Cup, dish or stone with miraculous powers, important motif in Arthurian literature
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In this third episode of the Holy Grail of Investing Podcast, Tony Robbins and Christopher Zook sit down with Jason Ballard, founder and CEO of ICON. ICON is one of the most disruptive technology companies of the past decade as they redefine our understanding or home construction using 3D printing, robotics, software and advanced materials. Jason's vision stretches from solving the world's housing crises to partnering with NASA to build structures on the Moon! Jason's personal story is one of fearless faith, personal trials and perfecting the art of “joyful grit.”
This week EPA administrator Lee Zeldin began the process of negating the 2009 “Endangerment Finding” that was, as President Obama called it, the ‘Holy Grail of Climate Change Regulation.' This was where the idea that the very byproduct of Human existence, Carbon Dioxide, could be regulated as a pollutant. So, here in Viginia we have the Virginia Clean Economy Act that was passed in 2020 by the Democrat-majority General Assembly and signed into law by Governor Ralph Northam. If you have heard about “California-ing Virginia,” this is the act that did that. Connecting Virginia's environmental regulations to California's including getting to “net zero” carbon emissions by 2030. This law also put a stop to new electric generating facilities being built to replace retiring ones despite the demand skyrocketing. What does the EPA's action mean for this law? Can it be repealed? Overturned in court? We sit down with analyst for the Thomas Jefferson Institute Steve Haner to find out. Learn more about your ad choices. Visit megaphone.fm/adchoices
The deconstruction of the Deep State Matrix begins as Trump finally gets his hands on the Holy Grail of evidence. Tulsi says the CIA's Project Mockingbird is still up and running? Why were child sex offenders flocking to America under Biden? (Please subscribe & share.) Sources: https://www.breitbart.com/politics/2025/07/29/poll-majority-oppose-local-authorities-in-sanctuary-cities-blocking-criminal-deportations/ https://nypost.com/2025/07/27/opinion/the-great-northeast-exodus-how-high-taxes-are-driving-away-billions/ https://www.wsj.com/business/ford-coors-gay-rights-index-dei-04c4ff94?reflink=desktopwebshare_permalink https://thehill.com/policy/international/5423711-trump-eu-trade-deal-tariffs-france/ https://nypost.com/2025/07/31/us-news/eric-adams-vetoes-city-councils-bid-to-decriminalize-illegal-vending-in-nyc/ https://www.foxnews.com/us/ice-arrests-over-200-illegal-alien-child-sex-offenders-houston-area-past-6-months?intcmp=tw_fnc&taid=6887a59e58ae3600011d3403&utm_campaign=trueanthem&utm_medium=social&utm_source=twitter https://newsbusters.org/blogs/nb/jorge-bonilla/2025/07/30/predictable-legacy-newscasts-omitted-fbi-russia-hoax-burn-bag https://newsbusters.org/blogs/nb/curtis-houck/2025/07/29/buried-nets-give-1000-times-more-coverage-russia-probe-gabbard https://libertywingspan.com/52879/uncategorized/operation-mockingbird/ https://redstate.com/smoosieq/2025/07/31/new-the-durham-annex-is-out-and-its-a-doozy-n2192305
It can seem in 2025 like everyone in the ad ecosystem is chasing after the same Holy Grail: fast, rapidly delivered, personalized content at whatever scale they fancy. With the help of (yes) AI, it seems that dream is closer than ever. But is the business ready for it? Hosted on Acast. See acast.com/privacy for more information.
Willie talks with Jim Moering from the Holy Grail about the restaurant owners response to the violence downtown. Also Governor Mike DeWine weighs in. Finally Re Adam Bird explains why things need to change starting at the ballot box.
AlabamaSen. Britt says Dems spreading misinformation about GOP Medicaid changes2 state lawmakers pre file bill to offer death penalty in cases of child rapeState lawmaker files bill to prevent vaccine mandates by businesses in ALFarmPAC endorses Young Boozer in his re-election bid for state treasurerAn illegal alien on immigration hold, along with drug and stabbing charges9 dogs have been euthanized in Chilton county for attack that killed boyNationalNYC office shooting has 5 people dead including gunman, Shane TamuraUS AG Bondi files judicial conduct complain against Judge James BoasbergICE agents arrest Jamaican man working as police officer in state of MaineHouston ICE agents arrest over 200 illegal aliens who are child sex offendersUCLA agrees to $6.13M settlement for allowing antisemitic encampmentsEPA Director to end the "Holy Grail" of climate change: emissions regulationsHHS secretary makes big point on the increase in autism rates in USDouglass Mackey, "The Meme Guy" taking steps to countersue US government
From a gritty warlord in a chaotic Britain to a shining king in a legendary castle, the story of King Arthur has captivated the world for over 1,000 years. But how much of it is true? In this episode of English Plus, we pull the sword from the stone to separate the man from the myth. We're on a quest to answer the big questions: Who was the real historical figure that might have inspired the legend? How did French romance add Lancelot and the famous love triangle to the story? What is the true meaning of the Round Table, the Holy Grail, and the enigmatic wizard Merlin? Why does the dream of Camelot still hold such power over us today? This episode is also your key to more sophisticated English. We break down 10 essential words and phrases like "archetype," "chivalry," "anachronism," and "utopian" to elevate your vocabulary. Plus, a special speaking lesson on using narrative structure will help you tell more compelling stories in your own life. Join us for a journey into the heart of history, myth, and legend. To unlock full access to all our episodes, consider becoming a premium subscriber on Apple Podcasts or Patreon. And don't forget to visit englishpluspodcast.com for even more content, including articles, in-depth studies, and our brand-new audio series and courses now available in our Patreon Shop!
Willie talks with Jim Moering from the Holy Grail about the restaurant owners response to the violence downtown. Also Governor Mike DeWine weighs in. Finally Re Adam Bird explains why things need to change starting at the ballot box.
Willie talks with Jim Moering from the Holy Grail about the restaurant owners response to the violence downtown. Also Governor Mike DeWine weighs in. Finally Re Adam Bird explains why things need to change starting at the ballot box.
The 3M Open was a birdie fire sale as everyone went low, low, low. The ISPS Handa Senior Open was another major victory for Padraig Harrington, who is making a case for Player of the Year. The ISPS Handa Women's Scottish Open featured a win for the newly turned pro Lottia Woad, who is also now the favorite for this week's Open Championship. Past guest Mia Hammond, known for dropping out of school at 16 to go pro, got her first win this week on the Epson Tour. Alex got to play one of the Holy Grails of golf last week, Payne's Valley at Big Cedar Lodge. He shares what made it so great, and where it ranks in his list of amazing courses. In Tuned In, Michael and Alex share their reviews of Happy Gilmore 2, and Michael was not a fan. This week's guest is Megan Johnston, returning to the podcast as Alex chats with her from Big Cedar Lodge. The golf instructor, named as one of the country's best by Golf Digest and the LPGA, shares what drew her to Big Cedar Lodge and what makes the Ozarks such an amazing part of the country. The NFL Preseason is now upon us, as football games start up on Thursday. So Alex is, as always, overwhelmed with excitement. As the guys #AlwaysEndWithFood, Alex shares his excitement for all the pizza he'll be eating in the Chicago area this next week, and Michael shares a glowing review of Eden Supper Club in Savannah. Learn more about your ad choices. Visit megaphone.fm/adchoices
Okay... look. It's embarrassing, but writers are good storytellers, they're not always good at spelling. That's editors. So, come clean, writers: what is a word you cannot spell?Featuring, from Breakwater Books Ltd.:Rebecca Rose, President and PublisherAinsley Hawthorn, Land of Many ShoresKerri Cull, author of Rock Paper Sex: Trigger WarningMichelle Porter, author of Approaching FireOlivia Robinson, author of Blue Moth MotelTzu-Hao Hsu, contributor to Us, NowTrudy Morgan-Cole, author of The Cupids TrilogyFrom Anstruther Press: Daze Jefferies, author of Water/WeptFrom Iceberg Publishing:Kenneth Tam, author of The Champions seriesFrom Flanker Press Ltd.:Tom Moore, author of The Sign on My Father's HouseFrom Image Comics:Paul Tucker, artist of StringerFrom Independent Authors:Katie Berry, the author of Claw!Originally broadcast on July 28, 2025 on CHMR 93.5 FM in St. John's, and on other great stations across the country. Check out As Loved Our Fathers, the latest book from Write Project host Matthew LeDrew: https://amzn.to/3HB7BABIt's a hunt for the Holy Grail taken on by an American Anthropologist and a Newfoundland History professor that unveils hidden secrets within Newfoundland history! Support the showProduced and recorded at CHMR 93.5 FM in St. John's, Newfoundland. Listen on CHMR online at http://www.chmr.ca/This program is sponsored by:Engen Books: Checkout Engen titles at http://www.engenbooks.com/Or sign up for their newsletters at: The Write Project signup for FREE book: http://eepurl.com/c8W9OTEngen Horror Society Signup for FREE book: http://eepurl.com/c8YemrFantasy Files signup for FREE book: http://eepurl.com/c8X4zLEngen's Science-Fiction Newsletter for FREE book: http://eepurl.com/ir5JmgThis recording copyright © 2024 Matthew LeDrew
Join Chad Brendel and David Simone for the BCJ Podcast, presented by Holy Grail live from the Cincy Light Studios! This week they bring on BCJ's own Keegan Nickoson and start the show off discussing a full camp preview as the team prepares to invade Camp Higher Ground next week. The follow that up with a long discussion of preseason spotlights, focusing on players that may not necessarily be on your radar yet. Stop by Holy Grail for great food, drinks, and ice-cold Cincy Light—50 cents from every purchase supports UC athletes! Join the conversation live every Wednesday night at 8pm on the Bearcat Journal Twitch and YouTube channels, and don't forget to like and subscribe while you're there! Turtle's Brew Time Stamps 0:00 - 58:00 Camp Preview 58:00 - 1:52:02 Preseason Spotlights
Chris Edwards joined us for LFS1 representing his new band Wheelhouse Deluxe! He claimed that he was still waking up but after that charged cover of Holy Grail by Hunters & Collectors, we’re all wide awake now! Flaming KnightsSee omnystudio.com/listener for privacy information.
