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Dans cet épisode, le Dr André Tricot, psychologue spécialisé en formation et chercheur, se joint à Adam pour explorer en profondeur la théorie de la charge cognitive. Ils discutent des répercussions de cette théorie sur l'enseignement et l'apprentissage de différents groupes d'âge dans des contextes variés, dont celui de la formation médicale en particulier. Ils se penchent aussi sur des stratégies pour optimiser l'apprentissage, sur le rôle essentiel de l'attention ainsi que sur l'incidence de la surcharge et de la « sous-charge » cognitives sur le rendement – et les erreurs – d'experts et d'expertes. Durée de l'épisode : 56:04 Ressources à consulter Read, D. W., Manrique, H. M. et Walker, M. J. (2022). « On the working memory of humans and great apes: Strikingly similar or remarkably different? » Neuroscience & Biobehavioral Reviews, 134, 104496. Kristin Fraser sur la théorie de la charge cognitive et la simulation en formation médicale Fraser, K., Ma, I., Teteris, E., Baxter, H., Wright, B. et McLaughlin, K. (2012). « Emotion, cognitive load and learning outcomes during simulation training ». Medical education, 46(11), 1055-1062. Sweller, J., Van Merrienboer, J. J. et Paas, F. G. (1998). « Cognitive architecture and instructional design ». Educational Psychology Review, 10, 251-296. Fraser, K., Huffman, J., Ma, I., Sobczak, M., McIlwrick, J., Wright, B. et McLaughlin, K. (2014). « The emotional and cognitive impact of unexpected simulated patient death: a randomized controlled trial ». Chest, 145(5), 958-963. Coordonnées : keylime@collegeroyal.ca Suivre le Dr Adam Szulewski : https://x.com/Adam_Szulewski
Last week, Columbia capitulated to Trump's extensive demands on the university, in hopes of recovering $400 million in government funding that was revoked by the Trump administration. Almost a week later, there is still no indication that Columbia will get the money back. The university has agreed to a long list of changes, among them the creation of a new 36-officer campus police force with the power to arrest students; the adoption of the IHRA definition of antisemitism, which conflates anti-Zionism and antisemitism; broad commitments to disciplinary action for student protesters; and even the advancement of Columbia's Tel Aviv Center. Strikingly, the university has placed the Middle Eastern, South Asian, and African Studies department into what the Trump administration is referring to as “receivership,” appointing a new senior vice provost to exert control over the teaching of Israel/Palestine in particular, starting with the Center for Palestine Studies. Meanwhile, the university committed to “the expansion of intellectual diversity among faculty,” indicating that they are going to hire more Zionists to teach in the Institute for Israel and Jewish Studies and in the School for International and Public Affairs. All of this follows the targeting and abduction of Columbia students, including Palestinian green card holder and student activist Mahmoud Khalil, who remains in ICE detention, and Ranjani Srinivasan, an Indian student who was not significantly involved in protests and who fled to Canada to avoid detention after her visa was revoked. It's hard to overstate the significance of Columbia's surrender, at a moment when the US appears to be in democratic freefall, and when academic freedom and the fundamental right to free speech hangs in the balance. Editor-at-large Peter Beinart and Columbia professor Nadia Abu El-Haj, who also serves as the co-director of the Center for Palestine Studies, spoke just hours before this shocking development, but their conversation probes what's been happening at Columbia and Barnard, and what's at stake—both for the study of Israel/Palestine and for the future of higher ed. This conversation first appeared in the Beinart Notebook on Substack.Thanks to Jesse Brenneman for producing and to Nathan Salsburg for the use of his song “VIII (All That Were Calculated Have Passed).” ARTICLES MENTIONED AND FURTHER READING: “‘Mahmoud Is Not Safe,'” Nadia Abu El-Haj, New York Review of Books“The Columbia Network Pushing Behind the Scenes to Deport and Arrest Student Protesters,” Natasha Lennard and Akela Lacy, The InterceptLetter from Mahmoud Khalil from ICE detention in Louisiana“The Perils of Universities' Unscholarly Antisemitism Reports,” Peter Beinart, Jewish Currents“
Mikey Madison is up for an Oscar for her role in Sean Baker's Palme d'Or-winning film “Anora.” The story follows a sex worker from Brooklyn who meets and marries the son of a Russian oligarch. But their fairytale romance is threatened after news of their shotgun wedding reaches his parents in Russia. A few months ago, Mikey sat down with Tom Power to talk about her deep research and preparation for the role, why she feels protective of her character, and how the film changed her life.
When we read the birth narratives of Jesus, we see that God chooses to work through human beings to bring about His plan of salvation. Zechariah, Elizabeth, Mary, and Joseph are the stars of the show. When the child comes, he is a human being too. Strikingly absent from Scripture is any indication that the baby had dual natures or was a hybrid “God-man.” Instead, God ordained that a man would be born to save mankind—an exciting truth worth celebrating! Luke 1:5-10 Zechariah and Elizabeth were righteous and blameless according to the Law. Zechariah encountered the angel Gabriel who told him that he would have a child and to name him John. Luke 1:26-33 While Elizabeth was pregnant, Gabriel made a visit to Mary and prophesied that she would give birth to the Messiah. Luke 1:34-36 Although we would prefer a more specific explanation of precisely how Mary became pregnant by divine intervention, the angel just says God's power would overshadow her. Luke 1:37-45 Mary visited Elizabeth who greatly encouraged her right from the start. Elizabeth recognized that Mary was carrying her lord, a term used of many other humans throughout the Bible (Gen 18:12; 33:8; 42:10; Num 11:28; 1 Sam 24:8; 1 Kgs 1:31; 18:7; Ruth 2:13). Luke 1:46-57 This poetic statement of praise was Mary's response to Elizabeth. In it she focused on how God had humbled the powerful and exalted the weak. She would bear the Messiah—the most important human who had ever lived. Matthew 1:18-22 Joseph, Mary's fiancé, first decided to divorce her, but after a nocturnal angelic visit, he came to believe that “the child conceived in her is from the holy spirit.” This child, just like the boy born in Isaiah's time, signified that God had not abandoned His people, instead the child's birth meant “God is with us.”The post Birth of Christ 2: Saving the World through Humans first appeared on Living Hope.
As cannabis prohibition begins to unravel across the world, cannabis use has become more common and normalised. Researchers are assessing the impact of this on vulnerable populations, such as pregnant women. Strikingly, cannabis is among the most commonly used substances during pregnancy, raising serious concerns about its effects on unborn children and the long-term consequences this could have. Prof. Miranda Reed of Auburn University, and colleagues, have assessed how cannabis exposure in the womb can affect brain development and cognitive abilities, such as memory.
Sean Baker's Palme d'Or-winning film “Anora” is generating major Oscar buzz this year and its star, Mikey Madison (Scream, Once Upon a Time... in Hollywood), is already the talk of the town. The story follows a sex worker from Brooklyn who meets and marries the son of a Russian oligarch. But their fairytale romance is threatened after news of their shotgun wedding reaches his parents in Russia. Mikey sits down with Tom to talk about her deep research and preparation for the role, why she feels protective of her character, and how the film has changed her life.
Holy God so often we feel cut off from you and one another. Help us find our way to healing and hope, so that we can become new again. Amen. Strikingly beautiful, Maria had deep dark eyes and long black hair. Superficially she seemed jaded, a kind of rebel. But if you took the time to really know her, she had great intelligence, sensitivity and heart. During my junior year of high school we were close friends. She used to talk about what it felt like getting painfully lost in the shuffle after her parents split up, about her resentful mother being left with almost nothing. In those days divorce was suddenly becoming far more widespread and our society was not prepared. We did not know how to cope with divorce in a humane and grace-filled way. Divorce deeply affects all of us. Perhaps you have gone through a divorce yourself, or maybe it was your parents, your children, a close friend or work colleague. In our society really poor people, the ones who are barely making it, are far more likely to get divorced than wealthy people. Being truly part of the human family means understanding how hard it can be to sustain a relationship and how much pain we can suffer when it breaks down. Many of us also have an experience of new life and joy on the other side of this suffering. What does Jesus offer as we try to understand this feature of the human condition? Many preachers shy away from this complex topic and I worry a little about putting words into Jesus' mouth and a lot about saying something that inadvertently harms you. But I believe that Jesus offers practical and real good news. But like all communication his words need to be interpreted and this requires difficult work. It is worth it because this teaching will lead us to wholeness and new life. The context matters. Jesus has been teaching his disciples about becoming “servants of all.” [1] In fact he says that the world completely misunderstands servanthood. In Imperial Rome but also today we tend to think of servants as lower, lesser, outsiders compelled to work for those who are greater than they are. We easily slip into thinking that the great ones are those who coerce and control others. But Jesus turns this idea on its head. He tells his friends that serving others, especially vulnerable people, is the key to a meaningful life. He says that the greatest one will be servant of all. Some Pharisees come to Jesus. The name Pharisee in Aramaic means “the ones who are set apart.” [2] They care intensely about determining what and who is pure. They are right to fear Jesus because he undermines this whole project. For Jesus there is one human family and no one is impure or left out. The Pharisees ask Jesus, “Is it lawful for a man to divorce his wife?” The narrator calls this question a trap. Whether Jesus says yes or no the Pharisees have a plan to condemn him. Jesus understands that there is no right answer. He also knows what happened after King Herod and his former sister-in-law each divorced their spouses and married each other. John the Baptist criticized their marriage. And this led to his execution by Herod. Rather than trying to set a policy or law on divorce Jesus changes the question. Rather than asking if it is legal to divorce he asks us to consider what God wants for us. During those times there were ethical disagreements concerning divorce. Some believed that the only justification for divorce was sexual infidelity. Others thought that a husband should be able to divorce his wife for pretty much any reason. According to the Book of Deuteronomy a man can write a certificate of divorce if his wife, “does not please him” or, “because he finds something objectionable about her” (Deut. 24:1-4). This biblical passage puts all the power in the hands of the husband. It makes divorce the rule rather than an exception to be employed only after all other courses of action have failed. Most important this law endangers the most vulnerable people in society – women and children who could not own property and who depend for their well-being on the generosity of their husband and father. This actually describes the situation of my friend Maria. Jesus hates just this kind of human suffering. You can almost hear him raise his voice as he says that the reason for a commandment permitting divorce is our “hardness of heart.” But note this. Jesus does not say Moses was wrong. Jesus does not say that the commandment permitting divorce should cease to be a law. Jesus is not forbidding divorce. Instead he uses hyperbole to make a point. In our reading a few weeks ago Jesus said that, “if your eye causes you to sin, tear it out” (Mk. 9:47). Just as this is not a call for us to pluck out our eyes, Jesus describing remarriage as a kind of adultery does not mean that no one should ever get divorced. In every way Jesus says we are children of God and our actions have lasting effects on other children of God many of whom are far more vulnerable than we are. Jesus is the same person who teaches us that the law was made for human beings not human beings for the law. Jesus' point is not to shame people who have already suffered all the effects of a broken relationship. He is not trying to make people stay in a relationship that is abusive or in one that has clearly died. He is not trying to preserve relationships that continue to do damage to the people who are in them. Instead Jesus is moving our attention from what the law permits to God's dream for how our relationships could be. Describing this higher picture of marriage Jesus rejects the Pharisees' approach which only sees the relationship from the perspective of the divorcing husband. In his words here Jesus treats women and men the same (he talks in equal terms about a man and a woman divorcing a spouse). Jesus paints a picture of what love can become. He quotes the book of Genesis and talks about people leaving their families in order to be joined together. So often in my own life I think about the deep and miraculous truth that “the two shall become one flesh.” Adding to this Jesus says that, “what God has joined together, let no one separate.” Let that sink in for a bit. Imagine two beings so united in purpose and affection that they become like one single entity. Imagine God as the source of our deepest relationships and actively at work in helping them to thrive. I understand that marriage is not for everyone. Anyone entering into marriage needs to know that even in the best circumstances it can be hard work. Marriage involves renewing the relationship over and over again. Marriage requires wisdom, communication, perseverance, patience, courage, forgiveness and an openness to what is new and what cannot be controlled. It demands not just a commitment to the other person but to the relationship itself. To be strong a marriage requires a community of support like the one gathered here this morning. Jesus wants us to know that there is more to life than feeling justified by the law and superior to another person. Jesus wants us to strive for goodness, to find the way that we are called to serve. But there are relationships that have become so broken that no matter how hard we try, they cannot be saved. Jesus speaks about this not because we have broken some rule and deserve to be punished, but because it is God's nature to be present to help us when we are suffering. [3] I began by sharing my fear of speaking about divorce with you today. I guess I really did not want to be misunderstood on this point. Jesus does not condemn people for being divorced. Fifty years ago Diane, my mother-in-law and one of the women I most admire, went through a divorce with my father-in-law. Because of this the church she grew up in utterly rejected her. For decades she never felt comfortable in a church and I did not talk to her about it. Some of you might remember that magical midnight Christmas mass ten years ago when she joined us. Delayed by her flight, Diane hesitantly made her way down the center aisle to her pew. In all those years as family we had never worshiped together. In the middle of my sermon, preaching from this pulpit I immediately recognized her. I almost started crying tears of joy because she had come home – loved by God and by you the people who welcomed her. Our reading today ends as Jesus' disciples try to keep children from bothering him. Mark writes that Jesus feels “indignant” about this. He says, “Let the children come to me; do not stop them; for it is to such as these that the kingdom of God belongs.” Mark writes, “And [Jesus] took them up in his arms, laid his hands on them, and blessed them.” This week I keep thinking of my high school friend Maria and Jesus taking her into his arms and blessing her. I imagine Jesus holding Diane with that smile from Christmas on her face and blessing her. And in my mind's eye I see all the people who have suffered the effects of difficult marriages and divorce and he is reaching out to embrace and bless us. [1] Matt Boulton, “One Flesh: Salt's Commentary for the Twentieth Week after Pentecost, SALT, 1 October 2024. https://www.saltproject.org/progressive-christian-blog/2018/10/3/one-flesh-salts-lectionary-commentary-for-twentieth-week-after-pentecost [2] “The appellation “Pharisee” is probably derived from the Aramaic word perishayya which means “the separated one.” Very likely the addresses of Mark's story would not know that. But from previous narrative they have already learned that the Pharisees maintain a pollution system that separates the world into two realms of the clean and the unclean.” Herman Waetjen, A Reordering of Power: A Socio-Political Reading of Mark's Gospel (Philadelphia: Fortress Press, 1989) 165. [3] Canon Edie Weller writes about this in a sermon. She says, “Jesus was a realist. He knew that there are times when we can't reach or maintain the kind of relationship that God might dream for us. There are times and circumstances which lead to broken relationships, from which – as hard as we might work at it – we cannot recover. Jesus speaks about this not because the death of a marriage is more sinful or worse in some way than other experiences of human brokenness. Rather he speaks about this because he cares about us. God's grief in the face of our irreconcilable differences stems not from our having broken the rules or failed a divine test, but from God's response to our experience of such pain. Edie B. Weller, “Sermon for Sunday October 7, 2018 Twentieth Sunday after Pentecost, Year B (Proper 22), St. Peter's Episcopal Church, Seattle, Washington. https://saintmarks.org/staff/the-rev-edie-weller/
Goop and Gay Frogs have a stunning amount in common! Join RadBill and $Mic for an analysis of the two and their racket. Also, this episode is dirty as hell y'all! Here are our sources: https://docs.google.com/document/d/10YxrAmGrqCFTGJpMiv8zvpWrdX10vIRVJY_nTTtiu-w/edit?usp=sharing Here is our subreddit https://www.reddit.com/r/profiteersvsthepeople/ Have a scoop, a pointer or a critique? Email us! profitvspeeps@gmail.com
Retro, a private photo-sharing app, identified significant similarities between its platform and a new feature in Google Photos called "My Week." The feature first appeared in a post on X and encourages users to document and share their week in a format akin to Retro's approach. Ryan Olson, Retro's co-founder and CTO, pointed out the resemblance on X, referencing an Android Authority report that Google Photos plans to launch "My Week" soon. Google confirmed "My Week" as an invite-only experiment designed to help users share memories but did not comment on the similarities. Nathan Sharp, CEO of Retro, acknowledged the resemblances but emphasized Retro's focus on privacy, no ads, and unique features like collaborative journals and photo postcards. Retro is also developing new options like a widget for iOS and direct sharing with "keyholders."Learn more on this news visit us at: https://greyjournal.net/news/ Hosted on Acast. See acast.com/privacy for more information.
