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Warning: This episode contains strong language and mentions of suicide.Over the past year, the federal government has taken a series of actions widely seen as attacks on the First Amendment.Greg Lukianoff, the head of a legal defense group called the Foundation for Individual Rights and Expression, speaks to Natalie Kitroeff about what free speech really means and why both the left and the right end up betraying it.Guest: Greg Lukianoff, the president and chief executive of the Foundation for Individual Rights and Expression.Background reading: Read Mr. Lukianoff's guest essay for New York Times Opinion from September.Photo: Moriah Ratner for The New York TimesFor more information on today's episode, visit nytimes.com/thedaily. Transcripts of each episode will be made available by the next workday. Subscribe today at nytimes.com/podcasts or on Apple Podcasts and Spotify. You can also subscribe via your favorite podcast app here https://www.nytimes.com/activate-access/audio?source=podcatcher. For more podcasts and narrated articles, download The New York Times app at nytimes.com/app.
This solo episode explores the quiet places where anorexia meets identity and expression. Dr. Marianne Miller speaks to the lived moments where someone learns to hide parts of themselves and how restriction becomes a language for survival. She examines how identity formation, self-expression, and body-based fear interact in ways that often remain hidden. The episode centers queer, trans, gender-expansive, and questioning listeners along with anyone who has felt pressure to quiet their identity in order to navigate the world. Dr. Marianne describes how anorexia rises when identity feels unsafe, unrecognized, or tightly controlled. She explains how restriction becomes a strategy to manage visibility, vulnerability, dysphoria, and the cultural pressure to stay small. The episode invites listeners to imagine recovery as a process of expanding expression, reclaiming autonomy, and restoring connection to their authentic self. Key Themes in This Episode Dr. Marianne examines the links between anorexia, identity, and self-expression. She describes how gender expectations and cultural norms shape the body story. She explains how queer and trans people often restrict to soften dysphoria or to quiet unwanted attention. She explores the way over-performance and people-pleasing silence authentic expression and strengthen restrictive behavior. She looks at the sensory landscape of anorexia and describes how neurodivergent experiences influence embodiment and identity. She also highlights the role of intersectionality. Race, culture, queerness, disability, and body size shape how someone expresses themself and how safe that expression feels. These intersections help explain why anorexia often becomes a predictable response to environments that restrict identity or punish authenticity. Why This Episode Matters Mainstream conversations about anorexia often focus on food without addressing identity, expression, and cultural pressure. Many listeners learn early that their identity takes up too much space. Many learn that desire, gender expression, and emotional truth need to stay hidden. This episode challenges the idea that anorexia develops inside a vacuum. Instead, it shows how anorexia forms inside relationships, systems, and environments that silence real expression. The episode offers validation for anyone who felt forced to shrink in order to stay safe. It expands the understanding of anorexia so listeners can see their experiences reflected with accuracy, compassion, and liberation. Who This Episode Supports This episode supports listeners who navigate anorexia while holding queer, trans, or gender-expansive identities. It supports people who experience identity suppression or dysphoria and who use restriction to manage that conflict. It supports neurodivergent listeners whose sensory experiences shape their relationship with their body and their identity. It also supports clinicians, loved ones, and community members who want a more accurate and compassionate understanding of anorexia. Resources Mentioned Liberation-based healing models Trauma-informed care Queer embodiment research Neurodivergent eating disorder literature Content Caution This episode discusses anorexia, restrictive eating, identity conflict, gender dysphoria, sexuality, sensory overwhelm, and the lived experience of shrinking to stay safe. Please listen with care and pause whenever your body needs space. Related Episodes Queer Mental Health & Eating Disorders: How Stress Shows Up in the Body & Brain With Winter Groeschl, NCC, LPC (@eatingdisorderrevealed): Apple & Spotify. LGBTQIA+, the Coming Out Process, & Eating Disorders: Apple & Spotify LGBTQIA+ & Eating Disorders: Apple & Spotify Learn More and Get Support Dr. Marianne Miller provides therapy and coaching for anorexia, ARFID, binge eating disorder, bulimia, trauma, and body-based fear. She supports clients across California, Texas, Washington D.C., and internationally. Explore additional episodes of the Dr. Marianne Land podcast for conversations about eating disorder recovery, neurodiversity, identity, embodiment, and body liberation. Check out her website at drmariannemiller.com. Follow her on Instagram @drmariannemiller.
In this episode of Healthy Mind, Healthy Life, host Avik Chakraborty sits down with scientist, biotech leader and debut novelist Shivani Malik to unpack how grief can quietly reroute a life that looks “perfect” on paper. Shivani shares how losing her mother. the person who championed her move from India to the US for a PhD and a career in cancer research. forced her to ask a hard question. Am I building the life I truly choose. or the one that was handed to me as the immigrant gold standard Her debut novel “The Sky Is Different Here” becomes the container for that inquiry. blending STEM and storytelling to explore grief, ambition, belonging, identity, women in STEM and the emotional cost of chasing the immigrant dream. If you have ever hit your goals and still felt strangely empty. this conversation will land close to home and give you pragmatic language and tools to actually sit with your emotions instead of outrunning them. About The Guest: Shivani Malik is a scientist, immigrant, biotech leader and debut novelist. She moved from India to the United States for her PhD. trained at Stanford and UCSF and built a high impact career in cancer research and drug development. After the sudden death of her mother. Shivani began writing as a way to process unresolved grief and question the version of success she had been running toward. That process eventually became her debut novel “The Sky Is Different Here.” a work of fiction rooted in real emotional truths about loss, belonging and the complexity of being a woman, immigrant and dream chaser. Today she continues her work in biotech while using story as a way to build community around shared struggle, invisible expectations and the cost of never slowing down. Key Takeaways: Grief will not stay in the background forever. Shivani reached a point in her postdoctoral training where the “unopened package of grief” for her mother made it impossible to keep functioning on autopilot. The immigrant dream can silently become an emotional contract. She names how passion for science and external expectations blend. making it hard to tell where genuine desire ends and cultural pressure begins. Fiction gave her psychological safety. By fictionalizing roughly shaped versions of her lived experience. she could tell the emotional truth without exposing specific people, institutions or workplaces. Science and storytelling share the same backbone. In the lab you still “tell a story” about how a cancer drug works and who it can help. That pattern of connecting dots translated directly into shaping a novel. Healing required both solitude and community. Writing helped her sit with grief. but reading other grief stories and later sharing her own created a sense of community that science culture had not given her. Everyone carries loss and dislocation. whether it is a person, a home or a sense of belonging. Shivani urges listeners to find some way to express it. through writing, conversation, walking, meditation or sitting with feelings instead of numbing them. Expression is step one. sharing is step two. Naming your experience with someone who truly “gets it” becomes a powerful way to move forward rather than just cope. How To Connect With Shivani Malik : Shivani mentioned three primary ways to reach her. Book Personal Website : You can leave her a direct message and learn more about “The Sky Is Different Here.” Want to be a guest on Healthy Mind, Healthy Life?DM on PM . Send me a message on PodMatch DM Me Here: https://www.podmatch.com/hostdetailpreview/avik Disclaimer: This video is for educational and informational purposes only. The views expressed are the personal opinions of the guest and do not reflect the views of the host or Healthy Mind By Avik™️. We do not intend to harm, defame or discredit any person, organization, brand, product, country or profession mentioned. All third party media used remain the property of their respective owners and are used under fair use for informational purposes. By watching, you acknowledge and accept this disclaimer. Healthy Mind By Avik™️ is a global platform redefining mental health as a necessity, not a luxury. Born during the pandemic. it has become a sanctuary for healing, growth and mindful living. Hosted by Avik Chakraborty. a storyteller, survivor and wellness advocate. this channel shares powerful podcasts and soul nurturing conversations on • Mental Health and Emotional Well being• Mindfulness and Spiritual Growth• Holistic Healing and Conscious Living• Trauma Recovery and Self Empowerment With over 4,400 plus episodes and 168.4K plus global listeners. we unite voices, break stigma and build a world where every story matters. Subscribe and be part of this healing journey. Contact Brand: Healthy Mind By Avik™Email: join@healthymindbyavik.com | podcast@healthymindbyavik.comWebsite: www.healthymindbyavik.comBased in: India and USA Open to collaborations, guest appearances, coaching and strategic partnerships. Let us connect to create a ripple effect of positivity. 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Send us a text✨ What if you could rewrite your inner script… and step into the timeline where you are confident, fearless, and fully expressed? In today's powerful episode, Dr. Albert Bramante— psychologist, hypnotherapist, professor, talent agent, and intuitive coach — shares the exact tools he uses to help people break cycles of trauma, conquer self-doubt, and jump timelines into success, alignment, and joy.We talk about:
