Podcasts about crispr cas

Synopsis: Host Rahul Chaturvedi welcomes back Rachel Haurwitz, President & CEO of Caribou Biosciences, for a deep dive into the future of CRISPR-based genome editing and its transformative impact on cell therapy. As a pioneer in the field, Rachel shares the evolution of off-the-shelf CAR T therapies and how Caribou Biosciences is tackling some of the biggest challenges in biotech. With four ongoing Phase 1 trials in lymphoma, multiple myeloma, AML, and lupus, Caribou is leading the charge in making CAR T therapies more scalable, accessible, and cost-effective. Rachel also discusses Caribou's journey from a private startup to a publicly traded company, the role of strategic partnerships like Pfizer's equity investment, and how biotech companies can navigate today's uncertain funding landscape. She reflects on lessons from co-founding Caribou at just 26, the evolution of biotech entrepreneurship, and why raising more capital than you think you need is crucial. Plus, she shares her perspective on leadership, industry trends, and the importance of diversity in biotech, as seen during JPMorgan's ‘Pink Tuesday' movement. From cutting-edge science to strategic decision-making, this episode is packed with insights for biotech professionals, investors, and anyone fascinated by the future of gene editing and cell therapy. Biography: Rachel is a co-founder of Caribou Biosciences and has been its president and chief executive officer and a director since the company's inception in 2011. Rachel is an inventor on patents and patent applications covering multiple CRISPR-based technologies, and has co-authored several scientific papers in high-impact journals characterizing CRISPR-Cas systems. In 2014, she was named by Forbes Magazine to the “30 Under 30” list in Science and Healthcare, and in 2016, Fortune Magazine named her to the “40 Under 40” list of the most influential young people in business. In 2018, the Association for Women in Science recognized Rachel with the annual Next Generation Award. She serves on the board of directors for Biotechnology Innovation Organization (BIO). Rachel earned an AB in biological sciences from Harvard College and a PhD in molecular and cell biology from the University of California, Berkeley.

在每一千名先天性聽損的新生兒中，約有二至四例由基因突變引起。遺傳性聽損尚無根治方法，現有的解決方案主要透過助聽器或人工電子耳來輔助聽力。隨著基因編輯技術的快速發展，越來越多科學家致力於研究遺傳性聽損的基因編輯治療，希望藉由修正突變基因來實現根治。本集節目邀請了目前在哈佛大學攻讀 Speech and Hearing Bioscience and Technology 博士班，並擔任 BTBA 新任共同會長之一的胡金儒（Ginnie Hu）與我們分享他的研究方向與心得。 節目最後，另一位 BTBA 共同會長羅維中博士（Jimmy Luo）會加入討論，聊聊他們與 BTBA 的淵源，以及對組織未來一年的規劃與展望。  

Crispr-Cas, le ciseau moléculaire, détruirait des portions entières du génome Les brèves du jour Grande invitée: Nelly Staderini, sage-femme Référente médicale chez Médecin Sans Frontières

In this episode of Molecule to Market, you'll go inside the outsourcing space of the global drug development sector with Akshay Peer, co-founder and Senior Vice President of Products at TrakCel. Your host, Raman Sehgal, discusses the pharmaceutical and biotechnology supply chain with Akshay, covering: How the development of a patent led him into the CGT space—years before it was a market The founding story of TrakCel and getting GSK as an anchor client to support early iterations of its custom solution Fresh-in, frozen-out... just one of the variations of biospecimens to product in the crazy complex CGT supply chain Standardizing, streamlining, and harmonizing will become the de facto software choice for the avalanche of CGTs predicted to be approved by 2030 The decision to seek strategic investors (instead of financial investors) and the advantages it has brought to TrakCel Akshay is a co-founder and currently serves as the Senior Vice President of Product at TrakCel. Before this, he worked as the Business Development Lead for TrakCel for 8 years, from 2012 to 2018. He then took a break and worked as the CGT lead for Bluecrux. After a two-year hiatus, Akshay rejoined TrakCel's team in September 2023 as the new head of product. He is an expert in software solutions to address the challenges of scaling cell and gene therapy products. Akshay has worked with companies developing autologous, allogeneic, CRISPR Cas-9, and other technology-based products.   This episode of Molecule to Market is sponsored by Vetter, a global leader in aseptic filling solutions for injectable products in the pharmaceutical and biotech industries. Discover more about Vetter's comprehensive services, from early-stage development to commercial production, and how they support clients in delivering high-quality therapies to the market.   Please subscribe, tell your industry colleagues and join us in celebrating and promoting the value and importance of the global life science outsourcing space. We'd also appreciate a positive rating!   Molecule to Market is sponsored and funded by ramarketing, an international marketing, design, digital and content agency helping companies differentiate, get noticed and grow in life sciences.

