Podcasts about vehicles

Primary & Secondary ModCastDave Agata, Doug Deaton, and Matt Landfair discuss how the media has been manipulating messages regarding recent high-profile events. Links to research resources below.Episode Sponsors:High Desert CartridgePHLster educational content: https://www.youtube.com/@PHLsterOur Patreon can be found here:https://www.patreon.com/PrimaryandSecondaryPrimary & Secondary:Website: https://primaryandsecondary.com/Facebook: https://facebook.com/primaryandsecondary/Forum: https://primaryandsecondary.com/forumComplete Audio Podcasts: https://spreaker.com/show/primary-secondary-podcastRumble: https://rumble.com/user/PrimaryandSecondaryYouTube: https://www.youtube.com/@PrimarySecondaryResurrectionModel Policies and GuidesNational Consensus Policy on Use of Force (2020).https://www.theiacp.org/sites/default/files/2020-07/National_Consensus_Policy_On_Use_Of_Force%2007102020%20v3.pdfU.S. Department of Justice – Updated Use of Force Policy (2022).https://www.justice.gov/d9/pages/attachments/2022/05/23/departments_updated_use-of-force_policy.pdfPolice Executive Research Forum. (2015). Guiding Principles on Use of Force.https://www.policeforum.org/assets/30%20guiding%20principles.pdfCase LawTennessee v. Garner, 471 U.S. 1 (1985).https://supreme.justia.com/cases/federal/us/471/1/Graham v. Connor, 490 U.S. 386 (1989).https://supreme.justia.com/cases/federal/us/490/386/Plumhoff v. Rickard, 572 U.S. 765 (2014).https://supreme.justia.com/cases/federal/us/572/765/Mullenix v. Luna, 577 U.S. 7 (2015).https://supreme.justia.com/cases/federal/us/577/7/Barnes v. Felix, 605 U.S. ___ (2025).https://www.supremecourt.gov/opinions/24pdf/23-1239_onjq.pdfBooksArtwohl, A., & Christensen, L. W. (2019). Deadly Force Encounters: Cops & Citizens Defending Themselves and Others. https://a.co/d/0crWyVDlPatrick, U. W., & Hall, J. C. (2017). In Defense of Self and Others: Issues, Facts & Fallacies - The Realities of Law Enforcement's Use of Deadly Force. https://a.co/d/0e2qglzpArticlesChristina L. Patton et al., The Influence of Police Profanity on Public Perception of Excessive Force, J. Police & Crim. Psychol. (2017). https://tinyurl.com/4yu84kwhDavid M. Blake, Cognitive Bias and Use of Force Investigations, 9 Investigative Sciences Journal. (June 2017). https://tinyurl.com/4uypv2kkLexipol Media Group. (2021). Improving Officer Safety and Reducing Risk During Non-Compliant Traffic Stops. Police1.com. https://tinyurl.com/5dc4343bM. Hunter Martaindale et al., @#%$!: The Impact of Officer Profanity on Civilians' Perception of What Constitutes Reasonable Use of Force, 26 Police Quarterly 194 (2023). https://tinyurl.com/yc7bds3xMatthew J. Sharps et al., Police Profanity and Public Judgments of Guilt and Effectiveness in Officer-Involved Shootings, J. Police & Crim. Psych. (2018). https://tinyurl.com/4na7uvh5Parham, W. (2022). 10 Tips for Felony/High Risk Traffic Stops. Police Magazine. https://www.policemag.com/blogs/patrol/blog/15307802/10-tips-for-felonyhigh-risk-traffic-stopsSimon Baldwin et al., A Reasonable Officer: Examining the Relationships Among Stress, Training, and Performance in a Highly Realistic Lethal Force Scenario, 12 Frontiers Psychol. 759132 (2022). https://tinyurl.com/ykvpc925Wolf, D. (2023). 7 Ways to Maintain Safety Around a Suspect's Vehicle. Police1.com. https://tinyurl.com/3d2x3p93Become a supporter of this podcast: https://www.spreaker.com/podcast/primary-secondary-podcast--2585240/support.

Most electric vehicles spend nearly all of their lives parked, doing nothing. But under the hood of those idle cars, a massive store of energy sits untapped. The Kia EV9, for instance, holds a 100-kilowatt-hour battery—which is equivalent to about seven home backup batteries—just waiting to be utilized. Yet despite this enormous potential, Vehicle-to-Grid (V2G) technology has remained mostly limited to small-scale pilot programs for decades. But with advanced tech hitting the market, that could soon change. In this episode, Shayle sits down with Steve Letendre, senior advisor at the Vehicle-Grid Integration Council and editor of V2G News, to explore why the V2G revolution is finally moving from concept to reality. They break down the technical battle between AC and DC architectures, tackle the looming questions around battery degradation and warranties, and debate the business models that will finally convince everyday drivers to plug their cars back into the grid. Shayle and Steve discuss topics like: - The unused energy capacity hidden in parked EVs - The technical debate, cost trade-offs, and hardware differences between off-board power conversion (DC architecture) and on-board power conversion (AC architecture). - Current compatible EV options, including the Nissan Leaf, Tesla Cybertruck, Ford F-150 Lightning, and Kia EV9 - The high upfront cost of V2G systems - Consumers' fears regarding whether discharging power to the grid will ruin their EV batteries or void manufacturer warranties. - Streamlining the V2G enrollment process via VPP programs or at point-of-sale - How financing can unlock mass V2G adoption Resources Catalyst: Repurposing EV batteries for grid storage Catalyst: How China is reshaping the global auto market Catalyst: Enter the electric supercycle Latitude Media: Electric Era is turning its EV-charging tech into a data center power play Latitude Media: The future of optimized EV charging Credits: Hosted by Shayle Kann. Produced and edited by Max Savage Levenson. Original music and engineering by Sean Marquand. Stephen Lacey is our executive editor. This episode of Catalyst is brought to you by ENGIE, the smarter energy supplier. ENGIE doesn't just provide the power to run your business — they supply the energy to move it forward, with reliable, flexible solutions built for what's next. Learn more at ⁠engieresources.com⁠. Catalyst is brought to you by EnergyHub. Peak season puts every grid to the test — and the utilities that pass are the ones that built flexible capacity before they needed it. EnergyHub works with more than 170 utilities to coordinate 2.5 million devices and 3.4 gigawatts of dispatchable flexibility through a single platform designed to perform when it counts most. See what that looks like at ⁠EnergyHub.com⁠.  Catalyst is brought to you by Bloom Energy. Bloom Energy fuel cells deliver affordable, ultra-reliable onsite power for hospitals, utilities, and data centers – at speed and at scale. Learn more by visiting⁠ ⁠⁠BloomEnergy.com⁠.