On this episode, I breakdown eight little-known mobile apps that each generate around $50,000+ per month and explain why they work. I walk through specific examples—from AI video generators and Bible note-takers to vinyl pricing tools and AI English tutors—then explain the common patterns behind their success. The second half of the episode is devoted to six clear frameworks for spotting high-potential niches and designing simple, sticky mobile apps around them. I end the episode with a batch of extra startup ideas built on high-intent inputs like photos, videos, and scans so listeners can “vibe code” their own profitable apps in 2026. Timestamps 00:00 – Intro 02:02 – App 1: Flashloop: AI Video Generator for Viral Character Clips 03:26 – App 2: Bible Note-Taker & Prayer Recorder for Churchgoers 06:35 – App 3: AI Home Decor Interior Design App and Visualization Pain 08:48 – App 4: Moji Lab: Emoji/Sticker Packs and Expression as a Business 11:43 – App 5: Vinyl Snap: Scanning Vinyl Records for Accurate Pricing 13:51 – App 6: Genora AI: Bundling Multiple LLMs into One Assistant 16:45 – App 7: Logo Maker: AI Generated Logos 18:57 – App 8: Menu Fit: Healthy Eating Recommendations at Any Restaurant 20:44 – App 9: LangLearn: Personal AI English Tutor and Duolingo Comparison 22:37 – App 10: Zozo Fit 3D Body Scanner: Tracking Body Change, Not the Scale 25:04 – The “ 50K MRR App Framework” 31:30 – Bonus Startup Ideas Key Points Profitable mobile apps often do one high-intent, recurring job for a specific identity-based group, then charge a subscription around that behavior. Many breakout apps turn photos, videos, or scans (high-signal inputs) into premium insights like valuations, design plans, or tailored recommendations. Simple, one-screen interfaces with clear before/after transformations make these AI-powered tools feel approachable and addictive to use. The “50K MRR App Framework” combines spending power, repeating problems, visual inputs, accuracy needs, and bad existing tools to guide idea selection. New app ideas can be generated by pairing these frameworks with underserved niches like golf swings, pet health, used cars, or RV layouts. Numbered Section Summaries Why Mobile Apps Are Printing Money in 2026 The host opens by arguing that now is an incredible time to build mobile apps, pointing to new apps that have appeared “out of nowhere” and reached $50K+ per month. He cites a tweet listing 10 such apps launched in the last 180 days and sets the goal of reverse engineering what makes them work so listeners can apply the patterns to their own ideas. The 50K MRR App Framework The “50K MRR App Framework”: find a group that (1) spends money, (2) has a repeating problem, (3) uses photos/videos as inputs, (4) cares deeply about accuracy, and (5) suffers from bad existing tools. He walks through how vinyl collectors fit every criterion and stresses that while the framework is simple, execution still requires great UX, clean UI, and the right niche. The goal is to make idea selection easier by checking all five boxes before committing to an app. Six Supporting Frameworks for Designing Hit Apps I expands into six additional frameworks: start with a “nerve” (identity, urgency, stakes, repetition); solve one job that always must be done; build around a single high-intent input (photo, address, object); use AI to unlock a premium insight (price, diagnosis, summary, design plan); wrap it in a simple, desirable interface (one screen, one button, one transformation); and create a recurring behavior loop that pulls users back daily or weekly. He summarizes these in a conceptual pipeline: high-intent input → AI premium insight → simple interface → recurring loop → $50K MRR. The #1 tool to find startup ideas/trends - https://www.ideabrowser.com LCA helps Fortune 500s and fast-growing startups build their future - from Warner Music to Fortnite to Dropbox. We turn 'what if' into reality with AI, apps, and next-gen products https://latecheckout.agency/ The Vibe Marketer - Resources for people into vibe marketing/marketing with AI: thevibemarketer.com Startup Empire - get your free builders toolkit to build cashflowing business - https://startup-ideas-pod.link/startup-empire-toolkit Become a member - https://startup-ideas-pod.link/startup-empire FIND ME ON SOCIAL X/Twitter: https://twitter.com/gregisenberg Instagram: https://instagram.com/gregisenberg/ LinkedIn: https://www.linkedin.com/in/gisenberg/
Most parents know what goes into raising children: the time spent changing diapers in inopportune places; the hours of worrying—about what to feed them, how to educate them, how to protect them and keep them healthy; the countless hours devoted to dance classes, summer camps, pediatricians, and piano lessons—all investments meant to give them the best chance in life. Most of us would do anything to help our kids become the most successful and happiest versions of themselves. But what if we could start earlier? At the molecular level. What if we could ensure our babies were healthier, smarter, and stronger, before they even took their first breath? Right now, several biotech companies are doing just that. They offer embryo screening for couples undergoing in vitro fertilization (IVF). These companies don't just score embryos for disease risk, which has become standard practice for anyone undergoing IVF—they go further. Nucleus Genomics promises “optimization” of traits like heart health and cancer resistance, as well as intelligence, longevity, body mass index, baldness, eye color, hair color, etc. It even suggests it may predict a predisposition to become an alcoholic. In the future, we may be able to more than just screen and select. We'll be able to make tweaks to our own embryos in order to “optimize” them. This isn't something out of Aldous Huxley's Brave New World. It's the very real, and near, future. Some would argue it's already here. It all creates profound and critical questions. So we hosted a debate: Is it ethical to design our unborn children? And are we morally obligated to do so when the risks of abstaining include serious diseases? Or does designing babies cross a line? Is it wrong to play God and manipulate humanity's genetic heritage? Arguing that designing babies is not only an ethical choice, but indeed a moral imperative, are Jamie Metzl and Dr. Allyson Berent. Jamie is a technology and healthcare futurist, who was a member of the World Health Organization Expert Advisory Committee on Human Genome Editing. He's also written several best-selling books on this subject, including Hacking Darwin: Genetic Engineering and the Future of Humanity. Allyson is a veterinarian who has become an incredible force for genetic research since her daughter, Quincy, was diagnosed with Angelman syndrome. She serves as chief science officer of the Foundation for Angelman Syndrome Therapeutics and chief development officer at a biotechnology company, where she helps accelerate gene therapy programs for Angelman syndrome. Arguing that designing babies is unethical are O. Carter Snead and Dr. Lydia Dugdale. Carter is a bioethicist and law professor at Notre Dame. He served as general counsel to the President's Council on Bioethics under George W. Bush and as an appointed member of UNESCO's International Bioethics Committee. He is also an appointed member of the Pontifical Academy for Life, which advises the pope on bioethics. Lydia is a physician, medical ethicist, and professor of medicine at Columbia University, where she serves as director of the Center for Clinical Medical Ethics. She is also Co-Director of Clinical Ethics at NewYork-Presbyterian Hospital/Columbia University Irving Medical Center. It's a critical debate you won't want to miss. The Free Press is honored to have partnered with the Foundation for Individual Rights and Expression to present this debate. Head to TheFire.org to learn more about this indispensable organization. Learn more about your ad choices. Visit megaphone.fm/adchoices
Lisa Sugarman joins Something For Everybody this week. Lisa is Author, Columnist, 3x Suicide Loss Survivor and the founder of The HelpHUB™ In this conversation, Lisa and I explore the complexities of parenting, mental health, and grief. We discuss the importance of listening to children, the impact of technology on mental health, and the ongoing need for mental health awareness. Lisa shares her personal journey as a suicide loss survivor and her advocacy work in mental health, emphasizing that grief is a reflection of love. We also address misconceptions about suicide and the importance of accessible resources for those in need. - See discounts for all the products I use and recommend: https://everybodyspod.com/deals/ - Shop For Everybody Use code SFE10 for 10% OFF
So many women whisper the same thing:“I don't feel like myself anymore.”Especially after motherhood.Especially after marriage.Especially after a season of burnout or identity confusion.And the truth is: you cannot rebuild your confidence, your identity, or your feminine magnetismwithout rebuilding your daily habits.In today's episode, we're breaking down the exact Soft x Savage routines that help high-caliber women feel like themselves again — confident, grounded, disciplined, feminine, and fully in command of their lives.If you've been searching for:“how to feel like myself again after motherhood” “postpartum confidence tips” “morning routine for moms” “feminine energy routines” “how to rebuild identity after baby” “habits for confident women” “how to be consistent again”…this episode is exactly where you need to be.Inside, we talk about:Why discipline is the highest form of feminine self-respectThe difference between masculine pressure and feminine disciplineRoutines that instantly make you feel grounded, confident, and magneticThe glamour habits that reconnect you to your feminine identityNervous system rituals that stabilize your emotionsHow to rebuild your morning routine after postpartum or burnoutWhy your habits shape your identity — and your identity shapes your resultsThe reason your brand feels inconsistent (and how your routines fix it)How structure becomes the foundation for a softer, sexier, more expressive version of youThis is not a productivity episode.This is an identity episode.Because once your habits reflect the woman you're becoming —Your confidence rises, your femininity sharpens, your presence deepens, and your life finally starts matching your standards.A Soft x Savage woman doesn't hustle her way back to herself.She *disciplines* her way back.With elegance.With devotion.With desire.If you've been craving consistency, confidence, creative energy, or feminine momentum… these routines will bring you home.Similar Episodes:-Ep. 165: How to Stay Soft While Leading Like a Savage — Feminine Balance for Type-A High-Achieving Women-Ep. 166: Stop Trying to Be Who You Were — The Identity Shift That Prepares You for More-Ep. 195: The Woman Who Forgot Who She Was — and the Holy Rebuilding That FollowedYour Next Move:If this episode helped you reconnect with who you're becoming, screenshot it, share it to your Stories, and tag @itslaurapatriciamartin + @softxsavagepodcast.Tell me which routine or identity shift you're committing to — I'll be cheering you on.Resource Links:Join Bolder Branding Academy — The signature space where we rebuild the digital expression of the woman you're becoming. Identity first. Expression next. Premium presence always.Download Magnetic Messaging Mini-Training — $22 for instant depth, power, and conviction in your content.Laura's Amazon Favorites — My essentials for crafting a Soft x Savage home & lifestyle.
