Podcasts about HPA

What goes on at the neurobiological level that makes someone more vulnerable to self-injure or self-harm? What biological risk factors are at play? What roles do the vagus nerve, cortisol levels, and hypothalamic-pituitary-adrenal (HPA) axis have? We hope to discuss the psychology of self-injury pain in a future episode, but in this episode, Dr. Michael Kaess from the University of Bern in Switzerland explains the neurobiology of self-injury in simple terms, or what we hope can be considered simple layman's terms.  Learn more about Dr. Kaess and his research team at the Universitäre Psychiatrische Dienste (UPD) in Bern here. To participate in Dr. Kaess' research study of an online intervention for self-injury (in German), visit the STAR (Self-injury Treatment Assessment Recovery) Project at https://star-projekt.de/. Below are links to some of the research referenced in this episode: Kaess, M., Hooley, J. M., Klimes-Dougan, B., Koenig, J., Plener, P. L., Reichl, C., Robinson, K., Schmahl, C., Sicorello, M., Schreiner, M. W., & Cullen, K. R. (2021). Advancing a temporal framework for understanding the biology of nonsuicidal self-injury: An expert review. Neuroscience and Biobehavioral Reviews, 130, 228-239. Reichl, C., Heyer, A., Brunner, R., Parzer, P., Völker, J. M., Resch, R., & Kaess, M. (2016). Hypothalamic-pituitary-adrenal axis, childhood adversity and adolescent nonsuicidal self-injury. Psychoneuroendocrinology, 74, 203-211. Plener, P. L., Bubalo, N., Fladung, A. K., Ludolph, A. G., & Lulé, D. (2012). Prone to excitement: Adolescent females with non-suicidal self-injury (NSSI) show altered cortical pattern to emotional and NSS-related material. Psychiatry Research, 203(2-3), 146-152. Follow Dr. Westers on Instagram @DocWesters. To join ISSS, visit itriples.org and follow ISSS on Facebook and X/Twitter (@ITripleS). The Psychology of Self-Injury podcast has been rated #5 by Feedspot in their "Best 20 Clinical Psychology Podcasts" and by Welp Magazine in their "20 Best Injury Podcasts."

Why does your brain feel like it's working against you when you're depressed? In this episode, licensed marriage and family therapist Kati Morton answers deep viewer questions to unpack what is actively happening in the body and brain during depressive episodes and periods of suicidal ideation. We challenge the traditional "chemical imbalance" framework to look at the modern science of mental health: how different regions of the brain communicate, why your HPA axis can get stuck in a chronic stress response, and the clinical data pointing to systemic inflammation as a primary driver of depressive symptoms. Plus, Kati breaks down the absolute differences between clinical depression, situational sadness, grief, and passive vs. active suicidal thoughts. What We Cover: The DSM-5 Checklist: The 9 diagnostic criteria for Major Depressive Disorder. The Serotonin Myth: Why modern psychiatric research is moving away from looking at single chemical levels. The Inflammation Connection: Active clinical trials utilizing anti-inflammatory pathways to treat mental health. Your Audio Action Plan: How to implement behavioral activation, circadian light exposure protocols, and cognitive tools to stop internal negative loops. Special Thanks to Our Sponsor: Go to hellorebound.com/AskKatiAnything to check your insurance or get matched with a virtual trauma specialist today. Real, evidence-based trauma treatment is within reach. If you are in immediate danger or experiencing a mental health crisis, please call or text 988 (US) or contact the Crisis Text Line by texting HOME to 741741. In the UK, you can reach the Samaritans at 116 123. You do not have to fight this alone. Learn more about your ad choices. Visit megaphone.fm/adchoices

Why do so many women enter perimenopause feeling like the rug has been pulled out from under them? In this powerful conversation, Dr. Mariza sits down with integrative medicine physician and menopause expert Dr. Melinda Ring to explore why perimenopause often feels so destabilizing and why so many women feel blindsided by symptoms they were never warned about. Together, they unpack the profound neuroendocrine changes happening during the perimenopause transition and why symptoms like sleep disruption, anxiety, brain fog, overwhelm, stress sensitivity, and feeling "not like yourself" often become some of the earliest signs that something is shifting. Dr. Ring explains the critical connection between hormones, the stress response system, sleep quality, nervous system regulation, and long-term health outcomes. They also discuss why traditional medical approaches have historically fallen short for women, the growing role of hormone replacement therapy, and why individualized care matters more than ever. The conversation dives deep into HPA axis dysfunction, trauma, chronic stress, self-compassion, resilience, and the importance of helping women feel safe in their bodies during a time of tremendous change. If you've ever wondered whether what you're experiencing is normal—or if you've found yourself saying, "I don't feel like myself anymore"—this episode offers both validation and practical guidance. Dr. Melinda Ring Dr. Melinda Ring is a board-certified physician, integrative medicine expert, educator, and internationally recognized leader in women's health and menopause care. She serves as Director of the Osher Center for Integrative Health and is passionate about helping women navigate perimenopause and menopause through evidence-based, whole-person care that addresses hormones, lifestyle, stress, sleep, and long-term health optimization. IN THIS EPISODE Why perimenopause often feels so overwhelming and unexpected The connection between sleep disruption, hormones, and brain health Why many women feel like they "don't feel like themselves" anymore The role of HPA axis dysfunction and chronic stress during midlife How trauma and long-term stress influence the menopause transition The evolving conversation around hormone replacement therapy Why individualized hormone care matters more than one-size-fits-all protocols How women can build resilience, safety, and self-compassion during perimenopause QUOTES“Sleep is the force multiplier.” “You can't heal in survival mode.” “The brain is reorganizing, not just the ovaries.” RESOURCES MENTIONED Use code ENERGIZED and get 10% off on your Troscription Order http://troscriptions.com/ENERGIZED Sign Up Now for the "Advanced Integrative Menopause Care for Clinicians" Course Training with Dr. Melinda Dr. Melinda Website https://www.drmelindaring.com/signup Dr. Melinda Instagram Dr. Melinda Facebook Dr. Melinda Tiktok Dr. Melinda Youtube RELATED EPISODES  756: What Low-Grade Inflammation Is Really Doing to Your Hormones, Brain & Metabolism with Dr. Mariza 755: What If Your Body Isn't Broken, Just Undernourished? The Missing Link Between Nutrients, Hormones & Energy with Ryan Woodburry 754: How to Find Joy When Life Doesn't Go According to Plan with Amberly Lago 717: “I Don't Feel Like Myself Anymore”: The Mental & Emotional Reality of Perimenopause

Most women have been told their cycle is something to manage, track for fertility, or push through. What almost no one is saying is that your cycle is a second biological clock running inside your body at all times. The circadian rhythm is roughly 24 hours and is governed by light. The infradian rhythm is roughly 28 days and is governed by the menstrual cycle. Men have one main rhythm. Women have two. This is not a flaw in our design. It is added intelligence. In this solo episode, Michelle walks you through what is actually happening underneath the surface of each phase. Your brain structure shifts across the cycle. Your immune system, metabolism, insulin sensitivity, microbiome, and nervous system are all moving with you. You will learn why the same stressor can feel completely different from one week to the next, why luteal phase cravings are real signals and not willpower failures, and how to begin matching your work, food, and rest to the phase you are actually in. Whether you are trying to conceive or simply want to stop fighting your own body, this episode offers a more accurate map of how you are designed to function.   Key Takeaways: Women have two main biological rhythms. The circadian rhythm is roughly 24 hours. The infradian rhythm is roughly 28 days and is governed by the menstrual cycle. Most lifestyle and research advice is built around the male 24-hour clock, which is part of why so many women feel exhausted. Your brain structure literally changes across the cycle. The hippocampus shifts in volume, connectivity between regions changes, and verbal fluency, spatial reasoning, and pain perception all move with the phases. Feeling like a different person at different times of the month is neurobiology, not emotional volatility. Your immune system is rhythmic. It is more active in the first half of the cycle and shifts after ovulation, when progesterone becomes mildly immunosuppressive to prepare the uterus for a possible embryo. This is why colds, autoimmune flares, and allergies can shift across the month. Basal metabolic rate rises slightly in the luteal phase, and insulin sensitivity changes. The same meal can land differently depending on where you are in your cycle. Luteal phase cravings are often a real signal of higher energy needs. The gut and vaginal microbiomes also shift cyclically with hormones. You are not a static system. Everything inside your body moves with you. Heart rate variability tends to be higher in the follicular phase and lower in the luteal phase. The same stressor can land very differently depending on when in the month it arrives. Your nervous system is operating from a different baseline. From a TCM perspective, the liver works harder in the luteal phase to prepare for menstruation, which can show up as more irritability, less energy, and stagnation when qi is not flowing freely. Working with the cycle is not just a fertility tool. It is a way of living that supports energy, focus, mood, and recovery across the entire month. Practical starting points: track more than your period (energy, sleep, mood, focus, hunger, stress response), match the work to the phase when possible, and eat in a way that responds to what your body is actually doing in each phase.   Host Bio: Michelle Oravitz, L.Ac., FABORM, is a board-certified fertility acupuncturist, Ayurvedic practitioner, and author of The Way of Fertility. She is the host of The Wholesome Fertility Podcast, where she explores the intersection of Traditional Chinese Medicine, modern fertility science, nervous system health, and the deeper, often overlooked terrain of mind-body fertility. Through her clinical practice and online programs, Michelle works with women trying to conceive and with practitioners who want to bring a more holistic, integrated approach into their work.   Research and Resources Cited: Brain structure and function changes across the menstrual cycle (hippocampal volume) Cyclical changes in hippocampal volume across the menstrual cycle Menstrual cycle effects on cognition: verbal fluency and spatial reasoning Pain perception and threat sensitivity across the menstrual cycle Progesterone and immune modulation in the luteal phase Basal metabolic rate variation across the menstrual cycle Insulin sensitivity and the menstrual cycle Gut microbiome variation across the menstrual cycle Vaginal microbiome shifts across the menstrual cycle Heart rate variability across the menstrual cycle Cortisol and HPA axis response across the menstrual cycle   Disclaimer: The information shared on this podcast is for educational and informational purposes only and is not intended as medical advice. Please consult with your healthcare provider before making any changes to your health or fertility care.  Ready to discover what your body needs most on your fertility journey? Take the personalized quiz inside The Wholesome Fertility Journey and get tailored resources to meet you exactly where you are: https://www.michelleoravitz.com/the-wholesome-fertility-journey For more about my work and offerings, visit: www.michelleoravitz.com Curious about ancient wisdom for fertility? Grab my book The Way of Fertility: https://www.michelleoravitz.com/thewayoffertility Join the Wholesome Fertility Facebook Group for free resources & community support: https://www.facebook.com/groups/2149554308396504/ Connect with me on social: Instagram: @thewholesomelotusfertility Facebook: The Wholesome Lotus

Every leader feels it. The 3am spiral. The Sunday night dread. The tight chest before a hard conversation. The mind that never fully stops — replaying, rehearsing, anticipating, calculating — even when you have physically left the building. That anxiety is not a sign that something is wrong with you. In Episode 2 of The Weight of the Chair series, certified Functional Diagnostic Nutrition Practitioner and Christian Life Coach Tanya Engesether takes an honest, clinical, and deeply personal look at the specific anxiety that accompanies leadership — what makes it different from ordinary anxiety, what is actually happening in the nervous system when it shows up, and why it makes complete physiological and emotional sense. Drawing from neuroscience, functional health, and a faith-rooted perspective, Tanya walks through the role of the amygdala, the HPA axis, and the prefrontal cortex in the leadership anxiety experience — and names the specific ways chronic stress in a leadership role leaves its mark on the body. She also addresses the people-pleasing thread that amplifies leadership anxiety for many women, and offers Philippians 4:6-7 not as a platitude but as a genuine neurological and spiritual practice. And then she gets personal — sharing her own toolkit for the moments when the anxiety gets loud. If you have ever wondered why the anxiety of leadership feels different from anything you prepared for — this episode will give you language, clinical understanding, and practical tools for working with it rather than pushing through it. In This Episode You'll Learn: What makes leadership anxiety distinct from ordinary anxiety The four specific dimensions of leadership anxiety most leaders never have language for What the amygdala, the HPA axis, and the prefrontal cortex are doing during high-stakes leadership moments Why your body cannot distinguish between physical threat and psychological threat — and what that means for leaders Why the prefrontal cortex gets suppressed exactly when you need it most — and what to do about it The somatic signature of anxiety — why it lives in the body and cannot be thought away How people-pleasing patterns amplify leadership anxiety — and what that means Philippians 4:6-7 as a clinical and spiritual practice — not a platitude The physiological sigh — the fastest known way to activate the parasympathetic nervous system Tanya's personal toolkit for leadership anxiety — specific, practical, honest When anxiety is information rather than just noise — and how to tell the difference Scripture Referenced Philippians 4:6-7 — "Do not be anxious about anything, but in every situation, by prayer and petition, with thanksgiving, present your requests to God." 1 Peter 5:7 — "Cast all your anxiety on him because he cares for you." Key Takeaway The anxiety that comes with the seat is not evidence of inadequacy. It is the natural, predictable, neurologically inevitable response to carrying genuine responsibility for outcomes and people that matter. Understanding what your nervous system is doing — and having real tools to work with it — changes not just how you feel in the role, but who you are in the role. I hope this episode blesses you! Xoxo, Tanya Episode Resources: Episode Catalog   My trusted Supplement Dispensary: Aligned Vitality Fullscript Dispensary My trusted Telehealth Peptide Provider:  EllieMD_Tanya Engesether *I do get a small commission when you use one of the above affiliate links. 3 Ways To Connect With Me: 1️⃣COACHING: Are you READY to Lead Well, Live Well and BE Well? Find out more about functional health or Christian Life coaching. It's the accountability and guidance you need to reclaim your health and happiness! ➡︎ https://alignedvitalityhealth.com/coaching   2️⃣ FACEBOOK: Become part of our Supportive Facebook Group. Connect, share, and learn with others navigating life and leadership ➡︎ https://alignedvitalityhealth.com/community   3️⃣ CONTACT: Leave me a question or comment ➡︎ https://alignedvitalityhealth.com/contact   "Yes! Finally, a podcast helping others become the thriving leaders they're meant to be outside of hustle-culture! This is an amazing resource! Thank you so much for sharing and helping us become Spirit-driven, peaceful leaders!"    If you can relate, please consider rating and reviewing my show! It helps me reach more people – just like you – to help them change their future. Don't forget to follow the show so you don't miss any episodes! And, if you're feeling really generous, I'd be SO honored if you would share this podcast with someone.   Click here to view our privacy policy.   Reminder:  The information you hear on this show is not meant to diagnose, treat, cure or prevent disease.  It is for educational purposes only. Always consult with your own health practitioner before you make any changes to your health.

