Podcasts about creation gene editing

We have two special announcements! Very soon we will be celebrating a decade of DNA Today! That's right, we released our first episode on September 1st, 2012. It also coincides with our 200th episode. We want to mark these milestones with you on the show. So send in your favorite episode. You can write it, or better yet, record a 30-60 second voice memo sharing your favorite episode and why you enjoy listening to the show. After all, our podcast would not be possible without you loyal listeners. That's why we want to celebrate together! Send in your voice memo or written message about your fav episode of DNA Today to info@dnapodcast.com. Deadline is August 27th.Thank you to all you listeners for nominating us in the Podcast Awards, you did it! We have officially been nominated. It's year number 6 being nominated and it might be our third time winning the Best Science and Medicine Podcast Award. BUT that's only going to happen if you check your email inbox for an email from The Podcast Awards with the subject line, “Podcast Awards Final Slate Voting”'. If you got this email you are one of the few that were selected to be a voter. It's imperative that you vote! There is a hyperlink to click to get to the voting page. You do have to quickly log back in. Once you do, select DNA Today in the “Science and Medicine category”, select your other fav podcasts and then Hit the “Save Nominations” button. It's that easy. You have until September 10th to do this, but please do it now if you got the email so you don't forget! Our guest this week is Dr. Sam Sternberg, who is a protein-RNA biochemist and CRISPR expert. He runs a research laboratory at Columbia University, where he is an assistant professor in the Department of Biochemistry and Molecular Biophysics. Sam's lab explores the biology of CRISPR-Cas systems and transposable elements, and develops these systems for genome engineering. In addition to publishing his research in leading journals and speaking internationally, Sam remains actively involved in public outreach and ongoing discussions on the ethical issues surrounding genome editing. Together with Nobel Prize winner Jennifer Doudna, he co-authored a popular science book about the discovery, development, and applications of CRISPR technology. Titled A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution, which chronicles the development of CRISPR and explores bioethical aspects of the technology. Their book was a finalist for the Los Angeles Times Book Prize, and The New York Review of Books called it “required reading for every concerned citizen.”Sam received his B.A. in Biochemistry from Columbia University in 2007 and his Ph.D. in Chemistry from the University of California, Berkeley in 2014. He earned graduate student fellowships from the National Science Foundation and the Department of Defense, and was awarded the Scaringe Award from the RNA Society and the Harold Weintraub Graduate Student Award from the Fred Hutchinson Cancer Research Center. Sam worked as a Scientist and Group Leader at Caribou Biosciences before beginning his independent position at Columbia in 2018, and he is the recipient of the NIH Director's New Innovator Award, and is a Sloan Fellow, Pew Biomedical Scholar, and Schaefer Research Scholar.On This Episode We Discuss:Safety, ethical, regulatory considerations for using CRISPR technology Off target effects Working directly with Nobel Prize Winner Dr. Jennifer DoudnaThe 3 major areas of CRISPR applicationsFertility research Animal studies Human genetics Enter our giveaway for your own copy of A Crack In Creation through our social media! For updates on the Sternberg lab, visit their website or follow Sam on Twitter and LinkedIn! You can also read one of his most recent papers on the profiling of CRISPR RNA-guided transposition products here. Stay tuned for the next new episode of DNA Today on August 26th, 2022! New episodes are released on Fridays. In the meantime, you can binge over 195 other episodes on Apple Podcasts, Spotify, streaming on the website, or any other podcast player by searching, “DNA Today”. Episodes since 2021 are also recorded with video which you can watch on our YouTube channel. DNA Today is hosted and produced by Kira Dineen. Our social media lead is Corinne Merlino. Our video lead is Amanda Andreoli. See what else we are up to on Twitter, Instagram, Facebook, YouTube and our website, DNApodcast.com. Questions/inquiries can be sent to info@DNApodcast.com. PerkinElmer Genomics is a global leader in genetic testing focusing on rare diseases, inherited disorders, newborn screening, and hereditary cancer. Testing services support the full continuum of care from preconception and prenatal to neonatal, pediatric, and adult. Testing options include sequencing for targeted genes, multiple genes, the whole exome or genome, and copy number variations. Using a simple saliva or blood sample, PerkinElmer Genomics answers complex genetic questions that can proactively inform patient care and end the diagnostic odyssey for families. Learn more at PerkinElmerGenomics.com. (SPONSORED)

