Advances in Women's Health

Host: Charles Turck, PharmD, BCPS, BCCCP Guest: Ayman Al-Hendy, MD, PhD, FRCSC, FACOG, CCRP Despite longstanding reliance on surgery, recent advancements have reshaped our approach to uterine fibroids. However, common myths and misconceptions have limited the adoption of newer therapies, leaving many patients unaware of their available options. Join Dr. Charles Turck and Dr. Ayman Al-Hendy as they explain shifting treatment paradigms and patient education strategies in uterine fibroid care. Dr. Al-Hendy is a Professor of Obstetrics and Gynecology and the Director of Translational Research at the University of Chicago Pritzker School of Medicine.

Guest: Jennifer L. Payne, MD Guest: Melissa Simon, MD Since postpartum depression is a serious medical condition that can negatively impact mothers, infants, and partners, it is important to identify symptoms in a timely manner.1-4 Dr. Jennifer Payne and Dr. Melissa Simon are here to share their clinical experiences screening patients for postpartum depression, explore strategies to overcome common challenges in screening, and identify best practices for collaborating in the care of perinatal women. Dr. Payne is a Professor of Psychiatry and Neurobehavioral Sciences as well as Obstetrics and Gynecology at the University of Virginia, and Dr. Simon is a Professor of Obstetrics and Gynecology at the Northwestern University Feinberg School of Medicine. References American Psychiatric Association. Depressive disorders. In: American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders: DSM-5™. 5th ed. American Psychiatric Publishing; 2013:155-188. Campbell SB, Cohn JF, Meyers T. Depression in First-Time Mothers: Mother-Infant Interaction and Depression Chronicity. Dev Psychol. 1995;31:349-357. Moore Simas TA, Huang MY, Patton C, et al. The humanistic burden of postpartum depression: a systematic literature review. Curr Med Res Opin. 2019;35(3):383-393. Thompson KS, Fox JE. Post-partum depression: a comprehensive approach to evaluation and treatment. Ment Health Fam Med. 2010;7(4):249-257. Sage Therapeutics and the Sage Therapeutics logo …

Host: Matt Birnholz, MD Guest: Jennifer L. Payne, MD Guest: Melissa Simon, MD Postpartum depression is a serious medical condition that is among the most common complications during and after pregnancy; however, it is often underdiagnosed.1-4 To learn more about screening patients for postpartum depression, Dr. Matt Birnholz speaks with Dr. Jennifer Payne and Dr. Melissa Simon about screening strategies, the impact of health inequities, and the latest medical guidelines regarding the importance of early screening for postpartum depression. Dr. Payne is a Professor of Psychiatry and Neurobehavioral Sciences as well as Obstetrics and Gynecology at the University of Virginia, and Dr. Simon is a Professor of Obstetrics and Gynecology at the Northwestern University Feinberg School of Medicine. References American Psychiatric Association. Depressive disorders. In: American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders: DSM-5™. 5th ed. American Psychiatric Publishing; 2013:155-188. Bauman BL, Ko JY, Cox S, et al. Vital Signs: Postpartum Depressive Symptoms and Provider Discussions About Perinatal Depression - United States, 2018. MMWR Morb Mortal Wkly Rep. 2020;69(19):575-581. Cox EQ, Sowa NA, Meltzer-Brody SE, Gaynes BN. The Perinatal Depression Treatment Cascade: Baby Steps Toward Improving Outcomes. J Clin Psychiatry. 2016;77(9):1189-1200. Thompson KS, Fox JE. Post-partum depression: a comprehensive approach to evaluation and treatment. Ment Health Fam Med. 2010;7(4):249-257. …

Host: Mary Katherine Cheeley, PharmD, BCPS, CLS, FNLA Guest: Leigh Anne Cantrell, MD, MSPH The updated ASCCP guidelines now address the use of dual-stain technology for cervical cancer management. CINtec PLUS Cytology is a test for the co-expression of p16 and Ki67 and confirms the presence of a transforming HPV infection and defines patients with high-risk cervical disease. To learn more about these guidelines and how to apply them in practice, join Dr. Leigh Cantrell, Medical Physician and Fellow in the American College of Obstetrics and Gynecology. COBAS and CINTEC are trademarks of Roche.All other product names and trademarks are the property of their respective owners. 07/24