Managing combat stress requires more than standard medical care. Learn how to address HPA axis disruption and take control of your health data. The standard medical system often fails to address the unique physiological impact of combat stress. This video explains why your HPA axis may be disrupted and how chronic inflammation often goes overlooked in routine checkups. If you feel like your current treatment plan is missing the root cause of your symptoms, this approach offers a different path. We outline a stack approach that integrates independent clinicians and self-paid labs alongside your existing care. By securing a fuller inflammation panel, you gain a clearer picture of your body's actual state. This method prioritizes personal ownership of your medical decisions, ensuring you have the data needed to advocate for your own recovery rather than relying solely on a system not designed for these specific needs. Subscribe for weekly health strategy breakdowns, and comment below if you have ever had to order your own lab work to get answers. Find everything at https://hardtokill.org/

You're not depressed. You're not in crisis. You're functioning, showing up, holding it all together. But something is still off, and you can't quite name it.This episode is for that person.Brandi and Dr. Desiree Caruso, ND sit down to break down the real biology behind low-grade mood dysregulation — the kind that doesn't show up in standard bloodwork but is absolutely happening in your body. We're talking about two specific functional mushrooms, lion's mane and reishi, and going straight into the mechanisms: the actual compounds, the actual pathways, and the actual research that explains why these mushrooms have a genuine relationship with how you feel.This is not a vibe episode. This is the science.We've been asked over and over again whether functional mushrooms can do something for mood, and if so, how. Today we answer that question properly. If you've ever walked out of a doctor's appointment feeling dismissed — told everything looks normal, maybe it's stress, maybe it's your age — this episode is what comes next.What you'll learn:Why mood is a physiological state, not just a feeling, and what that means for how you address itThe specific terpenoid compounds in lion's mane (hericenones) that can cross the blood-brain barrier and what they do once they get thereWhy BDNF is the mechanism most antidepressants are thought to work through, and how lion's mane stimulates it directlyHow 90% of your serotonin is produced in your gut, and exactly how lion's mane supports that pathwayThe three-directional approach lion's mane takes: blood-brain barrier, neuroinflammation, and gut-brain axis simultaneouslyWhat the HPA axis is, why chronic stress dysregulates it, and how reishi's ganoderic acids help restore the natural cortisol rhythmReishi's relationship with GABA, the brain's calming neurotransmitter, and why that explains the felt sense of settling downThe 2026 randomized controlled trial showing measurable reductions in anxiety, cortisol, and inflammation at 12 weeksHow disrupted sleep literally changes how your brain processes emotional information, and the two specific mechanisms reishi addresses to help with thatHow to self-diagnose which mushroom fits your experience right now, and what to track over four weeks to know whether it's workingResources Mentioned:Dr. Andrew Huberman episode on adenosine and coffee: https://www.hubermanlab.com/episode/using-caffeine-to-optimize-mental-and-physical-performanceVigna, L. et al. (2019). "Hericium erinaceus Improves Mood and Sleep Disorders in the Elderly." Journal of Medicinal Food, 22(5).Contato, A.G. & Conte-Junior, C.A. (2025). "Lion's Mane Mushroom (Hericium erinaceus): A Neuroprotective Fungus with Antioxidant, Anti-Inflammatory, and Antimicrobial Potential — A Narrative Review." Nutrients, 17(8), 1307.Frontiers in Nutrition (2025). "Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review." Frontiers in Nutrition, 12, 1641246.Ratto, D. et al. (2023). "Hericium erinaceus: Acute and Chronic Effects on Cognitive Function, Stress, and Mood in Young Adults." Nutrients, 15(22), 4842.Cui, X.Y. et al. (2012). "Extract of Ganoderma lucidum prolongs sleep time in rats." Journal of Ethnopharmacology / Pharmacology Biochemistry and Behavior. PMID: 22297086.Yong, V.K.J. et al. (2026). "A blend of medicinal mushrooms including Reishi reduces anxiety, cortisol and CRP in a 12-week randomized controlled trial." Brain and Behavior.Your Next Steps:Follow us on Instagram: https://www.instagram.com/eversiowellness/Shop Eversio Wellness and save 15% with code PODCAST15: https://www.eversiowellness.com/discount/PODCAST15?redirect=%2Fcollections%2Fall-productsTake our wellness quiz to find the right mushroom for you: https://www.eversiowellness.com/pages/take-our-quiz

Wir alle haben Vorstellungen davon, wie unser Leben verlaufen soll und geraten in Stress, wenn die Realität davon abweicht. Doch was passiert, wenn sich eine Situation nicht verändern lässt, egal wie sehr wir kämpfen, kontrollieren oder hoffen?In dieser Folge sprechen wir über Akzeptanz – nicht als Aufgeben, sondern als mutigen Schritt aus dem Widerstand. Du erfährst, warum oft nicht die Situation selbst das größte Leid verursacht, sondern der Kampf gegen das, was bereits ist, und wie Akzeptanz deinem Nervensystem helfen kann, wieder Ruhe, Klarheit und Handlungsspielraum zu finden.---

Have you spent your entire life solving problems by thinking harder, working harder, and pushing through only to discover that fertility is the one challenge that refuses to respond?For many high-achieving women, the same drive, discipline, and ambition that fuel success in business and life can create a chronic stress response that impacts fertility behind the scenes.In this episode, you'll learn...-Why chronic stress can shift your body's priorities away from reproduction and toward survival.-The biological connection between cortisol, progesterone, the HPA axis, and fertility hormones.-A simple 5–10 minute daily fertility prescription designed to help regulate your nervous system and create a more fertility-supportive environment.Listen now to learn how one small daily practice can help calm your stress response, support your hormones, and create the biological conditions your body needs to move closer to pregnancy.

In this episode, I'm tackling one of the most misunderstood topics in women's health: adrenal fatigue. While the term "adrenal fatigue" isn't technically accurate, the symptoms women experience are very real. What's actually happening is something called HPA axis dysfunction, a breakdown in the communication between the brain and adrenal glands that impacts energy, hormones, metabolism, sleep, and overall health. I explain what the HPA axis is, why chronic stress changes how your body responds to cortisol, and how major life events can push your system into dysfunction even when you're doing all the "right" things. We also dive into the three major stressors that affect the body: traumas, toxins, and thoughts. If you've been feeling exhausted, overwhelmed, stuck, or like your body just isn't responding the way it used to, this episode will help you understand what's really happening beneath the surface. If you're ready to stop guessing and get personalized guidance, schedule a free Strategy Call with my team. We'll review your symptoms, discuss your health goals, and help you identify the best next steps for your body. Schedule your Strategy Call here: https://calendly.com/dr-beth-westie/program-discovery-call Download your FREE Hormone Cascade Map here: https://dr-beth-westie.mykajabi.com/hormone-cascade-map

Nobody told you it would feel like this. You prepared for the hard decisions, the difficult conversations, the long hours. You read the books, completed the training, built the skills. You knew leadership would be challenging. What nobody told you was how lonely it would be. In the first episode of The Weight of the Chair series, Tanya Engesether opens a conversation that most leadership podcasts never have — the specific, confusing, hard-to-name loneliness that lives inside leadership. Not the loneliness of having no one around. The loneliness of being surrounded — and still somehow separate. With her signature blend of personal vulnerability, functional health insight, and faith-rooted perspective, Tanya names what leadership loneliness actually is, why it catches high-achieving women so completely off guard, what it does to the body physiologically, and what she has personally learned to do when it hits. Including a visit to one of the most underused stories in leadership content — the prophet Elijah under the juniper tree — and what God's response to his complete depletion reveals about how we are meant to be met in our hardest moments. If you have ever sat in a full room and felt completely alone — this episode was made for you. In This Episode You'll Learn: What makes leadership loneliness different from ordinary loneliness The four specific characteristics of leadership isolation that most leaders never have language for Why the authority of leadership changes relationships in ways that create genuine distance Why leadership loneliness catches high-capacity women especially off guard The story of Elijah in 1 Kings 19 — and what God's response to his depletion reveals The clinical picture — what chronic loneliness does to the HPA axis, cortisol, inflammation, immune function, and sleep Why tending to leadership loneliness is not weakness — it is healthcare Tanya's personal strategies for navigating the loneliness of leadership — specific, practical, and honest Why peer relationships are the most clinically and experientially important investment a leader can make What specific prayer looks like versus general prayer — and why it matters Scripture Referenced 1 Kings 19:4–18 — Elijah under the juniper tree 1 Kings 19:7 — "Get up and eat, for the journey is too much for you." 1 Kings 19:18 — "I reserve seven thousand in Israel." Key Takeaway The loneliness of leadership is not evidence that you are doing it wrong. It is evidence that you are carrying something real — something that deserves to be tended rather than pushed through. The God who met a depleted, lonely prophet under a tree is the same God who is with you in the weight of the chair. This Is Episode 1 of The Weight of the Chair Series   I hope this episode blesses you! Xoxo, Tanya Episode Resources: Episode Catalog   My trusted Supplement Dispensary: Aligned Vitality Fullscript Dispensary My trusted Telehealth Peptide Provider:  EllieMD_Tanya Engesether *I do get a small commission when you use one of the above affiliate links. 3 Ways To Connect With Me: 1️⃣COACHING: Are you READY to Lead Well, Live Well and BE Well? Book a FREE discovery call with me to find out more about functional health or Christian life coaching. It's the accountability and guidance you need to reclaim your health and happiness! ➡︎ https://alignedvitalityhealth.com/coaching   2️⃣ FACEBOOK: Become part of our Supportive Facebook Group. Connect, share, and learn with others navigating life and leadership ➡︎ https://alignedvitalityhealth.com/community   3️⃣ CONTACT: Leave me a question or comment ➡︎ https://alignedvitalityhealth.com/contact   "Yes! Finally, a podcast helping others become the thriving leaders they're meant to be outside of hustle-culture! This is an amazing resource! Thank you so much for sharing and helping us become Spirit-driven, peaceful leaders!"    If you can relate, please consider rating and reviewing my show! It helps me reach more people – just like you – to help them change their future. Don't forget to follow the show so you don't miss any episodes! And, if you're feeling really generous, I'd be SO honored if you would share this podcast with someone.   Click here to view our privacy policy.   Reminder:  The information you hear on this show is not meant to diagnose, treat, cure or prevent disease.  It is for educational purposes only. Always consult with your own health practitioner before you make any changes to your health.

Coffee First Thing, Fasted Workouts, and Why Your Morning Routine Is Wrecking Your Hormones in Midlife Morning fatigue isn't just about bad sleep — the first hour of your day shapes your hormone balance, metabolism, brain fog, and energy. Have you ever done everything "right" — fasted workout, coffee on an empty stomach, fasting until noon — and still felt more exhausted and anxious than ever? In this solo episode, I break down why those wellness habits are cortisol-wrecking chaos for a midlife woman. They were built for a twenty-five-year-old man's body, not yours. I'll walk you through six science-backed things to do before 9 AM that actually match your physiology, plus a twenty-minute version for busy mornings. Key Points The one simple swap that changes how women feel more than almost anything I recommend — and why order matters more than the habit. Why that "I can't function without coffee" feeling isn't an addiction — it's a hormonal clue most women miss. The reason your thyroid labs keep coming back "normal" while you still have every symptom of an underactive thyroid. How one client lost weight and got her energy back with six small morning swaps. We connect the dots between cortisol, the HPA axis, blood sugar, thyroid function, and metabolism — so you can finally understand why the "healthy" things you're doing might be working against you. Stop wasting time (and money) on products that don't work. My Trusted Brands Guide is the exact list I share with my private clients — the skincare, supplements, food, and wellness tools that have been tested and proven to deliver results. No fluff. No guesswork. Just the brands you can finally feel good about using. ✨ Plus, I scored exclusive discounts from some of these companies just for my community.

For most people, donor eggs is at the bottom of the list. It is not where you wanted to land. And if your clinic is recommending it, something in you is saying there has to be more to look at first. Here is what we see every week. The donor egg recommendation rarely arrives after a complete workup. It arrives after looking at the AMH, the FSH, the follicle count, maybe a basic semen analysis, and maybe being told your TSH is normal. Those numbers are real. The diagnosis is real. What gets called complete is the question. This episode is the 11 specific things we most often find skipped before the recommendation gets made. Pull it up. Take notes. Bring it to your next appointment. The 11 patterns: 1. Thyroid, the full panel, not just TSH 2. The gut, including H. pylori 3. Hidden food sensitivities 4. Medications you are already on that affect fertility 5. The vaginal microbiome 6. The seminal microbiome 7. The male partner's full bloodwork 8. Sperm DNA fragmentation 9. Vaginal and seminal cross-contamination between partners 10. The nervous system and HPA axis 11. Liver function and hormone clearance These are the tests that sit outside the standard fertility workup. A 2024 study in Archives of Gynecology and Obstetrics found that ovarian reserve markers like AMH do not significantly predict natural conception in women with regular cycles. The donor egg recommendation comes from one snapshot, not the full investigation. If this is the first episode you have landed on in this series, go back and listen to "Told Donor Eggs Are Your Only Option? Ask This First," then "How Long Should I Try With My Own Eggs Before Donor Eggs?" then "The Gut Findings Your Clinic Did Not Look For," and "Multiple Failed IVF And Told Donor Eggs?" This episode brings all of it together. WHAT YOUR CLINIC MISSED The companion guide walks through all 11 of these patterns in more detail, so you can take it to your next appointment and ask the questions. Email hello@fabfertile.ca, subject line MISSED, and we will send you the guide. FUNCTIONAL FERTILITY SECOND OPINION A free 45-minute call where I review your labs, your history, and your partner's results with you. You leave knowing what your biology has been telling you and what your next decision could be. Email hello@fabfertile.ca, subject line FERTILE, or book here. ABOUT THE HOST I'm Sarah Clark, founder of Fab Fertile and host of Get Pregnant Naturally, a podcast with over one million downloads. My functional fertility team works with couples navigating low AMH and failed IVF, reviewing functional lab results, gut microbiome, food sensitivity, vaginal microbiome, nutrigenomics, HTMA, DUTCH, toxin testing, and bloodwork alongside nervous system work, to help identify patterns that may not have been considered. We work alongside your medical team, not instead of them. Sarah Clark, founder of Fab Fertile, host of Get Pregnant Naturally (1M+ downloads), and author of Fabulously Fertile. If this episode helped, leave a review on Apple Podcasts. It is how other women find this work. TIMESTAMPS 00:00 The Donor Egg Recommendation and What Gets Called Complete 01:00 Who's Reviewing Your Case at Fab Fertile 02:00 Thyroid: The Full Panel, Not Just TSH 03:00 The Gut and H. pylori 04:00 Hidden Food Sensitivities 05:00 Medications That Affect Fertility 06:30 The Vaginal Microbiome 08:00 The Seminal Microbiome 08:30 The Male Partner's Full Bloodwork 09:00 Sperm DNA Fragmentation 09:30 Cross-Contamination Between Partners 11:00 The Nervous System and HPA Axis 11:30 Liver Function and Hormone Clearance 13:00 The Functional Fertility Second Opinion

If you have been doing everything right and still getting migraines, this episode is for you. This week we are kicking off a three-part series for Migraine Awareness Month, and we are going somewhere most people never go. Not your triggers. Not your medications. Not another list of things to avoid. We are talking about your brain. Specifically, a small almond-shaped structure called the amygdala, and why it may be running your entire migraine cycle without anyone ever explaining that to you. In this episode you will learn  what the amygdala actually is and what it was designed to do  how it connects directly to the trigeminal nerve and your HPA axis why chronic inflammation and hormonal shifts put it into a state of low-grade constant activation what central sensitization actually means and why it explains so much of what you have been experiencing why the smoke detector analogy changes the way you think about everything you have tried so far. This is the episode that reframes the whole conversation. Because once you understand that your nervous system has recalibrated itself toward threat, the question stops being what did I do wrong and starts being what does my nervous system need to finally stand down. Ready to find out where your own Inflammation Overload Loop is breaking down? Take the free Migraine Sensitivity Scorecard. The link is below. Resources: Migraine Sensitivity Scorecard: https://pages.debbiewaidlcoach.com/quiz FREE DOWNLOAD: Toxic Migraine Triggers Guide Get the complete guide showing you the hidden inflammatory triggers fueling your migraines, including toxins in your medication, environment, and everyday life. https://dwvirtualguide.com/free-guide Book a Free Migraine Breakthrough® Assessment: Let's assess your unique migraine situation and uncover what's been keeping you stuck. https://pages.debbiewaidlcoach.com/breakthroughcall-social-7269 Connect with Debbie: Facebook: https://www.facebook.com/DebbieWaidlCoach/ Instagram: https://www.instagram.com/debbiewaidl.coach/ Women's Migraine Freedom™ Facebook Group: https://www.facebook.com/groups/womensmigrainefreedom Website: https://pages.debbiewaidlcoach.com/ Email: freedom@debbiewaidl.com Disclaimer: The Migraine Freedom™ Your Way Podcast and information provided by Debbie Waidl and guests is presented solely to provide helpful information, education, and entertainment on the subjects discussed. The use of information or resources mentioned on or linked from this podcast is at the user's own risk and discretion. This podcast is not intended to diagnose or treat any medical condition. For diagnosis or treatment of any medical problem, consult your own physician. Debbie Waidl and In The Balance Health Coaching, LLC are not responsible for any medical conditions or liable for any damages or negative consequences from any treatment, action, application, or preparation to any person reading or following the information presented on this podcast. References are provided for informational purposes only and do not constitute an endorsement of any websites or other sources.  