In 2017, the tragic events at Saint Rose's Orphanage in Kentucky shocked the community. The entire staff, including house mothers, housekeepers, workers, and security personnel, were discovered deceased and mutilated. Strikingly, all the children were missing. Early in the investigation, authorities found a tape recording that captured some of the harrowing incidents. According to reports, the tape suggested that the children were manipulated into committing the murders by one of the house Mothers. Some speculate that this woman is the notorious exopath known as "Mother-May-I," rumored to have a sinister influence over children and the ability to control them to carry out violent acts. However, the involvement of this individual has not been officially confirmed or denied by law enforcement.Cast:Abrams voiced by Steven ZivicLena voiced by Aubrey AkersBianca voiced by Aubrey Akers Hosted on Acast. See acast.com/privacy for more information.
Welcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: Sycophancy to subterfuge: Investigating reward tampering in large language models, published by Evan Hubinger on June 17, 2024 on The AI Alignment Forum. New Anthropic model organisms research paper led by Carson Denison from the Alignment Stress-Testing Team demonstrating that large language models can generalize zero-shot from simple reward-hacks (sycophancy) to more complex reward tampering (subterfuge). Our results suggest that accidentally incentivizing simple reward-hacks such as sycophancy can have dramatic and very difficult to reverse consequences for how models generalize, up to and including generalization to editing their own reward functions and covering up their tracks when doing so. Abstract: In reinforcement learning, specification gaming occurs when AI systems learn undesired behaviors that are highly rewarded due to misspecified training goals. Specification gaming can range from simple behaviors like sycophancy to sophisticated and pernicious behaviors like reward-tampering, where a model directly modifies its own reward mechanism. However, these more pernicious behaviors may be too complex to be discovered via exploration. In this paper, we study whether Large Language Model (LLM) assistants which find easily discovered forms of specification gaming will generalize to perform rarer and more blatant forms, up to and including reward-tampering. We construct a curriculum of increasingly sophisticated gameable environments and find that training on early-curriculum environments leads to more specification gaming on remaining environments. Strikingly, a small but non-negligible proportion of the time, LLM assistants trained on the full curriculum generalize zero-shot to directly rewriting their own reward function. Retraining an LLM not to game early-curriculum environments mitigates, but does not eliminate, reward-tampering in later environments. Moreover, adding harmlessness training to our gameable environments does not prevent reward-tampering. These results demonstrate that LLMs can generalize from common forms of specification gaming to more pernicious reward tampering and that such behavior may be nontrivial to remove. Twitter thread: New Anthropic research: Investigating Reward Tampering. Could AI models learn to hack their own reward system? In a new paper, we show they can, by generalization from training in simpler settings. Read our blog post here: https://anthropic.com/research/reward-tampering We find that models generalize, without explicit training, from easily-discoverable dishonest strategies like sycophancy to more concerning behaviors like premeditated lying - and even direct modification of their reward function. We designed a curriculum of increasingly complex environments with misspecified reward functions. Early on, AIs discover dishonest strategies like insincere flattery. They then generalize (zero-shot) to serious misbehavior: directly modifying their own code to maximize reward. Does training models to be helpful, honest, and harmless (HHH) mean they don't generalize to hack their own code? Not in our setting. Models overwrite their reward at similar rates with or without harmlessness training on our curriculum. Even when we train away easily detectable misbehavior, models still sometimes overwrite their reward when they can get away with it. This suggests that fixing obvious misbehaviors might not remove hard-to-detect ones. Our work provides empirical evidence that serious misalignment can emerge from seemingly benign reward misspecification. Read the full paper: https://arxiv.org/abs/2406.10162 The Anthropic Alignment Science team is actively hiring research engineers and scientists. We'd love to see your application: https://boards.greenhouse.io/anthropic/jobs/4009165008 Blog post: Perverse incentives are everywhere. Thi...
Recently, President Joe Biden delivered a speech in France to mark 80 years since the world-altering D-Day invasion. Strikingly, elements of his address bore a distinct likeness to a speech previously delivered by former President Ronald Reagan. The likenesses were so strong, it raised eyebrows and sparked conversation about the potential of content duplication from Reagan's much-lauded address. The start of Biden's address harkened back to a similar commencement by President Reagan. Where Reagan set the scene saying, 'At dawn on the morning of the 6th of June, 1944', Biden paralleled with an uncannily similar introduction. His recounting of the arrival of two hundred and twenty-five American Rangers echoed Reagan's vivid description of the same historical moment. Both speeches memorialized the audacious courage of the Rangers. Biden laid out their heroic climb: 'They launched their ladders, their ropes and grappling hooks, and they began to climb', eerily reminiscent of Reagan's oration, 'They shot rope ladders over the face of these cliffs and began to pull themselves up.' The parallels, far from random or coincidental, nudged the similarity towards plagiarism. Biden's painting of the Rangers' valorous response when faced with Nazi resistance aligned almost identically with Reagan's. According to Biden, 'When the Nazis cut their ladders, the Rangers used the ropes, and the Nazis cut the ropes. The Rangers used their hands.' Reagan's words had previously encapsulated this same spirit: 'When one Ranger fell, another would take his place. When one rope was cut, a Ranger would grab another and begin his climb again.'See omnystudio.com/listener for privacy information.
Arjen F. Bakker's book The Secret of Time: Reconfiguring Wisdom in the Dead Sea Scrolls (Brill, 2023) contributes to the rethinking of the Dead Sea Scrolls as an essential and integral part of Judaism in the Greco-Roman period. The Qumran manuscripts attest to the reconfiguration of Jewish wisdom concepts in this period. Strikingly, reflection on time as the organizing principle behind all of reality is formative for these emerging concepts, which are expressed by the enigmatic phrase rāz nihyeh. The secret of time invites us to venture beyond existing categorizations and explore a rich conceptual framework that is manifested across a wide range of texts, beyond generic categories, and overcoming the sectarian divide. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network
Arjen F. Bakker's book The Secret of Time: Reconfiguring Wisdom in the Dead Sea Scrolls (Brill, 2023) contributes to the rethinking of the Dead Sea Scrolls as an essential and integral part of Judaism in the Greco-Roman period. The Qumran manuscripts attest to the reconfiguration of Jewish wisdom concepts in this period. Strikingly, reflection on time as the organizing principle behind all of reality is formative for these emerging concepts, which are expressed by the enigmatic phrase rāz nihyeh. The secret of time invites us to venture beyond existing categorizations and explore a rich conceptual framework that is manifested across a wide range of texts, beyond generic categories, and overcoming the sectarian divide. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/history
Arjen F. Bakker's book The Secret of Time: Reconfiguring Wisdom in the Dead Sea Scrolls (Brill, 2023) contributes to the rethinking of the Dead Sea Scrolls as an essential and integral part of Judaism in the Greco-Roman period. The Qumran manuscripts attest to the reconfiguration of Jewish wisdom concepts in this period. Strikingly, reflection on time as the organizing principle behind all of reality is formative for these emerging concepts, which are expressed by the enigmatic phrase rāz nihyeh. The secret of time invites us to venture beyond existing categorizations and explore a rich conceptual framework that is manifested across a wide range of texts, beyond generic categories, and overcoming the sectarian divide. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/jewish-studies
Arjen F. Bakker's book The Secret of Time: Reconfiguring Wisdom in the Dead Sea Scrolls (Brill, 2023) contributes to the rethinking of the Dead Sea Scrolls as an essential and integral part of Judaism in the Greco-Roman period. The Qumran manuscripts attest to the reconfiguration of Jewish wisdom concepts in this period. Strikingly, reflection on time as the organizing principle behind all of reality is formative for these emerging concepts, which are expressed by the enigmatic phrase rāz nihyeh. The secret of time invites us to venture beyond existing categorizations and explore a rich conceptual framework that is manifested across a wide range of texts, beyond generic categories, and overcoming the sectarian divide. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/middle-eastern-studies
Arjen F. Bakker's book The Secret of Time: Reconfiguring Wisdom in the Dead Sea Scrolls (Brill, 2023) contributes to the rethinking of the Dead Sea Scrolls as an essential and integral part of Judaism in the Greco-Roman period. The Qumran manuscripts attest to the reconfiguration of Jewish wisdom concepts in this period. Strikingly, reflection on time as the organizing principle behind all of reality is formative for these emerging concepts, which are expressed by the enigmatic phrase rāz nihyeh. The secret of time invites us to venture beyond existing categorizations and explore a rich conceptual framework that is manifested across a wide range of texts, beyond generic categories, and overcoming the sectarian divide. Learn more about your ad choices. Visit megaphone.fm/adchoices
Arjen F. Bakker's book The Secret of Time: Reconfiguring Wisdom in the Dead Sea Scrolls (Brill, 2023) contributes to the rethinking of the Dead Sea Scrolls as an essential and integral part of Judaism in the Greco-Roman period. The Qumran manuscripts attest to the reconfiguration of Jewish wisdom concepts in this period. Strikingly, reflection on time as the organizing principle behind all of reality is formative for these emerging concepts, which are expressed by the enigmatic phrase rāz nihyeh. The secret of time invites us to venture beyond existing categorizations and explore a rich conceptual framework that is manifested across a wide range of texts, beyond generic categories, and overcoming the sectarian divide. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/religion
In the culmination of a high-profile legal saga, lawyers of former President Donald Trump are preparing to deliver their final blows in the hush-money trial against Trump's former attorney, Michael Cohen, as reported by The Guardian. The criminal case, which has been the center of much media attention, implicates Trump in attempts to stifle negative reports alleging sexual encounters with adult film star Stormy Daniels and others--a move which has further stirred the political waters surrounding the ex-president. Trump's defense looks set to deliver a blistering assault on the credibility of Cohen, whose actions have added to the cloud hanging over Trump's presidency and his subsequent post-presidential career. Cohen pled guilty in 2018 to campaign finance violations and other crimes related to the payment of $130,000 to Stormy Daniels just before the 2016 election. Trump's alleged involvement in the payment is at the heart of the ongoing hush-money trial.This high-stakes courtroom drama has raised important legal, political, and moral questions. Strikingly, the case underscores an often thorny issue in American politics and democracy: the power and influence of money and its potential misuse. Moreover, the case highlights the increasingly fraught relationship between politics and the media. It underscores the extent to which some political individuals may go to control or suppress unfavorable narratives from seeing the light of day. The allegation that a then-presidential candidate influenced the media landscape to suppress negative stories is as alarming as it is newsworthy.The outcome of this trial could have profound implications. A conviction could significantly damage Trump's reputation and future political prospects. Conversely, an acquittal could bolster Trump's narrative of being subjected to a "witch hunt," a claim he has often made in the face of the numerous probes and allegations surrounding him. As the trial unfolds, the world awaits the final verdict, which continues to dangle above the political landscape like a sword of Damocles. Regardless of the outcome, this case has already marked a significant chapter in American political history, reminding us yet again of the contentious and often unpredictable relationship between political power, personal conduct, and the law.