When I think of digital biology, I think of Patrick Hsu—he's the prototype, a rarified talent in both life and computer science, who recently led the team that discovered bridge RNAs, what may be considered CRISPR 3.0 for genome editing, and is building new generative A.I. models for life science. You might call them LLLMs-large language of life models. He is Co-Founder and a Core Investigator of the Arc Institute and Assistant Professor of Bioengineering and Deb Faculty Fellow at the University of California, Berkeley.Above is a brief snippet of our conversation. Full videos of all Ground Truths podcasts can be seen on YouTube here. The audios are also available on Apple and Spotify.Here's the transcript with links to the audio and external links to relevant papers and things we discussed.Eric Topol (00:06):Well hello, it's Eric Topol with Ground Truths and I'm really delighted to have with me today Patrick Hsu. Patrick is a co-founder and core investigator at the Arc Institute and he is also on the faculty at the University of California Berkeley. And he has been lighting things up in the world of genome editing and AI and we have a lot to talk about. So welcome, Patrick.Patrick Hsu (00:29):Thanks so much. I'm looking forward to it. Appreciate you having me on, Eric.The Arc InstituteEric Topol (00:33):Well, the first thing I'd like to get into, because you're into so many important things, but one that stands out of course is this Arc Institute with Patrick Collison who I guess if you can tell us a bit about how you two young guys got to meet and developed something that's really quite unique that I think brings together investigators at Stanford, UCSF, and Berkeley. Is that right? So maybe you can give us the skinny about you and Patrick and how all this got going.Patrick Hsu (01:05):Yeah, sure. That sounds great. So we started Arc with Patrick C and with Silvana Konermann, a longtime colleague and chemistry faculty at Stanford about three years ago now, though we've been physically operational just over two years and we're an independent research institute working at the interface of biomedical science and machine learning. And we have a few different aspects of our model, but our overall mission is to understand and treat complex human diseases. And we have three pillars to our model. We have this PI driven side of the house where we centrally fund our investigators so that they don't have to write grants and work on their very best ideas. We have a technical staff side of the house more like you'd see in a frontier AI lab or in biotech industry where we have professional teams of R&D scientists working cross-functionally on higher level organizational wide goals that we call our institute initiatives.(02:05):One focused on Alzheimer's disease experimentally and one that we call a virtual cell initiative to simulate human biology with AI foundation models. And our third pillar over time is to have things not just end up as academic papers, but really get things out into the real world as products or as medicines that can actually help patients on the translational side. And so, we thought that some really important scientific programs could be unlocked by enabling new organizational models and we are experimenting at the institutional scale with how we can better organize and incentivize and support scientists to reach these long-term capability breakthroughs.Patrick, Patrick and SilvanaEric Topol (02:52):So the two Patrick's. How did you, one Patrick I guess is a multi-billionaire from Stripe and then there's you who I suspect maybe not quite as wealthy as the other Patrick, how did you guys come together to do this extraordinary thing?Patrick Hsu (03:08):Yeah, no, science is certainly expensive. I met Patrick originally through Silvana actually. They actually met, so funny trivia, all three Arc founders did high school science together. Patrick and Silvana originally met in the European version of the European Young Scientist competition in high school. And Silvana and I met during our PhDs in her case at MIT and I was at Harvard, but we met at the Broad Institute sort of also a collaborative Harvard, MIT and Harvard hospitals Institute based in Kendall Square. And so, we sort of in various pairwise combinations known each other for decades and worked together for decades and have all collectively been really excited about science and technology and its potential to accelerate societal progress. Yet we also felt in our own ways that despite a lot of the tremendous progress, the structures in which we do this work, fund it, incentivize it and roll it out into the real world, seems like it's really possible that we'll undershoot that potential. And if you take 15 years ago, we didn't have the modern transformer that launched the current AI revolution, CRISPR technology, single-cell, mRNA technology or broadly addressable LNPs. That's a tremendous amount of technologies have developed in the next 15 years. We think there's a real unique opportunity for new institutes in the 2020s to take advantage of all of these breakthroughs and the new ones that are coming to continue to accelerate biological progress but do so in a way that's fast and flexible and really focused.Eric Topol (04:58):Yeah, I did want to talk with you a bit. First of all before I get to the next related topic, I get a kick out of you saying you've worked or known each other for decades because I think you're only in your early thirties. Is that right?Patrick Hsu (05:14):I was lucky to get an early start. I first started doing research at the local university when I was 14 actually, and I was homeschooled actually until college. And so, one of the funny things that you got to do when you're homeschooled is well, you could do whatever you want. And in my case that was work in the lab. And so, I actually worked basically full time as an intern volunteer, cut my teeth in single cell patch clamp, molecular biology, protein biochemistry, two photon and focal imaging and kind of spiraled from there. I loved the lab, I loved doing bench work. It was much more exciting to me than programming computers, which was what I was doing at the time. And I think these sort of two loves have kind of brought me and us to where we are today.Eric Topol (06:07):Before you got to Berkeley and Arc, I know you were at Broad Institute, but did you also pick up formal training in computer science and AI or is that something that was just part of the flow?Patrick Hsu (06:24):So I grew up coding. I used to work through problems sets before dinner growing up. And so, it's just something that you kind of learn natively just like learning French or Mandarin.New Models of Funding Life ScienceEric Topol (06:42):That's what I figured. Okay. Now this model of Arc Institute came along in a kind of similar timeframe as the Arena BioWorks in Boston, where some of the faculty left to go to Arena like my friend Stuart Schreiber and many others. And then of course Priscilla and Mark formed the Chan Zuckerberg Institute and its biohub and its support. So can you contrast for one, these three different models because they're both very different than of course the traditional NIH pathway, how Arc is similar or different to the others, and obviously the goal here is accelerating things that are going to really make a difference.Patrick Hsu (07:26):Yeah, the first thing I would say is zooming out. There have been lots of efforts to experiment with how we do science, the practice of science itself. And in fact, I've recently been reading this book, the Demon Under the Microscope about the history of infectious disease, and it talks about how in the 1910s through the 1930s, these German industrial dye manufacturing companies like Bayer and BASF actually launched what became essentially an early model for industrial scale science, where they were trying to develop Prontosil, Salvarsan and some of these early anti-infectives that targeted streptococcus. And these were some of the major breakthroughs that led to huge medical advances on tackling infectious disease compared to the more academic university bound model. So these trends of industrial versus academic labs and different structures to optimize breakthroughs and applications has been a through current throughout international science for the last century.(08:38):And so, the way that we do research today, and that's some of our core tenets at Arc is basically it hasn't always been this way. It doesn't need to necessarily be this way. And so, I think organizational experiments should really matter. And so, there's CZI, Altos, Arena, Calico, a variety of other organizational experiments and similarly we had MRC and Bell Labs and Xerox PARCS, NIBRT, GNF, Google Research, and so on. And so, I think there are lots of different ways that you can organize folks. I think at a high level you can think about ways that you can play with for-profit versus nonprofit structures. Whether you want to be a completely independent organization or if you want to be partnered with universities. If you want to be doing application driven science or really blue sky curiosity driven work. And I think also thinking through internally the types of expertise that you bring together.(09:42):You can think of it like a cancer institute maybe as a very vertically integrated model. You have folks working on all kinds of different areas surrounding oncology or immunotherapy and you might call that the Tower of Babel model. The other way that folks have built institutes, you might call the lily pad model where you have coverage of as many areas of biomedical research as possible. Places like the Whitehead or Salk, it will be very broad. You'll have planned epigenetics, folks looking at RNA structural biology, people studying yeast cell cycle, folks doing in vivo melanoma models. It's very broad and I think what we try to do at Arc is think about a model that you might liken more to overlapping Viking shields where there's sort of five core areas that we're deeply investing in, in genetics and genomics, computation, neuroscience, immunology and chemical biology. Now we really think of these as five areas that are maybe the minimal critical mass that you would need to make a dent on something as complicated as complex human diseases. It's certainly not the only thing that you need, but we needed a critical mass of investigators working at least in these areas.Eric Topol (11:05):Well, yeah, and they really converge on where the hottest advances are being made these days. Now can you work at Arc Institute without being one of these three universities or is it really that you maintain your faculty and your part of this other entity?Patrick Hsu (11:24):So we have a few elements to even just the academic side of the house. We have our core investigators. I'm one of them, where we have dually appointed faculty who retain their latter rank or tenured appointment in their home department, but their labs are physically cited at the Arc headquarters where we built out a lab in Stanford Research Park in Palo Alto. And so, folks move their labs there. They continue to train graduate students based on whatever graduate programs they're formally affiliated with through their university affiliation. And so, we have nearly 40 PhD students across our labs that are training on site every day.(12:03):So in addition to our core investigators, we also have what we call our innovation investigators, which is more of a grant program to faculty at our partner universities. They receive unrestricted funding from us to seed a new project or accelerate an existing area in their group and their labs stay at their home campus and they just get that funding to augment their work. The third way is our technical staff model where folks basically just come work at Arc and many of them also are establishing their own research groups focusing on technology R&D areas. And so, we have five of those technology centers working in molecular engineering, multi-omics, complex cellular models, in vivo models, and in machine learning.Discovery of Bridge RNAsEric Topol (12:54):Yeah, that's a great structure. In fact, just a few months ago, Patrick Collison, the other Patrick came to Stanford HAI where I'm on the board and you've summarized it really well and it's very different than the other models and other entities, companies included that you mentioned. It's really very impressive. Now speaking of impressive on June 26, this past few months ago, which incidentally is coincident with the draft genome in the year 2000, the human sequence. You and your colleagues, perhaps the most impressive jump in terms of an Arc Institute contribution published two papers back-to-back in Nature about bridge RNA: [Bridge RNAs direct programmable recombination of target and donor DNA] and [Structural mechanism of bridge RNA-guided recombination.] And before I get you to describe this breakthrough in genome editing, some would call it genome editing 3.0 or CRISPR 3.0, whatever. But what we have today in the clinic with the approval of CRISPR 1.0 for sickle cell and thalassemia is actually quite crude. I think most people will know it's just a double stranded DNA cleavage with all sorts of issues about repair and it's not very precise. And so, CRISPR 2.0 is supposed to be represented by David Liu's contributions and his efforts at Broad like prime and base editing and then comes yours. So maybe you can tell us about it and how it is has to be viewed as quite an important advance.Patrick Hsu (14:39):The first thing I would say before CRISPR, is that we had RNA interference. And so, even before this modern genome editing revolution with programmable CRISPRs, we had this technology that had a lot of the core selling points as well. Any target will now become druggable to us. We simply need to reprogram a guide RNA and we can get genetic access to things that are intracellular. And I think both the discovery of RNA interference by Craig Mello and Andy Fire or the invention or discovery of programmable CRISPR technologies, both depend on the same fundamental biological mechanism. These non-coding guide RNAs that are essentially a short RNA search string that you can easily reprogram to retarget a desired enzyme function, and natively both RNAi and CRISPR are molecular scissors. Their RNA or DNA nucleases that can be reprogrammed to different regions of the genome or the transcriptome to make a cut.(15:48):And as bioengineers, we have come up with all kinds of creative ways to leverage the ability to make site specific cuts to do all kinds of incredible things including genome editing or beyond transcriptional up or down regulation, molecular imaging and so on and so forth. And so, the first thing that we started thinking about in our lab was, why would mother nature have stopped only RNAi and CRISPR? There probably are lots of other non-coding RNAs out there that might be able to be programmable and if they did exist, they probably also do more complicated and interesting things than just guide a molecular scissors. So that was sort of the first core kind of intuition that we had. The second intuition that we had on the technology side, I was just wearing my biology hat, I'll put on my technology hat, is the thing that we call genome editing today hardly involves the genome.(16:50):It's really you're making a cut to change an individual base or an individual gene or locus. So really you're doing small scale single locus editing, so you might call it gene level or locus level cuts. And what you really want to be able to do is do things at the genome scale at 100 kb, a megabase at the chromosome scale. And I think that's where I think the field will inevitably go if you follow the technology curves of longer and longer range gene sequencing, longer and longer range gene synthesis, and then longer and longer range gene editing. And so, what would that look like? And we started thinking, could there be essentially recombination technologies that allow you to do cut and paste in a single step. Now, the reason for that is the way that we do gene editing today involves a cut and then a multi-step process of cellular DNA repair that resolves the cut to make the exertion or the error prone deletion or the modification that ends up happening.(17:59):And so, it's very complicated and whether that's nucleases or base or prime editing, you're all generally limited to the small-scale single locus changes. However, there are natural mechanisms that have solved this cut and paste problem, right? There are these viruses or bacterial versions of viruses known as phage that have generally been trying to exert their multi kilobase genomes into bacterial hosts and specialize throughout billions of years. So our core thought was, well, if there are these new non-coding RNAs, what kind of functions would we be excited about? Can we look in these mobile genetic elements, these so-called jumping genes for new mechanisms? They're incredibly widespread. Transposons are thought to be some of the most diverse enzyme mechanisms found in nature. And so, we started computationally by asking ourselves a very simple question. If a mobile element inserts itself into foreign DNA and it's able to somehow be programmable, presumably the inside or something encoded in the inside of the element is predictive of some sequence on the outside of the element.(19:15):And so, that was the core insight we took, and we thought let's look across the boundaries of many different mobile genetic elements and we zoomed in on a particular sub family of these MGE known as insertion sequence (IS) elements which are the most autonomous minimal transposons. Normally transposons have all kinds of genes that they use to hitchhike around the genomic galaxy and endow the bacterial host with some fitness advantage like some ability to metabolize some copper and some host or some metal. And these IS elements have only the enzymes that they need to jump around. And if you identify the boundaries of these using modern computational methods, this is actually a really non-trivial problem. But if you solve that problem to figure out with nucleotide resolution where the element boundaries end and then you look for the open reading frame of the transposases enzyme inside of this element, you'll find that it's not just that coding sequence.(20:19):There are also these non-coding flanks inside of the element boundaries. And when we looked across the non-coding, the entire IS family tree, there are hundreds of these different types of elements. We found that this particular family IS110, had the longest non-coding ends of all IS elements. And we started doing experiments in the lab to try to figure out how these work. And what we found was that these elements are cut and paste elements, so they excise themselves into a circular form and paste themselves back in into a target site linearly. But the circularization of this element brings together two distal ends together, which brings together a -35 and a -10 box that create and reconstitute a canonical bacterial transcriptional promoter. This essentially is like plugging a plug into an electrical socket in the wall and it jacks up transcription. Now you would think this transcription would turn on the transposase enzyme so it can jump around more but it transcribes a non-coding RNA out of this non-coding end.(21:30):We're like, holy crap, are these RNAs actually involved in regulating the transposon? Now the boring answer would be, oh, it regulates the expression. It's like an antisense regulate or something. The exciting answer would be, oh, it's a new type of guide RNA and you found an RNA guided integrase. So we started zooming in bound dramatically on this and we undertook a covariation analysis where we were able to show that this cryptic non-coding RNA has a totally novel guide RNA structure, totally distinct from RNAi or CRISPR guide RNAs. And it had a target site that covaried with the target site of the element. And so we're like, oh wow, this could be a programmable transposase. The second thing that we found was even more surprising, there was a second region of complementarity in that same RNA that recognized the donor sequence, which is the circularized element itself. And so, this was the first example of a bispecific guide RNA, and also the first example of RNA guided self-recognition by a mobile genetic element.Eric Topol (22:39):It's pretty extraordinary because basically you did a systematic assessment of jumping genes or transposons and you found that they contain things that previously were not at all recognized. And then you have a way to program these to edit, change the genome without having to do any cuts or nicks, right?Patrick Hsu (23:05):Yeah. So what we showed in a test tube is when we took this, so-called bridge RNA, which we named because it bridges the target and donor together along with the recombinase enzyme. So the two component system, those are the only two things that you need. They're able to cut and paste DNA and recombine them in a test tube without any DNA repair, meaning that it's independent of cellular DNA repair and it does strand nicking, exchange, junction resolution and religation all in a single mechanism. So that's when we got super excited about its potential applications as bioengineering tool.Eric Topol (23:46):Yeah, it's pretty extraordinary. And have you already gone into in vivo assessment?Patrick Hsu (23:54):Yes, in our initial set of papers, what we showed is that these are programmable and functional or recombinases in a test tube and in bacterial cells. And by reprogramming the target and donor the right way, you can use these enzymes not just for insertion, but also for flipping and cutting out DNA. And so, we actually have in a single mechanism the ability to do bridge editing, if you will, for universal DNA recombination, insertion, excision or inversion, similar to what folks have been doing for decades with Cre recombinase, but with fully programmable recognition sequences. The work that we're doing now in the lab as you can imagine is to adapt these into robust tools for mammalian genome editing, including of course, human genomes. We're excited about this, we're making good progress. The CRISPR has had thousands of labs over the last 10, 15 years working on it to make these therapeutic level potency and selectivity. We're going to work and follow that same blueprint for getting bridge systems to get to that level of performance, but we're on the path and we're very optimistic for the future.Exemplar of Digital BiologyEric Topol (25:13):Yeah, I think it's quite extraordinary and it's a whole different look to what we've been seeing in the CRISPR era for over the past decade and how that's been advancing and getting more specific and less need for repair and being able to be more versatile. But this takes it to yet another dimension. Now, this brings me to the field that when I think of this term digital biology, I think of you and now our mutual acquaintance, Jensen Huang, who everybody knows now. Back some months ago, he wrote and said at a conference, “Where do I think the next amazing revolution is going to come? And this is going to be flat out one of the biggest ones ever. There's no question that digital biology is going to be it. For the first time in human history, biology has the opportunity to be engineering, not science.” So can you critique Jensen? Is he right? And tell us how you conceive the field of digital biology.Patrick Hsu (26:20):If you look at gene therapy today, the core concepts are actually remarkably simple. They're elegant. Of course, you're missing a broken gene, you need to put it back. And that can be curative. Very simple, powerful concept. However, for complex diseases where you don't have just a single gene that goes wrong, in many cases we actually have no idea what to do. And in fact, when you're trying to put in DNA, that's over more than a gene scale. We kind of very quickly run out of ideas. Is it a CAR and a cytokine, a CAR and a cytokine and another thing? And then we're kind of out of ideas. And so, we started thinking in the lab, how can we actually design genomes where it's not just let's reduce the genome into individual Lego blocks, iGem style with promoters and different genes that we just sort of shuffle the Lego blocks around, but actually use AI to design genome sequences.(27:29):So to do that, we thought we would have to first of all, train a model that can learn and decode the foreign language of biology and use that in order to design sequences. And so, we sort of have been training DNA foundation models and virtual cell models at Arc, sort of a major effort of ours where the first thing that we tried was to take a variance of transformer architecture that's used to train ChatGPT from OpenAI, but instead apply this to study the next DNA token, right? Now, the interesting thing about next token prediction in English is that you can actually learn a surprising amount of information by just predicting the next word. You can learn world knowledge is the capital of Azerbaijan, is it Baku or is it London, right? Or if you're walking around in the kitchen, then the next text is, I then left the kitchen or the bathroom, right?(28:33):Now you're learning about spatial reasoning, and so you can also learn translation obviously. And so similarly, I think predicting the next token or the next base and DNA can lead you to learn about molecular biochemistry, is the next amino acid residue, hydrophobic or hydrophilic. And it can teach you about the mechanics of some catalytic binding pocket or something. You can learn about a disease mutation. Is the next base, the sick linked base or the wild type base and so on and so forth. And what we found was that at massive scale, DNA foundation models learn about molecular function, not just at the DNA level, but also at the RNA and the protein. And indeed, we could use these to design molecular systems like CRISPR-Cas systems, where you have a protein and the guide RNA. It could also design new DNA transposons, and we could design sequences that look plausibly like real genomes, where we generate a megabase a million bases of continuous genome sequence. And it really looks and feels like it could be a blurry picture of something that you would actually sequence. This has been a wonderful collaboration with Brian Hie, a PI at Stanford and an Arc investigator, and we're really excited about what we've seen in this work because it promises the better performance with even more scale. And so, simply by scaling up these models, by adding in more compute, more training data or more powerful models, they're going to get sharper and sharper.New A.I. Models in Life ScienceEric Topol (30:25):Yeah. Well, this whole use of large language models for the language of life, whether it's the genome proteins and on and on, actually RNA and even cells has really taken root. And of course, this is really one of the foundations of that field of digital biology, which brings together generative AI, AI tools and trying to push forward our understanding in biology. And also, obviously what's been emphasized in drug discovery, perhaps it's been emphasized even too much because we still have a lot to learn about biology, but that gets me to these models. Like today, AlphaProteo was announced by DeepMind, as we all know, AlphaFold 1, 2, now 3. They were kind of precursors of being able to predict proteins from amino acid 3D structure. And that kind of took the field by a little bit like ChatGPT for life science, but now it's a new model all the time. So you've been working on various models and Arc Institute, how do you see this unfolding? Are we just going to have every aspect of the language of life being approached in all the different interactions? And this is going to help us get to a much more deep level of understanding.Patrick Hsu (31:56):I'll say two things. The first is a lot of models that you just described are what I would call task specific models. A model for de novo design of a binder, a model for protein structure prediction. And there are other models for protein fitness or for RNA structure prediction, et cetera, et cetera. And I think what we're going to move towards are more unifying models where there's different classes of models at different levels of scale. So we will have these atomic level models for looking at generative chemistry or ligand docking. We have models that can unify genomes and their molecules, and then we have models that can unify cells and tissues. And so, for example, if you took an H&E stain of some liver, there are folks building models where you can then predict what the single cell spatial transcriptome will look like of that model. And that's obviously operating at a very different level of abstraction than a de novo protein binder. But in the long run, all of these are going to get, I think unified. I think the reason why this is possible is that biology, unlike physics, actually has this unifying theory of evolution that runs across all of its length scales from atomic, molecular, cellular, organismal to entire ecosystem. And the promise of these models is no short then to make biology a predictive discipline.Patrick Hsu (33:37):In physics, the experimentalists win the big prizes for the theorists when they measure gravitational waves or whatever. But in biology, we're very practical people. You do something three times and do a T-test. And I think my prediction is we can actually gauge the success of these LLMs or whatever in biology by how much we respect theory in this field.The A.I. ScientistEric Topol (34:05):Yeah. Well, that's a really interesting perspective, an important perspective because the proliferation of models, which we're going to get into not just doing the things that you described, but also being able to be “pseudo” scientists, the so-called AI scientist. Maybe you could comment about that concept because that's been the idea that everything from the question that could be asked to the hypothesis and the experiment design and the analysis of data and then the feedback. So what is the role of the scientists, that seems to have been overplayed? And maybe you can put that in context.Patrick Hsu (34:48):So yeah, right now there's a lot of excitement that we can use AI agents not just to do software enterprise workflows, but to be a research assistant. And then over time, itself an autonomous research scientist that can read the literature, come up with an idea, maybe run a bunch of robots in the lab or do a bunch of computational analyses and then potentially even analyze data, conclude what is going on and actually write an entire paper. Now, I think the vision of this is compelling in the long term. I think the question is really about timescale. If you break down the scientific method into its constituent parts, like hypothesis generation, doing an experiment, analyzing experiment and iterating, we're clearly going to use AI of some kind at every single step of this cycle. I think different steps will require different levels of maturity. The way that I would liken this is just wet lab automation, folks have dreamed about having pipetting robots that just do their western blots and do their cell culture for them for generations.(36:01):But of course, today they don't actually really feel fundamentally different from the same ones that we had in the 90s, let's say. Right? And so, obviously they're getting better, but it seems to me one of the trends I'm very bullish about is the explosion of humanoid robots and robot foundation models that have a world model and a sense of physics and proportionate space loaded onto them. Within five years, we're going to have home robots that can fold your clothes, that can organize your kitchen and do all of this while you're sleeping, so you wake up to a clean home every day.Eric Topol (36:40):It's not going to be just Roomba anymore. There's going to be a lot more, but it isn't just the hardware, it's also the agents playing in software, right?Patrick Hsu (36:50):It's the integrated loop of the hardware and the software where the ability to make the same machine generally intelligent will make it adaptable to a broad array of tasks. Now, what I'm excited about is those generally intelligent humanoid robots coming into the lab, where instead of creating a centrifuge or a new type of pipetter that's optimized for your Beckman or Hamilton device, instead you just have robot arms that you snap onto the edge of the bench and then they just work alongside you. And I do think that's coming, although it'll take a lot of hardware and software and computer vision engineering to make that possible.A Sense of HumorEric Topol (37:32):Yeah, and I think also going back to originating the question, there still is quite a debate about the creativity and the lack of any simulation of AGI, whatever that means anymore. And so, the human in the loop part of this is obviously I think it's still of critical nature. Now, the other thing I learned about you is you have a great sense of humor, which is really important by the way. And recently, which is great that you're active on X or Twitter because that's one way we get to see what you're thinking on a day-to-day basis. But I think you put out a poll which was really quite provocative , and it was about, here's what it said, “do more people in the world *truly* understand transformers or health insurance?” And interestingly, you got 49% for transformers at 51% for health insurance. Can you tell us what you're thinking when you put that poll together? Because obviously a lot of people don't understand either of these.Patrick Hsu (38:44):I think the core question is, there are different ways of looking at the world, some of which are very bottom up and some of which are very top down. And one of the very surprising things about transformers is they're taking something that is in principle, an incredibly simple task, which is if you have a string of text, what is the next letter? And somehow at massive, massive scale, you can unlock something that looks an awful lot like reasoning, and you've got these emergent behaviors. Now the bottoms up theory of just the linear algebra that's going on in these models couldn't possibly really help us predict that we have these emerging capabilities. And I think similarly in healthcare, there's a literal set of parts that are operating in some complex way that at massive scale becomes this incredibly confusing and dynamic system for how we can actually incentivize how we make medicines, how we actually take care of people, and how we actually pay for any of this from an economic point of view. And so, I think it was, in some sense if transformers can actually be an explainable by just linear algebra equations, maybe there will be a way to decompose the seemingly incredibly confusing world of healthcare in order to actually build a better way forward.Computing Power and the GPU Arms RaceEric Topol (40:12):Yeah. Well that's great. Now the other thing I wanted to ask you about, we open source and the arms race of GPUs and this whole kind of idea is you touched on the need for coalescing a lot of these tools to exploit the synergy. But we have an issue because many academic labs like here at Scripps Research and so many others, including as I learned even at Stanford, have limited access to GPUs. So computing power of large language models is a problem. And then the models that exist today that can be adopted like Llama or others, and they're somewhat limited. And then we also have a movement towards trying to make things more open source, like for example, recently OpenCRISPR with Profluent Bio that is basically trying to use AI for CRISPR guides. And so, how do you deal with this arms race, computing power, open source, proprietary models that are not easily accessible without a lot of resources?Patrick Hsu (41:30):So the first thing I would say is, we are in the academic science sphere really unprepared for the level of resources that are required for doing this type of cutting edge computational work. There are top Stanford computer science professors or computational researchers who have a single GPU in their office, and that's actually what their whole lab runs off of.(41:58):The UC Berkeley campus, the grid runs on something like 12 megawatts of power and how are they going to build an on-premises GPU clusters, like a central question that can scale across the entire needs? And these are two of the top computer science universities in the world. And so, I think one of our kind of core beliefs at Arc is, as science both experimentally and computationally has gotten incredibly complex, not just in terms of conceptually, but also just the actual infrastructure and machines and know-how that you need to do things. We actually need to essentially support this. So we have a private GPU cloud that we use to train our models, and we have access to significantly large clusters for large burst kind of train outs as necessary. And I think infrastructurally for running genomics experiments or doing scalable brain organoid screens, right, we're also building out the infrastructure to support that experimentally.Eric Topol (43:01):Yeah, no, I think this is one of the advantages of the new model like the Arc Institute because not many centers have that type of plasticity with access to computing power when needed. So that's where a brilliant mind you and the Arc Institute together makes for a formidable recipe for future advances and of course building on the ones you've already accomplished.The Primacy of Human TalentPatrick Hsu (43:35):I would just say, my main skill, if I have one, is to recruit really, really smart people. And so, everything that you're seeing and hearing about is the work of unbelievable colleagues who are curious, passionate, and incredible scientists.Eric Topol (43:53):But it also takes the person who can judge those who are in that category set as a role model. And you're certainly doing that. I guess just in closing, I mean, it's just such a delight to get to meet you here and kind of get your thoughts on what is the hottest thing in life science without question, which brings together the fields of AI and what's going on, not just obviously in genome editing, but this digital biology era that we're still in the early phases of, I mean, I think you could say that it's just going to continue to accelerate the exponential curve. We're still kind of on the bottom of that, I would imagine where we're headed. Any other things that you want to bring up that I haven't touched on that will round out this conversation?Patrick Hsu (44:50):I mean, I think it's very early days here at Arc.Patrick Hsu (44:53):When we founded Arc, we asked ourselves, how do we measure success? We don't have customers or revenue in the way that a typical startup does. And we felt sort of three things. The first was research institutes live and die by their talent. Can we actually hire incredible people when we make offers to people we want to come, do they come? The second was, when those folks do come to Arc, do they feel like they're able to work on important research programs that they couldn't do sort of at their prior university or company? And then longer term, the third thing was, and there's just no shortcut around this, you need to do important work. And I think we've been really excited that there are early signs that we're able to do all three of these things, and we're still, again, just following the same scaling laws that we're seeing in natural language and vision, but for the domain of biology. And so, we're excited about what's ahead and think if there are folks who are interested in learning more about Arc, just shoot me an email or DM.Eric Topol (46:07):Yeah, well I would just say, congratulations on what you've already achieved. I know you're going to keep rocking it because you already have in a short time. And for anybody who doesn't know about Arc Institute and your work and your team, I hope this is going to be putting them on notice actually what can be accomplished outside of the usual NIH funded model, which is kind of a risk-free zone where you basically have to have your results nailed down before you send in your proposal frequently, and it doesn't do great things for young people. Really, I think you actually qualify in that demographic where it's hard for them to break in for getting NIH grants and also for this type of work that you're doing. So we'll look for the next bridge beyond bridge RNAs of your just fantastic efforts. So Patrick, thanks so much for joining us today, and we'll be checking back with you and following all the great work that you'll be doing in the times ahead.Patrick Hsu (47:14):Thanks so much, Eric. It was such a pleasure to be here today. Appreciate the opportunity.*******************Thanks for listening, reading or watching!The Ground Truths newsletters and podcasts are all free, open-access, without ads.Please share this post/podcast with your friends and network if you found it informative!Voluntary paid subscriptions all go to support Scripps Research. Many thanks for that—they greatly help fund our summer internship programs.Thanks to my producer Jessica Nguyen and Sinjun Balabanoff for audio and video support at Scripps Research.Note: you can select preferences to receive emails about newsletters, podcasts, or all I don't want to bother you with an email for content that you're not interested in. Get full access to Ground Truths at erictopol.substack.com/subscribe

