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Matt Gruhn, President of the MRAA, returns to GarageCast to discuss the future of marine retail, leadership, and his new book, Anchoring. From evolving customer expectations to data-driven decisions and the nine disciplines every dealer needs to succeed, this conversation is packed with practical insights for marine and powersports professionals ready to lead what's next.UPDATE 2027 is back.Join Garage Composites January 31–February 1 for one of the powersports and marine industry's premier training and networking events.Featuring industry training, 20 Clubs, and opportunities for dealers, manufacturers, vendors, owners, and managers to connect and grow.Bring your team and plan to join us for UPDATE 2027.
In this episode, we speak with Andrea Brand, Chair of the Department of Cell Biology at NYU Grossman School of Medicine and Director of the Regenerative Medicine Institute. We discuss her scientific path from yeast gene regulation to Drosophila neurobiology, and how early interests in DNA and microscopy shaped her career. We talk about the development of the GAL4 system with Norbert Perrimon and how it enabled targeted gene expression in specific tissues and cells. Andrea explains why this approach has remained useful across decades, including its applications in Drosophila and beyond, while noting that no experimental system is perfect and results should be cross-checked with other methods. We also discuss targeted DAM-ID and chromatin DAM-ID, methods developed in her lab to study protein-DNA interactions and chromatin marks in vivo without removing cells from their normal tissue environment. Andrea describes how these tools helped her lab analyze neural stem cells in their niche and investigate changes in chromatin during quiescence and reactivation. A major theme of the conversation is neural stem cell quiescence. We cover how her lab found that quiescent stem cells can show unexpectedly open chromatin, express neuronal genes, and adopt neuron-like features, including long projections and interactions with neurons. We also discuss the link to metabolism, including feeding signals, the fat body, blood-brain barrier glia, insulin-like peptides, and TGF-beta signaling. Finally, we talk about Andrea's recent move toward human brain organoids and the goal of connecting model organism work to human biology and patient data. We discuss ongoing work on quiescent cells, TRIB family genes, and cancer–neuron interactions, as well as the need to better distinguish quiescence from senescence in vivo. References Brand, A. H., & Perrimon, N. (1993). Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development (Cambridge, England), 118(2), 401–415. https://doi.org/10.1242/dev.118.2.401 Southall, T. D., Gold, K. S., Egger, B., Davidson, C. M., Caygill, E. E., Marshall, O. J., & Brand, A. H. (2013). Cell-type-specific profiling of gene expression and chromatin binding without cell isolation: assaying RNA Pol II occupancy in neural stem cells. Developmental cell, 26(1), 101–112. https://doi.org/10.1016/j.devcel.2013.05.020 Tang, J. L. Y., Hakes, A. E., Krautz, R., Suzuki, T., Contreras, E. G., Fox, P. M., & Brand, A. H. (2022). NanoDam identifies Homeobrain (ARX) and Scarecrow (NKX2.1) as conserved temporal factors in the Drosophila central brain and visual system. Developmental cell, 57(9), 1193–1207.e7. https://doi.org/10.1016/j.devcel.2022.04.008 Cheetham, S. W., & Brand, A. H. (2018). RNA-DamID reveals cell-type-specific binding of roX RNAs at chromatin-entry sites. Nature structural & molecular biology, 25(1), 109–114. https://doi.org/10.1038/s41594-017-0006-4 Cheetham, S. W., Gruhn, W. H., van den Ameele, J., Krautz, R., Southall, T. D., Kobayashi, T., Surani, M. A., & Brand, A. H. (2018). Targeted DamID reveals differential binding of mammalian pluripotency factors. Development (Cambridge, England), 145(20), dev170209. https://doi.org/10.1242/dev.170209 Related Episodes scDamID, EpiDamID and Lamina Associated Domains (Jop Kind) Characterizing Chromatin at the Nuclear Lamina (Bas van Steensel) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com