In this episode, I share what it means to step fully into your slut era inside a committed relationship (or in singlehood). I talk about why this energy is so powerful, how it revived my own desire, and how reclaiming the word slut can transform sex that feels flat, disconnected, or routine. In this episode, I talk about: What a “slut era” looks like in a monogamous marriage A new, empowering definition of the word slut Why long-term relationships often dull desire — and how slut energy reignites it Releasing shame, body judgment, and the “respectable woman” identity The difference between sensation and true erotic power Awakening the slut archetype for creativity, freedom, and wild pleasure Making space for taboo fantasies without fear or self-judgment How erotic energy boosts confidence, vitality, and relational intimacy Who Slut Academy is for and why community matters in this work JOIN THE WAITLIST HERE and get amazing discounts and bonuses PLUS my exclusive erotic diaries newsletter! https://www.erika-alsborn.com/s-academy-waitlist Related episodes: 25: Slut Academy 26: The Slut Archetype – what and who is she and why she'll revolutionize your sex life! 97: Erotic expansion – understanding and playing with domination and submission 34: The importance of imperfect pleasure and sex
EXCITING NEWS! Now, you can be a Superstar for as low as just $3 a month! The Future Is Magical -New platform, new format, with a super fast new server-Easy upgrade, downgrade or cancel anytime https://www.nadiyashahsuperstars.comNEW! 4-WEEK COURSE STELLAR HEALING: UNLOCK YOUR COSMIC BLUEPRINT FOR RADIANT HEALTH & VITALITYWITH LEADING MEDICAL ASTROLOGER KIRA SUTHERLAND!THIS IS ONE NOT TO BE MISSED SIGN UP BEFORE DEC 31ST TO CHOOSE YOUR TUITION RATE!Learn More now at synchronicityuniversity.comScheduleClass 1: Solar Secrets - Your Annual Health Reset Class 2: Lunar Magic - Healing with Moon Phase PowerClass 3: Nutrition and Herbs - Your Astrological Cosmic CuisineClass 4: Stellar Solutions - Live Q&A with Expert KiraNEW! 2026 JANUARY SPEAKER SERIES! WITH A PHENOMENAL LINEUP OF THE BEST OF THE BEST!SIGN UP BEFORE DEC 31ST TO CHOOSE YOUR TUITION RATE!Learn More now at synchronicityuniversity.comClass 1: Bibian Orjuela — Introduction to Astro-herbalismClass 2: Inna Segal — Understanding the Language of your BodyClass 3: Maria Alvarez — Solar Return Class 4: Amir Bey — Blending Composite and Davison Relationship ChartsClass 5: Hollis Taylor (they/them) — Gender Roles, Identities, and Expression in the Astrology Chart NEW! 5-WEEK COURSE LAUNCH YOUR ASTROLOGY PRACTICE WITH A YOUTUBE CHANNEL THAT SHINES!WITH SUPERSTAR ASTROLOGER DABNEY LAWLESSSIGN UP BEFORE DEC 31ST TO CHOOSE YOUR TUITION RATE!Learn More now at synchronicityuniversity.comScheduleClass 1: What Is Your Astrology Brand?Class 2: Networking, Organizations & EventsClass 3: Creating Astrology Videos for YouTubeClass 4: Creating Assets for YouTubeClass 5: Live Q&A Session with Expert Dabney LawlessNEW! 5-WEEK COURSE FIVE COSMIC CATALYSTS FOR YOUR BEST YEAR YET!WITH SUPERSTAR ASTROLOGER RYAN HUNTSIGN UP BEFORE DEC 31ST TO CHOOSE YOUR TUITION RATE!Learn More now at synchronicityuniversity.comScheduleCatalyst 1: The Initiator — MarsCatalyst 2: The Visionary — JupiterCatalyst 3: The Architect — SaturnCatalyst 4: The Transformer — PlutoCatalyst 5: The Awakener — UranusFRENCH VANITY FAIR Top 12 astrologers on the planethttps://shorturl.at/zDqqoREFINERY29 Top 10 astrologers on YouTube https://shorturl.at/ci5NEThank You FOR MAKING my most recent books #1 NEW RELEASE ON AMAZON ASTROLOGY BOOKS! GET MY BOOKS NOW: OF RAVENS & DRAGONFLIES: http://bit.ly/47lI24qThe Universe is Wise &Loving: https://shorturl.at/p2u2QPrayers to The Sky: https://amzn.to/38bZh6SBe Social: To interact and be in the loop on astrological happenings and inspirations... 'Like' me here: http://www.facebook.com/nadiyashahdotcomhttps://www.facebook.com/synchronicityuniversity'Follow' me here: http://twitter.com/nadiyashah'Follow' me here: http://nadiyashah.bsky.social'Follow" me here: http://instagram.com/nadiyashah http://instagram.com/nadiya_shahhttps://www.instagram.com/synchronicityuniversity/'Follow" me here: https://www.threads.net/@nadiya_shah'Follow' me here: https://www.tiktok.com/@nadiya.shahThank You for watching!*N.
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It's easy to dismiss social barriers as inevitable - the natural friction that comes with 'being different'. But it's much harder to look directly at the systems that keep people unseen, unheard, and separate from opportunity. But what if the work of genuine leadership offered something far more radical: not the removal of barriers through policy or process alone, but the daily practice of seeing people in their wholeness, and moving with them through the discomfort of that recognition?Shaun Christie-David offers a quiet counterpoint to the usual narratives around social enterprise. As founder of Plate It Forward and a collective of "Social Enterprise" restaurants, he has built organisations where empathy isn't a virtue-signaling slogan — it's woven into hiring, kitchen rhythms, and shared work. It's leadership as a sustained commitment to human dignity, grounded in his own family's experience of migration and the profound luck of belonging.KG and Paul spent time in the Podcave with Shaun, listening to a story that moves from banking to Sri Lanka to restaurants that quietly challenge every assumption about who belongs in Australian workplaces. What emerges is leadership as something far more grounded than most frameworks allow — a long game that ripples forward across generations.At the heart of Shaun's work is a disarming question: Why? Why do we assume people with criminal records are untrustworthy? Why overlook skilled migrants when organisations claim there is a talent shortage? Why reduce people to categories when what stands before us is a person with agency and capability?Ultimately we explore that, perhaps, the real work of leadership is the willingness to build something so it can live beyond you, and the insistence that your success is only meaningful if it creates conditions for the success of others.We are grateful to Annandale Cellars (and so is Shaun!) for once again generously providing a delicious bottle of wine to accompany this awe-inspiring conversation. On this occasion we are fortunate to taste a 2024 Catlow & Co Nebbiolo, from Beechworth, Victoria. It is a soft and rounded red with a long, delicious finish of red berries, roses and spice. A gorgeous, juicy wine or drink now, or store for a special day.Get at least half a dozen of these (or half a dozen of any of their amazing wines) and get a 20% discount by using our code at checkout: DECANTEDSláinte friends!Useful resources from this episode:Plate It ForwardColombo SocialKabul SocialKolkata SocialKyiv SocialWe're keen to hear what you thought of this conversation. Please let us know through either of the options below.Please reach out on askus@leadershipdecanted.com or visit us at www.leadershipdecanted.comDisagree or agree with anything we've said? How wrong are we?!? Are there any leadership topics you'd like us to discuss (or perhaps other books or podcasts that might set us straight!)? Maybe you'd like to recommend a favourite wine!Whatever tickles your fancy, we'd love to hear from you!!
durée : 00:05:27 - Expression directe Vous aimez ce podcast ? Pour écouter tous les autres épisodes sans limite, rendez-vous sur Radio France.
BLACKFRIDAY !
In this solo episode, I dive into the rapidly evolving world of AI-driven content creation and the new possibilities it opens for creators. From image generation to quote cards, infographics, whiteboard breakdowns, and visual storytelling, the tools now available let anyone bring ideas to life in ways that were nearly impossible just a few years […]
Whether you like cats or not, this is the purrfect episode to learn a lot of useful cat-related expressions that you can use to improve your spoken English.I share a list of different expressions, go over the meaning and popularity of each one, and of course give examples from my own life. If you'd like to join in the conversation, go to the comments on the shownotes page.At the end, I also share 4 things we can learn from cats to improve our lives. Do you agree?Show notes page - https://levelupenglish.school/podcast352Get access to coaching, group classes, and 100s of bonus lessons and episodes on Level Up English.➡️ Become a Member Today: https://www.levelupenglish.school/join/➡️ Join the Free Mini Course - https://www.levelupenglish.school/mini⭐️ Join Level Up English - https://www.levelupenglish.school Become a member and get: Podcast Transcripts Private Podcast Group Classes Private Coaching And over 500 online lessons!
