine to market. So those are the... Michelle (09:04) Yes. Is that, that's, that comes from Leslie Kenny Oxford Healthspan (09:10) We can get it from wheat germ. We can get it from mushrooms. can get it from a huge variety of foods that are all plants. Essentially, if you want spermidine, it's almost exclusively in plants. only animal source is chicken liver, which is ironic because, of course, I remember my mother saying, you have to eat chicken liver. So moms do know, right? They've got a wisdom. Michelle (09:19) Mm Mm -hmm. Yes. Leslie Kenny Oxford Healthspan (09:36) But it comes from plant sources. We also make it in our tissues. We moms make it in our breast milk. When we give it to our babies, it's there to help them grow. Men, of course, make it in their seminal fluid. is in there because DNA wraps itself around spermidine. And it's very tightly wound. Michelle (10:00) Mm Leslie Kenny Oxford Healthspan (10:04) Normally DNA is wrapped around something called histone bond. It's too big to really fit into semen. And it's also there in semen as an anti -inflammatory because it turns out that when men make sperm, it's a high reactive oxygen species event. Women and men can both make it in our gut biome as well. so those would be the main, the three sources would be from our tissue production. Michelle (10:27) Mm Leslie Kenny Oxford Healthspan (10:33) And that falls, that declines dramatically similar to the decline in production of estradiol, progesterone, testosterone, melatonin as we get older. And then the second area is the microbiome and then third is from our food. Michelle (10:51) So interesting. So let's go back and talk about what, what do you think it was specifically that changed? Like, what do you think happened with your body? Because you came into the doctor and you had all the signs that showed that you had two different autoimmune diseases that she could pick up. And then you changed your diet, you changed your lifestyle. You really went through so much. and of course it's hard sometimes to figure out exactly what specifically, but now that you know what you know, and this is Leslie Kenny Oxford Healthspan (11:03) Yeah. Yum, yum. Michelle (11:21) the work that you're doing. What are some of the things that come to mind? Leslie Kenny Oxford Healthspan (11:22) Hmm. I went on an anti -inflammatory diet. So one of the first things I did was I researched a lot about both of these illnesses and I could see that inflammation was part of the root cause. And I'd heard about a diet called the Zone Anti -inflammatory Diet. This was popular in the early 2000s. And so I did that and that had a high emphasis on omega -3fatty acids. on extra virgin olive oil. These are anti -inflammatories. It had a high emphasis on plants. And so my diet changed dramatically from more meat and charcuterie, sort of salami, these types of things over to plants. I also eliminated things which were known to be inflammatory triggers for me. So I had an allergy test done. I could see that dairy was a problem, gluten was a problem, eggs happened to be a problem, which was a shame because I loved eggs. But we can't eat them every day and think the body won't notice. We have to kind of mix it up and have a diverse diet. So I essentially removed the inflammatory triggers to the immune system. I added in things that were naturally anti -inflammatory, like the omega -3s. And at the same time, when I did the intravenous immunoglobulin, Michelle (12:44) you Leslie Kenny Oxford Healthspan (12:50) I reset my immune system and there were studies in, there were small groups of patients with both rheumatoid arthritis and lupus who had done IVIG already in 2004 when I was diagnosed and I could see it work for them and I sort of felt like I have nothing to lose. It's kind of this or I wait for the inevitable. And I did have people tell me, don't do the IVIG, because this was the time of mad cow disease. And people were quite concerned about prions, these proteins in blood plasma. And they were worried that you might be able to get that or hepatitis C. These were things that had been transmitted through transfusion products previously. But I still felt that, what, five years? Michelle (13:25) Mm Leslie Kenny Oxford Healthspan (13:49) I have nothing to lose. So I'm so glad that I did do that. know that everyone has to weigh up the risk -benefit analysis of any new treatment and their own situation. But for me, that was a decision that I made, and I'm so glad I did, because I spent 20, my insurance company spent $24 ,000 US on two transfusions, eight hours in total. And I have Michelle (13:52) Mm Leslie Kenny Oxford Healthspan (14:19) Going into remission meant that I have foregone over a million US dollars worth of immune suppressing drugs or chemo drugs because often we autoimmune patients get moved on to methotrexate, which is a chemo drug. I've not had to do any of those over these 20 years. And of course, I also don't live in pain and I don't. Michelle (14:29) Mm Right. Leslie Kenny Oxford Healthspan (14:45) live in fear of because I'm suppressing my immune system, I have to avoid social situations where people might have a cold and give it to me and compromise my immune system. So it was a fantastic outcome for me. It's not one I think a lot of people hear about, but I think they should. Michelle (15:06) for sure. I mean, it's good to hear everything. And I agree with you that everybody has to really assess their own personal situation. I think, I believe in the innate intuition that's kind of like our body's intelligence speaking to us, just like it does when we have an allergy or we feel some things off when we eat something. So I think that that is a really important component to that. And it's the thing that spoke to you when you were at your doctor's office, because it, Leslie Kenny Oxford Healthspan (15:20) Yeah, agreed. Yeah. Michelle (15:36) You could have just said, okay, I'm going to completely bypass any questions that I have and fully just accept everything that I'm given. But something inside of you said, wait, hold up. Let me just do this again. Let me look at this. me think about this. So I really believe in that. think that is so important and important for people to hear because so often we do that. We bypass our own internal judgment and knowing. You said something important is partnering up with your provider so that it's not an all or nothing. Of course you're going to utilize and you did, you got benefit from getting those tests because that woke you up to doing so many new and amazing things in your own life and implementing a better diet and so on. As far as Omega -3 goes, this is just something that I've been hearing of late. that some of the supplements go rancid and that it makes it worse. it, have you heard about that? Leslie Kenny Oxford Healthspan (16:36) Yeah, I've heard that. Yeah, and apparently what you need to do is take this supplement and put it into the freezer. And if it gets cloudy, that is what I've heard is that then that's not good. It's supposed to remain clear throughout. I'm not an omega -3 fatty acid expert. I have lived for a number of years, very nearby one here in Oxford, Professor John Stein. Michelle (16:45) Mm Leslie Kenny Oxford Healthspan (17:05) who's done a lot of the research on mental health issues and omega -3s and how important they are for brain health. But yeah, I think, you know, get it from your diet first and foremost. Fatty fish is a great source, right? Yeah. Salmon, if we, you haven't already eaten all of it. Yeah. Michelle (17:18) Right. Good fish. Yeah. Wild caught, yeah. Yeah, I know. It's so crazy. Well, also just the mercury in some of the salmon, you know, the chemicals, but wild caught, I always say just. Leslie Kenny Oxford Healthspan (17:33) Yeah, wild caught. Yeah. And also anchovies, mackerel, sardines, right? The small fish are a really good source of omega -3 fatty acids. And those tend not to have the mercury. Obviously, if we're trying to get pregnant, mercury, definitely not your friend. So yeah. Michelle (17:38) Sardines, yeah. Yeah. Yeah, for sure. I always say, you know, if you're not going to have it when you're pregnant and if you don't have it when you're trying to get pregnant because tuna, for example, they always caution not to have that because of the high mercury, but you don't want that in your system if you're trying to conceive. So for I was very intrigued by your story and I was also intrigued by what you do because when you think about egg quality, sperm quality and really reproduction, Leslie Kenny Oxford Healthspan (18:02) Yum. Yum. Hmm. Michelle (18:18) you think anti -aging, that's like ultimately anti -aging in a nutshell. Like that's really what I do for people that I work with. And it benefits me because I'm like, okay, you know, I'm just going to apply a lot of these things as I learn. it definitely, but that's what it is. It's anti -aging. Like I'm big on meditation, which has also been shown take our clocks back, but food and diet and certain supplements, Leslie Kenny Oxford Healthspan (18:20) Mm -hmm. 100%. Yeah. Yeah. Yeah. Michelle (18:46) can actually shift and slow down your aging or sometimes even like reverse your biological clock. And I know you're the expert in this specific topic. So I'd love for you to talk about that and what has been discovered and seen in this subject. Leslie Kenny Oxford Healthspan (18:57) Sure. So when we are at our peak health is when we are reproductively capable. And we visually know this when we go out and we see a woman with glossy long hair, with long eyelashes, with healthy radiant skin, of healthy body weight, we know that that is someone who is who is really attractive and why are they attractive? Because they are at their reproductive height. And interestingly, all of the things I have described are also linked with your spermidine levels. And so that's quite interesting. But also, your hormones are in perfect balance when you can reproduce and that includes not just the usual female sex hormones, Michelle (19:36) Mm Mmm. Leslie Kenny Oxford Healthspan (20:01) but also your thyroid hormones. So I'm also a Hashimoto's survivor as well. And so I'm a hypothyroid patient and that is also really important. So it's got to be in perfect balance then. And one of the things that happens with some of these anti -aging molecules is that they extend fertility. Michelle (20:07) Mm Mm Leslie Kenny Oxford Healthspan (20:28) partly by reversing your age, but they will start the reproductive cycle back up for some people. And it kind of depends how far away from menopause you are. But we've certainly had clients who've said, what happened? I've been in menopause for two years and I've gotten my cycle back. And... On the one hand, want to say, congratulations, that's great. But they're thinking, this means I can't wear white trousers now, right? And I thought I was done with the pads and the tampons. So I know it's a little bit of a double -edged sword. We women are often thinking about, how do we get rid of our cycles? But in fact, they are nature's way of saying that we are in peak health and are capable of bringing another life into this world. Michelle (20:55) Hahaha Yeah. Leslie Kenny Oxford Healthspan (21:22) You know, we do have to bear that in mind. Of course, the same is true for men. And we know there's a problem with testosterone declining in young men, whether it's due to endocrine disruptors in our food and our water supply, toxins in the air. There is a challenge to men as well. And we do want to see them at their reproductive best in order to be at optimum health, too. And that is also something that these geroprotectors, these senolytic drugs, these anti -aging molecules can do. They seem to restore fertility in men as well as women. Michelle (22:03) Amazing. And so let's break it down for people who have never heard of these molecules and these supplements and spermidine. So take a step by step, like, so that people listening can understand what it is. Leslie Kenny Oxford Healthspan (22:07) Yeah. Sure. OK. Well, first, me just say that there are scientists believe that there are 12 reasons why we get older. And these are known as the hallmarks of aging. And they include things that you and your listeners will have heard of before, things like inflammation, leaky gut, stem cell exhaustion or dysfunction, mitochondrial dysfunction. So, you know, where you have no energy. Telomere shortening. So telomeres are at our in caps and they limit the number of times that we can replicate ourselves. So all of these reasons why we get older, scientists have looked at different molecules that can inhibit those, you know, us going down those pathways. And they have a list of these molecules that inhibit certain numbers of molecules. And the two that do the most are one called rapamycin, which is a bacteria, and the other one is spermidine, which we manufacture ourselves, like I said, in our gut, in our tissues, and also we get from food. But importantly, it is found in both breast milk and in sperm, and it's so necessary for the survival the start and survival of the next generation, that it's also in the endosperm of all plants. So