Podcasts about Yale school

Revenge isn't just an emotional impulse—it's an addiction. Dr. Phil and James Kimmel, Jr., JD, break down its impact on the brain and how forgiveness rewires our chemistry for healing. Revenge feels like justice, but what if it's more like an addiction? Dr. Phil and James dive into the neuroscience behind revenge—how it hijacks our brain's pain and reward systems just like substance dependency. They explore how society reinforces these cycles, why letting go isn't weakness, and how forgiveness actually rewires the mind. Plus, Kimmel's “Non-Justice System” offers a fresh way to process grudges without fueling destruction. In Kimmel's latest groundbreaking book, The Science of Revenge: Understanding the World's Deadliest Addiction and How to Overcome It, unveils the unseen neurobiological forces behind our compulsive desires for retribution—an addiction that silently fuels violence and aggression in all its forms. James Kimmel, Jr., JD, is a lecturer in psychiatry at the Yale School of Medicine, a lawyer, and the founder and co-director of the Yale Collaborative for Motive Control Studies. A breakthrough scholar and expert on revenge, he first identified compulsive revenge seeking as an addiction and developed the behavioral addiction model of revenge as a public health approach for preventing and treating violence. He is the creator of The Nonjustice System https://nonjustice.org/ , the Miracle Court app https://www.miraclecourt.com/and https://SavingCain.org  for recovering from grievances and revenge desires and preventing mass violence. He maintains an active legal practice and speaking calendar and is the author of two other books on revenge: Suing for Peace: A Guide for Resolving Life's Conflicts and The Trial of Fallen Angels, a novel. Special thanks to our sponsors! Support the brands that support us! Visit them and let them know we sent you: Jase Medical: Get emergency antibiotics at https://Jase.com/  & use code PHIL for a discount. Kikoff: Build credit fast and get your first month for just a dollar at https://GetKikoff.com/phil/ today. Thanks to Kikoff for sponsoring us! Echo Water: Find your flow state. Visit https://echowater.com/PHIL/ & Use code PHIL for 10% off. MASA Chips: Visit: https://MASAChips.com/MERIT/ and use code MERIT for 25% off your first order. Balance of Nature: Go to https://balanceofnature.com/  or call 1.800.246.8751 and get this special offer by using Discount Code: “DRPHIL”. Get a FREE Fiber & Spice supplement, plus 35% OFF your first preferred set as a new Preferred Customer, with free shipping and our money-back guarantee. Start your journey with Balance of Nature.   Preserve Gold: Visit: https://drphilgold.com/ Get a FREE precious metals guide that contains essential information on how to help protect your accounts. Text “DRPHIL” to 50505 to claim this exclusive offer from Preserve Gold today.

LifeBlood: We talked about the science of revenge, what it is and why it's so attractive, James' harrowing backstory that led him to this work, how and why forgiveness is the key to avoiding and or stopping this addiction from taking hold, and who this desire will ultimately destroy, with Dr. James Kimmel, Jr., JD, a lecturer in psychiatry at the Yale School of Medicine, and author.  Listen to learn how to effectively let go of our desire for revenge and retribution! You can learn more about James at JamesKimmelJr.com, X, and Linkedin. Get your copy of The Science of Revenge here: https://amzn.to/3DwIaSf  Thanks, as always for listening! If you got some value and enjoyed the show, please leave us a review here: ​​https://ratethispodcast.com/lifebloodpodcast You can learn more about us at LifeBlood.Live, Twitter, LinkedIn, Instagram, YouTube and Facebook or you'd like to be a guest on the show, contact us at contact@LifeBlood.Live.  Stay up to date by getting our monthly updates. Want to say “Thanks!” You can buy us a cup of coffee. https://www.buymeacoffee.com/lifeblood Copyright LifeBlood 2025.

In this episode of the Intelligent Medicine podcast, Dr. Ronald Hoffman hosts Dr. James Kimmel, a lecturer in psychiatry at the Yale School of Medicine, to discuss the psychology and science behind revenge. Dr. Kimmel explains how revenge operates similarly to an addiction in the brain, triggering the same pleasure and reward circuits. He recounts his own traumatic experience with bullying and how it led him to understand the destructive nature of revenge. The discussion covers the implications for criminal justice, the role of social media in exacerbating revenge behaviors, and practical strategies for managing revenge cravings, including the potential benefits of forgiveness. Dr. Kimmel's new book, "The Science of Revenge," explores these themes and offers insights into breaking free from the cycle of retribution.

In this episode of the Intelligent Medicine podcast, Dr. Ronald Hoffman hosts Dr. James Kimmel, a lecturer in psychiatry at the Yale School of Medicine, to discuss the psychology and science behind revenge. Dr. Kimmel explains how revenge operates similarly to an addiction in the brain, triggering the same pleasure and reward circuits. He recounts his own traumatic experience with bullying and how it led him to understand the destructive nature of revenge. The discussion covers the implications for criminal justice, the role of social media in exacerbating revenge behaviors, and practical strategies for managing revenge cravings, including the potential benefits of forgiveness. Dr. Kimmel's new book, "The Science of Revenge," explores these themes and offers insights into breaking free from the cycle of retribution.

Is it healthier to be short or tall? Not that you can do much about it – but this episode begins by exploring some interesting health differences between the tall and the short. https://www.bbc.com/news/health-32117018 All of us have had the urge to get revenge on someone for something they did to us. Seeking revenge is a very powerful feeling that many people cannot control. Yet, more often than not, getting revenge is not that satisfying and you often end up regretting it - road rage being the perfect example. James Kimmel, Jr. joins me to help us understand why feelings of revenge are hard to tame and what you can do when you feel revenge to de-escalate the situation. James is a lecturer in psychiatry at the Yale School of Medicine, a lawyer, and the founder and co-director of the Yale Collaborative for Motive Control Studies. He is author of a book called The Science of Revenge: Understanding the World's Deadliest Addiction--and How to Overcome It (https://amzn.to/3SPx8v2). Fear of snakes is very common. Lots of people hate them - but the fact is they are fascinating creatures which have adapted to survive everywhere on earth (except one place). There are snakes that lay eggs and snakes who have live births. There are snakes that eat every day and snakes that eat only once a year. And just how dangerous are they? That depends. Listen as I talk with Stephen S. Hall, a science writer whose work has appeared in the New York Times Magazine, The Atlantic Monthly, National Geographic, Wired, Science, and more. He is author of the book Slither: How Nature's Most Maligned Creatures Illuminate Our World (https://amzn.to/44OPyne). People like to put their best foot forward on social media and often they will brag about a promotion or romance or post a photo of their new car or boat. But how is that actually received by the people who see it? Listen as I reveal what people think about this sort of “humble bragging.” https://www.sciencedaily.com/releases/2015/05/150512104037.htm PLEASE SUPPORT OUR SPONSORS!!! MINT MOBILE: Ditch overpriced wireless and get 3 months of premium wireless service from Mint Mobile for 15 bucks a month at ⁠⁠⁠⁠⁠⁠https://MintMobile.com/something⁠⁠⁠⁠⁠⁠ ! FACTOR: Eat smart with Factor! Get 50% off at ⁠⁠⁠⁠⁠⁠⁠⁠https://FactorMeals.com/something50off⁠⁠⁠⁠⁠⁠⁠⁠ TIMELINE: Get 10% off your order of Mitopure!  Go to ⁠⁠⁠⁠⁠⁠⁠⁠https://Timeline.com/SOMETHING⁠⁠⁠⁠⁠⁠⁠⁠ ROCKET MONEY: Cancel your unwanted subscriptions and reach your financial goals faster! Go to ⁠⁠⁠https://RocketMoney.com/SOMETHING⁠⁠⁠ QUINCE: Elevate your shopping with Quince! Go to ⁠⁠⁠⁠⁠⁠⁠⁠https://Quince.com/sysk⁠⁠⁠⁠⁠⁠⁠⁠ for free shipping on your order and 365 day returns! INDEED: Get a $75 sponsored job credit to get your jobs more visibility at ⁠⁠⁠⁠⁠⁠⁠⁠https://Indeed.com/SOMETHING⁠⁠⁠⁠⁠⁠⁠⁠ right now! DELL: The power of Dell AI with Intel inside is transforming the world of pro sports! For the players and the fans who are there for every game. See how Dell Technologies with Intel inside can help find your advantage, and power your wins at ⁠⁠⁠⁠https://Dell.com/Wins⁠⁠⁠⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices

Revenge sounds like a good idea sometimes. Whether you want to get back at an ex or you want to hurt a coworker who wronged you, there's a reason why you might fantasize about getting even. It has to do with the way your brain works. Today's guest, James Kimmel Jr., is a researcher at Yale School of Medicine and the author of The Science of Revenge. He'll discuss how revenge becomes addictive and why you shouldn't entertain the idea. Some of the things we talk about today are: Why revenge is a natural human craving and how it activates your brain's addiction pathways How to recognize and break free from toxic revenge cycles The surprising science behind forgiveness and why it's better for you than revenge A powerful mental exercise to help you move beyond resentment How letting go of revenge can help you build resilience and mental strength Want more tips for building mental strength? Subscribe to ⁠Mentally Stronger Premium⁠ and get weekly AMA episodes and monthly bonuses to help you grow mentally stronger! Links & Resources JamesKimmelJr.com The Science of Revenge Episode 182 — The Science of Forgiveness Connect with the Show Buy Amy's ⁠⁠books on mental strength⁠⁠ Connect with Amy on Instagram — ⁠⁠@AmyMorinAuthor⁠⁠ ⁠AmyMorinLCSW.com ⁠ Sponsors OneSkin — Get 15% off OneSkin with the code STRONGER at ⁠⁠⁠⁠https://www.oneskin.co/⁠⁠⁠⁠ #oneskinpod Calm — Get 40% off a Calm Premium Subscription at ⁠⁠⁠⁠calm.com/STRONGER⁠⁠⁠⁠ AirDoctor — Head to ⁠⁠⁠⁠AirDoctorPro.com⁠⁠⁠⁠ and use promo code STRONGER to get UP TO $300 off today! Shopify — Sign up for your one-dollar-per-month trial period at ⁠⁠⁠⁠Shopify.com/mentallystronger⁠⁠⁠⁠ ZocDoc - Go to Zocdoc.com/STRONGER to find and instantly book a top-rated doctor today! Mentally Strong — Sign up for your free 7-day trial at MentallyStrong.Downpait.Ai⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. Anne Zink, Former ASTHO President and a Senior Clinical Fellow at the Yale School of Public Health, describes the 100 Miles in May challenge; Anna Bradley, ASTHO Senior Analyst for Public Health Infrastructure and Performance Improvement, discusses how to better gather community engagement metrics; an ASTHO webinar on Wednesday, May 28th at 1 p.m. ET will focus on administrative preparedness for public health emergencies; and your next great hire could be found at publichealthcareers.org. 100 Miles In May Web Page ASTHO Blog Article: Meaningful Measures for Community Engagement in Public Health ASTHO Webinar: Strengthening Administrative Preparedness in Public Health Agencies PublicHealthCareers.org  

Chime In, Send Us a Text Message!Episode Overview:In this powerful episode of the Know Stroke Podcast, we're diving into a bold and urgent mission: educating one million kids on how to recognize the signs of stroke.We sit down with the team behind this ambitious initiative—Sevaro CEO Raj Narula and Yale School of Medicine's Rebecca DiBiase and Samuel Namian—to explore how they're bringing stroke education into schools across the country.Together, they're combining clinical expertise, innovative delivery models, and a shared belief that kids can play a pivotal role in saving lives.

Revenge, why do we want to get revenge so bad? And where does that urge come from? And how do we go from wanting to get revenge to being able to forgive someone or others? James Kimmel Jr., Yale lecturer and co-founder of the Yale Collaborative for Motive Studies, is on Getting Better this week to teach us just that. James gives us insight into the psychology of these complex emotions, the parts of the brain affected, and what research, studies and science shows us about forgiveness. James Kimmel, Jr., JD, is a lecturer in psychiatry at the Yale School of Medicine, the founder and co-director of the Yale Collaborative for Motive Control Studies, and a researcher, lawyer, and novelist who focuses on neuroscience, psychology, revenge, addiction, forgiveness, and violence. A breakthrough scholar and expert on revenge and forgiveness, he first identified compulsive revenge seeking as an addiction and first developed the behavioral addiction model of revenge and the brain disease model of revenge addiction as public health approaches for preventing and treating violence. More can be found on his personal website, www.jameskimmeljr.com. Full Video Episodes now available on YouTube. Not A Phase. Trans Lifeline Follow us on Instagram @gettingbetterwithjvn Jonathan on Instagram @jvn Senior Producer, Chris McClure Producer, Editor & Engineer is Nathanael McClure Production support from Julie Carrillo, Anne Currie, and Chad Hall Our theme music is also composed by Nathanael McClure. Curious about bringing your brand to life on the show? Email podcastadsales@sonymusic.com. Learn more about your ad choices. Visit podcastchoices.com/adchoices

After todays episode, head on over to @therapybookspodcast to learn about the latest giveaway. *Information shared on this podcast is for informational and educational purposes only. In this weeks episode, Jessica Fowler speaks with Christina Cipriano, PhD. about her book Be Unapologetically Impatient: The Mindset Required to Change the Way We Do Things. Dr. Cipriano, shares ways to work toward inclusion with her own stories and the science on how to change the way we do things. Highlights from this episode: 3:19: Dr. Cipriano shares about an experience that brought to light the idea of challenging the status quo and how to impact change. 3:44: Dr. Cipriano shares about her life that lead to this book and some of her personal experience specifically around disability. 7:52 Dr. Cipriano shares an example of how to engage people and how to pull them in instead of calling them out. 8:58: We discussed this idea of "waiting to fail" that often is needed prior to kids receiving services. 14:11: We discuss the idea of knowing yourself when you have interactions while advocating for your kids. 18:24: Dr. Cipriano shares what community members can do to be more inclusive. 24:27: Dr. Cipriano shares who the book is for. About the author: Christina Cipriano, Ph.D., is an associate professor of Applied Developmental and Educational Psychology at the Yale Child Study in the Yale School of Medicine and Director of the Education Collaboratory at Yale University. An award-winning scholar and internationally regarded expert in the science of learning and development, Dr. Cipriano received her Ph.D. from Boston College, her Ed.M. from the Harvard Graduate School of Education and undergraduate degree from Hofstra University. A prolific public scholar, educator, and speaker, Chris brings her positionality as a first-generation high school graduate and mother of four children to her science and work.  