Robotaxis are spreading across the country, but the rules for policing them are still evolving. WSJ's Ellie Davis explains how local law enforcement is handling traffic violations when there's no one behind the wheel. Plus, new AI-native startups are reshaping how companies hire and grow. WSJ reporter Lindsay Ellis explains what that could mean for the future of work. Imani Moise hosts. Have you seen an AI-generated post you thought was real? We want to hear from you! Record a voice memo and send it to tnb@wsj.com or leave us a voicemail at (212) 416-2236. Sign up for the WSJ's free Technology newsletter. Learn more about your ad choices. Visit megaphone.fm/adchoices

America's top-selling economics textbook defines communism as "the most benevolent form of economic system." That single sentence sums up why Texas State Board of Education members Julie Pickren and Brandon Hall asked PJTN president Laurie Cardoza-Moore to testify as they fought a terror-linked campaign to reshape how children learn about Israel, Judaism, and American history. In this webinar, Laurie sits down with Pickren, Hall, and PJTN senior academic fellow Dr. Sandra Alfonsi to unpack what the board won, what's still ahead when high school standards return to a vote in September, and why what happens in Texas doesn't stay in Texas — it shapes curriculum for 25 other states and over 30 million schoolchildren. The conversation also turns to New York's new mayor, with Dr. Alfonsi making the case that "Commie Mamdani" undersells the real ideology at work. This is a conversation about truth in the classroom, the return of the Bible to instructional materials, and the biblical responsibility to make sure the next generation is taught to stand with Israel, not against it.Follow, share, and support PJTN's mission at PJTN.org.0:00 They Renamed Communism in Textbooks0:42 Meet PJTN and Laurie Cardoza-Moore3:20 Inside the Texas TEKS Standards Hearing7:47 Julie Pickren on Defeating CAIR's Amendments11:57 Why High School Standards Got Delayed17:59 Brandon Hall on Putting the Bible Back in Schools25:12 Communism 101: Who Controls Your Child30:20 Q&A: Banning CAIR From Testifying36:11 Free Bluebonnet Curriculum for Every State40:57 How the New Standards Will Be Enforced45:48 Rising Antisemitism and "Commie Mamdani"52:12 Dr. Alfonsi: Communism as a Vehicle for Islamism55:28 Erasing Jewish History From Textbooks1:07:01 Closing Thoughts and How to Get InvolvedDon't forget to subscribe, rate, and share to help us equip more Christians to stand with Israel and fight antisemitism.✨ Stay connected with PJTN! ✨

Clarence Ford spoke to Chief Director Traffic Management, Maxine Bezuidenhout about the city’s free vehicle checks. Views and News with Clarence Ford is the mid-morning show on CapeTalk. This 3-hour long programme shares and reflects a broad array of perspectives. It is inspirational, passionate and positive. Host Clarence Ford’s gentle curiosity and dapper demeanour leave listeners feeling motivated and empowered. Known for his love of jazz and golf, Clarrie covers a range of themes including relationships, heritage and philosophy. Popular segments include Barbs’ Wire at 9:30am (Mon-Thurs) and The Naked Scientist at 9:30 on Fridays. Thank you for listening to a podcast from Views & News with Clarence Ford Listen live on Primedia+ weekdays between 09:00 and 12:00 (SA Time) to Views and News with Clarence Ford broadcast on CapeTalk https://buff.ly/NnFM3Nk For more from the show go to https://buff.ly/erjiQj2 or find all the catch-up podcasts here https://buff.ly/BdpaXRn Subscribe to the CapeTalk Daily and Weekly Newsletters https://buff.ly/sbvVZD5 Follow us on social media: CapeTalk on Facebook: https://www.facebook.com/CapeTalk CapeTalk on TikTok: https://www.tiktok.com/@capetalk CapeTalk on Instagram: https://www.instagram.com/ CapeTalk on X: https://x.com/CapeTalk CapeTalk on YouTube: https://www.youtube.com/@CapeTalk567See omnystudio.com/listener for privacy information.

In this live stream I'll be reacting to TLT RD21, discussing the biggest dilemmas of RD21, the buys, holds and sells, best trade targets, captaincy and more! (apologies for the audio in the 1st minute or so, it corrects itself)I read every comment and so please leave any comments, suggestion or feedback in the comments below! And if you enjoyed the video, hit that like button and subscribe for more content!Vehicle finance for SuperCoach listeners:https://getfin.com.au/supercoachLeague code: 564671Instagram: https://www.instagram.com/pumicestone_passage_piratesFacebook: https://www.facebook.com/profile.php?id=61581662431393Follow me on Patreon:!https://patreon.com/AmanTalksNRLSuperCoach?utm_medium=unknown&utm_source=join_link&utm_campaign=creatorshare_creator&utm_content=copyLinkNRL SuperCoach Stats:https://www.nrlsupercoachstats.com/Follow me on Twitter: !https://twitter.com/AmanTalksNRLSCFollow me on Instagram:!https://www.instagram.com/amantalksnrlsupercoach/?igsh=MWE1N2szbGJobDF1ZA%3D%3D&utm_source=qr

It's Monday, July 20. Here are today's top stories around Central Indiana. Want to go deeper on the stories you hear on WFYI News Now? Visit wfyi.org and follow us on social media to get local news every day. WFYI News Now is hosted by Barb Anguiano and produced by Zach Bundy. Subscribe wherever you get your podcasts.

San Francisco Mayor Daniel Lurie wants the state to set higher standards for Waymo's robotaxis. For more, KCBS Radio News Anchor Steve Scott spoke with KCBS Insider Phil Matier.

This week on Classic Vinyl Podcast, Justin and Tyler listen to and review Ides of March and their 1970 hit song Vehicle. Give it a listen and let us know what you think. 

Allan's story telling is next level, but we covered the following topics in depth. Great topics for any young business wanting to refine their business in these systems; Trailer design and durability Equipment selection and maintenance Pricing strategies for profitability Vehicle towing capacity and safety Business growth and client management Business strategies for landscapers Equipment choices and maintenance Time management and scheduling Industry trends and adaptations Client relationship management

This Week on the Toy Power Podcast; we dive back into our regular News Segment - with quite a bit to cover! First off, a recap from Episode 1 (of 4) from Trent's latest Lego Masters Bricktacula Event! Then, an exciting announcement from Cards & Collectables season 2 - now with an official release date! A New 4-Armed Beast is announced for the MOTU Origins line; who is hyped for this?! New Movie MOTU characters announced plus some awesome TMNT plus Ghostbusters multi-packs from Mondo. S7 Silverhawks keep on delivering more characters; & Blokees tease an Absolute Batman. McFarlane announces more Batman related characters; then Robosen showcase the most Superior Decepticon of them all! The Cross-Over nobody asked for? -Transformers X Scooby Doo offer. Sometimes you think that some modern toys can't do any better; but somehow, SH Figuarts said "Hold My Beer!" Lego showcase the first round of Pokémon Mini-Figures plus in scale Pokémon Characters too; all in a very nice looking Build. Then Ben tests the lads with the return of The Quiz! Is it too hard? How many did you know? Support the show: http://patreon.com/toypowerpodcastSee omnystudio.com/listener for privacy information.