Plus, Butker commencement speech spotlights religious war on women's freedom, even Taylor Swift
Under the Radar: The Oxford School Shooter Report - A 'Stop the Killing' Episode Breakdown Part Two Part Two: Unraveling the Oxford High Shooter's Background In this second part of the deep dive into the Oxford High School shooting, the hosts discuss the shooter's academic performance and demeanor leading up to the tragic event, where he killed four people and pleaded guilty to terrorism. Insights from a comprehensive report on the shooter, who was a 10th grader at the time, reveal interviews with teachers and classmates that paint a picture of him as quiet, engaged in some classes but struggling academically, especially post the COVID-19 lockdown. Distinctly, he showed a significant academic decline starting early November, coinciding with his complete halt in submitting assignments for several classes. Strikingly, journal entries from the shooter express his frustration, depression, and the desire to be noticed by adults as potentially dangerous. Despite the shooter's troubling signs, including an interest in guns and explicit mentions of shooting plans in his journal, the show discusses systemic failures at multiple levels that failed to preemptively address the shooter's deteriorating mental health and intent. The conversation also explores the complicated issue of privacy and parental oversight in the context of recognizing warning signs in children. 00:00 Introduction to Part Two: Unveiling the Oxford School Shooter 01:45 Diving into the Shooter's Academic and Social Background 01:58 Analyzing the Shooter's Behavior and Interactions 16:29 The Significance of the Shooter's Journal Entries 18:54 Parental Guidance and the Importance of Monitoring 28:42 Concluding Thoughts on Preventative Measures and Reflection WANT THE VIDEOS HEAD TO YOUTUBE @sarahferrismedia And if you are wanting AD FREE | EARLY ACCESS | BONUS CONTENT HIT THE BANNER ON APPLE PODCASTS TO SUBSCRIBE OR SUPPORT US: Patreon.com/stopthekilling Send us your Listener Questions for our Tuesday episodes Message us on instagram : @conmunitypodcast @stopthekillingstories And for all things Katherine Schweit including where you can purchase her book STOP THE KILLING: How to end the mass shooting crisis head to: www.katherineschweit.com SUPPORTING OUR SPONSORS, SUPPORTS THE PODCAST CRIMECON UK TICKETS HERE CRIMECON US TICKETS HERE DON'T forget to use DISCOUNT CODE “FERRIS” RESOURCES Stop the Bleed training FBI RUN, HIDE, FIGHT This is a Sarah Ferris Media on the Killer Podcasts Network Check out more Sarah Ferris Media productions: CONNING THE CON KLOOGHLESS - THE LONG CON GUILTY GREENIE THE BRAVERY ACADEMY Learn more about your ad choices. Visit megaphone.fm/adchoices
Guest post by Kieran McCorry, National Technology Officer, Microsoft Ireland In the fast-evolving cyber landscape in Ireland, organisations are susceptible and vulnerable to attack, as highlighted by Microsoft Ireland's 'Cybersecurity Trends in Ireland' report. This exploration of the experiences of c-suite executives operating in Ireland delves into cybersecurity trends, shedding light on prevalent challenges, emerging technologies, and the imperative need for proactive measures. Cybersecurity vulnerabilities persist across Irish industries, exacerbated by the absence of comprehensive defence strategies. While there's a good adoption of cybersecurity training, the true resilience demanded by the evolving threat landscape necessitates ongoing investments in technological solutions. Our report reveals that 46% of respondents have faced cyber incidents in the last three years, with 30% experiencing data breaches. Strikingly, only 14% reported incidents to regulatory bodies. Despite these challenges, 74% of organisations haven't reduced their cybersecurity spend and 57% conduct regular cybersecurity training. However, a significant gap exists in strategic processes with just 44% performing risk assessments and 38% employing a multi-layered defence strategy. The study also points to a potential complacency with 26% of organisations indicating a lack of IT security infrastructure investment planned for the coming year. Artificial Intelligence as a Cybersecurity Enabler While the adoption of Artificial Intelligence (AI) technologies to support defensive strategies is slow - just 14% of executives say they are using AI as part of their cybersecurity strategy, while a further 30% say they are unsure if they are in fact using AI technologies - 'Cybersecurity Trends in Ireland' underscores the rising significance of AI in cybersecurity. AI technologies offer a potent defence against cyber threats by swiftly analysing vast data sets. Notably, the successful use of AI in Ukraine against cyberattacks sets a precedent for the role of innovation in cybersecurity. However, the integration of AI comes with its own set of challenges. Security teams grapple with managing disparate tools and a scarcity of skilled talent. Microsoft's recent strides in unifying incident experiences through Microsoft Sentinel and Microsoft Defender XDR mark a significant leap toward cohesive and efficient cybersecurity strategies. Meanwhile, from 1st of April, Microsoft Copilot for Security will be available in Ireland. The industry's first generative AI solution will help security and IT professionals catch what others miss, move faster, and strengthen team expertise. Copilot is informed by large-scale data and threat intelligence, including more than 78 trillion security signals processed by Microsoft each day, and coupled with Large Language Models to deliver tailored insights and guide next steps. With Copilot, users can protect their environments at the speed and scale of AI and transform their security operations. Regulation and Compliance A concerning revelation from our Cybersecurity Trends in Ireland study is the lack of awareness among Irish executives regarding upcoming legislation; specifically, the Network and Information Security 2 Directive (NIS2). Scheduled for implementation in October 2024, NIS2 will impact 18 sectors and over 180,000 companies across the EU. Despite its potential to strengthen cybersecurity postures, more than 70% of leaders are either unaware or unprepared for compliance. Of those who are aware of NIS2, 20% feel they are currently compliant with the legislation and 20% believe they are not compliant. 60% of all respondents are unsure if they are or not. Positively, 31% of organisations are planning to invest in their strategy to achieve compliance with NIS2 and 29% have a roadmap in place to achieve this. That said, this lack of awareness extends to the majority being unsure about their organisations having investment or a roa...
Strikingly similar features, same positions, same styles and both number 37. Welcome Josh Draper-Johnson. Time to Restump Podcast the Kangas clash at 10.45am Saturday morning, sponsored by Cornflakes! The horrendous loss to North Melbourne in round two in 2023 was one to forget. However, we should remember philosopher George Santayana's famous quote, “Those who cannot remember the past are condemned to repeat it.” So, while we're warm favourites, we shouldn't take the Kangas lightly. In fact, we're not a club that is entitled to take any opponent lightly.Having said all that, when you look at the lists on paper and the proposed match ups… it is difficult not being over-confident. Even with our severe injury toll, you kind of think a repeat of last week's pressure against the Lions will get the job done against the Kangas.It is great to see our unofficial father-son prospect, Josh Draper, get a gig. In the preseason you'd swear he was Michael Johnson reborn. Brandon Walker is a very welcomed return and the insertion of some experience in the form of Jaegar O'Meara surely won't go astray. Admittedly through necessity and no real fault of his own, Matty Tabs gets another opportunity. With Paddy Voss waiting on the sidelines, Tab's surely knows he has to make every post a winner.The Kangas were decent in patches against the highly talented Giants last week and they welcome back two pretty handy types. Jy Simpkin goes back into their midfield after that horrific concussion and they'll be keen to see the steady and reliable Luke McDonald assist their somewhat undermanned defence.Plenty of other goings on so given our game starts at 10.45am Saturday morning we better get on with it! There aren't too many hours between now and game time but if you're looking to waste one, we'll kill it for you. Support the show
Our women and girls are being taken from us in an alarming way. As of 2016, the National Crime Information Center has reported 5,712 cases of missing American Indian and Alaska Native women and girls. Strikingly, the U.S Department of Justice missing persons database has only reported 116 cases. The majority of these murders are committed by non-Native people on Native-owned land. The lack of communication combined with jurisdictional issues between state, local, federal, and tribal law enforcement, make it nearly impossible to begin the investigative process. Today we go over another MMIW case that is dear to our hearts, Kaysera Stops Pretty Places. On August 24, 2019, Kaysera Stops Pretty Places vanished, not so far away from the Crow Reservation. Five days later, on August 29, 2019, her body was discovered in Hardin, Montana in a neighborhood where she was last seen alive. It wasn't until September 11—nearly two weeks later—that law enforcement finally disclosed the tragic truth to Kaysera's family."Welcome to Nightmares of the Americas Indigenous tales. https://www.niwrc.org/policy-center/mmiw Merch store- https://indigenoustales.threadless.com/Email us at info@behillnetwork.com Also check out our Instagram -https://www.instagram.com/indigenous_tales/And our TikTok -https://www.tiktok.com/@indigenous_talesAmanda Bland Dallas area Bakeryinstagram - https://www.instagram.com/cupidsweetsbakes/Cupid Sweets- https://www.facebook.com/cupidsweets
200. Strikingly | David Chen dropped out from the University of Chicago to start Strikingly along with his two co founders, Teng Bao and Dafeng Guo. They moved to Silicon Valley with $100 in their pocket and were accepted into Y Combinator after eating ramen noodle in their 1-bedroom apartment for 5 months. Strikingly is a Y Combinator-backed startup that allows anyone to create a gorgeous, mobile optimized website in minutes, without any coding or design work. It has raised $1.5MM seed funding from top Silicon Valley investors. *** For Show Notes, Key Points, Contact Info, Resources Mentioned, & the Fabulous 4 Questions on this episode visit our website: David Chen Interview. *** If you have land in North Carolina, then check out: https://bubba-land.com/north-carolina/
The blog post Ecologists and other environmentally aware people often talk about the goal of "Zero Waste." But, of course, that's an outstanding goal for business as well.Reducing waste is at the heart of the Lean business methodology. The purpose of Lean is to spend more of your time creating value for customers by reducing or eliminating everything that does not produce value (AKA the waste). Value can take the form of finished goods, services, or information. To make it easier to identify waste in business processes, Lean practitioners target eight specific types of waste.Although the Lean approach originated in manufacturing, it is used in almost every sector. Strikingly the eight wastes are common across industries, including software development, construction, healthcare, and education. Although it is not as apparent as it may be on a factory floor, the set of tasks and activities performed in any sector creates a production process that ultimately provides value to a customer.While some of the wastes are self-explanatory, others are more difficult to recognize. This post aims to help by giving a few examples of each type of waste in various businesses. Hopefully, they will help you think about how waste may be occurring in your operations and how to begin designing processes that minimize it. Of course, the people who are most likely to find and correct waste are the process operators, so it is a good idea to share these examples with them and provide a way for each employee to submit opportunities for improvement.