Host: Matt Birnholz, MD Guest: Kay Matthews, LCHW Ms. Kay Matthews has lived experience with postpartum depression and now advocates for others as the Executive Director and Founder of Shades of Blue, which is dedicated to breaking cultural barriers in maternal mental health. Tune in to hear her speak with Dr. Matt Birnholz about her journey with postpartum depression, barriers that can prevent or delay patients from seeking care, and strategies for combatting stigma and ensuring a timely diagnosis. Sage Therapeutics and the Sage Therapeutics logo are registered trademarks of Sage Therapeutics, Inc.Sage Therapeutics, Inc. All rights reserved.Sage Therapeutics ©2024 MRC-PPD-00792 06/2024

Host: Jennifer Caudle, DO Guest: Rosanne Kho, MD To learn how Myfembree® (relugolix, estradiol, norethindrone acetate) could help address uterine fibroid-associated heavy menstrual bleeding or moderate to severe endometriosis pain in premenopausal women; listen to Dr. Jennifer Caudle and Dr. Rosanne Kho, Chair of the OB/GYN Department at the University of Arizona College of Medicine in Phoenix. Please scroll for Important Safety Information. Please see full Prescribing Information including BOXED WARNING here.

Host: Blake Zwerling, MD The Society of Family Planning and the Society of Maternal Fetal Medicine have released updated guidelines for medication abortion. Tune in as Dr. Blake Zwerling, Assistant Clinical Professor of Complex Family Planning, reviews these updates and shares how they can be used in clinical practice.

Guest: Christena Raines, NP Perinatal mood disorders are among the most common complications during pregnancy and immediately following delivery. So front line providers need to be able to initiate treatment. Perinatal Psychiatric Nurse Practitioner and Adjunct Professor of Psychiatry at UNC Chapel Hill, Christena Raines, discusses her session at the 26th Annual Nurse Practitioners in Women's Healthcare Conference and the importance of recognizing and treating perinatal mood disorders in our female patients.

Guest: Dawn Kimberly Hopkins, PhD, WHNP-BC Understanding the manifestations of polycystic ovary syndrome (PCOS) can help to identify this condition in women better. And though it's a common condition, some providers are unaware of how to diagnose it. Dig into the pathophysiology of PCOS with Dr. Dawn Kimberly Hopkins, Research Associate at the Henry Jackson Foundation in Bethesda, Maryland.

Guest: Genevieve Hofmann, NP Menopause can impact everyday life, and many women go untreated for their menopausal symptoms. To learn more about some of the complex issues surrounding menopause management, join Dr. Genevieve Hofmann, Women's Health Nurse Practitioner, Certified Menopause Clinician, and Assistant Professor of OB/GYN Health at the University of Colorado School of Medicine, who will be discussing these strategies at the 2023 Annual NPWH Women's Healthcare Conference.

Guest: Jennifer Herrmeyer, RN Approximately less than 30 percent of domestic violence patients will seek care for their injuries, so it's important for us to reach out to those in need. How can we be better at identifying and caring for these patients? Tune in to learn more with Ms. Jennifer Herrmeyer, Emergency Department Nurse at Hennepin Healthcare in Minneapolis, Minnesota.

Guest: Sadia Haider, MD, PhD After a historic year of legislation for abortion and contraception, there are still many questions surrounding patient care. Tune in as Dr. Sadia Haider, Interim Chair of OB-GYN at RUSH University and President Elect of the Society of Family Planning, discusses the research presented at the 2023 Society of Family Planning Annual Meeting.

Host: Charles Turck, PharmD, BCPS, BCCCP Guest: Emily M. Godfrey, MD, MPH A recent study presented at the 2023 ACOG Annual Clinical and Scientific Meeting examined patient perspectives on clinician communication regarding medication abortion during telemedicine versus in-clinic visits and found that patients prefer to receive abortion care via telemedicine. Learn more about the study's design and results with Dr. Charles Turck and Dr. Emily Godfrey, Professor of Family Medicine and Obstetrics and Gynecology at the University of Washington.