CapeTalk’s Sara-Jayne Makwala King is joined on Weekend Breakfast by Motoring contributor to News24, Melinda Ferguson, who reviews the latest cars on the road and keeps us up to date with motor industry news. This week’s car: New Merc CLA, and she also chats about the GAC Nova Emzoom. Weekend Breakfast with Sara-Jayne Makwala King is the weekend breakfast show on CapeTalk. This 3-hour morning programme is the perfect (and perky!) way to kickstart your weekend. Author and journalist Sara-Jayne Makwala-King spends 3 hours interviewing a variety of guests about all things cultural and entertaining. The team keeps an eye on weekend news stories, but the focus remains on relaxation and restoration. Favourites include the weekly wellness check-in on Saturdays at 7:35 am and heartfelt chats during the Sunday 9 am profile interview. Listen live on Primedia+ Saturdays and Sundays between 07:00 and 10:00 am (SA Time) to Weekend Breakfast with Sara-Jayne Makwala-King broadcast on CapeTalk https://buff.ly/NnFM3Nk For more from the show, go to https://buff.ly/AgPbZi9 or find all the catch-up podcasts here https://buff.ly/j1EhEkZ Subscribe to the CapeTalk Daily and Weekly Newsletters https://buff.ly/sbvVZD5 Follow us on social media: CapeTalk on Facebook: https://www.facebook.com/CapeTalk CapeTalk on TikTok: https://www.tiktok.com/@capetalk CapeTalk on Instagram: https://www.instagram.com/ CapeTalk on X: https://x.com/CapeTalk CapeTalk on YouTube: https://www.youtube.com/@CapeTalk567 See omnystudio.com/listener for privacy information.

Thomas Savidge proposes "Universal Savings Accounts" (USA) to replace complex government-managed savings vehicles. These accounts would grant individuals full ownership of their funds for unemployment or retirement. This reform aims to reduce fraud and address the long-term fiscal instability associated with the national "debt bomb." (16)1933 PERSIA

In the Electrek Podcast, we discuss the most popular news in the world of sustainable transport and energy. In this week's episode, we discuss Tesla shareholders potentially starting to wake up, Xpeng targeting the European market, VW going cheaper with its EVs, and more.

Twelve people, comprising nine males and three females, have died in a gory accident involving three vehicles at Konongo, near the Anglican Basic School. Forty-four others sustained injuries, with 30 reported to be in critical condition

Acting Attorney General Todd Blanche clashes with Democrat senators during a contentious confirmation hearing as undecided Republican Senator John Cornyn emerges as the pivotal vote on his nomination. President Trump reverses DHS restrictions on ICE vehicle stops less than 24 hours after they were imposed following two fatal enforcement encounters - former Acting DHS Secretary Chad Wolf weighs in. A former Arizona Democrat Party official and so-called transgender activist faces felony charges after allegedly forcing his way into an ex-partner's home with a knife and black tape. The House advances President Trump's push to make daylight saving time permanent by voting to end the twice-yearly clock change.   Subscribe now to Emily's "After Party": Apple: https://podcasts.apple.com/us/podcast/after-party-with-emily-jashinsky/id1821493726 Spotify: https://open.spotify.com/show/0szVa30NjGYsyIzzBoBCtJ YouTube: https://www.youtube.com/@AfterPartyEmily?sub_confirmation=1   Supersure Insurance: Upgrade your business insurance to a year-round SuperAgency at https://Supersure.com/Megyn   ARMRA: go to https://tryarmra.com/MEGYNto get 30% off your first subscription order Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Today's Poll Question at Smerconish.com: Should ICE end all vehicle stops? Following two fatal ICE traffic-stop shootings, President Trump has ordered immigration agents to resume the controversial enforcement tactic, reigniting a fierce debate over public safety, immigration enforcement, and the limits of federal authority. Michael examines the legal standards governing ICE vehicle stops, the political fallout inside the Trump administration, and the larger unresolved question of what should happen to undocumented immigrants already living and working in the United States. He also explores why these cases have become a flashpoint in the broader immigration debate. Lijsten here, then vote, and be sure to RATE, REVIEW, and SHARE this podcast. Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

Vehicle stops

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#436 In this podcast episode, Guy talked with listeners about the importance of mastering "world-class basics" instead of getting lost in external noise, distraction, and fear-based conversations about the future. He explained five foundations of a self-respecting life: creating space, guarding inputs, caring for the body, living by personal values, and staying open to growth. Guy shared how meditation, silence, gratitude, nature, healthy relationships, quality sleep, nutrition, movement, hydration, sunlight, and integrity had helped him align his life with his heart and soul. He also emphasized that people needed to protect what entered their mind, environment, and body because those inputs shaped their choices, nervous system, and overall way of being. By the end, he encouraged listeners to reflect on whether their daily lives truly matched what they said they believed and to stay humble, curious, and open to what life was trying to teach them. ====================  Guy's Official Partners  The DNA Company – Get 10% Off https://thednacompany.com/letitinpodcast  FLFE – 2 Week Free Trial (No Credit Card Required) https://www.flfe.net/rp-affiliates.php?p=LiveInFlow&w=TryFLFEfree ====================  Key Points Discussed:  (00:00) - I've Never Been More Protective of My Energy! (00:42) - Why AI, Disclosure and "Earth Splitting" Can Become Spiritual Noise (01:36) - The "World-Class Basics" That Matter More Than Big Ideas (02:25) - Foundation 1: Create Space Before Life Becomes a Blur (03:10) - How to Become the Observer Instead of the Overwhelmed One (04:04) - Meditation, Breathwork and Gratitude as Daily Non-Negotiables (05:31) - What Happens When You Sit in Silence With No Inputs (06:28) - The Question That Reveals Whether You Can Actually Hear Yourself (06:43) - Foundation 2: Guard the Inputs Programming Your Mind (07:17) - The Wealth Advice That Made Him Turn His TV to the Wall (08:15) - The People Around You Are Either Feeding Your Life or Draining It (10:08) - How Your Environment Quietly Shapes Your Energy (11:41) - The Simple Test: Is This Feeding My Life or Draining It? (12:05) - Foundation 3: Treat Your Body Like the Vehicle of Your Life (13:05) - Why Sleep Became One of His Most Important Health Priorities (14:18) - DNA, Gut Health, Movement and the Data Behind Better Choices (16:25) - Water, Sunlight and Hormesis: The Basics Most People Ignore (18:52) - Foundation 4: Live Your Values When Life Pressures You (24:00) - Foundation 5: Stay Open Before Your Growth Starts Closing Down (30:55) - LIVE IN FLOW — Experience This Work in Person ==================== Guy's Offerings  www.liveinflow.co ====================  Listen on Podcast Spotify Apple Podcasts ====================  Connect with Guy Instagram www.instagram.com/guyhlawrence Live In Flow www.instagram.com/live.in.flow ====================  Continue Your Journey Explore Guy's complete collection of solo podcast episodes: www.youtube.com/show/VLPLKOgPYwzskDo?sbp=Kgt1clRBdHJGem9pd0AB