If you are waking up between 2:00 and 4:00 AM, lying there wide awake with your heart beating a little too fast and your mind solving every problem in your life, this episode is for you. Because this is not just about bad sleep. It is about what happens when the hormonal, adrenal, and nervous system shifts of midlife collide with the stress load most women are already carrying. And for a lot of women, this is the moment they stop feeling like themselves. In this episode, I do a deep dive into what is actually happening beneath the surface when women in perimenopause and menopause start feeling wired, tired, fragile, overwhelmed, anxious, and unable to recover the way they used to. We talk about the HPA axis, cortisol rhythm, DHEA, blood sugar, stress intolerance, adrenal strain, and why the advice women are getting online is often way too surface level to actually help. I also share what this has looked like in my own body, why midlife can feel like the season where your body stops tolerating the way you have been living, and why that is not a personal failure. It is physiology. This episode lays the foundation for understanding the deeper systems driving midlife sleep disruption and stress dysregulation, so you can stop blaming yourself and start getting clearer on what your body may actually need. In this episode, we cover: Why 2:00 to 4:00 AM wakeups are so common in perimenopause and menopause The difference between being tired and being hormonally and neurologically dysregulated What the HPA axis is and why it matters for stress and sleep How estrogen and progesterone affect stress resilience and recovery Why cortisol is not the enemy, but timing matters How cortisol dysregulation can affect sleep, anxiety, belly fat, and energy Why DHEA is one of the most overlooked hormones in midlife The connection between blood sugar drops and middle-of-the-night wakeups Why the old coping strategies stop working in midlife Why testing cortisol rhythm and DHEA can be so helpful Who this episode is for This episode is for women in perimenopause and menopause who are struggling with broken sleep, 3 AM wakeups, stress intolerance, fatigue, anxiety, feeling wired at night, crashing in the morning, or just feeling like they cannot handle life the way they used to. It is especially for women who want to understand the deeper physiology behind what is happening instead of being told to just relax, meditate, or take one supplement and hope for the best.     Sponsors Try Vitali Exosomes Skin Care vitaliskincare.com use coupon KM20 to get 20% off your order! Get 30% off BATCH Gummies. Go to hellobatch.com/HORMONE and use code HORMONE at checkout. Timeline is offering up to 39% off your first order of Mitopure. Gummies. Go to timeline.com/HORMONE use coupon HORMONE     Are you in perimenopause or postmenopause and struggling with symptoms—but not getting the support you deserve? At Midlife Solutions, we specialize in hormone optimization for women in midlife. Our all-female clinical team offers telehealth care across all 50 U.S. states, with the ability to prescribe bioidentical estrogen, progesterone, testosterone, and thyroid medication.   Book your FREE Hormone Discovery Call Find out what's really driving your symptoms and what your next best steps are.   Visit the website: https://karenmartel.com   Shop the Midlife Solutions Store Over-the-counter bioidentical hormone creams and oils — no prescription needed. Including: • Progesterone • Estrogen Face Cream • Vaginal Moisturizer and more!   Take the Hormone Quiz Discover hidden hormone imbalances that could be driving your symptoms. Get personalized results (and yes, they may surprise you).   Women's Peptide Weight Loss Program Clinically guided, hormone-aware weight loss for midlife women.   Midlife RESET HRT Program A complete, supportive approach to hormone replacement therapy in midlife.   Your host: Karen Martel Certified Hormone Specialist, Transformational Nutrition Coach, & Weight Loss Expert   Karen's Facebook Karen's Instagram

In this episode Nancy McLean answers listener emails about geldings that chew lead ropes and reins, she explains how cortisol and the HPA axis relate to stress-driven behaviors, and describes how consistent training, handler calmness, routines, turnout, and nutrition can help horses down-regulate stress. The episode also summarizes research on cortisol sampling methods (plasma, saliva, hair) for short- and long-term stress assessment, and closes with a brief update on a new world screwworm outbreak, what has been done historically to eradicate it, and practical steps owners should take if they suspect infestation. Research: https://www.mdpi.com/2077-0472/13/12/2219 https://assets.cureus.com/uploads/review_article/pdf/413141/20251106-69309-xadaoe.pdf  

After 30 years in health, Dr. Mindy is calling time on the rules.This solo episode is one of the most personal things she's shared on this podcast. It covers two big ideas: the science and story behind why she stopped fasting for most of the past year and the five health habits she's deliberately walking away from in 2026.First, flex fasting. When cortisol is high from grief, trauma, illness, perimenopause, or chronic stress rigidly pushing through long fasting windows doesn't support the body. It depletes it. Dr. Mindy shares what happened when she lost a close friend and found herself in an acute stress state, what the research says about prolonged fasting and the HPA axis, and how she developed a new approach she's calling flex fasting: a more intuitive, body-led way to use fasting as a tool without turning it into a rule.Then the five things she's giving up: counting (macros, biometrics, followers, all of it), the gym, other people's urgency, productivity over health, and information overconsumption. Each one is a direct response to what the wellness industry has quietly done to us — turned health into a full-time job with a performance review.RESOURCES MENTIONED:Fast Like a Girl: https://www.drmindypelz.com/booksAge Like a Girl: https://www.drmindypelz.com/booksSubstack Article "I Stopped Fasting for a Year": https://substack.com/@drmindypelz/Carb Manager App carbmanager.com, available on iOS, Android, and webThe Movement Diet: Redefining Fitness at Every Age with Katy BowmanStudy: Prolonged Fasting, HPA Axis & Cortisol - https://pmc.ncbi.nlm.nih.gov/articles/PMC12736288/Study: Estrogen & Cortisol Regulation - https://academic.oup.com/jcem/article/102/12/4457/4587523Midlife Women Fasting Trial - https://www.nature.com/articles/s41467-025-65678-zStudy: Self-Selected Fasting Windows - https://www.nature.com/articles/s41591-024-03375-yBEAM Minerals, use code MINDY for 20% off: https://www.beamminerals.com/?oid=4&affid=648LMNT, get a free sample pack with your order: https://bit.ly/drinklmntpelzTo view full show notes, resources mentioned, transcripts, and more, visit

Interview with Dr. Mike Jones, MD of Impact Minerals Ltd.Our previous interview: https://www.cruxinvestor.com/posts/impact-minerals-asxipt-pitch-perfect-october-2025-8328Recording date: 8th June 2026Impact Minerals Limited (ASX:IPT) is undergoing a deliberate and material transformation. What began as a junior mining explorer is becoming, under the direction of Managing Director Dr. Mike Jones, a specialty chemicals and material science company with a credible path to producing high-purity alumina which is  a critical input for battery separators, artificial sapphire, advanced ceramics, and semiconductor components.The company's commercial strategy rests on two interconnected assets. The first is a 50% stake in Alluminous, which holds a patented solvent extraction process for producing HPA from widely available chemical feedstock. That intellectual property is now protected across the United States, Canada, and Southeast Asia, jurisdictions that management views as the primary commercialisation markets. The second is the Lake Hope clay project in Western Australia, where a Pre-Feasibility Study has been completed and work toward a Definitive Feasibility Study is underway.What has sharpened investor attention recently is a process engineering breakthrough at the Alluminous pilot plant. By modifying the orientation of impellers in the solvent extraction stage, the team achieved up to ten times the originally designed throughput. Dr. Jones has stated that this discovery could allow the company to reach production capacity comparable to its listed peers for under AU$10 million in capital — against the AU$200 million-plus spent by those peers to reach similar output levels. The scoping study for a 2,000-tonne-per-annum commercial plant is expected to provide independent cost validation shortly, making it one of the most significant near-term catalysts for the stock.The competitive context is instructive. Alpha HPA carries a market capitalisation of approximately AU$650–700 million. Advanced Energy Minerals trades at approximately AU$250–300 million. Both began as resource companies and have re-rated substantially as they have moved toward production. Impact Minerals currently sits at a significant discount to both, at a stage where the technology has been proven in batch mode, IP is protected, and initial customer engagement — including 3kg sapphire-grade samples dispatched to European buyers — is underway.The market entry strategy is measured. Rather than chasing premium 5N pricing immediately, management has chosen to enter the higher-volume 3N advanced ceramics segment first, building commercial credibility before moving up what Dr. Jones calls the "pyramid of purity." This approach mirrors the path taken by peers and reduces the risk of prolonged customer qualification timelines.The company's byproduct streams add further resilience to the investment case. Potash which is almost entirely imported into Western Australia and aluminium chlorohydrate have both attracted early buyer interest and are the subject of a separate scoping study. A joint venture on these streams would allow Impact to advance its HPA programme without proportional increases in capital expenditure.The principal risks are clear and should be held alongside the opportunity. Back-end engineering challenges remain unresolved, the technology has not yet been demonstrated at scale, and the company is pre-revenue. However, with patent protection secured, a breakthrough in production efficiency, a clear commercialisation roadmap, and peers trading at valuations ten to twenty times higher, the risk-reward profile at current prices warrants serious investor attention.View Impact Minerals' company profile: https://www.cruxinvestor.com/companies/impact-mineralsSign up for Crux Investor: https://cruxinvestor.com

Warum fühlen wir uns nach einem Streit in der Beziehung tagelang körperlich erschöpft, selbst wenn der Streit eigentlich schon vorbei ist? Die Antwort ist nicht, dass wir „zu empfindlich“ sind. Beziehungskonflikte machen uns nicht deshalb krank oder müde, weil sie stattfinden, sondern weil wir es oft nicht schaffen, uns danach gegenseitig wieder das Gefühl zu geben: „Du bist sicher, wir gehören zusammen.“ Welche Fragen beantwortet die Folge?„Warum bin ich nach einem Streit so extrem erschöpft, obwohl es nur eine Diskussion war?“„Warum kann ich mich nach einem Konflikt nicht alleine beruhigen?“„Warum reagiere ich so panisch und mein Partner so kühl?“„Ist meine Wahrnehmung falsch, wenn ich mich unsicher fühle?“„Was ist die Lösung? Muss ich lernen, nie wieder zu streiten?“„Warum hat das langfristige Folgen für meine Gesundheit?“---Wie erwähnt findest du hier, die beiden Workshops (8 Komponenten für sichere Bindung & Nervensystemreaktionen verstehen) hier:Kurs-Paket: Sichere Bindung lernen---

A dysregulated nervous system will stall body recomposition no matter how dialed the nutrition is or how consistent the training is. Inside today's episode, I dig into trauma as a physiological variable rather than a soft emotional topic, and why most coaching certifications skip this conversation entirely. I break down the autonomic nervous system and HPA axis interplay, the two nervous system presentations , and why the cortisol literature looked contradictory for years.Topics discussed: - Trauma as a Spectrum- Autonomic Nervous System Dysregulation- HPA Axis and Cortisol Output- Sympathetic Dominance Presentation- The Dissociative Subtype- Cortisol Patterns Over Time- Childhood vs Adult Trauma- Inverted Diurnal Rhythm- Lifestyle and Clinical Interventions- The Coach's Role and Scope---------- ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠My Live Program for Coaches: The Functional Nutrition and Metabolism Specialization ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.metabolismschool.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠---------- [Free] Metabolism School 101: The Video Series⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠http://www.metabolismschool.com/metabolism-101⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠----------Subscribe to My Youtube Channel: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://youtube.com/@sammillerscience?si=s1jcR6Im4GDHbw_1⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠----------⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Grab a Copy of My New Book - Metabolism Made Simple⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠---------- Stay Connected: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram: @sammillerscience⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Youtube: SamMillerScience⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Facebook: The Nutrition Coaching Collaborative Community⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠TikTok: @sammillerscience⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠----------“This Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast and the show notes or the reliance on the information provided is to be done at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment and is for educational purposes only. Always consult your physician before beginning any exercise program and users should not disregard, or delay in obtaining, medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions. By accessing this Podcast, the listener acknowledges that the entire contents and design of this Podcast, are the property of Oracle Athletic Science LLC, or used by Oracle Athletic Science LLC with permission, and are protected under U.S. and international copyright and trademark laws. Except as otherwise provided herein, users of this Podcast may save and use information contained in the Podcast only for personal or other non-commercial, educational purposes. No other use, including, without limitation, reproduction, retransmission or editing, of this Podcast may be made without the prior written permission of Oracle Athletic Science LLC, which may be requested by contacting the Oracle Athletic Science LLC by email at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠operations⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@sammillerscience.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. By accessing this Podcast, the listener acknowledges that Oracle Athletic Science LLC makes no warranty, guarantee, or representation as to the accuracy or sufficiency of the information featured in this Podcast."

This episode is about more than food. It's about understanding why we reach for certain foods, creating a realistic off-ramp from ultra-processed eating, and giving your body a chance to reset. If you've ever felt like you're doing everything right but still struggling with weight, energy, inflammation, or cravings, this episode is for you.   Citation: Hall, Kevin D., et al. “Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain: An Inpatient Randomized Controlled Trial of Ad Libitum Food Intake.” Cell Metabolism, vol. 30, no. 1, 2019, pp. 67–77.e3. https://doi.org/10.1016/j.cmet.2019.05.008 — This is the cornerstone. Same calories, sugar, fat, fiber, and macros on both diets; people ate ~500 kcal/day more on the ultra-processed one and gained weight. It's the strongest evidence that the processing, not just the nutrients, changes intake. Why fat + sugar together hijack reward more than either alone (the “hyperpalatable” mechanism) DiFeliceantonio, Alexandra G., et al. “Supra-Additive Effects of Combining Fat and Carbohydrate on Food Reward.” Cell Metabolism, vol. 28, no. 1, 2018, pp. 33–44.e3. https://doi.org/10.1016/j.cmet.2018.05.018 McDougle, Molly, et al. “Separate Gut-Brain Circuits for Fat and Sugar Reinforcement Combine to Promote Overeating.” Cell Metabolism, vol. 36, no. 2, 2024, pp. 393–407. https://doi.org/10.1016/j.cmet.2023.12.014 — Together these support your point that engineered fat-plus-sugar foods (the Doritos idea) light up reward pathways more than natural foods, because fat and sugar run on separate gut-brain circuits that combine. Why “glycemic velocity” matters — hidden refined starches like maltodextrin Hofman, Denise L., et al. “Nutrition, Health, and Regulatory Aspects of Digestible Maltodextrins.” Critical Reviews in Food Science and Nutrition, vol. 56, no. 12, 2016, pp. https://doi.org/10.1080/10408398.2014.940415 — Supports the egg-bite/maltodextrin point: maltodextrin is a refined starch with a glycemic index around 85–110, higher than table sugar, hiding on labels as “modified food starch.” Backs your “what the calories came from” framing. Why these foods genuinely relieve stress (your central, original thesis) Ulrich-Lai, Yvonne M., et al. “Pleasurable Behaviors Reduce Stress via Brain Reward Pathways.” Proceedings of the National Academy of Sciences, vol. 107, no. 47, 2010, pp. https://doi.org/10.1073/pnas.1007740107 Tomiyama, A. Janet, et al. “Comfort Food Is Comforting to Those Most Stressed: Evidence of the Chronic Stress Response Network in High Stress Women.” Psychoneuroendocrinology, vol. 36, no. 10, 2011, pp. 1513–1519. https://doi.org/10.1016/j.psyneuen.2011.04.005 — This is the science behind “the food was doing something right.” Palatable food measurably dampens the HPA (cortisol) stress axis through reward pathways — which is exactly why pulling it without replacing the stress tool fails. Why cravings are state-dependent and rise with stress (the “urge depends on the state of your blood / stress level” claim) Adam, Tanja C., and Elissa S. Epel. “Stress, Eating and the Reward System.” Physiology & Behavior, vol. 91, no. 4, 2007, pp. 449–458. https://doi.org/10.1016/j.physbeh.2007.04.011 Darcey, Valerie L., et al. “Brain Dopamine Responses to Ultra-Processed Milkshakes Are Highly Variable and Not Significantly Related to Adiposity in Humans.” Cell Metabolism, vol. 37, no. 3, 2025, pp. 616–628. https://doi.org/10.1016/j.cmet.2025.02.002  (edited)      WHAT TO EAT FOR THE NEXT SIX WEEKS — Protein. Plant. Potato. (P³) The formula for every meal: one protein + one plant + one starch (potato, or beans and rice). Add fat — olive oil, butter, avocado, cheese, nuts. Add flavor — salt, pepper, garlic, lemon, vinegar, salsa, hot sauce, herbs. This is not the meal you dreamed of. This is the meal that sets you free. BREAKFAST Eggs + sautéed vegetables + fruit on the side Plain Greek yogurt + berries + a handful of nuts Leftover chicken or beef + potato + vegetables (last night's dinner works) LUNCH Chicken + roasted potato + green salad with olive oil and lemon Tuna + white beans + cucumber + tomato, dressed with olive oil and vinegar Beef + potato + peppers + salsa DINNER Sheet-pan chicken + potatoes + green beans Instant Pot chicken + potato + a vegetable Burger patty (no bun) + potato + salad Batch chili (beef + beans + tomato) over rice Baked fish + sweet potato + roasted broccoli Pork + beans and rice + sautéed greens THE DURESS PLATE — for when the day collapses One protein + one plant + one starch, zero cooking. Examples: • Hard-boiled eggs + apple + handful of nuts • Tuna + canned beans + cucumber, with olive oil • Pre-cooked/frozen ground beef + frozen vegetables + microwave potato • String cheese + fruit + a few nuts (in a real pinch) SIMPLE RECIPES Sheet-Pan Chicken & Potatoes (serves 4) Toss chicken thighs and quartered baby potatoes in olive oil, salt, pepper, garlic. Roast at 425°F (220°C) ~35–40 min. Add green beans for the last 15 min. Batch Chili (serves 6) Brown 2 lb ground beef with chopped onion. Add 2 cans diced tomatoes, 2 cans beans (drained), garlic, cumin, chili powder, salt. Simmer 30+ min. Freezes well — make once, eat all week. Serve over rice. Instant Pot Chicken Chicken breasts + ½ cup broth + salt, garlic, paprika. Pressure cook 10 min, natural release 5. Shred. Pairs with any potato + vegetable. The 5-Minute Tuna Bean Bowl Can of tuna + can of white beans (rinsed) + diced cucumber and tomato. Dress with olive oil, lemon or vinegar, salt, pepper. Microwave Potato, Done Right Pierce a potato, microwave 5–7 min. Split, add butter or olive oil, salt, pepper. The reliable, universal starch. Remember: Don't aim for one perfect week repeated six times. Just follow the basic protocol the best you can for six weeks. When a craving hits, run the nine-minute interrupt from Episode 14.   Dr. Brendan McCarthy is the founder and Chief Medical Officer of Protea Medical Center in Arizona. With over two decades of experience, he's helped thousands of patients navigate hormonal imbalances using bioidentical HRT, nutrition, and root-cause medicine. He's also taught and mentored other physicians on integrative approaches to hormone therapy, weight loss, fertility, and more. If you're ready to take your health seriously, this podcast is a great place to start.