We chat to Debra about the merging of media, retail and entertainment in the fashion industry, ‘squad shopping', the complexities of sustainability in the sector and Andrew tries to pitch his own fashion label!Find out more about DebraWatch: My Octopus TeacherRead: A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution, Jennifer A Doudna & Samuel H SternbergListen: Scott Galloway

采访 制作丨徐涛 校对丨秘丛丛 （以下文字只是音频节目的少许补充。「硅谷早知道」每周周五中午12点准时更新，敬请期待。） 詹妮弗·杜德纳（Jennifer Doudna)，因为发明基因编辑技术 CRISPR 而受人尊敬。 但她被人所尊敬不仅仅是因为她的贡献。在过去的数年间，她一直在思考基因编辑可能对整个人类社会带来的危害。 2015年，她组织了一次由顶尖生物学家参与的伦理讨论会，在这次会议上，他们签署了一个声明，来说明 CRISPR 技术可能带来的风险和伦理问题，并建议在彻底调查和理解这项技术所能带来的功效和安全性之前，运用于人体的实验都应该被禁止。 此后，她还写了一本书 A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution，来介绍基因编辑技术的巨大变革意义，以及可能给人类这一物种演进所带来的影响。 事实上，在她的影响力下，如何看待基因编辑技术成为了过去两三年在硅谷，甚至范围更大的知识分子群体/精英群体所思考的问题。包括轰动一时的《未来简史》也充满了基因编辑技术对人类物种影响的预想和反思。 在这个世界上，杜德纳、张峰，甚至还有更多科学家，他们是可以成为“基因编辑婴儿之父/母”，只是他们没有这么去做。 很遗憾，这期节目访谈中，我们没过多谈到这一部分，那就是：没有谁比科学家本身更能理解一个技术本身带来的威力，因此科学家在技术伦理问题上的审慎也成为了必要的美德。 在这期节目中，我们分析了用基因技术去编辑胎儿这个实验，何止是没有审慎： 为什么要枉顾 CRISPR 技术才诞生6年，且并不成熟的事实？ 为什么要不顾学界的惯例，在没有更充分的数据和准备的情况下，就直接用人类做实验？ 为什么这个实验试图解决的问题，是一个其实有其它更容易解决方案的问题？ 为什么这个实验的实验对象一定要用胎儿，一种可能会让被编辑基因流入人类基因库的载体？ 这个实验除了噱头之外，究竟还有什么技术或者科学发现上的突破？ 还有更多问题，可以让更多人反思： 贺建奎这样做的动力出自哪里 为何世界第一例人类胚胎修改，以及第一例基因编辑婴儿都出在中国 伦理审查委员会在起什么作用 本期嘉宾 张璐，硅谷风险投资机构 Fusion Fund 创始合伙人 相关信息 A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution (https://www.amazon.com/Crack-Creation-Editing-Unthinkable-Evolution-ebook/dp/B01I4FPNNQ) 一位女科学家的两个战场 (https://cn.nytimes.com/people/20150514/t14doudnac/) CRISPR pioneer Jennifer Doudna struggles with the ethical implications of what she has wrought (https://www.latimes.com/business/hiltzik/la-fi-hiltzik-doudna-20170721-story.html) 一位饱受伦理争议，又在和死亡赛跑的创业者 (https://36kr.com/audio/33126)

Christine Shearer is Senior R&D Engineer at Annie’s Homegrown in Berkeley, CA. We talk about food science, socially responsible practices, and innovation. For more information: Annie’s Homegrown website A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution by Jennifer A. Doudna and Samuel H. Sternberg Sporkful podcast BBC’s The Food Chain podcast