Welcome to Notable Leaders Radio! I'm Belinda Pruyne, in this milestone 100th episode, I'm celebrating the incredible guests who've shared their wisdom, courage, and vulnerable stories over the years.  In today's episode, we discuss: Discover the real journeys behind "overnight success" stories—Because you'll see that even the most accomplished leaders face setbacks and internal challenges, giving you permission to honor your own slow burn to success rather than compare yourself to unrealistic narratives. Those “overnight successes” actually take 15 years of hard work and pushing through whatever is in your way. Learn about finding and using your unique voice, especially in male-dominated industries (Ivy Slater's, Vice Admiral Sandra Stosz's, Michelle Russo's, Amy Conway-Hatcher's, Dr Mary O'Connor's, stories)—If you're struggling to stand out or be heard, their insights will help you leverage your strengths in any challenging environment.  Hear diverse stories of joy, resilience, and strategic risk-taking—so you can build more joy, clarity, and growth into your own work, borrowing from actionable wisdom shared by a variety of leaders, from corporate executives to entertainers/authors to military figures, and the list goes on. See the power of “Being More You, Not Faux You” in tough situations (Amanda Hawkins' story)—You'll realize that authenticity isn't just a nice idea, but a winning strategy for building trust and influence with even the most senior decision-makers. Take away unique mindsets like architecting a life by design (Chad Lefebvre) versus a life by default—As a way to challenge accepted norms and intentionally create a fulfilling path, instead of just accepting what you're given. Understand how personal experiences outside of business (from dance to the board room, riding instructor to corporate executive…) can shape leadership strengths—Meaning you can tap into your own life story and skills for professional advantage, not just traditional credentials. RESOURCES: SHOW Links: Ivy Slater   Discovering Your Voice - https://belindapruyne.com/episode2  Book -From the Barre to the Boardroom -  https://amzn.to/3FeRhrt  Amanda Hawkins  Be More You Not Faux You - https://belindapruyne.com/episode3  Maddie Brown   Honoring All That Matters To You https://belindapruyne.com/episode4  Belinda Pruyne  Differentiating Good and Great Leaders https://belindapruyne.com/episode5  Honey & Blaine Parker  Making Success Fun - https://belindapruyne.com/episode6  Amy Herman   The Art of Perception - https://belindapruyne.com/episode12  Book - Visual Intelligence: Harnessing the Power of Observation to Transform Your Professional Life, enhance Communication skills, and Discover Hidden Potential in Everyday Situations https://amzn.to/4k13zTB Book - Fixed: How to Perfect the Fine Art of Problem Solving https://amzn.to/4k3vMZQ Book -smART: Use Your Eyes to Boost Your Brain Intelligence (adapted from the NY Times bestseller Visual Intelligence) https://amzn.to/4k3vMZQ Beverly Wallace  Trust Your Inner Voice - https://belindapruyne.com/episode7  Admiral Sandra Stocz  Women in Leadership - https://belindapruyne.com/episode21  Jayne Atkinson   Staying True to Your Convictions https://belindapruyne.com/episode23  Shalini Goval-Pai  Dream Big and Persevere - https://belindapruyne.com/episode36  Carlos Williams   Powerful Lessons - https://belindapruyne.com/episode43  Mary O'Connor   If Not Me Then Who - https://belindapruyne.com/episode44  Taylor Jacobson   Don't Let Shame Dictate What You Can Do Or Achieve https://belindapruyne.com/episode90  Andrea Sampson   Grace and Growth: Embrace Your Story and Find Self-Compassion - https://belindapruyne.com/episode92  Gui Costin   Words Matter: How Gui Costin Built a Culture of Kindness and Excellence https://belindapruyne.pages.ontraport.net/belindapruyne.com  David Steele  The Recipe for Sustainable Happiness and Business Success - https://belindapruyne.com/episode99steele  Judy Winslow   Embrace your inner weirdo! https://belindapruyne.com/episode97winslow Chad LeFevre   Architect a life by design vs tolerating a life by default https://belindapruyne.com/episode98Lefevre    Belinda's Bio: Belinda is a sought-after Leadership Advisor, Coach, Consultant and Keynote speaker and a leading authority in guiding global executives, professionals and small business owners to become today's highly respected leaders. As the Founder of BelindaPruyne.com, Belinda works with such organizations as IBM, Booz Allen Hamilton, BBDO, The BAM Connection, Hilton, Leidos, Yale School of Medicine, Landis, and the Discovery Channel. Most recently, she redesigned two global internal advertising agencies for Cella, a leader in creative staffing and consulting. She is a founding C-suite and executive management coach for Chief, the fastest-growing executive women's network. Since 2020, Belinda has delivered more than 72 interviews with top-level executives and business leaders who share their inner journey to success; letting you know the truth of what it took to achieve their success in her Notable Leaders Radio podcast. She gained a wealth of expertise in the client services industry as Executive Vice President, Global Director of Creative Management at Grey Advertising, managing 500 people around the globe. With over 20+ years of leadership development experience, she brings industry-wide recognition to the executives and companies she works with. Whether a startup, turnaround, acquisition, or global corporation, executives and companies continue to turn to Pruyne for strategic and impactful solutions in a rapidly shifting economy and marketplace.   Website: Belindapruyne.com Email Address: hello@belindapruyne.com LinkedIn: https://www.linkedin.com/in/belindapruyne  Facebook: https://www.facebook.com/NotableLeadersNetwork.BelindaPruyne/  Twitter: https://twitter.com/belindapruyne?lang=en  Instagram: https://www.instagram.com/belindapruyne/ 

Today on Mea Culpa, I'm joined by Yale Professor Jeffrey Sonnenfeld, a leading expert on leadership, corporate ethics, and government accountability. He's the Senior Associate Dean at the Yale School of Management, organizer of the CEO Summit, and author of “Firing Back,” where he wrote about Donald Trump. After spending a weekend with him at Yale, I knew I had to bring him on the show. We break down the dangerous mix of spectacle and power behind Trump's second-term agenda, from chaotic trade wars and hollow cabinet picks to the politicization of education and dismantling of oversight. Professor Sonnenfeld offers chilling insights into how Trump's reality-TV ethos is shaping public policy, why authoritarianism feeds on chaos and loyalty, and what business leaders and civil society must do now to defend our democracy. Thanks to our sponsors: Hims: Start your free online visit today at Hims.com/COHEN. Graza: Take your food to the next level with Graza Olive Oil. Visit https://graza.co/COHEN and use promo code COHEN  today for 10% off of TRIO! Wild Alaskan: Go to https://wildalaskan.com/COHEN for $35 OFF your first box of premium, wild-caught seafood. Subscribe to Michael's NEW Youtube Channel: https://www.youtube.com/@TheMichaelCohenShow Join us on Patreon: https://www.patreon.com/PoliticalBeatdown Add the Mea Culpa podcast feed: https://www.meidastouch.com/tag/mea-culpa-with-michael-cohen Add the Political Beatdown podcast feed: https://www.meidastouch.com/tag/political-beatdown Learn more about your ad choices. Visit megaphone.fm/adchoices

On this episode, we visit the Massachusetts Audubon Society (Mass Audubon). While there, we examine some objects related to the early history of the Society from Membership Specialist, Emily Gray. MHS Chief Historian Peter Drummey and Bancroft Poor, Chief Operating Officer and Chief Financial Officer at Mass Audubon, tell us about the Society's formation as an advocacy group at the turn of the twentieth century and how its goals have changed over time.  Learn more about episode objects here: https://www.masshist.org/podcast/season-4-episode-6-Mass-Audubon  Email us at podcast@masshist.org. Episode Special Guests: Bancroft Poor serves as Chief Operating Officer and Chief Financial Officer for Mass Audubon. In these roles, he is in charge of information technology, human resources, capital assets and planning, and financial functions, including budget preparation and monitoring, annual audit and tax preparation, insurance, contracting, investment liaison, and banking. He is a member of the senior management team and one of the primary staff contacts with the Board of Directors, serving as staff liaison to the Board Administration/Finance, Audit, and Investment Committees. In addition, he manages Mass Audubon's Belize program and works extensively on Mass Audubon's internal climate change and energy conservation initiatives. Bancroft Poor has been an employee of Mass Audubon since 1984. He is a graduate of Harvard College and holds a master's degree in Public and Private Management from the Yale School of Management. Emily Gray is a Membership Specialist with Mass Audubon. This episode uses materials from: The Bond (Instrumental) by Chad Crouch (Attribution-NonCommercial 4.0 International)        Psychic by Dominic Giam of Ketsa Music (licensed under a commercial non-exclusive license by the Massachusetts Historical Society through Ketsa.uk)        Curious Nature by Dominic Giam of Ketsa Music (licensed under a commercial non-exclusive license by the Massachusetts Historical Society through Ketsa.uk)

Howie and Harlan are joined by James Dodington, a Yale pediatric emergency medicine physician and an expert in community-based violence prevention. Harlan reports on the remarkable financial results and sometimes questionable science of Hims & Hers Health; Howie discusses UnitedHealthcare's faltering stock price in the face of anger over aggressive care denial and a lawsuit from shareholders. Links: Oscar Health and Hims & Hers “Oscar Health Profits Eclipse $275 Million As Obamacare Enrollment Soars” “Hims & Hers Health Revenue Jumps, But Outlook Disappoints” “Hims & Hers' Q1 revenue doubles to $586M, boosted by growth in weight loss business” “Novo Nordisk to sell Wegovy through telehealth firms to cash-paying US customers” “They Wanted a Quick Fix for Hair Loss. Instead, These Young Men Got Sick.” “EU drugs regulator confirms suicidal thoughts as side effect of hair loss drug” “Measures to minimise risk of suicidal thoughts with finasteride and dutasteride medicines” “FDA alerts health care providers, compounders and consumers of potential risks associated with compounded topical finasteride products” James Dodington Health & Veritas Episode 81: Joseph Sakran: Confronting Gun Violence Health & Veritas Episode 77: Megan Ranney: What's Next for Public Health? “Children and teens are more likely to die by guns than anything else” “U.S. Surgeon General Issues Advisory on the Public Health Crisis of Firearm Violence in the United States” “New Report Highlights U.S. 2022 Gun-Related Deaths: Firearms Remain Leading Cause of Death for Children and Teens, and Disproportionately Affect People of Color” James Dodington: “Rural Versus Urban Hospitalizations for Firearm Injuries in Children and Adolescents” “Disparities in Pediatric Mental and Behavioral Health Conditions” “Special Report: Dean Megan Ranney Brings a Public Health Approach to the Country's Gun Violence Epidemic” “Gun Violence Is a Public Health Crisis—But Hospital-based Intervention Programs Can Help Break the Cycle” “Implementation of an emerging hospital-based violence intervention program: a multimethod study” UCSF Wraparound Project: The Public Health Model for Violence Prevention “Just Listen” Firearm Injury Prevention at the Yale School of Public Health “11 Years After Sandy Hook—A New Path Toward Healing and Hope” Nelba Márquez-Greene's Shared Humanity Podcast 4-CT:Violence Intervention and Prevention “Cash Pilot Targets Violence Victims” “How unrestricted cash aid is transforming violence intervention in Connecticut” “Yale undergraduate team takes first place in national health policy competition” UnitedHealthcare “UnitedHealth CEO Is Out, Sending Shares Plummeting” “UnitedHealthcare sued by shareholders over reaction to CEO's killing” UnitedHealth Shareholder Lawsuit “UnitedHealth's string of setbacks, from exec murder to cyber attack” “Zepbound Patients Fear Losing Coverage After CVS Deal for Wegovy” “Zepbound beats Wegovy for weight loss in first head-to-head trial of blockbuster drugs”  

Howie and Harlan are joined by James Dodington, a Yale pediatric emergency medicine physician and an expert in community-based violence prevention. Harlan reports on the remarkable financial results and sometimes questionable science of Hims & Hers Health; Howie discusses UnitedHealthcare's faltering stock price in the face of anger over aggressive care denial and a lawsuit from shareholders. Links: Oscar Health and Hims & Hers “Oscar Health Profits Eclipse $275 Million As Obamacare Enrollment Soars” “Hims & Hers Health Revenue Jumps, But Outlook Disappoints” “Hims & Hers' Q1 revenue doubles to $586M, boosted by growth in weight loss business” “Novo Nordisk to sell Wegovy through telehealth firms to cash-paying US customers” “They Wanted a Quick Fix for Hair Loss. Instead, These Young Men Got Sick.” “EU drugs regulator confirms suicidal thoughts as side effect of hair loss drug” “Measures to minimise risk of suicidal thoughts with finasteride and dutasteride medicines” “FDA alerts health care providers, compounders and consumers of potential risks associated with compounded topical finasteride products” James Dodington Health & Veritas Episode 81: Joseph Sakran: Confronting Gun Violence Health & Veritas Episode 77: Megan Ranney: What's Next for Public Health? “Children and teens are more likely to die by guns than anything else” “U.S. Surgeon General Issues Advisory on the Public Health Crisis of Firearm Violence in the United States” “New Report Highlights U.S. 2022 Gun-Related Deaths: Firearms Remain Leading Cause of Death for Children and Teens, and Disproportionately Affect People of Color” James Dodington: “Rural Versus Urban Hospitalizations for Firearm Injuries in Children and Adolescents” “Disparities in Pediatric Mental and Behavioral Health Conditions” “Special Report: Dean Megan Ranney Brings a Public Health Approach to the Country's Gun Violence Epidemic” “Gun Violence Is a Public Health Crisis—But Hospital-based Intervention Programs Can Help Break the Cycle” “Implementation of an emerging hospital-based violence intervention program: a multimethod study” UCSF Wraparound Project: The Public Health Model for Violence Prevention “Just Listen” Firearm Injury Prevention at the Yale School of Public Health “11 Years After Sandy Hook—A New Path Toward Healing and Hope” Nelba Márquez-Greene's Shared Humanity Podcast 4-CT:Violence Intervention and Prevention “Cash Pilot Targets Violence Victims” “How unrestricted cash aid is transforming violence intervention in Connecticut” “Yale undergraduate team takes first place in national health policy competition” UnitedHealthcare “UnitedHealth CEO Is Out, Sending Shares Plummeting” “UnitedHealthcare sued by shareholders over reaction to CEO's killing” UnitedHealth Shareholder Lawsuit “UnitedHealth's string of setbacks, from exec murder to cyber attack” “Zepbound Patients Fear Losing Coverage After CVS Deal for Wegovy” “Zepbound beats Wegovy for weight loss in first head-to-head trial of blockbuster drugs”  