How do you trade without ever losing money? This week, Perpetuals Group CEO Patrick Gruhn, LL.M., MBA joins us to discuss UpsideOnly, a platform where users make market predictions while the company takes the trading risk. We also discuss how lessons from FTX helped shape a different approach to retail trading and prediction markets https://www.perpetuals.com … Continue reading Ep 289- Perpetuals CEO Patrick Gruhn
In Memoriam: Beate Gruhn† war langjähriges Mitglied im Freien Deutschen Autorenverband Bayern. Sie schrieb Erzählungen und Gedichte. BEATE GRUHN wurde in Wiesbaden geboren. Aufenthalte in England und den USA. Sie arbeitete als MTA in der Forschung an der Universitätsklinik München. Preis der griechischen Union Soroptimist International Athen mit einer Kurzgeschichte beim Wettbewerb The spirit of the Olympic Games during Ancient Times, the sacred Olympic Truce and its impact on today´s reality. Beate Gruhn veröffentlichte in zahlreichen Literaturzeitschriften und Anthologien. Dazu gehören der Erzählband Zeitfragmente 2006, ein Gedichtband im Eiland Wiesenburg Verlag 2009. „François und andere Erzählungen“ sowie „Der letzte Buchstabe“ sind im Salon Literatur-Verlag erschienen.Es liest Beate Gruhn(Hördauer 28 Minuten)
In Memoriam: Beate Gruhn† war langjähriges Mitglied im Freien Deutschen Autorenverband Bayern. Sie schrieb Erzählungen und Gedichte. BEATE GRUHN wurde in Wiesbaden geboren. Aufenthalte in England und den USA. Sie arbeitete als MTA in der Forschung an der Universitätsklinik München. Preis der griechischen Union Soroptimist International Athen mit einer Kurzgeschichte beim Wettbewerb The spirit of the Olympic Games during Ancient Times, the sacred Olympic Truce and its impact on today´s reality. Beate Gruhn veröffentlichte in zahlreichen Literaturzeitschriften und Anthologien. Dazu gehören der Erzählband Zeitfragmente 2006, ein Gedichtband im Eiland Wiesenburg Verlag 2009. „François und andere Erzählungen“ sowie „Der letzte Buchstabe“ sind im Salon Literatur-Verlag erschienen.Es liest Beate Gruhn(Hördauer 34 Minuten)
Nach dem Abstieg von Rasta Vechta II steht Hendrik Gruhn seit dieser Saison an der Seitenlinie der Artland Dragons. Wie funktioniert die Zusammenarbeit zwischen beiden Standorten im Rahmen der neuen Kooperation? Wie ist es den Dragons gelungen, mit Ben Burnham und Amir Hinton die beiden aktuell besten Scorer der Liga ins Boot zu holen? Hendrik verrät uns, ob er diesen Mega-Impact vorausgesehen hat und wie er das Training steuert, wenn gleich zwei offensive Hochkaräter zur Verfügung stehen. Eine Episode voller exklusiver Insights – und mit der vermutlich höchsten Wortwitz-Dichte der Podcast-Geschichte.Tickets Live-Podcast mit Fabo: https://www.eventbrite.de/e/1981513916465?aff=oddtdtcreator
Carter Lyons '97 of Two Sigma Investments shares his perspective on AI in the investment industry.Blue book examsWatch the 2025 Gruhn lecture featuring Carter Lyons '97Learn more about McKay Price and his researchLLM use case in finance from Two SigmaLearn more about Two Sigma
Real Life | Part 4 | Dave Gruhn
Real Life | Part 1 | Dave Gruhn
Catalyst | Part 3 | Mark Hoffman & Dave Gruhn
Catalyst | Part 2 | Dave Gruhn
Reset | Part 3 | Dave Gruhn
Reset | Part 2 | Dave Gruhn
Flipped | Part 14 | Dave Gruhn
Flipped | Part 13 | Dave Gruhn
Flipped | Part 10 | Dave Gruhn
Flipped | Part 3 | Dave Gruhn
Flipped | Part 1 | Dave Gruhn
Easter Eggs | Part 5 | Dave Gruhn
Easter Eggs | Part 3 | Dave Gruhn
Patrick Gruhn has made a significant impact in the field of faith and technology. He join Pat Ryan for an in-depth discussion on faith, technology and evangelization. Subscribe to the Morning Blend on your favorite podcast platform.Find this show on the free Hail Mary Media App, along with a radio live-stream, prayers, news, and more.Look through past episodes or support this podcast.The Morning Blend is a production of Mater Dei Radio in Portland, Oregon.
