Podcasts about HPA

In this episode, Jennifer Wallace and Elisabeth Kristof are joined in person by Dr. Lovey Bradley, NSI certified practitioner, BrainBased facilitator, and facilitator of the NSI BIPOC Affinity Group. Together they examine how racial stress and systemic oppression live in the body, how they shape nervous system patterns across generations, and what post-traumatic growth actually requires when the environment itself keeps activating survival. Dr. Lovey opens by sharing what brought her to this conversation, including a moment of messaging Elisabeth out of frustration, asking why race still has to be such a defining factor, and what it would take to start breaking those walls down. The answer they keep returning to: it starts with having the conversations. From there the episode moves into the physiology of racial stress, how chronic exposure to discrimination activates the HPA axis, elevates cortisol, suppresses progesterone, and drives the specific health disparities that show up disproportionately in melanated bodies, including fibroids, endometriosis, heart disease, hypertension, and chronic pain. Dr. Lovey names what she sees in the women she works with and connects those physical realities directly to suppressed expression, ancestral stress load, and the specific demands placed on bodies that have never had the systemic safety to soften. Elisabeth grounds the conversation in current research including the work of Resmaa Menakem on embodied racial trauma and Tema Okun's writing on white supremacy culture, which she connects directly to nervous system dysregulation rather than personality or ideology. The episode also traces how cultural conditioning normalizes threat-based behaviors like urgency, perfectionism, and emotional repression as efficiency or success, and what that means for everyone living inside those systems. Dr. Lovey also shares the story of how she accidentally created a healing community for melanated women after a single post went viral in a Facebook group, and what the response revealed about the collective hunger for real, unperformed connection. Topics Covered How racism functions as a chronic threat signal that reshapes the nervous system, not just belief or behavior What the HPA axis, cortisol, and progesterone have to do with racial stress and women's health outcomes How suppressed expression contributes to physical disease in melanated bodies What Resmaa Menakem's framework adds to neuro somatic approaches to racialized trauma Why white supremacy culture traits like urgency and perfectionism map directly onto chronic stress behaviors How the urgency to fix or regulate can itself become a form of bypassing in healing spaces What post-traumatic growth looks like at a collective level, not just an individual one Why witnessing state violence on social media is a genuine nervous system stressor, even for those not directly targeted How Dr. Levy's community for melanated women came to life and what it is building toward Chapter Markers 0:00 - Why This Conversation Had to Happen 01:57 - Welcome: Racial Trauma, the Nervous System, and Post-Traumatic Growth 07:25 - What Racial Stress Looks Like in the Body, for White and Melanated Bodies 10:44 - Post-Traumatic Growth at the Collective Level: What It Actually Requires 15:35 - The Danger of Regulating Out of Activation Before the Cycle Completes 18:09 - The Neuroscience: HPA Axis, Allostatic Load, and Chronic Racial Threat 24:27 - How Racial Stress Shows Up in Hormones, Cycles, and Women's Health 29:25 - Resmaa Menakem, White Supremacy Culture, and the Nervous System 38:42 - Dr. Levy's Community for Melanated Women and What It Is Building 41:35 - Witnessing Violence at Scale: What It Does to All Nervous Systems 49:11 - What This Work Has Made Possible: Dr. Levy on Choosing to Create a Different World 51:59 - Closing Reflection: What Post-Traumatic Growth Requires of Us Collectively Ways to Engage with Neurosomatics: Neurosomatic Intelligence is now enrolling : https://neurosomaticintelligence.com/nsi-certification Join us for a two week trial of neurosomatic practices at rewiretrial.com Free BrainBased neurosomatic workshop for entrepreneurs at rewirecapacity.com Sacred Synapse: an educational YouTube channel founded by Jennifer Wallace that explores nervous system regulation, applied neuroscience, consciousness, and psychedelic preparation and integration through Neurosomatic Intelligence.  Wayfinder Journal: Track nervous system patterns and support preparation and integration through Neurosomatic Intelligence. Learn to work with Boundaries at the level of the body and nervous system at https://www.boundaryrewire.com   Resources: Brave Heart, Maria Yellow Horse. "The Historical Trauma Response Among Natives and Its Relationship with Substance Abuse: A Lakota Illustration." Journal of Psychoactive Drugs, vol. 35, no. 1, 2003, pp. 7–13. Brave Heart, Maria Yellow Horse, and Eduardo Duran. "Healing the Soul Wound: Counseling with American Indians and Other Native Peoples." Teachers College Press, 1995. DeGruy, Joy. Post Traumatic Slave Syndrome: America's Legacy of Enduring Injury and Healing. Joy DeGruy Publications Inc., 2005. Hobson, J. M., M. D. Moody, R. E. Sorge, and B. R. Goodin. "The Neurobiology of Social Stress Resulting from Racism." Social Cognitive and Affective Neuroscience, vol. 17, no. 2, 2022, pp. 181–191. Hicken, Margaret T., et al. "Everyday Discrimination, Chronic Stress, and Cardiovascular Health." American Journal of Epidemiology, 2014. Geronimus, Arline T. "Weathering and the Health of African-American Women." Ethnicity & Disease, 2006. Menakem, Resmaa. My Grandmother's Hands: Racialized Trauma and the Pathway to Mending Our Hearts and Bodies. Central Recovery Press, 2017. Okun, Tema. "White Supremacy Culture." Dismantling Racism Works, originally published 1999, revised 2021. Williams, Monnica T. "Racial Trauma: Theory, Research, and Healing." American Psychologist, vol. 74, no. 1, 2019, pp. 33–42.  

Mood swings, irritability, anxiety, and emotional reactivity are common symptoms many women experience during chronic stress and hormonal shifts in midlife. These patterns are often linked to cortisol imbalance and disruption in the body's stress response system.In this episode, Janell explains the cortisol cascade — a stress pattern that develops when the nervous system stays in a prolonged fight-or-flight state. Over time, chronic stress can disrupt the HPA axis, alter hormone signaling, destabilize blood sugar, and affect the hormones that support emotional regulation and restorative sleep.Many women notice that they feel more reactive than they used to. Small things trigger irritation. Emotional bandwidth feels narrower. Energy fluctuates throughout the day. These experiences are often misunderstood as mood issues, when in reality they can be rooted in chronic stress physiology.Janell walks through how cortisol interacts with progesterone, why the body prioritizes survival over hormone balance during prolonged stress, and how modern life continuously activates the stress response in ways our nervous systems were never designed to handle.This conversation helps reframe mood swings through a physiological lens so women can begin understanding the patterns behind what they are experiencing.In This Episode You'll Learn• What the HPA axis is and why it plays a central role in stress and hormone regulation• Why chronic stress can create mood swings, irritability, and emotional reactivity• The difference between high cortisol and low cortisol patterns• How the body shifts hormone production during prolonged stress• Why cortisol can contribute to progesterone imbalance in midlife• How stress and blood sugar instability reinforce each other• Simple daily shifts that help regulate the nervous system and support healthier cortisol rhythmsMentioned in This EpisodeTake the Hormone Clarity Quiz to better understand which physiological pattern may be affecting your energy, mood, and hormones right now.Connect with JanellInstagramhttp://instagram.com/thetransformationlifeListen to the full show:Apple Podcastshttps://podcasts.apple.com/us/podcast/the-transformation-show/id1441665376?uo=4Spotifyhttps://open.spotify.com/show/3aWZqptF6dne2sZLPbJdkY

In this episode of Hope Natural Health, Dr. Erin connects with Dr. Desiree Caruso, a Naturopathic Doctor and advisor with AIO Wellness. Dr. Desiree shares her fascinating journey of becoming a "mushroom nerd" and how these ancient fungi serve as modern tools for biohacking. They dive deep into the science of how high-quality, dual-extracted mushrooms help women shift out of "survival mode" to reclaim their energy, focus, and hormonal balance through purity, transparency, and functional formulations. During this episode you will learn about: How functional mushrooms act as true adaptogens, helping the HPA axis recalibrate so your body can prioritize hormone production over chronic survival stress. Why Cordyceps is the ultimate "quick win" for the exhausted-but-wired woman, increasing ATP (cellular energy) without the jitters or crashes associated with caffeine. How dual-extraction allows specific compounds to cross the blood-brain barrier to repair nerve cells, enhance memory, and clear "chemo brain" or perimenopausal fog. The "gold standard" mushroom for supporting insulin sensitivity and promoting healthy ovulation, making it a powerful ally for reproductive health. Why mushroom polysaccharides are essential for producing butyrate the "guardian of the colon" which maintains barrier integrity and supports estrogen recycling. Why choosing USDA organic, wood-grown fruiting bodies over "ground-up rice" is the difference between a therapeutic result and a wasted supplement.   Exclusive Offer for Listeners: Apply code DRERIN at checkout to save on your order of organic, dual-extracted mushroom blends and capsules. https://www.eversiowellness.com/discount/DRERIN?redirect=%2Fcollections%2Fall-products Website: www.eversiowellness.com Follow on Social Media:  Instagram: @eversiowellness @drdesireecaruso For more on Dr. Erin: Join The Hope Circle Community: https://hormonehealingproject.drerinellis.com/communities/groups/the-hope-circle/home?invite=69120d498b7e3f60397656b8 Work with Dr. Erin here: https://p.bttr.to/3E88ps4 Buy Dr. Erin's Supplements here: https://drerinellis.com/shop Get the Period Productivity Planner here: https://www.amazon.com/dp/B0BBYBRT5Q?ref_=pe_3052080_397514860 Download the FREE Menstrual Cycle Nutrition Guide here: https://detox.drerinellis.com/ Watch The Free Video "7 Hormones Affecting Your Weight Loss Goals" here: https://weightloss.drerinellis.com/   Let's Be Friends: Follow Dr. Erin on Instagram: https://www.instagram.com/dr.erinellis/ Follow Dr. Erin on Facebook: https://www.facebook.com/drerinellisnmd Follow Dr. Erin on TikTok: https://www.tiktok.com/@dr.erinellis?lang=en Join the Free Hope Circle Community: https://hormonehealingproject.drerinellis.com/communities/groups/the-hope-circle/home?invite=69120d498b7e3f60397656b8  Bookmark Dr. Erin's Website: www.drerinellis.com Subscribe to Hope Natural Health on YouTube: https://www.youtube.com/channel/UChHYVmNEu5tKu91EATHhEiA Follow Hope Natural Health on FB: https://www.facebook.com/hopenaturalhealth Sign up for Newsletters here:   https://booking.hopenaturalhealth.com/widget/form/VUubL7MNYELduwQL8ssI

If you've changed your diet, taken the probiotics, followed the gut protocol, and you're still not fully well, this episode explains why. In part two of our gut-immunity series, we introduce the adrenal-gut-immune Triangle and the missing link that keeps so many people stuck: chronic stress and HPA axis dysfunction.02:12 – What the Adrenal System Actually Is (HPA Axis Explained)04:25 – HPA Axis Dysfunction: Hyperactivation vs Adrenal Fatigue06:28 – How Chronic Stress Damages the Gut08:14 – What Chronic Cortisol Does to the Immune System10:50 – The Self-Reinforcing Stress–Gut–Inflammation Loop11:40 – Identifying Your Dominant Pattern: Adrenal, Gut or Immune?14:38 – What Working With the Triangle Actually Looks Like (3 Core Priorities)20:40 – Why Addressing All Three Systems Creates Durable ResultsIf you've ever said, “I've tried everything,” this episode will help you see what's been missing and what to do next.RESOURCES: Grab all the links and resources mentioned in this episode at https://www.nicolegoodehealth.com/the-goode-health-podcast/episode-116DISCLAIMER: The content in this podcast and related website is not intended to be a substitute for medical advice. It is not intended to be used to diagnose or treat, instead it is designed to help educate and inspire. Always seek the advice of a professional medical practitioner or qualified health practitioner. Never ignore or disregard advice given to you based on information in this podcast or related website and do not delay in seeking medical advice.

Is perimenopause a hormonal breakdown or a redirection of power?In this episode, we sit down with naturopath and feminine wisdom teacher Brenda Rogers to reframe menopause through a neuroadrenal lens. Rather than chasing fluctuating sex hormones, we explore what truly moves the needle in clinic: stabilising the nervous system, anchoring blood sugar, restoring sleep depth, and helping women discern what is normal in midlife change. Brenda shares the lived journey behind her book Dragon Time and why clarity, not correction, is often the most therapeutic intervention.Across the conversation, we unpack the leadership emergence of the post-reproductive woman and the cultural blind spots that amplify anxiety, low mood, and self-doubt. You will hear how the “oestrogen veil” thinning can heighten both sensitivity and intuition, why protein-first nutrition and healthy fats calm the brain, and how minerals such as magnesium and calcium support muscular ease and deeper sleep. We also clarify practical testing priorities including fasting glucose, thyroid markers, and inflammatory indicators, while avoiding the common trap of overvaluing sex hormone panels that rarely change clinical direction during perimenopause.Therapeutically, we explore herbs that meet real-life demands: saffron to modulate neuroinflammation and steady mood, kava for muscular tension and focused calm, and Withania to support HPA axis resilience. Brenda reminds us that small, consistent dietary shifts and personalised herbal prescribing outperform supplement sprawl, and that conversations about grief, boundaries, courage, and meaning are as clinically relevant as any lab result.This episode offers a blueprint for transforming hot flushes, fractured sleep, and overwhelm into steadiness, clarity, and renewed purpose.If you are ready to stop pushing through and start directing energy towards what matters most, this is a conversation to share with your patients and your peers.Subscribe, share with a colleague who needs a reframe, and leave a review to tell us what you will stop giving your energy to this season.Connect with Brenda: www.brendarogers.com.auShownotes and references are available on the Designs for Health websiteRegister as a Designs for Health Practitioner and discover quality practitioner- only supplements at www.designsforhealth.com.au Follow us on Socials Instagram: Designsforhealthaus Facebook: Designsforhealthaus DISCLAIMER: The Information provided in the Wellness by Designs podcast is for educational purposes only; the information presented is not intended to be used as medical advice; please seek the advice of a qualified healthcare professional if what you have heard here today raises questions or concerns relating to your health

What if inflammation isn't the enemy? For decades we've been told to suppress it, silence it, and eliminate it as quickly as possible. Anti-inflammatory diets. Anti-inflammatory drugs. Anti-inflammatory supplements. But what if the body is doing exactly what it's supposed to do? In this powerful solo episode, Darin breaks down the biology of inflammation and challenges the modern narrative that inflammation itself is the disease. Instead, he reveals a deeper truth: inflammation is a signal — an intelligent response to disruption in the body's environment. From gut health and modern diet to stress, sleep deprivation, environmental toxins, and movement deprivation, this episode uncovers the real drivers behind chronic inflammation and why suppressing the signal without addressing the cause may actually delay healing. This isn't about rejecting modern medicine. It's about asking a better question. Why is the fire there in the first place?     In This Episode Why inflammation is the body's emergency response system The difference between acute inflammation and chronic inflammation The chemical cascade that activates the immune response How the body naturally turns inflammation off through resolution molecules Why chronic inflammation is often a signal that the trigger hasn't been removed The gut microbiome and the connection between leaky gut and systemic inflammation Why Western diets dramatically alter inflammatory signaling The omega-6 to omega-3 imbalance in modern food systems How refined sugar activates inflammatory pathways in the body Chronic psychological stress and the HPA axis inflammatory response The gut-brain-inflammation connection and mental health Sleep disruption and the immune-sleep "crosstalk" cycle Why skeletal muscle acts as an anti-inflammatory organ Environmental toxins, PFAS, pesticides, and microplastics as immune triggers What ancient systems like Ayurveda and Traditional Chinese Medicine understood about inflammation thousands of years ago The global reliance on NSAIDs and the culture of suppressing symptoms Research showing anti-inflammatory drugs may delay healing The cycle of gut damage and chronic inflammation created by long-term NSAID use Why removing triggers is the real path to resolving inflammation     Chapters 00:00:03 – Opening: Welcome to SuperLife and the mission of building health sovereignty 00:00:33 – Sponsor: Manna 00:02:16 – Introducing the topic: Why inflammation may be widely misunderstood 00:03:00 – The modern obsession with "anti-inflammatory everything" 00:04:14 – Reframing inflammation: the body's emergency response system 00:05:30 – What actually happens inside the body during inflammation 00:07:00 – Breakthrough research on the body's natural inflammation resolution system 00:08:01 – Acute inflammation vs chronic inflammation explained 00:09:14 – Chronic inflammation and its link to major diseases 00:09:45 – Why inflammation is often a symptom rather than the root cause 00:10:40 – The gut microbiome and its role in regulating inflammation 00:11:40 – How ultra-processed foods damage the gut and trigger inflammatory signals 00:12:23 – Sponsor: Our Place 00:14:53 – Omega-3 vs omega-6 fats and their influence on inflammatory pathways 00:15:48 – Sugar, insulin signaling, and metabolic inflammation 00:16:09 – Chronic stress and the inflammatory cascade 00:17:06 – The gut-brain-inflammation connection 00:18:00 – Sleep and the body's nightly inflammatory reset 00:18:31 – Muscle contraction and the release of anti-inflammatory myokines 00:19:16 – Environmental toxins and why the immune system responds with inflammation 00:20:04 – Ancient perspectives on inflammation, including Ayurveda's concept of "Pitta" 00:22:48 – The widespread use of NSAIDs and anti-inflammatory medications 00:23:50 – Research showing suppressing inflammation may delay healing 00:25:05 – The vicious cycle of NSAIDs damaging the gut and increasing inflammation 00:26:15 – Dietary patterns that reduce inflammatory triggers 00:27:18 – Why daily movement acts as natural anti-inflammatory medicine 00:27:50 – A better question to ask your doctor: Why is inflammation present? 00:28:09 – The final perspective: inflammation as communication from the body 00:29:07 – Closing message: inflammation is not the enemy: it's the conversation     Thank You to Our Sponsors Our Place – Non-toxic cookware that keeps harmful chemicals out of your food. Get 10% off at fromourplace.com with code DARIN. Manna Vitality: Go to mannavitality.com/ and use code DARIN12 for 12% off your order.       Join the SuperLife Community Get Darin's deeper wellness breakdowns — beyond social media restrictions: Weekly voice notes Ingredient deep dives Wellness challenges Energy + consciousness tools Community accountability Extended episodes Join for $7.49/month → https://patreon.com/darinolien       Find More from Darin Olien: Instagram: @darinolien Podcast: SuperLife Podcast Website: superlife.com Book: Fatal Conveniences     Key Takeaway Inflammation is not a malfunction. It is your body raising the alarm: responding to stress, toxins, injury, imbalance, and disruption. Suppressing the alarm without asking why it's ringing keeps the cycle going. Healing begins when we stop fighting the signal and start listening to what the body is trying to tell us. Your body isn't broken. It's responding to the environment it's been given. Change the environment and the biology follows.  

