Focus on Neurology and Psychiatry

Host: Barry A. Singer, MD Patients living with MS can experience hidden or invisible symptoms that may not be apparent to others but can affect how they feel and function. In this podcast, Dr. Barry Singer, the Director at the Multiple Sclerosis Center for Innovations in Care, and Rosario, a patient who has been living with MS for 10 years, discuss their clinical and personal experiences with MS, and the impact that MS can have on a patient's QoL. In the 2-year AFFIRM pivotal trial: Relapsing MS patients received 300 mg TYSABRI every 28 days (n=627) or placebo (n=315). Patients with PPMS, SPMS, and PRMS were excluded.2,3 83% of patients taking TYSABRI had no sustained disability progression for 12 weeks vs 71% with placebo (primary endpoint: 17% vs 29%; p

Host: Jacqueline Nicholas, MD, MPH Ever had a multiple sclerosis (MS) patient who needed to start a DMT? Listen to Dr. Jacqueline Nicholas, System Chief of Neuroimmunology and Director of MS Research at Ohio Health, and Kim, a patient who has been living with MS for seven years, share their experiences with the treatment decision process, including benefit-risk considerations, treatment goals, and patient preferences. They talk about the process for starting and continuing treatment with TYSABRI® (natalizumab) and how Biogen Support Services can help. Please see Important Safety Information, including Boxed Warning for PML, below.

Guest: Caroline Hastings, MD Guest: Raymond Y. Wang, MD Niemann-Pick disease type C (NPC) is an ultra-rare, inherited, neurodegenerative disease with life-threatening complications. Due to its highly variable onset of neurological symptoms throughout one's lifespan, recognizing and establishing diagnosis for NPC can be challenging for any clinician. That's why Drs. Caroline Hastings and Raymond Y. Wang join Dr. Jennifer Caudle to help address those challenges with a detailed look at this genetic condition, the factors underlying its variable onset and course, and strategies to improve recognition, cross-specialty communications, and time to diagnosis. Copyright ©2021 Orphazyme A/S. All rights reserved.NP-USA-1492-v1ORPHAZYME is a trademark or registered trademark of Orphazyme A/S.

Guest: Timothy William West, MD Here to discuss staying ahead of progression in patients with relapsing multiple sclerosis (RMS) is Dr. Timothy William West. Dr. West walks us through pathophysiological changes in progressing RMS patients, a patient case demonstrating why patients may experience increasing disability, and key data on MAYZENT®(siponimod), the first and only oral disease-modifying therapy studied and proven to delay disability progression in a more progressed RMS patient population. MAYZENT was evaluated in EXPAND—the largest Phase III study of secondary progressive MS (SPMS) patients to date (N=1651), which included a broad range of patients with moderate-to-advanced disability. Dr. West discusses clinical data from EXPAND including data of up to 5 years from a preplanned interim analysis of the EXPAND open-label extension study.

Guest: Timothy William West, MD Here to discuss staying ahead of progression in patients with relapsing multiple sclerosis (RMS) is Dr. Timothy William West. Dr. West walks us through pathophysiological changes in progressing RMS patients, a patient case demonstrating why patients may experience increasing disability, and key data on MAYZENT®(siponimod), the first and only oral disease-modifying therapy studied and proven to delay disability progression in a more progressed RMS patient population, including active SPMS. MAYZENT was evaluated in EXPAND—the largest Phase III study of secondary progressive MS (SPMS) patients to date (N=1651), which included a broad range of patients with moderate-to-advanced disability. Dr. West discusses clinical data from EXPAND including data of up to 5 years from a preplanned interim analysis of the EXPAND open-label extension study.

Host: Jennifer Caudle, DO Guest: Kathleen Blake, MD, MPH Guest: Peggy Chen, MD Behavioral health integration has proven to be an effective solution to improving access to treatment for many mental health conditions… So why is it not more prevalent in the medical community? Joining Dr. Jennifer Caudle to dive into the findings and implications of the joint AMA-RAND Corporation study recently published in the Annals of Internal Medicine are Dr. Kathleen Blake with the AMA and Dr. Peggy Chen from the RAND Corporation. And, click here to listen to a conversation regarding Behavioral Health Integration and its effect on clinical practice.

Host: Jennifer Caudle, DO Guest: Kathleen Blake, MD, MPH Guest: Peggy Chen, MD Behavioral health integration has proven to be an effective solution to improving access to treatment for many mental health conditions… So why is it not more prevalent in the medical community? Joining Dr. Jennifer Caudle to dive into the findings and implications of the joint AMA-RAND Corporation study recently published in the Annals of Internal Medicine are Dr. Kathleen Blake with the AMA and Dr. Peggy Chen from the RAND Corporation. And, click here to listen to a conversation regarding Behavioral Health Integration and its effect on clinical practice.