Emotional loneliness is one of the most common and least talked about experiences in complex trauma recovery. It's not about the number of people in your life. It's about whether your nervous system has learned to let them in. And for a lot of survivors, it hasn't. Not because something is permanently wrong with you, but because your nervous system learned some very specific things about connection a long time ago.In this episode, I break down some of the neuroscience and nervous system mechanics behind emotional loneliness in CPTSD, why it runs so much deeper than social isolation, and what actually helps.In this episode:Why emotional loneliness and social isolation are not the same thing, and why adding more people to your life won't fix the second oneThe push-pull cycle so many survivors live in, desperately wanting connection and pulling back the moment someone gets closeHow emotional neglect specifically creates a loneliness that's hard to name because the wound is in what didn't happen, not what didWhy hyperindependence is often a nervous system adaptation, not a personality traitThe role of the HPA axis and oxytocin in why connection can feel physically threatening even when you want itHow shame creates concealment, and how concealment sustains loneliness in a cycle that's hard to breakWhat dissociation and hypervigilance have to do with why connection doesn't land even when it's right in front of youWhy healing often makes loneliness feel worse before it gets better, and what that actually meansWhat capacity building looks like when the goal is learning to receive connection, not just find itResources that might support you:Episode 126: The Inner Critic with Emily PagoneEpisode 127: Attunement and Rupture in the Clinical Relationship with Katie FriesEpisode 128: Fawning as a Trauma ResponseThanks for listening to The Complex Trauma Podcast!Be sure to follow, share and give us a review on your favorite podcast platform.Follow on Instagram: @sarahherstichlcsw Follow on TikTok: @sarahherstichlcswLearn more about EMDR & trauma therapy in Pennsylvania with Reclaim TherapyThis podcast is for educational and informational purposes only. It is not intended as a substitute for professional medical, psychological, or nutritional advice, diagnosis, or treatment.Remember, I'm a therapist, but I'm not your therapist. Nothing in this podcast is meant to replace actual therapy or treatment. If you're in crisis or things feel really unsafe right now, please reach out to someone. You can call 988 for the Suicide and Crisis Lifeline, text them, or head to your nearest ER.The views expressed by the host and guests are their own and do not represent the opinions of any organizations or institutions. Reliance on any information provided by this podcast is solely at your own risk.

Send us Fan MailStress can quietly sabotage GLP‑1 therapies by turning up cortisol, spiking cravings, and flattening the satiety signals you're counting on. We unpack that hidden loop and share a practical playbook to lower stress, protect your appetite control, and make your plan more sustainable.We start by mapping how the HPA axis elevates cortisol and interferes with GLP‑1 secretion and action. From there, we explore the gut microbiome's role in incretin signaling and why fiber, prebiotics, and fermented foods can restore metabolic rhythm. You'll hear how small daily choices—hydration, meal timing, and protein plus fiber at each meal—smooth glucose swings and reduce the urgency that leads to overeating. We make mindfulness tangible with short breathing protocols, body scans, and progressive muscle relaxation you can layer into a busy day, plus mindful eating tactics that help fullness show up on time.Movement rounds out the plan. Aerobic sessions lower anxiety and improve insulin sensitivity, strength training supports lean mass and confidence, and yoga or tai chi blend relaxation with mobility. We explain how better sleep ties it all together, reinforcing appetite control and recovery so your medication works as intended. Throughout, we focus on simple, repeatable routines: anchor habits in the morning and evening, fiber first shopping, post meal walks, and community for accountability.If you're using semaglutide, tirzepatide, or another GLP‑1 and feel stuck, this conversation gives you the tools to reclaim momentum with a calm nervous system, a nourished gut, and a movement plan you enjoy. Subscribe, share this with someone on a similar journey, and leave a review telling us which habit you'll start this week. Support the showSponsor Affiliates Empowering Your Healthhttps://www.atecam.com/Get YOUR Own Joburg Protein Snacks Discount Code:  Damaris15 Or Damaris18Feeling need to Lose Weight & Become metabolically HealthyGET METABOLIC COURSE GLP 1 REseTThis course is designed for individuals looking to optimize their metabolic health through integrative and functional medicine approaches. Whether you're on a GLP-1 medication or seeking natural ways to enhance your metabolic function, this course provides actionable steps, expert insights, and a personalized roadmap sustainable wellness.Are you feeling stressed, tired, or Metabolism imbalanced? Take advantage of our free mindful steps to help improve your well-being.ENJOY ONE OF our Books Mindful Ways  Health Wealth & Life https://stan.store/MindfullyintegrativeJoin Yearly membership ALL IN ONE  FUNCTION HEALTHAsk Us for help with Medica...

Spoiler: you were never meant to do this alone. In the final episode of Joy Lab's Resilience series, Dr. Aimee Prasek and Dr. Henry Emmons explore the most powerful — and most underrated — ingredient in lasting resilience: deep, meaningful connection. They unpack the neuroscience of belonging, the illusion of separation that quietly wrecks our wellbeing, and two surprisingly accessible practices: shared-joy and moral elevation. These practices can open us to greater connection right now, no personality overhaul required. The takeaway from this episode is that deep connection isn't a bonus feature of a resilient life. It's the foundation. And the good news? You're already wired for it.   Try It Free

What if the root of your hormonal disruption, your chronic fatigue, your gut issues, and your anxiety isn't what your doctor has been looking for? What if it's people-pleasing? In this episode of Aligned Vitality, certified Functional Diagnostic Nutrition Practitioner and Christian Life Coach Tanya Engesether makes the clinical and spiritual case that people-pleasing is not just an emotional pattern — it is a chronic stress state with real, measurable consequences for the body. Drawing from functional health science, trauma-informed psychology, and a faith-rooted perspective, Tanya unpacks what people-pleasing actually is at a nervous system level, where it comes from, and what it is doing to your hormones, your gut, your thyroid, your immune system, and your brain. If you are a high-capacity woman in midlife who is exhausted, symptomatic, and starting to suspect that something deeper is at the root — this episode is for you. In This Episode You'll Learn: What people-pleasing actually is at a nervous system level — and why it's not a character flaw The fawn response — the fourth stress response most people have never heard of Where people-pleasing patterns typically originate — childhood, faith communities, identity, and worth The full metabolic cascade of chronic people-pleasing — from HPA axis dysregulation to hormones, gut, thyroid, inflammation, and neurotransmitters What the pregnenolone steal is — and why it matters for midlife hormone health Why midlife amplifies everything that chronic stress has been quietly building The difference between fear-driven appeasement and Spirit-led service What Galatians 1:10 has to say about people-pleasing and identity The physiological reality of living rooted in God's approval instead of human approval Where to begin — practically and spiritually — if this episode resonates Scripture Referenced Galatians 1:10 — "Am I now trying to win the approval of human beings, or of God?" Key Takeaway People-pleasing is not just emotionally costly — it is physiologically destructive. The fawn response keeps the body in a chronic stress state that disrupts hormones, degrades gut health, suppresses thyroid function, drives inflammation, and depletes the neurotransmitters responsible for mood and resilience. Healing begins when we address the root — not just the symptoms.   I hope this episode blesses you! Xoxo, Tanya   Book a FREE functional health discovery call HERE. Episode Resources: Episode Catalog   My trusted Supplement Dispensary: Aligned Vitality Fullscript Dispensary My trusted Telehealth Peptide Provider:  EllieMD_Tanya Engesether *I do get a small commission when you use one of the above affiliate links. 3 Ways To Connect With Me: 1️⃣COACHING: Are you READY to Lead Well, Live Well and BE Well? Book a FREE discovery call with me to find out more about functional health coaching. It's the accountability and guidance you need to reclaim your health and happiness! ➡︎ https://alignedvitalityhealth.com/coaching   2️⃣ FACEBOOK: Become part of our Supportive Facebook Group. Connect, share, and learn with others navigating life and leadership ➡︎ https://alignedvitalityhealth.com/community   3️⃣ CONTACT: Leave me a question or comment ➡︎ https://alignedvitalityhealth.com/contact   "Yes! Finally, a podcast helping others become the thriving leaders they're meant to be outside of hustle-culture! This is an amazing resource! Thank you so much for sharing and helping us become Spirit-driven, peaceful leaders!"    If you can relate, please consider rating and reviewing my show! It helps me reach more people – just like you – to help them change their future. Don't forget to follow the show so you don't miss any episodes! And, if you're feeling really generous, I'd be SO honored if you would share this podcast with someone.   Click here to view our privacy policy.   Reminder:  The information you hear on this show is not meant to diagnose, treat, cure or prevent disease.  It is for educational purposes only. Always consult with your own health practitioner before you make any changes to your health.

Dr. Corey Schuler, PhD(c), FNP, DC, CNS, and director of medical affairs at Allergy Research Group, details his paper “Energy Allocation Resilience and Endocrine Integration” in the International Journal of Molecular Sciences. He introduces the Energy Allocation System (EAS), which emphasizes how the body allocates energy—not just produces it—and links many symptoms to impaired bioenergetics and resilience. They discuss mitochondria as energy generators and cellular signaling hubs, the integrated stress response and endocrine coordination (HPA axis, thyroid, gonads), and mitohormesis/eustress (exercise, fasting, heat/cold, circadian “zeitgebers”). Schuler explains nuanced testing for fatigue (diurnal cortisol, CGM patterns, thyroid markers including T3/reverse T3) and a case of a perimenopausal woman where oral contraceptives and cortisol dysregulation affected glucose patterns. They cover mitochondrial support (removing obstacles like pollutants/antibiotics, triglycerides, carnitine, dietary fats, micronutrients) and pacing/sequencing lifestyle interventions.

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In Episode 44 of Pursuit of Balance, Corey breaks down how exercise directly and indirectly improves mental health — and why "the best path to the mind is through the body." This isn't your typical mental health awareness conversation. Instead of journaling, breathing, and bubble baths, Corey gets into the actual mechanisms behind why training works — and the indirect benefits most people don't realize they're signing up for when they commit to a real fitness routine. What we cover: -Why exercise is technically a stressor (and how that actually builds stress resilience) -BDNF and why post-workout is one of the best times to learn -How aerobic training recalibrates your HPA axis and stress threshold -Vagal tone, HRV, and what your nervous system is trying to tell you -The neurotransmitter cocktail behind the runner's high -The biggest mistake people make when joining a gym (and why "trying it out" is the worst strategy) -Identity shifts, community, healthy competition, and structure as mental stabilizers -Why hard training leads to better sleep — and why productivity beats busyness -The role of light exposure and outdoor training in mental health -Why exercise rivals SSRIs for treating depression and anxiety