Few lines in the Constitution have provoked as much passion—or confusion—as this one: “A well regulated Militia, being necessary to the security of a free State, the right of the people to keep and bear Arms, shall not be infringed.” What did the Founding Fathers mean by “well regulated”? What did they mean by “Militia”? And, do any of those definitions hold in 21st-century America? Guns are one of the most divisive symbols in the country. At the same time, the idea of surrendering weapons and trusting the state feels dangerous, and to many, guns are not symbols of violence, but symbols of freedom. Still, the question remains: freedom at what cost? With mass shootings now a fixture of American life, with countless families being wrecked by gun violence—what exactly are we protecting? This debate is about what the Second Amendment really means, what its limits should be, what the root causes of our gun violence are. And how, if at all, we can address them. We think about this subject a lot: Would America be safer without the Second Amendment? To debate this topic we brought together Dana Loesch and Alan Dershowitz recently in Chicago—a city that has had more than its fair share of gun violence. Alan argued yes, that America would be safer without the Second Amendment. Alan is a lawyer, a law professor for 50 years at Harvard, and the author of too many books to mention. He has litigated and won hundreds of cases in multiple countries, including his pro bono defense of dissidents such as Natan Sharansky, Václav Havel, and Julian Assange. And he is a fierce advocate for tighter gun control in the United States. Dana Loesch argued no, that America would not be safer without the Second Amendment. Dana is one of the country's top nationally syndicated talk radio hosts with The Dana Show, a television commentator, preeminent Second Amendment advocate, and author of several books, including the best-selling Hands Off My Gun: Defeating the Plot to Disarm America. She is also a former spokesperson for the National Rifle Association. It's a critical debate you won't want to miss. The Free Press is honored to have partnered with the Foundation for Individual Rights and Expression to present this debate. Head to thefire.org to learn more about this indispensable organization. Learn more about your ad choices. Visit megaphone.fm/adchoices
Episode Notes Jim O'Kane of TVDads.com takes Rob shopping at S. Klein as Garber and co try to pinpoint where the train is when is stops again.
There is a revival happening among women right now.A return.A remembering.A rising of the full woman — the regal, elegant, sensual, spiritually grounded woman who holds herself to a standard that rebuilds her entire life from the inside out.Not the watered-down version of womanhood we've been sold.Not the chaotic, burnt-out, self-sacrificing archetype we silently normalized.And not the “soft girl aesthetic” that's all ambiance and no substance.Soft x Savage is the whole woman waking up.In this episode, we are naming the identity behind the movement.The identity that rebuilt my marriage, my motherhood, my presence, and my business — but more importantly, the identity that is becoming the new standard for women who lead with depth, mystery, conviction, and class.Inside, we talk about:- The awakening of the *regal woman* — sensual, elegant, magnetic, and spiritually grounded- Why every powerful woman goes through an identity crack before she rises- How postpartum, purpose shifts, and marriage refinement expose the deeper standards you've outgrown- The identity standards that rebuild a woman's home, marriage, brand, and self—without forcing or performing- The difference between feminine softness and feminine leadership- The revival of women who want to be full, turned-on, multidimensional, creative, disciplined, wealthy, and deeply embodied- Why identity must shift *before* your brand, business, or content can elevate- The Soft x Savage woman as an emerging cultural archetype for 2026This is not a self-help episode.This is an identity recalibration for the woman you're becoming.The woman with taste.The woman with standards.The woman with presence.The woman with emotional and spiritual authority.The woman who makes her life — her home, her brand, her marriage, her body — a reflection of who she truly is.Soft x Savage is not a vibe.It's a revival.And you're here because you feel it too.Similar Episodes-Ep. 195: The Woman Who Forgot Who She Was — and the Holy Rebuilding That Followed-Ep. 166: Stop Trying to Be Who You Were — The Identity Shift That Prepares You for More-Ep. 165: How to Stay Soft While Leading Like a Savage — Feminine Balance for Type-A High-Achieving WomenYour Next MoveIf this episode spoke to your identity — screenshot it, share it to your Stories, and tag@itslaurapatriciamartin + @softxsavagepodcast.Tell me the standard you're elevating in this season — I'll be cheering you on.Resource LinksJoin Bolder Branding Academy — The signature space where we rebuild the digital expression of the woman you are becoming.Identity first. Expression next. Premium presence always.Download Magnetic Messaging Mini-Training — $22 for instant depth, power, and conviction in your content.Laura's Amazon Favorites — My essentials for crafting a soft x savage home & lifestyle.
C'est une spécialité de nos femmes et hommes politiques quand ils veulent noyer le poisson ou se sortir d'une question piège en enfilant les banalités. Ils n'en ont pas le monopole, on a déjà tous utilisé cet oxymore car c'en est un : une langue par définition est souple alors que le bois, lui, est rigide. Mais avant d'arriver en France, elle est née en Russie. Elle tire sa source dans l'Empire tsariste mais a pris tout son sens avec l'avènement de l'URSS. Dans "Ah Ouais ?", Florian Gazan répond en une minute chrono à toutes les questions essentielles, existentielles, parfois complètement absurdes, qui vous traversent la tête. Un podcast RTL Originals.Hébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.
Aujourd'hui, Joëlle Dago Serry, coach de vie, Charles Consigny, avocat, et Chirinne Ardakani, avocate, débattent de l'actualité autour d'Alain Marschall et Olivier Truchot.
A powerful exploration of what becomes possible when your body finally feels safe enough to open into its full erotic potential.If you've been craving deeper pleasure, confidence, expression, and erotic aliveness... this episode is for you.
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11-23-25 AM "The Joyful Response to Jesus"Scripture Reading: Revelation 19:1-10 Sermon Text: Mark 2:18-22I. The Question concerning the Joyful Response to Jesus A. The Situation behind the Question B. The Reminder with the QuestionII. The Reason for the Joyful Response to Jesus A. The Redemptive Explanation for the Reason B. The Parabolic Illustration of the ReasonIII. The Implications from the Joyful Response to Jesus A. An Implication concerning the Practice of Fasting B. An Implication concerning the Expression of JoyRev. Greg Lubbers
How do you turn fear into fuel and presence into power? In this high-energy, heart-centered episode of Do the Thing, Stacey Lauren welcomes the unforgettable Dr. Gary Wohlman, also known as The Presentation Doctor. With decades of experience in transformational coaching, Gary shares how full-body expression, playful embodiment, and somatic storytelling can unlock the deepest parts of your voice, your purpose, and your presence. Whether you're a speaker, coach, or simply someone who's been playing small, this episode will have you laughing, reflecting, and wildly rethinking what it means to “do the thing” on a stage, or in life. What you'll learn: - How somatic tools can shift trauma patterns - Why "multi-sensory messaging" works in the age of distraction - How to rewrite your holding-back story with laughter and movement - The PEA Formula for powerful speaking - How healing and hilarity go hand in hand 00:02 – How Stacey and Dr. Gary met: Entrepreneurs Gone Wild & My People Parties 06:40 – His 5S Speaking Method: Short, Simple, Strong, Specific, Spontaneous 11:30 – From stage fright to becoming “The Presentation Doctor” 17:55 – Somatic healing, Monty Python techniques & trauma ridiculization 32:20 – PEA Framework: Points, Examples, Application = Memorable Messaging YouTube: https://youtu.be/FGxl8sIbISg Apple Podcasts: https://podcasts.apple.com/us/podcast/from-stage-fright-to-spotlight-dr-gary-wohlman-on-embodied/id1618590178?i=1000737475416 Spotify: https://open.spotify.com/episode/3LmAV0KYsCPNegKjDE2orK
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John celebrates Become New's five-year anniversary and reflects on how this ministry was born not from strategy, but from confusion, loss, and unexpected grace. In this episode, he explores the surprising way suffering and gratitude often intertwine—looking at the Pilgrims' story and Jesus giving thanks on the night before the cross—and why the deepest gratitude can grow in our hardest moments. Remember your own seasons of pain, and take hope: God was with you then, He is with you now, and He is redeeming all things. Thank God you're here.