“The brewpub model has proven itself to be the right model over the last few years.”Few people have been through as eventful a few years as Dave Padden. The founder of Akasha Brewing spearheaded a successful crowdfunding campaign in 2022 which enabled the acquisition of two new venues, only for one of them to later close overnight, followed by a period in voluntary administration, and a subsequent merger with fellow Sydney operation Wayward.Soon afterwards, both businesses were acquired by the Powder Monkey Group, a UK-based operation whose Australian wing, headed by Southern Highlands Brewing founder Ben Twomey, now owns all of the above plus Willie the Boatman.Confused? You've every reason to be, but help is at hand.Dave is now the GM for Powder Monkey Australia, so we joined him at the soon-to-open Powder Monkey brewpub in Camden to find out how the brands are working together within the group, as well as what its founders' goals are – both here and overseas.We also trace his time in the beer industry, from the pioneering 77 and 777 IPAs he created at his first brewery, Riverside, to the recent roller-coaster at Akasha. And we explore his approach to brewing while seeking his thoughts on the state of the wider industry.There was plenty for Will and James to discuss in this week's intro too: the launch of HPA's new hop Luna; Cheeky Monkey's plans for a fourth venue; Loam and Voyager's success at the 2026 Malt Cup; the launch of the Cross Keys Hotel in Newcastle; and Stoic's acquisition of Bass Point Brewing in Shellharbour.In fact, so much has happened in the week since our last show that we even forgot to talk about the launch of the lineup for our very own festival, Pint of Origin… Speaking of festivals, look out for a High Country Hop Technical Symposium preview with festival founder Ben Kraus midway through the show.Start of segments: 0:00 – Intro 18:55 – Dave Padden Part 1 38:50 – The High Country Hop Technical Symposium 42:16 – Dave Padden Part 2To find out more about featuring on The Crafty Pint Podcast or otherwise partnering with The Crafty Pint, contact craig@craftypint.com.

Dr. Deb Muth 0:00 Welcome back to Let’s Talk Wellness Now. I’m your host, Dr. Zab, and we are continuing our discussion this week on 0:08 peptides. And so, if you haven’t heard our first conversation about peptides, 0:13 please go back and look at that episode. We talk all about the manufacturing, the safety, the quality of peptides, and we 0:20 dove into GLP1s. And today we’re going to dive into peptides for sexual 0:26 wellness, immune function, growth hormone, and all the amazing fun things 0:32 we can do with peptides. So, as usual, grab your cup of coffee or tea, settle 0:37 in, and let’s talk wellness now. And we’re going to take a short pause from our sponsor. I know we’ve got to do 0:44 that, you guys. They’re who keep us on the air. So, I’m going to pause for just a minute and be right back after this 0:50 message from our sponsor. Ladies, it’s time to reignite your vitality. Primal 0:56 Queen supplements are clean, powerful formulas made for women like you who want balance, strength, and energy that 1:03 lasts. Get 25% off at primal queen.com. Serenity Health. That’s primalqueen.com. 1:10 Serenity Health. Because every queen deserves to feel in her prime. All 1:15 right, everybody. We are back. And are you ready? We are talking all things peptide and I am opening the show today 1:23 with sexual wellness. Yes, I’m going there, you guys. I am going there. You 1:29 know, this has really become a big issue for people um of all ages. It’s not just 1:3 4us older people. It’s younger people, too. And there’s a whole variety of reasons why we have sexual dysfunction. 1:42 And when we’re talking about sexual dysfunction, we’re not just talking about it doesn’t work, right? Or I can’t 1:48 reach orgasm. A lot of it is around desire and um the thought of it and 1:54 wanting to connect, wanting to be kinder to one another, wanting to be touching 2:00 one another. A lot of it resolves or revolves around that. And so there are some peptides that can help us and I’m 2:08 really excited to be able to talk about those today. So the first one is called PT-141. 2:14 This targets the brain not the periphery. Right? So for many women I 2:20 will always tell you sex starts between here. It is a brain thing for us. It is 2:26 not necessarily a physical thing. For guys that’s a little different. It’s very physical. For women it’s all in our 2:32 brain. So tip for you men that are listening. You have to prime your woman’s brain first if you want her to 2:38 have sex with you that night. You have to be nice to her. You have to bring her flowers. Do the dishes for her. Do 2:45 something kind. Bring her a cup of coffee or tea or a glass of wine. Take her to dinner. You have to woo her. And 2:51 I don’t care how long you’ve been married. That has to happen. And tip number two, don’t say anything stupid 2:57 that day. I’m just being honest. When you guys say things that make us upset, 3:03 that lingers with us for the rest of the day. And it’s it’s a turnoff for us. And 3:08 for a lot of women, we can’t get past that when it comes time to snuggle at night. And sex doesn’t always have to be 3:14 at night either. So, you can tell I really love talking about this conversation, but we’re going to get into the peptide part of it because this 3:21 is going to help people. So, um, PT-141 is marketed as I’m going to slaughter 3:28 this name, Vali, and it represents a fundamentally different approach to 3:34 sexual dysfunction than the PDE5s inhibitors like Slenden, Viagra, 3:40 Tedataphil, which is Seialis. And while the PDE5 inhibitors work specifically by 3:47 enhancing blood flow to the genital tissues, PT-141 works centrally in the brain by 3:54 modulating neural s neural circuits involved in the sexual desire and 4:00 arousal. Now PT-41 is a cyclic hpatipeptide. It’s seven amino acid 4:07 peptide arranged in a cyclic structure that acts as a melanoortin receptor 4:13 agonist and with particularly the infinity for MC3R and MC4R subtypes. 4:20 It’s actually a metabolite of the melanotan 2, a peptide originally 4:26 developed for tanning that was also found to enhance sexual desire in early 4:31 studies. Now the melanoortin system in the brain is involved in multiple functions including energy homeostasis 4:39 but it also is involved in sexual motivation and arousal behaviors. The FDA approved PT-141 in 2019 specifically 4:48 for the treatment of acquired generalized hypoactive sexual desire 4:54 HSDD in permenopausal women. So for the first time we have a medication that was 5:01 approved by the FDA to use for women for sexual dysfunction. We have had all of 5:07 these seialis tedataphil viagros for men but we had nothing for women. And so 5:12 this is amazing that this is available for women and approved by the FDA. It’s a big deal. This represents the first 5:19 and only FDA approved medication specifically targeting these circuits of sexual desire rather than the peripheral 5:27 arousal mechanisms. And this indication is quite specific, meaning it was developed at some point, not lifelong. 5:35 So I if you’ve had sexual dysfunction your entire life, this medication was 5:40 not approved for you. But if it’s something that you developed over time, like when you went through pmenopause or 5:46 menopause or some women have this experience happen after childirth, that’s what we’re talking about here. 5:53 Now, it’s also not just um supposed to be used if you dislike your partner, 5:59 right? If your relationship is bad and you dislike your partner, this probably isn’t going to fix a ton. It might help 6:05 a little bit, but that’s not what it’s meant for. So, you really have to know what you’re using it for and why. And 6:11 the other thing that I would say is this is something that we don’t go to if your hormones are not balanced properly. You 6:17 have to balance your hormones properly before using something like this because it still may not work. Now, the only 6:24 caveat to that is if you’re a woman that has a risk of breast cancer and can’t use hormones, then that’s a different 6:31 story and we would have that conversation about whether or not this medication would be appropriate for you. Now, the FDA label specifies PTA1 uh 6:39 PT-141 as it not being indicated for HSDD in causes where low sexual desire 6:46 is due to coexisting medical or psychiatric conditions, problems with relationships, like we had talked about, 6:53 side effects to medications or other substance use. This specifically reflects the importance of differential 6:59 diagnosis. Low sexual desire can have many root causes and PT-41 is only 7:05 appropriate when those causes have been ruled out. Now, I have I used PT41 in 7:10 people who have sexual dysfunction issues as a result of using 7:16 anti-depressants. Yes, I have. I’ve used Flynn in that effect as well. And it 7:21 does work sometimes, but it doesn’t work completely. But you need to know that that is not what the approval is for the 7:27 FDA. So that is done in something that we call off label use. So very important 7:33 to know. Now in these clinical trials leading to FDA approval, this was published by Kinsburg and colleagues in 7:40 obstetrics and gyne gynecology in 2019. PT-141 demonstrated statistically 7:46 significant improvements in sexual desire and decreases in distress related 7:51 to low desire compared to placebo. The effects manifest over 45 minutes to 7:56 several hours after the injection and the mechanisms involved modulation of dopamine and melanoorton pathways in the 8:04 hypothalamus and the brain regions that involved sexual motivation. Now cardiovascular effects of PT 141 require 8:12 careful attention. This drug causes transient increases in blood pressure about 3 to four points and transient 8:20 decreases in heart rate. And because of this, it is contraindicated in patients 8:25 with uncontrolled hypertension or known cardiovascular disease. And it has been studied in patients who’ve had recent 8:32 cardiovascular events or sorry hasn’t been studied hasn’t been studied in patients who’ve had recent 8:39 cardiovascular events. So patients need to have their blood pressures checked before starting therapy. Nausea is 8:45 extremely common. It is one of the biggest things I often will tell people to take an anti-nausea medicine if 8:52 they’re going to do this because the last thing you want to do is inject this medication and think it’s going to give 8:57 you this great time with your partner and you’re so nauseated that you can’t even perform, don’t want to kiss, don’t 9:05 want to do anything. It it can be pretty profound for some people. um it does affect about 40% of the patients in 9:12 clinical trials which is why many clinicians require or recommend an 9:17 anti-nausea medication like I had just said other common adverse effects include flushing injection site 9:24 reactions headache in about 13% of the population which I have seen worse if 9:30 people are prone to headaches and the headaches are pretty intense so I will also have them premedicate if they have 9:36 that um sensitivity ity with a Tylenol or Advil, Alie, whatever it is they 9:42 typically use for their headaches to help prevent that from occurring. Now, some patients also experience a 9:50 generalized hyperpigmentation of their skin, particularly in areas with chronic friction, and this may not be reversible 9:57 after discontinuation. So from an integrative perspective, PT-41 10:03 represents one tool in addressing female sexual dysfunction, but it should never be the first or only intervention. And 10:11 low sexual desire in women is complex. Multiffactorial involving hormonal imbalances, low testosterone, estrogen 10:18 deficiency, progesterone imbalances, thyroid dysfunction, adrenal dysfunction, and with elevated or 10:24 disregulated cortisol levels, sleep deprivation, relationship issues, unresolved trauma, including sexual 10:31 trauma, chronic pain, body image concerns, and medication side effects such as SSRIs are notorious for this. So 10:39 a comprehensive hormone panel including total and free testosterones, estradile, 10:45 progesterone, DHEA, thyroid function in cortisol assessment, ideally four-point 10:51 cortisol, salivary should precede any pharmacological intervention. And additionally, addressing the 10:57 psychological component and relationship dimensions through appropriate therapy is necessary. I have a lot of patients 11:03 that say, “This is just too much work for sex. I don’t want the side effects. I don’t want to deal with this.” and that’s totally fine. But for some 11:09 people, their sexual dysfunction is actually causing more problems on their 11:14 relationship and they want to do something to fix that. And just know that if you’re using a peptide like this 11:20 that comes with some of these side effects and you have to premedicate for it, it is not the end of the world. Um, 11:27 but it may be a possibility that you may need that. So, let’s dive into body composition and growth hormone access. 11:34 So Tesmarellin is the only FDA approved GH 11:40 analog. Tesarelin is marketed as Agrifta and Agria SV. It is a synthetic analog 11:48 of human growth hormone releasing hormone. So GH RH human growth hormone 11:53 releasing hormone. These things are such long names it’s confusing and it’s difficult to spit out, right? It 11:59 consists of 44 amino acids. The structure is identical to our own 12:05 body’s growth hormone GHR um with the addition of trans3 hexonol group which 12:14 stabilizes the molecule that extends its half-life compared to the native GHR. 12:19 The mechanism of tesmarellin is elegant in its preservation of physiological 12:24 growth hormone GH secretion patterns and rather than administering an exogenous 12:30 growth hormone directly, tesmarillin binds to the GH receptor in the anterior 12:36 pituitary gland stimulating the indogenous pulsatile release of GH. So 12:42 you know it it’s slower in that stimulation and it pulsates instead of a direct rise and fall. This pusile 12:49 pattern more closely mimics natural GH secretion which occurs in bursts 12:54 primarily during sleep. The GH then stimulates the liver to produce insulin-like growth factor IGF-1 which 13:01 exerts many of the downstream metabolic effects including lipolytic effects on 13:07 the atapost tissue. So fat atapose and how we break that down. The FDA approved 13:13 tesmarellin in 2010 for a very specific narrow indication, the reduction of 13:19 excess abdominal fat in HIV infected patients with lipodistrophe. This 13:25 condition characterized by abnormal fat redistribution with accumulation of visceral body fat and the loss of 13:32 subcutaneous fat in face and limbs developed as a complication of an 13:37 antiviral therapy particularly with older protease inhibitor reg uh 13:42 regimens. The visceral fat accumulation in patients is not just cosmetic. It’s associated with increased cardiovascular 13:49 risk, insulin resistance, and inflammatory markers. The pivotal trial that led to the FDA approval included 13:56 work by Stanley and colleagues published in the annuals of internal medicine in 2014. It demonstrated that tesmarillan 14:03 significantly reduced the visceral atapose measured by CT scan by approximately 15 to 20% which is a 14:10 significant difference to placebo over a short period of time only 26 weeks. Now, 14:16 interestingly, the total body uh weight typically remained stable or even 14:21 increased slightly as the reduction of visceral fat was sometimes offset by increases in lean body mass or 14:28 subcutaneous fat. This highlights an important point. Tesmearellin is not a weight loss drug in its conventional 14:34 sense. Its effects are specifically on body composition and fat redistribution. 14:40 Now the glucose metabolism effects of tesmarellin do require careful monitoring because GH and IGF1 can 14:47 induce insulin resistance. Tesmearellin can increase glucose levels and hemoglobin A1C and in these clinical 14:54 trials glucose tolerance and new onset diabetes occurred in some patients. So 14:59 this creates a therapeutic paradox while res reducing visceral fat we should theoretically improve metabolic health. 15:07 The GH mediated insulin resistance can worsen the glycemic control and patients 15:12 with diabetes require particularly close monitoring. The potential need for adjustment in diabetic medications can 15:19 occur. So I already know what you guys are thinking. Can I use Tesmarellin and 15:24 GLP1 at the same time? And the answer is yes. Especially in those people that we 15:30 know have an insulin resistance already or are prone to that, we can use lowd 15:36 dose micro doing GLP-1 along with tesmarellin to help prevent this from 15:42 occurring um or reduce the risk of it occurring. Now there are some other adverse related problems to growth 15:49 hormone access which include fluid retention which can uh manifest as uh 15:55 ankle swelling, joint pain, muscle pain, paristhesas, carpal tunnel syndrome is 16:01 common to see. Of course you can always see injection site reactions reported about 26 to 30% of the time in the trial 16:08 participants. And this also theoretically has a concern about IGF-1 elevation potentially promoting 16:14 malignancy through long-term data is limited. So we have to be cautious about 16:20 this but it is a growth hormone and anything that is a growth hormone can cause cells to grow and it cannot 16:26 necessarily differentiate between healthy cells and bad cells. So the drug is contraindicated is contraindicated in 16:33 patients with active cancer and in patients with the disruption of the HPA access from conditions like pituitary 16:40 tumors, pituitary surgery, head of radiation um and traumatic brain injury. 16:46 Now off label use of tesmarellin for general anti-aging or body composition 16:51 optimization in non-HIV population, it doesn’t have FDA approval. There is no 16:58 FDA studies. um that promote this, but practitioners do prescribe it for these 17:04 purposes under an experimental and not supported by FDA approved indications. 17:10 And um from an integrative medical standpoint, optimizing natural growth 17:15 hormone secretion through lifestyle interventions, high quality sleep is important. GH primarily is excreted 17:22 during sleep and deep sleep waves. So improving your deep sleep is important. Intermittent fasting can also increase 17:28 growth hormone by five-fold as demonstrated in a Hartman and colleagues uh study from the journal of clinical 17:35 endocrinology and metabolism in 1992. And highintensity interval training, adequate dietary protein, blood sugar 17:42 control, these all can help naturally increase your growth hormone. So, let’s 17:47 dive in now and talk about bone health. peptide hormones um such as oh I’m gonna 17:54 I’m gonna really slaughter this name. Terraparatide is a true bonebuilding 18:01 peptide. It’s marketed as forio. It’s a recumbent form of the first 34 amino 18:08 acids out of 85 of the human parathyroid hormone PTH. It represents a unique 18:13 approach to osteoporosis treatment because it’s one of the few truly anabolic anabolic bone therapies meaning 18:21 it actively binds new bone rather than simply preventing bone loss. The biology 18:26 of parathyroid is fascinating and seemly contraindicated or uh contradictory. 18:32 Continuously sustained elevations of PTH as occurs in hyperarathyroidism 18:37 is catabolic to bone. So people who have hyperarothyroidism typically have significant bone loss 18:44 especially before it’s diagnosed and it causes causes increased bone 18:49 reabsorption loss of bone density increased fracture risk and however 18:55 intermittent exposure to PTH as achieved with once daily uh injections of forio 19:01 has the opposite effect. This intermittent exposure preferentially stimulates osteoblasts bone building 19:08 cells over osteoclasts bone reabsorbing cells and it leads to 19:13 the net bone formation. So terraparatide binds to the PTH receptors on 19:20 osteoblasts and renal tubular cells in bone. It increases the number of 19:25 activity of osteoblasts stimulating the differentiation of osteoblast precursor cells and may 19:32 reduce osteoblast apoptosis basically programmed cell death allowing this bone 19:37 building cell to work longer. The result is increased bone formation, improved bone architecture and tbacular 19:45 connectivity and ultimately increased bone mineral density um particularly in the hip and the spine which is so 19:51 difficult to regain. The FDA approved this medication in 2002 based on pivotal 19:57 studies by Near and colleagues published in the New England Journal of Medicine in 2001 which demonstrated significant 20:05 reductions in vertebral and non-vebral fractures in post-menopausal women with 20:11 osteoporosis. specifically uh reduced new vertebral fractures by 20:17 65% and nonvettebral fragility fractures by 53% 20:23 compared to placebo over a median followup of 21 months. This is really 20:29 incredible because we have not seen this kind of um change uh in other 20:35 medications that we’ve used for osteoporosis. So current FDA approval 20:40 indicates uh this for post-menopausal women with osteoporosis at high risk for 20:46 fracture, men with primary or hypoconatal osteoporosis at high risk for fracture 20:53 and men and women with glucocord cord glucocordide 21:00 induced osteoporosis at high risk for fracture. The high risk qualifier is 21:05 important. uh terrapeptide is reserved for patients with severe osteoporosis, 21:11 multiple fractures, very low low bone density and those who have failed or are 21:16 intolerant of other therapies. The most significant concern for this medication 21:21 is highlighted in a boxed warning with rat toxicology studies where it caused 21:27 osteioaroma which is a bone cancer in a dose dependent and treatment duration dependent manner. The revolence of this 21:34 finding to humans is debated. Rats have fundamentally different bone biology than humans with continuous bone growth 21:41 throughout life and different PTH receptors. Now post marketing 21:46 surveillance in humans hasn’t shown a clear increase in osteocaroma risk but 21:51 theoretically concerns persist and because of this terapeptide is 21:57 contraindicated in patients at risk baseline risk for osteioaroma 22:02 including those with pageantss disease of the bone unexplained elevations of alkaline phosphate prior skeletal 22:10 radiations bone metastases or skeletal malignancies and pediatric patients or young adults 22:16 with open hyes. There’s also a lifetime treatment duration of only 2 years and 22:22 terrapeptide can cause transient hypercalcemia. So an elevated blood calcium and as PTH normally increases 22:31 calcium levels by enhancing bone reabsorption, increasing renal calcium 22:36 reabsorption and promoting activation of vitamin D which increases intestinal calcium absorption. Some patients 22:43 experience orthostatic hypotension within 4 hours of injecting requiring 22:48 caution in at risk populations for blood pressure. Common side effects include 22:53 muscle pain, joint pain, pain in the limbs, nausea, headache, and dizziness. So from an integrative bone health 23:00 perspective, terrapeptides should be part of a comprehensive strategy. Adequate calcium intake, 500 to a,000 23:08 milligrams of calcium a day from food and supplements combined. and vitamin D. 23:13 Getting vitamin D levels of at least 50 to 80 are essential for the drug to work 23:20 optimally. But beyond this, bone health requires vitamin K2, which directs calcium into the bones rather than soft 23:27 tissues, magnesium as a co-actor in bone metabolism, trace minerals like boron, 23:33 copper, silica, and of course, adequate protein intake, which many of us, especially as women, don’t do 0.8 8 to 1 23:42 gram of protein per kilogram of body weight, weightbearing exercise. Of 23:47 course, these all provide mechanical signals that complement the biochemical 23:52 symbol uh signals of terrapeptide. Sequential therapy is also critical. The 23:58 bone mass gains from terraparatide can be lost if patients don’t transition to 24:05 an anti-resorbbitive agent a bisphosphinate after completing this therapy and the anabolic effects to 24:12 build bone but maintaining the new bone requires preventing excess reabsorption. 24:18 So positive things about this but there are definitely some concerns as well. So 24:23 the next one we’re going to talk about is Lu Prolrooide. It is marketed under 24:29 the multiple brand names of Lupron, Depo, Eligard, and it’s a synthetic 24:34 nonapeptide analog of naturally occurring ginonadotropen releasing 24:39 hormone G&R, also called luteinizing hormone releasing hormone, LHR. 24:46 It’s a fascinating example of how manipulating natural hormonal feedback systems can create therapeutic effects. 24:53 So, G&RH is normally secreted in a pulsatile fashion by the hypothalamus 24:59 and travels to the anterior pituitary where it binds to G&R receptors and 25:05 stimulates the release of luteinizing hormone LH and follical stimulating hormone FSH. These ginatotropins signal 25:13 the ovaries or the testes to produce sex hormones, estrogen, progesterone in 25:18 women, testosterone in men. Uh, luoprololi lupron as a GNR agonist 25:26 initially mimics the action of natural G&R causing an acute flare response with 25:33 uh increased LHFSH secretion which temporarily increases sex hormone 25:38 production. However, the continuous administration which is in the depo 25:44 formulations, the GNR receptors in the pituitary become desensitized and 25:50 downregulated. And after about 2 to four weeks of continuous exposure, LH and FSH 25:56 secretion is profoundly suppressed, leading to what’s termed as chemical 26:01 castration. Testosterone levels in men drop to castrated levels less than 50 26:08 and estrogen production is marketkedly suppressed in women. This bifphasic 26:13 response creates both therapeutic applications and management challenges in prostate cancer where tumor growth is 26:20 typically androgen dependent and the ultimate goal is testosterone suppression. However, the initial 26:27 testosterone surge during the flare phase can temporarily worsen symptoms potentially causing increased bone pain, 26:34 urinary obstruction, or even spinal cord compression in patients with metastatic 26:40 disease. This is why uh luoprolide is often started with an anti-ad androgen 26:47 like bicladamide for the first two to four weeks to block the effects of the 26:52 testosterone surge. The FDA has approved lupalide for multiple indications across 26:59 formulations. In oncology, it’s used for palletive treatment of advanced prostate cancers. In gynecology, various 27:06 formulations are approved for endometriosis, for pain management and lesion reduction and for fibroids. 27:13 Typically for pre-operative uh hematological improvement in anemic patients. In pediatrics, it’s used for 27:20 central precocious p puberty basically to halt the premature sexual development of these young people. Now, there are 27:28 adex uh adverse effect profile that reflects profound hormonal suppression. 27:34 In men treated for prostate cancer, hot flashes affect about 59% of the patients. Other common effects include 27:41 general pain, swelling, bone pain. Um long-term use of these medications leads 27:47 to metabolic changes. It increases fat mass. It decreases lean mass. It worsens 27:53 insulin sensitivity, disrupts the cholesterol uh lipid panels, increases 27:59 diabetic risk, has some concerns over cardiovascular disease. And the metaanalysis have shown increased risks 28:06 of heart infarction, myocardial inffection, sudden cardiac death, and stroke in populations receiving 28:13 long-term androgen deprivation therapy. The bone effects are particularly dramatic. Without sex hormones, bone 28:20 density decreases significantly, typically 3 to 4% per year during the 28:26 first two to three years of therapy. And this bone loss may not fully be reversible after the the therapy 28:32 discontinues. The American Society of Clinical Oncology recommends bone density monitoring and consideration of 28:39 bisphosphinates uh in men receiving long-term androgen deprivation. In women treated for 28:46 endometriosis or fibroids, the estrogen suppression creates a hypoestrogenetic state similar 28:54 to menopause. Hot flashes affect 90% of patients with other common effects 29:00 including headaches, emotional irritability, decreased sex drive, vaginal dryness, bone density loss. And 29:08 because of these bone concerns and treatment duration with endometriosis, typically limited to six months, though 29:14 some formulations allow for longer use with adback hormonal therapy to 29:20 partially mitigate these side effects. The mood and cognitive effects can be s 29:25 significant. I’ve seen it over the years. the depression, the memory impairment, difficulty focusing and 29:31 concentrating. It can be very very traumatic and the quality of life that 29:37 happens for these uh women and men can be unbearing for many of them. Um, from 29:44 an integrative perspective, patients receiving this medication need comprehensive support care. Bone health 29:51 interventions using calcium, vitamin D, vitamin K2, weightbearing exercise, 29:58 cardiovascular risk management becomes critical, including blood pressure monitoring, lipid management, diabetes 30:05 screening. For hot flashes management, some patients respond to black coohos, 30:10 sage, or vitamin E. Though evidence is mixed and individual response varies, 30:16 omega-3s may help with the mood and the inflammation, resistance training becomes specifically important to 30:22 preserve lean muscle mass in the face of hormonal suppression. 30:27 Now there’s something called calcetonin salamon which is marketed as miaelin. 30:34 It is a nasal spray. It is now discontinued. And foral is the new 30:39 synthetic polyeptide hormone of 32 amino acids identical to calcetonin of salamon 30:47 origin. It represents an interesting case study in how initial promise gives 30:52 way to safety concerns that regulate a therapy to historical footnote status. 30:58 Calcetonin is naturally occurring hormone in humans. It’s secreted by the paraphalicular sea cells in the thyroid 31:04 gland. Its primary physiological role is to lower blood calcium levels by 31:10 directly inhibiting osteoclast activity, reducing bone reabsorption, increasing 31:16 renal calcium secretion or excretion, and possibly reducing the intestinal 31:21 calcium absorption. So, salamon calcetonin is used therapeutically because it’s more potent and longer 31:27 acting than human calcetonin. The FDA initially approved calceton and salmon 31:34 for several indications post-menopausal osteoporosis in women more than five 31:39 years post-menopausal when alternative treatments are not sustainable. Padet’s 31:44 disease for bone and hypercalcemium as emergency treatments. The nasal spray formulation is particularly popular for 31:53 osteoporosis because it offered a non-injectable alternative to bisphosphinates. 31:58 However, in 2012, the European Medicine’s Agency, EMA, conducted a 32:05 comprehensive safety safety review after a poolled analysis of 21 clinical trials 32:10 involving over 10,000 patients showed a statistically significant increase in 32:15 malignancy risk in patients treated with calceton salamon compared to compared to 32:21 placebo. The overall malignancy rate was 4.1% in calcetonin treated patients 32:28 versus 2.9% in placebo patients. The types of cancer 32:34 varied with no single cancer type predominating, making it difficult to establish a clear mechanistic link. 32:41 However, the signal was concerning enough that the EMA restricted the use of calcetonin containing medicines. In 32:48 the United States, the FDA issued communications about malignancy signal and conducted its own review. While they 32:56 didn’t fully withdraw the drug, the cons consensus shifted dramatically. The nasal spray formulations miaelson was 33:03 voluntarily discontinued by the manufacturer and current clinical practice guidelines now consider 33:10 calcetonin salamon as a second line or lower option for osteoporosis. While 33:15 behind bisphosphinates, dennism mob, uh, terrapeptide, the analesic effect of 33:21 calcetonin in bone pain, particularly in acute vitibbral, uh, compression 33:26 fractions from osteoporosis or pageantss disease may still provide a role for short-term use in these selected 33:32 patients. The mechanism of this pain relief is unclear, but may involve 33:38 effects of endorphin systems and/or direct actions on pathways. The history serves as an important reminder in 33:45 peptide medicine. Initial approval and early clinical use does not guarantee 33:50 long-term safety effects. Post marketing surveillance and poolled analysis of the clinical trial data can reveal adverse 33:58 effects that weren’t apparent in initial studies. It also underscores why newer 34:04 agents with better safety profiles um have largely replaced calcetonin in 34:10 clinical practice. So this is really an important thing. Not one thing stays the same forever. We have to change as we 34:18 identify new and better products as we identify problems and concerns. I will 34:24 always tell my patients if you are uncertain of taking a new drug which we 34:30 all should be wait five years. Within five years we are going to find the 34:36 problems that they didn’t find in the clinical studies. Remember, a lot of these clinical studies are small, small 34:43 groups, short periods of time. It’s expensive to do these trials. So, if you 34:49 wait for five years, in the first two to three years, you will see the problem start to emerge. And what are you going 34:55 to look for? You’re going to look for the the news um commercials from lawyers 35:02 suing a drug. And they will tell you what the problem is. and then you can decide, is this something that I want to 35:09 use or not. Don’t jump on bandwagon and be the first one to do this, especially 35:14 if you’re sensitive. You know, give it time so you can see exactly what’s going on. So, I’m going to end our show on 35:22 this and we are going to pick up on part three of peptide therapy in our next 35:28 segment where we’re going to talk about the investigational peptides and some 35:34 exciting things that are happening with that. So, I want to thank you for joining me today on Let’s Talk Wellness 35:39 Now. It’s always a pleasure having a conversation with you guys and I hope this brings value to you with what we’re 35:45 talking about. If you have ideas for topics that you want me to discuss, 35:51 please message us, you can share your comments on Facebook, you can email us, 35:58 um you can get a hold of us however you would like to share that. I do look at the comments below in the episodes as 36:04 well. So you can place your comments there. And once again, one of the best things you can do for me is like, 36:11 subscribe, and share so that we can spread the messages of what we’re doing. 36:16 I do this at no cost. I don’t make any money out of this. I do this as an 36:21 educational purpose for everybody else. I love doing it, but it really helps us 36:28 on the algorithms if you would be just willing to like, subscribe, and share. 36:33 So, thank you for spending your time with me. I know time is important.The post Episode 257 – Peptides for Sexual Wellness & Hormonal Health: PT-141, Growth Hormones, Bone Health & More! first appeared on Let's Talk Wellness Now.