Episode 201 contains the Digital Marketing News and Updates from the week of Feb 26 - Mar 1, 2024.1. ‘How Google Search Crawls Pages' - In a comprehensive video from, Google engineer Gary Illyes sheds light on how Google's search engine discovers and fetches web pages through a process known as crawling. Crawling is the first step in making a webpage searchable. Google uses automated programs, known as crawlers, to find new or updated pages. The cornerstone of this process is URL discovery, where Google identifies new pages by following links from known pages. This method highlights the importance of having a well-structured website with effective internal linking, ensuring that Google can discover and index new content efficiently.A key tool in enhancing your website's discoverability is the use of sitemaps. These are XML files that list your site's URLs along with additional metadata. While not mandatory, sitemaps are highly recommended as they significantly aid Google and other search engines in finding your content. For business owners, this means working with your website provider or developer to ensure your site automatically generates sitemap files, saving you time and reducing the risk of errors.Googlebot, Google's main crawler, uses algorithms to decide which sites to crawl, how often, and how many pages to fetch. This process is delicately balanced to avoid overloading your website, with the speed of crawling adjusted based on your site's response times, content quality, and server health. It's crucial for businesses to maintain a responsive and high-quality website to facilitate efficient crawling.Moreover, Googlebot only indexes publicly accessible URLs, emphasizing the need for businesses to ensure their most important content is not hidden behind login pages. The crawling process concludes with downloading and rendering the pages, allowing Google to see and index dynamic content loaded via JavaScript.2. Is Google Happy with 301+410 Responses? - In a recent discussion on Reddit, a user expressed concerns about their site's "crawl budget" being impacted by a combination of 301 redirects and 410 error responses. This situation involved redirecting non-secure, outdated URLs to their secure counterparts, only to serve a 410 error indicating the page is permanently removed. The user wondered if this approach was hindering Googlebot's efficiency and contributing to crawl budget issues.Google's John Mueller provided clarity, stating that using a mix of 301 redirects (which guide users from HTTP to HTTPS versions of a site) followed by 410 errors is acceptable. Mueller emphasized that crawl budget concerns primarily affect very large sites, as detailed in Google's documentation. If a smaller site experiences crawl issues, it likely stems from Google's assessment of the site's value rather than technical problems. This suggests the need for content evaluation to enhance its appeal to Googlebot.Mueller's insights reveal a critical aspect of SEO; the creation of valuable content. He criticizes common SEO strategies that replicate existing content, which fails to add value or originality. This approach, likened to producing more "Zeros" rather than unique "Ones," implies that merely duplicating what's already available does not improve a site's worth in Google's eyes.For business owners, this discussion underlines the importance of focusing on original, high-quality content over technical SEO manipulations. While ensuring your site is technically sound is necessary, the real competitive edge lies in offering something unique and valuable to your audience. This not only aids in standing out in search results but also aligns with Google's preference for indexing content that provides new information or perspectives.In summary, while understanding the technicalities of SEO, such as crawl budgets and redirects, is important, the emphasis should be on content quality. Businesses should strive to create original content that answers unmet needs or provides fresh insights. This approach not only helps with better indexing by Google but also engages your audience more effectively, driving organic traffic and contributing to your site's long-term success.3. UTM Parameters & SEO - Google's John Mueller emphasized that disallowing URLs with UTM parameters does not significantly enhance a website's search performance. Instead, he advocates for maintaining clean and consistent internal URLs to ensure optimal site hygiene and efficiency in tracking.Mueller's advice is straightforward: focus on improving the site's structure to minimize the need for Google to crawl irrelevant URLs. This involves refining internal linking strategies, employing rel-canonical tags judiciously, and ensuring consistency in URLs across feeds. The goal is to streamline site management and make it easier to track user interactions and traffic sources without compromising on SEO performance.A notable point Mueller makes is regarding the handling of external links with UTM parameters. He advises against blocking these through robots.txt, suggesting that rel-canonical tags will effectively manage these over time, aligning external links with the site's canonical URL structure. This approach not only simplifies the cleanup of random parameter URLs but also reinforces the importance of direct management at the source. For instance, if a site generates random parameter URLs internally or through feed submissions, the priority should be to address these issues directly rather than relying on robots.txt to block them.In summary, Mueller's guidance underscores the importance of website hygiene and the strategic use of SEO tools like rel-canonical tags to manage URL parameters effectively. His stance is clear: maintaining a clean website is crucial, but blocking external URLs with random parameters is not recommended. This advice aligns with Mueller's consistent approach to SEO best practices, emphasizing the need for site owners to focus on foundational site improvements and efficient management of URL parameters for better search visibility and tracking.4. Transition Required for Google Business Profile Websites - Google has announced that starting in March 2024, websites created through Google Business Profiles (GBP) will be deactivated, with an automatic redirect to the businesses' Google Business Profile in place until June 10, 2024. This move requires immediate attention from GBP website owners to ensure continuity in their online operations.For businesses unsure if their website is hosted through Google Business Profiles, a simple search on Google for their business name and accessing the edit function of their Google Business Profile will reveal if their website is a GBP creation. It's indicated by a message stating, “You have a website created with Google.” For those without a GBP website, the option to link an external site will be available.In response to this change, Google has recommended several alternative website builders for affected businesses. Among the suggested platforms are Wix, Squarespace, GoDaddy, Google Sites, Shopify (specifically for e-commerce), Durable, Weebly, Strikingly, and WordPress. Each offers unique features, with WordPress notable for its free website builder incorporating generative AI capabilities. However, users should be aware ...
Today, after a mess of scheduling issues I FINALLY sat down with Tisha Marie Reichle-Aguilera about her debut novel BREAKING PATTERN. In which she goes right back to her roots in the rodeo and horse world but through a YA lens. Follow Tisha Follow On The Shelf Map of Indie Bookstores (now with Libromobile) Get BREAKING PATTERN Libromobile (CA) Quail Ridge Books (NC) Odyssey Books (MA)
The lastest episode from the Pearl Church.
As larger portions of Gen-Z reach legal drinking age, their impact on the alcohol industry is becoming more pronounced and the segment's preferences have come into full view. What's become increasingly clear is that how this demographic interacts with alcohol is dramatically different from each generation that's come before it. Strikingly, Gen-Z is more inclined to imbibe on-premise than any other age bracket in the current market. So as this demographic brings its shifting consumption patterns into bars, restaurants, and venues, in this Essential Talk, Charlie Mitchell, Research & Insights Director at Nielsen IQ Global, is taking a look at how brands can adapt to capture Gen-Z's attention on-premise. Key topics mentioned: Identifying Gen-Z: Mitchell explores the core values of Gen-Z to give brands and bars a sense of how to target this consumer group. "If you activate well, you can build relationships for life." The importance of digital marketing: Gen-Z is highly inclined to explore new categories. One of the biggest contributing factors to how they establish new associations with brands is through social media. Mitchell shares some strategies for engaging Gen-Z digitally before they even arrive on-premise. Occasion based drinking: Mitchell makes the case for why the on-premise's allure to Gen-Z is rooted in their value for experiences. He dives into the type of experiences Gen-Z is after and how they can drive engagement from this demographic. In this episode you'll hear from:Charlie Mitchell, Research & Insights Director, Nielsen IQ Global Mentioned in this episode:NielsenIQ Learn More About Park StreetSign up for our Daily Industry Newsletter.Sign Up for our Monthly Newsletter.Check out Park Street's Guide to Getting Started in the U.S. MarketFollow us for more industry insights onLinkedIn FacebookTwitterInstagram
Connor reveals data that says the Chiefs superstar is in a class all his own. We're pretty sure you knew that, but the level of competition for #15 has been STRIKINGLY better than that of Tom Brady.
Real News Now Podcast: 25 Republican Governors Unite To Support Texas In Its Fight To Secure The Border Twenty-five Republican leaders across our great nation came together, unified, to voice their support for the Lone Star state, Texas, in its mission for enhanced border security. Tensions have stirred in recent times as the new administration actively impends Texas' determined pursuit for border fortification around its Mexican boundary. This has consequently been perceived as an open invitation to unchecked illegal immigration. The current President's Administration has left us wide open, susceptible to an intense influx of illegal immigration unprecedented in our nation's vibrant history. Broadly speaking, instead of prioritizing laws established by our forefathers and taking measures to secure our borders, the political leadership now lodged in the White House has instead chosen to question and challenge Texas for its commitment to protect its own citizens. This contention is against escalating waves of illegal immigration, the fervor of deadly narcotics such as fentanyl, and an underlying concern of invisible threats infiltrating our homeland. The Administration's actions betray the eyes of strengthened vigilance that never rest, always ready to defend our freedom. Twenty-five leaders, a representation of genuine American spirit and resilience, boldly stand in solidarity with the Governor of Texas, Greg Abbott. Together, they support his state's resilience and adaptability in employing every practical tool and method at their disposal, even bolstering security with a razor wire fence, to secure the sovereign borderland Texas cherishes. This critical step is, in part, a countermeasure to the refusal of the current Administration to reinforce immigration laws fundamentally enshrined in our nation. This refusal has led to a sweeping and near-unilateral allowance for migrants who entered our nation unlawfully to roam free, leaving the burden to the states and their leaders unceremoniously. These prominent leaders argue coherently that our U.S. Constitution adequately dictates that each state reserves the right to defend itself. A role none more important now when the present administration seemingly forgoes its constitutional responsibilities to the states. Hence, substituting and amplifying the role of Texas with every possible legal means towards sovereignty becomes the noble and justifiable course of action. Strikingly, they opine that our nation's sovereignty should similarly be fortified using every legally permissible mechanism. The distinguished collection of voices bear in their signatures the weight of resolve and unity. An impressive roster includes Governor Ron DeSantis of Florida, Governor Brian Kemp of Georgia, Oklahoma's Governor Kevin Stitt, Montana's Governor Greg Gianforte, Nevada's Governor Joe Lombardo, and Iowa's Governor Kim Reynolds, among others. Continuing this notable list of patriots and leaders, the Granite State's Governor Chris Sununu, Governor Kay Ivey from Alabama, Governor Mike Dunleavy of Alaska, Governor Sarah Sanders of Arkansas, and Governor Brad Little representing Idaho all added their support for this cause. Further backing came from Governor Eric Holcomb of Indiana, Louisiana's Governor Jeff Landry, Governor Tate Reeves of Mississippi, Missouri's Governor Mike Parson, and Governor Jim Pillen from Nebraska. They all join this concerted effort towards border security. Governor Doug Burgum of North Dakota, the Buckeye State's Governor Mike DeWine, Governor Henry McMaster of South Carolina, and South Dakota's Governor Kristi Noem have also thrown their support behind Texas, further consolidating the call for sovereign protection. Adding to this meaningful accord, Governor Bill Lee from Tennessee, Utah's Governor Spencer Cox, Virginia's fresh leadership in the form of Governor Glenn Youngkin, West Virginia's Governor Jim Justice, and Wyoming's Governor Mark Gordon round off this resolute group of leaders standing alongside Texas. Indicatively, there wasn't unanimous consensus among all Republican governors. Significantly committing to the sidelines, Vermont Governor Phil Scott represents the singular Republican governor across the nation who abstained from adding his name to this substantial statement—a notable lack of unity. Source: https://www.realnewsnow.com/25-us-leaders-rally-behind-texas-for-border-security/ Follow Real News Now on Social Media Facebook: https://www.facebook.com/RealNewsNowApp/ X Twitter: https://twitter.com/realnewsapp Instagram: https://www.instagram.com/realnews/ TikTok: https://www.tiktok.com/@realnewsnowapp Threads: https://www.threads.net/@realnews/ Truth Social: https://truthsocial.com/@RealNews YouTube:https://www.youtube.com/@realnewsnowapp Video: https://youtu.be/pL2jaOml2AQ See omnystudio.com/listener for privacy information.
Strikingly beautiful gay people , Gracin Nicole Gracin, Georgia Bridgers and Kaydence De Mere talk about relayshunships! What's our current status? Single ready to mingle? Situationship? Married with children? What are we looking for, what have we looked for in the past, what's our ideal set up, taken, single, halfway taken, halfway single, ETC. How have we been traumatized? How that's inevitably negatively affected us in the way that we date for the rest of our lives hehehehe. We spill all the tea on the latest going on in our sexy little twink little gay little dating lives. So tune in if you're nosey and gay (hopefully all of you)
Links: Go to episode page (with study links) Subscribe to Premium Sigma's recommended resources Get our weekly email newsletter About This Episode: Insufficient energy availability can significantly disrupt normal hormonal, metabolic, and physiological processes, prompting the body to initiate a coordinated response aimed at conserving energy. While commonly viewed as beneficial for weight loss and managing cardiometabolic conditions in the current obesity epidemic, chronic energy deficiency in the context of modern sports and exercise nutrition is linked to adverse health outcomes and diminished athletic performance. Nevertheless, the evidence regarding the negative impact of energy deficit on physical capacity and sports performance is not entirely clear. Although severe energy deficiency can impair physical capacity, it's noteworthy that humans can enhance aerobic fitness and strength even in the presence of significant energy deficits. Strikingly, many elite athletes compete at the highest levels despite displaying evident signs of energy deficiency. This raises intriguing questions about how the human body adapts to energy deficits, challenging conventional views on the relationship between energy availability and athletic prowess. To discuss some potential reasons for this ability to maintain peak physical performance while suppressing energetically demanding physiological traits, researcher Dr. Jose Areta of LJMU is on the podcast to discuss his work in this area. About The Guest: Dr. José Areta currently works as a lecturer in Sports Nutrition and Metabolism at the School of Sport and Exercise Sciences at LJMU. José's primary interest is in the area of training-nutrient interactions in humans. In other words, he investigates how to manipulate ingestion of carbohydrates, fat and protein around training to optimise physical performance and health. The outputs of his research have not only expanded the knowledge of the field but had significant impact and influence on determining current dietary recommendations and practices world-wide. His work has provided novel insights in relation to the amount, timing, quantity and distribution of carbohydrates, fat and protein and dietary supplements around training. Over the last few years José has been developing his research in the area of the endocrinological, metabolic and physiological effects of energy restriction, in which he is currently growing his research team and capability.
On a recent day, renowned television personality, formerly of Fox News, Tucker Carlson, went public with his probable stand against any 2024 presidential aspirations Donald Trump might hold, especially if he considers Nikki Haley, the former UN ambassador and GOP contestant, as his Vice Presidential candidate. Strikingly, Mr. Carlson affirmed not just his potential non-support, but adamantly expressed that he would promote others to resist such a pairing. These comments surfaced as the first public response from Carlson to the buzz surrounding Trump's possible consideration of him as a running mate for the upcoming 2024 elections. Adding an unexpected twist, Melania Trump, the former First Lady, seemingly holds a different viewpoint. Reports suggest that she leans towards Carlson as a suitable candidate to join in on Trump's quest for a comeback bid, postulating that she might be more inclined to campaign actively if such an arrangement turns to be the case. Yet, certain circles surrounding the former President seem to hold contrasting beliefs. They doubt the feasibility of Tucker Carlson's nomination, firmly believing that Trump is unlikely to opt for a running mate who could potentially overshadow him. Indeed, the interplay of egos could make such a high-stakes collaboration improbable. In a discussion with SiriusXM and prominent journalist Megyn Kelly, Carlson shared the sentiment that stepping into the political fray would be nothing short of colossal for him. He said, 'The idea itself is virtually unfathomable. I have not led a lifestyle that inherently orients one towards politics. And the contemplation of serving in the political realm with anyone feels extraordinarily complex to process.' See omnystudio.com/listener for privacy information.