Unveiled | Part 10 | Dave Gruhn
Unveiled | Part 7 | Dave Gruhn
Unveiled | Part 6 | Dave Gruhn
Unveiled | Part 4 | Dave Gruhn
Unveiled | Part 2 | Dave Gruhn
I went to Roberto Venn School of Luthiery in 1997. Worked at Vince's Backstage music in Lafayette, La. until 2000. I then moved to the Hamptons, which was a mistake for my career. Ended up working other jobs, as well as repair to pay the bills. 2002 Moved to Nashville and ended up working for a company in Franklin that did factory refurbishments and Warranty repairs. I also had my own small shop and did a little touring with small bands. In December 06 I started working for Gruhn and was there till Aug. 2024. Even working for shops I've always had my own shop to do personal customer repairs. At Gruhn, I was a Repairman and Appraiser. I was tasked with going through the Electric instruments to inspect for originality. One of the repairs I did a lot of was Pickup rewinds. I've been rewinding pickups since 1999. Although I got most of my experience at Gruhn. I started building Pickups around 05. I have built and rewound pickups for a lot of folks In Nashville. Mostly players. Issac Brock of Modest Mouse uses my pickups in the Wicks guitars he uses in the studio and on tour. One of the Tele's Jack White uses in the Studio has one of my rewinds in the bridge position.I've worked for Songwriters like Kent Blazy (Garth Brooks, Patti Loveless, Chris Young), and producers like Mickey Jack Cones (Carrie Underwood, George Strait, etc.). I've worked with Jack White doing repairs, customization, and Tour Support since 2010. The cover of one of his 45's features him, one of the guitars I customized, and the Muppets. Through Gruhn I worked on instruments owned by a myriad of stars. I also curate the Private collection of the CEO of Gibson, Cesar Gueikian. As well as help take care of instruments at several Studios.IG - i_got_broke_guitarsSome Notable Instruments:Jack's Blue Tele Used on His first Solo Tours- I customizedJack's Blue Triple Jet- I did the finishJack's Black Tele- CustomizedThe Kay- too many repairs to list, this one gets thrown aroundThe Army/Navy-too many repairs over the yearsI've kept a lot of his instruments on the road.Neil Young's Old Black- refrettedChuck Panozzo (Styx)- Replaced the truss rods and repaired the neck on the Rickenbacker he used in the 70'sCaitlin Rose and Band, Butch Walker, Tommy Shaw- Styx, Will Evankovich- Styx, Brian Bell- WeezerAt Gruhn Worked on instruments played by:Clapton, Billy Gibbons, Billy Corgan, Clint Black, Tom Kiefer- Cinerella, Mick Mars, Phil Everly, Ira Louvin, John Denver, Mike Farris, Nancy Wilson, Tex Ritter , Mel Bay, the list goes on.........I once almost killed Loretta Lynn by knockin' her off the back of the stage. Once talked with a man in a turban, beard, and English Accent for 20 minutes, and never knew it was Cat Stevens. Many early prototype guitars and early examples of Holy Grail guitars have been through my hands:First serial numbered and sold StratocasterProto Flying V, Stratocaster, Gretsch Duo Jet, Firebird, Rosewood Telecaster (yes, that predates George Harrison's), Les Paul Junior Prototype, Multiple one-off Chet Atkins Gretch Models, etc."Still on the Run" - https://www.fbrmusic.com/IG - treymitchellphotography IG - feeding_the_senses_unsensoredFB - facebook.com/profile.php?id=100074368084848Threads - www.threads.net/@treymitchellphotographyGuest Suggestions/Spons
Final episode
Living Advent | Part 4 | Dave Gruhn
Living Advent | Part 3 | Dave Gruhn
Radical | Part 3 | Dave Gruhn
Radical | Part 1 | Dave Gruhn
In The Wilderness | Part 4 | Dave Gruhn