Dr. Kemaladewi has extensive training in human genetics and development of genetic therapy, with a focus on neuromuscular disorders. She is interested in understanding the molecular mechanisms underlying layers of pathophysiology involved in muscular dystrophies, including muscle atrophy, -regeneration, -fibrosis, and nerve damages. In parallel, the exposure to technology-driven field of human genetics has provided a strong basis on her translational research arm. She has a robust portfolio on the development and evaluation of therapeutic genetics, such as antisense oligonucleotides and CRISPR/Cas to correct mutations and modulate disease modifier genes in mouse models.

Den ärftliga nervsjukdomen Skelleftesjukan är nu en av de första sjukdomarna där man provar behandling med genkniven CRISPR Cas-9. Och fler står på tur. Lyssna på alla avsnitt i Sveriges Radio Play. Förhoppningarna är stora på att gentekniken ska kunna göra oss friskare, men farhågor har också följt genteknikens utveckling.Repris från 22 feb 2024.I Vetenskapspodden hörs: Annika Östman, medicinreporter, Tomas Lindblad frilansande vetenskapsjournalist.Poddledare: Camilla WidebeckProducent: Peter Normark

Today, we're joined by Eric Nguyen, PhD student at Stanford University. In our conversation, we explore his research on long context foundation models and their application to biology particularly Hyena, and its evolution into Hyena DNA and Evo models. We discuss Hyena, a convolutional-based language model developed to tackle the challenges posed by long context lengths in language modeling. We dig into the limitations of transformers in dealing with longer sequences, the motivation for using convolutional models over transformers, its model training and architecture, the role of FFT in computational optimizations, and model explainability in long-sequence convolutions. We also talked about Hyena DNA, a genomic foundation model pre-trained on 1 million tokens, designed to capture long-range dependencies in DNA sequences. Finally, Eric introduces Evo, a 7 billion parameter hybrid model integrating attention layers with Hyena DNA's convolutional framework. We cover generating and designing DNA with language models, hallucinations in DNA models, evaluation benchmarks, the trade-offs between state-of-the-art models, zero-shot versus a few-shot performance, and the exciting potential in areas like CRISPR-Cas gene editing. The complete show notes for this episode can be found at https://twimlai.com/go/690.

Scott Rettberg is back with another episode of the podcast ‘Off Center'. This time he is joined by Søren Pold, Associate professor of Digital Design at Aarhus University. They discuss digital literature, platformazation, and the COVID-19 pandemic. This episode also includes a new AI update with David Jhave Johnston. Together with Scott, he will bring you up to date about recent AI medical advances. The AI update starts at 18:13. References   Abramson, Josh, Adler, Jonas, Dunger, Jack, et al. 2024. Accurate structure prediction of biomolecular interactions with AlphaFold 3. Nature 630, 493–500. https://doi.org/10.1038/s41586-024-07487-w.   Ahmad, Irshad. 2022. CRISPR/Cas9—A Promising Therapeutic Tool to Cure Blindness: Current Scenario and Future Prospects. International Journal of Molecular Sciences, 23(19), 11482.  Elias, Pierre, Jain, Sneha, Poterucha, Timothy, et al. 2024. Artificial Intelligence for Cardiovascular Care-Part 1: Advances: JACC Review Topic of the Week. Journal of the American College of Cardiology.  Fuller, Matthew, Green, Colin, & Pope Simon. 1997. The Web Stalker. I/O/D.  Nacher, Anna, Rettberg, Scott, & Pold, Søren. 2021. COVID E-LIT: Digital Art from the Pandemic. Electronic Book Review. DOI: 10.7273/kehh-8c3.  Nacher, Anna, Rettberg, Scott, Pold, Søren Bro & Steele, Ashleigh. 2022. COVID E-LIT: Digital Art During the Pandemic. Documentary. 44 min., 12 sec.    Rettberg, Jill Walker. 2010. Feral hypertext: when hypertext literature escapes control. International Handbook of Internet Research, 477-492.  Richard, Guillaume, de Almeida, Bernardo P., Dalla-Torre, Hugo, et al. 2024. ChatNT: A Multimodal Conversational Agent for DNA, RNA and Protein Tasks. bioRxiv, 2024-04.  Ruffolo, Jeffrey A., Nayfach, Stephen, Gallagher, Joseph, et al. 2024. Design of highly functional genome editors by modeling the universe of CRISPR-Cas sequences. bioRxiv, 2024-04. https://doi.org/10.1101/2024.04.22.590591.  Yang, Lin, Xu, Shawn, Sellergren, Andrew, et al. 2024. Advancing Multimodal Medical Capabilities of Gemini. arXiv preprint arXiv:2405.03162.  Zhao, Yujahio, Ding, Ye, Lau Vick, et al. 2024. Whole-body magnetic resonance imaging at 0.05 Tesla. Science. DOI:10.1126/science.adm7168.  

Erfahre wie mit der Genschere CRISPR/Cas-9 die Lebenszeit vervierfacht wird, warum es längst kein Traum mehr ist Genveränderte Babies zu haben, warum es die größte Gefahr seit der Atombombe ist, was ein PlanetKillerVirus ist und warum noch keines hergestellt wurde, welche riesen Chancen es uns bietet und noch vieles mehr! Niko ist Doktor und Professor an der Uni in Jena und leitet den ersten in Deutschland eingerichteten Lehrstuhl für angewandte Ethik. Finde ihn hier: www.ethik.uni-jena.de PS: Dieser Podcast ist ein Herzensprojekt und du kannst ihn gerne unterstützen auf Patreon (Danke!!!): https://patreon.com/inspirierendanders

De landbouw is in Nederland de sector die het meeste exporteert. Kan Nederland zo'n grote rol in de voedselvoorziening houden als er duurzamer geproduceerd moet worden? En hoe kunnen innovaties als Crispr-Cas en kweekvlees ons dieet gaan veranderen? Te gast is Sjoukje Heimovaara, bestuursvoorzitter van Wageningen University & Research. Gasten in BNR's Big Five van Innovatie onder druk: - Roland van der Vorst, hoofd innovatie Rabobank en ceo van Rabo Carbon Bank - Jan Rotmans, hoogleraar Transitiekunde aan de Erasmus Universiteit - Inge van Dijk, directeur Betalen, Cash & Marktinfrastructuur bij DNB - Cynthia Liem, universitair hoofddocent van de afdeling Intelligente Systemen aan de TU Delft - Sjoukje Heimovaara, bestuursvoorzitter van Wageningen University & ResearchSee omnystudio.com/listener for privacy information.

Den ärftliga nervsjukdomen Skelleftesjukan är nu en av de första sjukdomarna där man provar behandling med genkniven CRISPR Cas-9. Och fler står på tur. Lyssna på alla avsnitt i Sveriges Radio Play. Förhoppningarna är stora på att gentekniken ska kunna göra oss friskare, men farhågor har också följt genteknikens utveckling.I Vetenskapspodden hörs: Annika Östman, medicinreporter, Tomas Lindblad frilansande vetenskapsjournalist.Poddledare: Camilla WidebeckProducent: Peter Normark

Episode 13: Creative AI with David Jhave Johnston In this first episode of season two, Scott is joined by David Jhave Johnston, digital poet, videographer, and motion graphics artist. Together they talk about digital poetry, cyborg authorship, and the use of AI for content creation.   References Johnston, D. J. 2016. Aesthetic Animism: Digital Poetry's Ontological Implications. The MIT Press. https://mitpress.mit.edu/9780262034517/aesthetic-animism/. Johnston, D. J. 2018. ReRites. Anteism Books. https://glia.ca/rerites/. Open AI.  n.d. “ChatGPT,” https://chat.openai.com/. Google Deepmind. n.d. “Gemini.” Gemini, https://www.gemini.com/. 23andMe Holding Co. n.d. “23andMe,” https://www.23andme.com/en-int/. Johnston, D. J. 2023. “Identity Upgrade Series”, https://glia.ca/. Karp, A. C. July 25, 2023. “Our Oppenheimer Moment: The Creation of A.I. Weapons.” The New York Times, https://www.nytimes.com/2023/07/25/opinion/karp-palantir-artificial-intelligence.html. Luckey, P. 2017. “Command and Control.” Anduril, https://www.anduril.com/command-and-control/. Suchman, L. 2023. “The Uncontroversial ‘thingness' of AI.” Big Data & Society 10, no. 2 (July). https://doi.org/10.1177/20539517231206794. Reardon. S. 2023. “FDA Approves First CRISPR Gene Editing Treatment for Sickle Cell Disease”. Last modified December 8, 2023. Scientific American. https://www.scientificamerican.com/article/fda-approves-first-crispr-gene-editing-treatment-for-sickle-cell-disease/. Altae-Tran, H., Kannan, S., et al. 2023. Uncovering the functional diversity of rare CRISPR-Cas systems with deep terascale clustering. Science. DOI: 10.1126/science.adi1910. Lovelock, J. 2019. Novacene: The Coming Age of Hyperintelligence. Penguin Books Limited. Kurzweil, R. 2005. The Singularity Is Near: When Humans Transcend Biology. Viking. Kurzweil, R. 2000. “Ray Kurzweil's Cybernetic Poet: HOW IT WORKS”. [Poetry machine]. https://www.kurzweilcyberart.com/poetry/rkcp_how_it_works.php.

Wärme und Feuchtigkeit schaffen ideale Bedingungen für Krankheiten, die durch Pilze verursacht werden. Im Zuge des Klimawandels fürchten Fachleute eine Zunahme des Pilzbefalls bei unseren Nutzpflanzen und Ernteausfälle bis zu 30 Prozent. Die grüne Gentechnik wie etwa CRISPR/Cas könnte helfen, Pflanzen widerstandsfähiger zu machen.

735 miljoen mensen op de wereld lijden honger, zo stelt de VN. De inmiddels 89-jarige Simon Groot stelde zichzelf als doel om boeren in de armste delen van de wereld te helpen door betere zaden te leveren. Na de oprichting van het bedrijf East-West Seed vloeide de onderneming door naar zijn kinderen. In ‘De top van Nederland' een uitgebreid gesprek met Rutger Groot, zoon van Simon en lid van de raad van commissarissen van East-West Seed Presentator Thomas van Zijl vraagt hem of...  - het bedrijf zich bewust focust op landen in de tropen;   - geld verdienen of boeren helpen voorop staat;  - honger in 2030 uit de wereld is;  - de EU gentechnologie CRISPR-Cas toe moet staan;  - hij niet zelf directeur van East-West Seed had willen worden.  Over East-West Seed  East-West Seed is een Nederlands bedrijf groentezaden veredelt. Het bedrijf is actief in 75 landen en richt zich vooral op tropische groente.   Over Thomas van Zijl  Thomas van Zijl is financieel journalist en presentator bij BNR. Hij presenteert dagelijks ‘BNR Zakendoen', het Nederlandse radioprogramma voor economisch nieuws en zakelijk inzicht, waar 'De top van Nederland' onderdeel van is. Ook is hij een van de makers van de podcast ‘Onder curatoren'.  Abonneer je op de podcast  Ga naar ‘De top van Nederland' en abonneer je op de podcast, ook te beluisteren via Apple Podcast en Spotify.   See omnystudio.com/listener for privacy information.

C'est sans doute la découverte la plus importante depuis celle de l'ADN en 1953. La technique d'édition génétique CRISPR-Cas va littéralement révolutionner l'agriculture, la santé humaine, bref, notre vie, et on en voit enfin, en cette année 2023, les premières applications concrètes.

Weitere Themen: Windenergie in Bayern - Wo sollte man ausbauen?Impfung gegen RSV - Gibt es ein Risiko für Frühgeburten?Nachplappern und Nachmachen - Wie Babys Imitieren lernen

Mit der Genschere CRISPR/Cas kann man gezielt Teile aus dem Erbgut herausschneiden und sie ersetzen. Diese Methode ist noch relativ neu. Jetzt wurde in Großbritannien zum ersten Mal eine CRISPR/Cas-Gentherapie für den Menschen zugelassen: für Patienten mit Sichelzellkrankheit oder Thalassämie.

Böddeker, Michaelwww.deutschlandfunk.de, Forschung aktuellDirekter Link zur Audiodatei

Nos ponemos al día sobre todo lo que ha ocurrido en el mundo de la ciencia y la tecnología esta semana, que es muchísimo. Jaime García Cantero y Nuño Domínguez comentan para empezar el fallecimiento, conocido esta misma mañana, del segundo trasplantado de corazón de cerdo modificado genéticamente. Ha llegado a vivir 6 semanas. La muerte de un enfermo siempre es un fracaso, pero en este caso el paciente estaba defenestrado, no tenía ninguna otra opción de vida y, teniendo él mismo formación científica, seguía con interés su propio tratamiento, analizando sus propias biopsias. Nuño recueda que, los primeros años, el mundo de los trasplantes era "un matadero", y ahora los pacientes trasplantados de corazón sobreviven una media de 10 años. Como comentará más adelante Miguel Ángel Moreno Mateos, organizador del próximo congreso en Sevilla sobre la edición genética con la técnica CRISPR-CAS, "la paciencia es la madre de la ciencia". Nuño nos explica en qué consiste esta técnica, para qué sirve, y los riesgos que tiene, según ha advertido esta semana la FDA al abrir la puerta al primer medicamento que usa CRISPR para curar una enfermedad genética. Ojalá la primera de muchas.Además, Jaime explica en qué consiste "el subconsciente del algoritmo", que tiende a dar más visibilidad a los contenidos sexualizados, a pesar de que la pornografía (y los pezones) estén expresamente prohibidos. Y en Inglaterra se celebra la primera conferencia internacional sobre seguridad e Inteligencia Artificial. Lo primero que hay que decir es que llegamos tarde, y lo segundo, la escasa ambición de la agenda. Jaime recuerda las tres "D" que marcan estos discursos: la Dominación china, el Darwinismo estadounidense y los Derechos en Europa, que muchas veces derivan en una cuarta "D", la de desorganización. Por último, comentamos, con nuestro corresponsal en París Vicenç Batalla, el informe publicado por dos ONGs francesas sobre la cantidad de dinero que bancos y empresas francesas invierten en "bombas de carbono", megaproyectos de extracción de combustibles fósiles. Es una cifra completamente incompatible con frenar el calentamiento global. Un nuevo ejercicio de cinismo. Mientras haya combustibles fósiles que explotar, parece que seguirán explotándose, así se acabe el mundo. Literalmente. 