In this week's captivating episode of Hidden Files, delve into the intriguing case of Venkat, who found a match on a dating website. Their planned rendezvous at a restaurant took an unexpected turn when the mysterious girl failed to appear. Strikingly, Venkat's flatmate Ashwin faced a similar incident on the very same date. Is this an uncanny coincidence, or could there be an underlying cybercrime at play? Find out in this week's episode of Hidden Files.See omnystudio.com/listener for privacy information.
I'm excited to bring you the latest in a multi-part series sponsored by Contrast & Co., an award-winning brand strategy and communications agency determined to build the most strikingly different brand experiences anywhere. Today we're going to talk about creating a strikingly different brand, why it is so important, as well as the cost of inauthenticity in branding. To help me discuss this topic, I'd like to welcome Dharma Pachner, Founder & Chief Creative Officer at Contrast & Co. RESOURCES PartnerHero: to waive set up fees, go to https://partnerhero.com/agile and mention “The Agile Brand” during onboarding! The Agile Brand podcast website: https://www.gregkihlstrom.com/theagilebrandpodcast Sign up for The Agile Brand newsletter here: https://www.gregkihlstrom.com Get the latest news and updates on LinkedIn here: https://www.linkedin.com/company/the-agile-brand/ For consulting on marketing technology, customer experience, and more visit GK5A: https://www.gk5a.com Check out The Agile Brand Guide website with articles, insights, and Martechipedia, the wiki for marketing technology: https://www.agilebrandguide.com The Agile Brand podcast is brought to you by TEKsystems. Learn more here: https://www.teksystems.com/versionnextnow The Agile Brand is produced by Missing Link—a Latina-owned strategy-driven, creatively fueled production co-op. From ideation to creation, they craft human connections through intelligent, engaging and informative content. https://www.missinglink.company
Welcome to Episode 191 of TFRS, where we shift the spotlight from amassing wealth to gaining time and choices in life. Research has shown that once our income meets our needs and allows for savings, accumulating more money doesn't significantly elevate our happiness. Strikingly, those with substantial wealth often feel worse off, comparing themselves to those with more. A fascinating study delved into the lives of multimillionaires, revealing that most believed an additional $5 million would bring them greater happiness. But studies, including one from Harvard analyzing 100,000 individuals, highlight that prioritizing time over money leads to more fulfilling social relationships, satisfying careers, and overall higher rates of contentment. This episode uncovers the four key benefits of adopting a time-centric approach. It's evident that those feeling time-poor exhibit lower happiness levels, higher stress, anxiety, and reduced joy. By emphasizing time, people enhance social connections, build healthier relationships, and experience increased job satisfaction, all while achieving similar or greater income. We delve into practical strategies to reorient your priorities towards time. Understanding your core values and the real cost of spending money (which is time you've worked hard to earn) is a crucial starting point. Reflecting on your “why” and whether material possessions align with a more fulfilling life is another pivotal step. Finally, a poignant reminder that time is our most precious asset. We're all destined to reach the end of our journey, and when reflecting on life's moments, it's the quality time spent with loved ones, pursuing happiness, or contributing to the world that truly matters. The podcast episode concludes by highlighting the immeasurable value of time over money in crafting a more enriching and satisfying life.
Dr Lisa Cameron was the SNP MP for East Kilbride, Strathaven and Lesmahagow from 2015 until a week ago when she decided to join the Conservative Party. She has described the move as equivalent to leaving an abusive marriage. In her first radio interview since her defection, she joins Emma Barnett to discuss what led to her making this decision. Listeners who have been through IVF treatment will be familiar the extra – and often very expensive – add-on services that many clinics recommend. The Human Fertilisation and Embryology Authority (HFEA), the fertility regulator, has now launched a ratings system to let patients see which add-ons are backed-up by evidence. Strikingly, not one of them has been given the highest "green" rating. Professor Tim Child chairs the HFEA's Scientific and Clinical Advances Advisory Committee. Jessica Hepburn spent over £70,000 on unsuccessful fertility procedures and now campaigns about the fertility industry. They joined Emma to discuss. Three Little Birds is a new ITV series written by Lenny Henry which follows three women who emigrate from Jamaica to England in the 1950s - post-Windrush. The series is inspired by the stories of Lenny Henry's family who, although had positive experiences of being helped as new arrivals, also shared accounts of physical and racial abuse when they reached the UK. Saffron Coomber who plays ‘Chantrelle' and director Yero Timi Biu talk about the show. Julia Fox is an actor, artist and fashion icon, as famous for her breakout role in the film Uncut Gems as she is for her spectacular avant-garde fashion choices. She became tabloid fodder after a brief relationship with Kanye West. Her memoir Down the Drain describes a troubled childhood of sex, drugs and abusive relationships in Italy and New York. She tells Emma how her high-fashion image allows her to escape the male gaze. Presenter: Emma Barnett Producer: Lisa Jenkinson Studio Manager: Steve Greenwood.
Jennifer Colosimo is the President of the Enterprise Division at FranklinCovey and Co-Author of Strikingly Different Selling. Also joining is Howard Brown, Founder and CEO at Revenue.io. Jennifer shares how they facilitate behavior change in leadership, individuals, culture, and how they execute sales strategies. She highlights the importance of storytelling for effective selling and the value of coaching to see certain red lights that you shouldn't blow through. They also talk about being relevant, distinct, and memorable and how your differentiator makes you strikingly different. HIGHLIGHTS Simulations improve sales strategies Change the perception: Tell stories and solve legitimate concerns Coaching teaches how not to blow through red lights Giving sympathy vs providing empathy Find your differentiator that engages clients in your story QUOTES Jennifer: "It falls on us to develop, really when you think about this book, the storytelling skills. I mean, we use storytelling metaphors when you're trying to capture attention." Jennifer: "Are you relevant to what they need? And then, does it have some distinction to where we started the conversation? It might be relevant but can I see the differentiator between you? And is it memorable? Which requires work on your end to be that clear, concise storyteller." Howard: "Empathy is asking you a set of open-ended questions, getting you talking, understanding a little bit more about you, getting you to clarify so you understand even more about the situation, and how you got—then I can be empathic. But without the understanding and the open-ended questions and the ability to really reflect, all you're doing is providing sympathy." Jennifer: "There's one skill set that's how do you create excitement, how do you connect, how do you engage? And then, there's this other skill set that you validate and co-create. So I think you have to be able to flow back and forth between those." Find out more about Jennifer and get her book in the links below: LinkedIn: https://www.linkedin.com/in/jennifercolosimo/ Website: https://www.franklincovey.com/ Reach Howard in the link below: LinkedIn: https://www.linkedin.com/in/howardbrown/ More on Andy: Connect on LinkedIn Learn more at AndyPaul.com Sponsored by: Revenue.io | Unlock exponential growth with an AI-powered RevOps platform | Revenue.io Explore the Revenue.io Podcast Universe: Sales Enablement Podcast RevOps Podcast Selling with Purpose Podcast
HEALTH NEWS · Fermented red clover extract stops menopausal hot flushes and symptoms · Resveratrol, quercetin could provide new options for cancer therapy · World's largest study shows the more you walk, the lower your risk of death, even if you walk fewer than 5,000 steps · Brains of overweight people 'ten years older' than lean counterparts at middle-age · Soy protein found to deplete testosterone in men · Study shows endometriosis is linked to higher risk of depression, anxiety, eating disorders Fermented red clover extract stops menopausal hot flushes and symptoms Aarhus University (Denmark), July 24, 2023 The vast majority of women in the menopause are familiar with the status of Red Clover as an herbal medicine that soothes hot flush symptoms and hormonal fluctuations. This holds true, new research shows, if the red clover is taken in a fermented form. Fermented Red Clover extract is demonstrated to decrease significantly both the number and severity of daily hot flushes. The study also found that the extract prevents the normally accelerated menopausal bone loss affecting one in three women over the age of 50 (e.g. results showed treatment blunted bone loss in the spine completely). These findings are very promising as the benefits take place without any of the side effects of traditionally proscribed hormone therapies that increase the risk of cancers and cardiovascular diseases. "It is the fermentation process of the Red Clover extract that makes the difference, as the lactic acid fermentation increases the bioavailability of the bioactive estrogen-like compounds (known as isoflavones or phytoestrogens) that Red Clover has in abundance," explains Max Norman Tandrup Lambert. "The challenge with isoflavones is that they can be difficult to digest as they naturally occur in the plant bound to sugar molecules which prevent absorption. Hence, a large proportion of the isoflavones that are consumed (e.g. as a pill or capsule) can pass through the intestine without entering circulation. This problem is bypassed when the Red Clover extract undergoes a fermentation process. To be technical the process separates the sugar molecules from the isoflavones, thereby increasing bioavailability," explains Max Norman Tandup Lambert. A studyrecruited 130 women with menopause symptoms, of which 60 were selected based on criteria of at least five severe hot flushes per day and blood tests (including FSH, that indicates the "stage" of menopause). "The women were separated into two groups of 30, so 30 drank 150ml Red Clover extract per day for 12 weeks, whilst the other 30 drank a masked placebo product. After 12 weeks we tested again and were speechless about the data. There was a much greater effect than we had hoped for." Says Max Norman Tandrup Lambert. Resveratrol, quercetin could provide new options for cancer therapy Oregon State University, July 16, 2023 Resveratrol and quercetin, two polyphenols that have been widely studied for their health properties, may soon become the basis of an important new advance in cancer treatment, primarily by improving the efficacy and potential use of an existing chemotherapeutic cancer drug. In laboratory experiments, researchers at Oregon State University have developed a system to increase the bioavailability of these compounds in the body by using "copolymers" that make them water soluble and allow their injection into the blood stream, creating levels that are far higher than could ever be obtained by diet or oral intake. The resveratrol and quercetin then appear to reduce the cardiac toxicity of a very widely used cancer drug, Adriamycin. Although highly effective in the treatment of lymphomas, breast, ovarian and other cancers, Adriamycin can only be used for a limited time in humans because of its cardiotoxicity. The co-administration of these polyphenols might allow much more extensive use of this drug, while at the same time improving its efficacy and demonstrating the polyphenols' own anti-cancer properties, scientists said. Findings on this research have been published in the Journal of Controlled Release, by scientists from the College of Pharmacy at Oregon State University and the School of Pharmacy at Pacific University. Both institutions supported the research. "The co-administration of high levels of resveratrol and quercetin, in both in vitro and in vivo studies, shows that it significantly reduces the cardiac toxicity of Adriamycin," Alani said. "And these compounds have a synergistic effect that enhances the efficacy of the cancer drug, by sensitizing the cancer cells to the effects of the drug." It's possible, Alani said, that after further research it could be demonstrated that use of these compounds can completely eliminate the cardiotoxicity of Adriamycin, as they scavenge the toxic free radicals produced by use of this drug. It's also possible, he said, that administration of these natural polyphenols could have value in cancer therapy by themselves, or in combination with a wider range of other chemotherapeutic drugs. World's largest study shows the more you walk, the lower your risk of death, even if you walk fewer than 5,000 steps Medical University of Lodz (Poland) & Johns Hopkins University School of Medicine, August 8, 2023 The number of steps you should walk every day to start seeing benefits to your health is lower than previously thought, according to the largest analysis to investigate this. The study, published in the European Journal of Preventive Cardiology, found that walking at least 3967 steps a day started to reduce the risk of dying from any cause, and 2337 steps a day reduced the risk of dying from diseases of the heart and blood vessels (cardiovascular disease). However, the new analysis of 226,889 people from 17 different studies around the world has shown that the more you walk, the greater the health benefits. The risk of dying from any cause or from cardiovascular disease decreases significantly with every 500 to 1000 extra steps you walk. An increase of 1000 steps a day was associated with a 15% reduction in the risk of dying from any cause, and an increase of 500 steps a day was associated with a 7% reduction in dying from cardiovascular disease. The researchers, led by Maciej