Ep.245 Natia Lemay (b. 1985 in Toronto, Ontario) was raised in Winnipeg, Manitoba, Canada, and is based in Toronto, Ontario, Canada. Her Interdisciplinary autoethnographic practice reflects her lived experience. Through personal stories, she interrogates the intersections between the mind, the body, and space to understand how these experiences relate to a broader cultural context. Natia Lemay has exhibited widely throughout North America. The artist was selected for the 2024 Fountainhead residency in Miami and the 2022 Royal Drawing School Residency in Dumfries, Scotland. She was awarded the National Trust Prize at Expo Chicago 2024, with her work acquired by High Museum in Atlanta in addition to being collected by the Art Gallery of Ontario, The Minneapolis Institute of Art, The Minnesota Museum of American Art, The North Dakota Museum of Art and The Montclair Museum of Art. She received her BFA from Ontario College of Art and Design in 2021 with a minor in Social Sciences and her MFA from Yale School of Art in 2023. Photo Credit is Gesi Schilling: Fountainhead Artist Residency Artist https://www.natialemay.com/ Whitehot Magazine https://whitehotmagazine.com/articles/her-first-nyc-solo-show/5792 Fountainhead Arts https://www.fountainheadarts.org/fhtv/artists/natia-lemay Juxatpoz https://www.juxtapoz.com/news/magazine/features/natia-lemay-the-act-of-being-seen/ Perrotin https://www.perrotin.com/artists/natia_lemay/1335#biography Galerie Nicolas Robert https://www.gallerynicolasrobert.com/natia-lemay Hyperallergic https://hyperallergic.com/851029/miami-fountainhead-residency-2024-selected-artists/ Ocula https://ocula.com/art-galleries/wilding-cran-gallery/artworks/natia-lemay/these-strange-girls-will-radiate-in-our-darkness/ Culture Type https://www.culturetype.com/tag/natia-lemay/ New American Paintings https://www.newamericanpaintings.com/artists/natia-lemay

Today, on Notable Leaders' Radio, I speak with David Steele, Founder + CEO of One Wealth Advisors and co-founder and Executive Chairman of Flour + Water Hospitality Group He highlights how applying the principles of service, goal-setting, and valuing people has shaped his journey from financial planning to building successful restaurant groups and supporting arts organizations. In today's episode, we discuss: True business success is rooted in serving others, not just making profits, because when work benefits others, it leads to deeper happiness and long-lasting impact, meaning you can feel good about making a difference while growing your business. Skills and principles are transferable from one industry to another, as David demonstrates by applying the same collaborative and organizational strategies across finance, food, and the arts, so you're not stuck on one path and can reinvent yourself in new fields with confidence. Pivotal life changes often start with self-awareness and honesty about dissatisfaction, like David's shift from being a successful stockbroker to a more fulfilling (but initially less lucrative) fee-based financial planning career. The lesson? It's okay, and sometimes essential, to pivot, especially if your values aren't being met. Caring for your team's well-being, even at a short-term cost, pays off through loyalty, retention, and greater future success, as shown by David's choice to keep his executive team during tough times, so you can build a lasting, supportive company culture.   Guest Bio David Steele, Founder + CEO of One Wealth Advisors and co-founder and Executive Chairman of Flour + Water Hospitality Group My primary role is as the co-founder and CEO of One Wealth Advisors, where we help people simplify their lives and achieve financial goals through Financial Life Planning. I am also the co-founder and Executive Chairman of Flour + Water Hospitality Group and the co-founder and Managing Partner of Great Gold Hospitality Group. Additionally, I bring extensive expertise and a range of resources to small business consulting, primarily in, but not limited to, the hospitality space. Alongside my teams, we support clients in various aspects of business development and operations to help them achieve their goals and vision. The culinary, health, arts, and entertainment worlds are particularly important to me, as reflected in my advisory roles with Noise Pop, Brilliant Corners, Rad Restaurant Group and Folk Studios. While my background may suggest diverse interests, everything I do follows a consistent, disciplined approach: working collaboratively with partners and team members, setting clear goals, developing and executing strategic plans to achieve those goals, and continually monitoring results to ensure success.   Website/Social Links https://davidsteele.xyz/ https://www.linkedin.com/in/david-steele-76088a?   Belinda's Bio: Belinda Pruyne is a renowned Leadership Advisor, Executive Coach, Consultant, and Keynote Speaker recognized for her ability to transform executives, professionals, and small business owners into highly respected, influential leaders. As the Founder of BelindaPruyne.com, she partners with top-tier organizations, including IBM, Booz Allen Hamilton, BBDO, Hilton, Leidos, Yale School of Medicine, Landis, Discovery Channel, and the Portland Trail Blazers. Recently, she led the redesign of two global internal advertising agencies for Cella, a leader in creative staffing and consulting. She is also a founding C-suite and executive management coach for Chief, the fastest-growing executive women's network. A thought leader in leadership development, Belinda is the creator and host of the Notable Leaders Radio podcast, where she has conducted 95+ interviews with top executives and business leaders, revealing the untold stories behind their success. Previously, as Executive Vice President, Global Director of Creative Management at Grey Advertising, she oversaw a global team of 500 professionals, gaining deep expertise in client services and executive leadership. With 25+ years of experience, Belinda is a trusted advisor to startups, turnarounds, acquisitions, and Fortune 500 companies, delivering strategic, high-impact solutions in today's fast-evolving business landscape.   Website: Belindapruyne.com Email Address: hello@belindapruyne.com LinkedIn: https://www.linkedin.com/in/belindapruyne Facebook: https://www.facebook.com/NotableLeadersNetwork.BelindaPruyne/ Twitter: https://twitter.com/belindapruyne?lang=en Instagram: https://www.instagram.com/belindapruyne/                  

Antimicrobial resistance is a rising global threat. When these become ineffective, infections can become difficult or impossible to treat, leading to an increase in the spread and severity of disease. In a new study, published in Nature Medicine, a team of researchers at the Center for Phage Biology and Therapy at Yale discovered a novel approach that may revolutionize the fight against antimicrobial resistance. In the study, the research team investigated the use of phage therapy—the use of viruses, or phages, to target and kill bacteria—to help patients with cystic fibrosis, a disease in which antimicrobial resistance is a significant issue. The team pioneered a strategy to select phages that not only kill bacteria that cause infections but also weaken surviving bacteria to become less virulent or less resistant to antibiotics. Joining me today to discuss phage therapy and their research is Jon Koff, MD, Dr. Koff is an associate professor in Yale School of Medicine's Section of Pulmonary, Critical Care, and Sleep Medicine and medical director of the Center for Phage Biology and Therapy.   Check out the paper: Phage Therapy May Treat Drug Resistance in Patients With Cystic Fibrosis, Study Finds   Watch the video version at Outbreak News TV

Send us a textDivorce hits men particularly hard, doubling their suicide risk while offering them fewer support resources than women typically receive. Dr. Eran Magen, Assistant Clinical Professor at Yale School of Medicine, draws from both professional expertise and personal experience to address this crisis through his work at DivorcingDads.org.The conversation explores why men struggle so profoundly after divorce - often isolating themselves rather than seeking support, feeling like failures, and facing challenging custody situations. Dr. Magen breaks down his comprehensive approach built on four essential pillars: navigating legal matters (especially custody arrangements), developing effective co-parenting strategies, strengthening practical parenting skills, and rebuilding a fulfilling personal life.We dive deep into the complexities of dating after divorce when children are involved. When should you start dating again? How do you introduce new partners to your children? What conversations should you have with kids of different ages? Dr. Magen offers thoughtful, practical guidance grounded in child development and relationship psychology.Support the showThanks for listening!Check out this site for everthing to know about women's pleasure including video tutorials and great suggestions for bedroom time!!https://for-goodness-sake-omgyes.sjv.io/c/5059274/1463336/17315Take the happiness quiz from Oprah and Arthur Brooks here: https://arthurbrooks.com/buildNEW: Subscribe monthly: https://www.buzzsprout.com/1805181/support Email questions/comments/feeback to tamara@straightfromthesourcesmouth.co Website: https://straightfromthesourcesmouthpod.net/Instagram: @fromthesourcesmouth_franktalkTwitter: @tamarapodcastYouTube and IG: Tamara_Schoon_comic

Dr. Florence Comite, MD is a clinician-scientist, endocrinologist, and the leading expert in the fields of healthy longevity and precision medicine. Her international reputation stems from her innovative approach to leveraging proprietary clinical and wearable data in her private clinical and virtual practice to detect, predict, and reverse biological aging, while optimizing health and vitality.   As a graduate of Yale School of Medicine, Dr. Comite served as a faculty member for twenty-five years with a distinguished triple appointment in Endocrinology (Internal Medicine and Pediatrics) and Reproductive Endocrinology (Gynecology and Andrology). During her career, she trained at the National Institutes of Health and founded Women's Health at Yale, establishing the nation's first women-only clinic.   In 2005, Dr. Comite founded the Comite Center for Precision Medicine & Healthy Longevity in New York City, where she developed the groundbreaking Nof1™ clinical process, treating each patient as a single subject clinical trial. The Center's success has led to expansions in Palo Alto and Miami Beach. Her innovative approach has attracted a global clientele, including forward-thinking physicians, industry leaders, and entrepreneurs, each receiving personalized healthcare interventions tailored to their individual needs. Her commitment to advancing medical science is evident through her extensive research and publications in prestigious journals such as the New England Journal of Medicine, JAMA: The Journal of the American Medical Association, and the Journal of the Endocrine Society. Dr. Comite's pioneering research spans across children, women, and men, recognizing the critical role of the entire system in aging and disease.   In 2013, she authored the bestselling book "Keep It Up: The Power of Precision Medicine to Conquer Low T and Revitalize Your Life," focusing on androgen deficiency and vitality in aging men. Her next book, "Invincible: Eliminate the Disorders of Aging for a Healthy, Long Life," will be published by Little Brown, Spark in Spring 2026. Through her startup Groq Health, Dr. Comite is scaling her precise methodology of precision medicine to a digital clinic delivered virtually.   As a sought-after keynote speaker, Dr. Comite continues to captivate audiences worldwide, sharing her expertise and vision for the future of precision medicine and healthy longevity.

In a time marked by anxiety, division and disconnection, the path forward lies not in fixing the past but in expanding our freedom to imagine what's next. In this episode of Learning Through Experience, Dr. Heidi Brooks is joined by Suzi Tucker, a writer, teacher and pioneer of Family Constellations work. Together, they explore how our personal and ancestral stories shape the patterns we repeat—and how stepping into those patterns with curiosity can help us reorient toward hope. With warmth, wisdom and respect for the unknown, Suzi shares how facing uncertainty isn't about certainty at all—it's about accompaniment. It's about standing on the shoulders of those who came before us and choosing, even in fear, to take one generative step toward something more. Through stories of lineage, loss, and liberation, Heidi and Suzi offer listeners an invitation to slow down, pay attention and let learning emerge. “When I plant a seed, that's really all I have to do. I don't know what's going to come. That one generative step is enough.” —Suzi Tucker Learning Through Experience is produced through the Yale School of Management. What resonates with you about this conversation? We'd love to hear from you—reach out to LTEpodcast@yale.edu. And subscribe to the monthly LinkedIn newsletter for additional insights and reflections about episode topics and questions to ponder.  Watch this episode on YouTube. Show Notes & Key Moments 03:00 – A Brother Remembered, a Path Revealed Suzi recalls how the absence of her institutionalized brother shaped her and how an encounter with Bert Hellinger—founder of Family Constellations—marked a turning point. “I decided I had a freedom my mother didn't have, and I used it. I went to meet my brother—not for him to know me, but for me to know him.” 10:16 – The Work of Freedom vs. HealingSuzi explains that her work isn't about fixing the past—it's about freeing people to move forward. “Healing is personal and beautiful, but not necessarily connected to something in the future. Freedom is.” 13:36 – Patterns, Habit and the Energy of StucknessHeidi and Suzi discuss how we get trapped in cycles inherited from our family systems—and how awareness opens space for choice. “Those places where I've done the same thing over and over again—and then I defend it, and get angry at the defense—that's when spirit gets siphoned off.” 18:00 – Group Work, Lineage and AccompanimentSuzi reflects on what emerges in her constellation workshops—and why showing up in community can be a pathway to hope. “When I look at a group of 40, I see 4 million. I'm working not just with people, but with the lineages sitting beside them.” 24:45 – Facing Uncertainty with Ancestral SupportSuzi names the emotional reality of living in uncertain times and how drawing from lineage can be a grounding force. “I call it the lethargy of despair. But then I feel my predecessors stepping in and saying, we've seen this before.” 27:29 – Writing as a Practice of PossibilityFor Suzi, writing becomes a tool to move beyond fear and uncertainty. “I'm writing my path beyond the threshold of fear.” 43:23 – Constellations and a Shift in PerspectiveConstellations offer a way to step outside the chaos and view one's story with new eyes. Heidi and Suzi discuss why representing others in a group can be transformative. “It's not about understanding the system, but knowing there is a system—and it looks different depending on where you stand.” 48:22 – Generative Endings and Ongoing UnfoldingSuzi explains that constellations don't end with solutions, but with new images that change the structure of how people move through life. “I picture my parents behind me, my brother beside me, and I walk forward. And I imagine them saying, We're so glad they didn't stay trapped in our fear.” 53:55 – Something to Sit WithHeidi closes by highlighting the invitation at the heart of this episode: not to solve uncertainty, but to meet it. “Fear is familiar. Possibility is harder to trust—but it's there. And we can take one generative step toward it.” Resources Suzi Tucker's website: Explore Suzi Tucker's website to learn about her upcoming retreats, workshops, and sign up for her newsletter. ‘Til Soon: Paradigm-shifting life prompts through the unique lens of Systemic Constellations, by Suzi Tucker. Acknowledging What Is: Conversations With Bert Hellinger: In this thought-provoking series of dialogues, Bert Hellinger—the originator of the Family Constellation method—offers profound insights into the unseen dynamics that shape family systems. Through real-life examples and practical reflections, he explores how acknowledging hidden entanglements can unlock the path to personal and generational healing. Holding Love: A Teaching Seminar on Love's Hidden Symmetry: Drawn from a live seminar in San Francisco in 1999, this comprehensive three-part resource offers an in-depth look at applying Family Constellations in therapeutic settings. Hellinger guides viewers through the subtle patterns influencing love and relationships, illustrating how the method can reveal underlying forces at play in couples and family work.