What if the anxiety, overthinking, people pleasing, emotional shutdown, hypervigilance, burnout, and relationship struggles you experience today… were never actually "you" to begin with? In this deeply personal and profoundly eye-opening solo episode, Darin Olien dives into the hidden nervous system programming formed between the ages of 0 and 8 that silently shapes our adult lives. Drawing from neuroscience, trauma research, attachment theory, epigenetics, somatic healing, and his own emotional breakthroughs, Darin explores how childhood experiences become subconscious operating systems that influence everything from relationships and stress responses to chronic disease and self-worth. This episode is a powerful roadmap toward healing. Darin breaks down the science behind trauma, the ACE study, nervous system dysregulation, emotional patterning, and neuroplasticity, while also sharing practical tools like somatic experiencing, expressive writing, EMDR, and Internal Family Systems to help listeners begin rewiring their emotional lives from the inside out. What You'll Learn How childhood experiences program the nervous system Why most adult emotional reactions are subconscious survival patterns The connection between trauma, stress hormones, and chronic disease How the nervous system stores emotional experiences in the body Why people pleasing, hypervigilance, burnout, and emotional shutdown develop The science behind neuroplasticity and rewiring the brain What the ACE Study revealed about childhood trauma and adult health How trauma impacts the amygdala, hippocampus, and stress-response systems Why emotional patterns are adaptations, not character flaws How epigenetics can pass trauma responses across generations The role of somatic experiencing in trauma healing Practical tools for emotional regulation and nervous system repair Chapters 00:00:03 – Welcome to SuperLife 00:00:32 – Sponsor: Bite Toothpaste and eliminating toxic plastic exposure 00:02:47 – Darin introduces emotional reactions and nervous system triggers 00:03:15 – A personal story about reacting vs responding in conflict 00:03:50 – Emotional shutdowns, rage, withdrawal, people pleasing, and overcorrection 00:04:19 – Darin's physical pain journey and emotional discoveries in 2025 00:04:42 – Birth trauma, childhood conditioning, and nervous system programming 00:05:04 – Why the ages of 0–8 are the most neurologically influential years 00:05:18 – Theta and delta brainwave states during childhood 00:05:55 – How children absorb emotional patterns without filters 00:06:22 – Childhood experiences becoming subconscious operating systems 00:06:44 – Adults unknowingly living through a 5-year-old nervous system 00:07:12 – Why this episode became deeply personal for Darin 00:07:35 – The neuroscience behind stress responses and emotional conditioning 00:08:17 – Brain development, neuroplasticity, and subconscious programming 00:09:13 – How the HPA axis, amygdala, and prefrontal cortex are shaped early in life 00:09:45 – Core childhood questions that program the nervous system 00:10:29 – Why adult stress responses originate in childhood environments 00:11:05 – Research showing childhood adversity alters brain structure and chemistry 00:11:18 – The ACE Study explained 00:11:49 – Why patients losing weight became emotionally overwhelmed 00:12:18 – The ten categories of adverse childhood experiences 00:13:02 – "The health crisis of America begins in childhood" 00:13:36 – How adverse childhood experiences increase disease risk 00:14:03 – Suicide, alcoholism, autoimmune disease, depression, and trauma correlations 00:14:37 – Chronic disease as a nervous system issue 00:15:04 – Survival mode, inflammation, hormonal dysregulation, and emotional scarcity 00:15:42 – Self-sabotage and emotional coping patterns explained 00:16:02 – Why your emotional patterns are not character flaws 00:16:22 – Childhood survival adaptations and nervous system intelligence 00:16:52 – Hypervigilance, people pleasing, rage, emotional shutdown, and fear 00:17:05 – Sponsor: Manna Vitality and frequency-based wellness 00:18:59 – Epigenetics and inherited trauma responses 00:19:22 – Cortisol regulation genes and hyperactive stress responses 00:19:51 – Holocaust survivors, inherited trauma, and generational nervous systems 00:20:19 – Why healing requires nervous system awareness—not just intellectual understanding 00:20:45 – "You were never supposed to get over it—you were supposed to heal from it" 00:21:01 – Real-life examples of subconscious nervous system programming 00:21:16 – Why receiving compliments can feel unsafe 00:21:30 – Darin's personal struggle with overachievement and scarcity programming 00:22:03 – Emotional neglect, chronic striving, and feeling "not enough" 00:22:16 – The nervous system roots of burnout and exhaustion 00:22:23 – Hair-trigger emotional reactions and hyperactive amygdala responses 00:22:38 – Chronic self-abandonment and losing personal boundaries 00:22:52 – Fear of intimacy, trust issues, and emotional safety 00:23:02 – "The body keeps the score" explained 00:23:22 – Trauma stored in posture, breath, digestion, immunity, and emotional regulation 00:23:43 – Harvard research on trauma-related brain changes 00:24:19 – The radical power of neuroplasticity and nervous system rewiring 00:24:48 – Why healing requires conscious participation 00:25:01 – Darin shares how healing changed decades of emotional pain 00:25:33 – Somatic Experiencing and Peter Levine's trauma work 00:25:57 – How animals discharge stress naturally 00:26:23 – Trauma as incomplete physiological responses frozen in the body 00:26:42 – Why humans suppress emotional discharge 00:27:16 – PTSD research and the effectiveness of somatic experiencing 00:27:41 – A step-by-step somatic grounding practice 00:28:14 – Why healing is more powerful with a regulated person beside you 00:28:38 – EMDR and reprocessing traumatic experiences 00:28:55 – Internal Family Systems and the "parts" inside the psyche 00:29:13 – Inner critics, overachievers, and nervous system adaptations 00:29:39 – Compassionately listening to emotional parts instead of suppressing them 00:29:51 – Expressive writing as a trauma healing practice 00:30:22 – The neuroscience behind emotional journaling 00:30:48 – A four-day expressive writing protocol for healing 00:31:05 – "You are not broken" 00:31:16 – Reprogramming the nervous system through love and safety 00:31:37 – Why deep healing happens in the presence of another regulated person 00:31:52 – Darin considers creating a future healing workshop 00:32:04 – Final reflections: "You are not what happened to you" 00:32:12 – Peace. Love. SuperLife. Thank You to Our Sponsors Bite Toothpaste: Go to trybite.com/DARIN20 or use code DARIN20 for 20% off your first order Manna Vitality: Go to mannavitality.com/ and use code DARIN12 for 12% off your order. Join the SuperLife Patreon: This is where Darin now shares the deeper work: - weekly voice notes - ingredient trackers - wellness challenges - extended conversations - community accountability - sovereignty practices Join now for only $7.49/month at https://patreon.com/darinolien     Connect with Darin Olien: Website: darinolien.com Instagram: @darinolien Book: Fatal Conveniences Platform & Products: superlife.com New Show: Roadmap to Happiness Key Takeaway "The emotional patterns, fears, reactions, and coping mechanisms that run your adult life are often survival adaptations created by your nervous system during childhood. They are not your identity. They are not permanent. And through awareness, somatic healing, emotional processing, nervous system regulation, and conscious repetition, those deeply rooted patterns can be rewritten into something healthier, freer, and more aligned with who you truly are." Bibliography/Sources Neuroscience & Early Programming Agorastos, A., Pervanidou, P., Chrousos, G. P., & Baker, D. G. (2019). Developmental trajectories of early life stress and trauma: A narrative review on neurobiological aspects beyond stress system dysregulation. Frontiers in Psychiatry, 10, Article 118. https://doi.org/10.3389/fpsyt.2019.00118 Bolton, J. L., Short, A. K., Simeone, K. A., Daglian, J., & Baram, T. Z. (2019). Programming of stress-sensitive neurons and circuits by early-life experiences. Frontiers in Behavioral Neuroscience, 13, Article 30. https://doi.org/10.3389/fnbeh.2019.00030 Shonkoff, J. P., & Boyce, W. T. (2024). Toxic stress and developmental programming of the HPA axis. Annual Review of Developmental Psychology. https://www.annualreviews.org/journal/devpsych Teicher, M. H., & Ohashi, K. (2023). Childhood trauma and reduced hippocampal, anterior cingulate, and corpus callosum volumes. JAMA Psychiatry. https://jamanetwork.com/journals/jamapsychiatry van der Kolk, B. A. (2014). The body keeps the score: Brain, mind, and body in the healing of trauma. Viking / Penguin. https://www.penguinrandomhouse.com/books/313183/the-body-keeps-the-score-by-bessel-van-der-kolk-md/ ACE Study & Adverse Childhood Experiences Felitti, V. J. (2002). The relation between adverse childhood experiences and adult health: Turning gold into lead. The Permanente Journal, 6(1), 44–47. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112216/ Felitti, V. J., & Anda, R. F. (2010). The relationship of adverse childhood experiences to adult health, well-being, social function, and healthcare. In R. Lanius, E. Vermetten, & C. Pain (Eds.), The impact of early life trauma on health and disease (pp. 77–87). Cambridge University Press. https://doi.org/10.1017/CBO9780511777042 Hillis, S., Mercy, J., Amobi, A., & Kress, H. (2023). Economic burden of health conditions associated with adverse childhood experiences among U.S. adults. JAMA Network Open, 6(12). https://jamanetwork.com/journals/jamanetworkopen Liu, Y., Croft, J. B., Chapman, D. P., et al. (2013). Associations between adverse childhood experiences and health outcomes in adults aged 18–59 years. PLOS ONE, 8(3), e58625. https://doi.org/10.1371/journal.pone.0058625 Epigenetics & Trauma Baratta, M. V., et al. (2021). Epigenetics of childhood trauma: Long term sequelae and potential for treatment. Neuroscience & Biobehavioral Reviews, 132, 1049–1063. https://doi.org/10.1016/j.neubiorev.2021.09.043 Jiang, S., Postovit, L., Cattaneo, A., Binder, E. B., & Aitchison, K. J. (2019). Epigenetic modifications in stress response genes associated with childhood trauma. Frontiers in Psychiatry, 10, Article 808. https://doi.org/10.3389/fpsyt.2019.00808 Provençal, N., & Binder, E. B. (2015). The effects of early life stress on the epigenome: From the womb to adulthood and even before. Experimental Neurology, 268, 10–20. https://doi.org/10.1016/j.expneurol.2014.12.001 Healing Modalities — Research Brom, D., Stokar, Y., Lawi, C., et al. (2017). Somatic experiencing for posttraumatic stress disorder: A randomized controlled outcome study. Journal of Traumatic Stress, 30(3), 304–312. https://doi.org/10.1002/jts.22189 Fratarolli, J. (2006). Experimental disclosure and its moderators: A meta-analysis. Psychological Bulletin, 132(6), 823–865. https://doi.org/10.1037/0033-2909.132.6.823 Gilbert, P. (2009). The compassionate mind: A new approach to life's challenges. New Harbinger Publications. https://www.newharbinger.com/9781572248403/the-compassionate-mind/ Justice Resource Institute. (2022). Evaluation of the efficacy of Internal Family Systems (IFS) therapy for trauma-related symptoms among complexly traumatized adults. ClinicalTrials.gov Identifier: NCT05155930. https://clinicaltrials.gov/ct2/show/NCT05155930 Kuhfuß, M., Maldei, T., Hetmanek, A., & Baumann, N. (2021). Somatic experiencing — effectiveness and key factors of a body-oriented trauma therapy. European Journal of Psychotraumatology, 12(1), Article 1929023. https://doi.org/10.1080/20008198.2021.1929023 Levine, P. A. (2010). In an unspoken voice: How the body releases trauma and restores goodness. North Atlantic Books. https://www.northatlanticbooks.com/shop/in-an-unspoken-voice/ Neff, K. D., & Germer, C. K. (2013). A pilot study and randomized controlled trial of the Mindful Self-Compassion Program. Journal of Clinical Psychology, 69(1), 28–44. https://doi.org/10.1002/jclp.21923 Pennebaker, J. W. (1997). Writing about emotional experiences as a therapeutic process. Psychological Science, 8(3), 162–166. https://doi.org/10.1111/j.1467-9280.1997.tb00403.x Rodenburg, R., Benjamin, A., de Roos, C., Meijer, A. M., & Stams, G. J. (2009). Efficacy of EMDR in children: A meta-analysis. Clinical Psychology Review, 29(7), 599–606. https://doi.org/10.1016/j.cpr.2009.06.008 Schwartz, R. C. (2021). No bad parts: Healing trauma and restoring wholeness with the Internal Family Systems model. Sounds True. https://www.soundstrue.com/products/no-bad-parts Shapiro, F. (2017). Eye movement desensitization and reprocessing (EMDR) therapy: Basic principles, protocols, and procedures (3rd ed.). Guilford Press. https://www.guilford.com/books/Eye-Movement-Desensitization-and-Reprocessing/Francine-Shapiro/9781462532766  

We're in our Element of Resilience and we're going somewhere most mental health conversations completely skip: the heart.  Dr. Henry Emmons and Dr. Aimee Prasek unpack why mental health has been so brain-centric for so long, what the field of neurocardiology is revealing about the heart's role in how we feel, think, and connect, and why ancient healing traditions were frankly ahead of the curve on all of this. Then they walk through three practical, research-backed heart-centered practices to support your mental health: self-acceptance, loving-kindness, and compassion. Henry also shares a simple, portable exercise called The Three Kindnesses that you can do anywhere, anytime. Whether you've been with us throughout this series or this is your first episode, this one is a great entry point into what Joy Lab is really about.   Try It Free

Your relationships are reshaping your biology in ways that diet and exercise alone cannot fix, and the science behind it will change how you think about longevity, metabolism, and what it actually means to be healthy. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Molly Maloof, a physician and one of the most innovative voices in personalized medicine, functional medicine, and human performance. Since 2012, she has advised or consulted for over 50 companies across digital health, consumer health, and biotechnology. She pioneered a course on healthspan at Stanford University and founded Adamo Bioscience, a company dedicated to unlocking the science of love as a pathway to healing and human connection. Dr. Maloof brings a rare combination of clinical depth, biohacking credibility, and entrepreneurial range to one of the most overlooked conversations in longevity. Together, Dave and Dr. Maloof dig into the neurobiology of love and attachment, the hormonal drivers of the sex drive and pair bonding, and how chronic isolation wrecks your metabolism at the cellular level. They explore the cell danger response and how toxic relationships, mold exposure, and trauma can lock your cells into a self-protection mode that blocks healing. They also cover psychedelics as hormetic tools, oxytocin as nature's medicine, the placebo response, peptide therapy for mitochondrial repair and anti-aging, and why regenerative medicine is about to rewrite the rules of human lifespan. If you are serious about biohacking your body from the inside out, this episode is essential. You'll Learn: Why human connection is a biological necessity, not a lifestyle preference, and what isolation does to your mitochondria and metabolism How the three neurobiological drives of sex, romantic love, and attachment are wired into your hormones and what happens when they go wrong What the cell danger response is, why it gets stuck, and which peptides, supplements, and therapies help break the cycle How oxytocin drives wound healing, immune function, and the placebo response Why psychedelics work as hormetic love drugs and how they reproduce the neurobiology of romantic love The top peptides for mitochondrial repair, brain optimization, and telomere biology Why Dave and Dr. Maloof believe we have already reached longevity escape velocity How AI is accelerating precision medicine, protein folding breakthroughs, and the future of anti-aging therapeutics Why fasting, breathwork, neurofeedback, and somatic therapies all converge on the same biological reset mechanism How to build the adaptive capacity and bioenergetic reserves to bounce back from anything Thank you to our sponsors! - Danger Coffee | Grab yours at DangerCoffee.com and use code DAVEPOD at checkout for 15% off. - Amp | If you're ready to make fitness fit into your life, go to amp.ai to check it out - Puori | Go to Puori.com/DAVE or use code DAVE at checkout to get 32% off your Puori Fish Oil subscription. You save more than $18 - Our Place | Stop cooking with toxic cookware and upgrade to Our Place today. With a 100-day risk-free trial, plus free shipping and returns, you can experience this game-changing cookware with zero risk. Visit: fromourplace.com/DAVE Use code: DAVE for 10% off sitewide Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Dr. Molly Maloof, Adamo Bioscience, Stanford University, personalized medicine, functional medicine, healthspan, longevity, biohacking, human performance, anti-aging, regenerative medicine, longevity escape velocity, cell danger response, mitochondria, mitochondrial health, oxytocin, vasopressin, dopamine, serotonin, neurobiology of love, attachment theory, pair bonding, sex drive, hormone replacement therapy, testosterone, estrogen, menopause, andropause, libido, female sexual dysfunction, relationship biology, social health, isolation, community, co-regulation, trauma healing, psychedelics, MDMA, psilocybin, ibogaine, ayahuasca, hormetic stress, social hormesis, neurofeedback, 40 Years of Zen, breathwork, nervous system regulation, HPA axis, cortisol, mast cell activation, histamine, long COVID, mold exposure, phospholipid therapy, glutathione, vitamin C, BPC-157, TB500, SS31, epothilone, SELANK, SEMAX, BDNF, telomere biology, telomerase, peptides, GLP-1, placebo response, wound healing, metabolism, continuous glucose monitoring, gut health, AI, precision medicine, supplements, brain optimization, neuroplasticity Resources: • Grab Molly's Book The Spark Factor: https://www.amazon.com/Spark-Factor-Supercharging-Optimizing-Feeling/dp/0063207206 • Learn More About Dr. Molly's Work: https://drmolly.co/ • Visit Your Healthspan Journey: https://yourhealthspanjourney.mystrikingly.com/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:28 – Intro 01:39 – COVID Isolation & Its Effects 03:11 – Science of Love & Hormones 04:24 – Psychedelics & Love Chemistry 09:22 – Cell Danger Response 11:07 – AI, Tech & Human Connection 13:20 – Social Connection as Medicine 20:50 – Placebo, Care & Psychedelics 24:49 – Altered States & Healing Modalities 30:09 – Peptides & Longevity Drugs 35:44 – Mast Cell & Personal Health Challenges 43:46 – Regenerative Medicine & The Future 46:17 – Longevity Escape Velocity 50:05 – Outro See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Does GABA Actually Help With Sleep? What the Research Says for Brain Injury Recovery Someone in our community recently asked me about GABA for sleep. They’d seen it recommended online, understood that sleep was critical for their recovery, and wanted to know whether the supplement was worth exploring or just noise. It’s a genuinely good question. And it deserves a proper answer. In this post, I’m going to walk you through what GABA is, what the clinical research actually shows about its effect on sleep, why the blood-brain barrier debate matters (and why it might not derail the whole argument), and what the evidence says about the relationship between sleep and brain recovery. By the end, you’ll have enough to have an informed conversation with your medical team. I’m not a doctor. I’m a three-time haemorrhagic stroke survivor who has spent years researching the science of brain recovery and interviewing hundreds of clinicians and survivors on the Recovery After Stroke podcast. What I offer is a careful read of the evidence, not a clinical prescription. What Is GABA and Why Does It Matter for Sleep? GABA (gamma-aminobutyric acid) is the brain’s primary inhibitory neurotransmitter. If your nervous system were a car, GABA is the brake pedal. It reduces neuronal excitability, quiets cortical arousal, suppresses the brain’s primary arousal centre (the locus coeruleus), and modulates the HPA axis, the stress-response system that drives cortisol. Most sedative medications work by amplifying GABA activity. Benzodiazepines, for instance, bind to GABA-A receptors to increase chloride channel opening, producing their calming effect. GABA isn’t doing something unusual here – it’s doing something fundamental. The question with supplemental oral GABA is more specific: Does taking GABA as a capsule or powder actually produce meaningful neurological effects? What Does the Research Show? Finding 1 — Oral GABA Reduces Sleep Latency (and EEG Can Measure It) A 2015 clinical trial published in the Journal of Nutritional Science and Vitaminology by Yamatsu and colleagues used EEG measurement, actual brainwave monitoring, rather than self-reported sleep questionnaires. One hundred milligrams of oral GABA shortened sleep latency (time to fall asleep) by 5.3 minutes compared to placebo. That might sound modest. But for someone lying awake for 30–40 minutes each night, it’s a meaningful shift. Crucially, this was objective neurophysiological data, not a survey response. (PMID: 26052150) Finding 2 — A 90-Day RCT Showed Improved Sleep Efficiency and Mood A 2024 randomised double-blind placebo-controlled trial published in the Journal of Dietary Supplements (Guimarães et al.) gave 200 mg of GABA daily for 90 days to sedentary overweight women also undergoing an exercise program. The GABA group showed significantly improved Pittsburgh Sleep Quality Index (PSQI) scores, significantly reduced depression scores, and improved heart rate variability, a marker of parasympathetic nervous system activity. The HRV finding is particularly interesting. It suggests GABA may be doing something broader than simply reducing sleep latency – it appears to support the overall physiological state that makes rest restorative. (PMID: 38321713) Finding 3 — But a High-Dose RCT Found No Effect Here’s where intellectual honesty matters. A 2023 Dutch RCT (de Bie et al.) published in the American Journal of Clinical Nutrition gave participants 500 mg of GABA three times daily, 1,500 mg/day total, and found no significant effect on self-reported sleep quality. Fasting plasma GABA wasn’t significantly elevated either, raising real bioavailability questions at that dose. This isn’t a reason to dismiss GABA entirely. It is a reason to pay attention to the dose. The evidence base supports 100–300 mg, not 1,500 mg. Higher is not better, and the non-linear dose response is clinically important. (PMID: 37495019) The Blood-Brain Barrier Debate — and Why the Gut May Be the Point The most common objection to oral GABA supplementation is this: GABA is a zwitterion at physiological pH, meaning it has low lipophilicity and poor predicted ability to cross the blood-brain barrier via passive diffusion. So if it can’t get into the brain directly, how does it produce neurological effects? The emerging explanation involves the gut-brain axis. The enteric nervous system, your gut’s own neural network, has GABA receptors. When oral GABA activates these enteric receptors, it can signal the brain via vagal afferents without needing to cross the BBB at all. Think of it as a side door rather than the front entrance. Supporting this: a 2024 RCT (Li et al.) found that a probiotic strain engineered to increase gut GABA production significantly improved objective sleep duration as measured by wearable devices, alongside reduced cortisol and suppressed HPA axis activity. The mechanism wasn’t direct CNS access – it was gut-brain signalling. (PMID: 39385735) The BBB debate doesn’t negate the clinical effect. It changes how we understand the mechanism. Why Sleep Is Not Optional in Brain Recovery This is the part that I think gets underweighted in recovery conversations — and the research is unambiguous. A 2026 large retrospective cohort study (Muhtar et al., Sleep Medicine) matched over 35,000 stroke patients and found that post-stroke insomnia was associated with a 29% higher risk of post-stroke cognitive impairment and a 30% higher risk of all-cause dementia. The association with Alzheimer’s disease was also significant. (PMID: 41924789) A 2024 observational study from Monash University and Alfred Health (Smith et al.) found that in stroke rehabilitation patients, poor sleep quality was significantly associated with higher fatigue severity and lower salivary BDNF gene expression. BDNF (brain-derived neurotrophic factor) is one of the primary molecular drivers of neuroplasticity. Less BDNF means a less receptive environment for the neurological rewiring that rehab is trying to build. (PMID: 38802847) And then there’s the glymphatic system: the brain’s waste-clearance mechanism that is most active during deep sleep. Poor sleep means reduced clearance of metabolic byproducts, including proteins associated with neurodegeneration. This is not a theoretical risk. It is an active, ongoing process. Sleep is not passive recovery. It is one of the primary mechanisms of recovery. What to Do With This Information Here are three practical steps if you’re exploring GABA for sleep: 1. Measure your sleep baseline first. Use the Pittsburgh Sleep Quality Index (freely available online) before you make any changes. Understanding whether you’re struggling with latency, duration, or quality will determine what you actually need to address. 2. If you trial GABA, choose the right form and dose. Look for PharmaGABA — naturally fermented GABA, derived from Lactobacillus hilgardii, which has the strongest clinical evidence base. A dose of 100–300 mg taken 30–60 minutes before bed is consistent with the positive studies. Avoid very high doses; the null result at 1,500 mg/day is important context. Important drug interaction note: If you are taking benzodiazepines, anticonvulsants (gabapentin, pregabalin, valproate), or any other GABAergic medication, discuss GABA supplementation with your prescriber before adding it. The additive sedative effect is a real risk. The same applies if you drink alcohol regularly. 3. Don’t skip the foundation. Sleep hygiene interventions, consistent sleep and wake times, a dark and cool room, and no screens in the 60 minutes before bed, are consistently among the highest-leverage sleep interventions in the literature. GABA may provide a genuine incremental benefit. But it cannot compensate for a fundamentally disrupted sleep environment. The Bottom Line The evidence for GABA and sleep is more substantive than I expected when I started researching it. The EEG data is real. The 90-day RCT showed meaningful clinical outcomes. The gut-brain axis mechanism is biologically plausible and now has direct RCT support. And the consequences of poor sleep in neurological recovery are not trivial – they are quantifiable, significant, and, to a degree, addressable. GABA is not a guaranteed fix. Individual responses vary. The research is not yet definitive at the level of large multi-centre trials in neurological populations. But as one tool in a comprehensive approach to sleep quality alongside good sleep hygiene, appropriate medical support, and consistent rehabilitation, the case for cautious exploration is reasonable. The next step is a conversation with your neurologist, GP, or rehab physician. Take the research with you if it’s useful. Research References All studies cited in this post are retrievable via PubMed: Yamatsu et al. — GABA sleep latency EEG clinical trial (2015) — PMID: 26052150 Guimarães et al. — GABA 200mg RCT, sleep efficiency + mood (2024) — PMID: 38321713 de Bie et al. — GABA high-dose RCT, null sleep result (2023) — PMID: 37495019 Li et al. — Gut-brain GABA axis and sleep RCT (2024) — PMID: 39385735 Muhtar et al. — Post-stroke insomnia and cognitive decline cohort (2026) — PMID: 41924789 Smith et al. — Sleep, BDNF, and fatigue in stroke rehabilitation (2024) — PMID: 38802847 This post is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before making changes to your supplementation or treatment plan. If you or someone you care about is recovering from a stroke, brain injury, or any neurological condition, the Recovery After Stroke podcast and this blog exist for you. Subscribe on YouTube @BillGasiamis, or visit Recovery After Stroke to find episodes, resources, and community. The post GABA, Sleep, and Brain Health – Neurological Recovery appeared first on Recovery After Stroke.