Guest: Mitchell D. Creinin, MD Dive into the research presented at the 2023 ACOG Annual Scientific and Clinical Meeting that found that the use of levonorgestrel 52-mg intrauterine device (IUD) in patients with heavy menstrual bleeding reduced blood loss by more than 90 percent over six months with Dr. Mitch Creinin, Professor in the Department of Obstetrics and Gynecology as well as the Director of the Complex Family Planning Fellowship at the University of California Davis Health.

Guest: Mitchell D. Creinin, MD While the use of levonorgestrel 52-mg intrauterine device (IUD) has been shown to reduce blood loss in patients with heavy menstrual bleeding, these same patients are at an increased likelihood of expelling the IUD. That's why it's important to set realistic expectations with patients, as Dr. Mitch Creinin from the University of California Davis Health explains.

Guest: Tiffany A. Moore Simas, MD, MPH, MEd, FACOG Host: Charles Turck, PharmD, BCPS, BCCCP New guidelines regarding the screening, diagnosis, and pharmacological treatment of perinatal mental health conditions as well as resources like in-depth toolkits and implementation guides are now available to help optimize the management of patients with perinatal mental health conditions. Find out how these tools can help you better address one of the most common complications of pregnancy with Dr. Charles Turck and Dr. Tiffany Moore Simas, the Chair of the Department of Obstetrics and Gynecology at UMass Chan Medical School who presented a few sessions focusing on this exact topic at the 2023 ACOG Annual Clinical and Scientific Meeting.

Guest: Tiffany A. Moore Simas, MD, MPH, MEd, FACOG According to a poster that was featured at the 2023 ACOG Annual Clinical and Scientific Meeting, only 75 percent of patients at UMass Chan Medical School were screened for perinatal mental health conditions, and of those screened, white patients were more likely to be connected with appropriate care and treatment than black or Hispanic patients. Dive deeper into the findings that underscore the importance of addressing disparities and inequities in perinatal depression care with Dr. Tiffany Moore Simas, Chair of the Department of Obstetrics and Gynecology at UMass Chan Medical School.

Host: Lee P. Shulman, MD, FACMG, FACOG Guest: Roberto Romero, MD, DMedSci Renowned international expert Dr. Roberto Romero joins Dr. Lee Shulman to walk us through maternal anti-fetal rejection. Find out about its pathophysiology, mechanisms of disease, approach to diagnosis, and potential treatment so that you can broaden your understanding and improve the care you provide.

Host: Jennifer Caudle, DO Guest: Tamera A. Paczos, MD, FACOG, FACP The utility of p16 and Ki-67 immunostaining in biopsies has helped lead to the development of dual staining in cytology specimens. So what do clinicians need to know about the dual stain cytology test? Take a deep dive into this topic as Dr. Jennifer Caudle is joined by Dr. Tamera A. Paczos, Vice President, Associate Chief Medical Officer with BioReference Laboratories. COBAS and CINTEC are trademarks of Roche.All other product names and trademarks are the property of their respective owners. 02/23

Host: Lee P. Shulman, MD, FACMG, FACOG Guest: Alexandra Benachi, MD, PhD Guest: Julien Zuber, MD, PhD Program Chairman:Roberto Romero, MD, DMedSciChief, Perinatology Research BranchDivision of Maternal-Fetal Medicine and ObstetricsDivision of Intramural ResearchNICHD/NIH/DHHSEditor-in-Chief for ObstetricsThe American Journal of Obstetrics and Gynecology There exists a long-standing controversy about drawing parallels between transplant and pregnancy immunology. Listen in as Drs. Alexandra Benachi, Julien Zuber, and Lee Shulman discuss why these considerations are so important for you and your colleagues, patients, and their families to understand. Discover how links between kidney transplantation and maternal anti-fetal rejection may impact your practice and spark new pathways in medicine.

Host: Jennifer Caudle, DO Guest: Diane M. Harper, MD, MPH, MS There are several testing methods available for cervical cancer screening, such as co-testing and primary HPV testing. So what are some of the most prominent benefits and limitations of these and other testing approaches? Joining Dr. Jennifer Caudle to break down the latest advancements in cervical cancer screening is Dr. Diane Harper, a Professor in the Departments of Family Medicine and Obstetrics and Gynecology at the University of Michigan.