Drei HIV-Infizierte werden in den USA mit der Genschere CRISPR/Cas behandelt. Ziel ist es, die Virus-DNA in ihren Immunzellen aufzuspüren und zu entfernen. So ließe sich eine Infektion nicht nur wie bisher kontrollieren, sondern beseitigen.Lange, Michaelwww.deutschlandfunk.de, Forschung aktuellDirekter Link zur Audiodatei

In this episode:00:47 An RNA-based viral system that mimics bacterial immune defencesTo protect themselves against viral infection, bacteria often use CRISPR-Cas systems to identify and destroy an invading virus's genetic material. But viruses aren't helpless and can deploy countermeasures, known as anti-CRISPRs, to neutralise host defences. This week, a team describe a new kind of anti-CRISPR system, based on RNA, which protects viruses by mimicking part of the CRISPR-Cas system. The researchers hope that this discovery could have future biotechnology applications, including making CRISPR-Cas genome editing more precise.Research article: Camara-Wilpert et al.09:05 Research HighlightsCarved inscriptions suggest a queen named Thyra was the most powerful person in Viking-age Denmark, and the discovery of a puffed-up exoplanet that has just 1.5% the density of Earth.Research Highlight: Runes on Viking stones speak to an ancient queen's powerResearch Highlight: ‘Super-puff' planet is one of the fluffiest worlds ever found11:38 Modelling the future of Greenland's ice sheet meltClimate-change induced melting of Greenland's vast ice sheet would contribute to 7m of sea level rise. But it has been difficult to calculate how the ice sheet will respond to future warming. This week, a team suggest that abrupt ice loss is likely if the global mean temperature is between 1.7 °C and 2.3 °C above pre-industrial levels. Keeping temperature rise below 1.5 °C could mitigate ice loss, if done within a few centuries, but even a short overshoot of the estimated threshold could lead to several metres of sea-level rise.Research article: Bochow et al.17:50 Briefing ChatA massive reproducibility exercise reveals over 200 ecologists get wildly-diverging results from the same data, and how melting simulated lunar-dust with lasers could help pave the Moon.Nature News: Reproducibility trial: 246 biologists get different results from same data setsNature News: How to build Moon roads using focused beams of sunlightSubscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.

Het is sneller, makkelijker en kent alleen maar winnaars: CRISPR-Cas. Door een nauwkeurige knip in het DNA van een plantenzaadje kunnen voedselgewassen worden aangepast aan de wensen van teler en consument. Althans... dat stellen voorstanders. Vandaag bieden tegenstanders in de Tweede Kamer een petitie aan die ruim 40.000 keer is ondertekent. Wat zijn de voor- en nadelen van genetisch gemodificeerd voesel? In deze podcast praat Stephan met Michel Haring, hoogleraar platenfysiologie aan de Unveristeit van Amsterdam. 

We talk to Dr Vijay Yadav about his planned next steps for interventional human trials and what doses he will try. Dr Yadav leads the Systems Biology of Aging Laboratory, which aims to identify novel functional connections between organs and to unravel factors that underlie human metabolism and its disorders. The lab's expertise is in the development of a variety of technologies including mouse genetic (CRISPR/Cas, homologous recombination in embryonic stem cells, iPS cells), genomic (Nucleic acid sequencing), and proteomic (MS/NMR/HPLC). The ultimate aim is to identify novel therapeutic targets for genetic and metabolic disorders to manage these diseases in humans.

We talk to Dr Vijay Yadav about the human results from the trial and how the dosage might translate into humans. Dr Yadav leads the Systems Biology of Aging Laboratory, which aims to identify novel functional connections between organs and to unravel factors that underlie human metabolism and its disorders. The lab's expertise is in the development of a variety of technologies including mouse genetic (CRISPR/Cas, homologous recombination in embryonic stem cells, iPS cells), genomic (Nucleic acid sequencing), and proteomic (MS/NMR/HPLC). The ultimate aim is to identify novel therapeutic targets for genetic and metabolic disorders to manage these diseases in humans.

We talk to Dr Vijay Yadav about some of the results in terms of lifespan and healthspan from the recent paper that he was the main author on. Dr Yadav leads the Systems Biology of Aging Laboratory, which aims to identify novel functional connections between organs and to unravel factors that underlie human metabolism and its disorders. The lab's expertise is in the development of a variety of technologies including mouse genetic (CRISPR/Cas, homologous recombination in embryonic stem cells, iPS cells), genomic (Nucleic acid sequencing), and proteomic (MS/NMR/HPLC). The ultimate aim is to identify novel therapeutic targets for genetic and metabolic disorders to manage these diseases in humans.

We talk to Dr Vijay Yadav about taurine, why he started studying it, some of the history and how it varies with age. Dr Yadav leads the Systems Biology of Aging Laboratory, which aims to identify novel functional connections between organs and to unravel factors that underlie human metabolism and its disorders. The lab's expertise is in the development of a variety of technologies including mouse genetic (CRISPR/Cas, homologous recombination in embryonic stem cells, iPS cells), genomic (Nucleic acid sequencing), and proteomic (MS/NMR/HPLC). The ultimate aim is to identify novel therapeutic targets for genetic and metabolic disorders to manage these diseases in humans.

El uso de la tecnología CRISPR/CAS podría detener en seco la propagación de una de las enfermedades más letales del mundo, sin embargo su uso ha generado una fuerte discusión sobre la ética de su aplicación... ¿porqué? Gracias por sus comentarios, interacciones, apoyo económico y suscripción. Escuche y descargue gratuitamente en MP3 2023/07/06 CRISPR Contra la Malaria. Gracias por su apoyo a El Explicador en: Patreon, https://www.patreon.com/elexplicador_enriqueganem PayPal, elexplicadorpatrocinio@gmail.com SoundCloud, https://soundcloud.com/el-explicador Spotify, https://open.spotify.com/show/01PwWfs1wV9JrXWGQ2MrbY iTunes, https://podcasts.apple.com/mx/podcast/el-explicador-sitio-oficial/id1562019070 Amazon Music, https://music.amazon.com/podcasts/f2656899-46c8-4d0b-85ef-390aaf20f366/el-explicador-sitio-oficial YouTube, https://youtube.com/c/ElExplicadorSitioOficial Twitter @enrique_ganem Lo invitamos a suscribirse a estas redes para recibir avisos de nuestras publicaciones y visitar nuestra página http://www.elexplicador.net. En el título de nuestros trabajos aparece la fecha año/mes/día de grabación, lo que facilita su consulta cronológica, ya sabe usted que el conocimiento cambia a lo largo del tiempo. Siempre leemos sus comentarios, no tenemos tiempo para reponder a cada uno personalmente pero todos son leídos y tomados en cuenta. Este es un espacio de divulgación científica en el que nos interesa informar de forma clara y amena, que le invite a Ud. a investigar sobre los temas tratados y a que Ud. forme su propia opinión. Serán borrados todos los comentarios que promuevan la desinformación, charlatanería, odio, bullying, violencia verbal o incluyan enlaces a páginas que no sean de revistas científicas arbitradas, que sean ofensivos hacia cualquier persona o promuevan alguna tendencia política o religiosa ya sea en el comentario o en la fotografía de perfil. Aclaramos que no somos apolíticos, nos reservamos el derecho de no expresar nuestra opinión política, ya que éste es un canal cuya finalidad es la divulgación científica. ¡Gracias por su preferencia!

Die EU möchte die Regeln für den Einsatz von Gentechnik in der Landwirtschaft lockern, denn seit dem Durchbruch der CRISPR/Cas-Methode hat sich viel getan: Wie verändert man das Erbgut von Pflanzen im Labor, was sind die Risiken und wie wichtig werden gen-veränderte Nutzpflanzen, wenn sich die Erde erwärmt? Jochen Steiner im Gespräch mit Holger Puchta, Pflanzengenetiker am Karlsruher Institut für Technologie

Yhdysvalloissa ja muissakin maissa on käynnissä useita kliinisiä kokeita, joissa tutkitaan CRISPR-Cas 9 -geenimuokkaustyökalun toimivuutta sairauksien hoidossa. Kliinisiä kokeita on menossa muun muassa sirppisolutautiin, syöpiin, perinnölliseen sokeuteen, diabetekseen, hyperkolesterolemiaan, HIV-infektioon ja jopa yleiseen vaivaan, virtsatieinfektioon. Sirppisolutaudin ja leukemian hoidossa on saatu jo positiivisia tuloksia. CRISPR-tekniikan avulla muunnos voidaan tehdä tarkasti halutussa kohdassa geeniä. Menetelmän kehittäjät ranskalainen Emmanuelle Charpentier ja yhdysvaltalainen Jennifer Doudna palkittiin kemian Nobelilla vuonna 2020. CRISPR-menetelmä herättää myös epäilyksiä ja pelkoja, koska se tarjoaa keinot muokata perimää lähes mielin määrin. Vuonna 2018 Kiinassa syntyneet CRISPR-vauvat, joiden perimään kiinalainen tutkija oli tutkijayhteisön tietämättä tehnyt geenimuunnoksen, nostivat esiin muuntelua koskevat tärkeät eettiset ja yhteiskunnalliset kysymykset. Haastateltavana on perinnöllisyyslääkäri, dosentti Kirmo Wartiovaara Helsingin yliopistosta. Tutkimusjohtaja Juha Klefström Helsingin yliopistosta muistelee menetelmän alkuhistoriaa haastattelussa, joka on vuodelta 2019. Toimittajana on Sisko Loikkanen.

Show Notes: Transhumanism = (“Prerequisite to the Mark of The Beast?”) Human Augmentation 2023, Crispr Cas-9, Vaccine Nanotechnology, Gender Dysphoria, Occultism, Atlantis, The Great Reset, The Fourth Industrial Revolution, The New World Order, Biblical Prognostications. All program donations to be sent to $aigner2019(cashapp) or PayPal: https://www.paypal.me/Aigner2019

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 6, entitled, “Knockout of AMD-associated gene POLDIP2 reduces mitochondrial superoxide in human retinal pigment epithelial cells.” Genetic and epidemiologic studies have significantly advanced our understanding of the genetic factors contributing to age-related macular degeneration (AMD). In particular, recent expression quantitative trait loci (eQTL) studies have highlighted POLDIP2 as a significant gene that confers risk of developing AMD. However, the role of POLDIP2 in retinal cells such as retinal pigment epithelium (RPE) and how it contributes to AMD pathology are unknown. In this new study, researchers Tu Nguyen, Daniel Urrutia-Cabrera, Luozixian Wang, Jarmon G. Lees, Jiang-Hui Wang, Sandy S.C. Hung, Alex W. Hewitt, Thomas L. Edwards, Sam McLenachan, Fred K. Chen, Shiang Y. Lim, Chi D. Luu, Robyn Guymer, and Raymond C.B. Wong from Royal Victorian Eye and Ear Hospital, University of Melbourne, St Vincent's Institute of Medical Research, University of Tasmania, and The University of Western Australia report the generation of a stable human RPE cell line ARPE-19 with POLDIP2 knockout using CRISPR/Cas, providing an in vitro model to investigate the functions of POLDIP2. “We conducted functional studies on the POLDIP2 knockout cell line and showed that it retained normal levels of cell proliferation, cell viability, phagocytosis and autophagy. Also, we performed RNA sequencing to profile the transcriptome of POLDIP2 knockout cells.” Their results highlighted significant changes in genes involved in immune response, complement activation, oxidative damage and vascular development. They showed that loss of POLDIP2 caused a reduction in mitochondrial superoxide levels, which is consistent with the upregulation of the mitochondrial superoxide dismutase SOD2. In conclusion, this study demonstrates a novel link between POLDIP2 and SOD2 in ARPE-19, which supports a potential role of POLDIP2 in regulating oxidative stress in AMD pathology. “In summary, we have generated a POLDIP2 knockout ARPE-19 cell line using CRISPR/Cas9 and studied the biological functions of POLDIP2. To our knowledge, this is the first functional study of POLDIP2 in retinal cells to understand its potential role in AMD.” DOI: https://doi.org/10.18632/aging.204522 Corresponding Author: Raymond C.B. Wong - wongcb@unimelb.edu.au Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.204522 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, age-related macular degeneration, retina, CRISPR/Cas, mitochondria superoxide, POLDIP2 About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com​​ and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ Twitter - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

Pierwszy genetycznie zmodyfikowany produkt, pomidor Flavr Savr trafił do konsumentów prawie 30 lat temu. I nie od razu wzbudził panikę. Protesty i kampanie społeczne przeciwko zastosowaniu inżynierii genetycznej w produkcji żywności miały miejsce później, na przełomie wieków. Od tego czasu przeprowadzono setki badań i stworzono wiele różnych genetycznie modyfikowanych odmian kukurydzy, bawełny, ziemniaków czy chociażby różowego ananasa. Jednak w większości krajów – w tym w Unii Europejskiej, gdzie obowiązują jedne z najbardziej restrykcyjnych przepisów w tym zakresie – żaden z tych produktów nie trafił na rynek i nie zyskał aprobaty, ani politycznej, ani społecznej. Światowy Program Żywnościowy donosi, że w 2022 roku głodowało 350 milionów ludzi, najwięcej we współczesnej historii świata. W rozwiązaniu kryzysu żywnościowego z pewnością nie pomagają też dotkliwe skutki zmian klimatu. W tej sytuacji konieczne wydaje się poszukiwanie sposobów na maksymalizowanie zbiorów i zwiększanie efektywności upraw. A to jest jednym z celów modyfikacji genetycznych. Czy jesteśmy dziś gotowi na rzetelną dyskusję na temat GMO? Posłuchajcie mojej rozmowy z prof. Pawłem Golikiem, szefem Instytutu Genetyki i Biotechnologii Wydziału Biologii na Uniwersytecie Warszawskim. Zapraszam! Barbara Sowa A tutaj znajdziecie wspomniany w podcaście tekst o metodzie CRISPR/CAS, zatytułowany “Każdy chce być stworzycielem”: https://magazynpismo.pl/kazdy-chce-byc-stworzycielem-crispr-lamza/ - Dla słuchaczy podcastu „Jak naprawić przyszłość?” przygotowaliśmy kod zniżkowy na dostęp online do „Pisma". Wejdź na http://magazynpismo.pl/prenumerata i wpisz na dole strony kod: JNP, skorzystaj z oferty – czytaj i słuchaj przez pierwsze 5 miesięcy za połowę ceny (5,49 zł). Subskrypcja odnawia się co miesiąc, możesz zrezygnować w dowolnym momencie.

Chinese biophysicist He Jiankui caused international outrage when in 2018 when he used the gene-editing tool known as CRISPR Cas-9 to edit the genomes of two human embryos. That experiment, described by the Chinese Academy of Science and Technology described as ‘abominable', resulted in the birth of twin girls. The experiment also landed Dr He in prison for three years. Now, out of prison and working for a company in Beijing that proclaims to offer “affordable gene therapy” – He Jiankui has been speaking in public. At an open bioethics event at the University of Kent last weekend, organisers invited the scientist to present his research and to face questions about his past experiments and his future plans. We spoke to event organiser Dr Joy Zhang about the reaction to event and to Professor Robin Lovell-Badge at the Crick Institute about the implications of CRISPR-CAS9 technology. A Hippo butchery site reveals that distant human ancestors have been using stone tools far longer than researchers previously thought. This archaeological site in Kenya revealed that ancient hominins Paranthropus have probably been using stone tools to prepare food and weapons since 2.9 million years ago. Professor Tom Plummer at Queens College, City University of New York take us through the discovery and what it reveals about hominin evolution. A study released this week reveals just how much of a burden sons are on killer whale mothers. Michael Wiess, research director at the centre for whale research, fills us in on their findings which are a product of nearly 40 years studying the southern resident Orca population. This long-term Whale census project began in the 70s, championed by researcher Ken Balcomb, who was passionate about understanding and protecting killer whales and who sadly passed away late last year. We hear from Ken and his team out on the water studying the southern residents, more of which can be found in BBC Radio 4 documentary The Whale Menopause. Presenter: Victoria Gill Producer: Emily Bird BBC Inside Science is made in collaboration with the Open University

Bei der Fischschuppenkrankheit bildet die Hornhaut Krusten und verfärbt sich. Die seltene Erkrankung ist nur wenig erforscht. Eine Crispr-Gentherapie, bei der defekte Gene verändert werden, könnte Betroffenen vielleicht helfen. Wildermuth, Volkartwww.deutschlandfunk.de, Forschung aktuellDirekter Link zur Audiodatei

In this episode, Hayden and Sanjana discuss recent advancements in CRISPR-Cas technology that allows for the specific enrichment or depletion of a single bacterial strain in a complex microbial community.

CRISPR-Cas is een methode waarmee DNA veranderd kan worden, met ongekende precisie. De mogelijkheden lijken enorm: van het bestrijden in de toekomst van allerlei ziektes tot het creëren van varkens zo klein als een chihuahua. De landbouw wil ook graag gebruik maken van de CRISPR-Cas-techniek. Bijvoorbeeld voor het veredelen van planten en zaden. In juni komt de Europese Commissie met een voorstel of ze de regels voor deze techniek zullen versoepelen. 