The Jesus bloodline refers to the proposition that a lineal sequence of the historical Jesus has persisted, possibly to the present time. Although absent from the Gospels or historical records, the concept of Jesus having descendants has gained a presence in the public imagination, as seen with Holy Blood, Holy Grail a book by Michael Baigent, Richard Leigh, and Henry Lincoln and Dan Brown's 2003 best-selling novel The Da Vinci Code. These claimed Jesus's bloodlines are distinct from the biblical genealogy of Jesus, which concerns the ancestors of Jesus, and from the alleged Brothers of Jesus and other kin of Jesus, known as the Desposyni. In the final chapter of Joel's intricate look at the supposed bloodlines of Jesus, Joel explores the Lost Tomb of Jesus and if there is any validity to the claims of the documentary. He shines a light on Simcha Jacovici's claims that the ossuaries found in the Talpiot Tomb are of Jesus and His family. He also looks at the idea that Jesus is of an alien race which are the creators of the Rh-Negative bloodline. Lastly, Joel speculates on where the Rex Deus genealogies actually come from and what it means for our possible future. The Meadow Project Film Tickets: https://www.moment.co/themeadowproject Free The Rabbits Merch: https://freetherabbits.myshopify.com Buy Me A Coffee: Donate Website: https://linktr.ee/joelthomasmedia Follow: Instagram | X | Facebook Watch: YouTube | Rumble Music: YouTube | Spotify | Apple Music Films: merkelfilms.com Email: freetherabbitspodcast@gmail.com Distributed by: merkel.media Produced by: @jack_theproducer INTRO MUSIC Joel Thomas - Free The Rabbits YouTube | Apple Music | Spotify OUTRO MUSIC Joel Thomas - Imposter YouTube | Apple Music | Spotify
1989 was what some might call a good year for movies. The top-grossing films could easily be mistaken for anyone's favorite 80s movies list: Batman, Lethal Weapon 2, Rain Man, Ghostbusters II. You might even consider including Tango & Cash. But only one 1989 release brought back the iconic bullwhip and fedora.Indiana Jones returned to the big screen in a blockbuster adventure full of humor, heart, and incredible stunts. Set in 1938, our hero embarks on a mission to rescue his father, a medievalist who has disappeared while searching for the Holy Grail. Following clues in Henry Sr.'s cherished notebook, Indy travels to Europe, reuniting with old allies while battling new Nazi enemies.So, dust off your fedora, crack the bullwhip, and take a leap of faith with Tim Williams and guest co-hosts, Gerry D, Nicholas Pepin, and Chad Sheppard as they discuss “Indiana Jones and the Last Crusade” on this episode of the 80s Flick Flashback Podcast!Here are some additional behind-the-scenes trivia we were unable to cover in this episode:When Henry expresses surprise that Indy can fly a plane, Indiana responds with "Fly, yes. Land, no." This references his crashing a plane in "Indiana Jones and the Temple of Doom" (1984).Henry Sr. and Jr. point out that in Latin, Jehovah starts with an I, not a J. This is accurate, especially considering that the knight who recovered the Grail did so during the First Crusade. The First Crusade ended in 1099. During the Roman Empire, J was just a variation of an I, which is why their lowercase forms, i and j, look similar. The original pronunciation was very much like an I or Y. Its use as a soft 'g' sound did not appear before the 15th century.Sources:Wikipedia, IMDB, BoxOfficeMojohttps://www.shortlist.com/news/15-things-you-probably-didnt-know-about-indiana-jones-and-the-last-crusadeSome sections were composed by ChatGPTWe'd love to hear your thoughts on our podcast! You can share your feedback with us via email or social media.Website - https://www.80sflickflashback.com/TeePublic Store - https://www.teepublic.com/user/eighties-flick-flashbackBuy Me A Coffee - https://buymeacoffee.com/80sflickfbFacebook - https://www.facebook.com/80sflickflashbackpodcastInstagram - https://www.instagram.com/80sflickflashback/TikTok - https://www.tiktok.com/@80sflickflashbackEmail - Info@80sFlickFlashback.com
Chad Brendel and David Simone discuss the week that was Cincinnati Bearcats live from the Cincy Light Studios. They kick the show off with special guest Offensive Line Coach Nic Cardwell, before moving to football notes and loose ends. They wrap up the show with a discussion on the men's basketball media availability today, and a rant by David about Home Run Hitter Mardy Gilyard. Join the conversation live every Wednesday night at 8pm on the Bearcat Journal Twitch and YouTube channels, and don't forget to like and subscribe while you're there! Turtle's Brew Time Stamps 0:00 - 49:00 Offensive Line Coach Nic Cardwell 49:00 - 1:15:00 Football Notes and Loose Ends 1:15:00 - 1:37:16 Men's Basketball Media Availability
Meinen Fachleute eine bedeutende Beobachtung gemacht zu haben, sprechen sie manchmal vom "Heiligen Gral", den sie aufgespürt hätten. Ob Schwefelverbindungen, kosmische Hintergrundstrahlung oder vermisster Asteroid: der Heilige Gral ist sehr vielfältig! Lorenzen, Dirk www.deutschlandfunk.de, Sternzeit
Send us a textMike Munger explores how Monty Python brilliantly illustrated transaction cost economics through their legendary comedy sketches. The British comedy troupe's most famous routines provide perfect, hilarious examples of the frictions that make economic interactions costly and complicated in the real world.• Three definitions of transaction costs from Ronald Coase, Douglas North, and Oliver Williamson• The Dead Parrot sketch as an illustration of ex-post recontracting problems and contract enforcement• Ministry of Silly Walks demonstrating how inefficient institutions persist due to high reform costs• The Argument Clinic depicting problems with contract scope and definition• Monty Python and the Holy Grail showing barriers to entry and communication costs• Spanish Inquisition sketch revealing coordination failuresThe five MP sketches mentioned here:Dead Parrot Sketch: https://youtu.be/4vuW6tQ0218?si=hHfu07sgQeCgxUxx Ministry of Silly Walks: https://youtu.be/iV2ViNJFZC8?si=U5QxzDeYXeT3UhIq Argument Clinic: https://youtu.be/uLlv_aZjHXc?si=aU14dFjwnJeDvRf7 Holy Grail—Anarcho-Syndicalist Peasant: https://youtu.be/_EMZ1u__LUc?si=C9z8e4NAQDRkU8q7 Spanish Inquisition: https://www.youtube.com/watch?v=D5Df191WJ3o Letter: Swiss Air's efficient window-seat-first boarding policyBook'o'da'week: To Overthrow the World: The Rise and Fall and Rise of Communism, by Sean McMeekinNext episode releases July 22nd, beginning the co-produced series on Adam Smith's "Wealth of Nations" with an overview of the Scottish Enlightenment.If you have questions or comments, or want to suggest a future topic, email the show at taitc.email@gmail.com ! You can follow Mike Munger on Twitter at @mungowitz
The Jesus bloodline refers to the proposition that a lineal sequence of the historical Jesus has persisted, possibly to the present time. Although absent from the Gospels or historical records, the concept of Jesus having descendants has gained a presence in the public imagination, as seen with Holy Blood, Holy Grail a book by Michael Baigent, Richard Leigh, and Henry Lincoln and Dan Brown's 2003 best-selling novel The Da Vinci Code. These claimed Jesus's bloodlines are distinct from the biblical genealogy of Jesus, which concerns the ancestors of Jesus, and from the alleged Brothers of Jesus and other kin of Jesus, known as the Desposyni. Joel dives even deeper into the supposed hidden bloodlines of Jesus with a look at who Joseph of Arimathea was historically. He sets his focus on the gnostic Essene version of Joseph and the idea he was actually James the Just, brother of Jesus. He then looks at the Tribe of Scota and how it spawned from ancient Egypt into Ireland and Scottland from Israeli descent and possibly intermingling with the Tuatha De Danann. Lastly, Joel walks through the Fisher Kings, the Merovingians, whose rise to the top was swift and seemingly out of nowhere, but how it makes sense considering the represented the most secretive bloodline in the history of the earth. The Meadow Project Film Tickets: https://www.moment.co/themeadowproject Free The Rabbits Merch: https://freetherabbits.myshopify.com Buy Me A Coffee: Donate Website: https://linktr.ee/joelthomasmedia Follow: Instagram | X | Facebook Watch: YouTube | Rumble Music: YouTube | Spotify | Apple Music Films: merkelfilms.com Email: freetherabbitspodcast@gmail.com Distributed by: merkel.media Produced by: @jack_theproducer INTRO MUSIC Joel Thomas - Free The Rabbits YouTube | Apple Music | Spotify OUTRO MUSIC Joel Thomas - Imposter YouTube | Apple Music | Spotify
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Steve is joined again by Pastors Eric and Justin from Sound the Shofar Messianic Ministries. In the first hour, we discuss the myths and legends surrounding the Holy Grail. Find Sound the Shofar Messianic Ministries online: https://www.facebook.com/groups/123168699032724Become a supporter of this podcast: https://www.spreaker.com/podcast/missing-persons-mysteries--5624803/support.