Freedom of Speech at Risk in Armenia, Vagharshapat, RPA Strategy | Ep 487, Nov 19, 2025Conversations on Groong - Recorded on: November 18, 2025TopicsFreedom of Expression at Risk in ArmeniaVagharshapat Municipal OutcomesRepublican Party Election StrategyStand in Support of Independent Media and Journalism in ArmeniaGuestHayk MamijanyanHostsHovik ManucharyanAsbed BedrossianEpisode 487 | Recorded: November 18, 2025SHOW NOTES: https://podcasts.groong.org/487Subscribe and follow us everywhere you are: linktr.ee/groong
Authors Drs. Jessica Ross and Alissa Cooper share insights into their JCO PO article, "Clinical and Pathologic Landscapes of Delta-Like Ligand 3 and Seizure-Related Homolog Protein 6 Expression in Neuroendocrine Carcinomas" Host Dr. Rafeh Naqash and Drs. Ross and Cooper discuss the landscape of Delta-like ligand 3 (DLL3) and seizure-related homolog protein 6 (SEZ6) across NECs from eight different primary sites. TRANSCRIPT Dr. Rafeh Naqash: Hello and welcome to JCO Precision Oncology Conversations, where we bring you engaging conversations with authors of clinically relevant and highly significant JCO PO articles. I'm your host, Dr. Rafeh Naqash, podcast editor for JCO PO and an Associate Professor at the OU Health Stephenson Cancer Center. Today, I'm excited to be joined by Dr. Jessica Ross, third-year medical oncology fellow at the Memorial Sloan Kettering Cancer Center, as well as Dr. Alissa Cooper, thoracic medical oncologist at the Dana-Farber Cancer Institute and instructor in medicine at Harvard Medical School. Both are first and last authors of the JCO Precision Oncology article entitled "Clinical and Pathologic Landscapes of Delta-like Ligand 3 and Seizure-Related Homolog Protein 6 or SEZ6 Protein Expression in Neuroendocrine Carcinomas." At the time of this recording, our guest disclosures will be linked in the transcript. Jessica and Alissa, welcome to our podcast, and thank you for joining us today. Dr. Jessica Ross: Thanks very much for having us. Dr. Alissa Cooper: Thank you. Excited to be here. Dr. Rafeh Naqash: It's interesting, a couple of days before I decided to choose this article, one of my GI oncology colleagues actually asked me two questions. He said, "Rafeh, do you know how you define DLL3 positivity? And what is the status of DLL3 positivity in GI cancers, GI neuroendocrine carcinomas?" The first thing I looked up was this JCO article from Martin Wermke. You might have seen it as well, on obrixtamig, a phase 1 study, a DLL3 bi-specific T-cell engager. And they had some definitions there, and then this article came along, and I was really excited that it kind of fell right in place of trying to understand the IHC landscape of two very interesting targets. Since we have a very broad and diverse audience, especially community oncologists, trainees, and of course academic clinicians and some people who are very interested in genomics, we'll try to make things easy to understand. So my first question for you, Jessica, is: what is DLL3 and SEZ6 and why are they important in neuroendocrine carcinomas? Dr. Jessica Ross: Yeah, good question. So, DLL3, or delta-like ligand 3, is a protein that is expressed preferentially on the tumor cell surface of neuroendocrine carcinomas as opposed to normal tissue. It is a downstream target of ASCL1, and it's involved in neuroendocrine differentiation, and it's an appealing drug target because it is preferentially expressed on tumor cell surfaces. And so, it's a protein, and there are several drugs in development targeting this protein, and then Tarlatamab is an approved bi-specific T-cell engager for the treatment of extensive-stage small cell lung cancer in the second line. SEZ6, or seizure-like homolog protein 6, is a protein also expressed on neuroendocrine carcinoma cell surface. Interestingly, so it's expressed on neuronal cells, but its exact role in neuroendocrine carcinomas and oncogenesis is actually pretty poorly understood, but it was identified as an appealing drug target because, similarly to DLL3, it's preferentially expressed on the tumor cell surface. And so this has also emerged as an appealing drug target, and there are drugs in development, including antibody-drug conjugates, targeting this protein for that reason. Dr. Alissa Cooper: Over the last 10 to 15 years or so, there's been an increasing focus on precision oncology, finding specific targets that actually drive the cancer to grow, not just within lung cancer but in multiple other primary cancers. But specifically, at least speaking from a thoracic oncology perspective, the field of non-small cell lung cancer has completely exploded over the past 15 years with the discovery of driver oncogenes and then matched targeted therapies. Within the field of neuroendocrine carcinomas, including small cell lung cancer but also other high-grade neuroendocrine carcinomas, there has not been the same sort of progress in terms of identifying targets with matched therapies. And up until recently, we've sort of been treating these neuroendocrine malignancies kind of as a monolithic disease process. And so recently, there's been sort of an explosion of research across the country and multiple laboratories, multiple people converging on the same open questions about why might patients with specific tumor biologies have different kind of responses to different therapies. And so first this came from, you know, why some patients might have a good response to chemo and immunotherapy, which is the first-line approved therapy for small cell lung cancer, and we also sort of extrapolate that to other high-grade neuroendocrine carcinomas. What's the characteristic of that tumor biology? And at the same time, what are other targets that might be identifiable? Just as Jesse was saying, they're expressed on the cell surface, they're not necessarily expressed in normal tissue. Might this be a strategy to sort of move forward and create smarter therapies for our patients and therefore move really into a personalized era for treatment for each patient? And that's really driving, I think, a lot of the synthesis of this work of not only the development of multiple new therapies, but really understanding which tumor might be the best fit for which therapy. Dr. Rafeh Naqash: Thank you for that explanation, Alissa. And as you mentioned, these are emerging targets, some more further along in the process with approved drugs, especially Tarlatamab. And obviously, DLL3 was something identified several years back, but drug development does take time, and readout for clinical trials takes time. Could you, for the sake of our audience, try to talk briefly about the excitement around Tarlatamab in small cell lung cancer, especially data that has led to the FDA approval in the last year, year and a half? Dr. Alissa Cooper: Sure. Yeah, it's really been an explosion of excitement over, as you're saying, the last couple of years, and work really led by our mentor, Charlie Rudin, had identified DLL3 as an exciting target for small cell lung cancer specifically but also potentially other high-grade neuroendocrine malignancies. Tarlatamab is a DLL3-targeting bi-specific T-cell engager, which targets DLL3 on the small cell lung cancer cells as well as CD3 on T cells. And the idea is to sort of introduce the cancer to the immune system, circumventing the need for MHC class antigen presentation, which that machinery is typically not functional in small cell lung cancer, and so really allowing for an immunomodulatory response, which had not really been possible for most patients with small cell lung cancer prior to this. Tarlatamab was tested in a phase 2 registrational trial of about 100 patients and demonstrated a response rate of 40%, which was very exciting, especially compared with other standard therapies which were available for small cell lung cancer, which are typically cytotoxic therapies. But most excitingly, more than even the response rate, I think, in our minds was the durability of response. So patients whose disease did have a response to Tarlatamab could potentially have a durable response lasting a number of months or even over a year, which had previously not ever been seen in this in the relapsed/refractory setting for these patients. I think the challenge with small cell lung cancer and other high-grade neuroendocrine malignancies is that a response to therapy might be a bit easier to achieve, but it's that durability. The patient's tumors really come roaring back quite aggressively pretty quickly. And so this was sort of the most exciting prospect is that durability of response, that long potential overall survival tail of the curve really being lifted up. And then most recently at ASCO this year, Dr. Rudin presented the phase 3 randomized controlled trial which compared Tarlatamab to physician's choice of chemotherapy in a global study. And the choice of chemotherapy did vary depending on the part of the world that the patients were enrolled in, but in general, it was a really markedly positive study for response rate, for progression-free survival, and for overall survival. Really exciting results which really cemented Tarlatamab's place as the standard second-line therapy for patients with small cell lung cancer whose disease has progressed on first-line chemo-immunotherapy. So that has been very exciting. This drug was FDA approved in May of 2024, and so has been used extensively since then. I think the adoption has been pretty widespread, at least in the US, but now in this global trial that was just presented, and there was a corresponding New England Journal paper, I think really confirms that this is something we really hopefully can offer to most of our patients. And I think, as we all know, that this therapy or other therapies like it are also being tested potentially in the first-line setting. So there was data presented with Tarlatamab incorporated into the maintenance setting, which also showed exciting results, albeit in a phase 1 trial, but longer overall survival than we're used to seeing in this patient population. And we await results of the study that is incorporating Tarlatamab into the induction phase with chemotherapy as well. So all of this is extraordinarily exciting for our patients to sort of move the needle of how many patients we can keep alive, feeling functional, feeling well, for as long as possible. Dr. Rafeh Naqash: Very exciting session at ASCO. I was luckily one of the co-chairs for the session that Dr. Rudin presented it, and I remember somebody mentioning there was more progress seen in that session for small cell lung cancer than the last 30, 35 years for small cell, very exciting space and time to be in as far as small cell lung cancer. Now going to this project, Jessica, since you're the first author and Alissa's the last, I'm assuming there was a background conversation that you had with Alissa before you embarked on this project as an idea. So could you, again, for other trainees who are interested in doing research, and it's never easy to do research as a resident and a fellow when you have certain added responsibilities. Could you give us a little bit of a background on how this started and why you wanted to look at this question? Dr. Jessica Ross: Yeah, sure. So, as with many exciting research concepts, I think a lot of them are derived from the clinic. And so I think Alissa and I both see a good number of patients with small cell, large cell lung cancer, and then high-grade neuroendocrine carcinomas. And so I think this was really born out of a basic conversation of we have these drugs in development targeting these two proteins, DLL3 and SEZ6, but really what is the landscape of cancers that express these proteins and who are the patients that really might benefit from these exciting new therapies. And of course, there was some data out there, but sort of less than one would imagine in terms of, you know, neuroendocrine carcinomas can really come from anywhere in the body. And so when you're seeing a patient with small cell of the cervix, for example, like what are the chances that their cancer expresses DLL3 or expresses SEZ6? So it was really derived from this pragmatic, clinically oriented question that we had both found ourselves thinking about, and we were lucky enough at MSK, we had started systematically staining patients' tumors for DLL3, tumors that are high-grade neuroendocrine carcinomas, and then we had also more recently started staining for SEZ6 as well. And so we had this nice