In the biotech industry, advancing cell-based therapies is not just about innovation. It's about solving real gaps where conventional treatments fall short, especially against complex, aggressive tumors.In this episode of the Smart Biotech Scientist Podcast, host David Brühlmann welcomes Jun Yung Woo, Co-Founder of AGEM Bio, who offers an in-depth look at the science and strategy behind engineered mesenchymal stem cells (MSCs), with a focus on why glioblastoma is the right proving ground for the platform.Topics discussed:Why glioblastoma is the right Phase I indication: infiltrative growth, immunosuppression, and STING pathway deficiencies that make GBM uniquely suited to the platform (02:43)The surgical workflow: intracavity MSC delivery during tumor resection, oral 5-FC administration, and how engineered cells act as local bioreactors in the resection cavity (04:05)Mechanisms by which engineered MSCs target heterogeneous and invasive tumors through shared vulnerabilities rather than antigen recognition (05:58)Overcoming immune rejection with allogeneic therapies and the unique immunological profile of MSCs (07:32)Manufacturing and scale-up: addressing donor variability, GMP production, and building a reproducible process (09:16)Why GMP manufacturing should be designed in from the earliest stages of research (10:50)Beyond glioblastoma: expanding the platform to other solid tumors, regenerative medicine, and chronic inflammatory disease (11:27)Strategies for international trial expansion and partnerships beyond Singapore (12:41)Reframing MSCs from stem cell therapy to programmable delivery platform: the MSC 2.0 thesis (14:10)Smart insight: The shift Jun Yung articulates is from treating stem cells as the therapy to treating them as programmable therapeutic vehicles. Once you can reliably engineer, manufacture, and preserve their function, the limitation is no longer what the cell naturally does. It becomes what biology you can encode into it. Glioblastoma is the proving ground, and the platform's reach extends to liver cancers, sarcomas, peritoneal malignancies, and chronic inflammatory disease.These episodes expand on the same themes of MSC biology, cell engineering, and the challenges of scaling consistent, functional cell therapies:Episodes 179 - 180 : How Mesenchymal Stromal Cells Are Transforming Care for Diabetes and Autoimmune Diseases with Lindsay DaviesEpisodes 253 - 254: How to Source, Manufacture, and Scale the Earliest Stem Cells for Allogeneic Cell Therapy Without Ethical Barriers with Yuta LeeEpisodes 125 - 126: How to Enhance Cell Engineering Using Mechanical Intracellular Delivery with Armon ShareiEpisodes 129 - 130: Revolutionizing Cell Therapy Manufacturing: Reducing Costs to Reach More Patients with Jason FosterConnect with Jun Yung Woo:LinkedIn: www.linkedin.com/in/junyungwooAGEM Bio website: www.agem.bioEmail: yung@agem.bioSupport the show

This week on the RPGBOT.Podcast, the hosts ask the eternal tabletop question: what happens when your beloved fantasy RPG grows up, gets a driver's license, discovers firearms, and immediately becomes everyone's problem? We begin with PishPash My Memory is Trash merch, accidental mug design crimes, Pride, wizard bazookas, and Ash's long-simmering legal case against the movie Bright. Then we get to the real issue: how do you let someone fight Tiamat with an Uzi without turning your campaign into a spreadsheet, a war crime, or Shadowrun with the serial numbers filed off? Show Notes In this episode, the RPGBOT crew takes a deep dive into adapting fantasy tabletop RPG systems like D&D and Pathfinder to other technology levels, including modern fantasy, science fiction, cyberpunk-adjacent worlds, post-apocalyptic settings, and anything else where a greatsword might have to share table space with a grenade launcher. Tyler walks through the history of previous attempts to drag D&D-style mechanics out of the dungeon and into other genres, including d20 Star Wars, d20 Modern, Star Wars Saga Edition, Star Wars 5e, and the often-forgotten Modern Magic Unearthed Arcana. Along the way, the hosts dig into how those systems handled things like armor, hit points, wounds, vitality, class design, talents, occupations, reputation, and the eternal question of whether getting shot with a blaster should feel worse than being poked with a longsword. The conversation turns into a practical design checklist for anyone trying to run fantasy rules in a modern or sci-fi setting. The big issues are weapons, armor, hit points, movement, vehicles, skills, tools, hacking, currency, magic, classes, monsters, and access to dangerous gear. A gun that does more damage than a sword is easy to write down. Making that gun fun, balanced, available, expensive, illegal, scary, and not immediately campaign-breaking is the actual work. The hosts also wrestle with the big philosophical question: at what point have you changed D&D so much that you should just play a different game? Tyler's rule of changing three major things makes its return, Ash argues for fantasy with modern aesthetics, Randall brings up comet-based magic awakenings and Maximum Overdrive, and everyone briefly imagines what happens when a party of adventurers has to fight a kaiju from inside a tank. Finally, the Question of the Week asks the most important dice-related question possible: what is your favorite die, and which one deserves to be thrown into the sea? Ash defends the d8 and declares war on the foot-stabbing d4. Tyler gives some love to the underappreciated d12. Randall hates the actual d100 because it is basically a tiny chaotic bowling ball that refuses to stop rolling. D20 Modern on DMsGuild (affiliate link) D20 Future on DMsGuild (affiliate link) SW5e Bright RPGBOT.Store DnD 5e modern rules UA "Modern Magic" Dan Helmick's update IMDB Maximum Overdrive Dimension 20: A Starstruck Odyssey Dice Miner (affiliate link) Key Takeaways Adapting fantasy RPGs to modern or sci-fi settings is not just about adding guns. You have to rethink combat assumptions, armor, hit points, movement, skills, equipment, enemies, and the economy. Previous d20-based games offer useful examples. d20 Star Wars experimented with wounds and vitality. d20 Modern used basic classes tied to ability scores, occupations, talents, and advanced classes. Star Wars Saga Edition showed some early design DNA that later appeared in 4e. Firearms and modern weapons change the math quickly. A pistol, rifle, grenade, or blaster can make traditional fantasy damage assumptions look very strange unless the system accounts for armor, accuracy, availability, legality, and consequences. Armor may need to work differently. In a modern game, characters probably are not walking around in plate armor, so armor might reduce damage, resist ballistic attacks, or be replaced partly by class-based defense or plot-armor-style scaling. Hit points can still work, but they need a clear interpretation. They might represent luck, stamina, near misses, tactical positioning, or cinematic survival rather than literal meat points. Vehicles change encounter design. Horses and overland travel are one thing. Cars, motorcycles, tanks, aircraft, and spaceships make movement, chase scenes, distance, and random encounters much more complicated. Skills and tools need updating. Computers, hacking, piloting, driving, engineering, and modern medicine may need to be skills, tool proficiencies, lore-style specialties, or full subsystems depending on how important they are to the campaign. The modern world makes Strength harder to justify unless the game gives it a reason to matter. Close quarters, carrying capacity, melee restrictions, grappling, armor, and specialized builds can help keep strong characters relevant. Classes may need reskinning rather than replacement. A barbarian might become a super-soldier, a rage-serum bruiser, or a minigun-wielding menace. A cleric might serve an ideal, philosophy, cosmic force, AI god, or belief system rather than a traditional deity. Magic can stay magical, become technology, or sit beside technology. Fireball might still be a spell, or it might be a grenade, a rocket launcher, a plasma weapon, or a problem for your insurance provider. Monsters still work if you treat them thoughtfully. Vampires, mind flayers, zombies, kaiju, and the Tarrasque can all survive in modern settings if their defenses, tactics, environment, and narrative role make sense. Access matters. Just because tanks, RPGs, and military hardware exist does not mean the party can buy them at Fantasy Costco. Price, legality, scarcity, black markets, and consequences are balancing tools. Currency may be better handled abstractly. Modern money can become tedious fast, so a wealth stat or resource system may work better than tracking every nickel, dime, credit card, crypto wallet, and suspicious suitcase full of cash. Tyler's three-change rule is a useful warning sign. If you need to make three huge changes to force D&D into another genre, consider whether another RPG already does what you want better. The episode's greatest lesson may be this: you can absolutely kill Tiamat with an Uzi, but first you need to know what that does to armor class, encounter balance, campaign tone, and the local black market. Welcome to the RPGBOT Podcast. If you love Dungeons & Dragons, Pathfinder, and tabletop RPGs, this is the podcast for you. Support the show for free: Rate and review us on Apple Podcasts, Spotify, or any podcast app. It helps new listeners find the best RPG podcast for D&D and Pathfinder players. Level up your experience: Join us on Patreon to unlock ad-free access to RPGBOT.net and the RPGBOT Podcast, chat with us and the community on the RPGBOT Discord, and jump into live-streamed RPG podcast recordings. Support while you shop: Use our Amazon affiliate link at https://amzn.to/3NwElxQ and help us keep building tools and guides for the RPG community. Meet the Hosts Tyler Kamstra – Master of mechanics, seeing the Pathfinder action economy like Neo in the Matrix. Randall James – Lore buff and technologist, always ready to debate which Lord of the Rings edition reigns supreme. Ash Ely – Resident cynic, chaos agent, and AI's worst nightmare, bringing pure table-flipping RPG podcast energy. Join the RPGBOT team where fantasy roleplaying meets real strategy, sarcasm, and community chaos. How to Find Us: In-depth articles, guides, handbooks, reviews, news on Tabletop Role Playing at RPGBOT.net Tyler Kamstra BlueSky: @rpgbot.net TikTok: @RPGBOTDOTNET Ash Ely Professional Game Master on StartPlaying.Games BlueSky: @GravenAshes YouTube: @ashravenmedia Randall James BlueSky: @GrimoireRPG Amateurjack.com Read Melancon: A Grimoire Tale (affiliate link) Producer Dan @Lzr_illuminati