these two molecules, rapamycin and spermidine are kind of the darlings of the anti -aging set. And one of spermidine's superhero powers is that it activates cell renewal and recycling. So if we think about staying in perfect health, one of the first things we want to do is make sure that we can do is every day oven cleaning, right? And the cells do have that function. Maintenance, exactly, exactly. Now, when we're young, it happens naturally and we don't think anything of it, but as we begin to age, that process falters and the cells, the dysfunctional cells, Michelle (24:16) Mm -hmm. It's a maintenance. Leslie Kenny Oxford Healthspan (24:32) which we call senescent cells, they begin to stack up. And the more of these senescent or zombie cells that we have, the less well the other cells function. And I sometimes say that these zombie cells are a bit like your uncle Ted who has too much to drink at a wedding, and he begins to say inappropriate things. Michelle (24:45) Mm you Leslie Kenny Oxford Healthspan (24:56) and do really silly stunts and you just think, okay, we got to get Ted over with pot of coffee in the corner away from everybody else or he's going to ruin the party for everyone else. This is what senescent cells do to you. You have one senescent cell and it begins to leak inflammatory contents to the other cells nearby and zombie -izes them and does the same to the other cells. It's a cascade effect. Michelle (25:09) Mm. Leslie Kenny Oxford Healthspan (25:25) That is what spermidine can actually, one of the things it can help with in particular with immune cells, it can prevent those immune cells, well rather it can rejuvenate senescent immune cells and that is the work that was done at the University of Oxford. Michelle (25:43) That's amazing. you moved there to work with them in the research? Leslie Kenny Oxford Healthspan (25:48) Well, I came here anyway. I came here because my ex, now sadly my ex, but we have two wonderful children together. He was from Oxford and moved here to be closer to his family and still close to them and absolutely fell in love with the town and just the vibe. University towns are definitely my kind of place. Michelle (26:09) Hmm. That's nice. Mm Leslie Kenny Oxford Healthspan (26:18) Just the scientific rigor here in the life sciences, it's phenomenal. It's really impressive. Michelle (26:29) That's amazing. so the two things you're saying are spermidine and rapamycin. and so spermidine is something that you could take from supplements, but not so much rapamycin. Leslie Kenny Oxford Healthspan (26:39) You can't, no, not rapamycin, no. It's not something you're going to find in food. So it was basically isolated on Rapa Nui, which is one of the Eastern islands. And one of the pharmaceutical company, a researcher basically took it back home to the United States and it was later researched and found to do. some really amazing things, one of which is that it can suppress the immune system. And this is important for people who have organ transplants because the tissue match is not perfect and their bodies necessarily want to reject any foreign material in their bodies. So if you give these patients immune suppressants to stop the rejection of the organ, they can live quite nicely with Michelle (27:16) Mm Leslie Kenny Oxford Healthspan (27:33) with that organ and continue in reasonable health, understanding that their immune system has been suppressed. Spermidine, though, of course, it's in our diet. It's something that our gut biome, if it's not been compromised by too much exposure to broad spectrum antibiotics, it can make. And in all of the longevity hotspots of the world, these populations of healthy centenarians, their spermidine levels are high, they're similar to those of people who are in their 50s. And it's correlated with healthy lifespan. So I always recommend that people try to get more plants in their diet because you will get spermidine in your plants. If you can have fermented foods, Michelle (28:12) Mm Mm Leslie Kenny Oxford Healthspan (28:29) If you don't have a problem with histamine load, and some people do for allergy, you know, if they've got allergies, but if you don't have a problem with histamine, then, you know, kimchi, sauerkraut, even things that are long matured like cheese. And a lot of people can say, I'm not allowed cheese because it'll make me gain weight. Well, yes, but there is also some spermatine there. The longer the maturity of the, of the cheese, the more it's been aged, the higher the spermatine content. Michelle (28:45) Mm Leslie Kenny Oxford Healthspan (28:58) Usually these are harder cheeses like a Parmesan or a cheddar. These would be good sources. And then for individuals who need extra, then a supplement makes sense. But I always say, get it first from your food. Please do not rely on a supplement, right? That's not doing, it's a disservice to think that you can just have a bunch of little pills on your plate. Well, at first you're not going to get any satisfaction from it. But the other thing is that we need the fiber in those plants because that fiber, although our bodies don't, don't digest it, the gut biome needs that. And so you, you want to also feed the colonies in your gut biome that can make more spermidine for you. You know, we have these little pharmaceutical factories that make Michelle (29:46) Mm Yeah. Leslie Kenny Oxford Healthspan (29:54) everything from B vitamins and serotonin, one of the happiness hormones, and spermidine. So why waste it? actually in our supplement, the wheat germ derived one, we have a fructo -oleigosaccharide in there, an FOS, can selectively feed the bacteria that make spermidine. And the reason I want it there is because that's also what's in breast milk. In breast milk, you have these fructo -aligosaccharides, you have spermidine, sperminine, another polyamine that actually helps turn good genes on, bad genes off, and then a precursor polyamine called putrescine. So you want some fiber, basically, that's the takeaway. Please, you want the fiber, yeah, exactly, because it's always better to, what do they say? Teach a man to fish, feed him for life, right? Michelle (30:38) With the spermidine. Yeah. Leslie Kenny Oxford Healthspan (30:49) rather than just give him the fish. And that's kind of what we want to do. We want to train your body to make more of it, especially as you get older, because you'll have to eat increasing amounts of plant material to make up the shortfall of your tissue production of spermidine going offline. Michelle (30:57) Right. It's fascinating. So wheat germ is not necessarily gluten -free. For people who are gluten -free, what do they do? Leslie Kenny Oxford Healthspan (31:16) Well, OK, so yes, obviously, this is a problem in particular for autoimmune patients. And I went on the autoimmune paleo diet myself. I got rid of all gluten. I was off all lectins. Gluten is most famous lectin. So I had so many autoimmune patients getting in touch with me who'd heard my story that I actually looked for a plant source high in spermidine that was not a lectin. And I found it in an unusual strain of chlorella. Michelle (31:28) Mm Leslie Kenny Oxford Healthspan (31:45) So I went to Okinawa and had to test 120 different strains, substrains of chlorella to find the single one that had very high expression of spermidine. And we commissioned that to be grown in open -air freshwater ponds that are on land in Okinawa, but next to the ocean, but not in the ocean. Michelle (31:46) Mm wow. It's wild. huh. Leslie Kenny Oxford Healthspan (32:11) And that's what we use in our gluten -free product, which also has Okinawan autumn turmeric and has Okinawan lime peel. So lime peel has another autophagy activator. That's that cell renewal process. This autophagy or cell renewal activator is called nobilitan. And it's also in bergamot, in bergamot, the citrus fruit. Michelle (32:16) Mm -hmm. Mm Mm -hmm. Right. Leslie Kenny Oxford Healthspan (32:38) And that actually, interestingly enough, is an Earl Grey tea. So if you're going to drink a tea, maybe some Earl Grey, you'll get some nobilitan in that. But that formulation was especially made for celiacs and for other autoimmune patients who really wanted the benefits of autophagy but couldn't use the defatted wheat germ version that we had brought to market first. Michelle (32:42) wow. Interesting. Mm Mm Amazing. Let me ask you a question. Have you looked into enzymes, pro proteleic? No, enzymes that are actually systemic enzymes that you have on an empty stomach. like things like wobe enzyme and yeah. And I think that there's another one, it's Nuzheim or there's another pretty well -known company. And I think it's from Europe. Leslie Kenny Oxford Healthspan (33:11) You mean like digestive enzymes or? I've taken wovenzyme. So yeah, wabenzim is German. I took that, gosh, maybe it's been around for decades and it does work. I took that from my, interesting. I took it, I didn't know that. I took it for joint pain. And so this was something that I was taking as a way to try and treat myself for the rheumatoid arthritis. So it didn't, it wasn't enough for that. I think it can help. Michelle (33:40) It was beneficial for thyroid. Yeah, yeah. Yeah. Yeah. Leslie Kenny Oxford Healthspan (33:59) more mild things, but definitely these are of benefit. And having a coach like you, who, you know, a trained practitioner who knows about all of the menu items that could be selected, you have the different tools, right? It's overwhelming as a patient. I mean, even just having my doctor say, just inject this one drug, that was like, whoa, can I get my head around the idea of injecting myself, right? Michelle (34:13) Yeah, like different tools. yeah. Yeah. Leslie Kenny Oxford Healthspan (34:29) So you do need a guide and I think it's great that you've got that knowledge that you can share with your clients. Michelle (34:37) Thank you. also, so for people who are interested, is it mostly the spermidine that you're focused on? Leslie Kenny Oxford Healthspan (34:45) Yes, so basically we are a small all -women company and you know, women -led companies, we get around 2 % of all venture capital funding. We don't have venture capital funding like our competitors. We very much are growing organically and are looking at really focusing on something that we know very well and making the most excellent Michelle (34:49) Mm -hmm. Leslie Kenny Oxford Healthspan (35:13) product on the planet. And for me, with my group of advisors, this has been the right thing to do because we've had so many raw material manufacturers and suppliers come to us telling us, try this spermidine. And when we tested in the lab, we see that it's basically a tiny amount of wheat germ, and it's been cut like a street drug with synthetic spermidine. Michelle (35:15) Awesome. Leslie Kenny Oxford Healthspan (35:42) And the problem with synthetic spermidine is, firstly, OK, I am biased against the synthetic because I watch my mother take the synthetic HRT. I'm so glad I'm on bioidentical HRT. But the synthetic has never been tested for safety or efficacy in humans. So I'm reluctant to bring a product to market that has not been tested. And when it comes to fertility, Michelle (35:43) wow. Mm Mm Leslie Kenny Oxford Healthspan (36:11) We know that in mouse studies where they have used synthetic spermidine, small amounts seem to help. But then when you give just a little bit more, it actually impairs fertility. so with these... Michelle (36:22) wow. That's important. That's really important, you guys, to listen to that because that's huge. Leslie Kenny Oxford Healthspan (36:28) Yeah, that's huge. So the problem is finding the Goldilocks zone. Each of us is bio individual. We have different ethnic difference, genetic differences, age, body shape, height, and metabolism. All of these things mean you want the right amount for you, but we don't know what that right amount is when it comes to synthetic spermidine. With plants, however, it's not a problem. because the body recognizes this, we have co -evolved with plant -derived spermidine for millennia. So when there's too much, the body says, right, we're going to turn this into spermine, which is going to help with turning good genes on, bad genes off with the DNA methylation. But this doesn't happen with the synthetic. I think that on the fertility front, as a woman, I would never make that. Michelle (36:55) Yeah. Leslie Kenny Oxford Healthspan (37:21) I would never go for something that might possibly hurt my fertility. Michelle (37:25) absolutely. Absolutely. I mean, it's a complete waste of time because you're trying to do all these other things and then you're going to take something that's not, that's a risk. and then I was curious, it says you were talking about it you were saying that sometimes they'll find it in certain mushrooms, cordyceps by any chance. Leslie Kenny Oxford Healthspan (37:30) Yeah. Yeah. Yeah. Mmm. it will be in cordyceps. It will be in all mushrooms and the ones that have the highest amount of swirmed in our shiitake, oyster and trumpet, but all mushrooms will have it. And, know, if you, if you don't have a problem with, mushrooms, know, this is fall, it's