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Sorry for the delay!Check us out on Youtube!Also check out Eachus on IG: daneachusFollow our Instagram: swallowdaddysSubscribe to Youtube: https://www.youtube.com/@SwallowDaddysFollow RJ: rj_sainsFollow Drew: drewbockkindofJoin Patreon for Early Access and Bonus Content: https://www.patreon.com/swallowdaddys
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.13.528363v1?rss=1 Authors: Choi, M.-K., Cook, A., Eachus, H., Tochwin, A., Kuntz, S., Kim, S., Ryu, S. Abstract: Chronic or severe stress exposure during development primes an individual for altered stress sensitivity in adulthood and increases psychiatric disease susceptibility. However, the identity and function of genes affected by developmental stress exposure are poorly understood. Here, we used an optogenetic zebrafish model to identify brain-wide molecular alterations caused by chronic Glucocorticoid (GC) exposure during development and following subsequent exposure to an acute stressor in adulthood. We show that developmental GC-exposed fish display wide-ranging behavioral changes affecting social behavior, food consumption, and associative learning. The brain transcriptome of GC-exposed fish showed alteration of genes associated with DNA metabolism, axon development, and social behavior-related genes such as oxytocin across the life course. Strikingly, when GC-exposed fish were subjected to a stress challenge in adulthood, they showed exaggerated endocrine responses and a great number of brain-wide transcriptional changes, including gene sets associated with axon development, neuronal signaling, and epigenetic modulators. These altered gene sets showed an overrepresentation of genes linked to human psychiatric disorders. In short, our study provides a unique resource of long-term, time-dependent gene expression changes induced by developmental GC-exposure and identifies novel GC-primed genes which may shape adult responses of early life stress-exposed individuals. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.09.507267v1?rss=1 Authors: Nagpal, J., Eachus, H., Lityagina, O., Ryu, S. Abstract: Organisms respond to stressors through a coordinated set of physiological and behavioural responses. Zebrafish provides an opportunity to study conserved mechanisms underlying the stress-response that is regulated largely by the neuroendocrine Hypothalamus-Pituitary-Adrenal/Interrenal (HPA) axis, with glucocorticoids (GC) as the final effector. In this study, we evaluated the effect of chronically active GC signalling in early life on the baseline and stress evoked GC(cortisol) levels in larval zebrafish. To this end, we employed an optogenetic actuator, Beggiatoa photoactivated adenylyl cyclase, expressed in the interrenal cells of zebrafish and demonstrate that its chronic activation leads to hypercortisolaemia and dampens the acute-stress evoked cortisol levels, across a variety of stressor modalities during early life. This blunting of stress-response, a phenotype reported by many studies to be observed in human subjects exposed to early-life trauma, was conserved in ontogeny at a later developmental stage. Furthermore, we observe a strong reduction of proopiomelanocortin (POMC)-expressing cells in the pituitary as well as global upregulation of FKBP5 gene expression, impinging on the negative feedback regulation elicited by elevated cortisol levels. Going forward, we propose that this model can be leveraged to tease apart the mechanisms underlying developmental programming of HPA axis by early-life stress and its implications for vulnerability and resilience to stress in adulthood. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer
Welcome to the show, Ben Eachus! Ben is a tech CEO in Southern California by way of Southern New Jersey. A Princeton grad, Ben is pretty smart. He's also talented, ambitious, and not afraid to take a gamble! Back in 2017 while working for Jessica Alba's Honest Company, Ben ran into a problem: He needed short-term warehouse space in a BIG hurry and had absolutely no idea where to find it. Brokers didn't want the gig since it wasn't going to pay a big commission and information for this requirement was nowhere to be found online. Instead of lamenting the problem, Ben chose to solve it by creating his company, Flowspace. Originally a digital marketplace to marry-up warehouse owners with short-term occupiers, Flowspace has grown into a true third-party logistics (3PL) company, offering a wide variety of fulfillment, storage, and integrative solutions for its customers. The company is growing at a great clip and now has over 70 employees! Ben's big bet paid off! Check out Flowspace at www.flow.space