Chad Brendel and David Simone discuss the week that was Cincinnati Bearcats live from the Cincy Light Studios. They begin the show discussing the chatter from some little birdies that had information from hoops practice. They finish the show with a check in from Keegan Nickoson as he attends Big 12 Media Days. Join the conversation live every Wednesday night at 8pm on the Bearcat Journal Twitch and YouTube channels, and don't forget to like and subscribe while you're there! Turtle's Brew Time Stamps 0:00 - 1:00:00 Warblers Are A-Warblin' 1:00:00 - 1:38:05 Big 12 Media Days
Dr. Paul Hanona and Dr. Arturo Loaiza-Bonilla discuss how to safely and smartly integrate AI into the clinical workflow and tap its potential to improve patient-centered care, drug development, and access to clinical trials. TRANSCRIPT Dr. Paul Hanona: Hello, I'm Dr. Paul Hanona, your guest host of the ASCO Daily News Podcast today. I am a medical oncologist as well as a content creator @DoctorDiscover, and I'm delighted to be joined today by Dr. Arturo Loaiza-Bonilla, the chief of hematology and oncology at St. Luke's University Health Network. Dr. Bonilla is also the co-founder and chief medical officer at Massive Bio, an AI-driven platform that matches patients with clinical trials and novel therapies. Dr. Loaiza-Bonilla will share his unique perspective on the potential of artificial intelligence to advance precision oncology, especially through clinical trials and research, and other key advancements in AI that are transforming the oncology field. Our full disclosures are available in the transcript of the episode. Dr. Bonilla, it's great to be speaking with you today. Thanks for being here. Dr. Arturo Loaiza-Bonilla: Oh, thank you so much, Dr. Hanona. Paul, it's always great to have a conversation. Looking forward to a great one today. Dr. Paul Hanona: Absolutely. Let's just jump right into it. Let's talk about the way that we see AI being embedded in our clinical workflow as oncologists. What are some practical ways to use AI? Dr. Arturo Loaiza-Bonilla: To me, responsible AI integration in oncology is one of those that's focused on one principle to me, which is clinical purpose is first, instead of the algorithm or whatever technology we're going to be using. If we look at the best models in the world, they're really irrelevant unless we really solve a real day-to-day challenge, either when we're talking to patients in the clinic or in the infusion chair or making decision support. Currently, what I'm doing the most is focusing on solutions that are saving us time to be more productive and spend more time with our patients. So, for example, we're using ambient AI for appropriate documentation in real time with our patients. We're leveraging certain tools to assess for potential admission or readmission of patients who have certain conditions as well. And it's all about combining the listening of physicians like ourselves who are end users, those who create those algorithms, data scientists, and patient advocates, and even regulators, before they even write any single line of code. I felt that on my own, you know, entrepreneurial aspects, but I think it's an ethos that we should all follow. And I think that AI shouldn't be just bolted on later. We always have to look at workflows and try to look, for example, at clinical trial matching, which is something I'm very passionate about. We need to make sure that first, it's easier to access for patients, that oncologists like myself can go into the interface and be able to pull the data in real time when you really need it, and you don't get all this fatigue alerts. To me, that's the responsible way of doing so. Those are like the opportunities, right? So, the challenge is how we can make this happen in a meaningful way – we're just not reacting to like a black box suggestion or something that we have no idea why it came up to be. So, in terms of success – and I can tell you probably two stories of things that we know we're seeing successful – we all work closely with radiation oncologists, right? So, there are now these tools, for example, of automated contouring in radiation oncology, and some of these solutions were brought up in different meetings, including the last ASCO meeting. But overall, we know that transformer-based segmentation tools; transformer is just the specific architecture of the machine learning algorithm that has been able to dramatically reduce the time for colleagues to spend allotting targets for radiation oncology. So, comparing the target versus the normal tissue, which sometimes it takes many hours, now we can optimize things over 60%, sometimes even in minutes. So, this is not just responsible, but it's also an efficiency win, it's a precision win, and we're using it to adapt even mid-course in response to tumor shrinkage. Another success that I think is relevant is, for example, on the clinical trial matching side. We've been working on that and, you know, I don't want to preach to the choir here, but having the ability for us to structure data in real time using these tools, being able to extract information on biomarkers, and then show that multi-agentic AI is superior to what we call zero-shot or just throwing it into ChatGPT or any other algorithm, but using the same tools but just fine-tuned to the point that we can be very efficient and actually reliable to the level of almost like a research coordinator, is not just theory. Now, it can change lives because we can get patients enrolled in clinical trials and be activated in different places wherever the patient may be. I know it's like a long answer on that, but, you know, as we talk about responsible AI, that's important. And in terms of what keeps me up at night on this: data drift and biases, right? So, imaging protocols, all these things change, the lab switch between different vendors, or a patient has issues with new emerging data points. And health systems serve vastly different populations. So, if our models are trained in one context and deployed in another, then the output can be really inaccurate. So, the idea is to become a collaborative approach where we can use federated learning and patient-centricity so we can be much more efficient in developing those models that account for all the populations, and any retraining that is used based on data can be diverse enough that it represents all of us and we can be treated in a very good, appropriate way. So, if a clinician doesn't understand why a recommendation is made, as you probably know, you probably don't trust it, and we shouldn't expect them to. So, I think this is the next wave of the future. We need to make sure that we account for all those things. Dr. Paul Hanona: Absolutely. And even the part about the clinical trials, I want to dive a little bit more into in a few questions. I just kind of wanted to make a quick comment. Like you said, some of the prevalent things that I see are the ambient scribes. It seems like that's really taken off in the last year, and it seems like it's improving at a pretty dramatic speed as well. I wonder how quickly that'll get adopted by the majority of physicians or practitioners in general throughout the country. And you also mentioned things with AI tools regarding helping regulators move things quicker, even the radiation oncologist, helping them in their workflow with contouring and what else they might have to do. And again, the clinical trials thing will be quite interesting to get into. The first question I had subsequent to that is just more so when you have large datasets. And this pertains to two things: the paper that you published recently regarding different ways to use AI in the space of oncology referred to drug development, the way that we look at how we design drugs, specifically anticancer drugs, is pretty cumbersome. The steps that you have to take to design something, to make sure that one chemical will fit into the right chemical or the structure of the molecule, that takes a lot of time to tinker with. What are your thoughts on AI tools to help accelerate drug development? Dr. Arturo Loaiza-Bonilla: Yes, that's the Holy Grail and something that I feel we should dedicate as much time and effort as possible because it relies on multimodality. It cannot be solved by just looking at patient histories. It cannot be solved by just looking at the tissue alone. It's combining all these different datasets and being able to understand the microenvironment, the patient condition and prior treatments, and how dynamic changes that we do through interventions and also exposome – the things that happen outside of the patient's own control – can be leveraged to determine like what's the best next step in terms of drugs. So, the ones that we heard the news the most is, for example, the Nobel Prize-winning [for Chemistry awarded to Demis Hassabis and John Jumper for] AlphaFold, an AI system that predicts protein structures right? So, we solved this very interesting concept of protein folding where, in the past, it would take the history of the known universe, basically – what's called the Levinthal's paradox – to be able to just predict on amino acid structure alone or the sequence alone, the way that three-dimensionally the proteins will fold. So, with that problem being solved and the Nobel Prize being won, the next step is, “Okay, now we know how this protein is there and just by sequence, how can we really understand any new drug that can be used as a candidate and leverage all the data that has been done for many years of testing against a specific protein or a specific gene or knockouts and what not?” So, this is the future of oncology and where we're probably seeing a lot of investments on that. The key challenge here is mostly working on the side of not just looking at pathology, but leveraging this digital pathology with whole slide imaging and identifying the microenvironment of that specific tissue. There's a number of efforts currently being done. One isn't just H&E, like hematoxylin and eosin, slides alone, but with whole imaging, now we can use expression profiles, spatial transcriptomics, and gene whole exome sequencing in the same space and use this transformer technology in a multimodality approach that we know already the slide or the pathology, but can we use that to understand, like, if I knock out this gene, how is the microenvironment going to change to see if an immunotherapy may work better, right? If we can make a microenvironment more reactive towards a cytotoxic T cell profile, for example. So, that is the way where we're really seeing the field moving forward, using multimodality for drug discovery. So, the FDA now seems to be very eager to support those initiatives, so that's of course welcome. And now the key thing is the investment to do this in a meaningful way so we can see those candidates that we're seeing from different companies now being leveraged for rare disease, for things that are going to be almost impossible to collect enough data, and make it efficient by using these algorithms that sometimes, just with multiple masking – basically, what they do is they mask all the features and force the algorithm to find solutions based on the specific inputs or prompts we're doing. So, I'm very excited about that, and I think we're going to be seeing that in the future. Dr. Paul Hanona: So, essentially, in a nutshell, we're saying we have the cancer, which is maybe a dandelion in a field of grass, and we want to see the grass that's surrounding the dandelion, which is the pathology slides. The problem is, to the human eye, it's almost impossible to look at every single piece of grass that's surrounding the dandelion. And so, with tools like AI, we can greatly accelerate our study of the microenvironment or the grass that's