autumn. This is the right time to, you know, get some mushrooms into your stews and your soups and, Michelle (37:43) Mm -hmm. Mm -hmm. Awesome. Mm -hmm. Leslie Kenny Oxford Healthspan (38:06) It's really, it's so, so good also because it's got vitamin D and we're just coming off of this period where we've soaked up the vitamin D from the sun over the summer, but now we're going into winter and we're gonna get less. So there are so many reasons to get it also a wonderful source of fiber. Michelle (38:16) Yeah. Yeah, amazing. So if people are interested and want to learn more and then also want to look at your products, how can they find you? Leslie Kenny Oxford Healthspan (38:32) They can go to Oxford HealthSpan, like the span of a bridge, it's all one word, .com. And if they're interested in learning more about healthy aging, we do bring breakthrough scientists who talk about things, not just about cell renewal or autophagy, but talk about other things as well. We also have them talk about, say, NAD, things like this. That's at the OxfordLongevityProject .org. Michelle (38:56) Yeah. Mm Leslie Kenny Oxford Healthspan (39:01) And then I have kind of a side hustle helping my girlfriends with gray hair reversal. And that's on Leslie's new prime. Spermadine helps with that as well. It helps with hair health and eyelash and eyebrow health. That is on Leslie's new prime on YouTube. So L -E -S -L -I -E is how I spell my name. Michelle (39:08) nice. Fabulous. Leslie, this was fascinating. I really enjoyed talking to you. And also a key point, you got pregnant naturally at 40. Okay. important thing to mention. And I kept thinking about it as we're talking about, wait, wait, let's go. Let's go talk about that, even though it's kind of the end of the episode. Leslie Kenny Oxford Healthspan (39:34) I did at Yeah. Yeah. Yeah. Well, it's a, it's a happy ending. So, so the fifth IVF with the donor eggs didn't work. As a matter of fact, the embryologist said on embryo transfer, said, I don't know why you didn't use your eggs. Your eggs are better than this younger donor. I was like, You're kidding me because I can't tell you how much I just sacrificed to pay for that. And, but, know, basically fast forward, I adopted a little girl from China. So I became a mom. become parents, you know, mother is a verb. It's not a noun. So that was, that was great. And as I was taking care of her, I still felt very, very tired and I couldn't understand what was going on, why I saw these other moms. Michelle (40:02) wow. Leslie Kenny Oxford Healthspan (40:27) running around with scout troops, planting gardens, walking dogs, five children. You know, why? How do they do it? They're the same age and they have so much more energy. And I just, I did go to Dr. Google. I put in every symptom I had and it came up hypothyroid. So then, The GP here in the UK said, no, you're in the normal range. No problem. I went to a private GP. No, you're normal. I went to a private endocrinologist. No, you're normal. And I just thought, I know I'm not. These doctors keep telling me I'm normal. I know. We patients always, if you do feel like that, follow your intuition, find a doctor who believes you, and we'll run the test. We'll work with you to uncover the mystery. It's like a murder mystery, right? So. Michelle (41:09) Yes. Yes. Leslie Kenny Oxford Healthspan (41:14) So I went on patient forums. Patient forums have been great help. Went there and people said, there is one doctor who will help you and he won't just look at your blood test. A lot of doctors look at thyroid problems and they only look at your blood test, your TSH, your T3, your T4. I went to him and he looked at clinical symptoms and he also ran a cortisol test. And he said that my... Michelle (41:33) Mm Leslie Kenny Oxford Healthspan (41:43) Cortisol was the lowest he had ever seen. It was so bad, he didn't know how I was standing in front of him. And I had classic cold hands, cold feet. Yes, my hair was thinning. I was exhausted. I was breathless as I went upstairs. I was losing the outer third of my eyebrows. These are all clinical symptoms of hypothyroidism. He then said, Michelle (41:50) Wow. Mm Leslie Kenny Oxford Healthspan (42:09) What you need to do is address your adrenals first because of the cortisol problem, and then two weeks after that, take some thyroid. And because I actually do not convert levothyroxine, which is a standard thyroid hormone that most people get, like 60 % of all Americans will get that, but I can't convert it into the bioavailable. Michelle (42:22) Mm Right. Yeah. Leslie Kenny Oxford Healthspan (42:33) thyroid hormone known as T3. And your cell receptors only have receptors for T3, not for levothyroxine. So if you've been taking loads and loads of levothyroxine, you still feel wiped out. You probably are just like me and have a genetic, you're genetically challenged and you can take a test with Genova diagnostics. I think it's called the DIO2 genetic test, D -I -O -2. And Michelle (42:35) Mm Mm Mm -hmm. Mm -hmm. Leslie Kenny Oxford Healthspan (43:01) here in the UK cost about 75 pounds and you then can get T3 prescribed either synthetically or you can do what I do and Hillary Clinton also does. take something, we take a desiccated pig's thyroid. In America there's Armour, There's Armour, there's Urfa, there are a few brands and that within, you know, two to three weeks basically on that Michelle (43:16) Is that armor? Yes, yeah. Leslie Kenny Oxford Healthspan (43:29) Pregnant right away. No idea. Had not even, didn't check if I was ovulating. You remember the days when you're like, you've got a thermometer under your tongue and you're checking, am I ovulating? Could it be now? And all the calendar work that you've got to do when you're trying to get pregnant, none of that. It just happened. And I was so shocked. yeah. So my daughter, Marguerite, was born, you know, Michelle (43:38) Yeah. That is so crazy. Leslie Kenny Oxford Healthspan (43:57) Eight months later, was just one day shy of being premature, so I got her over the premature line. And 10 out of 10 on the Apgar score delivered at age 43. Michelle (44:08) Amazing. mean, that is just incredible. I'm sure, I mean, I'm so excited about this episode because I just feel like it's mind blowing, first of all, just all the different stories. And it also covers things that I feel are really important. advocating for yourself as a patient. I mean, that is huge. And I think a lot of us have been in those kinds of situations. You said something that I was like, wow. That's a quote, find a doctor who believes you. You know, because also getting different opinions is super important and it's a game changer. It'll totally change your whole journey. Leslie Kenny Oxford Healthspan (44:37) Yeah, yeah, yeah. Yeah. Yeah. Well, look what this doctor did for me. So what none of the doctors had realized with those other two autoimmune conditions was that I had my autoimmune, the system, the immune system had not only attacked my joints and my organs, but it had attacked my thyroid. And the way that he could see it was, you know, he could see with. Michelle (45:07) Mm -hmm. Leslie Kenny Oxford Healthspan (45:11) that I had all the clinical symptoms, but with an ultrasound, he could see that I had only one eighth of a thyroid left. I had so little viable thyroid left. There was just nothing of the organ left. yet, because he didn't want to fall in line here in Britain, he was actually hounded by the British Medical Council. Michelle (45:23) Wow, that is so crazy. Leslie Kenny Oxford Healthspan (45:35) Mary Schumann, the thyroid advocate in the United States, who's written a number of thyroid patient handbooks, actually got a campaign together to try to gather signatures. And he had tens of thousands of signatures from grateful patients. But the medical council actually wasn't listening. They wanted their protocol to be followed. And it had to be a blood protocol. Michelle (45:55) It's so crazy to me. Leslie Kenny Oxford Healthspan (46:02) And this is the problem is the blood does not show everything. But of course, we patients get these data points 24 -7.We know if our hair is falling out, if we can't shift the weight, if we can't walk upstairs without getting winded, if we've got cold hands and cold feet, our partners know because they tell us, God, you're freezing. What's going on? So we need. Michelle (46:06) you Yeah. Mm Yeah, yeah, totally, totally. Leslie Kenny Oxford Healthspan (46:30) Our partners know it. If, if you happen to be sleeping with a doctor, maybe he can be a prescribed for you and he'll believe it because of the cold feet. but otherwise, you know, you have to rely on your powers of persuasion to find a doctor who's willing to go the extra mile with you and get curious. I only ask that I just find a doctor who's willing to get curious with you. Michelle (46:35) Right? Yeah. Yeah, I love that. I love that. Well, I mean, I could talk to you for longer than we have. But let's say this is amazing information, like really, really, truly amazing. And I love your story. And I love the way you truly believed in yourself. And that's something that I want to tell everybody who's listening, just believe in yourself because you know, and you know what? The body is so forgiving, way more forgiving than we give it credit for. It's just a matter of Leslie Kenny Oxford Healthspan (47:21) 100%. Michelle (47:22) figuring out like what is it exactly that it needs, like just figuring it out, its own way of communication. So thank you so much, Leslie, for coming on today. Leslie Kenny Oxford Healthspan (47:28) Yeah. absolutely. Thank you for having me on. really appreciate it. It was lovely chatting with you, really fun. And keep going with your amazing work. Women need guides they can trust like you, who are willing to take the extra time to get curious and share the knowledge that you've gained over the years and the hard work you put in to get pregnant yourself, right? Michelle (47:57) Thank you so much.
n this episode, CJ dives deep into the powerful concept of neuroplasticity, the brain's ability to rewire itself and adapt through learning and experience. Neuroplasticity is not just a buzzword; it's a fundamental aspect of how we can improve cognitive performance, longevity, and overall health. CJ ties together biohacking, natural methods, and cutting-edge scientific discoveries to show how we can boost brain function, stave off aging, and optimize our physical health.Key Topics Covered:Cognitive Hacking: Improving focus, memory, creativity, and decision-making are all linked to keeping our brains flexible and sharp. CJ emphasizes that cognitive function directly impacts longevity, and brain health is a gateway to a longer, healthier life.Nootropics: CJ explores nootropics like Modafinil and its refined version, Armodafinil, as smart drugs that boost brain performance, alongside natural alternatives like cold exposure and breathing techniques, such as the Wim Hof Method.Natural Cognitive Boosters: From blueberries and dark leafy greens to mindfulness meditation, CJ offers accessible ways to keep your brain sharp without relying on synthetic compounds.Stem Cells and Aging: CJ breaks down the types of stem cells (e.g., Mesenchymal and Hematopoietic) and how they play a key role in repairing tissue and boosting the immune system. He suggests simple lifestyle changes like resistance training and intermittent fasting to naturally promote stem cell health.Muscle Growth and Anti-Aging: Maintaining muscle mass is crucial as we age. Strength training and anti-inflammatory diets rich in omega-3s can help slow down muscle degradation, while exploring the potential of follistatin for future anti-aging breakthroughs.Telomeres and Longevity: Stress management is essential for protecting telomeres, the protective caps on our DNA that shorten as we age. Practices like meditation, yoga, and spending time in nature can reduce stress and support longevity.Key Takeaways:Neuroplasticity is vital for keeping our brains flexible, and by learning new skills and habits, we keep our cognitive function sharp as we age.Natural cognitive enhancers like sleep, cold exposure, and mindfulness can be as effective as nootropics in boosting brain performance.Stem cell health can be maintained through regular exercise and intermittent fasting, which helps to boost immune function and tissue repair.Muscle maintenance is crucial for longevity; resistance training and anti-inflammatory foods can slow muscle loss and reduce inflammation.Telomere health is directly linked to stress. Reducing chronic stress through mindful practices helps protect your DNA and slow aging.5 Things You Can Start Doing Today:Practice mindfulness meditation to boost creativity, reduce stress, and support brain function.Incorporate berries and leafy greens into your diet to enhance memory and brain health.Start intermittent fasting to regenerate stem cells and improve longevity.Do strength training to maintain muscle mass and slow down the aging process.Prioritize sleep to enhance cognitive function and protect your overall health.Stay curious, and embrace a balanced approach to biohacking for a healthier, longer life!