Host Dr. Davide Soldato and guest Dr. Harriet Kluger discuss the JCO article "Phase II Trial of Pembrolizumab in Combination With Bevacizumab for Untreated Melanoma Brain Metastases." Transcript The guest on this podcast episode has no disclosures to declare. Dr. Davide Soldato Hello and welcome to JCO After Hours, the podcast where we sit down with authors from some of the latest articles published in the Journal of Clinical Oncology. I am your host, Dr. Davide Soldato, Medical Oncologist at Ospedale San Martino in Genoa, Italy. Today, we are joined by JCO author Dr. Harriet Kluger. Dr. Kluger is a professor of medicine at Yale School of Medicine, Director of the Yale SPORE in Skin Cancer, and an internationally recognized expert in immuno-oncology for melanoma and renal cell carcinoma. She leads early-phase and translational trials that pair novel immunotherapies with predictive biomarkers to personalized care. Today, Dr. Kluger and I will be discussing the article titled "Phase 2 Trial of Pembrolizumab in Combination with Bevacizumab for Untreated Melanoma Brain Metastases." In this study, Dr. Kluger and colleagues evaluated four cycles of pembrolizumab plus the anti-VEGF antibody bevacizumab followed by pembrolizumab maintenance in patients with asymptomatic non-hemorrhagic melanoma brain metastases that had not previously received PD-1 therapy. Thank you for speaking with us, Dr. Kluger. Dr. Harriet Kluger Thank you for inviting me. The pleasure is really all mine. Dr. Davide Soldato So to kick off our podcast, I just wanted to ask if you could outline a little bit the biological and clinical rationale that led you to test this type of combination for patients with untreated brain metastases from metastatic melanoma. Dr. Harriet Kluger Back in approximately 2012, patients who had untreated brain metastases were excluded from all clinical trials. So by untreated, I mean brain metastases that had not received local therapy such as surgery or radiation. The reason for it was primarily because there was this fear that big molecules wouldn't penetrate brain lesions because they can't pass the blood-brain barrier. Turns out that the blood-brain barrier within a tumor is somewhat leaky and drugs sometimes can get in there. When PD-1 inhibitors were first identified as the next blockbuster class of drugs, we decided to conduct a phase 2 clinical trial of pembrolizumab monotherapy in patients with untreated brain metastases. We actually did it also in lung cancer, and we could talk about that later on. Responses were seen. The responses in the brain and the body were similar. They were concordant in melanoma patients. Now, at approximately that time, also another study was done by the Australian group by Dr. Georgina Long, where they did a randomized trial where patients who didn't require immediate steroid therapy received either nivolumab alone or nivolumab with ipilimumab, and the combination arm was substantially superior. Subsequently, also, Bristol Myers Squibb also conducted a large phase 2 multicenter trial of ipilimumab and nivolumab in patients with untreated brain metastases. And there, once again, they saw that the responses in the brain were similar to the responses in the body. Now, somewhere along the line there, we completed our anti-PD-1 monotherapy trial. And when we looked at our data, we still didn't have the data on ipilimumab and nivolumab. And our question was, “Well, how can we do better?” Just as we're always trying to do better. We saw two really big problems. One was that patients had a lot of perilesional edema. And the other one was that we were struggling with radiation necrosis in lesions that were previously Gamma Knifed. The instance of radiation necrosis was in excess of 30%. So the rationale behind this study was that if we added bevacizumab, maybe we could treat those patients who had some edema, not requiring steroids, but potentially get them on study, get that PD-1 inhibitor going, and also prevent subsequent radiation necrosis. And that was the main rationale behind the study. We had also done some preclinical work in mouse models of melanoma brain metastases and in an in vitro blood-brain barrier model where we showed that bevacizumab, or anti-VEGF, really tightens up those leaky basement membranes and therefore would be very likely to decrease the edema. Dr. Davide Soldato Thank you very much for putting in context the combination. So this was a phase 2 trial, and you included patients who had at least one lesion, and you wanted lesions that were behind 5 and 20 millimeters. Patients could be included also if the brain metastasis was higher in dimension than 20 millimeters, but it had to be treated, and it was then excluded from the evaluation of the primary objective of the trial. So regarding, a little bit, these characteristics, do you think that this is very similar to what we see in clinical practice? And what does this mean in terms of applicability of these results in clinical practice? Dr. Harriet Kluger So that's an excellent question. The brain metastasis clinical research field has somewhat been struggling with this issue of inclusion/exclusion criteria. When we started this, we showed pretty clearly that 5 to 10 millimeter lesions, which are below the RECIST criteria for inclusion, are measurable if you use MRIs with slices that are 1 to 2 millimeters. Most institutions in the United States do use these high-resolution MRIs. I don't know how applicable that is on a worldwide scale, but we certainly lowered the threshold for inclusion so that patients who have a smattering of small brain metastases would be eligible. Now, patients with single large brain metastases, the reason that we excluded those from the trial was because we were afraid that if a patient didn't respond to the systemic therapy that we were going to give them, they could really then develop severe neurological symptoms. So, for patient safety, we used 20 millimeters as the upper level for inclusion. Some of the other trials that I mentioned earlier also excluded patients with very large lesions. Now, in practice, one certainly can do Gamma Knife therapy to the large lesions and leave the smaller ones untreated. So I think it actually is very applicable to clinical practice. Dr. Davide Soldato Thank you very much for that insight, because I think that sometimes criteria for clinical trials, they have to be very restrictive. But then we know that in clinical practice, the applicability of these results is probably broader. So, going a little bit further in the results of the study, I just wanted a little bit of comment from you regarding what you saw in terms of intracranial response rate and duration of response among patients who obtained a response from the combination treatment. Dr. Harriet Kluger So we were actually surprised. When we first designed this study, as I said earlier, we weren't trying to beat out ipilimumab and nivolumab. We were really just trying to exclude those patients who wouldn't have otherwise been eligible for ipilimumab and nivolumab because of edema or possibly even previous radiation necrosis. So it was designed to differentiate between a response rate of 34%, and I believe the lower bound was somewhere in the 20s, because that's what we'd seen in the previous pembrolizumab study. What we saw in the first 20 patients that we enrolled was actually a response rate that far exceeded that. And so we enrolled another cohort to verify that result because we were concerned about premature publishing of a result that we might have achieved just by chance. The two cohorts were very similar in terms of the response rates. And certainly this still needs to be verified in a second study with additional institutions. We did include the Moffitt Cancer Center, and the response rate with Moffitt Cancer Center was very similar to the Yale Cancer Center response rate. Now, your other question was about duration of response. So the other thing that we started asking ourselves was whether this high response rate was really because the administration of the anti-VEGF will decrease the gadolinium enhancement and therefore we might actually just be seeing prettier scans but not tumor shrinkage. And the way to differentiate those two is by looking at the duration of the response. Median progression-free survival was 2.2 years. That's pretty long. The upper bound on the 95% confidence interval was not reached. I can't tell you that the duration is as good as the duration would be when you give ipilimumab. Perhaps it is less good. This was a fairly sick population of patients, and it included some who might not have been able to receive ipilimumab and nivolumab. So it provides an alternative. I do believe that we need to do a randomized trial where we compare it to ipilimumab and nivolumab, which is the current standard of care in this patient population. We do need to interpret these results with caution. I also want to point out regarding the progression-free survival that we only gave four doses of anti-VEGF. So one would think that even though anti-VEGF has a long half-life of three or four weeks, two years later, you no longer have anti-VEGF effect, presumably. So it does something when it's administered fairly early on in the course of the treatment. Dr. Davide Soldato So, in terms of clinical applicability, do you see this combination of pembrolizumab and bevacizumab - and of course, as we mentioned, this was a phase 2 trial. The number of patients included was not very high, but still you saw some very promising results when compared with the combination of ipilimumab and nivolumab. So do you see this combination as something that should be given particularly to those patients who might not be able to receive ipilimumab and nivolumab? So, for example, patients who are very symptomatic from the start or require a high dose of steroids, or also to provide a quicker response in terms of patients who have neurological symptoms, or do you think that someday it could be potentially used for all patients? Dr. Harriet Kluger The third part of your question, whether it can be used someday for all patients: I think we need to be very careful when we interpret these results. The study was substantially smaller than the ipilimumab/nivolumab trial that was conducted by Bristol Myers Squibb. Also going to point out that was a different population of patients. Those were all frontline patients. Here we had a mix of patients who'd had previous anti-CTLA-4 and frontline patients. So I don't think that we can replace ipilimumab and nivolumab with these results. But certainly the steroid-sparing aspect of it is something that we really need to take into consideration. A lot of patients have lesions in locations where edema can be dangerous, and some of them have a hard time coming off the steroids. So this is certainly a good approach for those folks. Dr. Davide Soldato And coming back to something that you mentioned in the very introduction, when you said that there were two main problems, which was one, the problem of the edema, and the second one, the problem of the radionecrosis. In your trial, there was a fair percentage of patients who received some type of local treatment before the systemic one. So the combination of pembrolizumab and bevacizumab. And most of the patients received radiosurgery. So I just wanted a brief comment regarding the incidence of radionecrosis in the trial and whether that specific component of the combination with bevacizumab was reduced. And how do you think that this fares in terms of what we see in clinical practice in terms of radionecrosis? Dr. Harriet Kluger I'm not sure that we really reduced the incidence of radiation necrosis. We saw radiation necrosis here. We saw less of it than in the trial of pembrolizumab monotherapy, but these were also different patients, different time. We saw more than we thought that we were going to see. It was 27%, I believe, which is fairly high still. We only gave the four doses of bevacizumab. Maybe to really prevent radiation necrosis, you have to continue to give the bevacizumab. That, too, needs to be tested. The reason that we gave the four doses of bevacizumab was simply because of the cost of the bevacizumab at the time. Dr. Davide Soldato Thank you very much for that comment on radionecrosis. And I really think that potentially this is a strategy, so continuing the bevacizumab, that really makes a lot of sense, especially considering that the tolerability of the regimen was really very, very good, and you didn't see any significant or serious adverse events related to bevacizumab. So just wondering if you could comment a little bit on the toxicities, whether you had anything unexpected. Dr. Harriet Kluger There was one patient who had a microperforation of a diverticulum, which was probably related to the bevacizumab. It was conservatively managed, and the patient did fine and actually remains alive now, many years later. We had one patient who had dehiscence of a previous wound. So there is some. We did not see any substantial hypertension, proteinuria, but we only gave the four doses. So it is possible that if you give it for longer, we would see some side effects. But still, relative to ipilimumab, it's very, very well tolerated. Dr. Davide Soldato Yeah, exactly. I think that the safety profile is really different when we compare the combination of ipilimumab/nivolumab with the pembrolizumab/bevacizumab. And as you said, this was a very small trial and probably we need additional results. But still, these results, in terms of tolerability and safety, I think they are very interesting. So one additional question that I think warrants a little bit of comment on your part is actually related to the presence of patients with BRAF mutation and, in general, to what you think would be the best course of treatment for these patients who present with the upfront brain metastases. So this, it's actually not completely related to the study, but I think that since patients with BRAF mutation were included, I think that this warrants a little bit of discussion on your part. Dr. Harriet Kluger So we really believe that long-term disease control, particularly in brain metastases, doesn't happen when you give BRAF/MEK inhibitors. You sometimes get long-term control if you've got oligometastatic disease in extracranial sites and if they've previously been treated with a lot of immune checkpoint inhibitors, which wasn't the case over here. So a patient who presents early in the course of the disease, regardless of their BRAF status, I do believe that between our studies and all the studies that have been done on immunotherapy earlier in the course of disease, we should withhold BRAF/MEK inhibitors unless they have overwhelming disease and we need immediate disease control, and then we switch them very quickly to immunotherapy. Can I also say something about the toxicity question from the bevacizumab? I have one more comment to make. I think it's important. We were very careful not to include patients who had overt hemorrhage from brain metastases. So melanoma brain metastases relative to other tumor types tend to bleed, and that was an exclusion criteria. We didn't see any bleeding that was attributable to the bevacizumab, but we don't know for sure that, if this is widely used, that that might not be a problem that's observed. So I would advise folks to use extreme caution and perhaps not use it outside of the setting of a clinical trial in patients with overt hemorrhage in the melanoma brain metastases. Dr. Davide Soldato Thank you very much. I think that one aspect that is really interesting in the trial is actually related to the fact that you collected a series of biomarkers, both circulating ones, but also some that were collected actually from the tissue. So just wondering if you could explain a little bit which type of biomarkers you evaluated and whether you saw any significant results that could suggest higher or lower efficacy of the combination. Dr. Harriet Kluger Thank you for that. So yes, the biomarker studies are fairly exploratory, and I want to emphasize that we don't have anything that's remotely useful in clinical practice at this juncture. But we did see an association between vessel density in the tumors and improved response to this regimen. So possibly those lesions that are more vascular are more fed by or driven by VEGF, and that could be the reason that there was improved response. We also saw that when there was less of an increase in circulating angiopoietin-2 levels, patients were more likely to respond. Whether or not that pans out in larger cohorts of patients remains to be determined. Dr. Davide Soldato Still, do you envision validation of these biomarkers in a potentially additional trial that will evaluate, again, the combination? Because I think that the signals were quite interesting, and they really make sense from a biological point of view, considering the mechanism of action of bevacizumab. So I think that, yeah, you're right, they are exploratory. But still, I think that there is very strong biological rationale. So really I wanted to congratulate you on including that specific part and on reporting it. And so the question is, really, do you envision validation of these biomarkers in larger cohorts? Dr. Harriet Kluger I would hope to see that, just as I'd like to see validation of the clinical results as well. The circulating biomarkers are very easy to do. It's a simple ELISA test. And the vessel density on the tumor is essentially CD34 staining and units per area of tumor. Also very simple to do. So I'd love to see that happen. Dr. Davide Soldato Do you think that considering the quality of the MRI that we are using right now, it would be possible to completely bypass even the evaluation on the tissue? Like, are we going in a direction where we can, at a certain point, say the amount of vessels that we see in these metastases is higher versus lower just based on MRI results? Dr. Harriet Kluger You gave me an outstanding idea for a follow-up study. I don't know whether you can measure the intensity of gadolinium as a surrogate, but certainly something worth asking our neuroradiology colleagues. Excellent idea. Thank you. Dr. Davide Soldato You're welcome. So just moving a step further, we spoke a lot about the validation of these results and the combination. And just wanted your idea on what do you think it would be more interesting to do: if designing a clinical trial that really compares pembrolizumab/bevacizumab with ipilimumab and nivolumab or going directly for the triplet. So we know that there has been some type of exploration of triplet combination in metastatic melanoma. So just your clinical impression: What would you do as an investigator? Dr. Harriet Kluger So it's under some discussion, actually. It's very difficult to compare drugs from different companies in an investigator-initiated trial. Perhaps our European colleagues can do that trial for us. In the United States, it's much harder, but it can be done through the cooperative groups, and we are actually having some discussions about that. I don't have the answer for you. It would be lovely to have a trial that compared the three drugs to ipi/nivo and to pembrolizumab/bevacizumab. So a three-arm trial. But remember, these are frontline melanoma patients. There aren't that many of them anymore like there used to be. So accrual will be hard, and we have to be practical. Dr. Davide Soldato Yeah, you're right. And in the discussion of the manuscript, you actually mentioned some other trials that are ongoing, especially one that is investigating the combination of pembro and lenvatinib, another one that is investigating the combination of nivolumab and relatlimab. So just wondering, do you think that the molecule in terms of VEGF inhibition, so bevacizumab versus lenvatinib, can really make a difference or is going to be just a mechanism of action? Of course, we don't have the results from this trial but just wondering if you could give us a general comment or your opinion on the topic. Dr. Harriet Kluger So that's a really great question. The trial of pembrolizumab and lenvatinib was our answer to the fact that bevacizumab is not manufactured by the same company as pembrolizumab, and we're trying to give a practical answer to our next study that might enable us to take this approach further. But it does turn out from our preclinical studies that bevacizumab and VEGF receptor inhibition aren't actually the same thing in terms of the effects on the blood-brain barrier or the perilesional tumor microenvironment in the brain. And these studies were done in mice and in in vitro models. Very different effects. The lenvatinib has stronger effect on the tumors themselves, the tumor cells themselves, than the bevacizumab, which has no effect whatsoever. But the lenvatinib doesn't appear to tighten up that blood-brain barrier. Dr. Davide Soldato Thank you. I think that's very interesting, and I think it's going to be interesting to see also results of these trials to actually improve and give more options to our patients in terms of different mechanism of action, different side effects. Because in the end, one thing that we discussed is that some combination may be useful in some specific clinical situation while others cannot be applicable, like, for example, an all immunotherapy-based combination. Just one final comment, because I think that we focused a lot on the intracranial response and progression-free survival. You briefly mentioned this but just wanted to reinforce the concept. Did you see any differences in terms of intracranial versus extracranial response for those patients who also had extracranial disease with the combination of pembro and bevacizumab? Dr. Harriet Kluger So the responses were almost always concordant. There were a couple of cases that might have had a body response and not an intracranial response and vice-versa, but the vast majority had concordant response or progression. We do believe that it's a biological phenomenon. The type of tumor that tends to go to the brain is going to be the type of tumor that will respond to whatever the regimen is that we're giving. In the previous trial also, we saw concordance of responses in the body and the brain. Dr. Davide Soldato Thank you very much. Just to highlight that really the combination is worth pursuing considering that there was not so much discordant responses, and the results, even in a phase 2 trial, were very, very promising. So thank you again, Dr. Kluger, for joining us today and giving us a little bit of insight into this very interesting trial. Dr. Harriet Kluger Thank you for having me. Dr. Davide Soldato So we appreciate you sharing more on your JCO article titled "Phase 2 Trial of Pembrolizumab in Combination with Bevacizumab for Untreated Melanoma Brain Metastases," which gave us the opportunity to discuss current treatment landscape in metastatic melanoma and future direction in research for melanoma brain metastasis. If you enjoy our show, please leave us a rating and review and be sure to come back for another episode. You can find all ASCO shows at asco.org/podcasts.   The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.