surrounding the dandelion and better tailor therapy, come up with therapy. Otherwise, like you said, to truly generate a drug, this would take years and years. We just don't have the throughput to get to answers like that unless we have something like AI to help us. Dr. Arturo Loaiza-Bonilla: Correct. Dr. Paul Hanona: And then, clinical trials. Now, this is an interesting conversation because if you ever look up our national guidelines as oncologists, there's always a mention of, if treatment fails, consider clinical trials. Or in the really aggressive cancers, sometimes you might just start out with clinical trials. You don't even give the standard first-line therapy because of how ineffective it is. There are a few issues with clinical trials that people might not be aware of, but the fact that the majority of patients who should be on clinical trials are never given the chance to be on clinical trials, whether that's because of proximity, right, they might live somewhere that's far from the institution, or for whatever reason, they don't qualify for the clinical trial, they don't meet the strict inclusion criteria. But a reason you mentioned early on is that it's simply impossible for someone to be aware of every single clinical trial that's out there. And then even if you are aware of those clinical trials, to actually find the sites and put in the time could take hours. And so, how is AI going to revolutionize that? Because in my mind, it's not that we're inventing a new tool. Clinical trials have always been available. We just can't access them. So, if we have a tool that helps with access, wouldn't that be huge? Dr. Arturo Loaiza-Bonilla: Correct. And that has been one of my passions. And for those who know me and follow me and we've spoke about it in different settings, that's something that I think we can solve. This other paradox, which is the clinical trial enrollment paradox, right? We have tens of thousands of clinical trials available with millions of patients eager to learn about trials, but we don't enroll enough and many trials close to accrual because of lack of enrollment. It is completely paradoxical and it's because of that misalignment because patients don't know where to go for trials and sites don't know what patients they can help because they haven't reached their doors yet. So, the solution has to be patient-centric, right? We have to put the patient at the center of the equation. And that was precisely what we had been discussing during the ASCO meeting. There was an ASCO Education Session where we talked about digital prescreening hubs, where we, in a patient-centric manner, the same way we look for Uber, Instacart, any solution that you may think of that you want something that can be leveraged in real time, we can use these real-world data streams from the patient directly, from hospitals, from pathology labs, from genomics companies, to continuously screen patients who can match to the inclusion/exclusion criteria of unique trials. So, when the patient walks into the clinic, the system already knows if there's a trial and alerts the site proactively. The patient can actually also do decentralization. So, there's a number of decentralized clinical trial solutions that are using what I call the “click and mortar” approach, which is basically the patient is checking digitally and then goes to the site to activate. We can also have the click and mortar in the bidirectional way where the patient is engaged in person and then you give the solution like the ones that are being offered on things that we're doing at Massive Bio and beyond, which is having the patient to access all that information and then they make decisions and enroll when the time is right. As I mentioned earlier, there is this concept drift where clinical trials open and close, the patient line of therapy changes, new approvals come in and out, and sites may not be available at a given time but may be later. So, having that real-time alerts using tools that are able already to extract data from summarization that we already have in different settings and doing this natural language ingestion, we can not only solve this issue with manual chart review, which is extremely cumbersome and takes forever and takes to a lot of one-time assessments with very high screen failures, to a real-time dynamic approach where the patient, as they get closer to that eligibility criteria, they get engaged. And those tools can be built to activate trials, audit trials, and make them better and accessible to patients. And something that we know is, for example, 91%-plus of Americans live close to either a pharmacy or an imaging center. So, imagine that we can potentially activate certain of those trials in those locations. So, there's a number of pharmacies, special pharmacies, Walgreens, and sometimes CVS trying to do some of those efforts. So, I think the sky's the limit in terms of us working together. And we've been talking with corporate groups, they're all interested in those efforts as well, to getting patients digitally enabled and then activate the same way we activate the NCTN network of the corporate groups, that are almost just-in-time. You can activate a trial the patient is eligible for and we get all these breakthroughs from the NIH and NCI, just activate it in my site within a week or so, as long as we have the understanding of the protocol. So, using clinical trial matching in a digitally enabled way and then activate in that same fashion, but not only for NCTN studies, but all the studies that we have available will be the key of the future through those prescreening hubs. So, I think now we're at this very important time where collaboration is the important part and having this silo-breaking approach with interoperability where we can leverage data from any data source and from any electronic medical records and whatnot is going to be essential for us to move forward because now we have the tools to do so with our phones, with our interests, and with the multiple clinical trials that are coming into the pipelines. Dr. Paul Hanona: I just want to point out that the way you described the process involves several variables that practitioners often don't think about. We don't realize the 15 steps that are happening in the background. But just as a clarifier, how much time is it taking now to get one patient enrolled on a clinical trial? Is it on the order of maybe 5 to 10 hours for one patient by the time the manual chart review happens, by the time the matching happens, the calls go out, the sign-up, all this? And how much time do you think a tool that could match those trials quicker and get you enrolled quicker could save? Would it be maybe an hour instead of 15 hours? What's your thought process on that? Dr. Arturo Loaiza-Bonilla: Yeah, exactly. So one is the matching, the other one is the enrollment, which, as you mentioned, is very important. So, it can take, from, as you said, probably between 4 days to sometimes 30 days. Sometimes that's how long it takes for all the things to be parsed out in terms of logistics and things that could be done now agentically. So, we can use agents to solve those different steps that may take multiple individuals. We can just do it as a supply chain approach where all those different steps can be done by a single agent in a simultaneous fashion and then we can get things much faster. With an AI-based solution using these frontier models and multi-agentic AI – and we presented some of this data in ASCO as well – you can do 5,000 patients in an hour, right? So, just enrolling is going to be between an hour and maximum enrollment, it could be 7 days for those 5,000 patients if it was done at scale in a multi-level approach where we have all the trials available. Dr. Paul Hanona: No, definitely a very exciting aspect of our future as oncologists. It's one thing to have really neat, novel mechanisms of treatment, but what good is it if we can't actually get it to people who need it? I'm very much looking for the future of that. One of the last questions I want to ask you is another prevalent way that people use AI is just simply looking up questions, right? So, traditionally, the workflow for oncologists is maybe going on national guidelines and looking up the stage of the cancer and seeing what treatments are available and then referencing the papers and looking at who was included, who wasn't included, the side effects to be aware of, and sort of coming up with a decision as to how to treat a cancer patient. But now, just in the last few years, we've had several tools become available that make getting questions easier, make getting answers easier, whether that's something like OpenAI's tools or Perplexity or Doximity or OpenEvidence or even ASCO has a Guidelines Assistant as well that is drawing from their own guidelines as to how to treat different cancers. Do you see these replacing traditional sources? Do you see them saving us a lot more time so that we can be more productive in clinic? What do you think is the role that they're going to play with patient care? Dr. Arturo Loaiza-Bonilla: Such a relevant question, particularly at this time, because these AI-enabled query tools, they're coming left and right and becoming increasingly common in our daily workflows and things that we're doing. So, traditionally, when we go and we look for national guidelines, we try to understand the context ourselves and then we make treatment decisions accordingly. But that is a lot of a process that now AI is helping us to solve. So, at face value, it seems like an efficiency win, but in many cases, I personally evaluate platforms as the chief of hem/onc at St. Luke's and also having led the digital engagement things through Massive Bio and trying to put things together, I can tell you this: not all tools are created equal. In cancer care, each data point can mean the difference between cure and progression, so we cannot really take a lot of shortcuts in this case or have unverified output. So, the tools are helpful, but it has to be grounded in truth, in trusted data sources, and they need to be continuously updated with, like, ASCO and NCCN and others. So, the reason why the ASCO Guidelines Assistant, for instance, works is because it builds on all these recommendations, is assessed by end users like ourselves. So, that kind of verification is critical, right? We're entering a phase where even the source material may be AI-generated. So, the role of human expert validation is really actually more important, not less important. You know, generalist LLMs, even when fine-tuned, they may not be enough. You can pull a few API calls from PubMed, etc., but what we need now is specialized, context-aware, agentic tools that can interpret multimodal and real-time clinical inputs. So, something that we are continuing to check on and very relevant to have entities and bodies like ASCO looking into this so they can help us to be really efficient and really help our patients. Dr. Paul Hanona: Dr. Bonilla, what do you want to leave the listener with in terms of the future direction of AI, things that we should be cautious about, and things that we should be optimistic about? Dr. Arturo Loaiza-Bonilla: Looking 5 years ahead, I think there's enormous promise. As you know, I'm an AI enthusiast, but always, there's a few priorities that I think – 3 of them, I think – we need to tackle head-on. First is algorithmic equity. So, most AI tools today are trained on data from academic medical centers but not necessarily from community practices or underrepresented populations, particularly when you're looking at radiology, pathology, and what not. So, those blind spots, they need to be filled, and we can eliminate a lot of disparities in cancer care. So, those frameworks to incentivize