"If you lose those inflammatory foods, you reduce autoimmune and gut dysbiosis, which is key to improving overall health." - Edward Park In this episode of Fall In Love with Fitness, The discussion begins with Edward Park sharing the personal story of his father's illness that ignited his profound interest in telomeres and longevity. He explains how telomeres, the protective caps at the ends of chromosomes, play a crucial role in cellular aging and how specific activators can maintain telomere length, thus potentially extending healthspan. Edward Park is a distinguished physician with extensive 20 years of experience in anti-aging and regenerative medicine. Edward has been a pioneer in advocating for innovative treatments that enhance longevity. Throughout the conversation, Edward explores the various dimensions of aging, including stem cell depletion, self-suicide of cells, and the role of environmental factors. He further dives into practical insights on diet, exercise, and the importance of managing stress for a healthier lifestyle. This episode not only provides a comprehensive understanding of cutting-edge anti-aging science but also emphasizes the importance of a robust immune system and maintaining a positive mindset for overall well-being! Topics Covered: 0:03 - The Impact of Telomeres and Stem Cells on Aging 8:08 - Diet, Mindset, and Immune Health in Modern Society 16:03 - The Importance of Sleep and Telomerase Activation for Longevity 19:37 - Transformative Effects of Telomere Activation on Health and Aging 23:28 - Exosomes vs PRP and Stem Cells for Regenerative Medicine 30:32 - Marrying Spirituality and Science in Healing Practices Key Takeaways: Telomerase Activation: Edward emphasizes that the use of telomerase activators can significantly slow down the aging process by maintaining telomere length and supporting stem cell health. Impact of Diet and Environment: The importance of a clean and balanced diet, free from inflammatory agents, alongside the contribution of a positive environment to one's health, is crucial. Significance of Mindset: A positive and grateful mindset is fundamental to enhancing immune function and longevity, as thoughts and emotions heavily influence physiological well-being. Efficacy of Exosomes: Edward shares the superior benefits of using exosomes for cellular repair and regeneration compared to traditional methods like PRP, emphasizing their non-inflammatory properties. Holistic Approach to Health: Incorporating aspects like restful sleep, stress management, and joyful living can profoundly impact one's health and longevity. Connect with Edward Park: Facebook https://www.facebook.com/RechargeBiomedical Website rechargebiomedical.com YouTube Exosome Lectures - YouTube Connect with Sherry Shaban: Book a Food Freedom Strategy Call: https://calendly.com/sherryshaban/makepeacewithfood Get Your Free Food Freedom Workbook: https://www.makepeacewithfood.com Download HIIT Decks App Now!: http://www.hiitdecks.com Fall In Love With Fitness Podcast https://www.fallinlovewithfitness.com Do you feel like you do really well during the day, but then sabotage all your efforts at night and one weekend eating all the things you promised to avoid? Join our FREE 4-DAY Fat Loss 101 Masterclass this September 23-26! Learn how to stop self-sabotaging and unwanted eating habits by regulating your nervous system so you turn your body into a fat-burning machine without dieting or excessive exercise. Register now at https://www.sherryshaban.com/fatloss101 Sherry
Hyperbaric oxygen chambers have been around for years but they have recently begun to be used for medical treatments and longevity. Cloe Bohbot, owner of Oxynergy2, shares how she began using hyperbaric oxygen therapy (hbot) to help people recover from their illnesses quicker and more effectively.We discuss how important oxygen is at the cellular level and how the human body uses oxygen to help keep itself healthy. Cloe shares how HBOT is also a great tool for improving longevity and quality of life as we age. Learn more at www.oxynergy2.com and follow on Instagram.com/oxynergy2 Visit ConfidenceThroughHealth.com to find discounts to some of our favorite products.Follow me via All In Health and Wellness on Facebook or Instagram.Find my books on Amazon: No More Sugar Coating: Finding Your Happiness in a Crowded World and Confidence Through Health: Live the Healthy Lifestyle God DesignedProduction credit: Social Media Cowboys
BUFFALO, NY- August 5, 2024 – A new #research paper was #published on the #cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 14, entitled, “Association between osteoporosis and the rate of telomere shortening.” A shorter leukocyte telomere length (LTL) is reported to be associated with age-related diseases, including osteoporosis. Many studies have tried identifying the association between LTL and osteoporosis, although it remains controversial. In this current study, researchers Myung-Hoon Han , Hyuk Sung Kwon, Mina Hwang, Hyun-Hee Park, Jee Hyang Jeong, Kyung Won Park, Eun-Joo Kim, Soo Jin Yoon, Bora Yoon, Jae-Won Jang, Jin Yong Hong, Seong Hye Choi, and Seong-Ho Koh from Hanyang University Guri Hospital, Hanyang University Graduate School of Biomedical Science and Engineering, Ewha Womans University College of Medicine, Dong-A University College of Medicine, Pusan National University Hospital, Eulji University Hospital, Eulji University School of Medicine, Konyang University College of Medicine, Kangwon National University School of Medicine, Yonsei University Wonju College of Medicine, and Inha University College of Medicine, aimed to determine whether osteoporosis is independently associated with LTL shortening in a prospective longitudinal cohort. “We compared the LTL values for each participant at baseline and over a 2-year follow-up period.” Multivariable linear regression was conducted to identify whether osteoporosis is independently associated with the rate of telomere shortening. A total of 233 subjects (from 55 to 88 years) from the KBASE cohort were finally enrolled in the study. Multivariable linear regression analysis indicated that only osteoporosis was independently associated with rapid LTL shortening over 2 years (B, -8.08; p = 0.038). “We sought to identify an association between osteoporosis and LTL shortening in an independent prospective cohort.” DOI - https://doi.org/10.18632/aging.206034 Corresponding authors - Seong Hye Choi - seonghye@inha.ac.kr, and Seong-Ho Koh - ksh213@hanyang.ac.kr Video short - https://www.youtube.com/watch?v=SGdkAYfA4-A Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206034 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, leukocyte telomere length, osteoporosis, interleukin-6, prospective cohort About Aging-US The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
Hier gelangst du zum ganzen Video: [YouTube-Link]Lade dir den Zuckercode jetzt kostenfrei herunter: [Skool-Link]Inhaltsverzeichnis: 00:00: Intro 00:30: Diskussionsthema: Der Zuckercode01:30: Kurts Hintergrund und Arbeit mit Spitzensportlern wie J.Klinsmann02:30: Das Konzept von Krankheit als Ungleichgewicht03:30: Einfluss von Lebensstil und Umwelt auf Gene04:35: Rolle von Phytopharmaka bei der Genreparatur05:30: Brücke zwischen traditioneller Weisheit und moderner Wissenschaft6:00: Zuckercode und die zelluläre Kommunikation7:00: Das Potenzial für unbegrenzte DNA-Reparatur8:00: Langlebigkeit und der Alterungsprozess9:00: Telomere, Yamanaka-Gene und zelluläre Verjüngung10:00: Lebensstil als mächtiger Einfluss auf die GesundheitErfahre in diesem Gespräch mit Kurt Mosetter mehr über die Geheimnisse des Zuckercodes und wie dieser unsere Gesundheit steuert. Durch seine Zusammenarbeit mit Spitzensportler:innen und seine Beteiligung an der Werner Mosetter Stiftung verfügt er über umfangreiche Erfahrungen und erklärt, warum Krankheiten sich immer auf Ungleichgewichte zurückführen lassen und in Verbindung mit der Darmgesundheit stehen. Kurt hebt Substanzen wie Myrobalan, Kurkumin und Weihrauchharz als mächtige Werkzeuge zur DNA-Reparatur hervor. Erfahre, wie diese natürlichen Mittel dazu beitragen können, deine Gene zu beeinflussen und dich von Krankheiten zu befreien. Du willst mehr erfahren? Schreibe eine E-Mail an: christian@christian-wenzel.comMehr mr.broccoli: Podcast auf Spotify Apple Podcast Mehr Podcast Skool Community Abonniere meinen YouTube Kanal*Affiliate LinkAchtung betreffend Nahrung, Geräten und Supplements:Vorliegend habe ich meine eigene Erfahrung und die von Interviewpartnern genannt. Das sind die Effekte, die ich bei mir gespürt habe. Diese können bei jedem unterschiedlich ausfallen.Natürlich kann kein Lebensmittel, keine Nahrungsergänzung oder Superfoods sowie Inspirationen aus diesem Podcast alleine für sich eine Heilwirkung erzielen oder versprechen.Die beschriebenen Erfahrungen sind keine wissenschaftlichen Erkenntnisse und keine Tatsachenbehauptungen. Sämtliche Inhalte dieser Podcast Episoden sind keine Heilaussagen und ausschließlich informativ, sie dienen keinesfalls als Ersatz für eine ärztliche Behandlung.Die Aussagen der Interview Gäst:innen stehen für sich. Diese spiegeln nicht zwingend die Meinung des Herausgebers.