(Repeat) The biotech tool CRISPR lets us do more than shuffle genes.  Researchers have embedded an animated GIF into a living organism’s DNA, proving that the molecule is a great repository for information.  This has encouraged speculation that DNA could be used by aliens to send messages.  Meanwhile, nature has seized on this powerful storage system in surprising ways.  Scientists have learned that the 98% of our genome – once dismissed as “junk” – contains valuable genetic treasure. Find out what project ENCODE is learning about the “dark genome.” Plus, how viruses became the original stealth coders, inserting their DNA into ancient bacteria and eventually leading to the development of CRISPR technology.  Discover the potential of this powerful tool, from curing disease to making pig organs transplant-friendly, and the possible dark side of quick-and-easy gene editing.   Guests: Paul Davies- Director of the Beyond Center for Fundamental Concepts in Science at Arizona State University Yin Shen- Assistant professor, Department of Neurology, Institute for Human Genetics, University of California – San Francisco, member of ENCODE team  Sam Sternberg- Assistant professor, Department of Biochemistry and Molecular Biophysics, Columbia University, and co-author of “A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution”   Hank Greely- Director, Center for Law and the Biosciences; Chair of the Steering Committee of the Center for Biomedical Ethics; and Director, Stanford Program in Neuroscience and Society

(Repeat) The biotech tool CRISPR lets us do more than shuffle genes. Researchers have embedded an animated GIF into a living organism's DNA, proving that the molecule is a great repository for information. This has encouraged speculation that DNA could be used by aliens to send messages.  Meanwhile, nature has seized on this powerful storage system in surprising ways. Scientists have learned that the 98% of our genome – once dismissed as “junk” – contains valuable genetic treasure. Find out what project ENCODE is learning about the “dark genome.” Plus, how viruses became the original stealth coders, inserting their DNA into ancient bacteria and eventually leading to the development of CRISPR technology. Discover the potential of this powerful tool, from curing disease to making pig organs transplant-friendly, and the possible dark side of quick-and-easy gene editing.   Guests: Paul Davies- Director of the Beyond Center for Fundamental Concepts in Science at Arizona State University Yin Shen- Assistant professor, Department of Neurology, Institute for Human Genetics, University of California – San Francisco, member of ENCODE team  Sam Sternberg- Assistant professor, Department of Biochemistry and Molecular Biophysics, Columbia University, and co-author of “A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution”   Hank Greely- Director, Center for Law and the Biosciences; Chair of the Steering Committee of the Center for Biomedical Ethics; and Director, Stanford Program in Neuroscience and Society Learn more about your ad choices. Visit megaphone.fm/adchoices

Dave Stangis is Vice President of Corporate Responsibility and Chief Sustainability Officer for the Campbell Soup Company. Dave created and now leads Campbell's Corporate Social Responsibility (CSR) and sustainability strategies. As such he oversees the company's execution of CSR and sustainability goals,policies, programs, engagement, and reporting, from responsible sourcing and sustainable agriculture to social impact metrics in the community. Dave co-authored 21st Century Corporate Citizenship and The Executive's Guide to 21st Century Corporate Citizenship. Dave Stangis Joins Sustainable Nation to Discuss: Leading sustainability in large organizations Linking sustainability to business strategy Sustainability programs supporting an organization's purpose, vision and strategy How Campbell's is using technology to advance sustainability Advice and recommendations for sustainability leaders What is one piece of advice you would give other sustainability professionals that might help them in their careers? I'll try to keep it to one. The one that I haven't mentioned is to really reach out and don't be afraid to network and ask questions of other leaders. You may not get a positive response from everybody, but we take care of our own in sustainability. It's still a fairly small circle. Look for some advice and learning outside of your sector. Don't just think you have to join food or automotive or travel or hospitality or in a government agency. I would try to reach out to somebody that's across the wall in terms of another sector and see what they can help with.  What are you most excited about right now in the world of sustainability? I'm a fan of the life sciences as well as the technology. I grew up in Detroit, so I'm an automotive guy as well, but I think what is happening in the way we're able to deal with some of the systems out there, what is happening in terms of designing plans, people, whether it's good or bad, the ethics around some of these ethical lives, some of these technical choices and how we communicate them, help our companies understand them, and either bring consumers along or educate them enough so they can make an informed choice. I think this is really a big opportunity. That's where you're going to see kind of the old school sustainability people focused on energy and water and waste, which we always have to focus on, but some of these new sustainability people are bringing another layer of expertise to their companies or their agencies. What is one book you would recommend sustainability professionals read? I would recommend reading lots of books. I read a great book called the Inevitable by Kevin Kelly around technology coming to bear. I read A Crack in Creation: Gene Editing, a book that Jennifer Doudna wrote about gene editing and how it comes into play out with people and in plants. I'm reading a couple of books now on artificial intelligence and algorithms. I think there's a lot of stuff to just keep reading. Force yourself and pick up something that you're interested in and study a little bit. There's a lot of great books out there. Some of the books that I read early on were some of the work by John Elkington from sustainability. Some of those were ones that sent me on my path. What are some of your favorite resources or tools that really helped you in the work that you do? I set up a lot of feeds that come to my computer and email every day. I follow a lot of different key topics and people on Twitter or Linkedin. It's really the feeds that I follow in their online newsletters. I sign up for a lot of things that compile news on topics I'm interested in. So I'll get hundreds of these newsletters every day. You just need to scan them for headlines and find stories that are interesting. Where can our listeners go to learn more about you and the work they were leading at Campbell's? There's a few places I would suggest. The Campbell CSR websites just launched. Its www.campbellcsr.com. We also have a Campbell CSR Twitter account. There's a lot of good news stories and what we're doing on there. The team is also pretty active on Twitter and Linkedin as well. Just searching around for Campbell and Campbell Soup, Campbell CSR on Linkedin and Twitter. You'd be able to track down some of the teams that are working on sustainable agriculture and working on our core team and follow us there.