while keeping the data sharing using federated models and things that we can optimize is key. The second one is the governance on the lifecycle. So, you know, AI is not really static. So, unlike a drug that is approved and it just, you know, works always, AI changes. So, we need to make sure that we have tools that are able to retrain and recall when things degrade or models drift. So, we need to use up-to-date AI for clinical practice, so we are going to be in constant revalidation and make it really easy to do. And lastly, the human-AI interface. You know, clinicians don't need more noise or we don't need more black boxes. We need decision support that is clear, that we can interpret, and that is actionable. “Why are you using this? Why did we choose this drug? Why this dose? Why now?” So, all these things are going to help us and that allows us to trace evidence with a single click. So, I always call it back to the Moravec's paradox where we say, you know, evolution gave us so much energy to discern in the sensory-neural and dexterity. That's what we're going to be taking care of patients. We can use AI to really be a force to help us to be better clinicians and not to really replace us. So, if we get this right and we decide for transparency with trust, inclusion, etc., it will never replace any of our work, which is so important, as much as we want, we can actually take care of patients and be personalized, timely, and equitable. So, all those things are what get me excited every single day about these conversations on AI. Dr. Paul Hanona: All great thoughts, Dr. Bonilla. I'm very excited to see how this field evolves. I'm excited to see how oncologists really come to this field. I think with technology, there's always a bit of a lag in adopting it, but I think if we jump on board and grow with it, we can do amazing things for the field of oncology in general. Thank you for the advancements that you've made in your own career in the field of AI and oncology and just ultimately with the hopeful outcomes of improving patient care, especially cancer patients. Dr. Arturo Loaiza-Bonilla: Thank you so much, Dr. Hanona. Dr. Paul Hanona: Thanks to our listeners for your time today. If you value the insights that you hear on ASCO Daily News Podcast, please take a moment to rate, review, and subscribe wherever you get your podcasts. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. More on today's speakers: Dr. Arturo Loaiza-Bonilla @DrBonillaOnc Dr. Paul Hanona @DoctorDiscover on YouTube Follow ASCO on social media: @ASCO on Twitter ASCO on Facebook ASCO on LinkedIn ASCO on BlueSky Disclosures: Paul Hanona: No relationships to disclose. Dr. Arturo-Loaiza-Bonilla: Leadership: Massive Bio Stock & Other Ownership Interests: Massive Bio Consulting or Advisory Role: Massive Bio, Bayer, PSI, BrightInsight, CardinalHealth, Pfizer, AstraZeneca, Medscape Speakers' Bureau: Guardant Health, Ipsen, AstraZeneca/Daiichi Sankyo, Natera
And now for something completely different, as Ben Robinson (Space Oddities, Geeksploration) hosts a very special episode. Matt and Aaron form Team Gamesmaster to take on Audra and Steve Wetherell (Authors & Dragons, author). Will our players succeed in their quest to find the Holy Grail? Or will it all just be very silly actually?Send your Monty Python muses and inspirations to gateleapers@gmail.comSupport our PlayersListen to Authors & DragonsRead ThaneListen to BFYTWFollow Audra StephensonWe are an ad and listener supported podcast, but mainly listener supported. Consider supporting our production over at patreon.com/gateleapers. All supporters get ad-free audio episodes. Premium supporters get video recordings + a bonus monthly episode.Do you have a suggestion for a fandom we've not yet covered? Are you a podcaster, creative or performer who would like to be a guest on our show? Get in touch! gateleapers@gmail.comMusic: BoucheDag by Alexander Nakarada (serpentsoundstudios.com)Licensed under Creative Commons BY Attribution 4.0 Licensehttps://creativecommons.org/licenses/by/4.0/Become a supporter of this podcast: https://www.spreaker.com/podcast/gateleapers-a-fandom-gameshow--5150861/support.
Send us a textLaughter might be the best medicine, but finding the perfect comedy film can sometimes feel like a quest for the Holy Grail. Fresh off our deep dive into the health benefits of laughter, we're now counting down the 10 funniest movies of all time – a subjective yet passionate ranking guaranteed to spark debate among comedy aficionados everywhere.From Will Ferrell's quotable antics in Anchorman to the subtle genius of Monty Python, we explore what makes these films stand the test of time. Why do certain lines stick with us for decades? How does comedy evolve yet somehow stay timeless? And why can we watch these movies repeatedly, knowing the punchlines, yet still laugh just as hard?Our countdown traverses various comedy styles – from the mockumentary brilliance of This is Spinal Tap to the boundary-pushing satire of Blazing Saddles and the cringe-worthy scenarios of Borat. Each film earns its place through some combination of quotability, originality, cultural impact, and pure laugh-out-loud moments that leave your sides hurting.The episode kicks off with our "Winner of the Week" segment featuring an incredible story about a woman who remembered her CPR training from 40 years prior to save a teenager's life during a baseball practice. This real-life hero kept the rhythm of chest compressions by humming "Staying Alive" by the Bee Gees – proving that sometimes the right soundtrack can literally save lives.Whether you're looking to expand your comedy watchlist or eager to challenge our rankings with your own favorites, this episode celebrates the films that bring joy, relief, and healing through laughter. And remember – watching a great comedy isn't just entertainment; it's a form of self-care that releases those mood-boosting endorphins your brain craves.Subscribe now, and don't forget to text "hypnosis" to 313-800-8510 for your free hypnosis guide and a chance to leave us a review!FIND ME:My Website: https://motorcityhypnotist.com/podcastMy social media links: Facebook: https://www.facebook.com/motorcityhypnotist/YouTube: https://www.youtube.com/channel/UCCjjLNcNvSYzfeX0uHqe3gATwitter: https://twitter.com/motorcityhypnoInstagram: motorcityhypnoFREE HYPNOSIS GUIDEhttps://detroithypnotist.convertri.com/podcast-free-hypnosis-guidePlease also subscribe to the show and leave a review.(Stay with me as later in the podcast, I'll be giving away a free gift to all listeners!)Change your thinking, change your life!Laugh hard, run fast, be kind. David R. Wright MA, LPC, CHTThe Motor City Hypnotist
The Jesus bloodline refers to the proposition that a lineal sequence of the historical Jesus has persisted, possibly to the present time. Although absent from the Gospels or historical records, the concept of Jesus having descendants has gained a presence in the public imagination, as seen with Holy Blood, Holy Grail a book by Michael Baigent, Richard Leigh, and Henry Lincoln and Dan Brown's 2003 best-selling novel The Da Vinci Code. These claimed Jesus's bloodlines are distinct from the biblical genealogy of Jesus, which concerns the ancestors of Jesus, and from the alleged Brothers of Jesus and other kin of Jesus, known as the Desposyni. Joel continues to peel back the layers shrouding the mystery of the supposed Bloodlines of Jesus Christ. He looks at the origins of the Knights Templar and how their roots go back to not only the Priory of Sion but Rex Deus and the Essenes. He then takes a look at the hidden relationship between the Templars and the Islamic Assassins and how they both professed outwardly their devotion to Christianity and Islam but secretly practiced esoteric Gnosticism coupled with devotion to hiding hidden bloodlines. He also peers into Rosslyn Chapel, the secrets it holds, including Freemasonic treasures along with the Holy Grail. Finally, Joel lays out the Gnostic blueprint for hiding the genealogy of Jesus and Mary Magdalene and what became of their purported children. Buy Me A Coffee: Donate Website: https://linktr.ee/joelthomasmedia Follow: Instagram | X | Facebook Watch: YouTube | Rumble Music: YouTube | Spotify | Apple Music Films: merkelfilms.com Email: freetherabbitspodcast@gmail.com Distributed by: merkel.media Produced by: @jack_theproducer INTRO MUSIC Joel Thomas - Free The Rabbits YouTube | Apple Music | Spotify OUTRO MUSIC Joel Thomas - Imposter YouTube | Apple Music | Spotify
Book a Call for Founder OS: https://fos.now/yt-apply-46In this video, I reveal why smart, ambitious people stay stuck despite having all the tools for success.After surveying 99 ambitious people in my community, I discovered the same 10 core problems that keep them trapped - even when they look successful on paper.You'll see the exact survey results and the systems I use to help founders get unstuck, including the AED Machine that transforms how you spend your time.Get my free AED Machine here: https://fos.now/yt-discover-time-audit-system-1Get my free Unstuck Playbook here: https://fos.now/yt-discover-the-unstuck-playbookGet my free Holy Grail of Psychological Branding here: https://fos.now/yt-discover-holy-grail-psychologicial-brandingVideo title ideas (for the algo):Why 99% of Ambitious People Stay StuckIf You're Smart and Ambitious, Why Are You Still Stuck?97% of You Will Make These Mistakes (Unless You Watch This First)These 10 Mistakes Will Determine Your Success for the Next 5 YearsConnect with me:My website: https://fos.now/yt-founder-os-46Twitter: https://twitter.com/matt_gray_LinkedIn: https://www.linkedin.com/in/mattgray1TikTok: https://www.tiktok.com/@realmattgrayInstagram: https://instagram.com/matthgrayWant to LEARN proven systems to grow your personal brand? Go here: https://fos.now/yt-newsletter-4600:00 - Intro01:19 - Problem 1: I'm Stuck In The Weeds02:14: - Problem 2: Hired OPS But Still Stuck03:10 - Problem 3: High-Ticket Pricing05:40 - Problem 4: Offer Isn't Converting06:32 - Problem 5: Scale Without A Big Team08:43 - Problem 6: Content With No Sales09:30 - Problem 7: I Think Ads Will Save Me11:17 - Problem 8: Hiring Causes Major Stress13:31 - Problem 9: Attracting Wrong Clients15:43 - Problem 10: I Can't Travel#onepersonbusiness #creatoreconomy #entrepreneurship
'Tis but a scratch! This week on Cocktails & Classics, we embark on a ridiculous quest with the legendary 1975 comedy, "Monty Python and the Holy Grail." Join us as we laugh our way through King Arthur's absurd journey, killer bunnies, and insulting Frenchmen. We'll dissect the film's unique comedic style, its quotable lines, and its enduring influence on pop culture. Feeling silly? Craft a classic cocktail while you listen! Don't miss this episode for a hilarious deep dive into a timeless comedic masterpiece, fueled by classic cocktails and gloriously silly discussions.Monty Python's Unique Humor: Analyze the distinct comedic style of the Monty Python troupe, including surrealism, silliness, satire, and breaking the fourth wall.Pop Culture Impact: From memorable characters and infinitely quotable lines, we take a look at how the film has permeated pop culture. Low-Budget Brilliance: We discuss how the film's constrained budget led to creative and iconic comedic choices (e.g., coconuts for horses & multiple roles for actors).Thematically, What is it About? Beyond the laughs, is there any underlying commentary or message? (e.g., quest for meaning, absurdity of life, class critique).What's your favorite "Monty Python and the Holy Grail" quote or absurdist moment? Share your thoughts and funniest film experiences on Instagram! #CocktailsAndClassics Don't forget to share this hilariously absurd episode with your friends and family! Subscribe and leave a rating wherever you listen.