Banach, Professor of Cardiology at the Medical University of Lodz, Poland, and Adjunct Professor at the Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, found that even if people walked as many as 20,000 steps a day, the health benefits continued to increase. They have not found an upper limit yet. "Our study confirms that the more you walk, the better," says Prof. Banach. "We found that this applied to both men and women, irrespective of age, and irrespective of whether you live in a temperate, sub-tropical or sub-polar region of the world, or a region with a mixture of climates. In addition, our analysis indicates that as little as 4,000 steps a day are needed to significantly reduce deaths from any cause, and even fewer to reduce deaths from cardiovascular disease." There is strong evidence that a sedentary lifestyle may contribute to an increase in cardiovascular disease and a shorter life. Studies have shown that insufficient physical activity affects more than a quarter of the world's population. More women than men (32% versus 23%), and people in higher income countries compared to low-income countries (37% versus 16%) do not undertake a sufficient amount of physical activity. The studies analyzed by the researchers followed up participants for a median (average) of seven years. The mean (average) age was 64, and 49% of participants were female. In people aged 60 years or older, the size of the reduction in risk of death was smaller than that seen in people aged younger than 60 years. In the older adults, there was a 42% reduction in risk seen in those who walked between 6,000 and 10,000 steps a day, while there was a 49% reduction in risk in younger adults who walked between 7,000 and 13,000 steps a day. Brains of overweight people 'ten years older' than lean counterparts at middle-age University of Cambridge, August 4, 2023 From middle-age, the brains of obese individuals display differences in white matter similar to those in lean individuals ten years their senior, according to new research led by the University of Cambridge. White matter is the tissue that connects areas of the brain and allows for information to be communicated between regions. Our brains naturally shrink with age, but scientists are increasingly recognising that obesity - already linked to conditions such as diabetes, cancer and heart disease - may also affect the onset and progression of brain ageing; however, direct studies to support this link are lacking. The team studied data from 473 individuals between the ages of 20 and 87, recruited by the Cambridge Centre for Aging and Neuroscience. The researchers divided the data into two categories based on weight: lean and overweight. They found striking differences in the volume of white matter in the brains of overweight individuals compared with those of their leaner counterparts. Overweight individuals had a widespread reduction in white matter compared to lean people. They discovered that an overweight person at, say, 50 years old had a comparable white matter volume to a lean person aged 60 years, implying a difference in brain age of 10 years. Strikingly, however, the researchers only observed these differences from middle-age onwards, suggesting that our brains may be particularly vulnerable during this period of ageing. "As our brains age, they naturally shrink in size, but it isn't clear why people who are overweight have a greater reduction in the amount of white matter," says first author Dr Lisa Ronan from the Department of Psychiatry at the University of Cambridge, "We can only speculate on whether obesity might in some way cause these changes or whether obesity is a consequence of brain changes." Soy protein found to deplete testosterone in men University of Connecticut, July 27, 2023 The health detriments of soy consumption are reiterated in a new study out of the University of Connecticut that highlights the importance of avoiding soy at all costs. Researchers from the school found that men who consume soy protein rather than whey protein for muscle recovery and growth experience considerable reductions in their testosterone levels, as well as marked increases in levels of the stress hormone cortisol. Published in the Journal of the American College of Nutrition (JACN), the randomized, placebo-controlled crossover study looked at how soy supplementation affects testosterone, cortisol and sex hormone-binding globulin (SHBG) levels in men who engage in resistance exercises and training. They compared these effects to those brought about in men who supplement with whey. For the research, 10 resistance-trained men in their early 20s had their hormones evaluated in conjunction with an assigned supplemental diet. The men were divided into three groups: one receiving whey protein isolate, one receiving soy protein isolate and the last receiving a maltodextrin-based placebo control. The men were not allowed to take any other supplements, and vegetarians, vegans and individuals who were consuming high-protein diets were excluded. For two weeks, the men were told to ingest 20 grams of their assigned supplement every morning at the same time. The participants were then instructed to perform six sets of heavy resistance squats at 10 reps each, exerting 80 percent of their maximum lifting weight. At the end of the 14-day period, the researchers collected hormone profiles from each of the men and made comparisons. They found that, compared to the men who supplemented with whey, those taking soy did not necessarily produce more estrogen. They did, however, experience decreased testosterone levels and elevated cortisol levels, a deadly combination that can leave men at risk of disease and weight gain. Lowered testosterone levels and elevated cortisol levels are also generally attributed to the feminization phenomenon occurring in men that sometimes leads to disorders like nipple discharge, breast enlargement and hot flashes. It can also lead to inhibited thyroid function, bone loss, sleeping disorders, decreased sex function and reproductive problems. Study shows endometriosis is linked to higher risk of depression, anxiety, eating disorders Yale University, August 7, 2023 Endometriosis is not just a condition that affects the pelvis, but a systemic disease that involves the entire body. Now, the largest epidemiological study to date on the psychiatric factors that can accompany endometriosis has demonstrated that depression, anxiety, and eating disorders are not only a result of the chronic pain endometriosis generates, but also have their own underlying genetic mechanisms. The team published its findings in JAMA Network Open. "The relationship between endometriosis and mental health is more complicated than we expected," says Renato Polimanti, Ph.D., associate professor of psychiatry and the study's principal investigator. "The biological basis is not just chronic pain, and there is much more that we need to understand." Endometriosis is an extremely painful condition in which tissue similar to the lining of the uterus (endometrium) grows outside the uterus. The disease manifests in a wide array of symptoms including pelvic, abdominal, and low back pain, heavy bleeding, painful sexual intercourse, painful urination and bowel movements, constipation or diarrhea, bloating, nausea, fatigue, and infertility. In this new study, the Yale research team obtained data from the UK Biobank which included more than 8,200 patients with endometriosis and 194,000 healthy controls. First, they investigated if depression, anxiety, and eating disorders were more prevalent in those with endometriosis, accounting for chronic pain, socioeconomic status, age, body mass index, various medications, and co-morbid conditions. They found that having endometriosis significantly increases the odds of having these three psychiatric conditions. through running a genetic correlation analysis, they found a significantly high genetic correlation between endometriosis and each of the three disorders.
A new editorial paper was published in Oncotarget's Volume 14 on May 12, 2023, entitled, “Targeting H3K27me3 loss in pediatric brain tumors - a perspective on epigenetically guided cancer therapy.” High-grade tumors of the central nervous system, including medulloblastoma, ependymoma and DMG (diffuse midline glioma, formerly known as DIPG (diffuse intrinsic pontine glioma)), constitute a major challenge in pediatric oncology. They are characterized by an aggressive growth and high relapse rates and claim the lives of many pediatric cancer patients. Both medulloblastoma and ependymoma are treated with surgical resection followed by adjuvant radiation therapy. DMG, on the other hand, diffusely infiltrates the brain stem making a resection virtually impossible. Thus, radiotherapy is the primary treatment modality for this tumor. While radiation temporarily attenuates the progression of DMG this brain cancer remains incurable and most children succumb to their disease. In his new editorial, Dr. Michael Goldstein from Johns Hopkins University School of Medicine discusses the extensively investigated molecular profiles of the aforementioned pediatric brain tumors demonstrating distinct epigenetic traits. “Strikingly, a global loss of H3K27 tri-methylation (H3K27me3) as a result of the dominant-negative histone H3K27M mutation was found to be a hallmark of DMG occurring in the majority of the tumors.” H3K27me3 is a product of the EZH2 histone methyltransferase affecting multiple cellular processes including transcription, chromatin structure and DNA damage response. Similarly, the aggressive PFA ependymoma subgroup is characterized by a lack of H3K27me3 due to an overexpression of the EZHIP protein that acts as an EZH2 inhibitor whereas less aggressive PFB tumors retain normal H3K27me3 levels. However, no comprehensive analysis of H3K27me3 expression patterns in medulloblastoma has been performed and the significance of this epigenetic mark in pediatric brain tumors has remained unknown. “To address this, we have investigated the levels of the H3K27me3 histone mark and its role in treatment response of non-WNT/SHH medulloblastoma comprising group 3 and group 4 tumors. We demonstrated that about 50% of the tumors in patients with group 3 and group 4 medulloblastoma are H3K27me3 deficient. Strikingly, loss of H3K27me3 was associated with high relapse rates and poor survival.” DOI - https://doi.org/10.18632/oncotarget.28427 Correspondence to - Michael Goldstein - mgolds33@jhu.edu Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28427 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, epigenetics, brain tumor, EZH2, H3K27me3, radiation therapy About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957
On this episode of Amplified Voices, Amber and Jason speak with C, a woman who has lived through the unimaginable - losing her mother at a young age, getting thrust into the foster system, and grappling with overdiagnosis and overmedication, displacement, and disconnection. We learn about her journey, from her challenging upbringing to her involvement in the sex trade and her initial encounters with the criminal legal system as a young, transgender woman.C talks about the labels society imposes, and the struggles of being over-stigmatized within an oppressive system. We listen to C's experiences in a men's prison facility, the threats she faced, as well as her fight for proper healthcare. Strikingly, C shares about obtaining academic success amidst this turbulence- reminding us of the strength of the human spirit, and the power of belief and investment.Finally, we dive into the world of policy sentencing, its implications on individuals like C, and the immense courage it takes to stand against the system. This episode is more than a story; it's a call to thought, a plea for understanding, and a catalyst for change.She has written for Filter Magazine, Shadowproof, the Appeal, Yes! Magazine and maintains an active presence on Twitter.Support the show
Augmented reveals the stories behind the new era of industrial operations, where technology will restore the agility of frontline workers. Jim Huntzinger, President of Lean Frontiers, joins us in this episode for a deep dive into the lean business model and all things lean accounting. We explore value stream versus product costing, the importance of lean coaching, the principles of Toyota Kata, and how these strategies can drive processes improvement and product development simultaneously. Throughout the conversation, we examine the value of transforming traditional business practices and the potential impact on organizational decision-making and growth. If you like this show, subscribe at AugmentedPodcast.co (https://www.augmentedpodcast.co/). If you liked this episode, you might also like Episode 108: Lean Operations (https://www.augmentedpodcast.co/108) with John Carrier, or Episode 84: The Evolution of Lean (https://www.augmentedpodcast.co/84) with Torbjørn Netland. Augmented is a podcast for industry leaders, process engineers, and shop floor operators, hosted by futurist Trond Arne Undheim (https://trondundheim.com/) and presented by Tulip (https://tulip.co/). Follow the podcast on Twitter (https://twitter.com/AugmentedPod) or LinkedIn (https://www.linkedin.com/company/75424477/). Trond's Takeaway: The lean business model is attractive to many manufacturing firms and still elusive to some of them, despite many examples of the principles in action popping up constantly. The business community should still spend more time on the interface between tech, logistics, and IT, and how all of that might interface with lean accounting. Strikingly, what we might think of as lean companies don't necessarily use lean practices across their business. Special Guest: Jim Huntzinger.
Strikingly, sin and the Law have been closely linked. The Law is said to bring the knowledge of sin (3:20), increase sin (5:20), and arouse sinful passions (7:5). Paul now clarifies. He extols the Law as holy and yet shows that it is at the same time helpless to enable what it commands. While the fault lies with the sinner, not the Law, the fact remains that the Law is helpless to justify or sanctify. Sanctification, or growing in the life and likeness of Christ, is Paul's primary concern in this section of his letter. And in this we see again the grand glory of Christ for righteousness, positionally and practically. Only union with Christ secures both justification and sanctification.