What if healing wasn't about chasing symptoms… but restoring coherence? In this powerful episode, Dr. Fred Schofield dives deep into the philosophy, frequency, and function behind chiropractic care, and why so many people today are stuck living in survival mode instead of true alignment. Dr. Fred challenges doctors to stop going through the motions and start developing a deeper passion for analyzing, locating, and adjusting the subluxation with intention and certainty. He unpacks the importance of pre-checks and post-checks, the role of the nervous system in adaptability, and how true healing happens when the body is brought back into balance, not pushed too far sympathetic or parasympathetic. This episode also explores the overwhelming "noise" of modern life, how stress hijacks the glandular system and HPA axis, and why slowing down may actually be the key to greater energy, clarity, and practice growth. From hydration and morning rituals… to quantum physics, vibration, and chiropractic philosophy… this conversation is a reminder that healing starts when we reconnect to the frequency of life itself. If you've been feeling disconnected, overwhelmed, or simply going through the motions in practice or life, this episode will challenge you to recenter, refocus, and "expect a miracle." "Chiropractic adaptability is about bringing the body back into coherence" - Dr. Fred Keep Charging!! MoChihChu! Ask a Question for a Future Episode! Apply to work with our coaches! Join Susan's monthly CA webinars Join us at our next seminars! Join the Rhino Digital Training!

If you have clients doing everything right eating clean, cutting gluten and dairy, exercising consistently and they're still bloated, exhausted, and stuck, this episode is for you. I'm sitting down with gut health expert Hannah Aylward to talk about what's actually going on when food isn't the problem, what "leaky gut" really means, and what signs fitness coaches should watch for before referring clients out for deeper support.What You'll Discover:- Why food sensitivity tests are often misleading and what to look at instead- The truth about leaky gut — what the science actually says and how to identify root causes- How to differentiate fat, protein, and fiber reactivity in clients- The real story behind "adrenal fatigue" and HPA axis dysregulation- What signs tell a coach that a client needs deeper gut health support- Hannah's 80-85% compliance rule and why perfection sabotages results- How long gut healing actually takes at the root cause levelTimestamps:00:00 — Intro01:20 — Who is Hannah Aylward and what is HAN?04:15 — Why practitioners and coaches end up as clients07:30 — Hannah's personal gut health story13:45 — Why food isn't usually the root cause of reactions20:00 — How to read fat, protein, and fiber reactivity patterns25:30 — The dairy, lactose, and casein question30:10 — Is leaky gut real? Breaking down intestinal permeability37:20 — Adrenal fatigue vs. HPA axis dysregulation43:00 — Signs coaches should watch for in clients48:15 — The "I'm fine" coma — normalizing feeling bad54:00 — Navigating perfectionism with clients59:30 — How long does gut healing actually take?63:00 — Where to find HannahResources Mentioned:Hannah Aylward Nutrition: https://hannahaylward.com- Hannah on Instagram: https://www.instagram.com/hannahaylwardhhc/- The Nutrient Dense Podcast: https://podcasts.apple.com/us/podcast/the-nutrient-dense-podcast/id1788408977Resources & Links MentionedWant more client leads on Instagram™?  Grab lifetime access to 90- Days Done for You that Converts: https://ptprofitformula.com/content

In this episode of the Joy Lab Podcast, Dr. Aimee Prasek and Dr. Henry Emmons dig into one of the most counterintuitive resilience skills we can build: turning toward negative emotions instead of running from them. This isn't about wallowing. It's about befriending the feelings that are already there so they can actually move through you, instead of getting lodged and piling up.  We're talking fear (the emotion at the core of so many others), the science of emotions vs. feelings, why your emotional immune system needs exposure to develop, and three grounded steps (embody, observe, yield) to help you navigate the next emotional flurry before it becomes a blizzard. This one pairs beautifully with our Grief Series (starting at Episode 248) and our last episode on the observer self. Whether you're new to this work or deep in it, there's something here for you.   Try It Free

Happiness isn't a nonstop high. For us, the real win is an elevated baseline: that steady, grounded sense of wellness that makes you more resilient, less reactive, and far harder to knock off course when a day goes sideways.We unpack why that baseline is built less by hype and more by biology. I share why omega-3 fatty acids matter so much for mental health, mood, and brain function, especially the marine forms EPA and DHA. We talk about how your brain relies on healthy fats for cell membrane function, why omega-3s are often discussed in relation to depression support, and how they can influence stress response through the HPA axis and cortisol regulation. If you've ever wondered why you can “know” the right mindset but still feel anxious, flat, or tangled in your emotions, this is the missing link: the state of your body shapes the state of your mind.Beyond the non-negotiables of quality sleep, exercise, and balanced meals that meet real nutrient requirements, I lay out a simple, evidence-based supplement routine your brain and body need to make the chemicals tied to motivation, focus, and calm. This is unglamorous work, but it's the work that makes thriving feel repeatable.If this helped you, subscribe, share it with one person who needs an elevated baseline, and leave a rating and review so more people can find the tools to feel better every day.Text Me Your Thoughts and IdeasSupport the showBrought to you by Angela Shurina  Certified Health, Sleep, Performance & Executive Coach 360 with 18 years of experience helping people change to feel, be and do their best.

Cortisol after cancer is the conversation nobody on my care team had with me. I was diagnosed with breast cancer in 2021 — invasive ductal carcinoma, stage one, grade two. I went through lumpectomy, radiation, ovarian suppression, and two years on an aromatase inhibitor before I had to come off because my bones were already in osteoporosis. Throughout all of it, my nervous system was screaming. My cortisol was running hot all day long, confirmed by a Dutch test. And not one doctor told me what stress was doing to my body or how to mitigate it. In this solo episode of Not Today Cancer, I'm walking you through the seven activities that lowered my cortisol...broken into the things that don't cost a dime (meditation, breathwork, walking outside, unplugging) and the things that do (acupuncture, energy healing, therapy). I'm also sharing the actual research behind each one, so you know this isn't woo...it's documented science.  What you'll learn: • Why cortisol is wrecked after a cancer diagnosis (and why mine was high long before) • The symptoms of high cortisol most breast cancer survivors miss • How mindfulness meditation protected the cortisol rhythm of breast cancer survivors in a randomized controlled trial • Why a single session of slow breathing drops cortisol immediately • The "nature pill" research showing 20–30 minutes outside lowers cortisol 21% per hour • Why the NCCN officially recommends acupuncture for cancer survivors If you're a breast cancer survivor, caregiver, or anyone whose body has been running on fumes...this episode is for you. We don't get the option of not mitigating stress. Pick one thing on this list and start tomorrow. Disclaimer: This episode reflects my personal experience and a summary of public research. It is not medical advice. Always consult your care team.

I'm kicking off the brand-new Her Stack series — a women's health-focused series designed to break down common goals through nutrition, lifestyle, biohacking, supplements, and peptides. Today's focus is energy: why so many women feel tired, wired, depleted, or stuck in the afternoon crash cycle, and what it actually takes to rebuild energy from the foundation up. I talk about mitochondrial health, circadian rhythm, HPA axis dysregulation, postpartum and perimenopause-related energy shifts, hydration, protein, sleep, movement, peptides, and the 12-week framework I would use to start feeling like yourself again. Join The LongHer Life for women-specific guidance on peptides, hormones, and longevity. I TALK ABOUT:  01:25 - Why Her Stack is built around women's health, longevity, and four core pillars 03:05 - Why low energy is the number one complaint I hear from women 10:55 - Why postpartum and perimenopause can create major energy shifts 12:20 - Simple questions to help you assess whether your energy is actually broken 15:25 - Key data points to track, including HRV, resting heart rate, body temperature, and sleep stages 19:00 - Labs to consider when fatigue, brain fog, or hormone changes are showing up 21:40 - Why nutrition is the foundation before supplements or peptides 28:40 - Why hydration and minerals matter more than just drinking plain water 34:50 - Mitochondrial nutrients that support energy production 39:35 - Morning sunlight, blue blockers, and sleep routines for circadian health 44:50 - How grounding may support cortisol, HRV, and inflammation 45:30 - Why Zone 2 cardio and heavy lifting are essential for women's energy and longevity 53:50 - Fringe and cutting-edge biohacks, including methylene blue, hyperbaric oxygen, ketamine therapy, and EMF mitigation 59:10 - Foundational supplements for energy, cognition, and mitochondrial health 1:04:10 - Peptides for energy, inflammation, stress, mitochondria, and recovery 1:14:40 - How peptide protocols may shift across postpartum, perimenopause, menopause, and breastfeeding 1:15:50 - The 12-week energy rebuilding plan 1:20:00 - Why energy restoration requires a holistic approach, not one quick fix RESOURCES: Join The LongHer Life for women-specific guidance on peptides, hormones, and longevity. Free Peptide Masterclass for Women: Join the waitlist for the next live class. The Her Stack Planner: The first peptide tracking journal built around female biology. PRODUCTS MENTIONED IN THIS EPISODE: Peptide Serum for Women Waitlist: Early access and founder's pricing. SiPhox Health At Home Blood Testing (code: BRITTANY10) Baja Gold Salt Mineral Sea Salt (code: BIOHACKINGBRITTANY) BiOptimizers Gut & Performance Supplements (code: BIOHACKINGBRITTANY) Filter Optix Blue Light Blocking Glasses (code: BIOHACKINGBRITTANY) HigherDOSE Red Light Therapy (code: BRITTANY15)  Pulsetto Vagus Nerve Stimulation (code: BIOHACKINGBRITTANY) Kineon Red Light Therapy (code: BIOHACKINGBRITTANY) Leela Quantum Tech EMF Protection (code: BIOHACKINGBRITTANY) Defender Shield EMF Protection (code: BIOHACKINGBRITTANY) Juunaday EMF Protection Clothes For Women (code: BRITTANY) Timeline Nutrition Mitochondria Supplement (code: BIOHACKINGBRITTANY) NOVOS Longevity Supplement (code: BIOHACKINGBRITTANY) Nuchido Time+ NAD+ Supplement (code: BIOHACKINGBRITTANY) LET'S CONNECT: Instagram, TikTok, Facebook Shop my favorite health products Listen on Spotify, Apple Podcasts, YouTube Music

Calming the mind sounds simple, right? And yet most of us would rather do almost anything other than sitting quietly with our thoughts. In this episode, Dr. Aimee Prasek and Dr. Henry Emmons dig into the science of Automatic Negative Thoughts (ANTs), the surprising research on just how much we think, and the powerful practice of the observer self: the part of your mind that can step back, see what's happening, and choose differently. This episode makes the case that our relationship with our own minds might be the most important resilience work we do.   Try It Free

Sleep and weight gain are directly connected. Poor sleep disrupts hormones, raises blood sugar, tanks testosterone and estrogen, causes fatty liver, and wrecks your gut. If you've been doing everything right and the scale won't move, your sleep could be the missing link. FEATURED PRODUCT Chill by MSW Nutrition is a powdered drink mix formulated to support your body's natural calming chemistry — exactly what's needed when chronic stress and cortisol overload are stealing your sleep. Featuring GABA, L-Theanine, myo-Inositol, Taurine, and Magnesium, Chill helps balance neurotransmitters, quiet the nervous system, and promote the deep, restorative sleep your hormones, metabolism, and weight depend on — all five mechanisms discussed in this episode.