Host: Lee P. Shulman, MD, FACMG, FACOG Guest: Masja de Haas, MD, PhD Program Chairman:Roberto Romero, MD, DMedSciChief, Perinatology Research BranchDivision of Maternal-Fetal Medicine and ObstetricsDivision of Intramural ResearchNICHD/NIH/DHHSEditor-in-Chief for ObstetricsThe American Journal of Obstetrics and Gynecology Neonatal alloimmune neutropenia (NAIN or NIN) is a neutrophil blood group antagonism similar to HDFN and FNAIT. Its presentation varies clinically and ranges from asymptomatic to severe manifestations such as sepsis and meningitis. Listen in as Drs. Masja de Haas and Lee Shulman discuss clinical clues that should catch your eye. Discover novel yet simple ways to be vigilant and make the right clinical calls.

HPV testing plays an important role in cervical cancer screening, but not every patient whose HPV-positive will develop cervical cancer. One option that can help us identify which HPV-positive patients are truly at risk is CINtec PLUS Cytology, an immunohistochemistry test that simultaneously detects p16 and Ki67 biomarker proteins. Learn more about how this dual staining technique works in this video.

Host: Lee P. Shulman, MD, FACMG, FACOG Guest: James B. Bussel, MD Program Chairman:Roberto Romero, MD, DMedSciChief, Perinatology Research BranchDivision of Maternal-Fetal Medicine and ObstetricsDivision of Intramural ResearchNICHD/NIH/DHHSEditor-in-Chief for ObstetricsThe American Journal of Obstetrics and Gynecology As the platelet equivalent of hemolytic disease of the fetus and newborn, fetal and neonatal alloimmune thrombocytopenia (FNAIT) is an uncommon yet complex and life-threatening bleeding disorder that results from incompatibility between mother and baby for platelet-specific antigens. Despite relatively normal platelet function, in the setting of severe thrombocytopenia, intracranial hemorrhage is a consequence. Drs. Shulman and Bussel discuss advances in management strategies and concrete steps you can take to lower the risk and stop the progression of this disorder in your patients.

Host: Lee P. Shulman, MD, FACMG, FACOG Guest: Linda Bradley, MD Join Drs. Linda Bradley and Lee Shulman as they discuss factors contributing to disparities in care for patients with endometriosis and/or uterine fibroids. They offer practical tips to overcome the disproportionate disease burden that especially impacts women of color. Cut through the noise to clearly hear each patient's voice. Your clinical impact may be profound.

Host: Lee P. Shulman, MD, FACMG, FACOG Guest: Kenneth J. Moise Jr., MD Program Chairman: Roberto Romero M.D. D.Med Sci.Chief, Perinatology Research BranchDivision of Maternal-Fetal Medicine and ObstetricsDivision of Intramural ResearchNICHD/NIH/DHHSEditor-in-Chief for ObstetricsThe American Journal of Obstetrics and Gynecology Are you taking the right steps to consistently ensure all of your patients at risk of alloimmune disorders of pregnancy, specifically HDFN, receive a helping hand plus timely and appropriate clinical care? Despite having considerable clinical consequences, this area of medicine is not fully understood by many clinicians. Drs. Shulman and Moise provide expert insight on red blood cell alloimmunization, highlighting essential pathophysiology and current and evolving management strategies. Join us to learn new ways to approach this complicated and rare clinical condition.

Host: Lee P. Shulman, MD, FACMG, FACOG Guest: Nanette F. Santoro, MD Tune out the noise and get to the heart of managing menopause and associated vasomotor symptoms. This program provides highlights from the 2022 American College of Obstetricians and Gynecologists Annual Clinical and Scientific Meeting. Join Drs. Nanette Santoro and Lee Shulman as they dive into the latest research, which could alter your current practice patterns and help your patients cool off.

Host: Ayman Al-Hendy, MD Despite its profound impact, endometriosis remains critically undermanaged. This program provides highlights from a live symposium at the annual meeting for obstetrics and gynecology professionals and is based on patient & provider surveys. Join Dr. Ayman Al-Hendy to explore management gaps, the role of GnRH antagonists in addressing deficits, and the latest research, which he presented with Drs. Andrea Lukes and Lee Shulman—you might just alter your current practice patterns.