Sam Harris speaks with Jennifer Doudna about the gene-editing technology CRISPR/Cas9. They talk about the biology of gene editing, how specific tissues in the body can be targeted, the ethical implications of changing the human genome, the importance of curiosity-driven science, and other topics. Jennifer A. Doudna is a professor in the Chemistry and the Molecular and Cell Biology Departments at the University of California, Berkeley, investigator with the Howard Hughes Medical Institute, and researcher in the Molecular Biophysics and Integrated Bioimaging Division at the Lawrence Berkeley National Laboratory. She is internationally recognized as a leading expert on RNA-protein biochemistry, CRISPR biology, and genome engineering. She is the author (with Samuel Sternberg) of A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution.

CRISPR technology could change the world. Essentially, CRISPR is a technique that allows scientists to make precision edits to any DNA, whether bacterial or human. The potential for this technology is huge: if scientists have the accuracy to replace just a few faulty genes, it might be possible to cure genetic disorders as serious as cystic fibrosis and Huntington's disease and as common as lactose intolerance and color-blindness. Dr. Sam Sternberg, CRISPR expert and protein-RNA biochemist, joins the Curiosity Podcast to explain the science, ethics, and future of this cutting-edge technology. Samuel H. Sternberg, PhD, will be starting his own research laboratory at Columbia University in early 2018, as an assistant professor in the Department of Biochemistry and Molecular Biophysics. Along with Jennifer Doudna, he is the co-author of A Crack in Creation, a popular science book about the discovery, development, and applications of CRISPR-Cas9 gene editing technology. More from Curiosity: Get $50 off a Full Havenly Design package with promo code CURIOSITY Start your one free month of The Great Courses Plus (Special for Curiosity Podcast listeners) Scientists Trimmed the Fat by Genetically Engineering Leaner Pigs What Is CRISPR, And How Does It Work? Scientists Are Only Just Beginning To Discover What Causes Gray Hair Scientists Turn To This Film To Make People Cry Additional resources discussed: Samuel H. Sternberg, PhD official website "A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution" "Gattaca" (1997 film starring Ethan Hawke and Uma Thurman) 'Three-parent baby' claim raises hopes — and ethical concerns (Nature) Genome-editing revolution: My whirlwind year with CRISPR (Jennifer Doudna's article in Nature) Useful Mutants, Bred With Radiation (New York Times) Sorry Hipsters, That Organic Kale Is a Genetically Modified Food (Smithsonian) Gene Editing Makes Cows Without Horns (Popular Science) Ben Mezrich's Woolly Mammoth Book Being Adapted Into Movie by Fox "Woolly: The True Story of the Quest to Revive One of History's Most Iconic Extinct Creatures" How to Extract DNA from a Strawberry (YouTube) 23andMe direct-to-consumer genetic testing Neutron-Star Collision Reveals Origin of Gold, Astronomers Say (Live Science) Astronomers Strike Gravitational Gold In Colliding Neutron Stars (NPR)To learn more about this topic and many others check out Curiosity.com, download our 5-star iOS or Android app and join the conversation on Facebook and Twitter. Subscribe on iTunes, Stitcher, Google Play Music, and everywhere else podcasts are found so you don't miss an episode! See omnystudio.com/listener for privacy information.