This episode: A bacteriophage that overcomes the bacterial CRISPR/Cas immune system by interrupting the CRISPR DNA with its own genome! Download Episode (6.8 MB, 10 minutes) Show notes: Microbe of the episode: Wenzhou mammarenavirus Takeaways Bacteria have many ways to resist being exploited by bacteriophage viruses, including the adaptable CRISPR/Cas system that uses a piece of viral nucleic acid sequence to target and destroy incoming phages. But phages also have many ways to evade and disrupt bacterial defenses. In this study, a phage is discovered that inserts its own genome into the CRISPR/Cas sequence in the bacterial genome, disrupting the bacterial defenses. To escape the defenses while it is doing this insertion, it carries genes for previously-unknown anti-CRISPR proteins. But inserting and removing a viral sequence from the bacterial genome is not always a clean procedure.   Journal Paper: Varble A, Campisi E, Euler CW, Maguin P, Kozlova A, Fyodorova J, Rostøl JT, Fischetti VA, Marraffini LA. 2021. Prophage integration into CRISPR loci enables evasion of antiviral immunity in Streptococcus pyogenes. 12. Nat Microbiol 6:1516–1525. Other interesting stories: Great article on the history of phage therapy Email questions or comments to bacteriofiles at gmail dot com. Thanks for listening! Subscribe: Apple Podcasts, Google Podcasts, Android, or RSS. Support the show at Patreon, or check out the show at Twitter or Facebook.

Reuzentomaten, extra zoete aardbeien, droogteresistente bananenplanten,... Het kan in theorie allemaal dankzij CRISPR-Cas, een techniek waarmee wetenschappers het DNA van planten en dieren kunnen aanpassen. Plantgenetici zoals Ramon de Koning (VUB) zijn er ook in praktijk mee bezig! We bezochten hem in de serres op het dak van de VUB waar hij kidneyboontjes kweekt... waar je geen windjes van moet laten!