President Trump personally reversed DHS' pause on ICE vehicle stops following backlash from MAGA-aligned figures, reportedly blindsiding senior officials. Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

Thu, Jul 16 10:51 PM → 10:51 PM bartonville finest Radio Systems: - Peoria Metro Area Site 2-49

Ottawa says it will spend almost $2 billion over four years on 190 armoured combat support vehicles that will be built by a Canada-based company. Power & Politics hears from Secretary of State for Defence Procurement Stephen Fuhr. Plus, U.S. Trade Representative Jamieson Greer says he hasn't 'seen a lot of movement' from Canada in trade talks. The Power Panel weighs in.

A used car can look perfect under the lights and still come with a past you did not sign up for. We bring in Patrick Olsen, editor-in-chief at Carfax, to break down what a Carfax vehicle history report actually reveals, why “Show me the Carfax” became shorthand for transparency, and how shoppers can use VIN-based data to negotiate with confidence.We talk about the real-world mechanics behind vehicle history reporting: what service shops and dealerships share, why DIY maintenance and small repairs can create gaps, and how the free Carfax Car Care app lets owners track maintenance and get recall alerts. Patrick also explains newer tools that go beyond the past, including history-based values, reliability predictions for specific vehicles, and dependability research that shows how many models survive to 150,000 miles, 200,000 miles, and even 20 years on the road. If you're comparing a regular used car to a certified pre-owned vehicle, we dig into why “CPO” can mean different things depending on the automaker and the dealer, and why documentation is everything.Then we shift gears: Jeff shares wild global car facts in Motor Minute, and Don delivers a detailed review of the 2025 Land Rover Range Rover plug-in hybrid, covering design, interior simplicity, power, ride quality, pricing, and key competitors like the BMW X5 PHEV and Mercedes GLE PHEV.Subscribe for more straight-talk car buying advice, share this with a friend shopping used, and leave a review so more drivers can find us.Be sure to subscribe for more In Wheel Time Car Talk!The Lupe' Tortilla RestaurantsLupe Tortilla in Katy, Texas Gulf Coast Auto ShieldPaint protection, tint, and more!Disclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.----  ----- Want more In Wheel Time car talk any time?     In Wheel Time is now available on Audacy!  Just go to Audacy.com/InWheelTime where ever you are.-----   -----Be sure to subscribe on your favorite podcast provider for the next episode of In Wheel Time Podcast and check out our live multiplatform broadcast every Saturday, 10a - 12nCT simulcasting on Audacy, YouTube, Facebook, Twitter, Twitch and InWheelTime.com.In Wheel Time Podcast can be heard on you mobile device from providers such as:Apple Podcasts, Amazon Music Podcast, Spotify, SiriusXM Podcast, iHeartRadio podcast, TuneIn + Alexa, Podcast Addict, Castro, Castbox, YouTube Podcast and more on your mobile device.Follow InWheelTime.com for the latest updates!Twitter: https://twitter.com/InWheelTimeInstagram: https://www.instagram.com/inwheeltime/https://www.youtube.com/inwheeltimehttps://www.Facebook.com/InWheelTimeFor more information about In Wheel Time Podcast, email us at info@inwheeltime.com

July 16, 2026 ~ Justine Nestorowich, Lincoln Vehicle Harmony Engineer joins Paul W. Smith live from Ford's World Headquarters. Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

Acting Attorney General Todd Blanche will be on Capitol Hill today for his high-stakes confirmation hearing to lead the Justice Department permanently. President Trump has talked about the US fully controlling the Strait of Hormuz. But for the US military that means much more than imposing yet another blockade on the key waterway. The third fatal ICE shooting in a week is now prompting a policy shift at the agency. According to Senator Angus King, ICE will now suspend most vehicle stops during enforcement operations.Want more analysis of the most important news of the day, plus a little fun? Subscribe to the Up First newsletter.Today's episode of Up First was edited by Andrew Sussman, Anna Yukhananov, Alina Hartounian, Mohamad ElBardicy, Alice Woelfle, and Ziad Buchh.It was produced by Paige Waterhouse and Nia Dumas.Our director is Christopher Thomas.We get engineering support from Neisha Heinis. Our technical director is Carleigh Strange.And our Supervising Producer is Michael Lipkin.(0:00) Introduction(1:49) Blanche confirmation hearing(5:38) US and the Strait of Hormuz(9:32) ICE Vehicle stopsSee pcm.adswizz.com for information about our collection and use of personal data for sponsorship and to manage your podcast sponsorship preferences.NPR Privacy Policy

ICE agents have been told to immediately scale back vehicle stops, sources say, in the wake of deadly shootings. Supreme Court justices ask Congress for security funding amid threats to their safety. And African migrants are being dispatched to the front lines in Russia's war against Ukraine.  AP Photo/Robert F. Bukaty  Learn more about your ad choices. Visit podcastchoices.com/adchoices