prospectively collected dataset with which to answer this question. Dr. Rafeh Naqash: Excellent. And Alissa, could you try to go into some of the details around which patients you chose, how many patients, what was the approach that you selected to collect the data for this project? Dr. Alissa Cooper: This is perhaps a strength but also maybe a limitation of this dataset is, as Jesse alluded to, our pathology colleagues are really the stars of this paper here because we were lucky enough at MSK that they were really forethinking. They are absolute experts in the field and really forward-thinking people in terms of what information might be needed in the future to drive treatment decision-making. And so, as Jesse had said, small cell lung cancer tumor samples reflexively are stained for DLL3 and SEZ6 at MSK if there's enough tumor tissue. The other high-grade neuroendocrine carcinomas, those stains are performed upon physician request. And so that is a bit of a mixed bag in terms of the tumor samples we were able to include in this dataset because, you know, upon physician request depends on a number of factors, but actually at MSK, a number of physicians were requesting these stains to be done on their patients with high-grade neuroendocrine cancers of of other histologies. So we looked at all tumor samples with a diagnosis of high-grade neuroendocrine carcinoma of any histology that were stained for these two stains of interest. You know, I can let Jesse talk a bit more about the methodology. She was really the driver of this project. Dr. Jessica Ross: Yeah, sure. So we had 124 tumor samples total. All of those were stained for DLL3, and then a little less than half, 53, were stained for SEZ6. As Alissa said, they were from any primary site. So about half of them were of lung origin, that was the most common primary site, but we included GI tract, head and neck, GU, GYN, even a few tumors of unknown origin. And again, that's because I think a lot of these trials are basket trials that are including different high-grade neuroendocrine carcinomas no matter the primary site. And so we really felt like it was important to be more comprehensive and inclusive in this study. And then, methodologically, we also defined positivity in terms of staining of these two proteins as anything greater than or equal to 1% staining. There's really not a defined consensus of positivity when it comes to these two novel targets and staining for these two proteins. But in the Tarlatamab trials, for some of the correlative work that's been done, they use that 1% cutoff, and we just felt like being consistent with that and also using a sort of more pragmatic yes/no cutoff would be more helpful for this analysis. Dr. Alissa Cooper: And that was a point of discussion, actually. We had contemplated multiple different schemas, actually, for how to define thresholds of positivity. And I know you brought up that question before, what does it mean to be DLL3 positive or DLL3 high? I think you were alluding to prior that there was a presentation of obrixtamig looking at extra-pulmonary neuroendocrine carcinomas, and they actually divvied up the results between DLL3 50% or greater versus DLL3 low under 50%. And they actually did demonstrate differential efficacy certainly, but also some differential safety as well, which is very provocative and that kind of analysis has not been presented for other novel therapies as far as I'm aware. I could be wrong, but as far as I'm aware, that was sort of the first time that we saw a systematic presentation of considering patients to be, quote unquote, "high" or "low" in these sort of novel targets. I think it is important because the label for Tarlatamab does not require any DLL3 expression at all, actually. So it's not hinging upon DLL3 expression. They depend on the fact that the vast majority of small cell lung cancer tumors do express DLL3, 85% to 90% is what's been demonstrated in a few studies. And so, there's not prerequisite testing needed in that regard, but maybe for these extra-pulmonary, other histology neuroendocrine carcinomas, maybe it does matter to some degree. Dr. Rafeh Naqash: Definitely agree that this evolving landscape of trying to understand whether an expression for something actually really does correlate with, whether it's an immune cell engager or an antibody-drug conjugate is a very evolving and dynamically moving space. And one of the questions that I was discussing with one of my friends was whether IHC positivity and the level of IHC positivity, as you've shown in one of those plots where you have double positive here on the right upper corner, you have the double negative towards the left lower, whether that somehow determines mRNA expression for DLL3. Obviously, that was not the question here that you were looking at, but it does kind of bring into question certain other aspects of correlations, expression versus IHC. Now going to the figures in this manuscript, very nicely done figures, very easy to understand because I've done the podcast for quite a bit now, and usually what I try to do first is go through the figures before I read the text, and and a lot of times it's hard to understand the figures without reading the text, but in your case, specifically the figures were very, very well done. Could you give us an overview, a quick overview of some of the important results, Jessica, as far as what you've highlighted in the manuscript? Dr. Jessica Ross: Sure. So I think the key takeaway is that, of the tumors in our cohort, the majority were positive for DLL3 and positive for SEZ6. So about 80% of them were positive for DLL3 and 80% were positive for SEZ6. About half of the tumors were stained for both proteins, and about 65% of those were positive as well. So I think if there's sort of one major takeaway, it's that when you're seeing a patient with a high-grade neuroendocrine carcinoma, the odds are that their tumor will express both of these proteins. And so that can sort of get your head thinking about what therapies they might be eligible for. And then we also did an analysis of some populations of interest. So for example, we know that non-neuroendocrine pathologies can transform into neuroendocrine tumors. And so we specifically looked at that subset of patients with transformed tumors, and those were also- the majority of them were positive, about three-quarters of them were positive for both of these two proteins. We looked at patients with brain met samples, again, about 70% were positive. And then I'd say the last sort of population of interest was we had a subset of 10 patients who had serial biopsies stained for either DLL3 or SEZ6 or both. In between the two samples, these patients were treated with chemotherapy. They were not treated with targeted therapy, but interestingly, in the majority of cases, the testing results were concordant, meaning if it was DLL3 positive to begin with, it tended to remain DLL3 positive after treatment. And so I think that's important as well as we think about, you know, a patient who maybe had DLL3 testing done before they received their induction chemo-IO, we can somewhat confidently say that they're probably still DLL3 positive after that treatment. And then finally, we did do a survival analysis among specifically the patients with lung neuroendocrine carcinomas. We looked at whether DLL3 expression affected progression-free survival on first-line platinum-etoposide, and then we looked at did it affect overall survival. And we found that it did not have an impact or the median progression-free survival was similar whether you were DLL3 positive or negative. But interestingly, with overall survival, we found that DLL3 positivity actually correlated with slightly improved overall survival. These were small numbers, and so, you know, I think we have to interpret this with caution, for sure, but it is interesting. I think there may be something to the fact that five of the patients who were DLL3 positive were treated with DLL3-targeting treatments. And so this made me think of, like in the breast cancer world, for example, if you have a patient with HER2-positive disease, it initially portended worse prognosis, more aggressive disease biology, but on the other hand, it opens the door for targeted treatments that actually now, at least with HER2-positive breast cancer, are associated with improved outcomes. And so I think that's one finding of interest as well. Dr. Rafeh Naqash: Definitely proof-of-concept findings here that you guys have in the manuscript. Alissa, if I may ask you, what is the next important step for a project like this in your mind? Dr. Alissa Cooper: Jesse has highlighted a couple of key findings that we hope to move forward with future investigative studies, not necessarily in a real-world setting, but maybe even in clinical trial settings or in collaboration with sponsors. Are these biomarkers predictive? Are they prognostic? You know, those are still- we have some nascent data, data has been brewing, but I think that we we still don't have the answers to those open questions, which I think are critically important for determining not only clinical treatment decision-making, but also our ability to understand sequencing of therapies, prioritization of therapies. I think a prospective, forward-looking project, piggybacking on that paired biopsy, you know, we had a very small subset of patients with paired biopsies, but a larger subset or cohort looking at paired biopsies where we can see is there evolution of these IHC expression, even mRNA expression, as you're saying, is there differential there? Are there selection pressures to targeted therapies? Is there upregulation or downregulation of targets in response not just to chemotherapy, but for example, for other sort of ADCs or bi-specific T-cell engagers? I think those are going to be critically important future studies which are going to be a bit challenging to do, but really important to figure out this key clinical question of sequencing, which we're all contemplating in our clinics day in and day out. If you have a patient, and these patients often can be sick quite quickly, they might have one shot of what's the next treatment that you're going to pick. We can't guarantee that every patient is going to get to see every therapy. How can you help to sort of answer the question of like what should you offer? So I think that's the key question sort of underlying any future work is how predictive or prognostic are these biomarkers? What translational or correlative studies can we do on the tissue to understand clinical treatment decision-making? I think those are the key things that will unfold in the next couple of years. Dr. Rafeh Naqash: The last question for you, Alissa, that I have is, you are fairly early in your career, and you've accomplished quite a lot. One of the most important things that comes out from this manuscript is your mentorship for somebody who is a fellow and who led this project. For other junior investigators, early-career investigators, how did you do this? How did you manage to do this, and how did you mentor Jessica on this project with some of the lessons that you learned along the way, the good and other things that would perhaps help other listeners as they try to mentor residents, trainees, which is one of the important things of what we do in our daily routine? Dr. Alissa Cooper: I appreciate you calling me accomplished. Um, I'm not sure how true that is, but I appreciate that. I didn't have to do a whole lot with this project because Jesse is an extraordinarily smart, driven, talented fellow who came up with a lot of the clinical questions and a lot of the research questions as well. And so this project was definitely a collaborative project on both of our ends. But I think what was helpful from both of our perspectives is from my perspective, I could kind of see that this was a gap in the literature that really, I think, from my work leading clinical trials and from treating patients with these kinds of cancers that I really hoped to answer. And so when I came to Jessica with this idea as sort of a project to complete, she was very eager to take it and run with it and also make it her own. You know, in terms of early mentorship, I have to admit this was the first project that I mentored, so it was a great learning experience for me as well because as an early-career clinician and researcher, you're used to having someone else looking over your shoulder to tell you, "Yes, this is a good journal target, here's what we can anticipate reviewers are going to say, here are other key collaborators we should include." Those kind of things about a project that don't always occur to you as you're sort of first starting out. And so all of that experience for me to be identifying those more upper-level management sort of questions was a really good learning experience for me. And of course, I was fantastically lucky to have a partner in Jesse, who is just a rising star. Dr. Jessica Ross: Thank you. Dr. Rafeh Naqash: Well, excellent. It sounds like the first of many other mentorship opportunities to come for you, Alissa. And Jessica, congratulations on your next step of joining and being faculty, hopefully, where you're training. Thank you again, both of you. This was very insightful. I definitely learned a lot after I reviewed the manuscript and read the manuscript. Hopefully, our listeners will feel the same. Perhaps we'll have more of your work being published in JCO PO subsequently. Dr. Alissa Cooper: Hope so. Thank you very much for the opportunity to chat today. Dr. Jessica Ross: Yes, thank you. This was great. Dr. Rafeh Naqash: Thank you for listening to JCO Precision Oncology Conversations. Don't forget to give us a rating or review and be sure to subscribe so as you never miss an episode. You can find all ASCO shows at asco.org/podcasts. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Disclosures: Dr. Alissa Jamie Cooper Honoraria Company: MJH Life Scienes, Ideology Health, Intellisphere LLC, MedStar Health, Physician's Education Resource, LLC, Gilead Sciences, Regeneron, Daiichi Sankyo/Astra Zeneca, Novartis, Research Funding: Merck, Roche, Monte Rosa Therapeutics, Abbvie, Amgen, Daiichi Sankyo/Astra Zeneca Travel, Accommodations, Expenses: Gilead Sciences