This week's episode discusses a concept unveiled for the world's first artificial womb facility, aka a baby factory where you can create a designer baby leading to a discussion of all of the horrific dystopian realities this could create. We also discuss the recent scientific win of creating net-positive nuclear fusion and what that could lead to. Lastly, we discuss the recently proposed ban on Tiktok by congress.   Subscribe and leave a 5-star review! ----more---- Donate to support the show by going to https://givesendgo.com/redpillrevolution   Our website https://redpillrevolution.co/    Protect your family and support the Red Pill Revolution Podcast with Affordable Life Insurance. This is attached to my license and not a third-party ad!   Go to https://agents.ethoslife.com/invite/3504a now!   Currently available in AZ, MI, MO, LA, NC, OH, IN, TN, WV. Email austin@redpillrevolution.co if you would like to sign up in a different state   ----more---- Full Transcription    Welcome to the Revolution. Hello and welcome to Red Pill Revolution. My name is Austin Adams, and thank you so much for listening. Today, we are going to be touching on some wild scientific discoveries today and a few things that aren't scientific discoveries, , so let's talk about it. The very first thing is that the United States, uh, some scientific institution came out and talked about their ability to create potentially clean energy in an unlimited fashion. It was basically a, a scientific experiment that they'd been working on for quite some time where they were running 192 lasers. To try and see if they could cause nuclear fission fusion, nuclear fusion, , not fission, nuclear fusion. And that could mean for us unlimited clean energy, which would be nice according to what the cost of gas is. So that would be cool, although it's a much better than it's been. I would say it's about almost half of what I was paying at one point over the last few years. Anyways, after that, we are going to touch on Congress introducing a bill to ban TikTok over spying fears. Oh my gosh. It's almost as if somebody recommended that, I don't know, what was it, three years ago now, maybe four years ago. And now it's just a legitimate conversation all of a sudden because it didn't come from Donald Trump's mouth. And then, We are also going to be talking about Joe Biden getting a little upset over somebody bringing up his quote unquote fucking age , according to Joe Biden. He was pretty mad about that. And then lastly, what we are going to talk, talk about is the craziest thing, which is a company that unveil unveiled the world's first artificial womb. And if your face looks like mine right now, um, and it should, you, you're probably just as concerned as you should be. Um, it's pretty crazy and it's, uh, really, actually, really concerning. So we'll talk about that too, all of that and more. But the first thing I need you to do is go ahead and hit that subscribe button. Button. Hit the like button if there's a like button around, depending on what you're watching this on. And leave a five star review mean the world to me. It takes five seconds of your day. There's probably not too many things throughout your day right now that you could get some very beautiful, very wonderful karmic response from. And that is just by cooking a button on your phone. If you're driving, I forgive you. But when you stop, subscribe and leave a five star review. All right? Takes two seconds outta your day. It would really, really mean a lot if you hang out with me here consistently. You listen to this podcast, I appreciate you beyond words. Uh, but also I would appreciate if you leave a five star review, head over to Red Pill Revolution. Um, dot co.com is for losers red pill revolution.co. And sign up for the sub. All right, the sub's going to include all of the links, all of the videos, all of the topic videos, all of the episode, video, and audio directly to your email every single week, along with a little article that I write, depending on the week, um, about, uh, certain topics that we discussed as well. That's free, doesn't cost you anything. At the very bottom of that, you can sign up to be a paid subscriber, which just means that you actually, uh, really appreciate my content. And, uh, I think it's like $7 or whatever you can choose to, to pay as much as you want, I believe as well. Um, but I would appreciate it. All right, uh, no ads here. Um, that's all I got for you. So thank you so much for being a part of this, and let's jump into. Welcome to Red Pill Revolution. My name is Austin Adams. Red Pill Revolution started out with me, realizing everything that I knew, everything that I believed, everything I interpreted about my life is through the lens of the information I was spoonfed as a child. Religion, politics, history, conspiracies, Hollywood medicine, money, food, all of it. Everything we know was tactfully written to influence your decisions and your view on reality by those in power. Now I'm on a mission, a mission to retrain and reeducate myself to find the true reality of what is behind that curtain. And I'm taking your ass with me. Welcome to the Revolution. All right. The very first thing that we are going to talk about today is going to be a fusion energy breakthrough. Which could lead to unlimited clean energy, which they're saying may just be 10 years away, which would be, again, pretty nice for everybody's bank account, although I'm sure they'll find a way to charge you in some way. But this is a pretty incredible breakthrough and, and it's not something that I've been following, but it seems like everybody's making a big deal about it. So let's figure out why . This says that US scientists have announced a breakthrough in nuclear fusion that could totally transform our energy needs. And this is coming from the Daily Beast. It says, the US Department of Energy announced Tuesday that it has accomplished net energy gain, one of the ma most major breakthroughs in making fusion a viable form of energy. For the first time ever, this milestone expert's hope paves the way for a possible future of unlimited clean energy. Now I'm gonna give you my breakdown cause I watched this release today on, uh, YouTube live of. The US Department of Energy discussing this, and I'm gonna tell you what I think happened and then we'll see how wrong I am  by reading the full article here. So from what I watched today, the US Department of Energy came out and celebrated the fact that they potentially worked out a way to cause a net energy gain in nuclear fusion, which sounds kind of crazy. It's pretty simple what they did. That's not that simple , but it's simple to explain enough to me. What it sounded like they did is they took 192 laser beams all in this small little glass container pointing at a singular spot, the half the size of a bebe. And what their goal was to do was to heat that little half little bebe up to a round 3 million degrees Celsius, and in doing so, they would cause a net gain of energy. which just means that what they did is they put in, let's say you put $1 in on this side of the machine and $2 comes out on this side of the machine. So the amount of energy that they actually put into heating up this BB caused the BB to emit more energy than it had taken in. So 192 laser beams all pointing at this little bebe. And that allowed them to create a, a, a small bebe to turn into as hot as a star and emit so much energy that it could be used for other purposes. And what I believe they said is that it, they put in about two kilo jewels of energy and out on the other side came three kilojoules. So a one point. Times net positive increase in energy from what they put into this that they would get on the outside of that. So you can imagine all of the applications that this could be used for, but that was my interpretation of it. That's what I heard. And this could be used in many ways. Initially it's gonna be used for military applications, I'm sure more than anything, but, and they said that Biden hopes to have this in place, which I'm sure he has so much poll when it comes to nuclear fusion , that this would only take 10 years to be commercial. Which is what this article here is alluding to. And it sounded like we were a bit farther away from that, according to the individual that was the spokesperson for the US Department of Energy, which said that they thought that we were several, several decades away. And then they ev they, the, the journalist on site actually even challenged her and said, well, Biden, you said Biden's goal was 10 years. You're saying it's going to take five, potentially three to five decades before we u utilize this technology. How do you reconcile that difference? She said, uh, and the response was all of, but you know, that's our hope. We really hope to be using this in the future, but we can't say it really is gonna depend on private investors and the private companies coming in and looking to invest into this. Sounds like they had somewhere around the realm of like 55 million or something. Maybe. Maybe it was, yeah. I believe if I recall correctly, it was 55 million. So let's see how right or how wrong I was by reading this article that actually explains it in a way that somebody sat down and wrote it out. So , they said, uh, this is an incredible ex, incredibly exciting result. Said St. Stefani DM, a fusion energy researcher at the University of Wisconsin Madison. She added that the breakthrough demonstrates how investment in modeling and detailed physics understanding is paying off With these recent advances, US Secretary of Energy, Jennifer Granholm, told reporters at a press conference on Tuesday that researchers at the National Ignition Facility at Lawrence Livermore National Laboratory in California were able to produce more energy from a fusion reaction then was required to create it during a December 5th experiment, hence the net energy gain. Now, this says a big quote here was from the White House Office of Science and Technology says that we have taken the first tentative step towards clean energy source that could revolutionize the world. This is a landmark achievement for the researchers and staff of the national IG Ignition facility who have dedicated their careers to seeing fusion ignition become a reality, and this milestone will undoubtedly spark more d. Last week, they shot a bunch of lasers at the app pellet of fuel, and more energy was released from the fusion ignition than the energy of the lasers going in. Wow. I was correct . So, uh, got that one right. Um, Rodi Prab Bahar, policy director for the White House of Office of Sciences and Technology said that the press conference, this is such a tremendous example of what perseverance really can achieve. The experiment used a process called inertial confinement fusion, which was involved, which involved shooting nearly 200 of the world's most powerful lasers at a tiny amount of hydrogen in order to replicate the nuclear fusion reaction that occurs every single moment on the sun. The lasers use 2.05 megajoules of energy to start the reaction resulting in a creation of 3.15 megajoules of energy. That's more than a 153% increase of power. While momentous, there are a few caveats. For one, the reaction lasts to the nanosecond, so it's not quite the constant self-sustaining process that we see play out on the sun. The amount of energy produced was also a mere fraction of what we get from a regular wall electricity outlet. Wow, that's disappointing. , LL and L Director, Kim Badillo also told reporters that researchers are still a few decades away from being able to create a commercially viable fusion reactor. However, this breakthrough is a consequential if somewhat small step towards the ultimate goal of limitless zero carbon energy production. We have taken the first tentative steps towards a clean energy source that could revolutionize the world along with clean energy initiatives. The fusion reaction also paves the way for a slightly more nefarious undertaking, the strengthening of the US national defense infrastructure. Marv Adams, the Deputy Administrator for Defense programs at the National Nuclear Security Administration, explains that the net energy game produced by the N I F helps advance national security in three ways. Um, this says is another large quote here, which says, in a world where we have fought wars over energy, energy, resources, and access to resources used in energy production, fusion brings us hope and an amazing challenge for one that helps defense programs maintain competence without testing nuclear weapons. It also helps bolster our weapons deterrence. The breakthrough also jettisons the US to the forefront of fusion energy research, serving as a signal to both our allies and enemies that we know what we are. I would hope so. . The announcement also included a few slightly mixed signals from the speakers while Bil stressed that there were still decades away from seeing fusion reactors that could be used as a part of widespread energy infrastructures. Grant Holmes said that President Joe Biden envisions a commercial fusion reactor, which in within 10 years, well thank God he won't be around to see that he was wrong. . Uh, however, BiDil explained that while inertial confinement fusion had achieved net energy gain, other types of fusion reactions, specifically magnetic fusion, which much farther along, uh, it says that the foundational technology to begin to scale up towards a power plant is further along than the magnetic fusion community. It's building more directly off the work that's been done in recent decades of facilities like Jet and the United Kingdom, the Princeton Plasma Physics Lab, and. Nevertheless, Beil and her colleagues were bullish on the fact that the latest accomplishment was a major first step in providing out the vi viability of fusion energy for commercial purposes and potentially eliminating the energy woes that have plagued society since the Industrial Revolution. Yeah, it's funny how we didn't have energy woes until we decided to industrialize our culture. . Uh, in a world where we have fought wars over energy, we already read that quote. I'm extremely excited to see what's next in this field as we come to push innovation and drive towards a cleaner, more sustainable and equitable and just future. It's interesting how they can equate it to equity and justice. So as of right now, it means nothing for us at all, other than the fact that they can really heat up a BB for over a nanosecond. But at the moment, this does nothing for us. It does bolster our public outlook. From, like they said, allies and enemies regarding what our science and technology capabilities are and gives hope for the future that we will one day be able to also fly aircraft like the UAPs and UFOs that seemingly just blast off from anywhere in any direction, at any speed that they want at all times without any fear of ever getting rid of their energy source. Hey, that would be cool. All right, so that's what I got on that one. It is pretty cool though, I would say I watching it, it was interesting, you know, looking into the, the, there hasn't been too many large breakthroughs in nuclear science or anything really like this that, that we've heard big, large articles about recently. And so, uh, it is interesting. I'll give them that. And it is interesting to see what we could be able to do with this in the future. However, it seems a little bit farther. Then most people would hope that we're actually gonna be using this unless some people from the private sector step in and start to fund these things for profitable purposes. Because if we know anything about our government, it basically sucks at everything. And every $5 you throw into it, four gets thrown away. And by thrown away, I mean passed on to politicians and then one goes towards the actual entity or thing that you wanted to. And that's a very, very generous percentage that I just gave them there. So . All right. Um, this article comes from the Hill and it says the biggest five, uh, takeaways from the Fusion Energy Breakthroughs. And I'll just read you the headlines in here, which says, it's the first time a net energy gain has come from fusion. That's a cool thing. It's seen as other, another potential source of carbon free energy. Uh, then the next thing it says is breakthrough positions. Breakthrough positions, us or US as leader in global quest for fusion. Fusion still years off from becoming a mainstream energy source, and it has military implications. Hmm. Says, uh, this is a tiny scale version of the same process used to kick off a hydrogen or thermo nuclear bomb, which uses fusion power to release 1000 times as much energy as the bomb dropped on Hiroshima in 1945. That's terrifying. Fusion reactors don't contain nearly enough fuel to produce what kind of ex, uh, that kind of explosion. And a thermonuclear bomb requires a separate atomic explosion to trigger ignition according to the International Atomic Energy Agency. But US officials hinted at military applications, fusion is an essential process in modern nuclear weapons. And a milestone like this one has a strong argument for Amer American military. . The successful test demonstrates America's world leading expertise in weapons relevant technologies, while continuing to show our allies that we know what we are doing. , I like how that's the quote that everybody, we know what we're doing. Like I sure as hell hope. So if you're spending 55 million in, beaming a bunch of lasers at a tiny little bebe to do so. Yeah. Seems, seems like, uh, seems like you should know what you're doing. Anyways, let's go ahead and move on. Uh, this says that, oh, that this says that. I'm gonna take a drink of water. There it is. So much better. This says that Congress introduces a bill to ban TikTok over spying fears. Interesting. How somebody else, I can't exactly recall who, but somebody else seems to have proposed this several years ago for the same exact reason. , but now, apparently, because it's not that. So that, that, that person, um, that so-and-so who did this, uh, now seems to be a good idea because this was a bipartisan effort to ban TikTok. And let's go ahead and read this article, which comes from, uh, in gadget.com. Politicians in the US and house, uh, the politicians in this house and Senate have put forward bills to ban TikTok over worries China could use it to spy on Americans. And then it goes on to say, uh, that American politicians aren't just restricting access to TikTok. They now hope to ban it outright. Members of the house in Santa have introduced matching bills that would block transactions from any social media company in or influenced by China, Russias Cuban, or Cuba, Iran, North Korea, Venezuela, the Anto Antisocial CCP Act. Averting the national threat of internet surveillance, oppression, censorship, and influence, and algorithmic learning by the Chinese comic Party. Wow, that's quite the name. Um, is meant to shut down access to TikTok and other apps that could use theoretically funnel, that could theoretically funnel American user data to oppressive government censor news or otherwise manipulate the public. Who in the world would allow a social media company to use user data to censor news or otherwise manipulate the public? No. Nobody would do that. Not, not, not the Lord and Savior. Mark Zuckerberg, not our man. Jack Dorsey, now formally known as Elon Musk, , CEO of Twitter. Um, we could never imagine the world. And then really it is. That's funny how it is now, just basically Instagram and TikTok or Instagram and Facebook that are the, the per purveyors of.  or welly in truth in the us But the fact that this, this is not being brought to light for our own companies is, is, is somewhat comical too, because literally we just found out that Twitter was actually actively censoring and blocking the active president of United States from utilizing Twitter while he was the sitting president for no reason at all, for no reason. They had no reason at all to do so, so they made one up and that seems like a good, it's absolutely against our first amendment and also is tampering with election outcomes, right? So, so hopefully if this bill is being in, in enacted, we will see some type of backlash for the things that are coming out with Twitter, although likely not because the government, as we also found out, was also involved in these things. So this goes on to say the rational echoes what US political leaders have argued for years. While TikTok has taken efforts to distance its international operations from those in China, such as the storing of US data domestically, critics have argued that parent company bite dance is ultimately at the mercy of the Chinese government. TikTok could potentially profile government workers and otherwise surveil Americans. According to the often repeated claims Republican bill co-sponsors send. Senator Marco Rubio and Mike Gallagher tried to draw links between some bite dance leadership in the Chinese Communist Party in an opinion piece in the Washington Post this November. At the time, 23 directors had previously worked by state backed media and at least 15 employees still did. The bill is also sponsored by House Republican Raja Krishna Mothy, that's quite the last name. K R i s A H N A M O O R T H I, Krishna Mothy. All right. In a statement, a TikTok spokesperson said it was troubling that members of Congress were putting forward legislation to ban the app. Rather than waiting for a national security review to wind down the bills will do nothing to advance national security according to the company. The firm added that that would continue to brief Congress on plans developed under the watch of security officials. The social network has consistently denied plans to track American users, uh, or otherwise deliberately assist Chinese surveillance efforts in the country. TikTok already faces some legal action. The states of Maryland and South Dakota have banned TikTok on government devices over security concerns in Indiana meanwhile sued TikTok for allegedly deceiving users about China's data access and child safety violations. The lawsuit with fine TikTok in demand changes to the services info handling and marketing claims, uh, says that whether or not the bills become legislation is uncertain. President Biden revoked former President Trump's orders to ban TikTok downloads, and instead required a fresh national security review. He's not expecting to override his own order. And while the bill sponsor characterize the measure as bipartisan, it's not clear the call for TikTok ban has enough support to c clench the necessary votes and reach Biden's desk To some degree, the anti-social CCP Act is more of a signal of intent rather than a practical at attempt to block TikTok. Hmm. Yeah. So it, it, Trump already tried this, literally did enact this and banned TikTok because of exactly this reason. And now it's being proposed again on both sides of the aisle. And the only way that it would get enacted is if Biden himself said, oh, you're right. I was wrong. And the likelihood of that happening unless he just forgets where he is and accidentally signs the bill before, I don't know, having to go empty his. Empty his colostomy bag or whatever he, he has his, his depends diapers, um, , I don't think there's much of a chance of this passing, but it is a signal to people. Like it said, it's a message that's being portrayed and, and it's a conversation that's being had around TikTok now pretty consistently as this one of the, as the most threatening social media application. I mean, I don't have it on my phone anymore. Now, I, the, a big piece of that is because I built my account and then got it banned for literally no reason whatsoever. Still have not received a response from them for that, uh, 55,000 people that were following there. But that's a different conversation. In this case, uh, you know, the, when you go through the terms of service, when you look at it, and, and a lot of people have been coming out and talking about this, it is by far the most aggressive application in stealing all of your data. It looks at all the text messages you send, it looks at all of the photos that you have access to on it. It, it basically tracks you everywhere you go. It knows exactly what you're typing into search bars. Every single piece of information that is on your phone can be accessed by TikTok and by the Chinese Communist Party. So, uh, you have to take that into consideration when you understand that the Chinese Communist Party may be our overlords in about 30 years. , and it may, may affect your social credit score that you, uh, I don't know, posted a funny dance on TikTok that got flagged for violence.  anyways, so there's that. Uh, I don't think anything is gonna happen with this, but the fact that it's even being talked about again, is good that it's in the public light and any, any at all pressure on social media companies to be more transparent, to stop collecting as much data, to start pushing our society in a positive direction as, as opposed to one of just straight consumerism and grossness surrounding the, the five to ten second videos that once you realize that you're literally just playing, if, if there was a little lever on the side of your phone that you had to, you know, use like a slot machine every time you wanted to see a new TikTok, I think we would start to look at each other. Pretty weird . It's like you, we are literally, we are absolutely just completely addicted to our phones and not even addicted to our phones at this point. I've talked about this before. It's the monopoly of attention through the large corporations, right? It what the way that the, the internet used to be. 50 50. Geez. It's not been long. 50 years. Um, so the, the way the energy, the, the internet has been or was originally back in the late nineties, early two thousands, even into the late two thousands was, uh, really until we got into social media apps. What, like 2006, 2007, Facebook started to come out. So it, it was the, you could, people would save bookmarks and go to the websites that they wanted to go to. Now people just go on directly to social media to get the feed of everything everywhere, all the time.  and it's this str, you know, shopping mall of information as opposed to going directly to other sources. That's why you have a really big trouble with this downturn of, of, you know, website sales and obviously you had the.com bubble, which, which maybe had a piece of that. But really what you're seeing is a monopoly of attention. And, and you see this everywhere. You see this with our, our food distribution, right? There's a, a Kroger, a Whole Foods, uh, Winn Dixie, and uh, uh, I don't know, whatever, whatever the hell other places there are around this country that you buy food from. But there's usually only one in each area that you go to. , right? The mom and pop shops have a really difficult time even being in the conversation, right? And that's not even bringing up Amazon. Amazon is completely taking over almost every business and being in, in a, a business that utilizes Amazon in some way, shape or form it, it's crazy to find out that Amazon gets its business by basically completely undercutting the businesses that it's buying stuff from. So by being the largest distributor, it also distributed distributes it at the lowest price, leading them to make the profits. And the company who actually came out with the materials and the product itself came up with the ideas, did the marketing, all of that makes less. And so you see this whole conglomeration of, of human collective consciousness that is all streaming through one to five different doors, depending on what you're talking about. If you're talking about food, you go to this place. If you're talking about, uh, Internet, or I'm sorry, talking about news. You go to these three sources. If you're talking about any interaction with any human ever, you go to social media. If you wanna buy anything, literally on the entire world, you go to Amazon, right? All this monopolizing of attention so that the mom and pop shops go away and the people who profit are the ones who are already billion and trillionaires and everybody else goes outta business. And you saw the worst of that when you saw that Target and Home Depot were allowed to be open while mom and pop hardware stores and mom and pop grocery stores were shut down, right? Because they have the biggest lobbying power. So I'm glad to see any one of these big, I'm, I'm really glad to see what's going on with Twitter right now. All of the files that are coming out, the Twitter files right now, I think we're on like. Five or or stage five of those. The things that it's come out with more recently is that Donald Trump was silenced and, and blocked from Twitter for no reason that there was cooperation with the government during that time. Uh, that there was, uh, initial tweets that were being deleted as a result of political affiliations. And then shadow Banning was absolutely real in that there was communications happening back and forth between Biden's team and Twitter during the Hunter Biden laptop situation. Right. And there's more to come. So we'll have to keep our eyes on that too. All right. Now next we're gonna talk about, uh, the, um, ecto life, which is the 30 or the world's first artificial womb. And then another thing I'd like to talk about, we're actually gonna skip the Joe Biden be an old thing cuz that's something we all know. No need to bore you with that. But I did find something on conspiracy Reddit, which I found to be quite interesting and it has since been. Deleted. So more recently, project Veritas came out with a video discussing the dean of a very well known school. Um, the man goes by Joseph Bruno at Francis w Parker School, and he admitted to showing children's sex toys in school during sex ed class thinking, oh, look at this butt plug. Like, look at this dildo. Like it's disgusting. The dean of a school, the dean, not a random 21 year old blue-haired Antifa member that infiltrated the school system. No, this is the dean of a well-known, established private school. All right. Which obviously makes it even more concerning. So let's go ahead and read this and, and now each of these statements come with receipts. So I will include this in this week's podcast companion. All right, which again, go to red pill revolution.co or go to. ck.com, um, or I'm sorry, red pill revolution.dot com, and you can sign up directly through red pill revolution ck.com. All right, so this has just started a deep dive on the private school dean that was showing children how to use sex toys Project. Veritas caught the Dean of students, Joseph Bruno at Francis w Parker School, admitting to showing children how to use sex toys in class. The school has some bizarre policies in place, including segregation from whites from others. The school has come out in strong support of the dean. The incident appears to be a textbook example of grooming. The school is in Chicago and is expensive with many famous alumni, including Anne Hench, who is reportedly investigating child abuse before her mysterious death in Hench has been open about her abuse at a young age. There were also very powerful political connections and billionaires engaged in bazaar missions. They are are connected to Democrat and Republican politicians. All right. Now the first thing is the Project Veritas Undercover video. So let's go ahead and see if we can pull that up first. And this is a video again, just coming directly from Project Veritas on Twitter. Let's see if we can actually get it to pull up for us. Hmm. Looks like it might have gotten deleted. All right, so you can go watch it yourself. Look up, uh, project Veritas, project veritas.com. Project Veritas on Instagram, project Veritas on Twitter. And you can find this video. All right. Uh, but it says that the school completely scrubbed their social media, and it said that this individual who seemed to do a pretty deep dive, and again, every one of these statements has a link backing up its statements here. So I was looking through the list of alumni and donors, and one name jumped out, Pritz. This family of billionaires was very actively in pushing sex ed. The children sex change medical procedures for children. They're invested in many medical companies that make the surgical equipment and meds for sex change operations. They donate to tons of medical associations, medical schools and clinics and hospitals. They have paid their way onto many boards. One member is cur, uh, is the current governor of Illinois. Wow. One member of the family is the current governor of Illinois. Another was the Secretary of Commerce under former, uh, under Obama, and another was a former Hillary Clinton Press campaign manager. The majority of their sex ed sex change activities for youth are coordinated through their nonprofit tawan foundation. The foundation is led by Jennifer Pritzker, formerly James Pritzker. Uh, and here Jay Pritzker is seen speaking as a guest of honor at Francis w Parker School, speaking to students about his transition from male to female. And there's an article about that directly from the school's website. And I got it pulled up right here. Um, it says, military re veteran historian, businesswoman, investor, developer philanthropist, transgender woman, and Parker graduate Colonel Jennifer Pritzker, 68 years old, returned to the school recently to speak at Morning X about the importance of understanding the military's role in a democratic society. Wow. This is not who I want teaching my children, . And that is quite the introduction, by the way. Anyways, let's go ahead and, uh, redone it goes, uh, on to say that Pritzker is also a donor and alumni to the school who's given millions. Note that Pritzker's donation to all sides. Um, literally everyone. Rudy Giuliani, Biden Bush, Alpac, Nikki, Halle, uh, Democrats of Tennessee, Democrats of Texas, R n C, Tammy Duckworth, labor Party, farmer's Party Libertarians. It just goes on and on for decades. It looks like the family is just buying influence from everybody. Here is a very interesting article about Jay Pritzker's involvement in SY synthetic sex identity by an investigative reporter. Balik comes from Tablet Mag. Another family Tom or another family member, Tom Pritzker, was recently revealed to be one of 12 John Doz, uh, being accused of one being one of Jeffy Epstein's and GLA Maxwell's co-conspirators in the underage sex trafficking of young women. Wow. I wonder how, where this association comes from in the family. Uh, the Pritzker family is discussed at three 11 of this video. Tom Pritzker's, Epstein connection is discussed at the start of this video. The family is consistently in USA's top 10 richest family, but asides from Illinois, they have almost zero name recognition, almost as if they're trying to maintain a low profile to avoid scrutiny and inquiry. Chicago Times and Vanity Fair documented several factions of the family's agreed on full display as they went to war with each other when the patriarch died in the late 1990s, even though they had all been left generations worth of wealth. Dean of Students, Joseph Bruno, specifically mentions in the Project Veritas video that he has an unlimited budget and that the administration would not at all be concerned about exposing underage children to at best, inappropriate information. The links I shared are barely the tip of the iceberg of this bazaar network. It goes much deeper and gets much darker. Predictably, there are already articles in MSM that attempt to preemptively shield any criticism notably of j Pritzker as transphobic or anti-Semitic. Some of the links didn't generate property. All right, cool. The very first, uh, thing that goes on to say is, um, have some, a quick few little responses here, uh, is somebody tells them to hide his IP address. . Somebody says Good work. Uh, yeah. Anyways, so interesting that the Dean of students, that project Veritas called out for basically teaching children how to use butt plugs in dildos is related to the Pritzker family, which is related to Jay Pritzker, right? Jay Pritzker was the one with, with, uh, let's see, no, Tom Pritzker, who is related to Tom Pritz. Who is one of the 12 John Doe that was being accused of being one of Jeffrey Epstein's co-conspirators. Wow. That is pretty wild. Now I don't really know what to make of this, but I thought it was an interesting correlation between this guy and this family. Let's go ahead and see if we can actually get a little bit more information about who this guy is. Let's see, the Pritzker family. So it is just talking about, uh, so basically the school was being funded by one of these people that are part of these families. And it's no coincidence that you're somebody who is a part of Jeffrey Epstein's co-conspirators would be trying to groom children at a high school age. Uh, That has since been deleted off of Reddit. You can't, you cannot find that. You cannot find it on, on conspiracy as at least that came from, uh, posted by Bonding Chamber was the name on Reddit. Uh, so go give that person a look and see if they come out with anything, cuz it did look like there was a seat in a certain amount of, uh, information here. That was pretty well, uh, pretty well dug up. So, um, anyways, let's go ahead and move on. The next and final topic that we are going to discuss here is the, uh, ecto, what is it? Ecto Life. Ecto Life is the name of this company. Okay. And let's see if I can even get a company website for you. No. Hmm. All right. Ecto Life had a press release recently saying that they revealed a concept which was the world's first artificial womb facility. So I have a video for this, and then we will go on and read some of this article here and here we go. Introducing Ecto Life. The world's first artificial womb facility, powered entirely by renewable energy. Ecto life allows infertile couple to conceive a baby and become the true biological parents of their own offspring. It's a perfect solution for women who had their uterus surgically removed due to cancer or other complications with ecto life, premature births and C-sections will be a thing of the past. Ecto life is designed to help countries that are suffering from severe population decline, including Japan, Bulgaria, South Korea, and many others. The facility features 75 highly equipped labs. Each state-of-the-art lab can accommodate up to 400 growth pods or artificial wounds. Every pod is designed to replicate the exact conditions that exist inside the mother's uterus. A single building can incubate up to 30,000 lab grown babies per year. Ecto life allows your baby to develop in an infection-free environment. The pods are made of materials that prevent germs from sticking to their surfaces. Every growth pod features, sensors that can monitor your baby's vital signs, including heartbeat, temperature, blood pressure, breathing rate, and oxygen saturation. The artificial intelligence-based system also monitors the physical features of your baby and reports any potential genetic abnormalities. The pods are equipped with a screen that displays real-time data on the developmental progress of your baby. These data are sent directly to your phone so you can track your baby's health from the comfort of your zone. The app also provides you with a high resolution live view of your baby's development. A special section in the app allows you to watch a time lapse of your baby's growth and share it directly with your loved ones. Because babies can recognize language and learn new words while still in the womb. Ecto life Growth Pods feature internal speakers that play a wide range of words and music to your baby. Through the app, you can choose the playlist that your baby listens. You can also directly sing to your baby and make them familiar with your voice before birth. Our goal is to provide you with an intelligent offspring that truly reflects your smart choices. Ecto life improves your bonding experience with your baby, thanks to a 360 degrees camera that's fitted inside your baby's growth pod. You can use your virtual reality headset to explore what it's like to be in your baby's place. See what they see, and hear what they hear. All right. I'm gonna pause that right there and we'll, we'll listen to the rest of this because this is so wild. This company is trying to artificially grow babies in a warehouse, and they spent how many millions of dollars producing this singular video, which is like movie level animation and cinematography, and. Cgi, like they spent so much money producing this video that where do you think this money is coming from? And, and here's another more interesting topic besides the fact that how creepy this video is, because if you have, you gotta see the video because what they're showing you on the screen is like this cgi, like mimicry of what this facility would look like. And they try to make it look all cool and hip and baby pods and like, but you know how, like, how discu could you imagine walking into this facility and seeing 30,000 babies lined up in like a football field arena, just sitting there in a glass jar on a shelf somewhere? And this to me, just tells me exactly where they're trying to go with this. What is a woman. If, if a, if a uterus is no longer magical, is no longer the, the, the, the giver of life and some cold, sterile glass box is where we're gonna grow our children, then the, the, the whole goal of all of this is, is transhumanism. This is transhumanism. Transhumanism is here. It is, uh, if you don't know what transhumanism is, it's basically humans trying to take control of our evolutionary cycle and push it in the direction that we want it to go, not where God wants it to go, not where fate wants it to go, not where the world or evolution needs it to go, but where we are playing God, we as humans are playing God by shoving a bunch of embryo little babies into a warehouse, 30,000 babies deep. As they minimize the, the, the power that is the femininity as they tell you that your uterus and capabilities of carrying children means nothing. Meanwhile, they wanna market to you so they can further commoditize children being born into this world because you know how much this is gonna cost. This, they try and play it off. Like, it's like, oh, this is gonna help Japan who has lowering numbers, and, oh, this is gonna help Venezuela, who's been really having an e Coli breakout, like, fuck no. This is going to benefit the celebrities who are going to pay hundreds of thousands of dollars to have their son be seven four with the jawline of Arnold Schwarzenegger and the right hook of Mike Tyson and have their daughter looking like a Victoria's Secret supermodel walking out of the womb. And they're gonna spend $200,000 on it, and they're gonna give them a, a, a ridiculous sliding scale of IQ and all of the, like, this is going to become a commodity for rich people. And that does not even touch on the potential of this. Because if this is being marketed this way right now, this is already in effect somewhere, in a warehouse in China, in Ukraine, in some, a few skated country that doesn't have real laws surrounding this, that can do whatever the hell they want. This is already happening somewhere that they are growing babies in test tubes. And if you think human trafficking is horrible right now, can you imagine what it's gonna look like when a baby is born, as many babies as you could ever want, is born in a pod, in a glass tube, in a dusty warehouse in Ukraine, and you can buy it.  on the, the, on Amazon and have it shipped to your damn door. And you didn't need love, you didn't need attention, you didn't need a relationship. You don't have any of the foundations of what it takes to be a parent. In order to get this. You just need money. And the people that this is going to heavily affect initially is not going to be the, the, the downfall of Japanese, uh, uh, population. It's going to be the rich and the famous who are capitalizing off of spending hundreds of thousands of dollars to curate a picture. Perfect in high IQ baby with blue eyes and whatever the jaw line of, uh, handsome squidward This is terrifying, really. Cause if you think of it from a human trafficking perspective and, and you understand that this is already happening. You know, if they're spending millions of dollars doing this type of marketing for it, the CGI that goes into this video, you know that this is absolutely some country, some evil super villain somewhere has a dusty warehouse of 30,000 babies all lined up. And what happens if this goes wrong? What if this already went wrong? This is definitely didn't 100% perfectly fucking happen where you're just come out with a baby that looks great. How many, how many, one armed, three nosed, two-headed babies came out of this type of experiment and what happened to those? Because there's no way that they just 100% accuracy fired off this crazy scientific God-like experiment. And we're just supposed to expect that nothing went wrong in the meantime when you were, oh, I don't know, growing test tube babies in a dusty warehouse without any oversight. What? What in the world? Science is becoming like alchemists and dark magic wizardry and dark magic, and that is our today's science between mRNA, gene therapy and test tube babies and bombs a thousand times. The, the efficiency in, in, in size of what we saw in Hiroshima being created. Right now, science has gone rogue, wuhan lab gain of function research. Talk about that again, right? What, where do we draw the line? When, when is it? Because here's what you have to understand. Science is five steps ahead of legislation, if not 10 or 20, right? When you look at leg, leg, leg. When you look at regulatory agencies, when it comes to the financial markets, They are so far behind what is happening in crypto. That's what we're finding out with ftx, right? They're so far behind and they're trying to catch up, and they're trying to make legislation that, that, that helps protect people. And by people, I mean human beings, which is the exact thing that these scientific villains are creating in little baby test tubes in the meantime for proof of concepts so that they can sell them to celebrities so that those celebrities can have hot and smart babies instead of the ones that God intended for them to have. And then all of the weirdness, like, oh, pretend to be your baby in our glass tube with your virtual reality headset. How about, no, how about, I don't wanna do that. How about this is disgusting. And I draw the line at at, at Scientifically Grown test tube babies like nobody, nobody asked for this. Nobody maybe besides Claw Schwab in the World Economic Forum. Nobody wants this. Nobody needs this. And talk about fertility issues. Yeah. Okay. You got, you got a hysterectomy. That's horrible. There's, there's surrogates out there. You don't need to grow a baby in a test tube because how many, how many times? What happens when it does go wrong? Right. What happens when there is an anomaly in their genes like they talked about? What happens when there's an, it's a it, it comes out with three noses. What are they gonna do with that baby? Hmm. And if they're already doing this and somebody gets ahold of this technology, which they will, and some billionaire can, I don't know, like Jeffrey Epstein can grow babies in his basement. And this is commercialized. This technology will be commercialized just like nuclear submarines were sold off from Russia. This technology will eventually hit the black consumer market. The underground grossness. That is the place where people purchase illegal firearms that people purchase. Uh, literally human trafficking occurs in, in drug markets. Like this will be a technology that we will have invented that will never go away. There's nothing you can do about it. And then you will have a future. Jeffrey Epstein growing babies in his basement, all because you wanted to fiddle. Fuck around, trying to see if you could what? Congratulations, you made a baby in the test tube. Now what? Nobody asked for this. Using a wireless haptic suit connected to your baby's growth pod, you'll be able to sense their kicks in the womb and share this experience with your friends and family members. You know how else you can experience haptic feedback in the womb? I don't know. Maybe be pregnant. Where, where did we get this idea that women aren't women? Babies aren't babies coming from women. Women don't gain their power from the ability to literally create life like they are stripping humanity of its sense of humanity. We do not need this at all. We don't need you to, to put a haptic feedback suit on for me to feel my baby kick. You know how I felt? My baby kick. I put my hand on my wife's stomach. That's how you feel a baby kick. You don't put on a haptic feedback suit. You weirdos. Like how? How many of the people at this scientific corporation actually have children? Cause I would venture to say zero. Nobody what? Who wants this? And what stops this from becoming a slave trade, right? If you can literally clone babies in your basement and, and grow humans at will, why not cr cr why? What stops these humans from becoming lower class citizens and what stops us from becoming lower class citizens if they're just that much smarter and more beautiful than us? What stops us from becoming the peasants and they take over the damn world, and now because we weren't grown in the test tube, we're not as good as they are for life, and, and it becomes this whole war like you're, you're, we're, we're causing a domino effect in the future that that was not intended for us. Again, these scientists are acting as if they are gods and nobody asked for. Be able to sense their kicks in the womb and share this experience with your friends and family members. With ecto life, your baby will receive the best nutrients that can support their growth. Each group of pods is connected to two central bioreactors. The first bioreactor contains nutrients and oxygen, which are supplied to your baby through an artificial umbilical. This bioreactor also contains a liquid solution that serves as the amniotic fluid that surrounds babies in the mother's uterus. It's rich of vital hormones, growth factors, and antibodies that sustain your baby's growth and development. Thanks to a system controlled by artificial intelligence, each baby receives custom nutrients tailored to their needs. The second bioreactor is designed to eliminate any waste products produced by the babies. The artificial umbilical cord helps the babies to release their waste products into the second bioreactor. With the help of a delicate layer of engineered enzymes, the second bioreactor can then recycle waste products and turn them back into useful nutrients. This way, the facility ensures a steady and sustainable supply of fresh nutrients to your baby. With ecto life, miscarriage and low sperm count are a thing of the past prior to placing the fertilized embryo of your baby inside the growth pod. In vitro fertilization is used to create and select the most viable and genetically superior embryo, giving your baby a chance to develop without any biological hurdles. It's amazing them. It's amazing seeing them go through so much effort. This huge technological ar virtual reality baby with bio, what did they say? Biowaste and, and nuclear bioreactors and all of this, like AI, techno, you know, what does all of this? A human woman, a human woman's body does literally every single piece of this. It monitors them. It gives them the infor, it gives them the nutrients they need. It, it, it protects them with the am am like it. It does all of that. It already does that. The umbilical cord does not need to be artificial. We already have all of these things taken care of. Thank you. Evolution. Thank you Earth. Thank you God, for creating women, real actual women who can make babies without a Biore react. Just seeing the, the, the, the lengths that they're willing to go to strip us from our humanity is incredible. And if you want your baby to stand out and have a brighter future, our elite package offers you the opportunity to genetically engineer the embryo before implanting it into the artificial womb. Thanks to CRISPR Cas nine gene editing tool, you can edit any trade of your baby through a wide range of over 300 by genetically engineering a set of jeans. The elite package allows you to customize your baby's eye color, hair color, skin tone, physical strength, height, and level of intelligence. It also allows you to fix any inherited genetic diseases that are part of your family history, so that your baby and their offspring will live a healthy, comfortable life free of genetic diseases. Hold it, look and push. Say goodbye to the pain of childbirth and birth related muscle contractions. Ecto Life provides you a safe, pain-free alternative that helps you deliver your baby without stress. The delivery process is smooth, convenient, and can be done with just a push of a button. After discharging the amniotic fluid from the artificial womb, you'll be able to easily remove your baby from the Growth pod. Everything is perfectly designed so you and your partner can enjoy the delivery process. To ensure full transparency, our post delivery free d n paternity test helps you confirm the genetic identity of your baby so you can return home knowing that your baby is genetically yours. You don't have to worry about power cuts or carbon footprint. Ecto life uses, highly efficient, been sitting here with my mouth open this entire time. Their premium package. Choose your baby's eye color and their hair color, and their intelligence and their genital size. With our premium 2.0 package that only costs you an additional 1.7 million. Where does the, where do we step in and just draw the line? How do, how do we wave our hands at science and go, no, thank you. Don't want this one. Let's pass it as humanity. Like we're allowing a, a subsection of culture, of humanity, of humans to determine the evolutionary trajectory of our species without the consent of. What is it? 0.03% of people 0.0 0, 0, 0, 0 0, 0 1% of people have anything to do with this type of scientific, uh, research. And then as a much smaller percentage have anything to do with the, the, the actual enacting of this type of thing. And we're going to allow them to genetically modify babies and test tubes so that you can pick its eye color, like it's a tomagotchi. Like wh where, when do we get a say and, and, and how do we do, do we wave our hands? Do we gotta go back and, and give the, the, the nerds a swirly again  to tell 'em this is not okay. Like, wh wh where, where do we get our. How do we get to say no? As a human species, we draw the line at genetically modifying babies in test tubes without human intervention because we have no idea at all what the implications are of this technology at all. Clean, renewable energy consisting of solar and wind power. The highly advanced pods operate with minimal energy needs, making it easy for your baby to make it to full term without any complications. And for those who want a more convenient solution, ecto life is made accessible so your life can be easier. Thanks to our miniaturized, bioreactors, and long-lasting batteries, you can use ecto life growth pods at the comfort of your home, allowing you to incubate your baby in your building without the need to visit our factory. By owning your special growth pod, you will have the ability to build a happy family, one baby at a time away from any birth complications. The concept of Ecto life facility was designed by bio technologist and science communicator Hasha Melley. It relies on groundbreaking research work that has been conducted by scientists and engineers since 1950s. Tired of waiting for a response from an adoption agency. It's also weird how there's, so there's a few very slight but significant gramer issues in the reading of this script here since 1950s is not a proper sentence. So the amount of money that they spent on this for them to have grammatical errors in their scripting for how this woman is reading this is, is kind of bizarre to me. Since technology that was being developed since 1950s, since the 1950s, I don't know, just seems off to me that such a large production would have misspoken sentences, like wrong scripting that was put out as a result of this. And they even said, you could take this to your home. Like just don't come to our baby factory to get your baby. We're gonna put the baby growth encapsulated directly next to your bed so you can grow a baby. Just like you can grow a monster plant . Like, uh, this is just, I don't even know how to feel. I do know how to feel about it. I'm, I'm appalled. This is the most disturbing thing I have come across in my entire. The fact that we are even contemplating this, the fact that we are even allowing this, the fact that this is not a explosion of outcry regarding this, this disgusting technology that is being unveiled as a baby factory. How many baby factories do you think there are already around the world? And what is gonna happen when there's a baby factory in, in the but underneath Epstein Island, just pumping out babies to be whatever in the world they wanna do with them, where they can even genetically modify that baby to be unbelievably beautiful and intelligent or stupid, completely unsent. , but you have a, a, a 10 model, Victoria's secret model, uh, human that comes out of this without even the ability to speak or think for themselves or with very high levels of agreeableness and very low levels of muscular strength. Like all of the, all of the things that come into play with this. And imagine the world where a government only allows you to do this through their technology and what are they gonna do to this baby to be able to track it moving forward. What if, what if the government's going to ban women getting pregnant and having babies at home? And all you, the only way that you get to allow to have a baby, which again, is already happening in China, where they don't want you to have a boy or a girl. And if you have a girl like you, get one or two babies. And if you have more than that, it was literally they would come knock on your door and take your baby from you. So it's not outside the realm of possibility that a government would intervene in, in the, the, the. The outcome of reproduction. It's already happening. So we're already moving towards this. And, and what about a world where a government only allows you to go through their system to have your baby and every one of those babies that they put out, when the back round algorithm of whatever AI technology is giving your child's sentience in this little test tube that is not from the universe or God, they just, you know, ratchet up a little bit more agreeableness, they ratchet up a little bit more, uh, I don't know, naivety, they ratchet down a little bit more of the, uh, I don't know, um, ability to think for yourself. And they ratchet down depending on what your income level is or your personal intelligence or your social, I, your, your social credit score determines what type of baby you can have. What if that happens? And the, the government is telling you, oh, well, you only have a, a, a four 20 social credit score out of 800. So you don't, you don't, you get an ugly baby that's stupid is under six or is under five six and can barely speak for themselves. That's the only type of baby that you want. But it's the only bit's, the only baby you can get because if you have a baby yourself, we're gonna come grab it from you because it's not an agreeable Americanized test tube baby that you had to pay a hundred thousand dollars for over a loan period for the rest of your life to have a baby. There's a really interesting place that our humanity goes, and by interesting, I mean completely dystopian as a result of this technology being rolled out. If it's even real, and I'm sure it is just based on what we know already they were doing with the chimeras and all, all of this, this, this weird cloning and all of the things that have been going around in the background. So, and, and then there's even like arguments being done based on this that's trying to argue this use case. How disgusting. Now there's an article that comes from science in stuff.com/ecto life dash artificial dash wombs. And you can read a little bit more about this. I will let you do your own research. That is my, that's my thoughts on it. This is disgusting. It's hyper concerning. Um, you know, just looking at this. A brave new world. No, no, a dystopia where you don't have access to children unless you go through the AI algorithms that are being implanted into your children's brain at. , which you have no control over, and they're designing your baby around your social credit score. You know, whatever level of your social credit score, which is really just your level of agreeableness to the government, allows you which type of baby that you get. Do you get a smart one or you get a dumb one? Do you get a pretty one? Or you get a stupid one? You get a tall one or you get a short one, you get an athletic one, or you get a, a weak ass little baby  and it's all based off how, what, what type of that mean tweet that you said about Joe Biden calling him old now. Now you can't have blonde hair, you can only have brown hair and then all of a sudden you, you spoke up about XII and ping and now you can only have red hair  and super, super white pasty skin. Uh, nothing against red-haired, pasty skin people. I'm, I'm pretty close to you. Um, , you can see where this goes. And, and really you can't see where this goes, but you can see how dark it can get, whether it's human trafficking, whether it's social credit, score based babies, whether it's, uh, all of these horrific ideas come to mind, and this is just scratching the surface is what is gonna be the result of this. Totalitarian governments are only allowing you to go through their technologies which have embedded within these children certain qualities that make them good citizens instead of self thinking individuals. So have a baby while you can guys, , have a baby while you can with the same jeans and eye color and hair color and intelligence and athleticism that the good Lord and universe intended for you. And on that note, Thank you guys so much for listening. I appreciate you so much from the bottom of my heart. Head over to Red pill revolution.co and leave a five star review wherever you're at right now. Um, whether you're on Spotify, apple Podcasts, Google Podcast, I don't think anybody uses that, but wherever you are, leave a five star review. Hit the subscribe button, go follow us on YouTube. I have a new Instagram, well, it's my old one, but it's the backup that's doing pretty well right now. Go follow it. The Austin J. Adams on Instagram. Uh, truth social is Red Pill Revolt, a primary account, red Pill Revolt. And that's all I got. All right. Thank you guys so much for listening. If you'd like to donate and help fuel the Revolution, help uh, me to continue the work that I am doing here. Please head over to gsen go.com/red pill revolution. Again, it is give send go.com/red pill revolution. That is the only income that I have from this podcast whatsoever. Um, other than some, uh, slight CK subscriptions. So either become a paid subscriber or head over to, uh, the gifts and go.com/rep revolution. And you can donate there I and my family and you know, I would appreciate it very much. Alright, so thank you guys so much. I hope you have a wonderful, wonderful day and week. Until next time, welcome to the Revolution. Thank you.