Navigating Medicine and Faith: A Conversation with Dr. Sharon Stoll In this episode, Dr. Sharon Stoll discusses her background growing up in a modern Orthodox Jewish community in Philadelphia, her journey to becoming a neuroimmunologist, and her professional experiences working at Yale and now in Philadelphia. The conversation touches on her approach to patient education, especially around COVID-19 and various medications, including GLP-1 agonists like Ozempic and SSRIs for mental health. Dr. Stoll also speaks about her role in JOWMA (Jewish Orthodox Women's Medical Association) and the importance of educating her community on medical issues.    The discussion covers her views on IVF, the ethical considerations of genetic selection, and the interplay of anxiety and genetic predispositions within the Ashkenazi Jewish community. Dr. Stoll shares personal anecdotes and insights into balancing professional and personal life, making this an in-depth and enlightening conversation.   00:00 Introduction and Background 01:19 Professional Journey and Achievements  02:08 Balancing Media and Medicine 03:48 Involvement with Jowma 05:40 Views on Vaccination 14:26 Discussion on SSRIs and Ozempic 28:16 Challenges in the Frum Community  34:38 Debunking Misconceptions About Diabetes 35:07 Educational Gaps and Community Efforts 36:43 Health Education in Schools 39:06 Challenges of Motherhood and Societal Expectations 43:43 Genetic Risks and Mental Health in Ashkenazi Jews 54:38 IVF, Genetic Selection, and Ethical Dilemmas  01:02:34 Concluding Thoughts and Personal Reflections   About Our Guest: Dr. Sharon Stoll is a board-certified neurologist, neuro-immunologist. She currently serves as Director of Neurology at Stoll Medical Group in Philadelphia. For the past 8 years she worked as assistant professor, in the department of neurology at Yale School of Medicine. She completed her neurology residency training at Thomas Jefferson University Hospital in Philadelphia and her Neuroimmunology fellowship at Yale New Haven Hospital. Dr. Stoll played an active role in academic development and continuing medical education. She currently serves on several steering committees and advisory boards. She has been published in numerous peer-reviewed journals and served as Principal Investigator on several clinical trials. Dr. Stoll has received numerous awards, including Top Neurologist, 40 under 40, the Rodney Bell teaching award, and is a national multiple sclerosis society grant recipient. Dr. Stoll is also a medical editor for Medscape and Healthline and previously worked as a medical editor for ABC News. She is also a medical commentator for several national and local news outlets, including ABC, NBC, and CBS News, and has been on a variety of shows, including “The Doctors”. She is an internationally renowned speaker and patient advocate.   https://www.drsharonstoll.com https://www.instagram.com/drsharonstoll/?hl=en https://www.jowma.org  

How can storytelling deepen our understanding of emotional connection in turbulent times? Join Heidi Brooks for a powerful and special episode of Learning Through Experience featuring returning guest Marc Brackett, along with filmmakers Horacio Marquínez and Kirill Myltsev. Together, they explore the extraordinary journey behind their documentary, America Unfiltered: Portraits and Voices of a Nation, a film born out of curiosity, human connection and the transformative power of experience. Listen (and watch!) as they share deeply moving stories, from unexpected moments of vulnerability to profound encounters that challenge assumptions about identity, belonging, and resilience. This conversation beautifully demonstrates how art and genuine interpersonal connection serve as tools for learning, understanding and bridging divides. Don't miss this inspiring dialogue that invites us all to witness the intimate storytelling behind America Unfiltered and to see each other—and ourselves—with greater empathy, curiosity and compassion.  Learning Through Experience is produced through the Yale School of Management. What resonates with you about this conversation? We'd love to hear from you—reach out to LTEpodcast@yale.edu. And subscribe to the monthly LinkedIn newsletter for additional insights and reflections about episode topics and questions to ponder.  Watch this episode on YouTube. Show Notes & Key Moments 00:00 – Opening ReflectionDr. Heidi Brooks sets the stage by sharing how art and interpersonal dynamics help us learn deeply through experience. “Art opens us up and helps us see the world through a more expansive lens… interpersonal dynamics between us are eternally fascinating.”  03:40 – Driven by Curiosity and Need for ConnectionHoracio Marquinez shares the deep personal calling that led him to start this ambitious project during the isolation of the pandemic. “This film was driven by our heart and by our guts…I needed to see what other people were experiencing.” 05:16 – An Immigrant's Lens: America Through Fresh EyesKirill Myltsev shares how being new to America heightened his curiosity and compelled him to explore its complexities firsthand.“You think you know the U.S., but then realize you're in a bubble. The pandemic made me curious.” 14:04 – Moments of Unexpected VulnerabilityThe filmmakers recall a transformative encounter with a gun shop owner in Arizona, whose emotional openness set the film's tone. “Within 15 minutes, Chris broke into tears. It solidified that this project was bigger than us.” 16:36 – America's Emotional UnderbellyHoracio describes the raw emotional openness of the people they met. “We weren't fishing for tears—they just came. Tears, laughter, stories about love.” 23:25 – Shattering Stereotypes, One Story at a TimeMarc Brackett emphasizes how the film breaks down stereotypes and assumptions, inviting viewers to pause and reconsider what they think they know. “All people aren't the same. The film makes you question your assumptions.” 30:00 – A Powerful Partnership: Creative Tension as a CatalystHeidi highlights the unique partnership and chemistry between Horacio and Kirill that became integral to the film's story. “Transparency actually brings us closer. Their relationship became its own story.” 43:22 – Portraits of AuthenticityHoracio describes the intentionality behind his powerful portraits. “I wanted people to present themselves as they wanted me to see them.” Resources Watch America Unfiltered on Kanopy, Amazon Prime Video and Tubi beginning April 25 Experience more than 100 powerful portraits captured by Horacio Marquínez during their journey in the book America Unfiltered: Portraits and Voices of a Nation Deepen your emotional intelligence with Marc Brackett and (re)watch/listen to his first Learning Through Experience episode: Emotional Wisdom and the Permission to Feel 

In today's episode, we had the pleasure of speaking with Daniel P. Petrylak, MD, about Lutetium Lu 177 vipivotide tetraxetan (Pluvicto) in metastatic castration-resistant prostate cancer (mCRPC). Dr Petrylak is a professor of medicine (medical oncology) and urology, as well as the chief of Genitourinary Oncology, at Yale School of Medicine and Smilow Cancer Hospital in New Haven, Connecticut. In our exclusive interview, Dr Petrylak discussed the current role for Pluvicto in patients with mCRPC, the safety profile of this radiotherapeutic, the importance of multidisciplinary collaboration when delivering this therapy, and future directions for investigating radioligand therapies in combination with other classes of agents.

“There was a sense of discovery about what this series was going to be about. It was going to be about young people -- with all of their shenanigans, and the maneuvering, and all the silliness that takes place with that. But it was also going to be about growing up. These five people, and the fabric that holds them together.”  -- Asaad Kelada - producer/director, The Facts of LifeSusan and Sharon welcome legendary Director Asaad Kelada. In a career spanning four decades, Asaad Kelada has directed over 340 episodes of television, including Rhoda, Phyllis, The Tony Randall Show, Benson, WKRP in Cincinnati, One Day at a Time, Night Court, Valerie, Who's the Boss and The Office -- as well as four seasons of The Facts of Life. In Part 1 of this wide-ranging interview, we touch on Asaad's relationship to the young actors on Facts of Life; learning to trust them -- and himself; and his beginnings as the lead singer in Egypt's first ever Rock ‘n' Roll Boy Band!  THE CONVERSATIONWHAT I REALLY WANT TO DO IS DIRECT! - How getting accepted to the Yale School of Drama taught Asaad which side of the stage he really wanted to be on.THE 5-YEAR DIRECTING SCHOOL: Observing all the MTM shows from the bleachers, for five years, got Asaad ready for his first TV job: Directing Valerie Harper in Rhoda!DAY ONE: On his first day directing The Facts of Life, the only person he recognized that he had worked with before was… Tootie (Kim Fields)!DOUBLE STANDARD: In this early episode of The Facts of Life, Asaad realized the potential of the show: “It was just like being in the theater, like working on a play --  with substance, with humor, with intelligence -- and yet they were young girls. This was television in a new form.RUNAWAY TRAIN: Asaad describes the increasing tension and hi-stakes artistry of a show as it speeds thru its season -- and how he learned to not fall off!ON CHARLOTTE RAE: “She and I were the grownups in the room. She was the centerpiece in a show about four girls.”STORY CONFERENCE -- WITH THE CAST: “After the table read, we'd just talk -- talk about what the episode is dealing with, what it's about, how it all ties together.”FACTS OF LIFE GOES TO PARIS: “It was a trial by fire. Every single shot, every single frame was filmed on location. We were at Notre Dame, the Champs Elysee… How can this be called a job?”So join Susan and Sharon -- and Asaad -- as they talk George Clooney, The Bob Newhart Show, Grant Tinker, Geri Jewel, speaking French, Bill Haley & the Comets, Nancy McKeon -- and being ready when your opportunity finally comes!GET READY FOR PART 2 -- NEXT EPISODE! Don't miss more Facts of Life stories, plus Family Ties and Who's The Boss!!AUDIO-OGRAPHYFind out more about Asaad Kelada at IMDB.STILL IN FLUX: Watch Season 2 and 3 of The Facts of Life for free on Tubi.Season 1 and 3 are available for sale on Amazon Prime.Buy the complete season on DVD at Ebay. Check YouTube for other episodes.VITAL READINGGet Handbook for A Post-Roe America by Robin Marty at Bookshop.org.Check out Men In Dark Times by Hannah Ahrendt at Bookshop.org.Read Democracy Awakening by Heather Cox Richardson at Bookshop.org.CONNECTVisit 80sTVLadies.com for transcripts.Sign up for the 80s TV Ladies mailing list.Support us and get ad-free episodes on PATREON. This year is the 45th anniversary of President Carter's Crisis of Confidence speech. Get Susan's new play about it: Confidence (and the Speech) at Broadway Licensing.

The cordyceps brain infection that turns humans into terrifying monsters in The Last of Us is something that already exists in our world. So is it time to start worrying about Clickers and other fungus zombies?We are going to cut right to the chase on this one: Cordyceps, the brain infecting fungus that causes people to mutate into increasingly grotesque zombies in The Last of Us video games and the HBO TV adaptation, is very real. Of this, there is no doubt, as you'll see in our episode and read below. But like any good sci-fi, horror, or fantasy storytelling, the secret isn't so much in how realistic something is, but in how it obeys its own rules in-story.After all, who the heck needs a story about a devastating pandemic that was exacerbated by global warming these days, right? It's not like sci-fi and horror have ever been used to illustrate real world issues before. Why not just let escapism be escapism and leave all this uncomfortable real world stuff out of it?In case you couldn't sense the sarcasm (Does it Fly? is a Roddenberry podcast after all, and it's not like Star Trek has ever been shy about taking our present moment to task via the denizens of the 23rd, 24th, and 25th centuries), the inherent realism of The Last of Us is an integral part of what makes it work. But it's far from the only reason we're so enamored with this disturbing sci-fi and horror hybrid. And that's where Hakeem and Tamara come inWatch the latest episode of Does it Fly? right here (and try not to eat any infected grain)...https://www.youtube.com/watch?v=h8141JQ_kesSUGGESTED VIEWING One of the best things about The Last of Us is that the show is 100% accessible for folks who have never played the video games. It's also, perhaps not coincidentally, one of the only truly great video game to screen adaptations we've ever seen. We based our conversation for this episode on the first season of the show, but if you've even watched the first two episodes, you can probably keep up. Oh, just watch the entire first season!For some additional fungus-induced “fun” we also recommend the brilliant 2016 sci-fi horror movie The Girl With All the Gifts, which mines some similarly terrifying themes as The Last of Us.And don't forget, The Last of Us season 2 just kicked off on HBO and MAX so what are you waiting for? Go get caught up! Who knows? This could just be something in our future…FURTHER READING Do you want to delve a little deeper into the facts, concepts, and stories Hakeem and Tamara referenced in today's episode? Of course you do! The Zombie Ants Are Already HereThe intricately orchestrated way this fungus takes over insect brains and makes them do their bidding sure does give us something to think about. Read more at National Geographic! Fortunately, it doesn't seem like we have to worry too much about this becoming a human issue…just yet.Fungal PathogensIt even sounds gross when we put it that way. The Last of Us is so dead-on with its depiction of global-warming induced fungal infections that no less than the Yale School of Medicine wrote about it.Respiratory vs. Fungal InfectionsWe usually don't associate the usual respiratory viruses with fungal infections. But this article asks…why not both?A Guide to Knowing and Loving Your Infected Fungus ZombiesProper care and feeding for their lifecycle is important. Not really…run! Read more here.WANT MORE FROM DOES IT FLY?Black Mirror is back with a brand new season on Netflix. Check out our episode on one of its most iconic episodes, “San Junipero” right here!Whether fungus zombies or otherwise, we do occasionally take a look at the scarier side of genre entertainment from time to time. Like our episode on werewolves, for example.FOLLOW US!Stay in the loop! Follow DoesItFly? on YouTube and TikTok and let us know what you think! Subscribe to Does It Fly? Pod: https://www.youtube.com/@doesitflypod?sub_confirmation=1And don't forget to follow Roddenberry Entertainment:Instagram: @RoddenberryOfficial Facebook: RoddenberryBluesky: @roddenberrypod.bsky.socialFor Advertising Inquiries: doesitfly@roddenberry.comCheck out the official Does it Fly? playlist, too!