In this exclusive series - The New Hop Order, presented by HPA - The Crafty Pint Podcast explores what's happening on the cutting edge of hop innovation from breeding and processing to brewing. In this episode, we're celebrating the launch of Luna®, a new flavour hop from HPA's powerhouse breeding program, tracking its fascinating 20-plus year journey to commercialisation with HPA's Head of Breeding & Research Dr Simon Whittock. We also talk with Bright Brewery's Operations Manager Lewis Kerr, for his insights on the new hop.

In this episode of the IRH Clinician's Corner, host Margaret Floyd Barry welcomes special guest Devin Delaney—a faculty member at the Institute of Restorative Health, former NCAA All-American and professional ski racer, and expert in working with high-performance women and athletes. We explore the unique clinical complexities of working with athlete clients, including the all-too-common normalization of discomfort, metabolic masking, and the misconceptions around performance and health.   In this interview, we discuss:   The normalization of symptoms in athletes and clinicians Clinical challenges in working with athletes Key areas for supporting athletes (e.g., blood sugar, gut health, inflammation & recovery) Clinical processes for working with athlete clients Supporting behavior change and motivation in athletes Mindset, joy, and the "why" behind athletics To read Devin's blog article "Five Clinical Considerations When Working with Athletes," click here: https://instituteofrestorativehealth.com/five-clinical-considerations-when-working-with-athletes/ For access to Devin's "Clinical Starting Point for Athletes" Handout, click here: https://discover.instituteofrestorativehealth.com/athlete-clinical-starting-point-framework The Clinician's Corner is brought to you by the Institute of Restorative Health. Follow us: https://www.instagram.com/instituteofrestorativehealth/   Connect with Devin Delaney: Website: https://www.peakathleat.com/ IG: https://www.instagram.com/devinsdelaney/ LinkedIn: https://www.linkedin.com/in/devin-delaney-44a34777/   Timestamps:  00:00 "Devin: Nutrition for High-Performing Athletes" 03:40 Burnout and Pursuing Balance 07:09 Healing Through Nutrition and Teaching 10:50 "Understanding and Supporting Athlete Stressors" 14:08 "Metabolic Masking and Nuance" 19:10 "Fueling Lessons from Ultra Running" 22:14 Athlete Gut Health and Stress 25:45 Signs of Overtraining and Depletion 28:36 "Recovery Metrics and Training Adaptation" 32:09 "Master Clinical Health Strategies" 33:08 "Overcoming Plant-Based Diet Challenges" 36:30 Motivated Athletes Embrace Change 41:21 "Enhancing Health with Genetic Testing" 43:12 Optimizing Athletes' Health and Performance 47:04 "Resources for Supporting Athletes" Speaker bio:  Devin Delaney is a Functional Nutritional Therapy Practitioner (FNTP) and Master Restorative Health Practitioner (Master RHP) dedicated to helping high-achieving women finally get to the root of frustrating health issues like bloating, fatigue, hormone imbalance, and digestive distress—so they can ditch discomfort, beat burnout, and reclaim a body that feels energized, capable, and truly at Peak health.   Based in Teton Valley, Idaho, Devin founded Peak AthlEAT Nutrition—a thriving virtual practice that blends functional lab testing, whole-food nutrition, and deeply personalized care to restore health from the inside out. Her work is guided by a core belief: symptoms aren't just something to manage, but vital messengers pointing the way toward true healing.   Keywords:  functional health practitioners, clinical skills, chronic disease reversal, athlete clients, gut dysfunction, hormone imbalance, fatigue, functional nutrition, lab interpretation, Peak Athlete Nutrition, clinical strategy, digestive health, blood sugar regulation, inflammation, nutrient deficiencies, HPA axis health, metabolic masking, symptom normalization, performance optimization, sports nutrition, overtraining, recovery metrics, lab testing, disordered eating, energy crashes, menstrual cycle issues, high-performance women, root cause analysis, sleep and recovery, individualized protocols Disclaimer: The views expressed in the IRH Clinician's Corner series are those of the individual speakers and interviewees, and do not necessarily reflect the views of the Institute of Restorative Health, LLC. The Institute of Restorative Health, LLC does not specifically endorse or approve of any of the information or opinions expressed in the IRH Clinician's Corner series. The information and opinions expressed in the IRH Clinician's Corner series are for educational purposes only and should not be construed as medical advice. If you have any medical concerns, please consult with a qualified healthcare professional. The Institute of Restorative Health, LLC is not liable for any damages or injuries that may result from the use of the information or opinions expressed in the IRH Clinician's Corner series. By viewing or listening to this information, you agree to hold the Institute of Restorative Health, LLC harmless from any and all claims, demands, and causes of action arising out of or in connection with your participation. Thank you for your understanding.  