We have Dr. Mike Pumphrey back on the podcast with a spring wheat breeding program update. TRANSCRIPTION: https://smallgrains.wsu.edu/wsu-wheat-beat-episode-140/ RESOURCES MENTIONED: WSU Breeding Program https://css.wsu.edu/research/breeding/ Variety Selection & Testing https://smallgrains.wsu.edu/variety/ Weed Resources https://smallgrains.wsu.edu/weed-resources/ Downy brome https://smallgrains.wsu.edu/weed-resources/common-weed-list/downy-brome/ Italian Ryegrass https://smallgrains.wsu.edu/weed-resources/common-weed-list/italian-ryegrass/ Herbicide Resistance https://smallgrains.wsu.edu/herbicide-resistance-resources/ Disease Resources https://smallgrains.wsu.edu/disease-resources/ Rust Resistance https://smallgrains.wsu.edu/disease-resources/foliar-fungal-diseases/ Insect Resources https://smallgrains.wsu.edu/insect-resources/ Hessian Fly Resistance with Mike Pumphrey Podcast episode https://smallgrains.wsu.edu/wsu-wheat-beat-episode-35/ GMOs and CRISPR/CAS with Michael Neff podcast episode https://smallgrains.wsu.edu/wsu-wheat-beat-episode-2/ CONTACT INFORMATION: For questions or comments, contact Dr. Mike Pumphrey via email at m.pumphrey@wsu.edu.