Despite going through a rough patch during the initial hard lockdown in South Africa, Dawn Wing couriers says it has since seen a significant surge in e-commerce. “The lockdown period business was really tough as volumes were low, but we made a decision to stay open to support our healthcare customers,” says Dawn Wing chief customer officer Hilton Eachus. “That said, post lockdown revenue has increased sharply by more than 40% off the back of aggressive growth in e-commerce and strong trade from our healthcare customers.” Eachus says Dawn Wing has spent a “a lot of time and energy” investing in the e-commerce and healthcare sectors over the years and now serves many customers in both these sectors. “Of course, most of our healthcare customers have continued to trade strongly throughout recent months, but we’ve seen an unprecedented growth in e-commerce with volumes 40% up on Black Friday peak volumes and more than 60% up on normal pre-lockdown trade.” Eachus says parcel volumes are up roughly 50% compared with pre-Covid levels. “Interestingly we’ve seen a shift to regional delivery areas and our cheaper services seem a more popular choice, which is expected given the economic pressure everyone is under. Actual parcel sizes, however, have remained constant,” he adds. “We’ve also seen some polarisation of service choice in recent months with some customers opting for slower cheaper services to protect their cost, and others opting for same-day and on-demand services. “As a result next-day services have lost out a bit, which is to be expected given the reduced flight availability from the airlines. We expect this to normalise somewhat in the coming months as flights become available again.” Eachus says absolute profit has also increased owing to the strong growth in revenue, but notes that margins in the logistics space are certainly under pressure across the board owing to excess market capacity. “We’re working hard to ensure we run the business as optimally as possible in order to continue to generate good returns.” The increase in business has seen Dawn Wing add 25 vehicles and three new hubs in Kimberley, Harrismith, and Klerksdorp since the start of the Covid-19 pandemic in South Africa. “We’ll add further hubs in Swellendam, Moorreesburg, and Middelburg in the coming months,” says Eachus. Dawn Wing currently runs 350 of its own vehicles. The company has 16 hubs around the country. “We believe e-commerce has finally arrived in South Africa and is now here to stay,” notes Eachus. “We made a decision over seven years ago to invest in this sector and we’re glad that it’s paid off for us as we are reaping the reward. That said we believe we’ve only seen the tip of the iceberg in terms of what’s to come in this space and we’re excited to be part of it for the long term.”
Increased demand signals and rapidly changing customer expectations are just some of the challenges companies face when determining their fulfillment strategies. With the added disruption of a global pandemic like Covid 19, businesses have to consider other ways to meet those expectations and keep the supply chain in motion. Ben Eachus, Co-Founder and CEO of Flowspace, joins us to talk about a few ways to optimize your fulfillment strategy. FOR MORE INFORMATION: https://www.flow.space/ WANT TO RESPOND TO THIS EPISODE? Call our Dialog Line: 888-878-3247 DOWNLOAD THE NEW INBOUND LOGISTICS APP featuring the updated and expanded Logistics Planner! Available on iTunes and the Google Play Store: http://bit.ly/ILMagApp http://bit.ly/ILMagAppGoogle Are you a #logistics Thought Leader that would like to be featured on the Inbound Logistics Podcast? Connect with me on Twitter: @ILMagPodcast Email me: podcast@inboundlogistics.com Connect with Inbound Logistics Magazine on LinkedIn: https://www.linkedin.com/company/inbound-logistics Follow us on Twitter: www.twitter.com/ILMagazine Like us on Facebook: www.facebook.com/InboundLogistics Catch our latest videos on YouTube: www.youtube.com/inboundlogistics Visit us at www.inboundlogistics.com
Getting the message out about your business is important; getting the message out during a crisis is critical. Rebel Graphix is open for business and are the folks responsible for those cool inspirational signs popping up all over Baton Rouge. Mark Vincent and Jaimee Eachus of Rebel Graphix join Red Stick Strong to talk about reaching out as a business, delivering encouraging words, and the importance of communication. Business owners will gain a lot of ideas about how to stay in touch with the community on this episode. REBEL GRAPHIX IS OPEN FOR BUSINESS: Check out the Rebel Graphix website here: https://rebelgraphix.com/ Email Rebel Graphix—this is the one stop contact for the team: info@rebelgraphix.com Give Rebel Graphix a phone call: 225.387.4634 FOLLOW REBEL GRAPHIX ON SOCIAL MEDIA: Instagram for Rebel Graphix: https://www.instagram.com/rebelgraphix/ Rebel Graphix on FB: https://www.facebook.com/rebelgraphixbr Red Stick Strong is a podcast highlighting Baton Rouge business serving customers during the pandemic. Hosted by Catherine O'Brien and produced by Branch Out Programs. Follow Red Stick Strong on Instagram. Do you know a BR business that needs a shout-out? Tell Catherine!