What does it actually mean to be resilient? Spoiler: it's not about white-knuckling through hard times or being the type of person who just 'endures' everything. In this episode, Dr. Aimee Prasek and Dr. Henry Emmons kick off Joy Lab's month-long exploration of Resilience. They'll share a science-grounded, warmly human look at what resilience really is, where it comes from, what depletes it, and, most importantly how to keep filling it back up. About: The Joy Lab Podcast blends science and soul to help you cope better with stress, ease anxiety, and uplift mood. Join Dr. Henry Emmons and Dr. Aimee Prasek for practical, mindfulness-based tools and positive psychology strategies to build resilience and create lasting joy. If you enjoyed this episode, please rate and review us wherever you listen to your favorite podcasts!   Important notes: Joy Lab Program: Take the next leap in your wellbeing journey with step-by-step practices to help you build and maintain the elements of joy in your life. Subscribe to our Newsletter: Join us over at Joylab.coach for exclusive emails, updates, and additional strategies.   Like and follow Joy Lab on Socials:  Instagram TikTok Linkedin Watch this episode on YouTube   Key moments: [00:00:00] — Welcome & introduce Resilience as this month's Element of Joy. [00:00:35] — Defining Resilience: Dr. Catherine Panter-Brick's definition: "a process to harness resources to sustain wellbeing" Resilience isn't a fixed state; it doesn't require the absence of illness, a certain mood, or a feeling of confidence. You can be resilient even when you feel completely unresilient. [00:01:40] — Henry's Take: Resilience as a Natural, Inborn Quality Henry frames resilience as something every human already carries — we wouldn't be here without it. He describes it as a capacity to face life's challenges with enough skill to deal with them "more or less successfully" (emphasis on more or less), get back up after being knocked down, and still hold onto some equanimity and connection to joy. [00:03:20] — Why Equanimity and Joy Are Part of Real Resilience: Aimee highlights that joy and equanimity aren't commonly included in definitions of resilience — and argues they should be. She makes the case that teaching people to simply endure hardship without attending to their relationship with it leads to only survival, not wellbeing. Personal story: her family's history of survival alongside deep, untended grief. [00:05:25] — The Research: Resilience Is Inborn and Universal- Aimee reviews longitudinal research on resilience: no single demographic, personality trait, or biological factor strongly predicts resilience. Chronic stress and difficult childhoods can "dent or delay" it, but they don't break it. The Joy Lab approach: tapping into the factors that boost resilience in meaningful, joyful ways. [00:07:10] — Henry's "Resilience Container" Model: Henry introduces a central metaphor for the episode- imagine a container in your brain/body holding a "magical elixir" that keeps you afloat. The size of that container differs between people — influenced by genetics and early environment. But the most important thing isn't container size — it's how well you keep refilling it. [00:08:10] — Factor #1: Genetics. Some resilience (and vulnerability) runs in families. Depression, for example, has a clear genetic component — but it's one piece of a much larger picture, not a sentence. [00:08:50] — Factor #2: Early Environment. How safe, nurtured, and emotionally respected we felt as children sets a tone for our emotional life. It's not something we can change retroactively, but its impact doesn't have to be permanent. Joy Lab's work is explicitly about shifting that emotional set point. [00:10:30] — Nobody Is Immune — But That's Not the End of the Story. Even the most naturally resilient person can be brought to their knees by a relentless string of losses or prolonged stress. The goal: reduce the drain and actively refill. It's a dynamic system. [00:11:50] — You Have to Test Resilience to Build It: The Biosphere 2 Story Aimee tells the story of Biosphere 2, the closed experimental ecosystem in Arizona — where trees given perfect growing conditions (no wind, no stress) grew fast and then simply collapsed. Scientists eventually discovered that wind stress causes trees to form stress wood (reaction wood): dense, concentrated cells that structurally reinforce the tree.  [00:13:55] — Eustress: The Good Stress That Builds You Up. Aimee introduces eustress (eu = Greek for "good") — the kind of stress that actually strengthens us. Like exercise for muscles, or cardiovascular training: the system doesn't improve without being challenged. Our nervous systems, emotional resilience, and capacity to handle difficulty follow the same pattern. You are biologically laying down stronger capacity every time you navigate a challenge and come through the other side. [00:16:10] — Stress Isn't the Enemy — Imbalance Is. Henry clarifies: stress itself isn't the problem. It becomes a problem when it's too intense, lasts too long, or when we don't respond to it well. Our bodies are built to handle stress — in appropriate doses. [00:16:50] — The Brain Chemistry of Resilience: Norepinephrine & Serotonin. Henry breaks down two key neurochemicals: norepinephrine (the brain's version of adrenaline — activates focus and alertness under stress) and serotonin (his candidate for the "magic elixir" in the resilience container — a coolant that counterbalances overactivation). When these get depleted or thrown out of balance by chronic stress, we feel it — sluggish, run-down, depressed. [00:18:20] — Our Collective Resilience Depletion Right Now. Henry names what many are feeling: after years of pandemic stress, ongoing political turmoil, and a relentless churn of bad news, people are depleted on a large scale. What began as activation has, over time, curdled into exhaustion. This is a collective resilience crisis — and it calls for collective attention. [00:19:40] — Aimee on Equanimity and Agency in Brain Chemistry. Aimee connects the brain chemistry back to the equanimity point: even at the biological level, we have influence. This is self-care with scientific grounding. She invites listeners into the Joy Lab Program (free through the month of May 2026) to put these ideas into practice. [00:21:30] — Closing Quote: Alan Watts on Your Inborn Nature .Aimee closes with a reflection from Alan Watts on seeing yourself as part of nature — as extraordinary and as fundamental as trees, clouds, fire, and galaxies. A reminder that your resilience isn't something you have to earn. It's already what you are.   Sources and Notes: Joy Lab Program: Take the next leap in your wellbeing journey with step-by-step practices to help you build and maintain the elements of joy in your life. Chemistry of Calm (Dr. Emmons' book referenced in this series) Dr. Catherine Panter-Brick- Yale faculty page Resilience definitions, theory, and challenges: interdisciplinary perspectives Annual Research Review: Positive adjustment to adversity -Trajectories of minimal-impact resilience and emergent resilience Effects of a 12-week endurance training program on the physiological response to psychosocial stress in men: a randomized controlled trial No man is an island: social resources, stress and mental health at mid-life How does the brain deal with cumulative stress? A review with focus on developmental stress, HPA axis function and hippocampal structure in humans Just think: The challenges of the disengaged mind (this is the study of people shocking themselves out of boredom) Emotion Suppression and Mortality Risk Over a 12-Year Follow-up Cumulative Stress and Health The Times of Our Lives: Interaction Among Different Biological Periodicities      Full transcript here.   Please remember that this content is for informational and educational purposes only. It is not intended to provide medical advice and is not a replacement for advice and treatment from a medical professional. Please consult your doctor or other qualified health professional before beginning any diet change, supplement, or lifestyle program. Please see our terms for more information. If you or someone you know is struggling or in crisis, help is available. Call the NAMI HelpLine: 1-800-950-6264 available Monday through Friday, 10 a.m. – 10 p.m., ET. OR text "HelpLine" to 62640 or email NAMI at helpline@nami.org. Visit NAMI for more. You can also call or text SAMHSA at 988 or chat 988lifeline.org.

Beyond the NICU: How Small Moments Shape a Developing BrainHow early experiences and neuroprotective care shape brain development and long-term outcomesWhat happens in the NICU does not end at discharge. In this episode, we take a deeper look at the lasting impact of NICU care and how early experiences shape a child's brain development and long-term outcomes. While many are familiar with the major complications of prematurity, we explore the often less visible—and frequently underestimated—effects sometimes referred to as “minor" or co- morbidities, and why there is nothing minor about their impact.We discuss how the premature brain is still developing, how stress and the NICU environment influence that development, and what happens when the stress response system develops under stress. More importantly, we walk through tangible, practical ways—core measures drawn from established models and frameworks—that support neuroprotective, family-centered, and developmentally supportive care in the NICU.This episode is for both NICU parents and clinicians. If you are a current NICU parent, you'll learn ways you can actively support your baby and feel more confident in your role. If your child is a NICU graduate, this episode may help explain some of the experiences and challenges you've seen—and remind you that you are not alone. And for clinicians, this is a powerful reminder of the impact you have every single day, and how small, intentional choices can shape the trajectory of a child's life.Because NICU care is not just about survival. It's about how we help these children grow, develop, and thrive long after they go home.Dr. Brown's Medical: https://www.drbrownsmedical.com  The Infant-Driven Feeding™ (IDF) Program: https://www.infantdrivenfeeding.com/ Our NICU Roadmap: A Comprehensive NICU Journal: https://empoweringnicuparents.com/nicujournal/  NICU Mama Hats: https://empoweringnicuparents.com/hats/  NICU Milestone Cards: https://empoweringnicuparents.com/nicuproducts/  Newborn Holiday Cards: https://empoweringnicuparents.com/shop/  Empowering NICU Parents Show Notes: https://empoweringnicuparents.com/shownotes/  Episode 80 Show Notes: https://empoweringnicuparents.com/episode80  Empowering NICU Parents Instagram: https://www.instagram.com/empoweringnicuparents/  Empowering NICU Parents FB Group: https://www.facebook.com/groups/empoweringnicuparents  Pinterest Page: https://pin.it/36MJjmHThank you for listening to the Empowering NICU Parents Podcast. Be sure to subscribe and leave us a review—it helps other families find us. We're grateful to be part of this incredible community. Visit www.empoweringnicuparents.com for resources and support.

Why do you remember your most stressful moments so vividly but can't recall what you had for lunch last Tuesday? It's all about the limbic system. In this Jack Westin MCAT Podcast episode, Mike and Molly break down the biology of emotion and stress, covering every limbic system structure, the HPA axis, cortisol, and general adaptation syndrome, plus how all of it directly applies to surviving your MCAT prep without burning out.Get started with our resources!

On today's episode, I break down the brain circuits behind anxiety—the amygdala, hippocampus, prefrontal cortex, and the HPA axis—and show how they create panic, overgeneralization, and sleeplessness. I then explain, in plain terms, why anxiety feels overwhelming and how chronic stress weakens the brain's safety signals. The episode also outlines practical recovery steps, especially exposure therapy: intentionally facing feared situations, creating prediction errors, and building new safety memories so the prefrontal cortex and hippocampus can override the alarm. It's a clear roadmap for moving from fear to freedom.   —The Anxiety Recovery Program— https://unpluganxiety.com/my-program/ —1 on 1 Coaching— https://unpluganxiety.com/1-on-1-coaching/ —The Website— https://unpluganxiety.com

Send us Fan MailNight vision keeps getting smarter, but our brains do not update on the same schedule. We're joined by defense expert Alan Kearney, a former Irish Defence Forces officer who now works in European defense industry, to explore a problem that reaches far beyond goggles and helmets: what happens when advanced soldier systems outpace human cognition in the exact moments stress is highest?We start with the fundamentals of modern night vision and thermal fusion, then move into the messy reality of human performance. Under lethal threat, the sympathetic response and HPA axis change attention, memory, and perception. That's where latency, digital overlays, AI cueing, and networked data can become more than “extra information” they can become friction. We talk human factors engineering, cognitive load, pattern recognition, and why an information feed is not the same thing as situational awareness.From aviation lessons to procurement-room demo traps, we pressure-test the assumptions behind modernization. We also dig into mission command and the risks that come with total visibility, plus the long-term cost of over-reliance on tools that quietly erode core skills. The takeaway is not anti-tech. It's a human-first approach: design systems that match neurobiology, and raise the baseline with realistic training and training to failure so warfighters are never learning the hard way.If you care about military readiness, law enforcement performance, or how people make decisions under pressure, subscribe, share this with a friend, and leave a review with the biggest tradeoff you've seen between “more tech” and “better performance.”Alans Article: https://mwi.westpoint.edu/night-vision-at-a-crossroads-when-technology-outpaces-the-neurobiology-of-close-combat/Support the showWebsite: https://thehumanbehaviorpodcast.buzzsprout.com/shareFacebook: https://www.facebook.com/TheHumanBehaviorPodcastInstagram: https://www.instagram.com/thehumanbehaviorpodcast/Patreon: https://www.patreon.com/ArcadiaCogneratiMore about Greg and Brian: https://arcadiacognerati.com/arcadia-cognerati-leadership-team/ 

In this Mini Mikkipedia episode, Mikki unpacks one of the most common yet misunderstood issues in modern health: the interplay between cortisol, stress, poor sleep, and elevated heart rate. Using a real community question as the foundation, she explains why feeling “wired but tired” isn't a personal failing, but a physiological response to chronic, unresolved stress.Mikki walks through how cortisol actually works, why both exercise and life stress use the same biological pathways, and what happens when your system never fully downregulates. She also explores the role of the HPA axis, autonomic nervous system imbalance, and why tools like HRV and resting heart rate can offer insight—but also create more stress if misused.Most importantly, this episode delivers practical, evidence-based strategies to help restore balance and build resilience. Key Highlights: Why cortisol is not the villain—and what it actually does  The difference between acute stress and chronic, unresolved stress  What a high morning heart rate is really telling you  How lifestyle, hydration, and training load impact your stress response  Practical tools to downregulate your nervous system Contact Mikki:https://mikkiwilliden.com/https://www.facebook.com/mikkiwillidennutritionhttps://www.instagram.com/mikkiwilliden/https://linktr.ee/mikkiwillidenNZ listeners - save 10% off Calocurb by using the code Mikkipedia10 at www.calocurb.co.nzSave 20% on all Nuzest Products WORLDWIDE with the code MIKKI at www.nuzest.co.nz, www.nuzest.com.au or www.nuzest.comCurranz supplement: MIKKI saves you 25% at www.curranz.co.nz or www.curranz.co.uk off your first order

This conversation is one I've been wanting to have for a long time.I invited Robyn Kievit onto the podcast because she is doing something genuinely rare. She is the first dietician to become a nurse practitioner, she specialises in eating disorders, disordered eating and body image, and over the past several years she has become deeply educated in hormone therapy and perimenopause. She is one of very few clinicians in the world looking at all of this together, as one whole picture. And that matters enormously for the women I work with.We talk about what perimenopause actually feels like, why the hormonal shifts of this life phase can cause eating disorder symptoms to surge, what hormone therapy is and who it might help, and why so many women are being dismissed by their doctors when they deserve so much better. We also talk about body image, aging, grief, and what it means to enter this next season of life with compassion rather than resistance.This episode is for you if:You're in perimenopause or approaching it and want to understand what's actually happening in your bodyYour anxiety, depression or eating disorder symptoms have surged and you don't know whyYou've been dismissed by a doctor and told it's too early to seek supportYou have a history of an eating disorder and want to understand how that intersects with hormonal changesYou're struggling with body image as your body changes with ageYou want to know your options, natural, hormonal, and otherwise, for supporting yourself through this transitionYou believe, like I do, that you don't have to just white-knuckle your way through thisIn this episode, we cover:✨ The signs of perimenopause that often get missed or dismissed, and why they matter✨ How hormonal changes affect mood, sleep, cognition and anxiety in ways that are genuinely physiological, not just in your head✨ Why anxiety and depression can surge during perimenopause, especially if you have a history of either✨ The HPA and HPO axes explained in plain English, and why they're so central to how you feel during this transition✨ What hormone therapy actually is, who it can help, and what the current guidance really says✨ Why birth control pills and IUDs are considered hormone therapy, and what that means for you✨ The enormous gap in clinical education around eating disorders and menopause, and why Robyn created her course to address it✨ How to advocate for yourself if you're being dismissed by a doctor✨ Why bone health and cardiovascular health make hormonal support even more important for women with eating disorder histories✨ The body image and grief piece of aging, and why our bodies changing is not something to be corrected✨ What it means to enter the archetype of the crone, the wise woman, with self-compassion rather than fear✨ Why you are allowed to ask not to be weighed at a medical appointment✨ Robyn's course for clinicians and why it existsPowerful quotes from the episode:

Dr. Deb Muth February 2026, 3 million documents released, a network exposed. But here’s what no one is sayingThe trauma of trafficking doesn’t end when the victim escapes It doesn’t even end when that survivor’s lifetime. It writes itself into DNA. It alters the stress response of children not yet born. And it creates epigenetic markers that echo through 3, 4, and even 5 generations. This is not a metaphor, this is molecular biology. And if we don’t understand how deeply trauma sees itself. Biologically, genetically, and spiritually, we will never understand why autoimmune disease, addiction, and chronic illness are epidemic in families that carry this hidden history. Today, we’re going deeper than headlines. We’re going into the cells, the genes, and the soul. Welcome back to Let’s Talk Wellness Now. We’re here to uncover root causes, explore regenerative medicine, and empower you to heal from the inside out. I’m Dr. Deb, your medical detective, and today we’re confronting one of the most important and least discussed wellness topics of our time. How the exploitation and trafficking of women and children doesn’t just harm individuals, it damages bloodlines. And if you’re someone who carries an unexplained chronic illness, autoimmune disease, addiction, or trauma that seems to have no clear origin, this episode may finally connect the dots. Grab your cup of tea or coffee, settle in, and let’s go deep into this subject. Can you put an ad sponsor right here before we get started? Let’s start with what just happened. In February of 2026, the Department of Justice released over 3 million pages of documents related to Jeffrey Epstein. According to The Guardian, on February 2nd, 2026, these files contained allegations that Epstein didn’t just abuse women, he provided them to other powerful men. One accuser identified Harvey Weinstein from a photo lineup. Describing coercion and payment. Another FBI document described threats of force. Lativia launched a criminal investigation after the files linked Epstein’s network to modeling agencies overseas. But here’s what I need you to understand. As a practitioner who treats trauma survivors, Epstein’s operation was not new. It was ancient. From Mesopotamian slave codes to Roman markets to the transatlantic trade, trafficking has always been about the same thing. Power, and exploiting vulnerability for profit. The tools change. Private jets instead of ships, social media instead of market squares. But the wound, it’s identical. And that wound… It doesn’t heal when the victim is freed. It embeds itself into biology. Let me explain what happens when a human being experiences the kind of trauma that trafficking creates. The immediate biological response. When someone is trafficked, their body enters a state of chronic survival mode. The autonomic nervous system, which controls unconscious functions like heart rate, digestion, immune response, it gets locked into a fight or flight. Cortisol, the primary stress hormone, floods the system. At least, at first. This is protective. But when the threat never ends, when abuse is daily, when escape is impossible, cortisol stays elevated for months and even years. And here’s what chronic cortisol does. It suppresses immune function, making the body vulnerable to infections, cancer, and autoimmune disease. It disrupts the gut microbiome, leading to leaky gut, food sensitivity, and systemic inflammation. It dysregulates hormone production, thyroid sex hormones, insulin, and it creates metabolic chaos. It damages the hippocampus, the part of the brain region responsible for memory and emotional regulation. But it goes deeper than that. Cellular memory, trauma written into our tissues. Research published in the Biological Psychiatry of 2025 and Frontiers in Psychiatry 2025 shows that trauma doesn’t just affect the brain, it reprograms cells throughout the body. Mitochondria, the energy factories inside every cell, shift from producing ATP energy to producing reactive oxygen species, stress signals. This is why trauma survivors often develop chronic fatigue syndrome. That cortisol, over time, starts to dive down, and eventually can’t be produced when it’s supposed to be during a traumatic episode, and it stays at this low level, creating what we now know as chronic fatigue syndrome. Inflammatory genes turn on and stay on, even after the threat is gone. This is why we see such high rates of autoimmune disease, lupus, rheumatoid arthritis, MS, inflammatory bowel disease, in trafficking survivors. The fascia, the connective tissue that wraps every muscle and organ, stores trauma physically. This is why survivors develop chronic pain, fibromyalgia, and tension that no amount of massage can release. The body literally remembers the violation at a cellular level. The ACE study, Childhood Trauma as a Disease Predictor, the CDC’s Adverse Childhood Experiences Study in 2025, showed that 64% of the U.S. adults had experienced at least one ACE abuse. neglect, or household dysfunction. And nearly 1 in 6 has experienced 4 or more. And the data is devastating. The ACE that you have maybe experienced, if you have had this, you have a higher risk for heart disease, stroke, cancer, diabetes, autoimmune disease, depression, suicide, and addiction. Trafficking survivors often score 8, 9, or 10 out of a 10 on the ACE scale. Their bodies are biologically aged by trauma. And according to the VA’s National Center for PTSD, PTSD is associated with excess mortality, meaning survivors die younger, not just from suicide, but from the stress related to chronic disease. Now, here’s where it gets even more profound. What is epigenetics? Well, your DNA is like a library of instructions, but not every book is open all the time. Epigenetics is the system that decides which genes get turned on. or off, without changing the DNA sequence itself. And here’s the critical discovery. Trauma can change those epigenetic marks, and those marks can be passed to your children. The Science of Inherited Trauma. The studies on the Holocaust survivors and their descendants showed that children and grandchildren of trauma survivors had altered stress hormone regulation, even though they never experienced the original trauma themselves. Research on famine shows in the Netherlands during World War II, Found that children born to mothers who were pregnant during starvation had higher rates of obesity, diabetes, and heart disease decades later. This happens because stress during pregnancy alters the developing fetus’ stress response system, and when a pregnant woman is trafficked, abused, or living in chronic fear, her elevated cortisol levels cross the placenta, and the baby’s developing brain is bathed in stress hormones. And the child’s HPA access, the stress regulation system, Is programmed for hypervigilance. The child is born with a biological predisposition to anxiety, depression, autoimmune disease, and addiction. And it doesn’t stop there. That child grows up, and if they have children, their altered stress response can influence the next generation through epigenetic inheritance, and through the environment they create. This is why we see patterns of addiction, autoimmune disease, and mental illness running through families, even when there’s no clear genetic mutation. It’s not just genetics, it’s inherited trauma written into gene expression. There is also a spiritual dimension to this. There’s something beyond biology here, something that science is only beginning to touch. Survivors often describe feeling disconnected from their bodies, as if their spirit left during the abuse. And never fully returned. This is disassociation, a survival mechanism. But in many healing traditions, somatic therapy, internal family systems, even ancient spiritual practices, there’s recognition that trauma fragments the self. And healing isn’t just about regulating cortisol or repairing the gut, it’s about reuniting the spirit with the body. It’s about teaching the nervous system that it’s finally safe to be fully present once again. And when that happens, when one person heals that fracture, it changes the trajectory for everyone else who comes after them. So what do we do with this knowledge? Well, first. Trauma-informed root cause medicine. Healing trafficking survivors and their descendants requires more than talk therapy. It requires nervous system regulation, vagal nerve stimulation, somatic experience, breathwork. Gut healing, repairing the microbiome, addressing that leaky gut, and reducing the inflammation. Hormone balancing, supporting adrenal function, thyroid, and sex hormones, detoxification, clearing accumulated toxins that the stressed body couldn’t process, both physically and emotionally. Nutritional restoration. Replenishing the nutrients depleted by chronic stress. This is functional medicine. This is what I do every day with my team. Second, we need epigenetic reversal, and that is actually possible. Here’s the hope. Epigenetic marks can be changed. Studies show that meditation therapy, safe relationships, and even nutrition can reverse some of the epigenetic damage caused by trauma. Every time a survivor learns to regulate their nervous system, they’re not just healing themselves, they’re changing what gets passed to the next generation. Third, we have to speak the truth. Silence protects the perpetrators. Truth-telling breaks generational curses. And every time we name trafficking for what it is, a crime that damages biology, genetics, and spirit, we create the space for healing. Thank you for going deep with me today on Let’s Talk Wellness Now. If this episode moved you, share it, because healing begins when we stop pretending trauma is only psychological, and we start treating it as a biological, genetic, and spiritual crisis that it truly is. If you or someone you love needs trauma-informed care, visit serenityhealthcarecenter.com or explore our functional medicine platform at venari.com. Survivors seeking support can reach the National Human Trafficking Hotline at 1-888-373-7888. Join our Seen at Last Facebook group, which is a free community where we support women to be seen at last. I’m Dr. Deb. Take care of your body, mind, and spirit. Be well, and we’ll see you on the next episode.The post Episode 260 – How Trauma Passes Through Generations: Epigenetics, Trafficking and Chronic Illness first appeared on Let's Talk Wellness Now.

We are now into Aries season — our first sign of the yearly zodiac. In honor of the astrological new year, we're kicking off a quarterly Element series here on the Plant Path, which we'll do at the equinoxes — in Aries and Libra, and at the solstices — in the signs of Cancer and Capricorn. Today, in honor of Aries and the recent equinox, we'll discuss the first Element: Fire, the spark of life, which governs vitality, transformation, and the movement of energy through people and plants. We'll explore how Fire expresses itself through humans and through plants, offering a deeper lens for understanding constitution, physiology, and plant energetics. Here's what you'll learn: Why the Elements form the foundation of traditional medicine systems worldwide How the Fire Element emerges in alchemy, astrology, and herbalism The role of the Fire Element in human physiology, including the HPA axis, circulation, and vital force Key differences between the three Fire signs: Aries, Leo, and Sagittarius How Fire moves through the body as a coordinated energetic system The core traits of Fire-type constitutions in people How to recognize Fire Element signatures in plants through morphology, taste, and energetics The primary actions of Fire herbs including stimulation, circulation, and immune activation How Fire herbs support (or balance) excess and deficiency patterns in the body Examples of classic Fire Element plants ———————————— CONNECT WITH SAJAH AND WHITNEY ———————————— To get free in depth mini-courses and videos, visit our blog at:  http://www.evolutionaryherbalism.com   Get daily inspiration and plant wisdom on our Facebook and Instagram channels: http://www.facebook.com/EvolutionaryHerbalism https://www.instagram.com/evolutionary_herbalism/   Be sure to subscribe to our YouTube Channel: https://www.youtube.com/channel/UCyP63opAmcpIAQg1M9ShNSQ   Get a free 5-week course when you buy a copy of the book, Evolutionary Herbalism: https://www.evolutionaryherbalism.com/evolutionary-herbalism-book/   Shop our herbal products:  https://naturasophiaspagyrics.com/   ———————————— ABOUT THE PLANT PATH ———————————— The Plant Path is a window into the world of herbal medicine. With perspectives gleaned from traditional Western herbalism, Ayurveda, Chinese Medicine, Alchemy, Medical Astrology, and traditional cultures from around the world, The Plant Path provides unique insights, skills and strategies for the practice of true holistic herbalism. From clinical to spiritual perspectives, we don't just focus on what herbs are "good for," but rather who they are as intelligent beings, and how we can work with them to heal us physically and consciously evolve.   ———————————— ABOUT SAJAH ———————————— Sajah Popham is the author of Evolutionary Herbalism and the founder of the School of Evolutionary Herbalism, where he trains herbalists in a holistic system of plant medicine that encompasses clinical Western herbalism, medical astrology, Ayurveda, and spagyric alchemy. His mission is to develop a comprehensive approach that balances the science and spirituality of plant medicine, focusing on using plants to heal and rejuvenate the body, clarify the mind, open the heart, and support the development of the soul. This is only achieved through understanding and working with the chemical, energetic, and spiritual properties of the plants. His teachings embody a heartfelt respect, honor and reverence for the vast intelligence of plants in a way that empowers us to look deeper into the nature of our medicines and ourselves. He lives on a homestead in the foothills of Mt. Baker Washington with his wife Whitney where he teaches, consults clients, and prepares spagyric herbal medicines.    ———————————— WANT TO FEATURE US ON YOUR PODCAST? ———————————— If you'd like to interview Sajah or Whitney to be on your podcast, click here to fill out an interview request form.  

Your gut microbiome controls your brain chemistry, your stress response, your sleep, your metabolism, and your ability to lose weight, and most people have no idea how broken theirs actually is. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Get 20% off your next purchase of OMNi-BiOTiC with code ‘Dave20' at: https://omnibioticlife.com/ In this episode, Host Dave Asprey and microbiome expert Hannah Kleinfeld break down the hidden gut science behind GLP-1 drugs, ADHD, HRV, histamine intolerance, SIBO, and why most probiotics you're taking are probably dead before they even reach your intestines. Hannah Kleinfeld is the co-founder and COO of Omni-Biotic US, a Yale and Harvard graduate, and a certified health coach whose personal battle with Lyme disease drove her deep into functional medicine and microbiome science. Omni-Biotic is the number one probiotic brand in Europe, used in hospital systems alongside antibiotic treatment, and is now bringing that clinical-grade research to the US market. Dave and Hannah go deep on the gut-brain axis, the vagus nerve, and how dysbiosis drives everything from brain fog and poor sleep optimization to inflammation, metabolic dysfunction, and compromised mitochondria. They cover how GLP-1 drugs slow gut transit time and trigger secondary dysbiosis, why most capsule probiotics rehydrate in stomach acid and fail, how short-chain fatty acids like butyrate cross the blood-brain barrier to regulate neuroinflammation, and how your gut bacteria directly control your heart rate variability, hormones, libido, and skin. This is biohacking your biology from the inside out, and it goes far deeper than supplements and fasting. You'll Learn: Why GLP-1 drugs like Ozempic create secondary dysbiosis and what to do about it How gut inflammation suppresses HRV, disrupts sleep, and accelerates aging Why most probiotics rehydrate in stomach acid and never make it to your intestines The gut-brain connection behind ADHD, brain fog, anxiety, and mood disorders How dysbiosis sabotages weight loss by skewing Firmicutes to Bacteroidetes ratios What the vagus nerve has to do with stress resilience and mitochondria health How to support your microbiome through antibiotics, travel, and SIBO recovery The histamine problem hiding inside popular probiotic strains Why the first 1,000 days of a baby's life shape lifelong immunity and HPA axis function How targeted probiotic formulations are changing functional medicine Thank you to our sponsors! Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off todayPre-order Arthur Brook's new book today at themeaningofyourlife.com. You can also see Arthur speak live at the 2026 Beyond Biohacking Conference Fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVEBrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power BundleDave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Hannah Kleinfeld, Omni-Biotic, gut microbiome, probiotics that work, GLP-1 gut damage, Ozempic side effects, secondary dysbiosis, gut brain axis, vagusnerve HRV, SIBO treatment, histamine intolerance probiotics, leaky gut inflammation, butyrate blood brain barrier, ADHD gut connection, probiotic capsules vs powder, antibiotic recovery, gut skin axis, microbiome sleep, Firmicutes Bacteroidetes weight loss, functional medicine gut health Resources: • Get 20% off your next purchase of OMNi-BiOTiC with code ‘Dave20' at: https://omnibioticlife.com/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 - Trailer 01:10 - Intro03:12 - Kids & Gas: Gut Imbalance in Children 06:42 - Pills vs. Powder Probiotics 07:28 - Omnibiotic Overview & Dave's Story 10:44 - Probiotics & Heart Rate Variability14:14 - GLP-1 Drugs & the Microbiome 17:24 - Gut & Sleep Quality 19:13 - Probiotics & SIBO 27:47 - Gut Bacteria & ADHD 29:55 - Gut, Libido & Fertility 36:04 - Gut & Unusual Microbiome Facts 43:22 - Histamine Intolerance & Probiotics 51:58 - Kids' Microbiome vs. Adults' 56:10 - Outro See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.