What does it take to cultivate joy—not as a fleeting feeling, but as a steady presence—even in times of deep uncertainty? In this luminous conversation, Dr. Heidi Brooks is joined by psychologist and author Emma Seppälä and artist Clara Nartey to explore the resilient, regenerative power of joy. With insights drawn from neuroscience, personal experience and artistic practice, Emma and Clara reflect on how inner sovereignty—the ability to return to center amid chaos—can help us meet the world with greater creativity, calm, and connection. From Clara's practice of beginning each day in prayerful gratitude to Emma's decades of meditation and breathwork, Heidi and her guests share how joy can be cultivated as a discipline of attention and care, and reflect on joy as an “inside job”—one that begins with how we treat ourselves and ripples outward in our relationships, our work and our communities. Together, they invite us to consider: What might it look like to build a “circle of delight” around ourselves and others—a nest of safety, authenticity and beauty?  This episode is for anyone seeking a more rooted, soulfully sustainable way to face uncertainty—and to offer something healing to the world in return. Learning Through Experience is produced through the Yale School of Management. What resonates with you about this conversation? We'd love to hear from you—reach out to LTEpodcast@yale.edu. And subscribe to the monthly LinkedIn newsletter for additional insights and reflections about episode topics and questions to ponder.  Watch this video on YouTube.   Resources Read "Sovereign: Reclaim Your Freedom, Energy, and Power in a Time of Distraction, Uncertainty, and Chaos" by Emma Seppälä See Clara Nartey's artwork, including her “Joy of Living” installation at Yale School of Management's Evans Hall  Follow Emma's Psychology Today blog series, “Feeling It”  Listen to Clara's first Learning Through Experience conversation with Dr. Heidi Brooks: “The Power of Art to Cultivate Joy”   Show Notes & Key Moments 00:00 – Welcome Back to JoyHeidi sets the stage for a conversation about joy as a practice of resilience during uncertain times–and a shared realization that joy often appears where you least expect it. 02:14 – Boarding School, Pandemic, and the Birth of JoyClara shares how hardship shaped her commitment to joy: “You either succumb to the situation—or find a way out using joy.” 03:42 – Inner Wealth, Outer PovertyEmma reflects on cultures where joy thrives in the absence of material wealth: “You can't put the human spirit down.” 08:45 – Training the Mind for TurbulenceEmma offers practices like breathwork and meditation as tools to cultivate resilience and unlock creativity: “The quality of your life depends on the state of your mind.” 14:35 – Art as Emotional TranslationClara describes how her joy—or pain—flows directly into her textile work, regardless of what's visible on the surface. Both Clara and Emma speak to the mystery of creativity: “It's like the work is asking to be made—and I'm just the channel.” 23:19 – The Trouble With Toxic PositivityThey explore the power of authenticity over forced optimism: “Sometimes the most uplifting thing is just being present through the hard stuff.” 33:37 – What Is Sovereignty?Emma defines it as reclaiming our inner space from inherited self-criticism: “You can't unsee what you've seen.” 37:23 – Joy Begins With You        Clara reminds us: “You can't give joy to others from a place of emptiness.” And something to sit with: Something to sit with: “Gratitude will float you through the rushing waters.”

In this episode, Dr. Ryan Alexander joins the show to discuss findings from his new study Withdrawal Signs and Symptoms Among Patients Positive for Fentanyl With and Without Xylazine.    Dr. Ryan Alexander is an addiction medicine specialist and is currently the medical director for substance use services at McNabb Center in Knoxville, TN and is an assistant professor at the University of Tennessee Graduate School of Medicine. He completed medical school at the DeBusk College of Osteopathic Medicine in East Tennessee, his residency in preventive medicine and public health at Griffin Hospital/Yale School of Medicine, and a fellowship in addiction medicine at Yale University School of Medicine. In addition, he completed a Masters of Public Health at Yale School of Public Health. In addition to treating patients, Dr. Alexander conducts clinical research and has published multiple articles related to addiction medicine. He also regularly teaches medical students, residents, and other medical professionals about treating substance use disorders, reducing community stigma toward individuals with substance use disorders, and expanding access to medication treatments. - Article link: Withdrawal Signs and Symptoms Among Patients Positive for Fentanyl With and Without Xylazine

They say the wind is driving the whales crazy. BONUS EPISODES available on Patreon (https://www.patreon.com/deniersplaybook) SOCIALS & MORE (https://linktr.ee/deniersplaybook) WANT TO ADVERTISE WITH US? Please contact climatetownsponsorships@gmail.comDISCLAIMER: Some media clips have been edited for length and clarity. CREDITS Created by: Rollie Williams, Nicole Conlan & Ben BoultHosts: Rollie Williams & Nicole ConlanExecutive Producer: Ben Boult Editors: Ben Boult & Laura ConteProducers: Irene Plagianos, Daniella PhilipsonAssociate Producer: Miranda Manganaro Archival Producer: Margaux SaxAdditional Research and Fact Checking: Carly Rizzuto & Canute HaroldsonMusic: Tony Domenick Art: Jordan Doll Special Thanks: The Civil Liberties Defense CenterSOURCESAnderson, D. (2023, October 23). Fossil fuel money lurks behind anti-offshore wind power political ads in New Jersey. Energy and Policy Institute. Anderson, D. (2024). Fueling the Opposition. Energy and Policy Institute. Axelrod, J. (2024, June 26). Whales Are Dying but Not from Offshore Wind. Scientific American.BGNews. (2023, May 3). JFarage: The Trump Interview | Wednesday 3rd May. YouTube. Berger, I. (2025, February 4). Years of falsehoods from Fox News helped solidify offshore wind as a prime target for Trump. Media Matters for America. Berke, B. (2025, January 22). Prysmian abandons plans for offshore wind cable factory in Somerset. The Public's Radio; Rhode Island PBS. Chapman, M. (2025, January 8). Are Offshore Wind Farms Actually Harming Whales? IFLScience. Choma, R. (2020, August 4). The biggest Trump financial mystery? Where he came up with the cash for his Scottish resorts. Mother Jones. Daly, M. (2018, November 30). Trump admin approves seismic surveys for Atlantic drilling. AP News. Farrell, R. (2024, December 11). Too hot for humpbacks: The race to protect Pacific whales. BBC. Fox News. (2023, February 1). Tucker examines what's behind the deaths of humpback whales. YouTube. Fox Business. (2023, February 23). Are wind turbines killing whales? YouTubeFrequent Questions—Offshore Wind and Whales. (2024, March 14). NOAA Fisheries. Griffiths, B. (2016, November 22). Trump tweeted about Scottish wind farm 60 times. POLITICO. Hardach, S. (2025, January 30). Which is worse for wildlife, wind farms or oil drilling? BBC. Lewis, A. S. (2023, March 8). The East Coast Whale Die-Offs: Unraveling the Causes. Yale E360; Yale School of the Environment. Lutz, M., & Rowland-Shea, J. (2023, December 11). The Oil and Gas Industry Is Behind Offshore Wind Misinformation. Center for American Progress. Machette, T. L., & Lemonick, M. D. (2020, October 4). When Whales Stop Calling. Scientific American. Mathis, W., & Ferman, M. (2025, January 30). Shell Takes $1 Billion Hit on Wind Farm Trump Wants ‘Dead.' Bloomberg. PowerfulJRE. (2024, October 25). Joe Rogan Experience #2219 - Donald Trump. YouTube. Roadmap and Implementation. (2017). Ocean Noise Strategy; NOAA. Seismic Airgun Blasting in the Atlantic Ocean. (2021, May 21). Earthjustice. Slevin, I., Kattrup, W., & Roberts, T. (2023). Against the Wind: A Map of the Anti-Offshore Wind Network in the Eastern United States. Brown University Climate and Development Lab. Silva, M., & Horton, J. (2023, September 26). Fact-checking Donald Trump's claim that wind turbines kill whales. BBC. Spring, J. (2025, February 16). Trump's war on wind seems to be winning, experts say. The Washington Post. Stevens, A. P. (2024, May 9). Are offshore wind farms harming right whales? Woods Hole Oceanographic Institution. The White House. (2025, January 2). Temporary Withdrawal of All Areas on the Outer Continental Shelf from Offshore Wind Leasing and Review of the Federal Government's Leasing and Permitting Practices for Wind Projects. Understanding Sound in the Ocean | NOAA Fisheries. (n.d.). NOAA Fisheries. White, S. (2024, March 1). Fossil Fuel Interests and Dark Money Donors Are Behind Opposition to Offshore Wind. Conservation Law Foundation. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Hear a discussion on the stability of the US financial system, featuring Steven Kelly, Associate Director of Research at Yale School of Management, Leslie Falconio, Head of Taxable Fixed Income, CIO Americas

Today, on Notable Leaders' Radio, I speak with Chad Levefre, Co-Founder of The Most Important Conversations. He highlights innovative solutions like leveraging video game development for positive behavior change and his Whole Life Architecture program.   In today's episode, we discuss: Discover What Expansive Thinking Can Do For You - Chad shares the childhood influences that sparked his curiosity about the universe and life's broader questions. Listening to him, I saw life through his eyes, opening me up to think differently.  I'm curious if you will have the same experience. Our Brain Rewards Us For Almost-Winning Behavior- Chad explains that our brains are wired to give us a neurochemical reward—specifically, a dopamine rush—not just when we win, but even more so when we almost win. He calls this the "near win" effect. Using the example of a slot machine, he describes how getting two out of three matching symbols (almost winning) triggers more dopamine than a real win. shedding light on why we often start but don't finish tasks. This realization can empower them to break those patterns and accomplish their goals. Navigate Emotional Challenges with Emotional Sobriety - The concept of emotional sobriety emphasizes the importance of processing and learning from emotions. This can help you better manage your emotions and align more deeply with your true self. Reframe Addiction as Reinforced Behavior - When Chad shared this, it took me a moment to understand what he was saying—interesting and thought-provoking. Have a listen to see if it resonates with you.   RESOURCES: Complementary Resources:   https://www.inc.com/tracy-leigh-hazzard/building-fans-by-connecting-brands-to-brains.html    Guest Bio Chad Lefevre is an international Design Thinker, business philosopher and strategist, author, and speaker with twenty years of senior business experience, successfully designing business strategy, and leading cultural transformation and leadership development initiatives.  Chad's work centers around being-centered human potential, and is focused on designing and delivering on what is possible when human beings are in alignment, empowered and supported to overcome limiting perceptions and beliefs, to increase performance and deliver desired outcomes for themselves and the companies they work for.    Chad is co-founder of The Most Important Conversations.com (TMIC) a ground-breaking weekly online transformation workshop community some have referred to as “AA for healthy normals”. He was also founder of NeuroBe Inc., a research and consulting firm focused on delivering profound performance inside of corporations by working with leaders in the areas of Being, perception, and cognitive mastery. Website/Social Links https://tmicglobal.com  https://www.linkedin.com/in/chadlefevre Belinda's Bio: Belinda Pruyne is a renowned Leadership Advisor, Executive Coach, Consultant, and Keynote Speaker recognized for her ability to transform executives, professionals, and small business owners into highly respected, influential leaders. As the Founder of BelindaPruyne.com, she partners with top-tier organizations, including IBM, Booz Allen Hamilton, BBDO, Hilton, Leidos, Yale School of Medicine, Landis, Discovery Channel, and the Portland Trail Blazers. Recently, she led the redesign of two global internal advertising agencies for Cella, a leader in creative staffing and consulting. She is also a founding C-suite and executive management coach for Chief, the fastest-growing executive women's network. A thought leader in leadership development, Belinda is the creator and host of the Notable Leaders Radio podcast, where she has conducted 95+ interviews with top executives and business leaders, revealing the untold stories behind their success. Previously, as Executive Vice President, Global Director of Creative Management at Grey Advertising, she oversaw a global team of 500 professionals, gaining deep expertise in client services and executive leadership. With 25+ years of experience, Belinda is a trusted advisor to startups, turnarounds, acquisitions, and Fortune 500 companies, delivering strategic, high-impact solutions in today's fast-evolving business landscape.     Website: Belindapruyne.com Email Address: hello@belindapruyne.com LinkedIn: https://www.linkedin.com/in/belindapruyne  Facebook: https://www.facebook.com/NotableLeadersNetwork.BelindaPruyne/  Twitter: https://twitter.com/belindapruyne?lang=en  Instagram: https://www.instagram.com/belindapruyne/ 