Are you aging faster than you should be? Our toxic environment and chronic stress are adding to this longevity issue, but there may be a solution to reducing inflammation and slowing down aging. In this episode of The Longevity podcast, I am joined by Dr. Bill Lawrence to discuss bioregulator peptides and their role in slowing down the aging process and enhancing health. We discuss the primary driver of aging, how peptides can repair and rejuvenate this system, and the potential of peptide bioregulators in delaying the aging process. We also dive into the significant investments being made in regenerative medicine, the use of peptide bioregulators in treating specific conditions, such as retinal issues, and the positive impact of stress management on longevity. Dr. Bill Lawrence is an American biogerontologist with a Jurisprudence Degree (UCLA-Law), an MS in Psychology, and a Ph.D. in Nutritional Science. For three decades, his focus has been human longevity research and interventions for optimal life and healthspan. Thank you to our sponsors for making this episode possible: Berkeley Life: Consumers may register and place an order using my code NIDDBL for 10% off at berkeleylife.com Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Join Nat's Membership Community: https://www.natniddam.com/bsp-community Sign up for Nats Newsletter: https://landing.mailerlite.com/webforms/landing/i7d5m0 Instagram: https://www.instagram.com/nathalieniddam/ Website: www.NatNiddam.com Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance What We Discuss: 08:55 Understanding Bioregulator Peptides 20:25 The DNA Repair Mechanism and Aging 34:24 Repairing the DNA Repair Mechanism with Peptides 37:57 The Power of Peptide Bioregulators in Enhancing Health and Longevity 40:03 Holistic Health and Peptide Bioregulators 45:14 Treating Specific Conditions with Peptide Bioregulators 53:46 The Impact of Peptide Bioregulators on Telomere Length 59:41 Stress and its Effect on Telomeres 01:09:03 The Role of Relationships in Longevity
We know that how we live affects how we age, and in this episode, rather than focusing on longevity per se, I look at the biology of ageing and how we can adopt simple daily habits to positively affect the factors that age us. I also talk about my Health Loop and your 'typical day' to help lay out your unique needs for a lifestyle prescription.Links:The fear of ageing: https://www.forbes.com/health/medicare/fear-of-aging-survey/Causes of death by country: https://ourworldindata.org/data-insights/whats-the-leading-cause-of-death-in-each-countryTelomere length: https://learn.genetics.utah.edu/content/basics/telomeres/Telomere length and habits: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316700/Epigenetics basics: https://www.psychologytoday.com/gb/basics/epigeneticsDNA methylation: https://www.whatisepigenetics.com/dna-methylation/Proteostasis - how our bodies handle and house protein: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539002/Mitochondirlal dysfunction: https://www.nature.com/articles/s41392-024-01839-8Stem cells: https://www.mayoclinic.org/tests-procedures/bone-marrow-transplant/in-depth/stem-cells/art-20048117#Dr Michael Mosley's Just One Thing: https://www.bbc.co.uk/programmes/p09by3yy/episodes/downloadsStanding desks: https://www.bbc.co.uk/news/uk-45819203Healthy anger: https://www.psychologytoday.com/gb/blog/overcoming-destructive-anger/201608/what-constitutes-healthy-angerTHE HEALTH FIX: https://www.amazon.co.uk/Health-Fix-Dr-Ayan-Panja/dp/1914239326/ref=tmm_pap_swatch_0?_encoding=UTF8&qid=&sr=Protein and ageing: https://www.healthline.com/health-news/high-protein-fewer-calories-safest-way-for-older-people-to-lose-weight Hosted on Acast. See acast.com/privacy for more information.
TIME STAMPS: 00:54 PETER, from Bulgaria - IG @ gods.ofwar1 - THE ARM WRESTLING BODYBUILDER from BULGARIA!!! 07:22 BLEEDING GUMS - why you might experience this when you go keto at first and what to do if this happens! 11:39 Davina - Ireland - my new client is new to carnivore as of a couple weeks to help with ANXIETY, STOMACH PAIN & POOR SLEEP
In this enlightening episode, CJ delves into the fascinating world of telomeres, the protective caps at the ends of chromosomes that play a crucial role in aging and overall health. Discover practical lifestyle changes and habits that can help maintain and even lengthen your telomeres, promoting a longer, healthier life.Key Topics Discussed:Introduction to Telomeres:Telomeres are compared to plastic tips on shoelaces, protecting chromosome ends from damage.Importance in aging and disease prevention.Impact of Telomere Length:Shortened telomeres linked to aging and higher risks of diseases like heart disease, diabetes, and cancer.Ways to Support Telomere Health:Regular Exercise: At least 150 minutes of moderate or 75 minutes of high-intensity exercise weekly.Healthy Diet: Focus on antioxidants, anti-inflammatory foods, omega-3 fatty acids, and avoid processed foods.Stress Reduction: Engage in mindfulness, meditation, yoga, and activities that bring joy.Quality Sleep: Aim for 7-9 hours per night with a relaxing bedtime routine.Supplements: Consider TA-65 from astragalus, but consult a healthcare provider first.Additional Tips:Mind-Body Practices: Tai chi, qigong, and other exercises to reduce stress.Caloric Restriction: Mindful eating without malnutrition.Plant-Based Diet: Rich in fruits, vegetables, legumes, and whole grains.Green Tea: High in antioxidants like EGCg.Vitamin D: Ensuring adequate levels through sun exposure, diet, or supplements.Social Connections: Maintaining strong relationships for better health and longevity.Key Takeaways:Exercise Regularly: Aim for a mix of moderate and high-intensity activities.Eat a Nutritious Diet: Emphasize antioxidants, omega-3s, and avoid processed foods.Manage Stress: Practice mindfulness, meditation, and engage in joyful activities.Prioritize Sleep: Ensure 7-9 hours of quality sleep per night.Consider Supplements: Explore options like TA-65 with professional guidance.Actionable Steps:Start Exercising: Incorporate walking, running, or strength training into your weekly routine.Revamp Your Diet: Add more fruits, vegetables, whole grains, and omega-3-rich foods.Practice Mindfulness: Set aside time for meditation or yoga daily.Improve Sleep Hygiene: Create a calming bedtime routine and optimize your sleep environment.Build Connections: Strengthen your social ties and engage in meaningful relationships. Supporting your telomeres involves a comprehensive approach to health, combining physical activity, nutrition, stress management, sleep, and social interactions. Implement these practices to not only protect your telomeres but also invest in a longer, healthier life.
Send us a Text Message.The podcast discusses several health topics including migraines, the vagus nerve, and salt consumption. The panel talk about the link between migraines and a variety of factors such as lack of sleep, stress, and certain foods. They also discuss the importance of omega-3 fatty acids and how vegetable oils can affect the body's ability to produce vitamin D, leading to sunburns. The podcast concludes with a discussion on the benefits of Celtic Sea salt over Pink Himalayan salt. Ben and Richard talk about the upcoming Carnivore Conference and how they got into the carnivore lifestyle. They discuss migraines and how a ketogenic, carnivore diet may help reduce them. Richard shares his personal experience with migraines and their potential causes. They also mention some other contributing factors such as grains, calcium and magnesium imbalances, and the benefits of beta hydroxybutyrate in reducing neuroinflammation. Eating plant-based food and taking sun supplements are not enough to keep adequate vitamin D levels. UVB rays interact with our skin and cholesterol to produce vitamin D, which acts as a sunscreen and hormone in our body. Eating meat has been shown to have a positive impact on telomeres, the protective caps at the ends of our DNA strands. Come join us at the Carnivore Conference to learn more about health and nutrition!Thank you so much for listening to my podcast. I hope you enjoyed it. Your support means the absolute world to me. And if you're enjoying the show, I've got a small favor to ask you. I'd be incredibly grateful if you would consider becoming a supporter and make a small monthly donation. Your contribution will really help to improve the show. It's a small monthly contribution. You can cancel at any time, and the link is in the show notes. Support the Show.All my links in 1 easy list, including booking and personal training workout plans at LINKTREE You can now download the carnivore experience appApple direct link for apple devices Google play store direct link to app for Android Coach Stephen's Instagram Book me for coaching My growing UK carnivore YouTube channel I have set up a community that is all about eating low-carb and specifically carnivore. CLICK HERE Support my podcast from just £3 per monthBECOME A SUPPORTER Success stories Optimal Health 5 Star reviews All my facebook and other reviews are here Thanks to www.audionautix.com for any music included. Ple...
In this episode, Dan and Matt are back with another of their favorite segment, "Hidden Djems." They talk about 5 bands that are insanely underrated and worth your attention: Telomere, Ethos, Frogg, Distorted Harmony, & Cold Night For Alligators. Make sure to check out each of the bands on your streaming platform of choice! ============= #prog #metal #rock #djent #progressivemetal #progressivemusic #progressiverock #mathrock #telomere #ethos #frogg #distortedharmony #coldnightforalligators #progressivedjentlemen --- Support this podcast: https://podcasters.spotify.com/pod/show/progressivedjentlemen/support
This episode is brought to you thanks to NordVPN. To get the special Space Nuts and 30 day money back guarantee deals visit www.nordvpn.com/spacenutsWeird Mars Rock, Anti-Ageing in Space, and Asteroid CollisionsJoin Andrew Dunkley and Professor Fred Watson in this fascinating episode of Space Nuts, where they delve into the latest discoveries and phenomena in space science and astronomy.Episode Highlights:- Weird Mars Rock: The Perseverance rover has discovered a peculiar rock on Mars that stands out like a sore thumb. Identified as an anorthosite, this unusual rock could offer insights into Mars' crust and its geological history.- Anti-Ageing Effects of Space Travel: A civilian space mission has revealed surprising health benefits of space travel, including the lengthening of telomeres, which are associated with anti-ageing. Fred and Andrew discuss the implications and potential future studies.- James Webb Space Telescope: The James Webb Space Telescope has observed an asteroid collision in the Beta Pictoris system. This discovery provides a glimpse into the chaotic early stages of solar system formation.Don't forget to send us your questions via our website...spacenuts.io.Support Space Nuts and join us on this interstellar journey by visiting our website support page. Your contributions help us continue our mission to explore the wonders of the universe.Clear skies and boundless exploration await on Space Nuts, where we make the cosmos your backyard.Check out our sponsor: www.nordvpn.com/spacenutsBecome a supporter of this podcast: https://www.spreaker.com/podcast/space-nuts--2631155/supportVisit our websites: www.spacenuts.iowww.bitesz.com
Human-chimpanzee similarity is a hotly-debated topic in the evolution-creation wars. Are we 98, 95, 90, or 85% similar? One way to get at the question is to ask what is the longest stretch of DNA that is shared between the two species. This is a very difficult question to answer! But, unperturbed, Dr Rob set out to answer it. Will our fearless hero be able to pull it off? Spoiler alert: not quite, but the path of discovery is still very interesting. LastZ github.com/lastz/lastz LastZ chaining github.com/hillerlab/make_lastz_chains Mummer4 mummer4.github.io/ Blast blast.ncbi.nlm.nih.gov/Blast.cgi Telomere-to-Telomere Consortium primate projects github.com/marbl/Primates Python python.org/ Standard Bases: A: Adenine C: Cytosine G: Guanine T: Thymine (in DNA) U: Uracil (in RNA) Ambiguous Bases (IUPAC Codes): These codes are used when there is ambiguity in the nucleotide present at a particular position: R: A or G (puRine) Y: C or T (pYrimidine) S: G or C W: A or T (Weak) K: G or T (Keto) M: A or C (aMino) B: C, G, or T (not A) (B comes after A) D: A, G, or T (not C) (D comes after C) H: A, C, or T (not G) (H comes after G) V: A, C, or G (not T) (V comes after U; U is replaced with T in DNA) N: Any base (A, C, G, T) (N for any nucleotide) Silver Comet Trail silvercometga.com/
Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/