SANS Internet Stormcenter Daily Network/Cyber Security and Information Security Stormcast
Decoding Binary Numeric Expressions Didier updated his number to hex script to support simple arithmetic operations in the text. https://isc.sans.edu/diary/Decoding%20Binary%20Numeric%20Expressions/32490 Tea Token NPM Pollution The NPM repository was hit with around 150,000 submissions that did not contain any useful contributions, but instead attempted to fake contributions to earn a new tea coin. https://aws.amazon.com/blogs/security/amazon-inspector-detects-over-150000-malicious-packages-linked-to-token-farming-campaign/ IBM AIX NIMSH Vulnerabilities IBM patched several critical vulnerablities in the NIMSH daemon https://www.ibm.com/support/pages/node/7251173
GS#1026 This week Chia Chou, a world renowned musician and professor, showcases his online program, Audio Golf. The course can help golfers of all skill levels achieve a repeatable rhythm that will result in hitting shots, and stroking putts more consistently. Chou challenges Fred to demonstrate the difficulty of performing contradictory actions while speaking. The discussion highlights the complexities of body language and communication, emphasizing how challenging it is to align verbal and non-verbal cues.This episode is brought to you by Warby Parker with over 300+ locations to help you find your next pair of glasses. You can also head over to warbypaker.com/golfsmarter right now to try on any pair virtually!This episode is sponsored by Indeed. Please visit indeed.com/GOLFSMARTER and get a $75 SPONSORED JOB CREDIT. Terms and conditions apply.This episode is sponsored by HIMS. Start your free online visit today HIMS.com/golfsmarter and received personalized ED treatment options.This episode is brought to you by Policygenius. Secure your family's future at Policygenius.com to compare free life insurance quotes from top companies and see how much you could save. This episode is also brought to you by Taelor, an award-winning menswear rental subscription service. Visit taelor.style and get 25% OFF your first month of men's clothing subscription with our exclusive code GOLFSMARTER.If you have a question about whether or not Fred is using any of the methods, equipment or apps we've discussed, or if you'd like to share a comment about what you've heard in this or any other episode, please write because Fred will get back to you. Either write to golfsmarterpodcast@gmail.com or click on the Hey Fred button, at golfsmarter.com
It's always a pleasure to welcome back Dr. Shane Enete—Associate Professor of Finance at Biola University, founder of Biola's Financial Planning Program, and creator of The Money Storybook Bible Podcast. His creative work helps parents disciple their children in biblical stewardship by weaving financial lessons into retold Bible stories.When asked what inspired the podcast, Dr. Enete explained that the idea grew from a common question he receives: “How can I teach my kids about money?” His realization was simple yet profound—the Bible already does this. “The Bible talks about money more than almost any other topic, and it's filled with stories for all ages,” he said. “So I thought, what if I just told these stories to my kids in a way that helped them see themselves in the story and learn about money at the same time?”Stewardship as an Expression of LoveFor Dr. Enete, the goal goes far beyond teaching budgeting or saving. “Stewardship is one of the greatest opportunities we have to express our love for Jesus,” he said. “When we share, we're loving Him and others.”He hopes parents and children alike will see money not as a source of stress or status, but as an opportunity for love, wisdom, and worship. “I want kids to understand the dangers of debt and discontentment,” he added, “but even more, I want them to know that Jesus is everything—and that money can be used to love Him.”Storytime with a PurposeEach podcast episode features Dr. Enete reading to his own children, with interactive moments that bring the stories to life. “We start with fun icebreakers, like a ‘Would you rather' question, then read a Bible story together,” he explained. “Afterward, I ask questions to help them reflect, and we finish with a hands-on activity that reinforces the lesson.”One of Dr. Enete's favorite family moments came from a story about Solomon. “I asked my kids which world they'd rather live in—one where they're rich but don't know Jesus, or one where they have Jesus but not the riches. They didn't even hesitate—they chose Jesus. That's when I knew these lessons were hitting home.”The Story of Lydia: Business as MinistryOne memorable episode, Purple Snail Robes, retells the story of Lydia from Acts 16. In Dr. Enete's version, Lydia initially wants to give away her wealth to follow Paul, but he helps her see that her business can be a ministry in itself.“Sometimes God wants us to serve Him right where we are,” Paul tells her. “When you share what you have and do your work with skill and kindness, you're showing people who Jesus is.”Dr. Enete shared that Lydia's story was inspired by the idea of Gospel Patrons—those who use their resources to fuel God's work. “Lydia was one of the first gospel patrons,” he said. “I wanted kids to see that our work and business can glorify God. Plus,” he laughed, “the fact that purple dye came from smashed snails makes it extra fun for kids!”The Story of Nicodemus: Costly GenerosityAnother powerful episode, 75 Pounds of Spices, reimagines Joseph of Arimathea and Nicodemus as they prepare Jesus' body for burial—with a young girl named Abigail watching nearby. The story illustrates generosity that is both courageous and costly, as Joseph donates his tomb and Nicodemus buys an extravagant amount of burial spices.Even little Abigail joins in, offering her treasured blue necklace to honor Jesus. “That moment shows that no act of generosity is too small,” said Dr. Enete. “It's a picture of giving that flows from love—something children can grasp in a tangible way.”Free Resources for FamiliesTo help parents extend the lessons at home, Dr. Enete created a free activity book that pairs with the podcast. It includes fun exercises, badges, and a certificate of completion—each tied to key money principles like giving, saving, and contentment.You can find the podcast and resources at WholeHeartFinances.com.At the heart of The Money Storybook Bible Podcast is a simple but transformative message: Jesus is the true treasure. Teaching kids about money isn't just about dollars and cents—it's about helping them see that every financial decision can be an act of love for God and others.As Dr. Enete put it, “More than anything, I want kids to know that money isn't the goal—knowing and loving Jesus is.”On Today's Program, Rob Answers Listener Questions:I've been diagnosed with a terminal illness and care for my four-year-old grandson. I have $100,000 in life insurance, $50,000 in retirement savings, and $20,000 in cash. How can I set up a trust and invest wisely to provide for him after I'm gone? Also, does the guardian I choose also control the trust, or must they be named separately as trustee or beneficiary?I've seen ads claiming thieves can steal your home's title unless you buy special insurance. Is that a real concern or just a scare tactic?Resources Mentioned:Faithful Steward: FaithFi's Quarterly Magazine (Become a FaithFi Partner)The Money Storybook Bible PodcastWhole Heart FinancesWhole Heart Finances: A Jesus-Centered Guide to Managing Your Money with Joy by Dr. Shane EneteWisdom Over Wealth: 12 Lessons from Ecclesiastes on MoneyLook At The Sparrows: A 21-Day Devotional on Financial Fear and AnxietyRich Toward God: A Study on the Parable of the Rich FoolFind a Certified Kingdom Advisor (CKA)FaithFi App Remember, you can call in to ask your questions every workday at (800) 525-7000. Faith & Finance is also available on Moody Radio Network and American Family Radio. You can also visit FaithFi.com to connect with our online community and partner with us as we help more people live as faithful stewards of God's resources. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
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A maximum-security prison may not seem like the natural setting for a homegrown theater program. But at Sing Sing Prison in New York, just such a project has inspired scores of incarcerated men to learn and grow through the stories they step into—offering them the chance to be part of a supportive community and equipping them with life skills to carry home when they return to the world outside. People in prison are more than just prisoners, and the Rehabilitation Through the Arts (RTA) program continues to help participants discover new strengths through creative expression. In today's episode, Michael Semanchik welcomes John “Divine G” Whitfield and Clarence “Divine Eye” Maclin—both former inmates, RTA members, and actors in the Oscar-nominated film Sing Sing—to talk about their experiences on the inside. They discuss the film project and its ability to teach the outside world about the transformative power of community, art, vulnerability, and purpose. Creativity and storytelling can restore dignity, bridge divides, and reveal the humanity that is too often overlooked within the prison system. Please visit www.FreeDivineG.org to learn the details of John “Divine G" Whitfield's fight for exoneration. John “Divine G" Whitfield is an Oscar-nominated adapted screenplay writer, executive producer, and the compelling inspiration behind the critically acclaimed, multiple Oscar-nominated film, Sing Sing. Oscar Nominee Clarence Maclin starred in the feature film Sing Sing, inspired by his life story as a graduate of Sing Sing's Rehabilitation Through the Arts program. Divine G and Clarence are friends to another former Sing Sing and RTA-involved inmate, Jon-Adrian “JJ” Velazquez, whose long and arduous exoneration was shared in our last episode. Listen to JJ's story here: A Murdered Cop and a Mishandled Mugshot – JJ Velazquez's Wrongful Conviction Learn more about your ad choices. Visit megaphone.fm/adchoices
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In this episode, I talk with Julia Middleton, founder of Women Emerging, about how women everywhere are redefining what it means to lead. Julia shares how her global “expeditions” help women discover their own authentic way of leading and introduces her Four E's framework — Essence, Elements, Expression, and Energy. We explore why traditional models of leadership don't always fit women, how to lead in alignment with who you are, and the courage it takes to lead your way in systems not designed for you.