In celebration of May being Mental Health month, we wanted to start it off with an interview with a mental health professional. Tom Eachus runs the Black Hawk-Grundy Mental Health Center.
Their sidekick and best pal Snoof has been ensnared by Eachus, Minos, and the fearsome Rhadamanthus, the lords of the underworld, and is being put through some trial. Our heroes regroup with their few remaining friends and debate the path ahead. They're nearly in the glowing presence of the battle at the center of creation and time is running out...
Sean G is back in the building holding down the CPU podcast with Alex Conn! His guests are actor and comedian Tom Clark (@tomclarkcomedy) and national headliner Daniel Eachus (@daneachus).Video Versions of the podcast available at https://tinyurl.com/y4eb3f99https://www.instagram.com/comedypopuphttps://www.instagram.com/cpupodcasts for more information about upcoming shows and our podcast network. www.ComedyPopUpLA.comFacebook: https://www.facebook.com/ComedyPopUpLA/WANT TO ASK COMEDY POP-UP A QUESTION/SHARE A STORY/LEAVE A COMMENT? Send an email to: comedypopup@gmail.com
Sean G is back in the building holding down the CPU podcast with Alex Conn! His guests are actor and comedian Tom Clark (@tomclarkcomedy) and national headliner Daniel Eachus (@daneachus).Video Versions of the podcast available at https://tinyurl.com/y4eb3f99https://www.instagram.com/comedypopuphttps://www.instagram.com/cpupodcasts for more information about upcoming shows and our podcast network. www.ComedyPopUpLA.comFacebook: https://www.facebook.com/ComedyPopUpLA/WANT TO ASK COMEDY POP-UP A QUESTION/SHARE A STORY/LEAVE A COMMENT? Send an email to: comedypopup@gmail.com
Process Engineer and Project Manager, Brad Eachus drops by the podcast to talk about saving voicemails, the reenactment of a Taylor Swift demo, free writing, brain dumping, wearing a lot of hats, making semiconductors, living in Kentucky for a few months, a Cracker Barrel tour with Opa, bonding with his brothers, finding out what an engineer really does, meeting his wife in an AP class, being in the right place at the right time, interacting with kids, self-employed artist vs. corporate engineer, working in the same building as his wife, gene expression, the potential for regret, working on the biggest fire, and something about broccoli.