On entend partout que le stress ferait “prendre du ventre”. Mythe des réseaux sociaux ou réalité scientifique ? La réponse est plus nuancée qu'un simple oui ou non.Quand le stress devient chronique, l'organisme active davantage l'axe HPA, responsable notamment de la sécrétion de cortisol. Or, la graisse viscérale – celle qui entoure les organes – est sensible aux signaux hormonaux. Plusieurs études observent une association entre stress prolongé et augmentation du tissu adipeux abdominal, notamment via des marqueurs de cortisol mesurés sur le long terme.Mais le cortisol ne “crée” pas des kilos par magie. Ce qui compte reste l'équilibre énergétique global. En revanche, le stress peut perturber l'appétit, altérer la sensibilité à l'insuline et surtout dégrader le sommeil.Le facteur comportemental est souvent déterminant : sous pression, on dort moins, on bouge moins, on grignote davantage, on consomme plus d'alcool ou d'aliments réconfortants. Sur la durée, ces changements peuvent augmenter le tour de taille.Attention aussi à ne pas confondre ballonnements liés aux tensions et véritable accumulation de graisse abdominale.Le message clé : le stress n'agit pas seul, mais il peut créer un terrain favorable. Priorité à trois piliers simples et puissants : sommeil de qualité, mouvement quotidien et repas structurés.

→ My one stop shop for quality supplements: https://theswellscore.com/pages/drg Episode Description If coffee isn't cutting it anymore—and you're exhausted but still can't sleep—this episode is for you. That "wired but tired" feeling isn't a sleep problem or even a stress problem. It's your HPA axis stuck in overdrive. Your body can't tell the difference between a work deadline and a life-threatening emergency, so your stress response never shuts off. The supplement industry knows you're burned out. That's why they're pushing adrenal cocktails, proprietary blends with pixie dust dosing, and adaptogens stacks with zero human research behind them. Dr. Christian Gonzalez cut through the noise to find the five most clinically validated adaptogens—herbs proven in randomized controlled trials to actually restore your stress response. In this episode, Dr. G breaks down: • The adaptogen that reduced cortisol by 27% in a meta-analysis of 25 human trials • Which Soviet-era herb improved VO2 max and is still used by athletes today • The "Queen of Herbs" that lowered inflammatory markers by 28% in stressed adults • Why one popular adaptogen might cause emotional flatness in certain people—and who should avoid it • The Arctic root that pulled people out of burnout in just four weeks He's ranking each adaptogen by strength of clinical evidence, walking through the mechanisms, exact dosing, who it's for, who it's not for, and the brands that actually test their products. Your adrenals aren't broken. They just need the right support. This episode gives you the clinical roadmap to get there. Timestamps: 0:00 - Introduction 2:15 - What's actually wrong (HPA axis explained)  4:30 - #5 Siberian Ginseng (Soviet secret weapon)  7:45 - #4 Holy Basil (the Queen of Herbs)  11:30 - #3 Korean Red Ginseng (results in 2 hours)  15:00 - #2 Rhodiola (the burnout fix)  19:30 - #1 Ashwagandha (king of adaptogens)  23:00 - Ashwagandha flatness warning (who should skip it)  26:30 - Exact dosing & best brands for each  28:45 - Dr. G's personal stack Learn more about your ad choices. Visit megaphone.fm/adchoices

In this final episode of the Progesterone Promise series, Dr. Brendan McCarthy, Chief Medical Officer of Protea Medical Center, breaks down one of the most misunderstood hormones in women's health: progesterone. Progesterone is not “good” or “bad.” It's contextual. In today's world of quick sound bites and social media medicine, hormones are often reduced to oversimplified claims like “progesterone fixes anxiety” or “progesterone causes breast cancer.” The truth? It depends on your body, your stress levels, your liver health, your inflammation, your delivery method, and whether you're using bioidentical progesterone or synthetic progestins.   Citations: 1. Oral Progesterone → First-Pass Metabolism & Allopregnanolone Claim: Oral micronized progesterone undergoes significant hepatic first-pass metabolism, increasing neuroactive metabolites (especially allopregnanolone), which positively modulate GABA-A receptors and produce sedative/anxiolytic effects. Core Evidence: Simon et al., 1993; de Lignières et al., 1995; Freeman et al., 1990 — Oral progesterone produces measurable neuroactive metabolites. Paul & Purdy, 1992; Rupprecht et al., 2001 — Allopregnanolone enhances GABA-A receptor activity. Supports: Sedation variability by route • Neurosteroid generation • GABA-A modulation 2. Sulfation vs 5α-Reduction → Opposing Neurologic Effects Claim: Progesterone metabolites can produce calming (5α-reduced) or excitatory (sulfated) neurologic effects depending on enzyme routing. Core Evidence: Majewska et al., 1990 — Pregnenolone sulfate negatively modulates GABA-A. Wu et al., 1991 — Sulfated neurosteroids enhance NMDA signaling. Schumacher et al., 2007; Reddy, 2010 — Pathway reviews of sulfation vs 5α-reduction. Supports: Reverse responding hypothesis • Divergent neurologic experiences • Enzyme-dependent effects 3. Stress & Enzyme Modulation Claim: Chronic stress alters HPA axis tone and hepatic enzyme expression, influencing steroid metabolism balance. Core Evidence: McEwen, 1998 — Allostatic load model. Charmandari et al., 2005 — Cortisol's systemic regulatory effects. Zanger & Schwab, 2013; Gibson & Skett, 2001 — Stress alters cytochrome P450 expression. Supports: Stress-biased metabolism • Context-dependent hormone response 4. Breast Tissue Signaling & Context Claim: Progesterone influences mammary differentiation and interacts with estrogen signaling in context-dependent ways. Core Evidence: Brisken & O'Malley, 2010 — Progesterone receptor biology in breast tissue. Beleut et al., 2010 — RANKL mediates progesterone-driven proliferation. Hofseth et al., 1999 — PR-ER signaling interaction. Stanczyk & Bhavnani, 2014 — Natural vs synthetic differences in breast effects. Supports: Lobuloalveolar differentiation • RANKL pathway • Context-dependent proliferation 5. Synthetic Progestins vs Bioidentical Progesterone Claim: Synthetic progestins differ structurally and bind off-target receptors, producing distinct tissue effects. Core Evidence: Stanczyk et al., 2013 — Receptor binding differences. Sitruk-Ware, 2004 — Biologic comparisons. Chlebowski et al., 2003 (WHI) — Breast cancer signal with CEE + MPA. Supports: Structural divergence • Receptor-level differences • WHI clarification 6. Route of Delivery Differences Claim: Oral, vaginal, transdermal, and sublingual progesterone produce distinct pharmacokinetic profiles and tissue targeting. Core Evidence: Simon, 1995 — Oral vs vaginal PK comparison. Cicinelli et al., 2000 — “First uterine pass effect.” Wren et al., 2003 — Route-dependent systemic levels. Supports: Uterine targeting • Neurosteroid variability • Sedation differences 7. Progesterone, PMS & Migraine Claim: Neurosteroid fluctuations influence GABAergic tone and may contribute to PMS and migraine susceptibility. Core Evidence: Backstrom et al., 2011 — Allopregnanolone fluctuations in PMS. Reddy & Rogawski, 2002 — Neurosteroids and seizure threshold. Martin & Behbehani, 2001 — Hormonal fluctuations and migraine. Supports: Luteal neurosteroid shifts • GABA instability • Migraine association   Dr. Brendan McCarthy is the founder and Chief Medical Officer of Protea Medical Center in Arizona. With over two decades of experience, he's helped thousands of patients navigate hormonal imbalances using bioidentical HRT, nutrition, and root-cause medicine. He's also taught and mentored other physicians on integrative approaches to hormone therapy, weight loss, fertility, and more. If you're ready to take your health seriously, this podcast is a great place to start.  

In this solo episode, Dr. Mindy Pelz breaks down nervous system dysregulation and HPA axis dysfunction what it is, why so many women are stuck in chronic stress, and how it shows up as fatigue, anxiety, insomnia, belly fat, and mood swings. Drawing from a 2025 review in the American Journal of Medicine, she explains the six most common causes of HPA axis dysfunction and shares seven practical, science-backed ways to regulate your nervous system naturally. If you've felt wired, overwhelmed, or exhausted lately, this episode will help you understand why and what you can do about it. To view full show notes and resources, visit:

Tune in for our conversation with Dr. Stephen Cabral where he breaks down why even health-conscious biohackers can struggle with chronic symptoms, pointing to hidden imbalances that standard approaches often miss. He emphasizes starting with gut and immune health and explains why comprehensive lab testing, especially Hair Tissue Mineral Analysis (HTMA), offers insights that blood work alone can't capture. The conversation explores how stress, electrolyte imbalances, and heavy metal exposure quietly drain resilience, making proper detoxification and mineral balance essential. Dr. Cabral also shares practical guidance on magnesium, zinc, copper, iron, and adrenal support, tailoring advice for high performers under constant pressure. We also dive into our personal HTMA results so you can get a front row seat on what a typical HTMA consultation looks like. Throughout the episode, he underscores that optimal health isn't just about supplements and protocols, but also mindset—building “stress calluses” and taking a truly holistic, systems-based approach.Dr. Stephen Cabral is a Board-Certified Doctor of Naturopathy and founder of EquiLife, the global integrative health organization providing at-home lab testing, personalized wellness protocols, and concierge health coaching to over 300,000 clients over the past 25 years.He also founded the Integrative Health Practitioner Institute (IHPI), which has certified over 5,000 practitioners globally, and hosts The Cabral Concept podcast with 3,500+ episodes and 100 million+ downloads.After overcoming a life-threatening illness at 17, Dr. Cabral went on to get his doctoral degree and completed over 2,200 internship hours all over the world including India, Sri Lanka, China, Europe, and the U.S.SHOW NOTES:0:42 Welcome to the podcast!3:13 About Dr. Stephen Cabral4:12 Welcome him to the show!4:48 Why do healthy people get sick?7:48 Addressing gut & immune system first10:36 Starting with HTMA Testing12:21 Electrolytes in hair vs blood work15:12 Validity of HTMA16:05 Overview of our results interpretation18:09 Lauren's HTMA results22:38 Supporting the HPA axis with electrolytes24:33 Magnesium recommendations25:29 Iron, Copper & Zinc31:51 Advice for high performers & high achievers33:44 *CALOCURB*34:56 Lauren's heavy metals41:17 Renee's HTMA results44:32 Creating stress “calluses”50:21 Renee's heavy metals52:50 Finding a Biological Dentist54:47 Where else metals are stored56:42 Adrenal support ingredients57:25 Zinc & Copper balancing1:03:45 Minerals & Metals Test1:05:32 His final piece of advice1:06:50 Thanks for tuning in!RESOURCES:Calocurb - discount code: RENEE10Website: www.drstephencabral.comIG: @stephencabralYouTube50% off the Minerals & Metals TestBook: PersonomicsCoaching: sign up for the Personomics waitlist at:Personomics.ioThe Julian Center for Comprehensive DentistryTo find a Biological Dentist: iaomt.orgSupport this podcast at — https://redcircle.com/biohacker-babes-podcast/donationsAdvertising Inquiries: https://redcircle.com/brands

You've done it a hundred times. You're sitting at your desk, everything's fine, and then your hand is reaching for the snacks before you even realize something's wrong. The stress doesn't hit for another ten minutes. But your body is already eating.And later that night, you blame yourself. You call it weakness. You promise tomorrow will be different.In this episode, Rick breaks down the three specific brain hijacks that fire before your conscious mind gets a vote, why willpower never stood a chance against them, and how to rewire each one. This is the science the diet industry will never tell you, because it would put them out of business.Key points discussed:Your amygdala processes stress through a "low road" that bypasses conscious awareness entirely, triggering cravings and food-seeking behavior before your thinking brain even knows something is wrong.Cortisol accumulates over hours, sometimes based on nothing more than your brain's prediction that today will be stressful. By the time you feel it, the cravings are already locked in.Roughly 43% of daily behavior is habitual. Your stress-eating loops were built from years of pairing food with emotional relief, and they execute without your permission.Willpower lives in the prefrontal cortex. These three hijacks operate underneath it, faster than it, and earlier than it. You were never losing a discipline battle. You were being ambushed by biology.Mentioned in this episodeThe Circuit Breaker Protocol (free download): https://www.weightlossmindset.co/7hijacksThe "low road" and "high road" of threat processing (LeDoux, neuroscience of amygdala pathways)USC research on habitual behavior (Dr. Wendy Wood, 43% of daily actions are automatic)Research on cortisol, chronic stress, and food cravings (HPA axis activation and appetite-related hormones)ConnectSubscribe to The Weight Loss Mindset on Substack for weekly deep dives, daily audio content, and the full course library: https://news.weightlossmindset.coGot a question or a moment from this episode that hit home? Reply to any Substack email or leave a comment. I read every one.You weren't broken. You were hijacked. And now you know how.

You've heard of burnout. But what if the real crisis starts long before the breaking point? In this short opener, host Stacie introduces allostatic load — the scientific term for the cumulative "wear and tear" the body accumulates under chronic, unresolved stress. It's not a bad week. It's what happens when the body never fully recovers, and the nervous system learns to treat survival mode as its new normal. Research shows women carry a disproportionate allostatic burden — driven not just by biology, but by the invisible labor, emotional weight, and systemic pressures that don't clock out at 5pm. And for leaders and HR professionals, this matters: what often looks like a performance problem in your workforce may actually be a health signal hiding in plain sight. This episode opens a series that follows allostatic load where it leads — into autoimmune disease, hormonal disruption, ADHD, and what it truly costs women, leaders, and organizations when we keep misreading the signal. Under 5 minutes. But it might change how you see everything else. Stacie Origins of the Term The concept of allostasis — meaning "stability through change" — was first introduced by neurobiologist Peter Sterling and epidemiologist Joseph Eyer in 1988 to describe how the brain dynamically recalibrates internal physiological systems in anticipation of environmental demands, rather than simply reacting to them. Building on this foundation, neuroscientist Bruce McEwen and physiologist Eliot Stellar coined the term allostatic load in 1993, defining it as the cumulative physiological "wear and tear" the body experiences when allostatic systems are chronically activated, fail to shut off, or never perform normally. McEwen later described this as "the price of adaptation" — the physiological cost the body pays for sustained attempts to manage chronic stress. The Biological Cascade: What Happens in the Body When the brain perceives a stressor — real or anticipated — it activates two primary physiological systems: the sympathetic-adrenal-medullary (SAM) axis, which releases catecholamines (adrenaline, noradrenaline), and the hypothalamic-pituitary-adrenal (HPA) axis, which releases glucocorticoids, primarily cortisol. In the short term, these responses are adaptive and protective. However, under conditions of chronic, unresolved stress, this cascade remains activated. Over time, the brain and organ systems undergo measurable physiological changes: ↑  Elevated cortisol, epinephrine, and norepinephrine (neuroendocrine markers) ↑  Elevated inflammatory markers: C-reactive protein (CRP), interleukin-6 (IL-6), fibrinogen ↑  Dysregulated blood pressure, lipid levels, glycated hemoglobin (metabolic markers) ↓  DHEA (dehydroepiandrosterone) — the protective counterpart to cortisol A 2001 landmark study using the MacArthur Studies of Successful Aging demonstrated that higher allostatic load scores at baseline were significantly associated with increased 7-year mortality risk and declines in both cognitive and physical functioning. A comprehensive 2020 systematic review of 267 studies confirmed that allostatic load and allostatic overload are robustly associated with poorer physical and mental health outcomes across a wide range of conditions.

In this episode of Call Your Hits, Phil, Pat and Mat engage in a lively discussion about airsoft gear, focusing on the practicality and cost-effectiveness of various items. They explore the importance of feedback in making purchasing decisions, debate the merits of specific equipment like the M240 Bravo and HPA systems, and share personal experiences with grenades and accessories. The conversation emphasizes the balance between enjoyment and practicality in the airsoft community, encouraging listeners to think critically about their gear choices. In this engaging conversation, the hosts delve into the world of airsoft, discussing various gear options, strategies, and the balance between practicality and passion. They explore the appeal of grenade launchers and gas blowback guns, while also addressing the financial considerations of purchasing new equipment. --- If you're looking to support the channel, check out our merch store here: https://stormriders.threadless.com/ And join our discord by following this link: https://discord.gg/ZdaftDDYaZ

Corey Schuler is a holistic family nurse practitioner who discusses the circadian rhythm, the body's internal time clock, with host Dr. Ben Weitz. Both the central clock and peripheral time clocks control the metabolism of the body, our sleep, alertness, body temperature, and even our gene expression.  Our modern lifestyle, lack of sleep, exposure to artificial and blue light, caffeine consumption, etc. has had a negative impact on our natural circadian rhythm and this may result in many negative health consequences.  We discussed how stress, adrenal function, and the HPA axis impact our circadian rhythm. [If you enjoy this podcast, please give us a rating and review on Apple Podcasts, so more people will find The Rational Wellness Podcast. Also check out the video version on my WeitzChiro YouTube page.]  Corey Schuler is a holistic family nurse practitioner who practices at Synergy Family Physicians in Minnesota and the website is SynergyFamilyPhysicians.com. Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure.  Dr. Weitz has also successfully helped many patients with managing their weight and improving their athletic performance, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111.