Aujourd'hui, Jean-Loup Bonnamy, prof de philo, Flora Ghebali, militante dans la transition écologique, et Charles Consigny, avocat, débattent de l'actualité autour d'Alain Marschall et Olivier Truchot.
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Imnemnimi Podcasters Arrested:Freedom of Expression at Risk in ArmeniaConversations on GroongTopicsArrest of Imnemnimi PodcastersWhat are the Government's Real Intentions?Silence of the WestCall to All Media: Cover Aggressions Against Freedom of Expression in Armenia!GuestArthur KhachikyanHostsHovik ManucharyanAsbed BedrossianEpisode 485 | Recorded: November 14, 2025SHOW NOTES: https://podcasts.groong.org/485Subscribe and follow us everywhere you are: linktr.ee/groong
In this episode of the Pediatric and Developmental Pathology, our hosts Dr. Mike Arnold (@MArnold_PedPath) and Dr. Jason Wang speak with Dr. Mukul Vij of the Department of Pathology, Dr. Rela Institute & Medical Centre, Chennai, Tamil Nadu, India and with Dr. Vaibhav Shah, a Pediatric Gastroenterologist and Hepatologist at Gujarat Super Speciality Clinic, Ahmedabad, Gujarat, India. Hear about an uncommon type of childhood cirrhosis that was first described in India, and how the incidence and recognition of this entity has changed over time as we talk about their article in Pediatric and Developmental Pathology: Indian Childhood Cirrhosis: Report of 2 Cases With Review of Literature and Implication of Metallothionein Immunohistochemical Expression Featured public domain music: Summer Pride by Loyalty Freak
In this cross-post episode, Lewis and Michael go through some fun conversation questions that involve a lot of British English idioms and slang.While hearing our funny stories, you'll improve your knowledge of spoken English and train your listening.Show notes page - https://levelupenglish.school/podcast350Get access to coaching, group classes, and 100s of bonus lessons and episodes on Level Up English.➡️ Become a Member Today: https://www.levelupenglish.school/join/➡️ Join the Free Mini Course - https://www.levelupenglish.school/mini⭐️ Join Level Up English - https://www.levelupenglish.school Become a member and get: Podcast Transcripts Private Podcast Group Classes Private Coaching And over 500 online lessons!
Find us at www.crisisinvesting.com In this episode, Doug and Matt reconnect after a long hiatus to discuss pressing issues in politics and economics. They analyze the bizarre relationship between Trump and an Al-Qaeda figure, the alarming state of free speech legislation in South Korea, and the absurdity of 15-year car loans. They also touch on the implications of tariffs, the unemployment crisis among college graduates, and the future prospects in a world increasingly influenced by AI and robotics. Towards the end, they passionately promote their book aimed at helping young men navigate these turbulent times. 00:00 Introduction and Catching Up 00:21 Al-Qaeda and Trump: A Bizarre Alliance 03:38 Hate Speech and Freedom of Expression 05:36 The Absurdity of 15-Year Car Loans 11:15 Capital Controls and Financial Restrictions 15:58 Trump's Tariff Dividends and Corruption 21:12 Trump's World Coin and Financial Maneuvering 21:59 The Rise of Humanoid Robots 23:35 Somali Political Dynamics in Minneapolis 26:42 US-Venezuela Relations and Narco-Terrorism 33:08 The Crisis of College Graduates and Employment 34:10 Promoting the Book: A Solution for Young Men 42:04 Conclusion and Call for Questions
Your voice is the bridge between who you are and how you lead. So how can you be heard and be remembered, even in toxic workplaces? In this episode we are joined by Lily Lapenna, MBE, communication coach and facilitator, honored by Queen Elizabeth for her impact work, and Amy Ewbank, expert in voice and former professional actor and Head of HR. Amy Ewbank and Lily Lapenna are Co-CEO's at Verve Leaders They share how to express your true essence and the art of joyful communication. You'll discover: The 3 Es Framework (Essence, Expression, Environment) that transforms the way you communicate. What Prince William taught me about communication in 3 minutes. How to listen to what's not being said, and create trust through attunement. How to pitch, present, and persuade with storytelling that enchants. The secret confidence technique of powerful speakers. What every great pitch needs to land, that most people avoid. Amy Ewbank and Lily Lapenna are Co-CEO's at Verve Leaders Lily Lapenna, MBE, is a communication geek working with professional to help them get heard and be remembered. She works in academic institutions Like Harvard and Oxford university on business and communication. She is a passionate coach and facilitator around all things communication. She was honored by Queen Elizabeth with an MBE for her social impact work. Connect with Lily: https://www.linkedin.com/in/lilylapenna/ Amy Ewbank is a leadership coach, communication strategist, and expert in voice. She began her career as a professional actor, performing in repertory theatre, BBC Radio, and Channel 4 amongst others. She also has experience working as Head of HR at a UK national charity, she has been featured on Sky News, Channel 5 and The Guardian for her work on the stage and beyond. Connect with Amy: https://www.linkedin.com/in/amy-ewbank-45158a231/ Elevate your communication skills with Verve: https://www.verveleaders.com/ ✅ Free Newsletter: https://assertiveway.com/newsletter/ ✅ Take the Quiz 'Do You Speak Like a High-Impact Leader?': https://myassertiveway.outgrow.us/highimpactleader ✅ Listen on the Speak Your Mind Unapologetically podcast on Apple Itunes: https://podcasts.apple.com/us/podcast/speak-your-mind-unapologetically-podcast/id1623647915 ✅ Listen on Spotify: https://open.spotify.com/show/6L1myPkiJXYf5SGrublYz2 ✅ Order our book, 'Unapologetic Voice: 101 Real-World Strategies for Brave Self Advocacy & Bold Leadership' where each strategy is also a real story: https://www.amazon.com/Unapologetic-Voice-Real-World-Strategies-Leadership-ebook/dp/B0CW2X4WWL/ ✅ Follow the show host, Ivna Curi, on LinkedIn: https://www.linkedin.com/in/ivna-curi-mba-67083b2/
I'm so thrilled to bring you this conversation with Bonnie, who shares her beautiful journey of rediscovering herself through motherhood, creativity, and deep spiritual work. If you've ever felt like becoming a mom meant losing touch with who you are — or if you've struggled with imposter syndrome and that nagging voice telling you you're not "enough" — this episode is for you. Bonnie opens up about how unused creativity doesn't just disappear — it can turn into anxiety and disconnection. But when we give ourselves permission to explore, create, and honor our authentic voice, everything shifts. We dive into the power of storytelling for women, working with the chakra system to understand and balance our emotions, and why feeling ALL your feelings is not only safe — it's necessary for personal growth. This conversation is equal parts grounding and expansive. We talk about overcoming imposter syndrome, taking small but meaningful steps toward your creative goals, and how shifting your perspective can completely transform your experience of motherhood and life. What you'll learn in this episode: How motherhood can be a powerful catalyst for self-discovery and unleashing creativity Why unused creativity often shows up as anxiety — and what to do about it The connection between your heart chakra and throat chakra, and how to balance them for authentic expression Why all your feelings are safe to feel (and how emotional safety changes everything) Practical ways to overcome imposter syndrome and trust your unique journey as a creative mom How small steps and perspective shifts can lead to profound transformation in motherhood Bonnie's approach to storytelling as a tool for empowerment, authenticity, and elevating women's voices Understanding the chakra system and using it as a guide for emotional balance and spiritual growth Sound bites you'll love: "I am enough just because I'm here." "I do what is fun and enjoyable for me." "All my feelings are safe to feel." You can find all of Bonnie's books at https://booksbybonnielippincott.com/ If today's episode resonates with you, I'd love to hear your biggest takeaway. Send me a message over on Instagram: @iamkristacannon.
It's time to dive deeper into the subtle energy system that powers your yoga practice—and your life. In Part 2 of our exploration of the Vayus, I explore Udana Vayu (upward-moving energy) and Vyana Vayu (the expansive force that integrates everything), and how they influence expression, circulation, and embodiment. We connect the Vayus to chakras, Ayurveda, mudras, and practical tools you can use to balance these energies in your body and teaching. You'll learn:
Lorcan Price of Alliance Defending Freedom International Alliance Defending Freedom International The post An Update on a Freedom of Religion and Expression Case in Finland – Lorcan Price, 10/31/25 (3043) first appeared on Issues, Etc..
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