Do you want to live to 100? Dietary patterns, community, environment, and stress management play pivotal roles in longevity. From Sardinia's matriarchal villages to Okinawa's garden-rich diets, this episode takes us on a tour of insights. It's not just about living longer, it's about thriving.In today's episode, Jonathan is joined by Dan Buettner and Prof. Tim Spector to discuss the secrets of a longer, healthier life. Together, they journey through the world's blue zones, rare global hotspots where celebrating your 100th birthday is common. The guests also address the threats to these longevity havens and the decline of traditional diets.Dan Buettner is an American National Geographic fellow and New York Times bestselling author. He's also an explorer, educator, and creator of the Netflix series “Live to 100,” which discovers five unique communities where people live extraordinarily long and vibrant lives.Tim Spector is a professor of genetic epidemiology at King's College London, director of the Twins UK study, scientific co-founder of ZOE, and one of the world's leading researchers. He's also the author of Food for Life, his latest book on nutrition and health.If you want to uncover the right foods for your body, head to zoe.com/podcast, and get 10% off your personalized nutrition program.Gut health tips from ZOE Science & Nutrition: Download our FREE gut guide.Follow ZOE on Instagram.Timecodes:00:00 Introduction01:09 Quickfire questions02:33 What are Blue Zones?04:43 Why do people in Blue Zones live longer?06:48 What is a Centenarian?09:00 What are Blue Zone diets?11:49 Foods for longevity15:03 Why are these foods good for us?19:15 Why Blue Zone diets are seasonal and inexpensive 22:30 Is eating meat 5 times a month healthy for us?27:42 Why are the Blue Zones disappearing?31:25 Blue Zone tactics to reduce stress36:02 Can stress reduce life expectancy?40:36 Why unconscious physical activity is best45:07 How can we make our lives more ‘Blue Zone' like?47:23 The number one thing you can do to add years to your life is…48:53 Dan's stress reduction techniques51:39 What is Dan's daily diet?53:16 SummaryMentioned in today's episode:Telomere shortening and the transition to family caregiving in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study from PLOS OneBooks and series from Dan Buettner:The Blue Zones Challenge: A 4-Week Plan for a Longer, Better LifeThe Blue Zones Secrets for Living Longer: Lessons From the Healthiest Places on Earth
Can modern medicine reverse the aging process and extend our lifespan?Explore the evolution of anti-aging from wellness and hormone therapies to cutting-edge regenerative medicine. Learn how treatments like stem cell therapy, sleep apnea management, and hormone replacement can add years to your life.Cells accumulate damage as we age which may lead to organ degeneration. Nobody wants to have unhealthy organs. Modern techniques such as full-body MRIs for cancer detection allow us to spot health risks at their early stages. Healthcare professionals may opt for Telomere and epigenetic markers to measure and potentially reverse aging.Uncover the power of personalized healthcare in not just prolonging life but enhancing its quality. Take advantage of this fascinating journey into the future of age-reversal medicine. Drug therapies have been proven to be vital in slowing aging, too!Did you know that managing health conditions such as high blood pressure and diabetes is crucial to your longevity efforts? For a successful anti-aging regimen, Dr. Charles Mok reminds us to take one step at a time.Tune in to this new episode of Inside The Cure podcast — Age Reversal: Medicine and Treatments. ————————————————————————————————Enjoy the episode? Don't forget to leave us a five-star review!Dr. Charles Mok received his medical degree from Chicago College of Osteopathic Medicine, Chicago, Illinois in 1989. He completed his medical residency at Mount Clemens General Hospital, Mt. Clemens, Michigan. He has worked with laser manufacturing companies to improve their technologies; he has performed clinical research studies and has taught physicians from numerous other states. His professionalism and personal attention to detail have contributed to the success of one of the first medical spas in Michigan.LinkedIn: https://www.linkedin.com/in/charles-mok-4a0432114/Instagram: https://www.instagram.com/alluremedicals/Website: https://www.alluremedical.com/YouTube: https://www.youtube.com/@AllureMedicalAmazon Store: https://www.amazon.com/stores/Dr.-Charles-Mok/author/B0791M9FZQ?ref=ap_rdr&store_ref=ap_rdr&isDramIntegrated=true&shoppingPortalEnabled=true
In this weeks episode we catch up with Dr Bill Andrews who happens not only to be a top age level ultra marathon athlete who has competed in literally hundreds of ultramarathons in his life time including some of the absolute toughest like the Badwater Ultramarathon and La Ultra - The High, two that I know well, but he is also a world leading longevity scientist who focuses his research mostly on telomeres and extending life span and health span. Telomeres are found at the tips of our chromosomes and have been shown, in thousands of scientific peer-reviewed studies, to be the clock of aging in humans. When telomeres get shorter, we get older, and our health declines. Dr Bill says that while telomeres may not be the single cure for ageing, we can't cure ageing without fixing the telomere shortening problem. Telomere attrition (shortening) is one of the known hallmarks of aging and Dr Bill shares in this insightful interview how we can: slow or even reverse ageing through the lengthening of our telomeres: how he discovered the worlds most powerful telomerase inducing substances. what we can expect in the near future and how we can harness this knowledge today what we can do from a lifestyle perspective to slow the shortening of our telomeres why lengthening telomere protects you from cancer rather than causing cancer as has been rumored in the past. what the longevity and anti-aging field doing today and how he believes that the many breakthroughs are already here or coming very soon. he elaborates on his life long mission to cure ageing and what he does personally to at age 72 to prevent the normal declines (hint - he still running 100 milers and going for an age group record in the next year or two. If you want to delay disease, decline and decrepitude then this is the podcast for you! As a scientist, athlete, and executive, Bill continually pushes the envelope and challenges convention. He has been featured in Popular Science, The Today Show, and numerous documentaries on the topic of life extension including, most recently, the movie The Immortalists in which he co-stars with Dr. Aubrey de Grey. See www.theimmortalists.com/watch. Bill is known for being a scientist first, focusing on scientific research, allowing others, instead, to market the products that his company discovers. Bill has been a medical researcher in biotech since 1981, focusing on cancer, heart disease, and inflammation research, while at Geron Corporation, Bill led the research to discover both the RNA and protein components of the human enzyme called telomerase. This enzyme is responsible for preventing telomeres from shortening in human reproductive cells, and this is why our children are born younger than we are even though they come from our old cells. Inducing this enzyme to lengthen telomeres in all our cells, not just our reproductive cells, to reverse aging and declining health due to aging, is the principal goal of Sierra Sciences and Sierra Holdings. You can see what Dr. Bill is up to at www.sierrasci.com Dr. Bill is the author of "Curing Aging" and "Telomere Lengthening" BIO Dr. Bill Andrews is the Founder and CEO of Sierra Sciences and Sierra Holdings, a companies are focused on finding ways to extend human lifespan and health span through telomere maintenance. Telomeres are found at the tips of our chromosomes and have been shown, in thousands of scientific peer-reviewed studies, to be the clock of aging in humans. When telomeres get shorter, we get older, and our health declines. As a scientist, athlete, and executive, Bill continually pushes the envelope and challenges convention. He has been featured in Popular Science, The Today Show, and numerous documentaries on the topic of life extension including, most recently, the movie The Immortalists in which he co-stars with Dr. Aubrey de Grey. See www.theimmortalists.com/watch. Bill is known for being a scientist first, focusing on scientific research, allowing others, instead, to market the products that his company discovers. Bill has been a medical researcher in biotech since 1981, focusing on cancer, heart disease, and inflammation research, though his passion has always been aging. In the early-to-mid 1990s, while at Geron Corporation, Bill led the research to discover both the RNA and protein components of the human enzyme called telomerase. This enzyme is responsible for preventing telomeres from shortening in human reproductive cells, and this is why our children are born younger than we are even though they come from our old cells. Inducing this enzyme to lengthen telomeres in all our cells, not just our reproductive cells, to reverse aging and declining health due to aging, is the principal goal of Sierra Sciences and Sierra Holdings. website: https://sierrasci.com/ The Immortalists Movie: https://theimmortalists.com/watch/ Best Choice Medicine petition, that you can sign today: https://www.bestchoicemedicine.com/ Personalised Health Optimisation Consulting with Lisa Tamati Lisa offers solution focused coaching sessions to help you find the right answers to your challenges. Topics Lisa can help with: Lisa is a Genetics Practitioner, Health Optimisation Coach, High Performance and Mindset Coach. She is a qualified Ph360 Epigenetics coach and a clinician with The DNA Company and has done years of research into brain rehabilitation, neurodegenerative diseases and biohacking. She has extensive knowledge on such therapies as hyperbaric oxygen, intravenous vitamin C, sports performance, functional genomics, Thyroid, Hormones, Cancer and much more. She can assist with all functional medicine testing. Testing Options Comprehensive Thyroid testing DUTCH Hormone testing Adrenal Testing Organic Acid Testing Microbiome Testing Cell Blueprint Testing Epigenetics Testing DNA testing Basic Blood Test analysis Heavy Metals Nutristat Omega 3 to 6 status and more Lisa and her functional medicine colleagues in the practice can help you navigate the confusing world of health and medicine . She can also advise on the latest research and where to get help if mainstream medicine hasn't got the answers you are searching for whatever the challenge you are facing from cancer to gut issues, from depression and anxiety, weight loss issues, from head injuries to burn out to hormone optimisation to the latest in longevity science. Book your consultation with Lisa Join our Patron program and support the show Pushing the Limits' has been free to air for over 8 years. Providing leading edge information to anyone who needs it. But we need help on our mission. Please join our patron community and get exclusive member benefits (more to roll out later this year) and support this educational platform for the price of a coffee or two You can join by going to Lisa's Patron Community Or if you just want to support Lisa with a "coffee" go to https://www.buymeacoffee.com/LisaT to donate $3 Lisa's Anti-Aging and Longevity Supplements Lisa has spent years curating a very specialized range of exclusive longevity, health optimizing supplements from leading scientists, researchers and companies all around the world. This is an unprecedented collection. The stuff Lisa wanted for her family but couldn't get in NZ that's what it's in her range. Lisa is constantly researching and interviewing the top scientists and researchers in the world to get you the best cutting edge supplements to optimize your life. Subscribe to our popular Youtube channel with over 600 videos, millions of views, a number of full length documentaries, and much more. You don't want to miss out on all the great content on our Lisa's youtube channel. Youtube Order Lisa's Books Lisa has published 5 books: Running Hot, Running to Extremes, Relentless, What your oncologist isn't telling you and her latest "Thriving on the Edge" Check them all out at https://shop.lisatamati.com/collections/books Perfect Amino Supplement by Dr David Minkoff Introducing PerfectAmino PerfectAmino is an amino acid supplement that is 99% utilized by the body to make protein. PerfectAmino is 3-6x the protein of other sources with almost no calories. 100% vegan and non-GMO. The coated PerfectAmino tablets are a slightly different shape and have a natural, non-GMO, certified organic vegan coating on them so they will glide down your throat easily. Fully absorbed within 20-30 minutes! No other form of protein comes close to PerfectAminos Listen to the episode with Dr Minkoff here: Use code "tamati" at checkout to get a 10% discount on any of their devices. Red Light Therapy: Lisa is a huge fan of Red Light Therapy and runs a Hyperbaric and Red Light Therapy clinic. If you are wanting to get the best products try Flexbeam: A wearable Red Light Device https://recharge.health/product/flexbeam-aff/?ref=A9svb6YLz79r38 Or Try Vielights' advanced Photobiomodulation Devices Vielight brain photobiomodulation devices combine electrical engineering and neuroscience. To find out more about photobiomodulation, current studies underway and already completed and for the devices mentioned in this video go to www.vielight.com and use code “tamati” to get 10% off Enjoyed This Podcast? If you did, subscribe and share it with your friends! If you enjoyed tuning in, then leave us a review and share this with your family and friends. Have any questions? You can contact my team through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts. To pushing the limits, Lisa and team