You're exhausted but wired at bedtime. Or you fall asleep fine, but jolt awake at 3 AM with your mind racing. If you're waking up at the same time every night and can't figure out why, this episode is for you. I'm breaking down the midnight triangle—the intricate relationship between sleep, cortisol, and blood sugar that's keeping you awake. Spoiler alert: it has nothing to do with your mattress or pillow. This is your body sending you a loud SOS signal.In this episode we explore:Why blood sugar crashes trigger 3 AM wake-ups (and how cortisol and adrenaline are involved)How your HPA axis gets dysregulated under chronic stress, keeping you "tired but wired"The vicious cycle between poor sleep, high cortisol, and insulin resistanceWhy perimenopause makes sleep worse (hello, declining progesterone)Five practical solutions you can implement tonight to start sleeping betterResources:Free Webinar: Why Am I Waking at 3 AM Every Night? February 12th at 11 AM Mountain TimeTake my “What Hormone is Running the Show” QuizJoin my Hormone Unfiltered NewsletterAbout KateKate Nguy is the founder of Shee Revival and a Certified Hormone Health Practitioner and Cycle-Syncing Strategist who helps busy women in their 30s and 40s balance their hormones and reclaim their energy. Specializing in the hormonal ups and downs of midlife—from PMS and perimenopause to burnout and cortisol overload—Kate guides women to feel at home in their bodies and live in sync with their natural cycles. Through cycle syncing, hormone hacks, and nervous system regulation, Kate empowers women to rebalance their hormones, reconnect to their bodies, and revive the vibrant, grounded version of themselves underneath the overwhelm.Tune in now and join the movement toward better hormone health!Follow me @hormoneswithkate on Instagram for more insights, tips, and support!

In this episode of Trauma Rewired, we explore autoimmune conditions through a nervous-system and psychoneuroimmunology lens—moving beyond the idea that the body is "attacking itself." Instead, we examine autoimmunity as an adaptive output of a system that has lived in chronic threat for too long. Jennifer Wallace and Elisabeth Kristof unpack how immune response, emotional expression, boundaries, trauma history, and social stress intersect at the level of physiology. Drawing on research from ACEs, chronic inflammation, the HPA axis, the inflammatory reflex, and shame-based immune activation, they explain how the brain's predictions—rather than isolated biology—shape immune behavior. You'll hear why autoimmune conditions disproportionately affect women and marginalized communities, how emotional suppression and boundary violations translate into inflammation, and why anger, shame, and safety are biological—not just psychological—processes. The episode closes with a grounded conversation on post-traumatic growth: what it means to live in partnership with the body, retrain predictions through sensory and interoceptive work, and expand resilience alongside medical care. This is an invitation to replace self-blame with curiosity—and to see regulation, expression, and safety as central to immune health.     Timestamps 00:00 – Intro: Autoimmune as protection, not self-attack 08:40 – Autoimmune, ACEs, gender, and nervous system prediction 21:05 – Chronic inflammation, HPA axis & the inflammatory reflex 35:20 – Boundaries, anger, shame & post-traumatic growth 52:00 – Closing reflections & integration     Key Takeaways Autoimmune responses can be understood as nervous-system outputs shaped by prediction and chronic threat. Early adversity, emotional suppression, and social stress significantly increase inflammatory load. Boundaries are physiological capacities rooted in interoception and proprioception—not just communication skills. Training safety, expression, and regulation can complement medical care and reduce flare frequency.     Call to Action:   Join us for a free NSI workshop Feb 11: Integrating the Nervous System with Precision and Purpose: https://neurosomaticintelligence.com/integration-workshop/   Learn to work with Boundaries at the level of the body and nervous system at boundaryrewire.com Sacred Synapse: an educational YouTube channel founded by Jennifer Wallace that explores nervous system regulation, applied neuroscience, consciousness, and psychedelic preparation and integration through Neurosomatic Intelligence.  Wayfinder Journal: Track nervous system patterns and support preparation and integration through Neurosomatic Intelligence. FREE 1 Year Supply of Vitamin D + 5 Travel Packs from Athletic Greens when you use my exclusive offer: https://www.drinkag1.com/rewired    Get a two-week free trial of neurosomatic training at rewiretrial.com Resources Mentioned NIH – Autoimmune Diseases & Women: https://orwh.od.nih.gov/research/maternal-morbidity-mortality/autoimmune-diseases Danese & Lewis (2017) Psychoneuroimmunology of Early-Life Stress: https://pubmed.ncbi.nlm.nih.gov/27860545/ Dube et al. (2009) ACEs & Autoimmune Risk: https://pubmed.ncbi.nlm.nih.gov/19234146/ McEwen & Gianaros (2016) Stress, Brain & Disease: https://pubmed.ncbi.nlm.nih.gov/26766224/ Dickerson & Kemeny (2004) Shame, Social Threat & Inflammation: https://pubmed.ncbi.nlm.nih.gov/15250837/   Disclaimer: Trauma Rewired podcast is intended to educate and inform but does not constitute medical, psychological or other professional advice or services. Always consult a qualified medical professional about your specific circumstances before making any decisions based on what you hear. We share our experiences, explore trauma, physical reactions, mental health and disease. If you become distressed by our content, please stop listening and seek professional support when needed. Do not continue to listen if the conversations are having a negative impact on your health and well-being. If you or someone you know is struggling with their mental health, or in mental health crisis and you are in the United States you can 988 Suicide and Crisis Lifeline. If someone's life is in danger, immediately call 911. We do our best to stay current in research, but older episodes are always available. We don't warrant or guarantee that this podcast contains complete, accurate or up-to-date information. It's very important to talk to a medical professional about your individual needs, as we aren't responsible for any actions you take based on the information you hear in this podcast. We invite guests onto the podcast. Please note that we don't verify the accuracy of their statements. Our organization does not endorse third-party content and the views of our guests do not necessarily represent the views of our organization. We talk about general neuro-science and nervous system health, but you are unique. These are conversations for a wide audience. They are general recommendations and you are always advised to seek personal care for your unique outputs, trauma and needs. We are not doctors or licensed medical professionals. We are certified neuro-somatic practitioners and nervous system health/embodiment coaches. We are not your doctor or medical professional and do not know you and your unique nervous system. This podcast is not a replacement for working with a professional. The BrainBased.com site and RewireTrial.com is a membership site for general nervous system health, somatic processing and stress processing. It is not a substitute for medical care or the appropriate solution for anyone in mental health crisis. Any examples mentioned in this podcast are for illustration purposes only. If they are based on real events, names have been changed to protect the identities of those involved. We've done our best to ensure our podcast respects the intellectual property rights of others, however if you have an issue with our content, please let us know by emailing us at traumarewired@gmail.com. All rights in our content are reserved.  

We talk a lot about slowing down and how it's really good for us, but we talk much less about what it means to stay.  Like really stay.... without doing it for productivity gains.  This episode explores holding space for yourself,  not as a technique, but as a way of inhabiting yourself, experiencing yourself without the need to learn from it yet (and why that's really good for your HPA axis!)Join me for this short but profound episode. ******************‘Becoming' is the new membership I've created for this phaseBecoming is a space for women in this in-between phase where old identities no longer fit, and new ones haven't fully arrived yet.The waitlist is now open.

How do you keep training when life gets stressful? Whether you're navigating a new job, new baby, a big move, or personal loss, your body processes all stress the same way—and that changes everything about how you should train.In this episode, we break down the science of stress and running performance, including how the HPA axis works, why your "stress bucket" has a finite capacity, and why the same workout that built fitness last year might dig a hole this year. We share six practical principles for training through life transitions without burning out or losing the fitness you've built.We also tackle Hot or Nots on splitting your runs (why two 4-milers isn't the same as one 8-miler) and running in extreme cold (when to embrace the treadmill). Plus, we debunk that viral Noakes study claiming you only need 10 grams of carbs per hour—spoiler: it's a cherry-picked narrative review from low-carb advocates with ketone patents.What you'll learn:– How cortisol and the HPA axis affect your training and recovery– The "stress bucket" model and why your capacity changes during transitions– Why RPE increases at the same pace when life stress is high– How to flip your training hierarchy so life leads and running follows– The detraining timeline (it's slower than you think)– How to set "conditions of enoughness" for your current season– Why frequency beats volume during chaotic periodsAlso in this episode: Meet Coach James Nance, who specializes in multi-sport athletes, injury cycles, and RED-S recovery.microcosmcoaching@gmail.com | microcosm-coaching.com | Join our Foothills community for $10/month

Explore how adaptogens regulate the HPA axis, metabolism, and neurotransmitters to enhance stress resilience and cellular repair. #Adaptogens #HPAaxis #MetabolicHealth #HealthTalks

Join Our Online Education Community "The School of Doza" Here: https://community.schoolofdoza.com/ In this podcast episode, Nurse Doza discusses the common complaint of fatigue and offers insights into its possible causes. He emphasizes the importance of addressing fatigue, as it should not be a daily occurrence. He also recommends getting blood tests, particularly one for DHEAS, to assess adrenal function and the body's response to stress. He mentions that chronic stress, lack of sleep, and unhealthy lifestyle habits can contribute to fatigue. Nurse Doza encourages listeners to prioritize self-care, including good sleep and stress management, to improve their energy levels and overall health.   TIMESTAMPS: 00:00 START 05:50 Adrenal issues can cause fatigue. 11:46 Inflammation and fatigue are connected. 16:34 Address underlying causes of fatigue. 22:08 Check homocysteine levels for fatigue. 27:43 Sugar and inflammation decrease ATP. 32:15 Adrenal support supplement is recommended.     Looking for a boost in energy and mood? Discover Zen, MSW's premium adrenal support supplement. Packed with natural ingredients, it aids in balancing your hormones and combating fatigue. Elevate your health and regain that lost zest for life.  Click here

The wired-but-tired feeling is incredibly common, especially for women, and it's one of the most frustrating places to be. You want energy during the day. You want sleep at night. But instead, it feels like your body is doing the exact opposite of what it should. In this episode, I'm breaking down what's actually happening behind the scenes when you feel wired but tired and why pushing harder, drinking more coffee, or just "trying to relax" usually makes things worse. When I see this pattern, it almost always points back to dysfunction in the HPA axis, which controls your adrenal function and cortisol output. A lot of women call this adrenal fatigue or adrenal insufficiency. Here's the key thing most people miss: You can feel exhausted and overstimulated at the same time. This often happens when: Your adrenal output is low, so you don't have sustained energy Your free cortisol is elevated, because life is stressful and you're constantly in reaction mode You're running on adrenaline instead of real energy That's why you may feel okay only when there's a fire to put out, then crash hard afterward. Cortisol can be measured through saliva or urine, but a single snapshot doesn't tell the whole story. This is where DUTCH testing is so powerful: It shows free cortisol across the entire day, not just one moment It shows metabolized cortisol, which saliva testing cannot measure It reveals whether your body is producing cortisol, using it properly, or struggling to keep up What I see over and over again with wired-but-tired women is low adrenal function paired with high free cortisol. You're stressed, busy, and carrying a lot, but your system no longer has the reserves to support it. This pattern doesn't just affect energy. It can disrupt: Sleep cycles and nighttime rest Hormone regulation Muscle recovery and rebuilding Immune function Mood, focus, and motivation This is why advice like "just eat healthier," "go to yoga," or "push through it" doesn't work. Those approaches don't address the root issue. The first step is understanding what your body is actually doing. That's why I rely so heavily on DUTCH testing. It gives us a clear roadmap instead of guessing. From there, we can build the right plan for you, whether that means: Supporting protein and mineral intake Repairing sleep and circadian rhythms Addressing stress physiology in a way your body can actually respond to Rebuilding adrenal resilience instead of draining it further If you're stuck in that Groundhog Day cycle of exhaustion and overstimulation, this is your sign to stop guessing and start testing. Click the link below to learn more about the DUTCH test: https://drbethwestie.com/dutch-hormone-testing/

"Poor egg quality" is not a diagnosis. It's where clinics stop looking. If you've been told you have poor egg quality after failed IVF, low AMH, embryo arrest, or recurrent pregnancy loss, this episode will change how you understand that label and what to do next. Here's the truth most women are never told: poor egg quality is not directly measured. It's a conclusion clinics infer based on age, embryo grading, or how your ovaries responded to stimulation. When IVF fails, that label often becomes the end of the conversation instead of the beginning of a deeper investigation. In this episode, I break down the five physiological patterns we see repeatedly in women with low AMH, failed IVF, embryo arrest, and pregnancy loss and why correcting these patterns can lead to pregnancy even when AMH does not change. In this episode, you'll learn: Why "poor egg quality" is a label, not a test result and what clinics are actually inferring How gut and vaginal microbiome stress drive inflammation and impair nutrient absorption critical for egg development Why mineral depletion disrupts mitochondrial energy, hormone signaling, and cellular communication in the ovary How blood sugar instability and circadian disruption interfere with ovulation and progesterone Why nervous system overload and HPA-axis patterns affect immune balance, implantation, and early embryo development I'm Sarah Clark, founder of Fab Fertile and host of Get Pregnant Naturally. For over a decade, my team and I have reviewed hundreds of failed IVF cases and helped couples improve pregnancy outcomes naturally and alongside IVF. We specialize in low AMH, high FSH, diminished ovarian reserve, premature ovarian insufficiency, and recurrent pregnancy loss using functional testing and personalized fertility strategies. This episode is for you if: You were told you have poor egg quality with no clear explanation why IVF failed, embryos stopped growing, or all embryos tested were abnormal You don't want another medication tweak or repeated protocol, you want answers

Good afternoon, I'm _____ with today's episode of EZ News. Tai-Ex opening The Tai-Ex opened up 183-points this morning from Friday's close, at 30,472 on turnover of 10.8-billion N-T. The market closed lower on Friday, but remained above the 30,000 point mark on the back of investor optimism that Taiwan Semiconductor Manufacturing would report strong sales for 2025 after the main board closed. Lai announces approval of NT$2.94 billion 'smart health' subsidies President Lai Ching-te says his administration has approved 197 subsidy programs worth about 2.94-billion N-T under a plan to encourage medical institutions to adopt 'smart health care' technologies. The subsidy programs are part of the five-year 48.9-billion N-T Healthy Taiwan Cultivation Plan, which the government launched last year. Speaking at the opening ceremony of the 2026 Nobel Health Care Forum in Taipei, Lai said the subsidy programs are designed to leverage (利用，發揮（優勢）) the advantages of smart health care to strengthen medical services. According to Lai, although average life expectancy in Taiwan is currently above 80, people spend an average of 8.4 years in poor healthand that means "about 10-per cent of the average lifespan is unhealthy," with some people bedridden, using wheelchairs or needing daily care. HPA to publish new dietary guidelines in Q2 2026 Health Minister Shih Chung-liang says the Health Promotion Administration will issue new daily dietary guidelines in the second quarter of this year. It will be the first such update since 2018. A draft of the new guidelines was completed late last year. According to Shih, eggs will be promoted more than in the past, given the growing body of research (大量的研究成果) showing they are an excellent source of nutrition. And while earlier guidelines only recommended skim or low-fat milk, the updated guidelines recognize that whole milk contains important nutrients, as long as it is consumed in moderation as part of a balanced diet. US Minnesota More Immigration Arrests Minnesota braces for what's next amid (…之中) more protests and immirgration arrests AP's Lisa Dwyer reports Italy Olympic Venue Guard Death Authorities have confirmed the death of a guard at construction site near a 2026 Winter Olympic venue in the mountain resort of Cortina d'Ampezzo. The death occurred during a frigid overnight shift, when temperatures plunged to minus 12 degrees Celsius. Italy's infrastructure minister has called for a full investigation into the circumstances surrounding the 55-year-old worker's death. Italian media reported that the death happened on Jan. 8, outside Cortina's ice arena, and Milan Cortina organizers said that the worker died of a heart attack. City officials expressed deep sadness and concern (憂慮) over the incident. The Milan Cortina Winter Olympics are scheduled for Feb. 6-22. That was the I.C.R.T. EZ News, I'm _____. -- Hosting provided by SoundOn

On this episode of Vitality Radio, Jared launches a new series called Extraordinary Herbs, starting with one of the most widely used—and misunderstood—herbs today: ashwagandha. You'll learn how to use ashwagandha effectively in the real world, why extract type matters, how the most popular forms differ, and what actually determines results for different people. Jared breaks down what modern human research shows, as well as how this herb was traditionally used. Often labeled as the “de-stress herb,” ashwagandha shines as so much more! It supports healthy cortisol signaling, influencing sleep quality, hormone balance, exercise recovery, cognitive function, immune resilience, and thyroid health through the HPA axis. This episode breaks it all down without hype or confusion. Products:Sensoril AshwagandhaVital SleepAnxiety ReleaseMan Up!Man Up! Vital Test10 Days of SunshineNightburnVisit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful and @vitalityradio on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.