Over the past decade, scientists have developed what was once just the subject of dystopian fiction: gene editing technology. It's known as CRISPR. Jennifer Doudna, a professor of molecular and cell biology and chemistry at the University of California Berkeley, was a key member of the research group that developed the technology. She's also the co-author of the recent book A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution. A straightforward description of CRISPR is mind-boggling in what it suggests. As Doudna writes, “the genome — an organism’s entire DNA content, including all its genes — has become almost as editable as a simple piece of text.” It is possible that when the history of this era is written, most of our obsessions — Trump, tax rates, cybersecurity, Obamacare, NFL protests — will be forgotten, and CRISPR will be where historians focus. With great power comes great responsibility — and genuine terror. Doudna had a nightmare as her lab and others started to use CRISPR to make heritable changes in genes. She dreamed that her colleague wanted her to meet someone interested in her research — and it was Adolf Hitler with a pig face, waiting to take notes on the technology she developed. She awoke from that dream in a cold sweat. And the concerns that dream represent pushed her to discuss the implications of CRISPR technology publicly. CRISPR could do enormous good or tremendous harm — or both. In this conversation, Doudna and I discuss its possibilities, its dangers, its technical obstacles, the regulatory questions it raises, and much more. Books: The Double Helix by Jim Watson Sapiens: A Brief History of Humankind by Yuval Noah Harari The Making of the Atomic Bomb by Richard Rhodes Learn more about your ad choices. Visit megaphone.fm/adchoices

This week, Amazon primes Whole Foods, Uber has a new head, Samsung loses its head, Half-Life comes to an end(?), Germany solves "the trolley problem", and much more.  What We're Playing With Andy: HBO's Room 104: Ep. 5 “The Internet” Headlines Uber makes CEO pick official, Kalanick makes first comment Uber says it'll stop tracking riders after they're dropped off Samsung Heir Is Found Guilty of Corruption in Blockbuster Trial 'Half Life' writer reveals what could've been Episode 3 Audible Book of the Week A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution by Jennifer A. Doudna, Samuel H. Sternberg F.D.A. Approves First Gene-Altering Leukemia Treatment, Costing $475,000 Sign up at AudibleTrial.com/TheDrillDown Music Break: Lost in the Supermarket by The Clash Hot Topic: Amazon + Whole Foods Amazon Cuts Whole Foods Prices as Much as 43% on First Day Amazon's Whole Foods deal will make Alexa a lot smarter Amazon Cortana Music Break: Airbag by Radiohead Final Word: The Trolley Problem Kill animals and destroy property before hurting humans, Germany tells future self-driving cars Cummins beats Tesla to EV semi truck The Drill Down Video of the Week The Trolley Problem: Consequentialism as illustrated by “I, Robot” Subscribe! The Drill Down on iTunes (Subscribe now!) Add us on Stitcher! The Drill Down on Facebook The Drill Down on Twitter Geeks Of Doom's The Drill Down is a roundtable-style audio podcast where we discuss the most important issues of the week, in tech and on the web and how they affect us all. Hosts are Geeks of Doom contributor Andrew Sorcini (Mr. BabyMan), marketing research analyst Dwayne De Freitas, and Box product manager Tosin Onafowokan.

CRISPR is the cheapest, simplest, and most effective way of manipulating DNA. It has the power to give us the cure to HIV, genetic diseases, and some cancers. It could even help address the world’s hunger crisis. But, it may result in unforeseen consequences. The technology could lead to intentionally mutating embryos to create “better” humans. Jennifer Doudna, whose research helped create CRISPR, speaks with Aspen Institute President Walter Isaacson about the latest technological developments in gene editing and the unthinkable power to control evolution. Doudna wrote the book A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution with her fellow researcher Samuel Sternberg. This week’s recommended companion episode is “Should We Design Our Babies?.” Find it here. Follow the show on Twitter @aspenideas and Facebook at facebook.com/aspenideas. Email your comments to aspenideastogo@gmail.com.