On this episode, Paul Antonio (@ThePaulAntonio) welcomes Nick Vatterott (@NickVatterott) and Daniel Eachus (@DanEachus) to the show to talk about the ever changing landscape of comedy and their "Nipples of View".Follow Comedy Pop-Up @ComedyPopUp and @CPUPodcasts for more information about upcoming shows and our podcast network. www.ComedyPopUpLA.comFacebook: https://www.facebook.com/ComedyPopUpLA/WANT TO ASK COMEDY POP-UP A QUESTION/SHARE A STORY/LEAVE A COMMENT? Send an email to: comedypopup@gmail.com
On this episode, Paul Antonio (@ThePaulAntonio) welcomes Nick Vatterott (@NickVatterott) and Daniel Eachus (@DanEachus) to the show to talk about the ever changing landscape of comedy and their "Nipples of View".Follow Comedy Pop-Up @ComedyPopUp and @CPUPodcasts for more information about upcoming shows and our podcast network. www.ComedyPopUpLA.comFacebook: https://www.facebook.com/ComedyPopUpLA/WANT TO ASK COMEDY POP-UP A QUESTION/SHARE A STORY/LEAVE A COMMENT? Send an email to: comedypopup@gmail.com
Daniel Eachus is a rising young star in the comedy world. Even at such a young age, Eachus has the chops of a comedy veteran and people are taking notice. Born and raised in Fresno, CA, he was surrounded by farms, but didn’t want to smell raisins for the rest of his life, so he turned to comedy to get him out. For college, Daniel’s wish came true and he left Fresno to study in Long Beach. By day, he was a student, by night he performed on the stand-up comedy circuit. After just one year of nightly performances, he became the youngest finalist ever in the “Funniest Comic in Los Angeles” contest held at the Jon Lovitz Comedy Club. He’s been entertaining audiences ever since. Eachus has been performing stand-up and improv throughout the nation’s clubs and recently was featured on Comedy Central’s “Up Next” and Sirius XM’s Comedy Central Radio. A finalist or winner in scores of comedy competitions including the World Series of Comedy, Up Next Regionals, Sacramento Comedy Festival (1st place winner), OC Improv Cup and more, he’s considering expanding his trophy shelf. But doing stand-up and improv is not enough for Daniel. When he’s not onstage making people laugh, he’s making people laugh at their screens. Daniel acts, writes, and produces the comedy sketch series, “Bigfoot Chasers”. He is a co-writer on a brand new Kevin Hart-Produced Series. He’s starred in 12 National Television Commercials, was featured on SpikeTV, and recently made his stand-up television debut on Fox and Hulu's “Laughs”.
Josh Eachus, PhD-- weatherman extraordinaire for WBRZ, is closing in on the end of his third Dog Days of Summer campaign with Friends of the Animals BR. We talk to Dr. Josh about the campaign, about working for a company that is community focused, and even get a great weather scoop! Listen, share, and enjoy the Pawcast podcast.
Nate Eachus, Former NFL Player & AAA State Wrestling Champion; Ron Solt, Former All-Pro NFL Player; and Terrence Shenfield MS, RRT-ACCS, RPFT, AE-C in studio with Frank Andrews about Pennsylvania Community Medical Cannabis Forums Presenting at the Holiday Inn East Mountain, Wilkes-Barre on Thursday, december 7, 2017 at 6PM.
Cancer diagnostics researcher and knitter, Caitlin Eachus stops by the podcast to talk about older Justin Timberlake, the giant tissue deli slicer, Forensic Files, which cancer treatments are so hot right now, cellular typos, the placebo effect, her doppelgänger niece, genetic obedience, getting a lab coat, her one B in high school, teacher politics, selling ovens and incubators, being voted Prom Queen alongside her future husband, avoiding the words 'boyfriend' and 'fiancé', her Year of Failed Sweaters, the comfort of Catholic church, human evolution, low-sodium diets, mass production, robots that fix your robots, communicating in emojis, and whether cats are aliens.
This week’s show celebrates simple human friendship, whether that be expressed with a firm shake of the hand, a slap on the back or perhaps even, perish the thought, a hug. We have some borderline terrifying children singing about Jesus, … Continue reading →
Daniel Eachus is a dedicated funny comic who I beleive has a very bright future. I love comics with passion and he is a man with passion for the craft. We discuss writing before he did the feature set at the Rib Joint. Duke Fightmaster Evan Cassidy