We have two special announcements! Very soon we will be celebrating a decade of DNA Today! That's right, we released our first episode on September 1st, 2012. It also coincides with our 200th episode. We want to mark these milestones with you on the show. So send in your favorite episode. You can write it, or better yet, record a 30-60 second voice memo sharing your favorite episode and why you enjoy listening to the show. After all, our podcast would not be possible without you loyal listeners. That's why we want to celebrate together! Send in your voice memo or written message about your fav episode of DNA Today to info@dnapodcast.com. Deadline is August 27th.Thank you to all you listeners for nominating us in the Podcast Awards, you did it! We have officially been nominated. It's year number 6 being nominated and it might be our third time winning the Best Science and Medicine Podcast Award. BUT that's only going to happen if you check your email inbox for an email from The Podcast Awards with the subject line, “Podcast Awards Final Slate Voting”'. If you got this email you are one of the few that were selected to be a voter. It's imperative that you vote! There is a hyperlink to click to get to the voting page. You do have to quickly log back in. Once you do, select DNA Today in the “Science and Medicine category”, select your other fav podcasts and then Hit the “Save Nominations” button. It's that easy. You have until September 10th to do this, but please do it now if you got the email so you don't forget! Our guest this week is Dr. Sam Sternberg, who is a protein-RNA biochemist and CRISPR expert. He runs a research laboratory at Columbia University, where he is an assistant professor in the Department of Biochemistry and Molecular Biophysics. Sam's lab explores the biology of CRISPR-Cas systems and transposable elements, and develops these systems for genome engineering. In addition to publishing his research in leading journals and speaking internationally, Sam remains actively involved in public outreach and ongoing discussions on the ethical issues surrounding genome editing. Together with Nobel Prize winner Jennifer Doudna, he co-authored a popular science book about the discovery, development, and applications of CRISPR technology. Titled A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution, which chronicles the development of CRISPR and explores bioethical aspects of the technology. Their book was a finalist for the Los Angeles Times Book Prize, and The New York Review of Books called it “required reading for every concerned citizen.”Sam received his B.A. in Biochemistry from Columbia University in 2007 and his Ph.D. in Chemistry from the University of California, Berkeley in 2014. He earned graduate student fellowships from the National Science Foundation and the Department of Defense, and was awarded the Scaringe Award from the RNA Society and the Harold Weintraub Graduate Student Award from the Fred Hutchinson Cancer Research Center. Sam worked as a Scientist and Group Leader at Caribou Biosciences before beginning his independent position at Columbia in 2018, and he is the recipient of the NIH Director's New Innovator Award, and is a Sloan Fellow, Pew Biomedical Scholar, and Schaefer Research Scholar.On This Episode We Discuss:Safety, ethical, regulatory considerations for using CRISPR technology Off target effects Working directly with Nobel Prize Winner Dr. Jennifer DoudnaThe 3 major areas of CRISPR applicationsFertility research Animal studies Human genetics Enter our giveaway for your own copy of A Crack In Creation through our social media! For updates on the Sternberg lab, visit their website or follow Sam on Twitter and LinkedIn! You can also read one of his most recent papers on the profiling of CRISPR RNA-guided transposition products here. Stay tuned for the next new episode of DNA Today on August 26th, 2022! New episodes are released on Fridays. In the meantime, you can binge over 195 other episodes on Apple Podcasts, Spotify, streaming on the website, or any other podcast player by searching, “DNA Today”. Episodes since 2021 are also recorded with video which you can watch on our YouTube channel. DNA Today is hosted and produced by Kira Dineen. Our social media lead is Corinne Merlino. Our video lead is Amanda Andreoli. See what else we are up to on Twitter, Instagram, Facebook, YouTube and our website, DNApodcast.com. Questions/inquiries can be sent to info@DNApodcast.com. PerkinElmer Genomics is a global leader in genetic testing focusing on rare diseases, inherited disorders, newborn screening, and hereditary cancer. Testing services support the full continuum of care from preconception and prenatal to neonatal, pediatric, and adult. Testing options include sequencing for targeted genes, multiple genes, the whole exome or genome, and copy number variations. Using a simple saliva or blood sample, PerkinElmer Genomics answers complex genetic questions that can proactively inform patient care and end the diagnostic odyssey for families. Learn more at PerkinElmerGenomics.com. (SPONSORED)

We have two special announcements!Very soon we will be celebrating a decade of DNA Today! That's right, we released our first episode on September 1st, 2012. It also coincides with our 200th episode. We want to mark these milestones with you on the show. So send in your favorite episode. You can write it, or better yet, record a voice memo sharing your favorite episode and why you enjoy listening to the show. After all, our podcast would not be possible without you loyal listeners. That's why we want to celebrate together! Send in your voice memo or written message about your fav episode of DNA Today to info@dnapodcast.com. Deadline is August 27th.Thank you to all you listeners for nominating us in the Podcast Awards, you did it! We have officially been nominated. It's year number 6 being nominated and it might be our third time winning the Best Science and Medicine Podcast Award. BUT that's only gong to happen if you check your email inbox for an email from The Podcast Awards with the subject line, “Podcast Awards Final Slate Voting”'. If you got this email you are one of the few that were selected to be a voter. It's imperative that you vote! There is a hyperlink to click to get to the voting page. You do have to quickly log back in. Once you do, select DNA Today in the “Science and Medicine category”, select your other fav podcasts and then Hit the “Save Nominations” button. It's that easy. You have until September 10th to do this, but please do it now if you got the email so you don't forget! Can't thank you all enough! Special shoutout to the following listeners for sharing after they nominated us…Heather, Dan, Janelle, Steven, Doug, Lynn, Taila, Lorraine, Katherine, Barbara, Jerry, Catherine, Kim, Ashlyn, Pricilla, Jane, Rob, Hari, Vishnu, Leticia, Meli, Wright, Mahfuz, Anne, Laura, Molly, Hibat, Rachael, Carol, Hal, Romer, JoanneJoining us this week is Dr. Kiana Aran, Associate Professor of Medical Diagnostics and Therapeutics and head of the Aran Lab at Keck Graduate Institute (KGI) where she works to develop CRISPR Quality Control standards.In addition to her important work at KGI, Dr. Aran is also the Chief Scientific Officer of Cardea Bio, is a visiting Assistant Professor at UC Berkeley, and serves as a Consultant of Drug Delivery and Medical Diagnostics for the Bill & Melinda Gates Foundation. She received her undergraduate degree in electrical engineering from the City University of New York in 2007 and her Ph.D. in Biomedical Engineering at the Rutgers University in 2012. She then continued her postdoctoral studies in bioengineering at the University of California, Berkeley and was a recipient of the National Institutes of Health (NIH) postdoctoral training fellowship at the Buck Institute for Aging Research in 2015. Her efforts have been recently recognized by many awards in science and STEM including the Clinical OMICs 10 under 40 Award and the Athena Pinnacle Award. Dr. Aran was also the recipient of the NSF Career Award to develop the next generation of electronic sensors, and Nature's Scientific Achievment Award in 2021.On This Episode We Discuss:What is CRISPR and how does it work? How CRISPR is different from other genetic editing technologiesCurrent standards for therapeutic applications using CRISPRPotential side effects of CRISPR treatmentsThe risk for off target CRISPR'd edits (edits in other genes that were not intended)The CRISPR Quality Control standards that Dr. Aran's lab is developingCRISPR-ChipTMApplications of CRISPR-Cas systems beyond genome editingPredicting when CRISPR treatments will be clinically available outside of studiesCRISPR babiesDr. Aran's most recent NIH grant and future workLearn more about Dr. Aran's research by visiting aranlab.org and read about her 1.63 million dollar NIH grant to help set Quality Control Standards for CRISPR Therapies! You can also read the paper that she co-authored in The CRISPR Journal about applications of CRISPR-Cas systems beyond genome editing in 2021. Follow Dr. Aran on Twitter and LinkedIn, and follow the Aran lab on Instagram!Stay tuned for the next new episode of DNA Today on August 19th, 2022 where we'll be joined by Sam Sternberg, co-author of A Crack in Creation (who he wrote with Nobel Prize winner, Jennifer Doudna), to continue our discussion about CRISPR! New episodes are released on Fridays. In the meantime, you can binge over 195 other episodes on Apple Podcasts, Spotify, streaming on the website, or any other podcast player by searching, “DNA Today”. Episodes since 2021 are also recorded with video which you can watch on our YouTube channel. DNA Today is hosted and produced by Kira Dineen. Our social media lead is Corinne Merlino. Our video lead is Amanda Andreoli. See what else we are up to on Twitter, Instagram, Facebook, YouTube and our website, DNApodcast.com. Questions/inquiries can be sent to info@DNApodcast.com. PerkinElmer Genomics is a global leader in genetic testing focusing on rare diseases, inherited disorders, newborn screening, and hereditary cancer. Testing services support the full continuum of care from preconception and prenatal to neonatal, pediatric, and adult. Testing options include sequencing for targeted genes, multiple genes, the whole exome or genome, and copy number variations. Using a simple saliva or blood sample, PerkinElmer Genomics answers complex genetic questions that can proactively inform patient care and end the diagnostic odyssey for families. Learn more at PerkinElmerGenomics.com. (SPONSORED)

Soon women will be able to reproduce on their own. This statement may scare some of you or may be comforting to know, but it's all thanks to the power of stem cells. I have with me an esteemed guest Dr. Alessandro Prigion on the show this week. Dr. Alessandro Prigion is a professor of Pediatric Metabolic Medicine at the Medical Faculty of Heinrich Heine University in Dusseldorf, Germany and Editor-in-Chief of the journal Stem Cell Research (Elsevier). He's the person you talk to when you need to learn anything about stem cells. In this episode we discuss:

Today we talk about mad scientists messing around with power they have no business having, then we tangent on how nobody on earth should have power over anything but their own self. it gets dark.    Don't @ me Jurassic Park  Join the discussion for once! Check out our videos (more coming soon)  Buy us a CRISPR CAS-9

Schmude, Magdalenawww.deutschlandfunk.de, Forschung aktuellDirekter Link zur Audiodatei

Imagine if Jurassic Park came to life...ACTUAL REAL LIFE.  It wouldn't be the first time science fiction became reality. (Hello .space travel)  But, this time, instead of T-Rex and Velociraptors, you've got long-extinct woolly mammoths roaming the arctic tundra, and the more recently extinct passenger pigeons filling the skies.  This is the ambitious dream of scientists George Church (Harvard, MIT) and Ben Novak (Revive & Restore)... but is it even remotely possible? Not everyone thinks so, including our guests Mikkel Sinding and Amy Fletcher.  Thirty years ago, when the original Jurassic Park came out, genome sequencing and CRISPR CAS 9 - the gene editing technology - didn't exist.  Now that they do, does it mean woolly mammoths are  within reach?  We discuss the why's and how's with our brilliant guests. And, hear about a little known connection George Church has to his one time student,  Michael Crichton, the author of Jurassic Park. Don't forget to leave us a five star review if you loved us as much as we think you did.   Check out the work of our brilliant guests:George ChurchBen Novak Lead Scientist, Revive and RestoreAmy Fletcher's Ted Talk on De-ExtinctionMikkel Sinding  Follow us on social media. We're nice. We want to get to know you.InstagramTwitterFacebookTiktokSign up four newsletter and check out our blog  

Gene editing with CRISPR/Cas, TALEN or other tools allows scientists to make directed and precise changes in DNA.  The technologies promise to transform agriculture and medicine. But the application of these technologies hinges on consumer sentiment. Dr. Brandon Mc Fadden is an agricultural economist that specializes in understanding what makes consumers tick. We have a conversation about gene editing, public sentiment, and how it varies between agriculture and medicine. 

Eugene Koonin is the leader of the Evolutionary Genomics Group at the National Center for Biotechnology Information (NCBI) at the NIH. His group is engaged in research on genome evolution, especially in microbes and viruses, host-parasite coevolution, in particular, functions and evolution of CRISPR-Cas systems, and general physical theory of evolution. He received his Ph.D. in Molecular Biology in 1983 from the Department of Biology, Moscow State University. Eugene joined the NCBI in 1991 as a Visiting Scientist and became a Senior Investigator in 1996. He published the book “The Logic of Chance: The nature and origin of biological evolution” (2011) and founded Biology Direct, an Open Access, open peer-review journal. He is a Fellow of the American Academy of Arts and Sciences, American Academy of Microbiology, a member of the National Academy of Sciences of the USA, a Foreign Associate of the European Molecular Biology Organization, and Academia Europea, and Doctor Honoris Causa of Universite Aix-Marseille (France) and Wageningen University (The Netherlands). FIND EUGENE ON SOCIAL MEDIA Facebook ================================ SUPPORT & CONNECT: Support on Patreon: https://www.patreon.com/denofrich Twitter: https://twitter.com/denofrich Facebook: https://www.facebook.com/denofrich YouTube: https://www.youtube.com/denofrich Instagram: https://www.instagram.com/den_of_rich/ Hashtag: #denofrich © Copyright 2022 Den of Rich. All rights reserved.

Show notes: In this episode, The Bio Busters Podcast professors, Dr. A and Dr. C and Dr. K, discuss coronavirus updates, a new study documenting the use of CRISPR-CAS to treat amyloidosis, the “twisties” or the “yips”, and have a new riddle! Keep the discussion and comments going on in the comments sections, or feel free to e-mail the podcast with future show ideas and thoughts on the current show. If you think you know the answer to our riddle, please email us for a chance to win a prize! Email us at thebiobusters@gmail.com   Instagram Link: https://www.instagram.com/thebiobusterspodcast/ DailyMotion Video Link: https://www.dailymotion.com/thebiobusterspodcast Spotify Audio Link: https://open.spotify.com/show/7tY7H11OHUOkBsLP0grTym TuneIn Audio Link: https://tunein.com/podcasts/Science-Podcasts/The-Bio-Busters-Podcast-p1499063/ YouTube Video Link: https://www.youtube.com/channel/UC22s6yGXwduO7BhS32v3Wdg Podbean Audio Link: https://thebiobusters.podbean.com/​ Amazon Music Link: https://music.amazon.com/podcasts/00fc7f18-43f7-4f6b-b416-906335918e72/the-bio-busters Branding: https://www.andsowedesign.com/​​ References: Birthday https://www.todayinsci.com/8/8_26.htm Coronavirus numbers https://www.worldometers.info/coronavirus/#countries https://ourworldindata.org/covid-vaccinations?country=USA Vaccine data https://www.nytimes.com/live/2021/08/25/world/covid-delta-variant-vaccine This episode's scientific study https://www.nejm.org/doi/full/10.1056/NEJMoa2107454 Metabolism https://www.medicalnewstoday.com/articles/adult-metabolism-remains-stable-until-60-study-reveals#Doubly-labeled-water Twisties https://www.livescience.com/simone-biles-what-are-twisties.html Chronic Wasting Disease https://www.cdc.gov/prions/cwd/index.html