Dr. T and Truth Fairy welcome Greg Wrenn, a former Alabama state representative and long-time health policy advocate, who shares insights into how he became interested in the therapeutic use of psychedelics through personal research and professional exposure. Greg recently wrote a book called “Mothership” about coral reef research, ecological crisis, and his personal PTSD healing journey with ayahuasca. He discusses portions of the book and his experiences with Truth and Dr. T.  Greg explores the growing interest in psychedelic-assisted therapy, particularly its potential to help individuals who struggle with mental health issues such as depression, anxiety, and PTSD. He addresses the shift from viewing psychedelics as taboo to recognizing their potential under controlled, clinical settings. His personal stories, alongside those shared by Truth, highlight the positive impact psychedelic therapy can have and how his passion for the issue has been fueled. Truth Fairy, Dr. T, and Greg share concerns about the challenges of implementing beneficial psychedelic healing sessions, and they celebrate Greg's integration of tribal and liberating dance into the ayahuasca ceremony. They talk about the importance of regulation, ethical safeguards, and integration of Indigenous practices, and caution against the risks of commercialization. The episode is both vulnerable and informative, painting a hopeful picture of potential healing even in the face of difficult times.“You know, I'm no psychedelic evangelist. I don't think everyone should drink ayahuasca or work with psychedelics. I know I should, I know I need to. And so this is really important for my mission, which is to, I guess, spread a message of love and spread a message of the possibility of planetary healing, because planetary healing happens, at least with humanity, one brain at a time.” - Greg Wrenn__About Greg Wrenn:A former Stegner Fellow and Jones Lecturer at Stanford University, GREG WRENN is the author of the ayahuasca eco-memoir Mothership: A Memoir of Wonder and Crisis, an evidence-based account of his turning to coral reefs and psychedelic plants to heal from childhood trauma, and Centaur (U of Wisconsin Press 2013), which National Book Award-winning poet Terrance Hayes awarded the Brittingham Prize. ​Greg's work has appeared or is forthcoming in HuffPost, The New Republic, Al Jazeera, The Rumpus, LitHub, Writer's Digest, Kenyon Review, New England Review, The Iowa Review, and elsewhere. He has received awards and fellowships from the James Merrill House, the Bread Loaf Writers' Conference, the Vermont Studio Center, the Poetry Society of America, the Hermitage Artist Retreat, the Virginia Center for the Creative Arts, and the Spiro Arts Center. On his Mothership book tour, he spoke to audiences around the world, including at Yale School of Medicine, the University of Utah School of Medicine, Vancouver Island University, and the University of Virginia School of Nursing. Greg has also been on numerous podcasts, including Levi Chambers's PRIDE, and was recently interviewed by Emmy Award-winning journalist Elizabeth Vargas on NewsNation​ and by Jane Garvey on Times Radio (UK). ​As an associate English professor at James Madison University, he teaches creative nonfiction, poetry, and environmental literature and directs the JMU Creative Writing Minor. He also teaches in the Memoir Certificate Program at Stanford Continuing Studies. He was educated at Harvard University and Washington University in St. Louis.Greg is currently at work on a follow-up book to Mothership and sending out Homesick, his second poetry collection. A student of ayahuasca since 2019, he is a trained yoga teacher and a PADI Advanced Open Water diver, having explored coral reefs around the world for over 25 years. He and his husband divide their time between the mountains of Virginia and Atlantic Beach, Florida.Website: GregWrenn.comBook: “Mothership: A Memoir of Wonder and Crisis” by Greg Wrenn__Contact Punk Therapy:Patreon: Patreon.com/PunkTherapyWebsite: PunkTherapy.comEmail: info@punktherapy.com Contact Truth Fairy: Email: Truth@PunkTherapy.com

In this episode of Shared Humanity: The humans behind the headlines, host Nelba Márquez-Greene, Yale School of Public Health Community Scholar, is joined by the two former deputy directors of the White House Office of Gun Violence Prevention, Gregory Jackson and Rob Wilcox. They discuss the successes of the Office — we saw the biggest reduction in gun violence in U.S. history — and how those accomplishments can continue to be replicated, even after the Office's closure. "We have the solutions that work," said Wilcox. "We just need to put them in place." Learn more about Shared Humanity: https://sph.yale.edu/sharedhumanity Follow the Yale School of Public Health:  Bluesky: https://bsky.app/profile/yalesph.bsky.social  Instagram: https://www.instagram.com/yalesph/ Facebook: https://www.facebook.com/YaleSPH/ LinkedIn: https://www.linkedin.com/school/yalesph/ Threads: https://www.threads.net/@yalesph TikTok: https://www.tiktok.com/@yalesph  

Ali Velshi is joined by President and Founder of the Eurasia Group & GZERO Media Ian Bremmer, former Chairman and President of the Export-Import Bank of the United States Fred Hochberg, former Associate at Skadden, Arps, Slate, Meagher, & Flom Rachel Cohen, Managing Partner of Mark S. Zaid, P.C. Mark Zaid, former Secretary of Treasury Lawrence Summers, North Carolina Supreme Court Justice Allison Riggs, Senior Associate Dean for Leadership at the Yale School of Management Jeffrey Sonnenfeld & fmr. asst. Chief Negotiator for the Office of the U.S. Trade Representative J. Nicole Bivens Collinson

Today, on Notable Leaders' Radio, I speak with Judy ‘J.' Winslow, founder of UnforgettableBrands. She highlights the importance of embracing uniqueness and standing out in personal and professional spheres.   In today's episode, we discuss: Judy Winslow's Transformational Journey: Discover how Judy's relationship with her mom, dubbed the "School of Don'ts," taught her resilience and personal growth. Learn from her story about the potential for growth from challenging relationships. Leadership and Conscious Choices: The importance of owning your journey and making deliberate choices. Understand how responsibility can empower you to shape your success. Crafting a Personal Path to Success: Define success on personal terms  Creativity in Any Profession: The presence of creativity in all fields and how constraints can enhance it. Encouragement to find and express your truth instead of following societal norms. Motivate yourself to pursue and define your unique success story. Your creativity at work, no matter your field. Personal Responsibility for Change: Learn how Judy changed her life by taking personal responsibility and shifting her mindset. Inspiring you to make conscious choices for personal transformation. Embrace your inner weirdo! Judy's journey shows us that it's not about fitting in, it's about standing out. True success comes from being unapologetically you.   Guest Bio: Judy (who goes by J.), Winslow is a trusted advisor to high-level leaders ready to multiply their business, brand, and legacy by 2-5X.  A dynamic speaker, elite business strategist, and leadership mentor, she equips CEOs and C-suite executives with the tools to drive innovation, amplify influence, and unlock exponential growth. Her career spans decades of high-impact achievements—co-founding a top NYC marketing firm serving Fortune 100s and startups, winning numerous design awards, and founding TEDxSarasota. As a Certified Canfield Success Principles Trainer and a two-time International Best-Selling Author, she has been featured in Business Insider, Yahoo! Finance, ABC, SmileJamaica, and more. With a global roster of visionary leaders, J. Winslow is a catalyst for transformation, inspiring those who refuse to settle for anything less than extraordinary. Whether through speaking, training, or advisory services, she ignites lasting change—fueling business success and leadership excellence at the highest levels. Website/Social Links: jw@Unforgetablebrands.com  UnforgettableBrands.com   https://www.facebook.com/judywins https://www.instagram.com/jwinsceopro/ https://www.linkedin.com/in/judywins/   Belinda's Bio: Belinda Pruyne is a renowned Leadership Advisor, Executive Coach, Consultant, and Keynote Speaker recognized for her ability to transform executives, professionals, and small business owners into highly respected, influential leaders. As the Founder of BelindaPruyne.com, she partners with top-tier organizations, including IBM, Booz Allen Hamilton, BBDO, Hilton, Leidos, Yale School of Medicine, Landis, Discovery Channel, and the Portland Trail Blazers. Recently, she led the redesign of two global internal advertising agencies for Cella, a leader in creative staffing and consulting. She is also a founding C-suite and executive management coach for Chief, the fastest-growing executive women's network. A thought leader in leadership development, Belinda is the creator and host of the Notable Leaders Radio podcast, where she has conducted 95+ interviews with top executives and business leaders, revealing the untold stories behind their success. Previously, as Executive Vice President, Global Director of Creative Management at Grey Advertising, she oversaw a global team of 500 professionals, gaining deep expertise in client services and executive leadership. With 25+ years of experience, Belinda is a trusted advisor to startups, turnarounds, acquisitions, and Fortune 500 companies, delivering strategic, high-impact solutions in today's fast-evolving business landscape.   Website: Belindapruyne.com Email Address: hello@belindapruyne.com LinkedIn: https://www.linkedin.com/in/belindapruyne  Facebook: https://www.facebook.com/NotableLeadersNetwork.BelindaPruyne/  Twitter: https://twitter.com/belindapruyne?lang=en  Instagram: https://www.instagram.com/belindapruyne/ 

I am so excited to say that my guest on the GWA Podcast is the brilliant New York based painter, Katherine Bradford. Hailed for her luminous paintings of swimming pools and cosmic skies, ballet dancers and bicycle riders, Bradford takes us to imaginary worlds full of freedom, togetherness and wonder. Not usually specifying the figures in her work, instead she offers us a universal depiction of humanity – that any of us can apply ourselves or relate to – playing with scale and perspective, and getting us to think hard about our place on this earth. Born in 1942, and raised in Connecticut, Bradford didn't always start off as an artist. A woman of stifling 1960s America, she was married with twins in her 20s, but aged 37, swapped this life, bringing her kids along, to become an artist in New York City, and never looked back. Making her way by teaching from the 1980s to the 2010s, becoming the senior critic on the faculty of Yale School of Art and being awarded Pollock Krasner grants and Guggenheim Fellowships, Bradford – although painting for decades – has received major recognition in the past decade, such as her recent survey show at the Portland Museum of Art. And thank goodness she carried on painting, because especially at a time like this, of despair and uncertainty, we can look to Bradford's paintings for hope, visualisations of freedom that prioritise inclusiveness and community – as she has said: “It's important to me to make upbeat paintings. If anything, I'm making paintings about enchantment.” Looking at Bradford's painting is like being transported into another world, whether it be outer space or in cosmic waters, it's like they are lit with a glow akin to a blanket of stars. There is nothing artificial about them: they are spellbinding, and her canvases become a springboard for the most magical scenes, an “intentional place for imagination” as she says “as they convey a personal universe of my own making, populated with characters who explore who we are, how we fit together visually, and how we all stand next to each other.” -- THIS EPISODE IS GENEROUSLY SUPPORTED BY THE LEVETT COLLECTION: https://www.famm.com/en/ https://www.instagram.com/famm_mougins // https://www.merrellpublishers.com/9781858947037 Follow us: Katy Hessel: @thegreatwomenartists / @katy.hessel Sound editing by Nada Smiljanic Music by Ben Wetherfield

Today, we're excited to get to know Dr. Ali Khan, Chief Medical Officer of Aetna Medicare, overseeing healthcare services for over 4 million members. His career spans across some of the most impactful value-based care organizations, including Oak Street Health, CareMore, and Iora Health. He is also an adjunct lecturer at Northwestern University's Kellogg School of Management and serves on the clinical faculty of the Yale School of Medicine. Additionally, Dr. Khan is a director on the American Board of Internal Medicine. Also a trusted advisor on Pear's Health Industry Council.Before Aetna, Dr. Khan played a key role in Oak Street Health's rapid expansion, scaling it from 21 to 200+ clinics, culminating in its acquisition by CVS Health. Prior to that, he was instrumental in CareMore Health's growth and innovation in care delivery for vulnerable populations.He holds an MD-MPP from Virginia Commonwealth University and Harvard Kennedy School, completed his residency at Yale, and has taught at institutions like Northwestern Kellogg and Yale School of Medicine.As a leader in value-based care, he has firsthand experience in building, scaling, and optimizing healthcare startups—making his insights invaluable for founders, investors, and industry leaders navigating the complex world of healthcare innovation.

“I've given away all my cards. I'm f*ggy online.” This week, the gals interview actor-writer-comedian ("the most definite multi-hyphenate in the world") Tarek Ziad -- he is a wonderful wonderful creative genius, he went to the Yale School of Drama (ever heard of Meryl Streep?), and he has MUCH to share!We release two types of episodes -- interviews (that's this one!) and pop culture/reality TV chats. If you wanna hear Ann and Amanda talk reality TV, check out last weeks DeSorbo v. Conover episode!Check out:Tarek's socials: @tarekaziadTarek's substack: Perfect InformationWSANDA SUBMISSIONS: wsandasubmissions@gmail.comFollow us on instagram @wesignedannda @mikiannmaddox @liffordthebigreddog so you can slither in our DMs with constructive feedback, but please, for the love of god, don't cyberbully us. We're fragile :-/If you're picking up what we're putting down and want even more Ann and Amanda comedy content, support us on Patreon. You have no idea how many times we've said "Wait, this is too batshit.....we'll put it on Patreon." Our cover art was made by America's sweetheart, producer Maddy, and our theme song features parts of "Kawaii Til I Die" by Starjunk 95 Hosted on Acast. See acast.com/privacy for more information.

In this episode of 'Inspire to Lead,' host Talia Mashiach interviews Dr. Sharon Stoll, a board-certified neurologist and neuroimmunologist from Philadelphia. Sharon discusses her upbringing, her unwavering passion for medicine despite societal discouragement, and how she navigated through medical school and residency while managing family life. She shares the pivotal role her supportive husband played in her success and addresses the challenges and triumphs of balancing a demanding career with motherhood. The conversation also delves into the expectations placed on Jewish women in their communities and the importance of pursuing fulfilling careers to maintain overall happiness and effectiveness as both mothers and wives. Sharon's story is an inspiring testament to resilience, determination, and the impact of supportive relationships.   00:00 Introduction to Inspire to Lead Podcast 00:29 Meet Sharon Stoll: A Journey to Medicine 02:38 Balancing Media and Medicine 08:44 Personal Life and Family Dynamics 15:15 Navigating Career and Marriage 37:12 Parenting in Modern Times 39:14 Balancing Career and Family Aspirations 42:43 The Journey to Motherhood 43:16 Navigating Medical School and Motherhood 54:24 Support Systems and Community 01:01:46 Reflections and Advice 01:16:09 Biggest Accomplishments and Lessons Learned     About Dr. Sharon Stoll: Dr. Sharon Stoll is a board-certified neurologist, neuro-immunologist. She currently serves as Director of Neurology at Stoll Medical Group in Philadelphia. For the past 8 years she worked as assistant professor, in the department of neurology at Yale School of Medicine. She completed her neurology residency training at Thomas Jefferson University Hospital in Philadelphia and her Neuroimmunology fellowship at Yale New Haven Hospital. Dr. Stoll played an active role in academic development and continuing medical education. She currently serves on several steering committees and advisory boards. She has been published in numerous peer-reviewed journals and served as Principal Investigator on several clinical trials. Dr. Stoll has received numerous awards, including Top Neurologist, 40 under 40, the Rodney Bell teaching award, and is a national multiple sclerosis society grant recipient. Dr. Stoll is also a medical editor for Medscape and Healthline and previously worked as a medical editor for ABC News. She is also a medical commentator for several national and local news outlets, including ABC, NBC, and CBS News, and has been on a variety of shows, including “The Doctors”. She is an internationally renowned speaker and patient advocate. https://www.drsharonstoll.com   Powered By Roth & Co The JWE For guest suggestions, please email Talia: podcast@thejwe.org

NBC Sports Boston's Trenni Casey discusses the launch of the first US professional women's 15s rugby league and a controversy surrounding influencers and hot yoga. Harvard security expert Juliette Kayyem discusses the justice department seeking the death penalty for Luigi Mangione and the results of Tuesday's supreme court election in Wisconsin.Jeffrey Sonnenfeld of Yale School of Management discusses Trump's "liberation day" tariffs and the response (or lack-thereof) by CEOs to the Trump administration.Naturalist Sy Montgomery explains how urban spiders build soundproofing into their webs and why an octopus hitched a ride on a shark.