Host: Jeffery D. Dunn, PharmD, MBA Guest: Gary M. Owens, MD Guest: Anita L. Nelson, MD Are you ready to see what is on the horizon to more effectively navigate vasomotor symptoms (VMS)? Join Drs. Dunn, Owens, and Nelson as they discuss highlights from a symposium held at AMCP 2022 featuring the latest data on the impact of menopause and evolving treatments options. They provide guidance, context, and recommendations for the medical management of VMS beyond estrogen. The nonhormonal treatment options that are currently being studied represent a new horizon for both patients and payers.

Host: Patty Cason, RN, MS, FNP-BC Guest: Joely Pritzker, RN, MS, FNP-C Are you ready to apply the latest counseling techniques to address the contraceptive revolution? Join nurse practitioners Patty Cason and Joely Pritzker as they briefly review the history of contraceptive counseling and then use case vignettes to illustrate how shared decision-making techniques will support the appropriate use of nonhormonal contraceptive options, such as the vaginal pH modulator (VPM). Participating in this activity will ensure that you are ready to effectively counsel patients on their many options so that each patient's reproductive and sexual health goals can be met.

Host: David J. Portman, MD Guest: Patty Cason, RN, MS, FNP-BC Guest: David L. Eisenberg, MD, MPH, FACOG Are you ready for the contraceptive revolution? Are you applying the latest information on contraceptive efficacy, recent clinical trial data, and sexual satisfaction when counseling your patients on contraceptive options? Join Dr. David Portman, Dr. David Eisenberg, and Ms. Patty Cason as they discuss the novel mechanisms of action of cutting-edge, non-hormonal contraceptive options, such as the vaginal pH modulator (VPM). Participating in this activity will ensure that you are prepared to discuss sexual and reproductive goals with your patients and confirm that your patients' goals are being met.

Host: Lee P. Shulman, MD, FACMG, FACOG Guest: Ayman Al-Hendy, MD Surgery has long been the default choice when managing uterine fibroids and endometriosis. However, over the past few years, reliable and durable medical interventions have emerged, notably GnRH antagonist therapy. Clinical trial data for GnRH antagonists highlight both their safety and efficacy for a broad demographic of patients. Join Drs. Lee Shulman and Ayman Al-Hendy as they discuss the “how” and the “why” of a paradigm shift that is occurring, changing our focus from surgery to first-line medical intervention for uterine fibroids and endometriosis.

Host: Lee P. Shulman, MD, FACMG, FACOG Guest: Andrea S. Lukes, MD, MHSc, FACOG By 50 years of age, 70% to 80% of women are affected by uterine fibroids, and nearly 10% of women are affected by endometriosis. Clinical trial data demonstrate that GnRH antagonist therapy can dramatically impact pain and bleeding and improve results across all EHP-30 domains. Join Drs. Lee Shulman and Andrea Lukes as they dive into these data and offer strategies to help you better incorporate patient-centric medical management for uterine fibroids and endometriosis into your clinical practice.

Guest: Peter Goadsby, MD, PhD, DSc Guest: Kathleen B. Mullin, MD Women with migraine have unique needs that often remain undermanaged. Have you taken a critical look at the standard of care and how current treatment strategies have recently shifted? Groundbreaking research on the calcitonin gene-related peptide (CGRP) pathway has led to the development of new medications that act on the specific cascade of inflammatory response associated with migraine. Also called gepants, the CGRP receptor antagonists confer clinical benefit to patients who seek better control of their migraines. Tune in to this Women's Health 2021 program to hear our experts, Drs. Peter Goadsby and Kathleen Mullin, discuss the diagnosis of migraine with a focus on the recent evolution of acute and preventive treatment strategies and the role of gepants. Are you doing all you can to ensure that your patients' needs are optimally addressed?

Host: Lee P. Shulman, MD, FACMG, FACOG Guest: Erica E. Marsh MD, MSCI, FACOG Hear from Dr. Erica Marsh and Dr. Lee Shulman as they discuss the burden, prevalence, and treatment of uterine fibroids and endometriosis and the disproportionate impact these conditions have on vulnerable populations. Learn how to prioritize early diagnosis and treatment to improve outcomes for your patients; as well as evaluating barriers to proper diagnosis and treatment Our experts offer strategies to guide discussions beyond surgical treatment approaches to include pharmacotherapeutic options such as GnRH agonists and new oral GnRH antagonists. Open communication with patients allows them to carefully consider symptom severity, risks, and fertility preferences to optimize treatment outcomes and patient satisfaction. Tune in to make sure that you're really doing all you can for your patients.