Chad Brendel and David Simone discuss the week that was Cincinnati Bearcats live from the Cincy Light Studios. They kick off the show with the Chief Creative Officer of the University of Cincinnati, Dan Phillips, to discuss today's unveiling of the new jerseys for the Bearcats football team. They follow that up with a look around the Big 12 Conference with Brien Hanley of Big 12 Insiders. They cap things off putting a bow on the conference talk with a look ahead to Big 12 Media Days. Join the conversation live every Wednesday night at 8pm on the Bearcat Journal Twitch and YouTube channels, and don't forget to like and subscribe while you're there! Turtle's Brew Time Stamps 0:00 - 30:00 Chief Creative Officer Dan Phillips 30:00 - 1:15:00 Brien Hanley of Big 12 Insiders 1:15:00 - 1:35:29 Big 12 Media Days
An interview us found footage fans (say that 3 times fast) have been waiting for! Thanks to Dean Alioto ("The McPherson Tape," "The Last Podcast"), we're joined tonight by Philip Escott & Sarah Appleton, the director & co-director of the incredible 2021 documentary that is streaming on Shudder, "The Found Footage Phenomenon." This is the found footage freaks Holy Grail when it comes to documentaries. It covers the early history of POV shots, fake snuff films, the Blair Witch Project boom and where the state of found footage films are today. We really appreciate Sarah & Philip lending their time, we had a blast and we hope you guys enjoy! 'Salem's Secret' by Peter Gundry Merchandise: https://dfwtopodcast.creator-spring.com/ Sponsored by: Dietsmoke.com - use promo code DFWTO for 50% off your purchase Betterhelp: Visit betterhelp.com/dfwto to get 10% off when you sign up for your first month.
Welcome to the second episode of The Holy Grail of Investing podcast! In this fascinating conversation, my co-hosts ChristopherZook and Mark Wade of CAZ Investments, sit down with Michael Rees, Co-President of Blue Owl Capital to unpack the asset class known as GP Stakes. This strategy has grown geometrically over the past decade and is rapidly becoming one of the more coveted strategies among the world's most sophisticated investors who want broad exposure to Private Equity. Watch this episode now on YouTube at @TonyRobbinsLive Learn more at www.TheHolyGrailofInvesting.com and www.CAZInvestments.com "The Holy Grail of Investing podcast is about more than just investing—it's about giving listeners a front-row seat to how some of the world's greatest investors think,” said Tony Robbins. “These conversations usually happen behind closed doors, and now we are making them available to a much broader audience—even those just starting to explore private market opportunities.” Hosted by Tony Robbins and investor Christopher Zook, this new podcast offers rare, behind-the-scenes conversations with legendary private market investors—exploring not just how they invest, but why they do what they do.
These lectures will explore two Arthurian romances, Chretien de Troyes' Knight of the Cart, and the Cistercian text we know as The Quest of the Holy Grail, through the lens of Catholic teaching on redemption, divine grace, and the pursuit of virtue.
The Jesus bloodline refers to the proposition that a lineal sequence of the historical Jesus has persisted, possibly to the present time. Although absent from the Gospels or historical records, the concept of Jesus having descendants has gained a presence in the public imagination, as seen with Holy Blood, Holy Grail a book by Michael Baigent, Richard Leigh, and Henry Lincoln and Dan Brown's 2003 best-selling novel The Da Vinci Code. These claimed Jesus's bloodlines are distinct from the biblical genealogy of Jesus, which concerns the ancestors of Jesus, and from the alleged Brothers of Jesus and other kin of Jesus, known as the Desposyni. Walk with Joel as he digs through a mountain of secret societies, gnostic sects and proposed genealogies to uncover the truth of these so-called "hidden" bloodlines of Jesus. He looks at the Desposyni vs. Rex Deus and if there is any correlation between the two. He then uncovers the Rennes-le-Château, Father Bérenger Saunière and the secrets they both were said to possess. Lastly, Joel looks at the mysterious Priory of Sion and the supposed hoaxer, Pierre Plantard, who was behind it and if the list of masters were indeed hiding Merivingian bloodlines. Buy Me A Coffee: Donate Website: https://linktr.ee/joelthomasmedia Follow: Instagram | X | Facebook Watch: YouTube | Rumble Music: YouTube | Spotify | Apple Music Films: merkelfilms.com Email: freetherabbitspodcast@gmail.com Distributed by: merkel.media Produced by: @jack_theproducer INTRO MUSIC Joel Thomas - Free The Rabbits YouTube | Apple Music | Spotify OUTRO MUSIC Joel Thomas - Imposter YouTube | Apple Music | Spotify
It's time for The Last Crusade! (Until the other two - which we don't talk about, unless we're making podcasts about them). Indiana Jones is back doing what he does best - punching Nazis, saving loved ones, and somehow doubting the existence of the divine despite being on-site when a biblical artifact melted a squad of German troops. This time he's after the sippy cup of Jesus H Christmas himself, the holy grail of archaeological finds - the actual Holy Grail. Oh and his father, whose academic rigour and emotional distance colour in acres of Indy's backstory. Join us!Let us know what you think of this format by emailing us at redshirtcinemaclub@gmail.com and support us on Patreon at patreon.com/redshirtcinemaclub for access to twobonus episodes per month as well as our newsletter, The Civilian Observer. Hosted on Acast. See acast.com/privacy for more information.
What if the symbols lining your currency, the rituals behind closed doors, and the headlines dominating your feed were all part of the same ancient strategy? From Babel to Bohemian Grove, this chilling deep dive tracks the fingerprints of three rising powers—working in sync, hiding in plain sight. Their roots stretch from fallen angels to global councils, their goals stitched into history, politics, and religion. Everything is in motion. The curtain is thin. The beasts are not coming—they're already here. Check out "Secret Societies" by Micah Van Huss HERE! https://www.swrc.com/product/secret-societies-pre-order/ Visit us online: https://www.swrc.com/
Some secrets are hidden in plain sight—tucked behind marble walls, locked in museum vaults, and buried beneath official silence. What if the stories we're told are just the cover page? From ancient blueprints of rebellion to elite circles shaping policy and power, this gripping investigation tracks patterns most overlook. The threads trace through temples, revolutions, experiments, and empires—until they lead to the door no one wants opened. Check out "Secret Societies" by Micah Van Huss HERE! https://www.swrc.com/product/secret-societies-pre-order/ Visit us online: https://www.swrc.com/
Power doesn't always wear a crown—sometimes it hides behind curtains. This gripping exposé cracks the polished surface of world history to spotlight the hands behind the levers. From ancient Babel to global agendas, it traces the thread of hidden influence through secret alliances, shadowy rituals, and generational power brokers. The symbols are all around us. The stakes stretch beyond borders. The pattern is older than empires and it hasn't gone quiet. Check out "Secret Societies" by Micah Van Huss HERE! https://www.swrc.com/product/secret-societies-pre-order/ Visit us online: https://www.swrc.com/
This episode I talk about the red Ric Flair Big Rubber Guys figure, a Randy Savage LJN Repaint & Holy Grails before 5 Star Eric joins me with Night Of Champions predictions. "Andre" Karaoke closes out the show. Thanks very much for your support
Across time and cultures, legendary quests have shaped the way we see heroism, destiny, and the divine. In this episode of Mythlok, your host Nitten Nair takes you on a cinematic journey through the most iconic mythical adventures — from Gilgamesh's search for immortality, Odysseus' long road home, and Jason's quest for the Golden Fleece, to Rama's battle against evil and the pursuit of the Holy Grail. Inspired by the storytelling tone of Sir David Attenborough, this immersive episode explores how these quests reflect our own search for meaning, courage, and truth.