This month on Episode 46 of Discover CircRes, host Cynthia St. Hilaire highlights four original research articles featured in the March 3 and March 17th issues of Circulation Research. This episode also features an interview with Dr Andrew Hughes and Dr Jessilyn Dunn about their review, Wearable Devices in Cardiovascular Medicine. Article highlights: Delgobo, et al. Deep Phenotyping Heart-Specific Tregs Sun, et al. Inhibition of Fap Promotes Cardiac Repair After MI Sun, et al. Endosomal PI3Kγ Regulates Hypoxia Sensing Johnson, et al. Hypoxemia Induces Minimal Cardiomyocyte Division Cindy St. Hilaire: Hi, and welcome to Discover CircRes, the podcast of the American Heart Association's Journal, Circulation Research. I'm your host, Dr Cindy St. Hilaire from the Vascular Medicine Institute at the University of Pittsburgh, and today I'm going to share four articles selected from the March 3rd and March 17th issues of CircRes. I'm also going to have a discussion with Dr Andrew Hughes and Dr Jessilyn Dunn about their review, Wearable Devices in Cardiovascular Medicine. And the Review is also featured in our March 3rd issue. Cindy St. Hilaire: First, the highlights. The first article I'm going to present is Myocardial Milieu Favors Local Differentiation of Regulatory T-Cells. The first author is Murilo Delgobo and the corresponding author is Gustavo Campos Ramos. After myocardial infarction, the release of autoantigens from the damaged heart cells activates local and infiltrating immune cells such as the T-cell. Studies in mice have shown that fragments of the muscle protein myosin can act as autoantigens, and these myosin fragments are the dominant driver of the T-cell response. But how do these myosin specific T-cells behave in the damaged heart to drive inflammation and repair is unknown. To find out, Delgobo and colleagues studied endogenous myosin specific T-cells, as well as those transferred into recipient mice. They found, whether exogenously supplied or endogenously created, the myosin specific T-cells that accumulated in the animals' infarcted hearts tended to adopt an immunosuppressive T-regulatory phenotype. Strikingly, even if the exogenous cells were differentiated into inflammatory TH-17 cells prior to transfer, a significant proportion of them were still reprogrammed into T-regs within the heart. Although cells pre-differentiated into an inflammatory TH-17 phenotype were less inclined to change after the transfer, the results nevertheless indicate that, by and large, the infarcted heart promotes T-cell reprogramming to quell inflammation and drive repair. Yet exactly how the heart does this is a question for future studies. Cindy St. Hilaire: The next article I'm going to present is titled Inhibition of FAP Promotes Cardiac Repair by Stabilizing BNP. The first authors of the study are Yuxi Sun and Mengqiu Ma, and the corresponding author is Rui Yue, and they are from Tongji University. After myocardial infarction, there needs to be a balance of recovery processes to protect the tissue. Fibrosis, for example, acts like an immediate bandaid to hold the damaged heart muscle together, but fibrosis can limit contractile function. Similarly, angiogenesis and sufficient revascularization is required to promote survival of cardiomyocytes within the ischemic tissue and protect heart function. To better understand the balance between fibrotic and angiogenic responses, Sun and colleagues examined the role of fibroblasts activated protein, or FAP, which is dramatically upregulated in damaged hearts, and brain natriuretic peptide, or BNP, which promotes angiogenesis in the heart. In this study, they found that genetic deletion or pharmacological inhibition of FAP in mice reduces cardiac fibrosis and improves angiogenesis and heart function after MI. Such benefits are not seen if BNP or its receptor, NRP-1, are lacking. The in vitro experiments revealed that FAP's protease activity degrades BNP, thus inhibiting the latter's angiogenic activity. Interestingly, while FAP is upregulated in the heart, its levels drop in the blood, showing that BNP inhibition is localized. Together, these results suggest that blocking FAP's activity in the heart after MI could be a possible strategy for protecting the muscle's function. Cindy St. Hilaire: The next article I want to present is Hypoxia Sensing of Beta-Adrenergic Receptor is Regulated by Endosomal PI-3 Kinase Gamma. The first author of this study is Yu Sun, and the corresponding author is Sathyamangla Naga Prasad. Hypoxia is the most proximate acute stress encountered by the heart during an ischemic event. Hypoxia triggers dysfunction of the beta-adrenergic receptors, beta-1AR and beta-2AR, which are critical regulators of cardiac function. Under normoxic conditions, activation of PI3K-gamma by beta-adrenergic receptors leads to feedback regulation of the receptor by hindering its dephosphorylation through inhibition of protein phosphatase 2A or PP2A. Although it is known that ischemia reduces beta-adrenergic receptor function, the impact of hypoxia on interfering with this PI3K feedback loop was unknown. Using in vitro and in vivo techniques, this group found that activation of PI3K-gamma underlies hypoxia sensing mechanisms in the heart. Exposing PI3K-gamma knockout mice to acute hypoxia resulted in preserved cardiac function and reduced beta-adrenergic receptor phosphorylation. And this was due to a normalized beta-2AR associated PP2A activity, thus uncovering a unique role for PI3K-gamma in hypoxia sensing and cardiac function. Similarly, challenging wild-type mice post hypoxia with dobutamine resulted in an impaired cardiac response that was normalized in the PI3K-gamma knockout mice. These data suggests that preserving beta-adrenergic resensitization by targeting the PI3K-gamma pathway would maintain beta-adrenergic signaling and cardiac function, thereby permitting the heart to meet the metabolic demands of the body following ischemia. Cindy St. Hilaire: The last article I want to highlight is Systemic Hypoxia Induces Cardiomyocyte Hypertrophy and Right Ventricle Specific Induction of Proliferation. First author of this study is Jaslyn Johnson, and the corresponding author is Steven Houser, and they're at Temple University. The cardiac hypoxia created by myocardial infarction leads to the death of the heart tissue, including the cardiomyocytes. While some procedures such as reperfusion therapy prevent some cardiomyocyte death, true repair of the infarcted heart requires that dead cells be replaced. There have been many studies that have attempted new approaches to repopulate the heart with new myocytes. However, these approaches have had only marginal success. A recent study suggested that systemic hypoxemia in adult male mice could induce cardiac monocytes to proliferate. Building on this observation, Johnson and colleagues wanted to identify the mechanisms that induced adult cardiomyocyte cell cycle reentry and wanted to determine whether this hypoxemia could also induce cardiomyocyte proliferation in female mice. Mice were kept in hypoxic conditions for two weeks, and using methods to trace cell proliferation in-vivo, the group found that hypoxia induced cardiac hypertrophy in both the left ventricle and the right ventricle in the myocytes of the left ventricle and of the right ventricle. However, the left ventricle monocytes lengthened while the RV monocytes widened and lengthened. Hypoxia induced an increase in the number of right ventricular cardiomyocytes, but did not affect left ventricular monocyte proliferation in male or in female mice. RNA sequencing showed upregulation of cell cycle genes which promote the G1 to S phase transition in hypoxic mice, as well as a downregulation of cullen genes, which are the scaffold proteins related to the ubiquitin ligase complexes. There was significant proliferation of non monocytes in mild cardiac fibrosis in the hypoxic mice that did not disrupt cardiac function. Male and female mice exhibited similar gene expression patterns following hypoxia. Thus, systemic hypoxia induced a global hypertrophic stress response that was associated with increased RV proliferation, while LV monocytes did not show increased proliferation. These results confirm previous reports that hypoxia can induce cardiomyocyte cell cycle activity in-vivo, and also show that this hypoxia induced proliferation also occurs in the female mice. Cindy St. Hilaire: With me today for our interview, I have Dr Andrew Hughes and Dr Jessilyn Dunn, and they're from Vanderbilt University Medical Center. And they're here to discuss the review article that they helped co-author called Wearable Devices in Cardiovascular Medicine. And just as a side note, the corresponding author, Evan Brittain, unfortunately just wasn't able to join us due to clinical service, but they're going to help dissect and discuss this Review with us. Thank you both so much for joining me today. Andy, can you just tell us a little bit about yourself? Andy Hughes: Yeah, thank you, Cindy. I'm Andy Hughes. I'm a third year medicine resident at Vanderbilt University who is currently on an NIH supported research year this year. And then will be applying to cardiology fellowships coming up in the upcoming cycle. Cindy St. Hilaire: Great, thank you. And Jessilyn, I said you are from Vanderbilt. I know you're from Duke. It was Evan and Andy at Vanderbilt. Jessilyn, tell us about yourself. Jessilyn Dunn: Thanks. I am an Assistant Professor at Duke. I have a joint appointment between biomedical engineering and biostatistics and bioinformatics. The work that my lab does is mainly centered on digital health technologies in developing what we call digital biomarkers, using data from often consumer wearables to try to detect early signs of health abnormalities and ultimately try to develop interventions. Cindy St. Hilaire: Thank you. We're talking about wearable devices today, and obviously the first thing I think most of us think about are the watch-like ones, the ones you wear on your wrists. But there's really a whole lot more out there. It's not just Apple Watches and Fitbits and the like. Can you just give us a quick summary of all these different types of devices and how they're classified? Jessilyn Dunn: Yeah, absolutely. We have a wide variety of different sensors that can be useful. A lot of times, we like to think about them in terms of the types of properties that they measure. So mechanical properties like movement, electrical properties like electrical activity of the heart. We have optical sensors. And so, a lot of the common consumer wearables that we think about contain these different types of sensors. A good example that we can think about is your consumer smartwatch, like an Apple Watch or a Fitbit or a Garmin device where it has something called an accelerometer that can measure movement. And oftentimes, that gets converted into step counts. And then it may also have an optical sensor that can be used to measure heart rate in a particular method called PPG, or photoplethysmography. And then some of the newer devices also have the ability to take an ECG, so you can actually measure electrical activity as well as the optical based PPG heart rate measurement. These are some of the simpler components that make up the more complex devices that we call wearables. Cindy St. Hilaire: And how accurate are the measurements? You did mention three of the companies, and I know there's probably even more, and there's also the clinical grade at-home ECG machines versus the one in the smartwatch. How accurate are the measurements between companies? And we also hear recent stories about somebody's Apple Watch calling 911 because they think they're dead, things like that. Obviously, there's proprietary information involved, but how accurate are these devices and how accurate are they between each other? Jessilyn Dunn: This is a really interesting question and we've done quite a bit of work in my lab on this very topic, all the way from what does it mean for something to be accurate? Because we might say, "Well, the more accurate, the better," but then we can start to think about, "Well, how accurate do we need something to be in order to make a clinical decision based off of that?" And if it costs significantly more to make a device super, super accurate, but we don't need it to be that accurate to make useful decisions, then it actually might not be serving people well to try to get it to that extreme level of accuracy. So there are a lot of trade-offs, and I think that's a tough thing to think about in the circumstances, is these trade-offs between the accuracy and, I don't know, the generalizability or being able to apply this to a lot of people. That being said, it also depends on the circumstances of use. When we think about something like step counts, for example, if you're off by a hundred step counts and you're just trying to get a general view of your step counts, it's not that much of a problem. But if we're talking about trying to detect an irregular heart rhythm, it can be very bad to either miss something that's abnormal or to call something abnormal that's not and have people worried. We've been working with the Digital Medicine Society to develop this framework that we call V3, which is verification, analytic validation and clinical validation. And these are the different levels of analysis or evaluation that you can do on these devices to determine how fit for purpose are they. Given the population we're trying to measure in and given what the goal of the measurement is, does the device do the job? And what's also interesting about this topic is that the FDA has been evolving how they think about these types of devices because there's, in the past, been this very clear distinction between wellness devices and medical devices. But the problem is that a lot of these devices blur that line. And so, I think we're going to see more changes in the way that the FDA is overseeing and potentially regulating things like this as well. Cindy St. Hilaire: These consumer-based devices have started early on as the step counters. When did they start to bridge into the medical sphere? When did that start to peak the interest of clinicians and researchers? Jessilyn Dunn: Yeah, sure. What's interesting is if we think back to accelerometers, these have been used prior to the existence of mobile phones. These really are mechanical sensors that could be used to count steps. And when we think about the smartwatch in the form that we most commonly think of today, probably looking back to about 2014 is when ... maybe between 2012, 2014 is when we saw these devices really hitting the market more ... Timing for when the devices that we know as our typical consumer smartwatch today was around 2012 to 2014. And those were things that were counting steps and then the next generation of that added in the PPG or photoplethysmography sensor. That's that green light when we look on the back of our watch that measures heart rate. And so, thinking back to the early days, probably Jawbone, there was a watch called Basis, the Intel Basis watch. Well, it was Basis and then got acquired by Intel. Fitbit was also an early joining the market, but that was really the timing. Cindy St. Hilaire: How good are these devices at actually changing behavior? We know we're really good at tracking our steps now and maybe monitoring our heartbeat or our oxygen levels. How good are they at changing behavior though? Do we know yet? Andy Hughes: Yeah, that's a great question and certainly a significant area of ongoing research right now with physical activity interventions. Things that we've seen right now is that simple interventions that use the wearable devices alone may not be as effective as multifaceted interventions. And what I mean by that is interventions that use the smartwatch but may be coupled with another component, whether that is health education or counseling or more complex interventions that use gamification or just in time adaptive interventions. And gamification really takes things to another level because that integrates components, competition or support or collaboration and really helps to build upon features of behaviors that we know have an increased likelihood of sustaining activity. With that being said, that is one of the challenges of physical activity interventions, is the sustainability of their improvements over the course of months to years. And something that we have seen is the effects do typically decrease over time, but there is work on how do we integrate all of these features to develop interventions that can help to sustain the results more effectively. So we have seen some improvement, but finding ways to sustain the effects of physical activity is certainly an area of ongoing research. Cindy St. Hilaire: I know it's funny that even as adults we love getting those gold stars or the circle completions. All of these devices, whether it's smartwatches like we're just talking about, or the other things for cardiac rehabilitation, they're generating a ton of data. What is happening with all this data? Who's actually analyzing it? How is it stored and what's that flow through from getting from the patient's body to the room where their physician is looking at it? Andy Hughes: And that is certainly a challenge right now that is limiting the widespread adoption of these devices into routine clinical care is, as Jessilyn mentioned. The wearables generate a vast amount of data, and right now, we need to identify and develop a way as clinicians to sort through all of the noise in order to be able to identify the information that is clinically meaningful and worthy of action without significantly increasing the workload. And a few of the barriers that will be necessary in order to reach that point is, one, finding ways to integrate the wearables' data into the electronic health record and also developing some machine learning algorithms or ways with which we can use the computational power of those technologies to be able to identify when there is meaningful data within all of the vast data that comes from wearables. So it's somewhere that certainly we need to get to for these devices to reach their full clinical potential, but we are limited right now by a few of those challenges. Jessilyn Dunn: I was just going to say, I will add on to what Andy was saying about this idea behind digital biomarkers because this fits really nicely with this idea that giving people this huge data deluge is not helpful, but if we had a single metric where we can say, "Here's the digital biomarker of step count, and if you're above some threshold, you're good to go. And if you're below some threshold, some intervention is needed." That's a lot of the work that we've been doing, is trying to develop what are these digital biomarkers and how can they be ingested in a really digestible way? Cindy St. Hilaire: Yeah, that's great. Regarding the clinical and the research grade devices, I know a Fitbit or Apple Watch can sometimes be used for those, but I guess I'm talking also about the other kind of more clinically oriented devices, how good is compliance and how trustable is that data? Everybody's on probably their best behavior when they're in the office with the physician or if they're on the treadmill in the cardiac lab, but home