You're about to learn how government approved food policies, regulatory loopholes, and corporate lobbying have quietly reshaped what's allowed in the food supply and why these decisions are driving chronic inflammation, immune dysfunction, and neurological breakdown at scale. This episode exposes how biotoxins, ultra processed ingredients, and systemic regulatory failures contribute to long COVID, POTS, mold illness, chronic fatigue, and dysautonomia and why so many people feel sick despite following official health guidance. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Will Cole, a functional medicine expert who works extensively with autoimmune disease, mold illness, hormonal dysfunction, digestive disorders, and complex brain related symptoms. Dr. Cole brings years of clinical experience analyzing lab data and treating patients with biotoxin exposure, neuro immune dysregulation, and chronic fatigue patterns. Together, they connect the dots between mold exposure, post viral illness, mast cell activation, low blood pressure, and why many people with long COVID or POTS feel dizzy, inflamed, and cognitively impaired. They explain how histamine overload, electrolyte depletion, cortisol imbalance, and genetics combine to disrupt blood flow to the brain and shut down human performance. The conversation focuses on practical functional medicine and biohacking tools that help rebuild resilience at the mitochondrial and nervous system level. You'll Learn: • Why long COVID, mold illness, POTS, and chronic fatigue often share the same biological drivers • How biotoxins like mold and viral exposure dysregulate the neuro immune endocrine axis • Why low blood pressure reduces blood flow to the brain and causes brain fog and fatigue • What mast cell activation syndrome is and how histamine overload affects the body and brain • Why electrolytes, especially sodium, potassium, and magnesium, are foundational for recovery • How creatine supports brain energy, hydration, and mitochondrial function • The role of cortisol in inflammation, stress tolerance, and nervous system stability • When antihistamines and mast cell stabilizers can improve quality of life • How nicotine acts as a low dose neuroprotective compound when used carefully • The benefits and risks of methylene blue for mitochondrial and cognitive support • Why removing the trigger matters more than chasing symptoms • How a functional medicine approach rebuilds resilience instead of masking dysfunction • Why creatine absorption improves when added to hot coffee • How Danger Coffee fits into performance, hydration, and brain energy Thank you to our sponsors! - IGNITON | Go to http://igniton.com/ and use code DAVE for 15% off your first order. -TRU KAVA | Go to https://trukava.com/ and use code DAVE10 for 10% off. -Caldera + Lab | Go to https://calderalab.com/DAVE and use code DAVE at checkout for 20% off your first order. -LYMA | Go to https://lyma.sjv.io/gOQ545 and use code DAVE10 for 10% off the LYMA Laser. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: long COVID, POTS syndrome, dysautonomia, mold illness, biotoxin illness, mast cell activation, histamine intolerance, low blood pressure brain fog, chronic fatigue syndrome, mitochondrial dysfunction, cortisol imbalance, electrolytes sodium potassium, creatine brain energy, functional medicine long COVID, nicotine neuroprotection, methylene blue mitochondria, brain fog causes, neuro immune dysfunction, will cole dave asprey, will cole biohacking Resources: • Dr. Will Cole's Website: https://drwillcole.com/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 - Trailer 1:25 - Introduction 2:20 - Conspiracy and misinformation 9:07 - Vaccine safety and fertility 12:48 - Big Food front groups 19:38 - POTS, dysautonomia, biotoxins 20:51 - HLA genetics and immunity 25:11 - Mast cells and histamine 28:41 - Electrolytes and sodium 33:37 - Cortisol and inflammation 35:01 - HPA axis burnout 39:22 - Bioidentical cortisol support 40:27 - Methylene blue and mitochondria 46:51 - Methylation and MTHFR 49:57 - Folinic acid and homocysteine 52:52 - Creatine in coffee hack See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Fight-or-flight is driving many perimenopause and menopause symptoms, even when your labs look "normal." In part two of this four-part series, Maraya Brown explains how stress, the HPA axis, and nervous system regulation impact hormones and shares simple tools to restore balance, calm, and vitality.   Book a 1:1 call with Maraya and start restoring your energy: https://marayabrown.com/call/  Get the WVA Trifecta and support your body's natural healing: https://marayabrown.com/trifecta  Link to the workbook: https://drive.google.com/file/d/1MxiR8nQKwVSksSNRiEzNfsTLfU2IEHWu/view?usp=sharing   Join our Retreat: https://marayabrown.com/ashland-retreat/     The Women's Vibrancy Accelerator Trifecta: Your 90-Day Health Reset Ready to take your health to the next level? The Women's Vibrancy Accelerator Trifecta offers deep, personalized support to help you regain control of your energy, hormones, and well-being. This program includes: Three one-on-one calls with Maraya Dutch Plus Test and full assessment Bi-weekly live Q&A sessions Self-paced health portal covering energy, hormones, libido, and confidence   Podcast listeners get an exclusive discount. Use code PODCAST. Learn more and enroll now: https://marayabrown.com/trifecta/ _______________________ Free Wellness Resources Access free tools like the Menstrual Tracker, Adaptogen Elixir Recipes, Two-Week Soul Cleanse, Food Facial, and more. Download now: https://marayabrown.com/resources/ _______________________ Subscribe to The Women's Vibrancy Code Podcast Listen on Apple Podcasts, YouTube, and Spotify. _______________________ Connect with the Show Find us on Facebook,  Linkedin | Website | Tiktok | Facebook Group _______________________ Apply for a Call with Maraya Brown Start your journey with personalized support. Apply here: https://marayabrown.com/call  _______________________ About Maraya Brown Maraya is a Yale and Functional Medicine-trained Women's Health and Wellness Expert (CNM, MSN). She helps women feel energized, confident, and connected to themselves and their lives. With over 25 years of experience, she specializes in energy, hormones, libido, confidence, and deep transformation. _______________________ Disclaimer The content of this podcast is for informational, educational, and entertainment purposes only and does not constitute medical or professional advice. Listeners should consult with a qualified professional before making any health decisions.     This Podcast Is Produced, Engineered & Edited By: Simplified Impact 

What if the anxiety, burnout, inflammation, or exhaustion you carry didn't begin with you?In this solo episode, Dr. Taz explores the emerging science behind generational trauma and how stress, fear, and survival patterns can be passed down biologically through mitochondrial DNA, the nervous system, and hormonal pathways. She explains why some people struggle with symptoms that don't resolve despite doing everything right, and how ancestral trauma may be quietly shaping inflammation, cortisol levels, emotional regulation, and energy production across generations.You will learn how trauma can alter mitochondrial function, disrupt the HPA axis, and create inherited patterns of hypervigilance, anxiety, burnout, and chronic disease. Dr. Taz introduces her five body map framework, physical, mental, emotional, spiritual, and community, to help you understand where inherited trauma may be showing up and how healing becomes possible when all layers are addressed.Dr. Taz shares: • How trauma can be transmitted biologically through mitochondrial DNA passed down the maternal line • Why chronic inflammation, insulin resistance, and cortisol dysregulation often appear in families with histories of displacement, silence, or survival stress • The signs of inherited nervous system patterns, including hypervigilance, fear based thinking, emotional suppression, and burnout that starts early • How ancestral trauma affects hormones, energy production, mental health, and emotional regulation • Why family secrets, shame, and silence can destabilize the entire family ecosystem and show up as disease • The five body map approach to screening generational trauma across physical, mental, emotional, spiritual, and community layers • Practical ways to begin healing, including nervous system regulation, storytelling, somatic release, mitochondrial support, and restoring safe connection within familiesWhether you are dealing with unexplained symptoms, chronic stress, emotional patterns that seem bigger than your life experience, or simply want to understand your family's health history more deeply, this episode offers a new lens on healing. You may inherit biology, but you can change how it is expressed and what gets passed forward.Stay Connected:Connect further to Hol+ at https://holplus.co/- Don't forget to like, subscribe, and hit the notification bell to stay updated on future episodes of hol+.Follow Dr. Taz on Instagram: https://www.instagram.com/drtazmd/https://www.instagram.com/liveholplus/Subscribe to the audio podcast: https://holplus.transistor.fm/subscribeSubscribe to the video podcast: https://www.youtube.com/@DrTazMD/podcastsGet your copy of The Hormone Shift: Balance Your Body and Thrive Through Midlife and MenopauseHost & Production TeamHost: Dr. Taz; Produced by ClipGrowth.com (Producer: Pat Gostek) (00:00) - Hi everyone, it's Dr. Taz. Before we get into today's episode, I just wanna pause and say thank you. Your messages, your shares, your stories are, the reason we make Whole Plus every conversation here is about connecting the science, the intuition, and everyday life together so you can feel more like yourself. (00:00) - if you haven't already hit that subscribe or follow button, it helps us reach more people who need this. All right, let's begin. What if the pain you [00:00:30] carry didn't start with you? Science now shows that trauma can be passed through generations, not just through stories or behaviors, but through biological changes in the body itself. (00:00) - this episode, we're exploring the connection between ancestral trauma and mitochondrial DNA and how your body might still be echoing the stress, the fear, or the survival patterns of your lineage. The gift of being in practice for over 16 years and seeing, I don't know how [00:01:00] many patients, I think collectively as, uh, a series of whole plus clinics were at 60, 70,000. (00:00) - the gift of seeing a patient day in and day out and following them through their journey. Allows us as providers a lot of time to think, observe, learn, and listen. And one of the things that has always confused me until recently is why some people have symptoms or have issues without any explanation.[00:01:30] (00:00) - done all the right things. They're following the diet, they're exercising, they are doing all the things they're supposed to do. They've got those wellness routines down, red, light, blue, light, you name it, they're doing it, but they're still not well. And while I could have a conversation with all of you about chemistry and biology and physiology, here's what maturity and time has taught me. (00:00) - healing and being well doesn't exist on [00:02:00] one plane. It's not just about the numbers and the data. It's actually a whole lot more, so much more that it may even be linked to your generational trauma. Now, bear with me for a second. Please don't roll your eyes and change the channel or flip the screen. (00:00) - is important information and we are just beginning to understand what all of this means and how it's all connected. I've had many opportunities to observe [00:02:30] this. Some of them begin right in our home. I have watched as the women in our family have a very similar look in their eye demeanor way of talking tone. (00:00) - name it. Some of it we could explain away. My mom was an immigrant, came here at a very young age, 17, 18, 19 years old, had an arranged marriage. She had, I thought, the insecurity of being an immigrant, of being somebody in a new [00:03:00] country without a community. And I always explained away her inability or fear. (00:00) - of in terms of taking action or taking next steps as a part of that story, the immigrant story, right? I, I can't imagine what so many immigrants go through to get here and then to build a life in a family of their own, leaving behind mothers and fathers, brothers and sisters, huge families. So I explained her story away that way. (00:00) - then there [00:03:30] was me and I grew up, as I've shared sometimes in a slightly chaotic, dysfunctional childhood home, and I don't wanna get into all of those details, but I had that same glimmer of fear and insecurity that I saw in my mom. But let's fast forward to my daughter all these years later, growing up in a pampered home with a father that dotes on her. (00:00) - we doted on her even a bit too much, but regardless, had all the comforts and the [00:04:00] security that anybody externally could provide. But guess what? The same glimmer, that same sparkle, that same sort of tone. Something, I can't describe it, where there's fear...

Rewiring the Brain for Thyroid Recovery with Dr. Patrick Porter What if you could train your brain to help your thyroid recover? In this episode, Dr. Eric Balcavage sits down with Dr. Patrick Porter, creator of BrainTap®, to explore how brainwave training, stress regulation, and nervous-system balance can unlock your body's natural healing potential. In this conversation: How chronic stress keeps the brain stuck in "danger mode" and blocks thyroid recovery Why the amygdala, HPA axis, and thyroid are part of one continuous feedback loop The role of neuroplasticity and brainwave entrainment in calming the body's stress response Practical tools to shift from survival to safety mode—naturally How BrainTap supports sleep, energy, focus, and overall metabolic balance

In this thought-provoking episode of the Nutritional Therapy and Wellness Podcast, host Jamie Belz, sits down with fellow FNTP, Patti McCoy, Assistant Instructor at the Nutritional Therapy Association and long-time adult educator, to unpack one of the most paradigm-shifting books on mental health today: Lost Connections by Johann Hari. What if depression and anxiety are not primarily caused by a chemical imbalance in the brain, but by a series of broken connections in our lives? Together, Patti and Jamie explore how this book, combined with their work in functional nutrition and the Foundations of Health, can completely reframe how we view mental health, burnout, and the endless "hustle and numb" culture so many of us are stuck in. Some Topics Touched on: Disconnection from meaningful work, other people, meaningful values, childhood trauma, status and respect, the natural world, etc., and how all of this shows up as very real symptoms in the body: depression, anxiety, chronic stress, poor sleep, blood sugar swings, and "feeling like a shell" of yourself Many people are told, "Your brain is broken, here's a pill," and are given an SSRI instead of being asked, "What happened to you—and when did this start?" How childhood trauma and ACEs (Adverse Childhood Experiences) can shape the HPA axis, stress response, food relationships, and long-term health The impact of intergenerational trauma, and how science now shows that stress imprints can be passed down biologically through both mother and father The "dash lights" on your body's dashboard and why symptoms (including nausea, anxiety, insomnia, low mood) are messages, not design flaws to be suppressed How screens, constant notifications, and the pressure to respond to everyone all the time are quietly eroding our capacity for deep connection, quiet, and repair Coping mechanism: alcohol, sugar, shopping, scrolling, gaming, pornography, or Netflix - and how these become nurseries for more trauma and disconnection How the Foundations of Health: digestion, blood sugar regulation, a nutrient-dense diet, sleep, stress management, hydration, and movement - create the biological stability we need to heal Marriage and relationships in the age of screens – the difference between being in the same room and actually being together The loneliness of remote work and why some of us didn't realize how much we needed daily in-person interaction until it was gone The loss of third spaces and micro-communities after COVID Why "busy" has become a bizarre badge of honor, and how Distraction Detox and intentional boundaries around technology can restore sanity and presence Resources Mentioned: Book – "Lost Connections: Uncovering the Real Causes of Depression – and the Unexpected Solutions" by Johann Hari Book – "Molecules of Emotion: The Science Behind Mind–Body Medicine" by Candace B. Pert, PhD Book – "Childhood Under Siege" by Joel Bakan   Nutritional Therapy Association (NTA) Nutritional Therapy Practitioner (NTP) program PHWC program (Professional health/wellness certification track referenced in the episode) NTA – Foundations of Healing Course A course for anyone who wants to understand and apply the Foundations of Health: nutrient-dense diet, digestion, blood sugar, stress, and sleep NTA Health The clinical arm of the Nutritional Therapy Association, offering care rooted in foundational, root-cause principles JOIN A WEBINAR to Learn More!   Episode 4: Bio-Individuality Episode 21: STRESS!!! How It Impacts Your Brain and Body Distraction Detox Series: Ep 51: Death By Distraction - Rewire Your Rhythms, Restore Your Health Ep 52: The Hidden Health Cost of Distraction Ep 55: Distraction Detox - Dizzy Busy and Dying Inside Ep 56: Distraction Detox - Cluttered Spaces, Cluttered Brains Ep 57: Distraction Detox - THE MONSTER (Jamie's Favorite) Ep 58: Distraction Detox - Live Immediately   Follow, leave reviews, and comment directly on Spotify. We love hearing from you!

Our Co-Heads of Securitized Product Research Jay Bacow and James Egan discuss the outlook for mortgage rates and the U.S. housing market in 2026.Read more insights from Morgan Stanley.----- Transcript -----Jay Bacow: Jim, why did the cranberry turn red? James Egan: Please enlighten me. Jay Bacow: Because it saw the turkey dressing. Jay Bacow: I hope everybody had a good Thanksgiving. Welcome to Thoughts on the Market. I'm Jay Bacow, Co-Head of Securitized Products Research at Morgan Stanley. James Egan: And I'm Jim Egan, the other Co-Head of Securitized Products Research at Morgan Stanley. Today we're here to talk about our views from mortgage rates in 2026 and how that flows through to our U.S. housing outlook.It's Monday, December 1st at 11:30am in New York.Now, Jay, as we all get over our turkey induced naps over the weekend, how are we thinking about mortgage rates evolving in 2026?Jay Bacow: Well, as you and I discussed previously on this podcast, the Fed cutting rates in and of itself doesn't actually cause the 30-year fixed rate mortgage to come down. However, our rate strategists' forecast for lower rates in the front end should be helpful to where the primary rate ends up this year. And we would also expect some compression between primary mortgage rates and Treasury rates given our bullish outlook for the mortgage asset class. So, our expectation is that the 30-year fixed rate ends 2026 around 5.75 percent.James Egan: Alright, if we get to 5.75, maybe a little bit lower than that in the middle of next year, that's enough to send affordability into a healthier place. But that's a relative term. Affordability is still going to be under pressure, but it will have improved. And it will have improved at a pretty healthy amount from where we were in the fourth quarter of 2023, which was multi-decade levels of challenged.Jay Bacow: All right, Jim, so clearly the mortgage rate coming down does make homes more affordable, but is it enough to cause more homes to actually transact?James Egan: So, the answer is yes, but it's going to be a ‘Yes, but' answer from that perspective. We do think that transaction volumes are going to increase. But to put into context where we sit from a housing market perspective – we already saw a healthy increase in affordability from the fourth quarter of [20]23 through the end of 2024, right? But if we put that affordability improvement in context, we've seen that about 10 times over the past 40 years. The only times where sales responded more tepidly than they just did in 2025 – were in 2009, the teeth of the Great Financial Crisis; and in 2020, when the market really slowed down in the immediate aftermath of COVID. The lock-in effect is still playing a very big role. We do think that this sustained marginal improvement and affordability will help purchase volumes. But this is not what's going to get us to kind of escape velocity. We're calling for about a 3 percent growth in purchase volumes next year. Jay Bacow: Alright. Now, you mentioned this a little bit already, but if there's less lock-in because the mortgage rate has come down, will more people be willing to list their homes for sale? Are we going to get more inventory on the market? James Egan: I think that's the other piece of how we're thinking about housing moving forward. Any improvement we get in affordability from lower mortgage rates is going to be paired with increasing inventory volumes. We've already seen that. Listed inventories are up roughly 30 percent from historic lows in 2023. They're still 20 percent worth below where they were in 2019. So, we're not talking about oversupply at this point. But that increase in listed inventories without a contemporaneous increase in demand is weighed on the pace of home price growth. We started this year at +4 percent nationally. We're below +1.5 percent. We think that any growth and demand will come coincident with the growth in listing volumes. That's going to keep home price appreciation under control. We're only calling for 2 percent growth in HPA next year, 3 percent out in 2027. But the high level thought here is that the housing market is well supported at these levels. Difficult to see big decreases in sales volumes or prices next year. But also going to be difficult to really achieve any more material growth in this low single digits we're calling for. But Jay, as you and I are talking about this outlook with market participants, one question that gets brought up frequently is what else can the administration do, especially on the affordability side, to help with instigating more housing activity. Jay Bacow: In order to really help affordability, given the challenges that you've discussed around the supply and demand issues; then the other aspect of that is just what is the mortgage rate? And if they were to do things that would cause the mortgage rate to come down, that would be helpful. Now, the Fed already has made an announcement that they're going to continue mortgage runoff from their balance sheet. If they ended mortgage runoff, that would've helped. But that window seems to have passed. There's been some discussion from the administration around new types of programs. In particular, there was a lot of headlines around a 50-year program. A 50-year amortization schedule would likely result in a material drop in the monthly payment that the homeowner would make – which would help. However, the total interest payments for that homeowner, depending on exactly where this hypothetical 50-year mortgage rate would price, are probably about double over the life of the loan relative to a 30-year fixed rate mortgage. So, we're not really sure that this product would see a huge amount of upkeep. There's also some technical challenges around whether it meets the definition of a qualified mortgage and some other in the weeds discussions. James Egan: What about all the discussion we're hearing around assumability of mortgages, portability of mortgages? Is there anything there? Jay Bacow: Based on our understanding of contract law, which I have to confess is limited as I am not a lawyer, we don't think you can retroactively make mortgages portable or assumable that were not already portable or assumable. So, you can make new mortgages portable and assumable. Portable as a reminder means that if you have a mortgage, you take it with you to your new house, and assumable means that the mortgage stays with the house. If you sell it to somebody else, they get that mortgage. But realistically, we think this would have to be a new product. And because it would be a new product with new benefits to the homeowner, it would actually probably cause their mortgage rate to be higher, not lower. James Egan: I guess one last question. We're talking about affordability and we're addressing it through interest rates being lower, we're addressing it through the potential for new products to be put out there, even if there are some challenges around that piece of it. But what about just demand for mortgages themselves? You said the Fed might not be a buyer going forward, but are there other pockets of demand for mortgages that could help bring down mortgage rates? Jay Bacow: Sure. So, we expect the GSEs to grow their portfolio next year, that would certainly be helpful. On the margin, we expect them to buy about a little less than a third of the net issuance that comes to the market. We also think that domestic banks could come back to the market and they could help bring the mortgage rates lower. But these changes are going to help mortgage rates by, in the context of maybe an eighth of a point to a quarter of a point at most. It's not a panacea, unfortunately. James Egan: Alright. So, we expect a little bit of an improvement in mortgage rates, a little bit of affordability improvement next year. That should lead to growth in purchase volumes, and I think it will lead to a little bit of growth in home prices. But the housing market is well supported range bound here. Jay Bacow: Jim, pleasure talking to you. And to all our regular listeners, thank you for adding Thoughts on the Market to your playlist. James Egan: Let us know what you think wherever you get this podcast and share Thoughts on the Market with a friend or colleague today.Jay Bacow: And as my kids would say, go smash that subscribe button.