Chapter 1 What's The Telomere Effect Book by Elizabeth Blackburn"The Telomere Effect: A Revolutionary Approach to Living Younger, Healthier, Longer" is a book written by Elizabeth Blackburn, a molecular biologist and Nobel laureate, and Elissa Epel, a health psychologist. Published in 2017, the book focuses on the role of telomeres, the protective caps at the end of chromosomes, in the aging process and overall health.Blackburn and Epel explain how lifestyle choices, such as diet, stress management, exercise, and social connections, can influence the length and health of telomeres. The book also explores the science behind telomeres, highlighting the correlation between telomere length and various diseases, including cancer, heart disease, and dementia."The Telomere Effect" offers practical strategies and recommendations to maintain and improve telomere health, ultimately promoting longevity and overall well-being. Through clear explanations and compelling scientific evidence, Blackburn and Epel provide insights into how individuals can make positive changes to support the health of their telomeres and, consequently, the health and lifespan of their cells and body.Chapter 2 Is The Telomere Effect Book A Good Book"The Telomere Effect: A Revolutionary Approach to Living Younger, Healthier, Longer" by Elizabeth Blackburn is generally considered a good book. Elizabeth Blackburn is a renowned scientist and Nobel Laureate, known for her groundbreaking research on telomeres. The book explores the concept of telomeres, the protective caps at the ends of chromosomes, and their connection to aging and health. It provides insights into the importance of lifestyle choices, such as managing stress, exercising, and maintaining a healthy diet, in preserving telomeres and promoting overall well-being. Many readers have found the book's scientific information and practical advice valuable for understanding longevity and living a healthier life.Chapter 3 The Telomere Effect Book by Elizabeth Blackburn SummaryThe Telomere Effect is a book written by Elizabeth Blackburn and Elissa Epel that explores the role of telomeres in aging and health. Telomeres are the protective caps at the ends of our chromosomes that shorten as we age.The book begins by explaining the science behind telomeres and their relationship to aging. It discusses how telomere length can be influenced by various factors, such as genetics, lifestyle choices, and stress. The authors also explain the enzyme telomerase, which can lengthen telomeres and potentially slow down the aging process.Blackburn and Epel then delve into the various ways in which telomere length can impact our health. They provide evidence linking shorter telomeres to a higher risk of age-related diseases, such as heart disease, cancer, and dementia. They also explore how telomere length can affect our mental health, stress levels, and overall well-being.Next, the book offers practical strategies and lifestyle changes that can help maintain or lengthen telomeres. The authors discuss the importance of exercise, nutrition, sleep, stress management, and social connections in preserving telomere length and improving overall health.The Telomere Effect also addresses the role of mindfulness and meditation in promoting telomere health. The authors explain how these practices can reduce stress, calm the mind, and positively impact telomere length.Throughout the book, Blackburn and Epel provide stories of individuals who have experienced positive changes in their health and well-being through telomere maintenance. They also provide insights from their
Grandpa Bill talks Senosense and Senolytic Drugs for Aging:What are senescent cells? How do senescent cells form? DNA damage: Telomere shortening: Oxidative stress: What are the effects of senescent cells? Secrete a variety of inflammatory molecules: Interfere with tissue repair: Contribute to cancer:. How can we target senescent cells? Senolytic drugs: Senescence-modifying drugs: What are the potential benefits of targeting senescent cells? Slowing down aging: ng or delaying age-related diseases: What is the future of senescent cell research? Senescent Cells and Their Impact on Cognitive Function Mechanisms Underlying Senescent Cell-Induced Cognitive Decline Neuroinflammation: Impaired Neurogenesis: Disruption of Synaptic Function: Evidence Supporting the Role of Senescent Cells in Cognitive Decline Animal Studies: Human Studies: Potential Therapies Targeting Senescent Cells for Cognitive Enhancement Senolytic Drugs: Senescence-Modifying Drugs: #SenescentCells, #Aging, #Cognition, #CognitiveDecline, #Alzheimer's, #Dementia, #Neurodegeneration, #SenolyticDrugs, #SenescenceModifyingDrugs, Relevant Citations and Websites Episode 1: Unraveling the Mystery of Senescent Cells: Unveiling the Aging Symptoms What are Senescent Cells? Aging Symptoms Linked to Senescent Cell Accumulation Skin Aging: Tissue Repair Impairment: . Immune System Decline: Cancer Risk: Episode 2: Combating Aging with Senescent Cell Therapies Introduction Senolytic Drugs: A Promising Approach Senescence-Modifying Drugs: An Alternative Approach Promising Research Regarding Senolytic Drugs Preclinical Evidence Clinical Trials Future Directions See the latest updates to my granddaughter- Adah's Academic Excellence Mandarin to english the following Words " Adah,I love you so much, and I am so very proud of your latest first half year of your Junior Year In High School. What a amazing accomplishment. Four A+ and 2 A's, 9th in your class. Great Job sweetie your on your way to continuing your aspirations" Please show the actual words, so I can practice my tonal inflections best hashtags and suggested titlesvolume_up Here is the translation from Mandarin to English of the following words: 阿達，我非常愛你，並且我非常為你高中三年級上半學期取得的最新成績感到驕傲。真是太棒了。四個A+和四個A，全班第九名。好工作，甜心，你正在努力實現自己的抱負。 Here is the breakdown of the translation: 阿達 (Adah) - This is the name of the person being addressed. 我非常愛你 (I love you very much) - This is a way of expressing love for someone. 並且我非常為你高中三年級上半學期取得的最新成績感到驕傲 (and I am very proud of your latest grades in the first half of your junior year of high school) - This is a way of expressing pride in someone's accomplishments. 真是太棒了 (What a great accomplishment) - This is an exclamation of praise or admiration. 四個A+和四個A，全班第九名 (Four A+s and four As, ninth in the class) - This is a statement of academic achievement. 好工作，甜心 (Good job, sweetie) - This is a way of expressing congratulations or encouragement. 你正在努力實現自己的抱負 (You are on your way to achieving your aspirations) - This is a statement of support and encouragement. #ProudParent #AcademicAchievement #JuniorYearSuccess #AdahsJourney Title: Adah's Academic Excellence: A Journey of Dedication and Success 阿达，我非常爱你，并且我非常为你高中三年级上半学期取得的最新成绩感到骄傲。真是太棒了。四个A+和四个A，全班第九名。好工作，甜心，你正在努力实现自己的抱负。 阿达 /ā dá/，我非常爱你 /wǒ fēicháng ài nǐ/，并且我非常为你高中三年级上半学期取得的最新成绩感到骄傲 /bǐngqiě wǒ fēicháng wéi nǐ gāozhōng sānniánjí shàngbànxuéqí qǔdé de zuìxīn chéngjī gǎodào jiāo'ào/。真是太棒了 /zhēn shì tài bàng le/。四个A+和四个A，全班第九名 /sì ge A+ hé sì ge A, quánbān dìjiǔ míng/。好工作，甜心 /hǎo gōngzuò, tiánxīn/，你正在努力实现自己的抱负 /nǐ zhèngzài nǔlì shíxiàn zìjǐ de bàofù/。 --- Send in a voice message: https://podcasters.spotify.com/pod/show/bhsales/message
Some life-form symbiosis from the arteriole pod manufactured by means consubstantiality. Vreemd the push knock…favoring the why not of Sprachenfolge cogency. The truncated tripartite triplet took the tristar translator to the terminus timid traductor telepath…trembling turns took them to tiramisu, the thymidine track to Telomere. DAY 31 MZTHRONE S2: Zech 6:13 Yes, it is He Who shall build the temple of the Lord, and He shall bear the honor and glory and shall sit and rule upon His throne. And He shall be a Priest upon His throne, and the counsel of peace (see day 33) shall be between the two [offices—Priest and King]. Daniel 5:20 But when his heart was lifted up and his spirit was hardened so that he dealt proudly, he was brought down from his kingly throne, and his glory was taken from him. Daniel 7:9 “While I was watching, thrones were set up, and the Ancient of Days took his seat. His attire was white like snow; the hair of his head was like lamb's wool. His throne was ablaze with fire and its wheels were all aflame. Psalms 89:36-37 His dynasty will last forever. His throne will endure before me, like the sun; it will remain stable, like the moon. His throne will endure like the skies.” Till the thrones were cast down - The Chaldee word (כרסון kâresâvân ) means, properly, thrones - seats on which monarchs sit. So far as the word is concerned, it would apply either to a throne occupied by an earthly monarch, or to the throne of God. The use of the plural here would seem to imply, at least, that the reference is not to the throne of God, but to some other throne. Maurer and Lengerke suppose that the allusion is to the thrones on which the celestial beings sat in the solemn judgment that was to be pronounced - the throne of God, and the thrones or seats of the attending inhabitants of heaven, coming with him to the solemn judgment. Lengerke refers for illustration to 1 Kings 22:19; Isaiah 6:1; Job 1:6, and Revelation 5:11-12. But the word itself might be properly applied to the thrones of earthly monarchs as well as to the throne of God. The phrase “were cast down” (רמיו remı̂yv ), in our translation, would seem to suppose that there was some throwing down, or overturning of thrones, at this period, and that the solemn judgment would follow this, or be consequent on this. S3: The film thus concludes ambiguously on a photographic image similar to one of Kathy's, inviting us to engage in the same hermeneutic processes as Condor, and ultimately "to integrate" and "reassure" ourselves with our fellow interpreters through shared meanings. A3: kâresâvân...possibly and we see the casting down and setting up of thrones. I see in this the double connotation of the number 613...the number of laws, Zechariah 6:13 and the how 613 is in involved in the gematria of the moon. and how it affects tides. Cara Savan or meaning Beloved Moon. Space Age Judaism : Mitzvot on the Moon DAY 32 MZCROWN S2: Revelation 4:9-11 (For 9-11 Jesus' Birthday) PH12 Extending the Galactic Crown - Starcaster And whenever the living creatures give glory, honor, and thanks to the one who sits on the throne, who lives forever and ever, the twenty-four elders throw themselves to the ground before the one who sits on the throne and worship the one who lives forever and ever, and they cast their crowns before his throne, saying: “You are worthy, our Lord and God, to receive glory and honor and power, since you created all things, and because of your will they existed and were created!” S3: Exposure to technocratic systems will professionalize you despite yourself, and Condor's interpellation is nearly complete. A3: Exposure to technocracy or the Theocrat will have its lasting effects. In the case of exposure to the One who lays His life down brings honor but where man seek their own honor death ultimately ensues. Going Boldly Where The Last Man has Gone Before! Decrease time over target: PayPal or Venmo @clastronaut Cash App $clastronaut
Dose of Leadership with Richard Rierson | Authentic & Courageous Leadership Development
Robert Fried is the Chief Executive Officer (CEO) of ChromaDex. Mr. Fried is an Academy Award and Emmy Award winning motion picture producer. He has held senior roles at entertainment companies Savoy Pictures (CEO), Columbia Pictures (Executive Vice President) and Fried Films (founder, CEO). He has also founded and served as CEO of internet companies Feeln (now Hallmark Movies Now), WHN (a leading e-commerce service provider), and Healthspan Research (now part of ChromaDex). Mr. Fried holds a B.S. from Cornell University and a M.B.A. from the Columbia University Graduate School of Business. In this episode of the BriteVibe podcast, Rob shares his background, which includes working with Hallmark and being involved in the production of movies like Rudy. The conversation dives into topics such as living optimally, brain health, slowing down aging and optimizing biological functions. Tune in to learn more about Rob's transition and his insights on health and wellness. Learn more from Rob Fried and TRU NIAGEN, please visit https://www.truniagen.com/. Use coupon code TAKE20 for $20 off orders $100 or more. [00:01:48] Movie producing and Hallmark. [00:08:28] Telomere technology and anti-aging. [00:14:17] Elevating NAD for anti-aging. [00:22:03] People's life-changing experiences. [00:27:52] Hair and nail growth. [00:32:38] NAD and health span.