is a different story. And what don't we know about compliance when people are out of the office and the reliability of that data that's generated in that space? Andy Hughes: I think you touched on a really important point right here, and one of the potential advantages of these wearable devices is that they provide continuous long-term monitoring over the course of weeks to months to years as opposed to those erratic measurements that we get from the traditional office visits or hospitalizations where, for example, the measurements we're taking are either in a supervised environment with a six-minute walk distance, for example, or self-reported or questionnaires. So we build upon that information, but then additionally, we go beyond the observer effect where many individuals, the first week or two that you're wearing this new device, you may be more prone to increase your activity because you know that you're being monitored or you have this novel technology, but as you wear it for months to years, you outgrow those potential biases and you really can garner more comprehensive information. In terms of compliance, we can speak to some of the research studies that have either really struggled with compliance and that limits the interpretability of their results and something we'll need to address in the future, but I think that's something that can be addressed with future studies keeping in mind all of the advantages that these devices offer compared to some of the traditional measures that we have used in the past. Cindy St. Hilaire: With all this data we're collecting, whether it be biological data or even just behavioral data, have we actually learned anything new? And I mean that in terms of All Of Us study this, I don't know, it was like 5,000 patients I think, and lo and behold, it found out that higher step count correlated with lower risk for a ton of diseases, which is not exactly groundbreaking. So are we, at this point in time, learning anything new from the use of these at-home devices, or are they really just able to help us enforce what we thought we knew regarding behavior? Andy Hughes: I think these devices have certainly provided some novel insights that build upon our understanding of physical activity. Many of us can hypothesize that decreased activity would have poor outcomes on health, which the studies have demonstrated in many facets. But in reference to All Of Us study that you mentioned, I think it's interesting to look as well at some of the diagnoses or conditions that were associated with decreased activity. For example, reflux disease was also highlighted in that study, which may not have been identified if we didn't have the vast data and ability to really look for associations with diseases that have not been previously studied or thought to be related to physical activity. So I think that's one of the strong features of that database, is the wealth of knowledge that really will be hypothesis generating and help to inform future studies as we look even beyond cardiovascular conditions. Cindy St. Hilaire: One question, and you did bring it up in a bit of the discussion in your piece, is the bias that is in these devices. We know from COVID at-home pulse oximeters do not work as efficiently on darker skin. We actually know that going into bathrooms with the hand sensors that spit out the paper towels. So what kind of disparities or biases do these devices create or reinforce in the population? Jessilyn Dunn: This is such a critical topic because a lot of these issues had been discovered retrospectively because the people who were developing the technologies were not the representative of the people who were using the technologies. I think that's something that across the board we've been looking at from device development to AI implementation, which is having people who are going to be using the devices in the process of developing the technology and having voices heard from across the board. We did a detailed look when we were evaluating devices for their accuracy at this exact question of where the heart rate sensors in smartwatches use optical based technology. And there was some evidence that was also an issue for people with varying skin tones, for people with wrist tattoos or more hair or freckles. And so, we did a deep dive and the generation of devices that we looked at which would meet this study was probably about three years ago. We didn't see any discrepancies. And so, that's just one study and there are many more to be done, but I think prior to the technology development as well as once the technology comes out, keeping an eye on how that technology is doing, whether there are continued reports of failure of the technologies is really important. And there are a lot of ways that we can be vigilant about that. Cindy St. Hilaire: Yeah, that's great. And so, Andy, regarding patient populations, I can also see perhaps socioeconomic implications of this because smartwatches are not cheap. So how do we see that in terms of helping our patients? Are we going to be able to get a smartwatch through our insurance company? Andy Hughes: I think that's one of the really important next steps, is finding ways to make sure that as we advance the field of wearable devices in clinical care, that we recognize some of the existing inequities in terms of access to care, access to digital technologies that currently exist, and find ways by partnering with health insurance companies and the industry and providers and members of that community, finding ways to not only advance wearables, but use it in a way that we can decrease health disparities by really helping to increase access for these digital technologies to the underserved communities. Jessilyn Dunn: Yeah, the beauty of these technologies is that truthfully, at their core, they're very cheap. They're not difficult to develop, they're not difficult to build and disseminate. So a lot of what we think about is the infrastructure that goes around these devices. Does it require a smartphone to transfer data? Does it require internet access? What are the other pieces that need to be in place for these devices to work within an ecosystem? So this starts to get to questions beyond the devices themselves, but there's certainly a lot to think about and be done in the area of equity and ensuring that these devices can help everyone. Cindy St. Hilaire: And there's also the, I guess, ethical considerations of who owns this data. Obviously, if it's a consumable that you went and bought at Target, that's probably different than the one you're getting from your cardiologist. But who owns the data? Who has access to it? And are there any cases in the literature where an individual who's had certain measurements taken, have those measurements come back to bite them? And I guess I'm thinking of something like cardiac rehab. If a patient doesn't get up and move enough or doesn't follow their physical therapy enough or lose weight quick enough, could their insurance coverage get cut? Could their premiums go up? What safeguards are in place for these very tricky situations? Are there safeguards in place? Andy Hughes: And on the clinical side, I think it will be important to treat this information just like any other protected health information that we have as part of the electronic health record. And so, there will be inherently safeguards around that in a similar manner for how we treat other protected health information. But I think another important component of that will be a very clear consent policy when we reach the point that patients are consenting to include this information and their electronic health record, in terms of what the proposed benefits are and the potential risks associated with it, because it really is a vast amount of unique data that needs to be protected and safeguarded. And part of that comes by treating it as protected health information, but we will also need to make sure that there's a very clear consent policy that goes with it. Cindy St. Hilaire: Yeah. What do we see as the next steps in wearable devices? What do you guys see as the next big thing? I know one's coming from the actual AI and device side of things, and the other one is coming from the clinical side of things. What do each of you see as the next thing in this field? Jessilyn Dunn: I think on the device and AI side of things, I think we're thinking toward improving battery life, increasing the suite of sensors that are being added to these devices so we have a wider variety of measurements that are more representative of physiology, and then better algorithms to have better detection of sleep or activity or certain types of activity or certain types of arrhythmias. This combination of hardware and software and algorithms, I think coming together as all of these different pieces evolve will show us some really cool technology in the years to come. Andy Hughes: And I think from a clinical side, it's really twofold moving forward. I think as Jessilyn mentioned, there's a lot of novel sensor technologies that have a lot of exciting and evolving potential that we can hopefully integrate into the clinical space, but on the other hand, it's how can we use these wearable devices to enhance traditional therapies that we're already using? For example, if we take the heart failure population, is there a way that we can use the wearable devices and the existing measurements with heart rate and physical activity and blood pressure to find a way to improve remote management and safely up-titrate guideline directed medical therapy, which are medications that we know have clinical benefit. But can we augment their clinical benefit and their utility by using some of the existing technologies that we already have? And then lastly, building upon the initial studies with larger trials in more diverse generalizable populations to really enhance our understanding of the benefits that these devices may have for different cardiovascular conditions. Cindy St. Hilaire: Well, this was wonderful. Dr Andrew Hughes and Dr Jessilyn Dunn, thank you so much for joining me. The review, Wearable Devices in Cardiovascular Medicine, will be out in our March 3rd issue of Circulation Research. I forget which one, so I'll have to edit that out. Thank you so much for joining us, and I learned a ton. This was great. Jessilyn Dunn: Thank you. Andy Hughes: Thank you. Cindy St. Hilaire: That's it for our highlights from the March 3rd and March 17th issues of Circulation Research. Thank you for listening. Please check out the Circulation Research Facebook page and follow us on Twitter and Instagram with the handle @CircRes and #DiscoverCircRes. Thank you to our guests, Dr Andrew Hughes and Dr Jessilyn Dunn. This podcast is produced by Ishara Ratnayaka, edited by Melissa Stoner, and supported by the editorial team of Circulation Research. Some of the copy texts for the highlighted articles is provided by Ruth Williams. I'm your host, Dr Cindy St. Hilaire, and this is Discover CircRes, you're on-the-go Source for the most exciting discoveries in basic cardiovascular research. This program is copyright of the American Heart Association, 2023. The opinions expressed by speakers in this podcast are their own, and not necessarily those of the editors or of the American Heart Association. For more information, visit ahajournals.org.
God noticed parallels in the rebellious acts of the serpent-tempter and the man. Strikingly the text of Genesis 3 is written out in 6 parallel points as God addresses each one of them. The way the passage is written reinforces the meaning of what is told us in these verses.The woman did not share in any of these 6 parallels yet many people lump her in with the other two. This is sloppy exegesis.This section of Dr. Joy Fleming's book, Man and Woman in Biblical Unity, Theology from Genesis 2-3, reveals truths in the text that have been buried by generations of bad theology. You may want to relisten to this episode. Want to help spread this clear teaching? Become a Tru Partner. Click here: tru316.com/member
Hadi Radwan is an amateur biohacker, which was a new term for me, and means trying to DIY your own biology. He is a family man, and enjoys playing fantasy sports. He's also a podcaster, and regularly interviews founders on his podcast, the First 100, to learn how those people obtained their first 100 customers. When it comes to family, he just had a newborn, so most of his time is devoted to that.Hadi and his team took a hard look at the the market, and realized that 1 out of 4 people are disabled in their career due to an unforeseen circumstance. Strikingly, 50% of folks are living paycheck to paycheck, and don't even know disability insurance existed. They decided to build a product based on technology that fills this gap.This is the creation story of Asteya.SponsorsAirbyteDopplerHost.ioIPInfomablSupportZebraLinksWebsite: https://www.asteya.world/LinkedIn: https://www.linkedin.com/in/hadiradwan/Support this podcast at — https://redcircle.com/code-story/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
On August 26 2017 two kayakers on the Red river in North Dakota, came across a body wrapped in plastic and duct tape hung up on a log around 545pm. It was later determined to be 22 year old Savanna LaFontaine-Greywind. A native woman who was reported missing on August 19. A couple was arrested earlier that week on suspicion of conspiracy to commit kidnapping. They were also in possession of a newborn child that the police believed was Greywind's. Join us today in this horrific true crime edition of Nightmares of the Americas. Our women, girls, and two-spirts are being taken from us in an alarming way. As of 2016, the National Crime Information Center has reported 5,712 cases of missing American Indian and Alaska Native women and girls. Strikingly, the U.S Department of Justice missing persons database has only reported 116 cases. The majority of these murders are committed by non-Native people on Native-owned land. The lack of communication combined with jurisdictional issues between state, local, federal, and tribal law enforcement, make it nearly impossible to begin the investigative process. According to some tribes, red is the only color the spirits can see. By wearing red, it is everyone's hope that we can call back the missing spirits of our Indigenous sisters and daughters and lay them to rest. For more information on the MMIW movement follow the link belowhttps://www.nativewomenswilderness.org/mmiw Merch store- https://indigenoustales.threadless.com/Email us at info@behillnetwork.com Also check out our Instagram -https://www.instagram.com/indigenous_tales/And our TikTok -https://www.tiktok.com/@indigenous_talesAmanda Bland Dallas area Bakeryinstagram - https://www.instagram.com/cupidsweetsbakes/Cupid Sweets- https://www.facebook.com/cupidsweets
In 2016, psychologist Dr. Peter Langman compiled biographical data on 56 American school shooters. He found that 82% had grown up in dysfunctional family situations, usually without two biological parents at home. The trend has sadly continued. The shooter in Uvalde, Texas, hadn't lived with his father in years. The Sandy Hook shooter hadn't seen his father in the two years leading up to that massacre. Last month, new research from the Institute for Family Studies demonstrated, once again, how important fathers are, especially for boys. For example, boys growing up without their dads are only half as likely to graduate from college as their peers who live with dad at home. Strikingly, those numbers remain steady even after controlling for other factors such as race, income, and general IQ. Boys without a dad at home are also almost twice as likely to be “idle” in their late twenties, defined as neither working nor in school, and are significantly more likely to have been arrested or incarcerated by the time they turn 35. These are only a few of the data points which demonstrate that fatherlessness is one of the most pressing crises our culture is facing. Why doesn't our culture talk more about this? One reason is that this crisis intersects other “third rails.” Our culture got to this point via the sexual revolution, which encouraged promiscuity by redefining freedom and prioritizing autonomy over responsibility. When sex outside of marriage becomes normal, it is mostly women who are left on their own to raise the resulting children. There are other contributing factors as well, many of which were made possible by legislation. Divorce has been largely destigmatized, not in small part by making it legally easier. The legal demand for same-sex “marriage” brought with it the demand for same-sex parenting, which by definition asserts that kids do not need both a mother and a father. Certain forms of assisted reproduction likewise assert that children are less the fruit of a committed marriage than they are a commercial process. And now here we are, with 32% of American boys growing up in homes without their biological dads. If there's anything that we should learn from the grim outcomes of this social experiment, it is that dads aren't replaceable. This was true from creation, but even more so in a fallen world with each of us born with a fallen human nature. We only learn to grow from socially, emotionally, and spiritually immature children into adults so that we can live together in a healthy way by seeing healthy behavior modeled and by having unhealthy behavior corrected. Scripture passages affirm that mentoring in righteousness requires demonstration, as much or more than just explanation. Christ repeatedly told his followers to “do as He did.” When He washed His disciples' feet, He offered it as an object lesson: “I give you an example, that you also should do as I did to you.” Paul told believers in Corinth and Ephesus to be “imitators” of him, just as he was an “imitator of Christ.” In other places, Scripture even points to modelling and mimicry in sex-specific ways. In his letter to Titus, Paul instructed men to be “dignified” and “self-controlled” and to “urge the younger men to be self-controlled.” He also told the older women to “teach what is good” and to “train the younger women” to be “self-controlled,” “pure” and “kind.” That, of course, is another cultural third rail. We are so desperate to pretend sexual difference isn't built into our biological reality, we simply cannot abide the suggestion that our genders are critically important in parenting. But the numbers don't lie. As Dr. Ryan Anderson, president of the Ethics and Public Policy Center, puts it, “[T]here is no such thing as ‘parenting.' There is mothering, and there is fathering—children do best with both.” Christians can challenge the growing public safety crisis that is fatherlessness, and we must start in the Church. We must affirm, in word and in action, that there are men and there are women and that both matter in parenting. We have to de-normalize absent dads, challenge men to take responsibility for their sexual choices and for their children, and fill in the gaps whenever and however necessary. No matter if our technologies and cultural dogmas pretend otherwise, every child has a father. These new statistics show, again, that every child needs their father. We have no right to deprive them of
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