Here are 3 big things you need to know—   One — Polls will be open in Wisconsin and Florida today in what's being seen as a national political power struggle.  In Wisconsin there's a state supreme court election, and Florida voters will decide two pivotal vacant House seats that could shift the balance of power nationally.  Both sides see the  races as a referendum on the direction of the country since Donald Trump's election victory.   Two ---- The bodies of three of the four missing U.S. Army soldiers in Lithuania have been found.   The soldiers went missing during a training mission last week.  The M88 Hercules armored recovery vehicle they were in was lifted out of a swamp earlier today. The search continues for the fourth soldier.   And number three —   A recent study finds that a lack of sleep can lead to an increased risk of developing Alzheimer's disease.  The lead author of the study from Yale School of Medicine says if the brain doesn't spend sufficient time in deep sleep it can lead to shrinkages in certain parts of the brain affecting specific functions over time.  Adults typically need up to eight hours of sleep a night.

We want leaders to do the right thing when tested, and we want and believe we will rise to the challenge when the moment presents itself. But the current way we learn how to act ethically in those critical moments doesn't always translate or cause us to think we can do it effectively and confidently. Why not? How can we better prepare ourselves and our leaders when the moment arises? This is that episode. Giving Voice to Values (GVV) is an innovative approach to values-driven leadership development in business education and the workplace. Drawing on actual experience and scholarship, GVV fills a long-standing critical gap in the development of values-centered leaders. It's not about persuading people to be more ethical. Rather GVV starts from the premise that most of us already want to act on our values, but that we also want to feel that we have a reasonable chance of doing so effectively and successfully. In this episode we'll explore how to raise those odds.***ABOUT OUR GUEST:Mary C. Gentile, PhD,  is Creator and Director of Giving Voice to Values (www.GivingVoiceToValuesTheBook.com), launched with The Aspen Institute and Yale School of Management and hosted at Babson College for 6 years, now based at UVA-Darden. This values-driven leadership curriculum has been piloted and/or presented in over 1,500 sites globally and has been featured in Financial Times, Harvard Business Review, Stanford Social Innovation Review, McKinsey Quarterly, etc. Gentile is a consultant, speaker and author on GVV. She was formerly the Richard M. Waitzer Bicentennial Professor of Ethics at UVA Darden  (2016-2022) and was previously at Harvard Business School (1985-95) and Babson College (2009—2015). She holds a B.A. from The College of William and Mary and Ph.D. from State University of New York-Buffalo.Gentile's publications include: Giving Voice to Values: How To Speak Your Mind When You Know What's Right; Can Ethics Be Taught? Perspectives, Challenges, and Approaches at Harvard Business School (with Thomas Piper & Sharon Parks); Differences That Work: Organizational Excellence through Diversity; Managerial Excellence Through Diversity: Text and Cases, as well as cases and articles in Harvard Business Review, Stanford Social Innovation Review, Academy of Management Learning and Education, Risk Management, CFO, BizEd, Strategy+Business, and others. Gentile was Content Expert for the award-winning CD-ROM, Managing Across Differences (Harvard Business School Publishing). ***IF YOU ENJOYED THIS EPISODE, CAN I ASK A FAVOR?We do not receive any funding or sponsorship for this podcast. If you learned something and feel others could also benefit, please leave a positive review. Every review helps amplify our work and visibility. This is especially helpful for small women-owned boot-strapped businesses. Simply go to the bottom of the Apple Podcast page to enter a review. Thank you!***LINKS MENTIONED IN EPISODE:www.gotowerscope.comwww.GivingVoiceToValuesTheBook.com#GivingVoicetoValues, #TheHardSkills #LeadershipDevelopment #LeadershipValues #ValuesDrivenLeadershipTune in for this empowering conversation at TalkRadio.nyc

What if the institutions we rely on—our workplaces, schools, and legal systems—aren't built for full participation? And what if real change starts not from the top, but in small, intentional spaces we create ourselves? In this episode Heidi Brooks and legal scholar and change-maker Susan Sturm explore the paradoxes of institutional transformation, and how facing uncertainty–rather than seeking to eliminate it–can create new possibilities for participation, collaboration and justice.  Drawing from her new book, What Might Be: How Universities and Other Institutions Can Change, Susan shares how we can confront the tensions within our systems—between power and powerlessness, justice and exclusion, certainty and humility—without rushing to resolve them. Through personal stories and deep insights, she introduces the concept of micro spaces of justice—small but intentional environments where people model the institutional change they wish to see. These spaces, she argues, offer a path forward amid today's polarization and institutional inertia.  This episode invites listeners to rethink their role in shaping institutions, reimagining power, and embracing paradox as a source of transformation. Listen now and join the conversation on what might be possible. Learning Through Experience is produced through the Yale School of Management. What resonates with you about this conversation? We'd love to hear from you—reach out to LTEpodcast@yale.edu. And subscribe to the monthly LinkedIn newsletter for additional insights and reflections about episode topics and questions to ponder.  Watch this episode on YouTube. Resources

March is National Sleep Awareness Month, and in this Think Thursday episode, we're revisiting one of the most overlooked—but absolutely essential—pillars of brain health: sleep.Molly shares compelling new research from a December 2024 Yale School of Medicine study showing that sleeping too much or too little is linked to measurable brain changes that can precede stroke and dementia. If you're working to change your drinking habits or build better behaviors, understanding the role of sleep in neuroplasticity is critical.This episode unpacks the science behind sleep and habit change, especially how sleep disruption—often caused by alcohol—can interfere with your ability to rewire your brain. You'll walk away with science-backed tools to make better sleep part of your alcohol minimalist journey.In This Episode You'll Learn:How neuroplasticity is strengthened during sleepWhy 7 to 9 hours of sleep is the “sweet spot” for brain healthWhat white matter hyperintensities and fractional anisotropy reveal about long-term cognitive risksHow alcohol interferes with deep and REM sleep, increasing cortisol and reducing emotional resiliencePractical ways to improve your sleep and support your behavior change goalsScientific Insight“Sleeping too much or too little is associated with silent brain injuries that clinicians know to foreshadow stroke and dementia years before their onset.” — Journal of the American Heart Association, December 2024Key TakeawaysAim for 7 to 9 hours of sleep per night to optimize brain function and long-term healthConsider sleep a core pillar of your wellness strategy, alongside mindful drinking and thought workUnderstand the reinforcing relationship between reducing alcohol and improving sleep qualityTake small, consistent steps to support better sleep—start by limiting screens or swapping a nightly drink for herbal teaResources and LinksListen to the original Think Thursday episode on sleep and neuroplasticity (September 2024) https://pdst.fm/e/dts.podtrac.com/redirect.mp3/media.transistor.fm/6e94ccc6/85d6d4a2.mp3Explore Alcohol Minimalist programs like Making Peace with Alcohol www.mollywatts.com/workwithmeSupport the ShowIf this episode was helpful, please take a moment to rate and review the podcast. Your support helps more people discover the science-based, judgment-free work of the Alcohol Minimalist.Closing Message Sleep well. Think better. Keep choosing peace. ★ Support this podcast ★

Millions of American women use some form of contraception to prevent pregnancy, and one of the most popular forms is an intrauterine device, or IUD. Lately, IUDs have been going viral not because of their popularity, but because of the pain associated with getting them. Ali Rogin speaks with Dr. Aaron Lazorwitz, a professor at Yale School of Medicine, to learn more. PBS News is supported by - https://www.pbs.org/newshour/about/funders

My guest today is Joshua Rosenblum, author of Closer than Ever — The Unique Six-Decade Songwriting Partnership of Richard Maltby, Jr. and David Shire. This terrific new book chronicles the sixty-six-year (and counting) partnership of two of the most gifted songwriters of our time, giving full behind-the-scenes accounts of their musicals interspersed with deep-dive analyses of standout individual numbers. Among the well-known Broadway figures who feature prominently in the Maltby/Shire story are Stephen Sondheim, Hal Prince, Michael Stewart, Francis Ford Coppola, Susan Stroman, John Weidman, Charles Strouse, Garth Drabinsky, Jason Robert Brown, and Jonathan Tunick. Using his experiences as a Broadway conductor, music journalist, and professor of musical theater composition, as well as his long-term personal and professional acquaintance with both Maltby and Shire, Joshua Rosenblum is uniquely suited to chronicle their lives, careers, and creative output. The songwriters, both of whom are engaging and articulate in describing what they do, are quoted liberally throughout the book in exclusive interviews, creating the impression that one is spending time with two inspiring creative artists who happen to be great company.   Joshua Rosenblum teaches Composing for Musical Theater at Yale University and Conducting at New York University. As a composer/lyricist, he wrote the scores to the off-Broadway musicals Fermat's Last Tango, Bush is Bad, and Einstein's Dreams (four Drama Desk Nominations). He has conducted fourteen Broadway and off-Broadway shows and has performed as pianist with the New York Pops at Carnegie Hall, the City Center Encores! Orchestra, and the American Symphony. A longtime contributor of reviews and features to Opera News, Rosenblum is a summa cum laude graduate of Yale College and holds a master's degree in Piano from the Yale School of Music. Become A PATRON of Broadway Nation! This episode is made possible in part through the generous support of our Patron Club Members such as John Schroeder. If you are a fan of Broadway Nation, I invite you to become a PATRON! For as little as $7.00 a month you can receive exclusive access to never-before-heard, unedited versions of many of the discussion that I have with my guests — in fact I often record nearly twice as much conversation as ends up in the edited versions. And you will also have access to additional in-depth conversations with my frequent co-host Albert Evans that have not been featured on the podcast. And all patrons receive special “on-air” shout-outs and acknowledgement of your vital support of this podcast. And If you are very enthusiastic about Broadway Nation there are additional PATRON levels that come with even more benefits. If you would like to support the work of Broadway Nation and receive these exclusive member benefits, please just click on this link: https://broadwaynationpodcast.supercast.tech/ Thank you in advance for your support! Learn more about your ad choices. Visit megaphone.fm/adchoices

Ukraine says tens of thousands of children have been taken and illegally hidden within Russia’s adoption system since the invasion. A lab at the Yale School of Public Health that had been tracking this fell victim to the Trump administration’s foreign aid cuts Dina Ament spent about four years remodeling her historic Tudor-style cottage. After the Eaton Fire leveled it, she at first wanted to rebuild, but ultimately decided that selling was best. Part play, part rock concert, "Cambodian Rock Band" is a story of survival. Playwright Lauren Yee explores Cambodia's dark past with music and humor. Microgravity, confined quarters, and heightened galactic radiation lead to physiological changes in humans. What we’re learning in space is influencing terrestrial health care. 

In a world where public health messages often clash with sensational media coverage, Dr. Harvey Risch, a professor emeritus at Yale School of Public Health, provides a refreshing perspective on the current health landscape. Dr. Risch delves into the current state of bird flu and measles outbreaks, exploring the risks to the general public and discussing the implications of vaccination strategies. Dr. Risch shares his insights on how to approach these health concerns rationally and the importance of transparency in public health communications. Also, Dr. McCullough, the chief scientific officer at the Wellness Company, discusses the alarming rise of bird flu and its potential for human transmission. Dr. McCullough shares his insights on the current state of the outbreak, the counterproductive nature of culling, and the importance of natural immunity. He also delves into the resurgence of measles, exploring the implications of recent fatalities and the need for thorough public health investigations. Finally, Media Research Center's executive director, Dan Schneider, breaks down the pressing issue of censorship in America, unravelling the extensive censorship initiatives launched during the Biden administration, explore the implications of government influence on media, and discuss the ongoing campaign to defund taxpayer-supported media outlets like PBS and NPR. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

First up, Ralph welcomes former FBI agent Mike German to discuss his new book (co-written with Beth Zasloff), Policing White Supremacy: The Enemy Within. Then, Ralph speaks to Dr. Bandy Lee about her psychological analysis of the second Trump presidency. Finally, Ralph talks about Trump's latest Congressional address.Mike German is a fellow with the Liberty and National Security program at the Brennan Center for Justice at NYU Law School. He has worked at the ACLU and served sixteen years as an FBI special agent. He left the FBI in 2004 after reporting continuing deficiencies in the bureau's counterterrorism operations to Congress. He is the author of Thinking Like a Terrorist, Disrupt, Discredit, and Divide: How the New FBI Damages Our Democracy, and his latest book (co-authored with Beth Zasloff) is Policing White Supremacy: The Enemy Within.It's important to understand that the white supremacist movement is quite fractured and I refer to it in the book as the white supremacist and far right militant movement because it does have a number of different factions that have specific goals that in many cases differ from one another. But as a movement, essentially what they're looking for is a return to a legally-supported racial caste system where white people dominate without question and impunity to act violently towards anyone who would challenge that racial hierarchy.Mike GermanIt's fascinating because I think there's an assumption that many have that these white supremacists or far-right militant groups are Trump supporters, but I don't believe many of them are. They understand that right-wing populism, that those racist (I would have said “dog whistles” of previous administrations, but racist) rhetoric helps promote them and gives them media attention that allows them to recruit and expand their ranks. But they don't support Donald Trump. They don't support the Republican Party.Mike GermanYou have a situation now where these people that led the movement into a ditch on January 6th (and they had to scramble and all go underground and then slowly restore these groups) all of a sudden these people who led them into the ditch come out ofprison and want to be the leaders again.Mike GermanThere comes a time when the flattering of the citizens by rogue criminal politicians has got to be exposed for what it is. First, they flatter the citizenry, then they flummox the citizenry, then they fool the citizenry into supporting them. And the reaction to that has got to be: you'd better start doing your homework, voters, regardless who you vote for. You've got to spend more time on the records of these politicians, not their rhetoric.Ralph NaderDr. Bandy Lee is a medical doctor, a forensic psychiatrist, and a world expert on violence who taught at Yale School of Medicine and Yale Law School for 17 years before joining the Harvard Program in Psychiatry and the Law. She is currently president of the World Mental Health Coalition, an educational organization that assembles mental health experts to collaborate with other disciplines for the betterment of public mental health and public safety. She is the editor of The Dangerous Case of Donald Trump: 37 Psychiatrists and Mental Health Experts Assess a President and Profile of a Nation: Trump's Mind, America's Soul.This is a problem of mental pathology. That is why [Trump] has to place mental health labels on his opponents, why he has to call himself a stable genius, and why he has to take on the most powerful position on the planet (the US presidency). It is to hide his unfitness and his mental pathology. That's what it comes down to.Dr. Bandy Lee[Trump's] been in the public arena and influential positions for a decade now, but we have to address it in mental health terms. His goal is to alter reality and through threats, intimidation and co-optation, he has not only taken over the press and is in the process of buying it out, but he has also subdued…corrupted the Supreme Court and the Congress, and he has figured out that with the speed with which he is wreaking his havoc, by the time courts can respond, the agencies that held our society together will be gutted, closed, and changed forever.Dr. Bandy Lee Get full access to Ralph Nader Radio Hour at www.ralphnaderradiohour.com/subscribe