For more coverage on the issues that matter to you, download the WMAL app, visit WMAL.com or tune in live on WMAL-FM 105.9 from 9:00am-12:00pm Monday-Friday  To join the conversation, check us out on Twitter @WMAL and @ChrisPlanteShow Learn more about your ad choices. Visit podcastchoices.com/adchoices

Hello and welcome to Handgun Radio! I'm your host Ryan Michad, Weerd Beard & Co from the wild woods of Central Maine and this is your home for all the news, information and discussion in the handgunning world!   This week we talk Vehicle “Carry” & Least Bad Vehicle Firearm Storage!   Please check out […]

Hello and welcome to Handgun Radio! I'm your host Ryan Michad, Weerd Beard & Co from the wild woods of Central Maine and this is your home for all the news, information and discussion in the handgunning world!   This week we talk Vehicle “Carry” & Least Bad Vehicle Firearm Storage!   Please check out the Patriot Patch Company for their awesome patches and other high quality  items! Visit www.patriotpatch.co for more information! Cool artist “proof” rendition come along with the latest patch of the month patches!    Thank you to all our patreons! Visit us at https://www.patreon.com/handgunradio    Week In Review:   Ryan:  -Airsoft Thompson -Played my first gig in awhile -Potatoes are growing well in the buckets!   Weerd:   Xander: Ultimate baking fail Wheat harvest   Oddball -Bersa M2XI range report -upgrading Beretta 92 Brigadier   Drink Segment:   Main Topic: Vehicle “Carry” & Least Bad Vehicle Storage   -Methods -Glovebox Carry (NOOOO!) -Car carry is just bad in general. You can't access it when its needed. It happens NOW! Weerd– how does a shoulder holster work for this? -Risks -Theft -Liability if firearm is stolen & used in a crime   -Security  -Locking the case to a hard point in the car. -Considerations for our trip to TN without a trunk (Driving a Chrysler Pacifica 7 Person Van)   -Liability - Improper storage -Contributing to the delinquency of a minor -Felony Murder   Wrap Up: Don't forget to shop Brownells using our affiliate link! Head to firearmsradio.net and click the affiliate link in the upper right hand corner! Be sure to go like Handgun Radio on facebook and share it with your friends! Leave us a review on iTunes! Listen to all the great shows on the Firearms Radio Network! Check out the Patriot Patch Company!! www.patriotpatch.co   Weerd where can people find you? Assorted Calibers Podcast,  Weer'd World   Oddball gunscarstech.com Assorted Calibers Podcast ACP and HGR Facebook Play screechingtires.wav   David Assorted Calibers Podcast ACP and HGR Facebook Blue Collar Prepping Brena Bock Author Page David Bock Author Page Team And More Xander: Assorted Calibers Podcast Here so Ryan doesn't do a bad impression of me Play Smoke inhalation.wav   Until next week, have fun & safe shooting!  

Mike and Mark look at concerns over Supreme Court security, react to the pause in ICE vehicle stops after the Maine shooting, and compare notes over distractions and multitasking from the world of phones to the world of talk shows. ------ M and M EXTRA: Two iconic talk radio hosts. One unfiltered daily conversation. No scripts. No spin. Just Mike Gallagher and Mark Davis breaking down the news the way it should be — with decades of experience and zero apologies. If you love smart unscripted talk show chemistry, you’re in the right place. See omnystudio.com/listener for privacy information.

U.S. President Donald Trump scraps his Strait of Hormuz toll threat, saying he's opting for Gulf trade deals instead. ICE suspends most traffic stops after two fatal shootings in less than a week. Ukraine faces another wartime government reshuffle. Two U.S. Supreme Court justices make a rare appearance on the Hill to warn of threats against the court. And Spain dominates over France to reach the World Cup final. Listen to the Morning Bid podcast ⁠⁠here⁠⁠. Sign up for the Reuters Econ World newsletter ⁠⁠here⁠⁠. Listen to the Reuters Econ World podcast ⁠⁠here⁠⁠. Visit the Thomson Reuters Privacy Statement for information on our privacy and data protection practices. You may also visit megaphone.fm/adchoices to opt out of targeted advertising. Learn more about your ad choices. Visit megaphone.fm/adchoices

Mike and Mark look at concerns over Supreme Court security, react to the pause in ICE vehicle stops after the Maine shooting, and compare notes over distractions and multitasking from the world of phones to the world of talk shows. ------ M and M EXTRA: Two iconic talk radio hosts. One unfiltered daily conversation. No scripts. No spin. Just Mike Gallagher and Mark Davis breaking down the news the way it should be — with decades of experience and zero apologies. If you love smart unscripted talk show chemistry, you’re in the right place. See omnystudio.com/listener for privacy information.

Today's top stories, with context, in just 15 minutes.On today's podcast:1) President Trump said he would intensify the US's bombardment against Iran until it stops attacking ships in the Strait of Hormuz and agrees to open the waterway. A US-Iran interim peace deal signed around a month ago has all but collapsed over the past week as the two sides feud over control of the vital strait. Trump pledged to bomb Iran again and continue until Iran relents, saying energy targets in Iran will be left "for last".2) The Department of Homeland Security has ordered immigration agents to temporarily halt most vehicle stops during deportation operations after a fatal shooting in Maine. US Immigration and Customs Enforcement agents will suspend vehicle stops except for those targeting serious criminal cases until ICE officers receive new training on vehicle stops. The policy change comes after the second fatal shooting by immigration agents in a week, with the first being the fatal shooting of a Mexican construction worker during a traffic stop in Houston.3) Acting Attorney General Todd Blanche is set to appear before the US Senate in support of his nomination to lead the Justice Department. A federal judge in Miami issued harsh criticism of Blanche's actions in settling President Donald Trump's lawsuit against the Internal Revenue Service, suggesting his involvement raised conflict of interest concerns. The Justice Department's settlement with the president has faced rare GOP pushback, and Blanche is expected to be grilled about the settlement and other politically explosive matters during his nomination hearing.See omnystudio.com/listener for privacy information.