In this episode, we're asking a hard question: Is stress actually making you sick?We break down what chronic stress actually does to your body, including the HPA axis (your body's “stress thermostat”), cortisol dysregulation, inflammation, immune suppression, messed-up sleep, digestive issues, brain fog, and that “wired but exhausted” feeling. We also talk about how stress stacks over time—work, finances, health scares, doomscrolling—and how it can quietly push you toward burnout, infections, and long-term health problems.You'll hear:How my stress and burnout set the stage for a serious infectionWhat the HPA axis is (in normal human language)Signs your body is too stressed (physical, mental, and behavioral)Why “I'm fine, it's just anxiety” is one of the biggest lies we tell ourselvesSmall, realistic things you can do this week to start lowering your stress loadThis isn't about getting rid of stress completely—that's impossible. It's about respecting what it does to your body and learning to manage it before your body forces you to.

Send us a textDownload the Chakras and Hormones Guide Here. Your gut isn't just digesting food—it's digesting your life story. We explore how early experiences shape the solar plexus, the body's center for will, confidence, and metabolism, and reveal why cravings, energy crashes, and “wired but tired” might be your nervous system asking for safety. With a blend of medical insight and gentle energy work, we map the path from survival to steadier energy, calmer digestion, and a kinder inner voice.We unpack what happens when childhood stress trains the HPA axis to live on high alert, how cortisol pushes glucose into the bloodstream, and why insulin struggles to keep up. Then we translate that science into daily tools: breathwork that warms the upper abdomen, Reiki to release stored shame, and journaling that reclaims the I can of early development. Along the way, we highlight the role of the kidneys and vitamin D in insulin sensitivity and mood, and explain how hydration, minerals, and sunlight rebuild your base so the solar plexus flame can hold steady.You'll leave with practical steps that actually fit real life: build meals that stabilize blood sugar, use magnesium and B vitamins to support nerves and adrenals, add 10 minutes of natural light to reset rhythms, and choose movement that grounds rather than exhausts. We close with a guided visualization and affirmations—It is safe for me to be seen, My power is gentle and grounded, I digest life with ease—so your body learns that nourishment and safety can coexist. If this conversation helps, subscribe, share it with someone who needs a kinder plan for healing, and leave a quick review so we can reach more listeners on this path.Welcome to the Art of Healing Podcast community. This podcast is devoted to helping you find what works on your journey to health and wellness. This podcast is devoted to providing information on many healing modalities. Learn more about:ReikiFunctional MedicineMeditationEnergy Healingand more!Learn more about Dr. Charlyce here. Never miss an episode of Art of Healing Podcast...the podcast devoted to helping you heal your mind, body and spirit.Sign up for my weekly newsletter, and never miss an episode along with other great content:Art of Healing PodcastStay in touch socially here:Healing Arts LinksLearn more about me and my offerings here:Healing Arts Health and Wellness

In this episode, Ben Azadi reveals how most people are using olive oil completely wrong — and how drinking high-quality extra virgin olive oil at the right time can melt belly fat, lower cortisol, reduce inflammation, and boost metabolic health in as little as one day. Ben explains the science behind olive oil's fat-burning power, including how it activates PPAR-alpha, improves GLP-1, stabilizes blood sugar, lowers insulin, and shuts down inflammation at the cellular level. He also breaks down how polyphenols like oleocanthal help regulate the HPA axis, improve sleep, boost autophagy, and enhance brain clarity. You'll learn the biggest mistakes people make with olive oil, why most store-bought oils are fake or oxidized, and why early-harvest, cold-pressed, high-polyphenol oil is essential. Ben shares his exact olive oil protocol, including: The morning fasted olive oil shot to lower cortisol How to pair olive oil with high-polyphenol foods When to take olive oil before meals for smaller glucose spikes How to use it at night or during 3 a.m. wake-ups His one-day “fat loss reset” using olive oil He also discusses why he personally uses the Fresh Pressed Olive Oil Club and offers his audience an exclusive “buy 2, get the 3rd free” link: http://benazadi.com/oliveoil  FREE GUIDE: 7-Day Fat-Burning Guide - https://bit.ly/4pnYoiB  This episode is a practical, science-backed guide for using one of the world's oldest superfoods as a metabolic medicine to burn fat, balance hormones, reduce stress, and improve longevity.

Episode Summary: In this episode of Grieve That Shit, Sharon Brubaker talks about something most grievers never see coming: why normal sounds suddenly feel like an attack. The kids laughing, the microwave door slamming, a choir starting at church, a car alarm in the parking lot. Things you used to handle just fine now hit your body like lightning. Sharon walks you through what is really happening inside your grieving brain. She breaks down the amygdala, the nervous system, the HPA axis, and why grief flips all of them into survival mode. This is not you "being dramatic." This is biology. Your brain is trying to protect your broken heart and it does not know the difference between emotional danger and physical danger. Through real stories from her clients, Sharon shows how jumpiness, noise sensitivity, snapping at people, and shutting down in crowds are not personality flaws. They are signs that your grief system is stuck on high alert and has not been taught how to turn off. Then she shows you the path out: learning how to calm your brain by processing the pain of grief instead of running from it. Key Points Discussed: Why everyday noise can feel like an attack when you are grieving How the amygdala scans for emotional pain and treats it like danger What happens to your thinking center when grief hits and why you feel numb How the sympathetic nervous system keeps your body in survival mode Why your senses feel sharper, your reactions bigger, and your patience thinner The four grief responses Sharon sees most often: resisting, reacting, avoiding, and pretending How stress hormones like cortisol and adrenaline keep your system on high alert Why this noise sensitivity is not permanent when you learn to process the pain How Processing the Pain of Grief helps calm your brain and soften your grief Journal Questions for Reflection: What sounds or situations make your body jump or tense up now that you are grieving Where do you notice your thinking has slowed down or feels foggy When was the last time you snapped or shut down and later realized you were not really mad at that person or thing What background noise or repeated behavior from others feels harder to tolerate since your loss What would it look like to give your brain and body a place to calm down instead of just pushing through Conclusion: Noise sensitivity in grief is not you "losing it." It is your grief biology doing its best to protect you with the only tools it knows. Your brain is on high alert. Your body is tired. Your system is trying to outrun the pain. But this does not have to be your forever. When you learn how to process the pain of grief, your nervous system can settle. Your thoughts get clearer. Your reactions soften. The world gets a little quieter again. You will still miss your person, but the grief does not have to feel like an attack every time a memory or a sound shows up. Contact Us: Ready to calm your grief brain and learn how to process the pain, not just survive it Join Sharon Brubaker inside Processing the Pain of Grief, her live classroom where you learn what your brain is doing, how grief works in the body, and how to move the pain out instead of holding it in. Learn more and get support inside The Grief School community. Website: thegriefschool.com Contact: info@thegriefschool.com TikTok, YouTube, Instagram: @thegriefschool

Send us a textEver notice how the harder your mind works, the less your body feels like home? We dig into why relentless thinking tricks your brain into sounding a constant danger alarm, how that message hits the HPA axis, and why your root chakra interprets it as “I'm not safe.” You'll learn how this loop fuels anxiety, fatigue, restless sleep, and sugar cravings, plus the grounded practices that bring your energy back where it belongs.Learn more about the HPA axis, Hormones and Chakras in this free resource:Chakras and HormonesWe begin by reconnecting with the body through simple breath and awareness, then map the physiology: the hypothalamic-pituitary-adrenal pathway, cortisol and DHEA rhythms, and the way chronic worry keeps the nervous system on high alert. From there, we translate the science into daily tools. Five accessible grounding practices form the core of this episode—barefoot time or visualization of roots, warm and stabilizing foods like root vegetables and quality protein, a 4-2-6 breath cadence to ease the system into rest and digest, gentle yoga moves like mountain pose you can do anywhere, and practical guidance on when to test salivary cortisol and DHEA to validate what you're feeling.You'll hear examples of stress “hot hours,” body check-ins that take under two minutes, and a calming phrase to re-teach safety to the lower brain. We also share options for energy support, from brief Reiki resets to a free 90-minute Harmonize Your Energy workshop with downloadable guides. The goal is simple: stop living from the neck up and reclaim steadiness from the spine down so thought, feeling, and action move in the same direction.If this helped you feel more grounded, follow the show, share it with a friend who's running on fumes, and leave a quick review. Want to join us live and get resources in your inbox? Tap the link in the show notes to join the newsletter.Welcome to the Art of Healing Podcast community. This podcast is devoted to helping you find what works on your journey to health and wellness. This podcast is devoted to providing information on many healing modalities. Learn more about:ReikiFunctional MedicineMeditationEnergy Healingand more!Learn more about Dr. Charlyce here. Never miss an episode of Art of Healing Podcast...the podcast devoted to helping you heal your mind, body and spirit.Sign up for my weekly newsletter, and never miss an episode along with other great content:Art of Healing PodcastStay in touch socially here:Healing Arts LinksLearn more about me and my offerings here:Healing Arts Health and Wellness

Do you immediately reach for coffee in the morning just to feel human or have afternoon crashes by 2 PM? This episode is for you.  Today in The Wellness Effect, we're diving into adrenal fatigue—or more accurately, HPA axis dysregulation—and why that exhausting cycle isn't just "normal adulting." We'll unpack what's actually happening when your stress system's alarm has been blaring for so long that the batteries finally died. Whether you're stuck in the "tired but wired" cycle, convinced you just need more willpower, or wondering why every small inconvenience feels like a major catastrophe, this conversation will completely shift how you understand energy, stress, and what your body actually needs to function.   In this episode, you'll hear: [00:33] - The real signs you're dealing with adrenal fatigue beyond just feeling tired [20:36] - What your adrenals actually do and the critical hormones they produce [23:40] - The stages of HPA axis dysfunction: from high cortisol to completely bottomed out [25:13] - How adrenal dysfunction affects your thyroid, sex hormones, blood sugar, and immune system [28:40] - What quitting caffeine reveals about your adrenal health [31:05] - What the HTMA test reveals about adrenal function through mineral patterns [32:30] - The exhaustive symptom checklist [37:13] - Nutrition fixes: why undereating and skipping breakfast destroy your adrenals [41:11] - Sleep requirements for women. Seven hours isn't enough! [43:18] - When training is destroying your adrenals [43:52] - Stage four HPA axis dysfunction: when rest is the only cure [46:26] - Supplement supports: magnesium, vitamin C, B vitamins, and adaptogens [50:57] - The productivity mindset shift: reframing what "productive" actually means   Key Takeaways: Your adrenals produce critical hormones including cortisol, adrenaline, DHEA, and more—they regulate stress response, metabolism, blood pressure, immune function, and sex hormones HPA axis dysregulation happens in stages: you start with high cortisol from chronic stress, then eventually your body can't keep up and cortisol crashes—that's when you really feel the exhaustion Rest isn't lazy, it's the most productive thing you can do for long-term health—schedule it like an appointment and don't miss it   Want more from us? Visit our website: https://www.lifestyleucoaching.ca/ Follow us on Instagram: @wellnesseffectpod Lacey Iskra - @laceeiskk Jensen - @wellnesswjensen Kira Iskra - @kiraiskk Lifestyle U have helped over 1,000+ women transform their mind and body and become the best version of themselves. Want to be next? Click Here to Apply! - https://www.lifestyleucoaching.ca/apply If you loved this episode and want to hear more, subscribe and leave a review! Share this episode with a friend who's ready to start their own wellness journey. Follow us on Instagram at @wellnesseffectpod to stay up-to-date with the latest episodes and tips.  

In this essential episode, Trina Renea and Rebecca Gadberry explore the science behind stressed skin and why your favorite products might suddenly stop working during stressful periods. Learn about the HPA axis connection between your brain and skin, how cortisol and norepinephrine damage your skin barrier, and why stress effects can linger long after the stressful event ends. Discover the power of oxytocin—the "love hormone"—and simple techniques like specialized breathing and facial massage that trigger it. Rebecca shares game-changing ingredients like Helichrysum italicum, niacinamide, and aloe vera that help repair stressed skin. Estheticians will gain practical protocol adjustments for treating stressed clients, while consumers learn at-home strategies to support their skin through the holidays and beyond. This episode reframes skincare as wellness, not luxury.