Host: Anita L. Nelson, MD In this Women's Health 2021 lecture, Dr. Anita Nelson discusses why uterine fibroids are such a high priority for both women and their clinicians. Listen in as she shares strategies to engage patients in discussions about their fibroid symptoms and their preferences for treatment. Dr. Nelson also evaluates the latest evidence on the mechanisms of action, safety, and efficacy of the newer class of therapies that are now available and can improve the quality of life for women with fibroids.

Host: Anita H. Clayton, MD Listen in as Dr. Anita Clayton takes us through the importance of screening for postpartum depression (PPD) and reaching an early diagnosis in the perinatal and postnatal stages of pregnancy. This Women's Health 2021 lecture also covers the exciting new agents that are targeted specifically for PPD. Find out how they compare to the traditional antidepressants and how they can improve the quality of life for your patients with PPD.

Host: Anita L. Nelson, MD How confident are you in determining which of your patients with endometriosis are suitable candidates for medical intervention? Do you ask about each patient's goals and preferences? Have you heard about the paradigm shift occurring in the medical management of endometriosis? While medical management of endometriosis is often a secondary consideration to surgery, it should often be the first line of treatment. Join Dr. Anita Nelson as she discusses long-standing and novel medical strategies for managing endometriosis. Find out how you can use shared decision-making strategies to help you provide more options to your patients. Join us and take an important first step that can improve outcomes and quality of life for your patients while enabling them to make educated decisions about their immediate and long-term treatment.

Host: Andrea Singer, MD, FACP, CCD Guest: Paul A. Anderson, MD Guest: Susan V. Bukata, MD, FAOA, FAAOS While there's growing awareness among orthopedic surgeons that osteoporosis is the underlying cause of fractures, there is often a disconnect between this recognition and action in the form of treatment to prevent subsequent fractures. In this discussion, Drs. Andrea Singer, Paul Anderson, and Susan Bukata address the pathophysiology of osteoporosis and the need to identify patients at risk for additional fractures. Osteoporosis treatment (including pharmacotherapy) can play a critical role in preventing future fractures, but physicians must first recognize that fracture is a sentinel event and treat it as a call to action.

Host: David L. Eisenberg, MD, MPH, FACOG Many women prefer to use a nonhormonal contraceptive. They also want the freedom to self-administer on demand and want assurances that the contraceptive is safe, effective, and has received FDA approval. One such contraceptive is a self-administered, hormone-free gel that functions as a vaginal pH modulator. Join Dr. David Eisenberg as he describes the evolution of this vaginal pH modulator and the clinical trials leading to FDA approval. Even more significant is patient acceptance, which was remarkably high for this contraceptive. In fact, approximately 9 out of 10 women participating in the clinical trials indicated they would continue using the vaginal pH modulator and also recommend this novel method to their friends.

Host: Brooke M. Faught, DNP, WHNP-BC,NCMP, IF Our patients express a number of misperceptions about combined hormonal non-LARC contraceptives such as the contraceptive patch, vaginal rings, and oral contraceptive pills. How well do you explain the advantages and disadvantages of these different options to your patients? How often have you prescribed what appeared to be a good contraceptive method for your patients only to have them be dissatisfied and become nonadherent? Join Dr. Brooke Faught in this Women's Health 2021 lecture as she tackles these issues and offers insights into how to discuss the full range of combined hormonal non-LARC contraceptive options with your patients using shared decision-making strategies. Remember, each patient's needs, goals, and cultural background are important factors in a patient-centric approach to the choice of contraception.

Guest: Gregory Pokrywka MD, FACP, FNLA, FASPC, NCMP Guest: Karol Watson, MD, PhD Join us to discover optimal ways to identify women at risk or with atherosclerotic cardiovascular disease (ASCVD). In this Women's Health 2021 lecture, our experts, Dr. Gregory Pokrywka and Dr. Karol Watson, dive deeper into evidence-based approaches to assess and manage ASCVD in women. They discuss topics from lifestyle modifications to recent clinical trial data on the use of omega-3 fatty acids for ASCVD event reduction.