Tuesday, July 14, 2026 Today, Trump will give a Thursday night address likely to produce falsified evidence of foreign interference in the 2020 election; a federal judge has sanctioned two lawyers and referred Blanche and Woodward to the Bar for disciplinary action after finding Donald's lawsuit against the IRS was a fraud on the court; the Justice Department has finally turned over evidence in the shooting case of Renée Good by ICE agent Jonathan Ross in Minneapolis; 12 states have filed a lawsuit to block the Paramount Skydance and Warner Bros. merger; the Governor of South Carolina has appointed Lindsey Graham's sister to take over his Senate seat for the remainder of the term; ICE agents have killed another person in a vehicle in Biddeford Maine sparking protests at Susan Collins' office; 20 agents from the FBI and other federal agencies were seen with U.S. Capitol Police officers entering Lindsey Graham's house; Katie Phang fires back at Todd Blanche's refusal to release court-ordered Epstein documents; plus Allison delivers your Good News. The Daily Beans is proud to partner with Miles Taylor and our friends at DEFIANCE.org For a limited time, members of the Daily Beans community can receive a FREE 3-month full membership to DEFIANCE.org and gain access to one of the fastest-growing pro-democracy movements in America. Join here: https://www.defiance.org/beans   Thank You, HoneyLove Save 20% Off Honeylove by going to honeylove.com/DAILYBEANS #honeylovepod  #sponsored Thank You, OneSkin Get 15% off OneSkin with the code DAILYBEANS at  https://www.oneskin.co/dailybeans #oneskinpod #ad   Join The Daily Beans and give a gift today to ensure The Trevor Project can continue its crucial work in the face of continued challenges. Donate to The Trevor Project - Daily Beans Podcast The Latest Breakdown:BREAKING: EXCLUSIVE: FBI Admits it has Epstein Files Training Videos StoriesTrump election task force to begin releasing classified intel documents | MS NOW Trump Had Role in Weighing Proposals to Seize Voting Machines | The New York Times Trump administration tried to ‘manipulate the judicial process' with its IRS settlement, judge says | NBC News Fractures emerge after feds share evidence from Good, Pretti killings with Minnesota authorities | Minnesota Star Tribune 12 states file lawsuit to block $110 billion Paramount-Warner Bros. merger | NBC News Lindsey Graham's sister picked to serve the rest of his Senate term | The Washington Post FBI agents search Sen. Graham's DC home | NBC News ICE Agent Kills Person in Vehicle in Biddeford, Maine, State Officials Say | The New York TimesGood TroubleOppose Todd Blanche for Attorney General ⭑ 5 Calls →Urge Democrats to Oppose and Stop Trump's Crypto Corruption | Indivisible Guide →Defiance.org/beans →Show up for our Libraries - action.ala.org →goodtroubleliveson.org/ July 17-19 →How to help those impacted by the Venezuela earthquakes|AP →Oppose House Amendment to Defund the Peace Corps! →Stand With Minnesota →ICE List  →iceout.org Good Newsdana-goldbergs-southwest-funnyfest Oct 9 -Email Dana@DanaGoldberg.com for sponsorship information Tour - DANA GOLDBERGTickets for Dana Goldberg: Outrageous - Sep 23 - Den Theater - Chicago  →Share your Good News & Good Trouble - The Daily Beans →Beans Talk audio -beans-talk.simplecast.com →Email Dana LGBTQ Owned eating establishments in your area - hello@mswmedia.com Subject: “Dana's Project” Subscribe to the MSW YouTube Channel - MSW Media - YouTube Our Donation Links The Trevor Project - trevorproject.org/beans Blue Wave California - https://secure.actblue.com/donate/msw-bwc Donate to Public Citizen - https://citizen.org/beans/ Donate to It Gets Better / The Daily Beans Fundraiser Pathways to Citizenship link to MATCH Allison's Donationhttps://crm.bloomerang.co/HostedDonation?ApiKey=pub_86ff5236-dd26-11ec-b5ee-066e3d38bc77&WidgetId=6388736 Join Dana and The Daily Beans in support of Human Rights Campaign http://onecau.se/_ekes71 More Donation LinksNational Security Counselors - Donate, ActBlue.com/donate/msw-bwc, WhistleblowerAid.org/beans Dr. Allison Gill - The Breakdown | Allison Gill, Mueller, She Wrote @muellershewrote.com - Bluesky, MSW & The Daily Beans Podcast @muellershewrote - Instagram, MSW Media - YouTube →Federal workers - email AG at fedoath@pm.me and let me know what you're going to do, or just vent. I'm always here to listen.  Dana Goldberg - Dana is on Patreon! At Dana's Dugout, @dgcomedy - Bluesky, @dgcomedy - IG, Dana Goldberg - Facebook,  DanaGoldberg.com More from MSW Media - Shows - MSW Media, Cleanup On Aisle 45 pod, The Breakdown | Allison Gill Reminder - you can see the pod pics if you become a Patron. The good news pics are at the bottom of the show notes of each Patreon episode! That's just one of the perks of subscribing! patreon.com/muellershewrote Listener Survey:http://survey.podtrac.com/start-survey.aspx?pubid=BffJOlI7qQcF&ver=shortFollow the Podcast on Apple:https://apple.co/3XNx7ckWant to support the show and get it ad-free and early?https://patreon.com/thedailybeanshttps://dailybeans.supercast.com/https://apple.co/3UKzKt0 Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Hawk connects the killings to the legal warning from his previous video, that murder and assault are state charges a president cannot pardon, and to a Fourth Amendment argument about race-based stops, referencing an MSNBC segment and New York Times writer Mara Gay. He also previews Trump's Thursday prime time speech on the 2020 election, noting the lapsed federal statutes of limitations, and Dan Abrams on the SAVE Act. He then covers the Michigan Senate primary, where AIPAC-backed Haley Stevens faces Abdul El-Sayed for Gary Peters' open seat and is being mocked over a viral clip, before closing on good news: Trump has finally paid E. Jean Carroll the 5.6 million dollar judgment after exhausting his appeals. SUPPORT & CONNECT WITH HAWK- Support on Patreon: https://www.patreon.com/mdg650hawk - Hawk's Merch Store: https://hawkmerchstore.com - Connect on TikTok: https://www.tiktok.com/@mdg650hawk7thacct - Connect on TikTok: https://www.tiktok.com/@hawkeyewhackamole - Connect on BlueSky: https://bsky.app/profile/mdg650hawk.bsky.social - Connect on Substack: https://mdg650hawk.substack.com - Connect on Facebook: https://www.facebook.com/hawkpodcasts - Connect on Instagram: https://www.instagram.com/mdg650hawk - Connect on Twitch: https://www.twitch.tv/mdg650hawk ALL HAWK PODCASTS INFO- Additional Content Available Here: https://www.hawkpodcasts.comhttps://www.youtube.com/@hawkpodcasts- Listen to Hawk Podcasts On Your Favorite Platform:Spotify: https://spoti.fi/3RWeJfyApple Podcasts: https://apple.co/422GDuLYouTube: https://youtube.com/@hawkpodcastsiHeartRadio: https://ihr.fm/47vVBdPPandora: https://bit.ly/48COaTB

The death of a Maine man changed policies for the Department of Homeland Security. We bring you the latest on that, plus why the FBI searched Sen. Lindsey Graham's house after he died following a trip to Ukraine, and a warning about the heat as a 3-yeear-old dies in a hot car in Louisiana.

The death of a Maine man changed policies for the Department of Homeland Security. We bring you the latest on that, plus why the FBI searched Sen. Lindsey Graham's house after he died following a trip to Ukraine, and a warning about the heat as a 3-yeear-old dies in a hot car in Louisiana.

The death of a Maine man changed policies for the Department of Homeland Security. We bring you the latest on that, plus why the FBI searched Sen. Lindsey Graham's house after he died following a trip to Ukraine, and a warning about the heat as a 3-yeear-old dies in a hot car in Louisiana.