Learn how to restore your adrenal function and reclaim your energy with this comprehensive 90-day reset plan. Nurse Doza maps out a practical approach to reversing adrenal fatigue through measurable testing (DHEAS and HRV), lifestyle modifications including belly breathing and sunlight exposure, and targeted supplementation to support your body's stress response and energy production. Character count: 394 5 KEY TAKEAWAYS Measure Your Adrenal Function: DHEAS blood testing (optimal range: 200-250) provides a stable measurement of adrenal function over time without daily variation, while Heart Rate Variability (HRV) tracks your recent stress response and nervous system health in real-time. Activate Rest and Digest Mode: Belly breathing (diaphragmatic breathing) actively shifts your nervous system from fight-or-flight to rest-and-digest mode by increasing parasympathetic activity, lowering cortisol levels, and improving HRV with just 4-7 minutes daily. Morning Sunlight Resets Your System: Getting sunlight within the first hour of waking naturally boosts cortisol production, increases serotonin synthesis, provides vitamin D, and sets your circadian rhythm for better sleep—aim for 30-45 minutes of direct sunlight without sunglasses. Support with Targeted Nutrition: Bovine adrenal gland extracts provide building blocks for your own adrenal glands to resume normal function, a practice used successfully since the early 1900s, while B vitamins (especially B5 and B6) help regulate cortisol production and support energy metabolism. Address Underlying Trauma: Unresolved trauma from childhood or adulthood chronically activates your stress response and suppresses adrenal function—addressing it through therapies like CBT, EMDR, or somatic experiencing is essential for long-term adrenal recovery and nervous system regulation. FEATURED PRODUCT Zen – featuring bovine adrenal gland extracts, is designed to support adrenal function and help regulate cortisol production—key factors in restoring energy and recovering from burnout as discussed in this episode. The bovine adrenal gland provides the building blocks for your own adrenal glands to resume normal function, while B vitamins (especially B5 and B6) support healthy stress response. Zen is the gentle, targeted support your adrenals need during this 90-day reset. Shop Zen TIMESTAMPS 00:00 – START – Welcome and episode overview 02:15 – Understanding adrenal glands beyond traditional teaching 05:30 – Common symptoms of adrenal dysfunction and chronic fatigue 08:45 – First 30 days: Measuring DHEAS blood test for adrenal function 12:20 – Understanding Heart Rate Variability (HRV) for stress monitoring 16:40 – Optimal ranges for DHEAS and HRV measurements 20:15 – Days 31-60: Switching from fight-or-flight to rest-and-digest 23:50 – Belly breathing (diaphragmatic breathing) technique explained 27:30 – Legs on the wall yoga pose for nervous system reset 31:10 – Morning sunlight exposure and circadian rhythm 35:20 – Days 61-90: Zen supplement with bovine adrenal gland and B vitamins 40:45 – Making sleep a priority throughout the reset 44:20 – Addressing trauma for long-term adrenal recovery 47:00 – 90-day plan recap and final recommendations RESOURCES Mayo Clinic: Adrenal Fatigue – Overview of adrenal fatigue as a general term for symptoms like tiredness, weakness, and sleep problems https://www.mayoclinic.org/diseases-conditions/addisons-disease/expert-answers/adrenal-fatigue/faq-20057906 DHEA Potent Effects on Cytokine Production – Research on DHEA's anti-inflammatory effects and IL-2 synthesis https://www.sciencedirect.com/science/article/abs/pii/S0083672918300347?via%3Dihub DHEA-S vs DHEA: Brain Health – Explains why DHEA-S doesn't exhibit diurnal rhythm and is more stable for testing https://www.zrtlab.com/blog/archive/difference-dhea-dheas-brain-health Neuroendocrine and Immune System Communication – Study on DHEA, inflammation, infection, and the HPA axis https://pmc.ncbi.nlm.nih.gov/articles/PMC9207529/ Heart Rate Variability and Mortality – Research showing low HRV predicts mortality, morbidity, depression, anxiety, and chronic stress https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575449/ Fight-or-Flight Response Overview – Comprehensive guide to autonomic nervous system stress response https://positivepsychology.com/fight-or-flight-response/ Diaphragmatic Breathing Benefits – Study showing DB reduces respiratory rate and salivary cortisol levels https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602530/ VA: Diaphragmatic Breathing and HRV – Veterans Affairs resource on how diaphragmatic breathing increases heart rate variability https://www.va.gov/WHOLEHEALTHLIBRARY/tools/diaphragmatic-breathing.asp Health Effects of the Sun and Vitamin D – Article on morning light exposure and circadian rhythm https://www.businessinsider.com/health-effects-of-the-sun-and-vitamin-d-2014-6 Morning Sunlight Exposure Benefits – Guidelines for optimal morning light exposure (30-45 minutes within first hour) https://www.verywellhealth.com/morning-sunlight-exposure-3973908 Music with Binaural Beat Therapy – Study on sympathetic/parasympathetic responses https://pubmed.ncbi.nlm.nih.gov/28544507/ Whole Body Vibration and HRV – Research on WBV improving heart rate variability https://pubmed.ncbi.nlm.nih.gov/30100286/ Glandular Therapies for Modern Challenges – Overview of how adrenal glandulars provide building blocks for adrenal function https://www.clinicaleducation.org/news/glandular-therapies-an-age-old-solution-for-modern-challenges-and-chronic-disease/ Historical Use of Adrenal Glandulars – Dr. Isaacs research on Merck's 1905 Manual and bovine adrenal content https://pmc.ncbi.nlm.nih.gov/articles/PMC10289114/ Heart Rate Variability and Nighttime – Study showing HRV is typically higher during nighttime https://www.ahajournals.org/doi/full/10.1161/01.cir.91.7.1918 Early Evening Light and Sleep – Research on how light timing affects sleep quality https://www.nature.com/articles/s41598-019-52352-w Melatonin and Happiness Levels – Study on relationship between melatonin, cortisol, and mood https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449495/ Melatonin and Adrenal Glands – Research on melatonin's role as endogenous pacemaker for adrenal function https://www.ncbi.nlm.nih.gov/sites/books/NBK550972/ MSW Nutrition Zen Supplement – Bovine adrenal gland with B5 and B6 for adrenal support https://www.mswnutrition.com/products/zen Nursedoza.com – Book a consultation for adrenal testing and personalized protocols http://www.nursedoza.com/ CONNECT

If you've been told you have premature ovarian insufficiency (POI), it can feel final as if your ovaries have stopped working and your only hope is donor eggs. But the truth is more complex. Research shows that spontaneous ovulation is still possible. In this episode, we're looking at POI through both a conventional and functional fertility lens, exploring what it really means for your pregnancy potential, and how timing, preparation, and immune balance all matter. You'll learn: The difference between menopause and POI and why ovarian function can "flicker" back on What autoimmune activity, gut health, and toxins have to do with ovarian function The realistic chances of natural pregnancy with POI and how to detect spontaneous ovulation When hormone therapy or IVF with your own eggs might make sense Why donor eggs often lead to high success rates when functional foundations are addressed Sarah Clark is the founder of Fab Fertile Inc. and the host of Get Pregnant Naturally. Her team specializes in functional approaches for low AMH, high FSH, diminished ovarian reserve, premature ovarian insufficiency, recurrent miscarriage and helping couples prepare their bodies for pregnancy success naturally or with IVF. This episode is especially for you if: You've been told POI or "early menopause" means you'll never get pregnant You're considering IVF or donor eggs and want to understand your options You want a clear, functional fertility plan to prepare your body for pregnanc ·     Not sure where to start? Download our most popular resource: The Ultimate Guide to Getting Pregnant This Year If You Have Low AMH/High FSH. It breaks everything down step by step to help you understand your options and take action. ·     For personalized support to improve pregnancy success, book a call here. --- TIMESTAMPS  00:00 — The truth about POI and pregnancy POI isn't always the end of the road. Learn how spontaneous ovulation and functional fertility preparation can open new possibilities even after a diagnosis of premature ovarian insufficiency. 01:00 — What POI really means (and how it differs from early menopause) Conventional vs functional views of ovarian function — why "flickering" ovarian activity matters for pregnancy potential. 02:30 Underlying imbalances behind POI How autoimmune issues, gut dysfunction, toxins, and stress affect ovarian function and fertility outcomes. 04:00 Realistic chances of pregnancy with POI Research-backed data showing 5–10% of women with POI conceive naturally, plus factors that improve success rates. 06:00 Spontaneous ovulation and how to catch it Tracking methods like Mira, Inito, and PDG tests that can help you detect rare ovulations and time intercourse or IVF cycles effectively. 08:00 Managing stress and nervous system regulation Why chronic stress and HPA-axis dysfunction shut down ovulation and how the nervous system work restores reproductive signaling. 10:00 Gut, immune, and environmental testing for POI Why stool, food sensitivity, and mycotoxin testing matter for egg quality, implantation, and autoimmune balance. 12:00 Nutrients and mitochondrial support for egg quality How CoQ10, magnesium, selenium, vitamin D, and omega-3s support ovarian function and improve outcomes. 15:00 IVF with your own eggs and donor egg options When IVF may still work for women with POI, and how to prepare your body functionally before considering donor eggs. 18:00 Hope and next steps for POI and fertility Why POI doesn't mean no chance from spontaneous ovulation to IVF and donor eggs, discover how health-first strategies improve success. --- RESOURCES ·        

A lot of “natural” stress aids aren't harmless—because they actually work. In this Mini Mikipedia, Mikki breaks down how popular adaptogens and nutrients interact with your HPA axis (the body's stress-response command centre) and when that's a blessing versus a blind spot. You'll learn what the evidence says for ashwagandha, rhodiola, holy basil, phosphatidylserine, and why liquorice root is uniquely risky. Mikki covers dose ranges used in studies, who should be cautious (thyroid issues, pregnancy/breastfeeding, low cortisol, meds), how to test cortisol properly, and why cycling supplements beats “more is better.” She also revisits the basics that move the needle—sleep, protein-centred meals, training balance, boundaries, and connection—so supplements can supplement a solid plan, not replace it.HighlightsHow HPA axis modulation can help—or hinder—stress recoveryLiquorice root and pseudoaldosteronism: real risks, not theoryPhosphatidylserine blunts cortisol; context and cycling matterRhodiola and holy basil: mixed/early evidence, variable extractsTesting (4-point saliva, timing), interactions, and quality assurance Contact Mikki:https://mikkiwilliden.com/https://www.facebook.com/mikkiwillidennutritionhttps://www.instagram.com/mikkiwilliden/https://linktr.ee/mikkiwillidenSave 20% on all Nuzest Products WORLDWIDE with the code MIKKI at www.nuzest.co.nz, www.nuzest.com.au or www.nuzest.comCurranz supplement: MIKKI saves you 25% at www.curranz.co.nz or www.curranz.co.uk off your first order

Episode Title: Developing Resilience in High-Pressure SituationsSummaryWelcome back to the Muscles & Mindset Podcast with Dr. Ali Novitsky, board-certified obesity medicine physician and expert in stress, strength, and self-regulation.In this episode of the Stress Series, Dr. Novitsky explores how to build true resilience—not in serene environments, but in the moments that truly test us. Whether you're navigating life-or-death emergencies or emotionally charged situations, this conversation reveals how to stay centered and in control, even when your nervous system wants to panic.Using a powerful varicose vein metaphor, she explains how chronic stress is like a “leaky valve”—unless you address the root cause (emotional dysregulation), surface-level fixes like better habits won't stick. The solution? A simple pause.Dr. Novitsky teaches how a 2–3 second pause in the heat of stress can stop the brain's “hijack” and activate the prefrontal cortex—our reasoning center. She breaks down three stress scenarios and guides listeners toward the third, most empowering one: awareness, presence, and intentional breath.Drawing from cognitive behavioral therapy (CBT) and dialectical behavioral therapy (DBT), Dr. Novitsky offers a toolkit for regulating emotions, accessing your “wise brain,” and debriefing after stressful moments to rewire your response. Whether in medicine, sports, family dynamics, or everyday life, this episode shows how resilience can be learned—and why it's the key to long-term transformation.Key Points• Beyond the Spa: Real resilience is built in chaos, not calm.• The Leaky Valve Analogy: Fix emotional dysregulation at the root for lasting stress relief.• Stress Is Automatic: The fight-or-flight response can't be stopped—but it can be reshaped.• The Power of the Pause: A brief, intentional check-in prevents spiraling and restores clarity.• Three Stress Scenarios: 1. Hijacked and unaware. 2. Aware but suppressing. 3. Aware and present—the goal.• Tools from CBT & DBT: Learn to regulate emotions and access clear, productive thinking.• Debrief to Rewire: Reflecting after stress creates new mental pathways for resilience.• Lifelong Practice: Emotional regulation isn't a finish line—it's a daily skill worth mastering.Timestamps• 00:02 – Intro: Managing real-world stress• 02:10 – The “leaky valve” analogy for chronic stress• 04:00 – Understanding the HPA axis and stress physiology• 05:40 – Prefrontal cortex hijacking: why we spiral• 07:10 – The pause as a regulation tool• 09:30 – Scenario breakdown: hijack, suppression, or presence• 11:50 – Staying calm in acute stress (e.g., medical emergencies)• 13:40 – Building confidence by staying grounded• 15:00 – Personal story: trauma and resilience in college athletics• 18:20 – CBT vs. DBT: how emotions shape thoughts• 21:40 – Tools for distress tolerance and “wise mind”• 24:40 – Personal debriefs: your secret weapon for growth• 27:40 – Real-life triggers and emotional awareness• 30:10 – Transform 10: a year-long stress mastery programFollow Dr. Ali Novitsky on TikTok | Facebook | Instagram | YouTubeSubscribe to the Muscles and Mindset Podcast on Spotify | Apple PodcastsWork with Dr. Ali

Send us a textYour postpartum clients aren't just "busy"—they're breaking down. Here's the truth your assessments are missing: The invisible mental load is a chronic state of cognitive overload that's hijacking her body. This isn't a failure of willpower; it's a physiological response to chronic stress that causes everything from unexplained anxiety and low milk supply to pelvic pain and insomnia. Maranda reveals how this unacknowledged cognitive burden triggers the HPA axis, shuts down nervous system regulation, and creates a cascade of physical symptoms. Every postpartum provider—from lactation consultants to functional health experts—must recognize this root cause. Stop treating the symptoms (the fatigue, the rage, the anxiety) and start addressing the overload. Learn the red flags and the Postpartum Restoration Method framework to deliver the lasting solutions your clients desperately need.Check out the episode on the blog HERE: https://postpartumu.com/podcast/the-invisible-mental-load-why-mothers-are-breaking-down-ep-238/Key time stamps: 1:03 -  Defining The Invisible Mental Load & The Shocking Case of Low Milk Supply3:33 - The Physiology of Cognitive Overload: HPA Axis and Systemic Effects6:53 - Clinical Patterns Providers Miss: The Hyper-Vigilant Manager, Overwhelmed Perfectionist, and Depleted Default Parent9:37 - Pelvic Floor Tension & The Bonding "Disconnection"22:15 - The Red Flags and "Better Questions" for Assessment NEXT STEPS:

Join the fx Medicine by BioCeuticals ambassadors, Emma Sutherland, Lisa Costa-Bir and Mick Alexander, hosted by Dr Adrian Lopresti, face-to-face, for an intimate discussion. Hosted by Dr Adrian Lopresti, clinical psychologist and researcher, this panel will explore the key elements of optimal brain health - going beyond theory into practical insights you can apply in clinic straight away. Our ambassadors bring decades of front-line experience and will share their top clinical pearls on brain health from multiple, integrative perspectives: - Lisa Costa-Bir (naturopath, nutritionist & women's health expert) explores movement as “brain medicine” to slow cognitive decline, while referring to Dr Helena Popovic's work on "Adventure prevents dementia". - Mick Alexander (integrative pharmacist & naturopath) breaks down the gut-brain and HPA axis plus overlooked medication nutrient depletions. - Emma Sutherland (naturopath & women's health expert) discusses hormones, “meno brain” and her top therapeutics. Enjoy the recording which our live audience described as "not only informative but joyful to watch", very insightful information backed by studies, gave real life examples", and "clinically relevant and practical". Don't miss out on our first ever live panel discussion. Held in collaboration with @ATMS. Covered in this episode (01:57) Key elements of optimal brain health: An overview of what makes a healthy brain? (Dr Adrian Lopresti) (10:30) Adventure prevents dementia: Practical strategies to add to you toolkit - novel activities, grip strength, tongue exercises to increase brain size (Lisa Costa-Bir) (35:00) Pharmaceutical drugs & the impact to the gut-brain axis: The significant impacts and potential therapies to maintain the gut-brain connection (Mick Alexander) (58:20) Hormones & brain function: Optimise women's brain health in perimenopause and menopause (Emma Sutherland) DISCLAIMER: The information provided on fx Medicine by BioCeuticals is for educational and informational purposes only. The information provided on this site is not, nor is it intended to be, a substitute for professional advice or care. Please seek the advice of a qualified health care professional in the event something you have read here raises questions or concerns regarding your health.

Muscles & Mindset Podcast with Dr. Ali Novitsky, MDStress Types & Relationships Series Episode 01: Understanding Stress as a Signal, Not a FailureWelcome to a brand-new season of Muscles & Mindset! After a revitalizing summer spent in Japan and Portugal, Dr. Ali Novitsky, board-certified obesity medicine physician and strength expert, kicks off a powerful 12-part series on stress—what it really is, how it shows up in the body, and why it's not a personal failing.In this episode, Dr. Novitsky reframes stress as a physiological signal, not a flaw. You'll learn the science behind the HPA axis, the real impact of chronic cortisol, and how simple practices like breathwork, strength training, and time in nature can help you regulate and thrive. Plus, she teases a free stress-type quiz coming in the next episode to help you personalize your approach.

Wrinkles are just the surface. This episode reveals what's really happening beneath your skin and how to reverse it using stem cells, regenerative medicine, and the most advanced techniques in plastic surgery and aging. You'll learn how to improve facial skin tightening, reduce inflammation, and trigger deep skin rejuvenation with stem cells, red light therapy, and targeted procedures that actually work. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey shares his personal journey through weight loss and skin excess, including why he had 28 inches of skin removed and how he rebuilt facial structure using stem cells and longevity protocols. He's joined by Dr. Victor Urzola, a globally recognized expert in plastic surgery and aging, known for pioneering biohacking skin health techniques, cutting-edge facial reconstruction, and legalizing therapeutic stem cell use in Costa Rica. Together, they expose the hidden causes of wrinkles and aging, from mitochondrial slowdown to ligament laxity and collagen depletion. They also unpack the science behind breast implant health risks, silicone toxicity syndrome, and why thousands of women experience hormonal, neurological, and metabolic symptoms related to their implants. Dr. Urzola explains how explant surgery can improve hormone balance, sleep, HRV, metabolism, and even libido. You'll also hear how cosmetic procedures interact with HPA axis function and how skin and brain health are more connected than you think. This episode is a must for anyone serious about biohacking, skin optimization, stem cells and longevity, and functional medicine. Dave also breaks down his recovery stack, including exosomes, red light therapy, collagen cycling, nootropics, and how cosmetic procedures can be used to enhance—not just appearance—but total human performance. You'll learn: • The real root causes of wrinkles and sagging skin • How to use skin rejuvenation with stem cells for long-term results • Signs of silicone toxicity syndrome and what to do about it • Why cosmetic procedures impact hormone health and libido • The most effective strategies for facial skin tightening and recovery• How to approach breast implant health risks with functional medicine thinking Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. SPONSORS: Generation Lab | Go to https://www.generationlab.com/ use code Dave20 for $20 off. Qualia | Go to https://www.qualialife.com/dave15 to get an additional 15% off subscriptions. fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order. Resources: • Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Dr. Urzola's Website: https://drvictorurzola.com/en/ • Danger Coffee: https://dangercoffee.com • Dave Asprey's Website: https://daveasprey.com • Dave Asprey's Linktree: https://linktr.ee/daveasprey • Upgrade Labs: https://upgradelabs.com • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 Trailer • 01:39 Intro • 02:52 Breast Implants & Aesthetics • 03:40 Stem Cells in Cosmetic Procedures • 10:38 Skin Health & Anti-Aging Tips • 15:11 Red Light & Face Stimulation • 17:15 Platysma Muscle & Neck Aging • 21:01 Implant Risks & Reactions • 27:36 Vince & Longevity Science • 28:51 Implant Tolerance Explained • 29:52 Silicone Health Impact • 31:06 Inflammation & Genetics • 32:15 Explant Outcomes & Recovery • 40:14 Breastfeeding & Aesthetic Changes • 41:03 Lift vs. Implants • 45:39 Patient-First Medical Care • 53:32 Stem Cells & Medical Freedom • 56:21 Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.