The simplicity of life back then is appealing today, as long as you don't mind Church hegemony, the occasional plague, trial by gossip — and the lack of ibuprofen. (Part two of a three-part series, “Cradle to Grave.”) SOURCES:Jordan Cavalier, performer at the New Jersey Renaissance Faire.Matt Schwarz, harpist at the New Jersey Renaissance Faire.Phillipp Schofield, professor of history at Aberystywth University.Neslihan Şenocak, professor of history at Columbia University. RESOURCES:A People's Church: Medieval Italy and Christianity, 1050–1300, co-edited by Agostino Paravicini Bagliani and Neslihan Şenocak (2023).The Routledge Handbook of Medieval Rural Life, edited by Miriam Müller with a contribution by Phillip Schofield (2021).Monty Python and the Holy Grail, film (1975). EXTRAS:"Are You Having a Midlife Crisis?" by No Stupid Questions (2022).
Talking points: myth, psychology, purposeI've loved myths and legends since I was a kid. As a man, that love has only grown because they can serve up powerful, meaningful guidance. So this week, we're digging into what Arthur, Excalibur, and the Holy Grail teach about the journey of the mature masculine.(00:00:00) - Intro(00:02:38) - Boyhood, coming of age, and crossing the thresholds of manhood(00:07:45) - The symbol and importance of Excalibur(00:16:04) - The sword in the stone CAN'T be pulled by might(00:18:33) - The meaning of pursuing the “holy grail”(00:22:36) - Purpose and ego don't usually mix
The Summer 2025 HardLore Q&A Special has arrived, we answered a huge array of questions from our Patreon and Discord ranging from our thoughts on Turnstile's new album "Never Enough", the spinkick heard 'round the world, our favorite merch designs ever, how we'd rank every Metallica album ever, and MUUUUCH more. Enjoy our favorite type of episode to do!Edited by Steven Grise (@iamoneonenineseven) • Title sequence by Nicholas Marzluf (@marzluf) HardLore: A Knotfest Series Join the HARDLORE PATREON to watch every single weekly episode early and ad-free, alongside exclusive monthly episodes: https://patreon.com/hardlorepod Join the HARDLORE DISCORD: https://discord.gg/jA9rppggef Cool links: Get 15% off MADD VINTAGE with code HARDLORE15! https://maddvintage.com/ FOLLOW HARDLORE: INSTAGRAM | https://www.instagram.com/hardlorepod/ TWITTER | https://twitter.com/hardlorepod SPOTIFY | https://spoti.fi/3J1GIrp APPLE | https://apple.co/3IKBss2 FOLLOW COLIN: INSTAGRAM | https://www.instagram.com/colinyovng/ FOLLOW BO: INSTAGRAM | https://www.instagram.com/bosxe/ TWITTER | https://www.twitter.com/bosxe #HARDLORE #HARDCORE00:00:00 - Start00:01:08 - Hello Welcomee00:02:11 - Harms Way Tour Recap00:06:35 - Special Announcement....00:06:50 - Tied Down 202500:13:54 - Patreon Q&A Begins00:15:18 - Best and Worst Meal of Tour00:17:50 - Metallica Albums Ranked00:22:51 - Best Advice Ever Received00:24:04 - Favorite High School memory00:27:47 - New Music Soon?00:28:07 - Mt. Rushmore of Hatebreed Tracks00:30:41 - Frank Iero00:33:05 - Followed by an Alien00:34:01 - Lightsabers00:35:32 - Deathcore00:37:28 - Bands Needing to Push the Envelope00:41:43 - Touring in A Van vs Touring in a Bus00:46:20 - Hardcore Not F****** With Metalcore00:47:11 - Bucket List for Traveling00:49:48 - What Went Into Twitchfits Vol 200:51:45 - Best HC Merch Designs00:52:03 - Pardon This Interruption…00:56:09 - The Process of Doing Guest Vocals00:56:56 - Top 5 TV Shows00:59:32 - Glow Ups and Podcasts01:00:45 - Best Needle Drop in TV / Movies01:02:50 - Turnstile01:04:10 - Hardest riffs in your own bands01:07:29 - Top 4 animated movies01:14:21 - All Time Favorite Indie Wrestling Match01:15:05 - Predicting Rushmore of Modern Hardcore01:18:20 - Bo's Skin Care Routine01:19:18 - Rushmore of Weightlifting Records01:21:30 - Holy Grail of Lost Media01:22:27 - Dahmer Party?01:22:44 - Age Limit to claim Edge01:23:54 - When Tours Cross Paths...01:26:12 - ideal Breakfast Spread01:26:49 - Lal Mirch Order01:28:54 - Mikkey Dee on the Pod when?
I'm back this week with four more shipwreck stories. We'll start with the horrific explosion of the Mississippi river steamboat, the Sultana in 1865. Next, we'll tackle the Titanic which famously sank in 1912, killing around 1,500 passengers. On to another famous ship, the Endeavor. The Endeavor was the British naval ship used by explorer Captain James Cook during his first voyage of discovery which landed him in Australia, New Zealand, and Tahiti in the mid 1700s. Later the ship changed hands and was eventually used and intentionally sunk during the American Revolutionary War. Finally, I'll end with what is, quite possibly, one of the most controversial shipwrecks ever found, the San Jose. This Spanish galleon has been called the "holy grail" of shipwrecks because it was supposedly carrying treasure worth up to 17 billion dollars today when it went down in 1708. As five plus countries argue over the San Jose's treasure, the ethical question remains - what should be done with these shipwrecks?Support the show! Join the Patreon (patreon.com/historyfixpodcast)Buy some merchBuy Me a CoffeeVenmo @Shea-LaFountaineSources: American Battlefield Trust "The Sultana Disaster"Wikipedia "Sultana"New York Times "Civil War Hull Is Reported Found"Live Science "Digital "resurrection" of the Titanic sheds light on fateful night the ship tore apart"National Geographic Press Release "National Geographic reveals groundbreaking underwater scan..."The Times "At last, the Titanic wreck is left to rust in peace"Wikipedia "James Cook"Australian National Maritime Museum "Evidence Identifying Endeavor"The Guardian "Discovery provides further evidence shipwreck is Captain Cook's Endeavor, maritime scientists say"The Guardian "Worm-eaten shipwreck of Captain Cook's Endeavor under threat from more marine animals"BBC "The fierce battle over over the 'Holy Grail' of shipwrecks"Shoot me a message!
As our financial system is in the process of undergoing drastic changes, we may have to contend with something called the GENIUS Act. GENIUS is an acronym for Guiding and Establishing National Innovation for U.S. Stablecoin. It would be the digital and financial Holy Grail for the Surveillance State. However, President Trump is signaling a strong interest in gold; the idea of a gold-backed monetary shift is no longer just speculation—it may be part of the broader monetary realignment already in motion. It is a great alternative to stablecoin surveillance money. Tonight on Ground Zero with Clyde Lewis and financial analyst, Alan Johnson, starting at 7 pm, pacific time on groundzeroplus.com. Call in to the LIVE show: 503-225-0860 #groundzeroplus #ClydeLewis #gold #stablecoin
Long before the Allies stormed Berlin, a different kind of war was already underway—waged not with bullets and tanks, but with relics, runes, and ancient symbols of power. This three-part series unearths the chilling true story of the Nazis' obsession with the occult and their state-sponsored quest for the Holy Grail. At the center of it all was SS leader Heinrich Himmler, who transformed a crumbling medieval ruin—Wewelsburg Castle—into a spiritual fortress and ritual temple for a cult hiding in plain sight. From secret SS expeditions in search of relics to fabricated sacred texts and blood-soaked ceremonies in the castle's north tower, The Devil Within reveals how myth, pseudoscience, and fanaticism merged into something far more dangerous: belief weaponized. And when the war was lost, Wewelsburg didn't die. The Black Sun chamber survived. And the thirteenth pedestal—the one reserved for the Grail—remains empty to this day.
Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 3173: Craig Stephens explores the four types of travelers based on time and money - backpackers, vacationers, broke people, and financially independent travelers. He shares his journey from a budget traveler to someone working toward financial independence to achieve long-term, comfortable global travel without time or financial constraints. Stephens emphasizes the strategic savings and investing necessary to reach the ultimate goal: the freedom to travel anytime, anywhere, in comfort. Read along with the original article(s) here: https://www.retirebeforedad.com/holy-grail-of-travel/ Quotes to ponder: "Financial independence allows for travel for any period of time without the pressure to return and start or resume a career." "Depending on level of comfort, backpackers can travel for very little money for long periods of time." "It makes more sense from a cost perspective to fly to another part of the world and stay for two months than to take a week-long cruise." Episode references: Camino de Santiago: https://caminoways.com/camino-de-santiago Learn more about your ad choices. Visit megaphone.fm/adchoices
A historian, a journalist, and a developer answer a host's questions regarding the Sony State of Play, various consistencies of pie, and video game drag names. Hosted by Alex Jaffe, with Frank Cifaldi, Ash Parrish, Brandon Sheffield. Edited by Esper Quinn, original music by Kurt Feldman. Watch episodes with full video on YouTube Discuss this episode in the Insert Credit Forums SHOW NOTES: “Gold Saucer? Take that shit and throw it straight in the trash!” Video Game History Foundation Nintendo DS TurboGrafx-16 This Is Why You're Prone to Crying on Airplanes 1: Do we have any thoughts on the Sony State of Play yesterday? (06:02) Sony June 4 State of Play We're Dumping 125 Mystery Prototype ROMs! E3 Al Yang Silent Hill f Monty Python and the Holy Grail (1975) Summer Games Fest Xbox Games Showcase 2025 Copilot AI Bill Gates Joel McHale Seth Green 2: Does anyone have any stories about pie? (12:00) “A Week in the Life of a Demonschool Student” trailer Ash's Xbox green outfit Gamegate (harrassment campaign) House of Pies Bubba Gump Shrimp Company Game Changer Kris Graft Katatonia 3: What is the best video game you know you'll never play? (18:40) Deltarune Undertale Fortnite FromSoftware Bloodborne Echo Night Demon's Souls Elden Ring Soul Blazer Tetris Effect Lumines Arise PlayStation Portable Chrono Trigger Baldur's Gate III Street Fighter III: 3rd Strike Capcom vs. SNK 2: Mark of the Millennium Patrick Miller 4: Happy pride! Let's come up with some video game themed drag names (24:04) Master Chief Point and Click Adventure Final Fantasy series Sephiroth Ruth Bader Ginsburg Street Fighter series Ken Masters M. Bison Blanka Sonic the Hedgehog series Knuckles the Echidna Amy Rose Cream the Rabbit SNK Karnov's Revenge Terry Bogard Dizzy the Egg Geese Howard Dizzy Guilty Gear series Mortal Kombat series Sonya Blade Johnny Cage Kung Lao 5: James asks, I had a dream where Alex Jaffe told me “You can't say that, there's only one pun that's allowed at insert credit summer camp.” What's that pun? Also, what's insert credit summer camp like? (29:26) Insert Credit Patreon Gacha Machine Noob Saibot Mr. Driller Playdate Tilden Park Little Farm Tom Braider Rain Jerks Tony Hawk's Pro Skater 2 September 11 attacks Mega Man Battle Network 6: What's the most work you've put into a video game related project that never really went anywhere? (37:39) Square Enix Nintendo Entertainment System GDC Harvey Weinstein Dr. Disrespect 7: What is the Bride of Frankenstein of video games? (45:07) The Bride of Frankenstein (1935) Ms. Pac-Man Bayonetta series Devil May Cry series Mass Effect 3 ending controversy Guile Marge Simpson LIGHTNING ROUND: GameFAQ&As - The Sims 4 (48:30) Recommendations and Outro (53:47): Brandon: Dr. Bronner makes chocolate now, The Singing Thief (1969), Whorepion Frank: Don't piss your pants, open the door instead Ash: D'Hora, Liu Sang, Ho' Rai Cho, Ho'tal Khan, Jackoffson Briggs, Chronica Jaffe: Sign up for Patreon to receive your gacha pull! This week's Insert Credit Show is brought to you by patrons like you. Thank you. This week's horrible buzzer was sent in by zx.crux. Thanks! To submit your own horrible buzzer, send an original recording no longer than two seconds in mp3 or wav format to show@insertcredit.com, and maybe we'll use it on the show! Subscribe: RSS, YouTube, Apple Podcasts, Spotify, and more!
A historian, a journalist, and a developer answer a host's questions regarding the Sony State of Play, various consistencies of pie, and video game drag names. Hosted by Alex Jaffe, with Frank Cifaldi, Ash Parrish, Brandon Sheffield. Edited by Esper Quinn, original music by Kurt Feldman. Watch episodes with full video on YouTube Discuss this episode in the Insert Credit Forums SHOW NOTES: “Gold Saucer? Take that shit and throw it straight in the trash!” Video Game History Foundation Nintendo DS TurboGrafx-16 This Is Why You're Prone to Crying on Airplanes 1: Do we have any thoughts on the Sony State of Play yesterday? (06:02) Sony June 4 State of Play We're Dumping 125 Mystery Prototype ROMs! E3 Al Yang Silent Hill f Monty Python and the Holy Grail (1975) Summer Games Fest Xbox Games Showcase 2025 Copilot AI Bill Gates Joel McHale Seth Green 2: Does anyone have any stories about pie? (12:00) “A Week in the Life of a Demonschool Student” trailer Ash's Xbox green outfit Gamegate (harrassment campaign) House of Pies Bubba Gump Shrimp Company Game Changer Kris Graft Katatonia 3: What is the best video game you know you'll never play? (18:40) Deltarune Undertale Fortnite FromSoftware Bloodborne Echo Night Demon's Souls Elden Ring Soul Blazer Tetris Effect Lumines Arise PlayStation Portable Chrono Trigger Baldur's Gate III Street Fighter III: 3rd Strike Capcom vs. SNK 2: Mark of the Millennium Patrick Miller 4: Happy pride! Let's come up with some video game themed drag names (24:04) Master Chief Point and Click Adventure Final Fantasy series Sephiroth Ruth Bader Ginsburg Street Fighter series Ken Masters M. Bison Blanka Sonic the Hedgehog series Knuckles the Echidna Amy Rose Cream the Rabbit SNK Karnov's Revenge Terry Bogard Dizzy the Egg Geese Howard Dizzy Guilty Gear series Mortal Kombat series Sonya Blade Johnny Cage Kung Lao 5: James asks, I had a dream where Alex Jaffe told me “You can't say that, there's only one pun that's allowed at insert credit summer camp.” What's that pun? Also, what's insert credit summer camp like? (29:26) Insert Credit Patreon Gacha Machine Noob Saibot Mr. Driller Playdate Tilden Park Little Farm Tom Braider Rain Jerks Tony Hawk's Pro Skater 2 September 11 attacks Mega Man Battle Network 6: What's the most work you've put into a video game related project that never really went anywhere? (37:39) Square Enix Nintendo Entertainment System GDC Harvey Weinstein Dr. Disrespect 7: What is the Bride of Frankenstein of video games? (45:07) The Bride of Frankenstein (1935) Ms. Pac-Man Bayonetta series Devil May Cry series Mass Effect 3 ending controversy Guile Marge Simpson LIGHTNING ROUND: GameFAQ&As - The Sims 4 (48:30) Recommendations and Outro (53:47): Brandon: Dr. Bronner makes chocolate now, The Singing Thief (1969), Whorepion Frank: Don't piss your pants, open the door instead Ash: D'Hora, Liu Sang, Ho' Rai Cho, Ho'tal Khan, Jackoffson Briggs, Chronica Jaffe: Sign up for Patreon to receive your gacha pull! This week's Insert Credit Show is brought to you by patrons like you. Thank you. This week's horrible buzzer was sent in by zx.crux. Thanks! To submit your own horrible buzzer, send an original recording no longer than two seconds in mp3 or wav format to show@insertcredit.com, and maybe we'll use it on the show! Subscribe: RSS, YouTube, Apple Podcasts, Spotify, and more!
These lectures will explore two Arthurian romances, Chretien de Troyes' Knight of the Cart, and the Cistercian text we know as The Quest of the Holy Grail, through the lens of Catholic teaching on redemption, divine grace, and the pursuit of virtue.
Welcome to the debut episode of The Holy Grail of Investing, a new podcast from Tony Robbins and Christopher Zook, inspired by their #1 New York Times bestselling book. In this premier conversation, we sit down with Robert F. Smith, Founder, Chairman, and CEO of Vista Equity Partners, to explore how he built one of the most successful private equity firms in the world with over $100 billion in assets under management. Smith shares the story behind Vista's rise, how engineering principles inform his investment philosophy, and the how AI is impacting technology companies and creating extraordinary efficiencies. Watch this episode now on YouTube at @TonyRobbinsLive Learn more at www.TheHolyGrailofInvesting.com and www.CAZInvestments.com "The Holy Grail of Investing podcast is about more than just investing—it's about giving listeners a front-row seat to how some of the world's greatest investors think,” said Tony Robbins. “These conversations usually happen behind closed doors, and now we are making them available to a much broader audience—even those just starting to explore private market opportunities.” Hosted by Tony Robbins and investor Christopher Zook, this new podcast offers rare, behind-the-scenes conversations with legendary private market investors—exploring not just how they invest, but why they do what they do.