The anti-inflammatory and antioxidant properties of plant-based diets may explain why they can effectively reverse cellular aging by elongating telomeres.
Orcas Are Attacking Boats Near Spain. Scientists Don't Know Why This Thursday, the Supreme Court restricted the scope of the Clean Water Act pertaining to wetlands, in a 5-4 vote. This could affect the Environmental Protection Agency's power to protect certain kinds of wetlands, which help reduce the impacts of flooding by absorbing water, and also act as natural filters that make drinking water cleaner. Justice Brett Kavanaugh joined the court's three liberal members in the dissent, writing that the decision will have, “significant repercussions for water quality and flood control throughout the United States.” Plus, earlier this month, three orcas attacked a boat, leading to its sinking. This is the third time an incident like this has happened in the past three years, accompanied by a large rise of orcas attacking boats near the Strait of Gibraltar. Scientists are unsure of the cause. One theory is that these attacks could be a fad, led by juvenile orcas in the area, a documented behavior in this subpopulation of the dolphin family. They could also be a response to a potential bad encounter between boats and orcas in the area. Science Friday's Charles Bergquist talks with Sophie Bushwick, technology editor for Scientific American, about these and other stories from this week in science news, including a preview of a hot El Niño summer, an amateur astronomer who discovered a new supernova, and alleviating waste problems by using recycled diapers in concrete. A Famous Sled Dog's Genome Holds Evolutionary Surprises Do you remember the story of Balto? In 1925, the town of Nome, Alaska, was facing a diphtheria outbreak. Balto was a sled dog and a very good boy who helped deliver life-saving medicine to the people in the town. Balto's twisty tale has been told many times, including in a 1990s animated movie in which Kevin Bacon voiced the iconic dog. But last month, scientists uncovered a new side of Balto. They sequenced his genes and discovered the sled dog wasn't exactly who they expected. The study published in the journal Science, was part of a project called Zoonomia, which aims to better understand the evolution of mammals, including our own genome, by looking at the genes of other animals—from narwhals to aardvarks. Guest host Flora Lichtman talks with Dr. Elinor Karlsson, associate professor in Bioinformatics and Integrative Biology at the UMass Chan Medical School and director of Vertebrate Genomics at the Broad Institute of MIT and Harvard; Dr. Katie Moon, post-doctoral researcher who led Balto's study; and Dr. Beth Shapiro, professor of ecology and evolutionary biology at UC Santa Cruz, who coauthored the new study on Balto and another paper which identified animals that are most likely to face extinction. The Long And Short Of Telomere Activity Telomeres are repeating short sequences of genetic code (in humans, TTAGGG) located on the ends of chromosomes. They act as a buffer during the cell replication process. Loops at the end of the telomere prevent chromosomes from getting inadvertently stuck together by DNA repair enzymes. Over the lifetime of the cell, the telomeres become shorter and shorter with each cell division. When they become too short, the cell dies. Telomere sequences weren't thought to do much else—sort of like the plastic tip at the end of a shoelace. Writing in the Proceedings of the National Academy of Sciences, researchers now argue that telomeres may actually encode for two short proteins. Normally, those proteins aren't released into the cell. However, if the telomere is damaged—or as it gets shorter during repeated cell replication cycles—those signaling proteins may be able to leak out into the cell and affect other processes, perhaps altering nucleic acid metabolism and protein synthesis, or triggering cellular inflammation. Jack Griffith, one of the authors of the report and the Kenan Distinguished Professor of microbiology and immunology at the UNC School of Medicine, joins SciFri's Charles Bergquist to talk about the idea and what other secrets may lie inside the telomere. Philadelphia's Mütter Museum Takes Down Digital Resources Robert Pendarvis gave his heart to Philadelphia's Mütter Museum. Literally. He has a rare condition called acromegaly, where his body makes too much growth hormone, which causes bones, cartilage and organs to keep growing. The condition affected his heart, so much so that a heart valve leaked. He had a heart transplant in 2020. Pendarvis thought his original heart could tell an important story, and teach others about this rare condition, which is why he was determined to put it on display at the Mütter Museum. The Mütter Museum is a Philadelphia institution, a medical museum that draws hundreds of thousands of visitors to its rooms filled with anatomical specimens, models, and old medical instruments. The place is not for the squeamish. Display cases show skulls, abnormal skeletons, and a jar containing the bodies of stillborn conjoined twins. Pendarvis thought it would be the perfect home for his heart — and more. To read the rest, visit sciencefriday.com To stay updated on all-things-science, sign up for Science Friday's newsletters. Transcripts for each segment will be available the week after the show airs on sciencefriday.com.
This episode is brought to you by Rupa Health and Athletic Greens. To understand and combat rapid aging, we need to understand what causes aging, chronic diseases, and decline. We call these things the hallmarks of aging—the underlying common pathways or mechanisms of aging. Each hallmark is influenced by the others and affected by various imbalances—too much or too little of certain inputs that can negatively impact the expression and progression of the hallmark. Understanding those interactions and weblike connections is the key to solving the puzzle of aging. In today's episode of my series I'm calling Health Bites, I dive into the 10 distinct hallmarks of aging and how to address them. What I've discovered has blown my mind and changed the way I approach my own health and the health of my patients. I've compiled it all into a new book called Young Forever, which comes out on February 21, 2023. Learn more and preorder the book at youngforeverbook.com.This episode is brought to you by Rupa Health and Athletic Greens.Rupa Health is a place where Functional Medicine practitioners can access more than 2,000 specialty lab tests from over 20 labs like DUTCH, Vibrant America, Genova, and Great Plains. You can check out a free, live demo with a Q&A or create an account at RupaHealth.com.AG1 contains 75 high-quality vitamins, minerals, whole-food sourced superfoods, probiotics, and adaptogens to support your entire body. Right now when you purchase AG1 from Athletic Greens, you will receive 10 FREE travel packs with your first purchase by visiting athleticgreens.com/hyman.Here are more details from our interview (audio version / Apple Subscriber version):Disrupted hormonal and nutrient signaling (8:08 / 4:40) DNA damage and mutations (17:38 / 14:12) Telomere shortening (19:19 / 15:52) Damaged proteins (20:32 / 17:04) Epigenetic damage (22:56 / 19:29) Senescent cells (otherwise known as zombie cells) (25:11 / 21:43) Depleted energy and mitochondrial decline (26:44 / 23:17) The link between gut health and longevity (28:33 / 25:07) Stem cell exhaustion (30:38 / 27:14) Inflammaging and dysfunction in immune functioning (32:00 / 28:32) Hosted on Acast. See acast.com/privacy for more information.
This episode is brought to you by Cozy Earth, Rupa Health, Essentia, and Athletic Greens.Stress has somehow become a perceived right of passage for adults in the US. Many people feel that if they're not stressed, they're not working hard enough. And almost all of us have had stress build throughout our lives, a combination of trauma, life experiences, and our state of mind.Today on The Doctor's Farmacy, I'm excited to talk to Dr. Elissa Epel about the wide-ranging effects of chronic stress on our health and how to mitigate it to feel better and even slow the aging process. Elissa Epel, PhD is an internationally renowned health psychologist who focuses on how to live well and thrive with existential stress, despite the challenges we face personally and globally. She is a professor at UCSF and the director of UCSF's Aging, Metabolism, and Emotion Center. She is the coauthor of the New York Times bestseller The Telomere Effect which is in 30 languages. Her new book is THE STRESS PRESCRIPTION: Seven Days to More Joy and Ease.This episode is brought to you by Cozy Earth, Rupa Health, Essentia, and Athletic Greens.Get 40% off your Cozy Earth sheets at cozyearth.com and use code MARK40.Rupa Health is a place where Functional Medicine practitioners can access more than 2,000 specialty lab tests. You can check out a free, live demo with a Q&A or create an account at RupaHealth.com.Right now you can get an extra $100 off your mattress purchase, on top of Essentia's Black Friday sale, which will also take 25% OFF your mattress purchase. Go to myessentia.com/drmarkhyman to learn more.Right now when you purchase AG1 from Athletic Greens, you will receive 10 FREE travel packs with your first purchase by visiting athleticgreens.com/hyman.Here are more details from our interview (audio version / Apple Subscriber version):Uncertainty tolerance and finding comfort in the unknown (4:56 / 2:55)How our trauma history impacts our ability to tolerate uncertainty (7:06 / 5:00) The difference between acute and chronic stress (14:07 / 12:00) How our mind states impact how we experience stress (17:21 / 15:19) The impact stress has on mitochondria (29:57 / 25:00) Incorporating hormetic or “good” stress into our lives (31:57 / 27:00) How meaning, purpose, and mindset impact our lives (37:00 / 34:20) Taking a stress inventory of your life (51:29 / 46:40) Telomere health and aging (56:47 / 52:12) Mitigating stress at the start of your day (1:03:13 / 57:25) Get a copy of The Stress Prescription: 7 Days to More Joy and Ease.Mentioned in this episodeSauna use as a lifestyle practice to extend healthspan Hosted on Acast. See acast.com/privacy for more information.
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