What if the answer to solid tumor therapy isn't about making immune cells smarter—but about rethinking what a therapeutic cell can do For years, mesenchymal stem cells (MSCs) have turned heads for their ability to home in on damaged tissue, yet their clinical utility has lagged behind the hype. What would it take to transform MSCs from passive healers into precision vehicles for next-generation cancer treatment?This week, David Brühlmann sits down with Jun Yung Woo, Co-Founder of AGEM Bio, who's devoted nearly two decades to decoding and reimagining the potential of MSCs. From engineering stress-resilient cells to pioneering dual-payload therapeutic platforms, Jun Yung Woo bridges fundamental biology and real-world clinical translation.Topics discussed:The case for understanding cell biology before focusing on process scale-up in bioprocessing (02:38)Jun Yung Woo's personal and scientific journey toward developing engineered MSC therapeutics (04:36)How MSCs sense their environment and exert therapeutic effects via secreted factors, rather than tissue replacement (08:28)Key differences between MSC therapies and immune cell therapies like CAR T cells (10:35)Overview of non-viral engineering platforms, and the importance of intracellular trafficking for modifying MSCs (12:23)Design of AGEM Bio's dual-payload MSC product (cytosine deaminase and interferon beta) to induce highly localized tumor stress and immune activation (14:10)Strategies for controlling MSC targeting and minimizing off-target effects, including the use of prodrug activation and localized cell delivery (17:23)Study results from treating companion animals with engineered MSCs, and observations of tumor regression and possible signs of immune memory (20:29)Open questions about the durability of antitumor responses and future directions for clinical research (22:34)Smart insight: Jun Yung Woo challenges the rush toward bioprocess scale-up, arguing that a deeper understanding of cellular biology should come before manufacturing cells at scale. This episode explores how scaling the wrong biology can derail entire therapeutic platforms—and why aligning process development with cellular function may be critical for clinical success.These episodes expand on the same themes of MSC biology, cell engineering, and the challenges of scaling consistent, functional cell therapies:Episodes 179 - 180 : How Mesenchymal Stromal Cells Are Transforming Care for Diabetes and Autoimmune Diseases with Lindsay DaviesEpisodes 253 - 254: How to Source, Manufacture, and Scale the Earliest Stem Cells for Allogeneic Cell Therapy Without Ethical Barriers with Yuta LeeEpisodes 125 - 126: How to Enhance Cell Engineering Using Mechanical Intracellular Delivery with Armon ShareiEpisodes 129 - 130: Revolutionizing Cell Therapy Manufacturing: Reducing Costs to Reach More Patients with Jason FosterConnect with Jun Yung Woo:LinkedIn: www.linkedin.com/in/junyungwooAGEM Bio website: www.agem.bioEmail: yung@agem.bioSupport the show

The death of a Maine man changed policies for the Department of Homeland Security. We bring you the latest on that, plus why the FBI searched Sen. Lindsey Graham's house after he died following a trip to Ukraine, and a warning about the heat as a 3-yeear-old dies in a hot car in Louisiana.

The Trump administration is ordering ICE to suspend most vehicle stops after two deadly shootings. AP's Lisa Dwyer reports.

In this episode we'll talk about:Why the endless revenue chase is a fallacy that keeps you from ever arrivingHow we accidentally made business the destination when it was always meant to be the vehicleWhy most of what you actually want probably costs less than what you've been trying to earnThe difference between chasing enjoyment and building for itHow to define what "enough" actually looks like for your lifeWhat becomes possible when business becomes fun againAnd more… START HERE…→ Join The Niche Is You® — my Substack (20K+) — Weekly essays, the full workshop library, the private community + the Quarterly Challenges. → https://mattgottesman.substack.com/aboutNEW HERE…→ 6 Days to Clarity Workshop — clarity for your time, energy, money, creativity, work & play. → https://mattgottesman.com/reverse-engineer-your-life (FREE)CONNECT WITH ME…→ Instagram — @mattgottesman→ TikTok — @mattgottesman→ YouTube — @mattgottesmanRESOURCES…→ Write • Design • Build — my Content Creator Studio & OS masterclass (Included when you join my Substack) — Growing the niche of you, your audience, reach, voice, passion & income — CLICK HERE→ Recommended Book List — CLICK HERE→ Apparel — thenicheisyou.comOTHER RELATED EPISODES:Faith Isn't Knowing the Whole Path… It's Taking the Next Honest StepApple: https://apple.co/3MB62IuSpotify: https://bit.ly/4rZw3RN

Private markets continue to evolve, and Special Purpose Vehicles (SPVs) have become one of the most important tools for investors seeking access to high-growth private companies. But behind every SPV is a complex legal and operational structure that many investors don't fully understand. In this episode, we sit down with Mitch Mechigian, an experienced private markets professional specializing in SPV management and venture investing. Mitch shares what happens behind the scenes of structuring, administering, and managing SPVs throughout their full lifecycle—from formation and investor onboarding to governance, reporting, distributions, and exits. Whether you're an angel investor, venture capitalist, founder, family office, or someone looking to better understand private market investing, this episode provides a practical look at how SPVs work, the risks investors should evaluate, and how the rapidly growing secondary market is changing access to private company investments. In This Episode Mitch's career journey into venture investing and SPV management What Special Purpose Vehicles (SPVs) are and why they're widely used Lessons learned from managing SPVs throughout their lifecycle Understanding counterparty risk and why it matters The difference between direct (first-layer) and indirect (second-layer) SPV investments Investor rights, reporting obligations, K-1s, and ongoing communications How share classes and liquidation preferences impact secondary pricing Navigating Rights of First Refusal (ROFR) in private company transactions Typical fee structures in SPVs and who pays them The future of venture secondaries and private market liquidity Key Takeaways SPVs provide efficient access to private investment opportunities but require careful structuring and administration. Investors should understand not only the underlying company but also the legal and economic structure of the SPV itself. Share class rights, governance provisions, and transfer restrictions can materially affect investment outcomes. As companies remain private longer, secondary markets and SPVs are becoming increasingly important components of the venture capital ecosystem. Understanding information rights, fees, and counterparty risk is essential before investing in any SPV. About Mitch Mechigian Mitch Mechigian is a private markets professional with extensive experience in venture investing, SPV administration, and private capital transactions. Throughout his career, he has worked with founders, investors, and fund managers to structure and manage investment vehicles that provide access to private companies while navigating the operational, legal, and reporting complexities of private market investing. Who Should Listen Angel Investors Venture Capital Investors Family Offices Startup Founders Investment Bankers Private Market Professionals Emerging Fund Managers Finance Students Anyone interested in venture capital and private market investing Disclaimer: The views expressed in this podcast are for informational purposes only. They do not constitute financial, investment, legal, or tax advice, nor do they necessarily reflect the views of Finalis Inc. or Finalis Securities LLC, Member FINRA/SIPC. Any discussion of private investments, securities, or investment strategies is general in nature and should not be relied upon as a recommendation or solicitation to buy or sell any security. Investors should conduct their own due diligence and consult their professional advisors before making any investment decisions. #PrivateMarkets #VentureCapital #SPV #Secondaries #StartupInvesting #PrivateEquity #AngelInvesting #SiliconValley #BusinessPodcast #TheSiliconValleyPodcast

Europe's new AI-powered vehicle safety rules require cars to monitor drivers' eye and head movements to detect distraction and fatigue, sparking debate over privacy, surveillance, and who controls driver data.