Guest: Andrew Cutler, MD In Chapter 1 of this three-part series that’s designed to help increase the awareness and understanding of the pathophysicology and comorbidities in patients with bipolar disorder or schizophrenia, Dr. Cutler explores the pathophysicology and some comorbidities in patients with bipolar disorder. This is an informational non-CME program sponsored by Alkermes, Inc. ALKERMES® is a registered trademark of Alkermes, Inc. KEEP THE BODY IN MIND® is a registered service mark of Alkermes Pharma Ireland Limited, used by Alkermes, Inc., under license. ©2020 Alkermes, Inc. All rights reserved. None of the subjects pictured are actual patients. UNB-002745

Guest: Andrew Cutler, MD Take a closer look at the pathophysiology of schizophrenia and a range of physical comorbidities with Dr. Cutler in Chapter 2 of this three-part series for the “Keep the Body in Mind” initiative. This is an informational non-CME program sponsored by Alkermes, Inc. ALKERMES® is a registered trademark of Alkermes, Inc. KEEP THE BODY IN MIND® is a registered service mark of Alkermes Pharma Ireland Limited, used by Alkermes, Inc., under license. ©2020 Alkermes, Inc. All rights reserved. None of the subjects pictured are actual patients. UNB-002974

Guest: Andrew Cutler, MD In the third and final chapter of this series for the “Keep the Body in Mind” initiative, Dr. Cutler discusses strategies that could improve care for patients with bipolar disorder or schizophrenia and talks about recommendations for evaluating and monitoring health conditions. This is an informational non-CME program sponsored by Alkermes, Inc. ALKERMES® is a registered trademark of Alkermes, Inc. KEEP THE BODY IN MIND® is a registered service mark of Alkermes Pharma Ireland Limited, used by Alkermes, Inc., under license. ©2020 Alkermes, Inc. All rights reserved. None of the subjects pictured are actual patients. UNB-002975

Host: Mario R. Nacinovich, Jr., MSc Guest: Paul Orchard, MD Although it only affects about one in 18,000 people, the impacts of adrenoleukodystrophy cannot be underestimated. That's why Dr. Paul Orchard joins Mario Nacinovich to talk about this rare—and fatal—genetic disease, why it's often underdiagnosed and confused with other conditions, and how we can treat it once we've reached an accurate diagnosis.

Host: Mario R. Nacinovich, Jr., MSc Guest: Paul Orchard, MD Although it only affects about one in 18,000 people, the impacts of adrenoleukodystrophy cannot be underestimated. That’s why Dr. Paul Orchard joins Mario Nacinovich to talk about this rare—and fatal—genetic disease, why it’s often underdiagnosed and confused with other conditions, and how we can treat it once we’ve reached an accurate diagnosis.

Host: Mimi Secor, DNP, FNP-BC, FAANP Guest: James B, Potash, MD, MPH Psychopharmacology is the study of genetic variations to pinpoint more effective personalized treatments for psychiatric disorders. But with clinicians, industry heads, insurance providers, and regulating agencies all weighing in on this practice and forming varying opinions, what’s the best way to move forward? Here to answer that question and others with Dr. Mimi Secor is Dr. James Potash, a Professor of Psychiatry and Behavioral Sciences and Psychiatrist in Chief at the John Hopkins Department of Psychiatry.

Host: Brian P. McDonough, MD, FAAFP Guest: Kisma Orbovich Improvement is something we're all constantly chasing, whether it's in the form of a promotion, a bigger house, or maybe even an ideal weight. So why do we often fail miserably at these attempts to make our lives better? To get to the bottom of this dilemma, Dr. Brian McDonough is joined by Kisma Orbovich, the CEO of Illumination Academy, to reveal the secret to true success and how gratitude may just be the lifehack we've been searching for.

Host: Brian P. McDonough, MD, FAAFP Guest: Kisma Orbovich Improvement is something we’re all constantly chasing, whether it’s in the form of a promotion, a bigger house, or maybe even an ideal weight. So why do we often fail miserably at these attempts to make our lives better? To get to the bottom of this dilemma, Dr. Brian McDonough is joined by Kisma Orbovich, the CEO of Illumination Academy, to reveal the secret to true success and how gratitude may just be the lifehack we’ve been searching for.

Host: Brian P. McDonough, MD, FAAFP Guest: Teresa Gil, PhD Since about 21 million mothers in America experienced sexual abuse in their childhood, there's a good chance that some of these women are our patients. So as their physicians, how can we provide them with the best possible care as they continue to cope with the lifelong effects of sexual abuse? That's what Dr. Brian McDonough explores with Dr. Teresa Gil, author of Women Who Were Sexually Abused as Children: Mothering, Resilience, and Protecting the Next Generation.

Host: Brian P. McDonough, MD, FAAFP Guest: Teresa Gil, PhD Since about 21 million mothers in America experienced sexual abuse in their childhood, there’s a good chance that some of these women are our patients. So as their physicians, how can we provide them with the best possible care as they continue to cope with the lifelong effects of sexual abuse? That’s what Dr. Brian McDonough explores with Dr. Teresa Gil, author of Women Who Were Sexually Abused as Children: Mothering, Resilience, and Protecting the Next Generation.

Host: Patricia K. Coyle, MD Guest: Clyde E. Markowitz, MD Please note: This activity is no longer available for continuing education credit. Multiple sclerosis (MS) is one of the leading causes of disability worldwide. As the treatment armamentarium continues to grow, patient involvement in the development of an effective treatment strategy is becoming increasingly important. In this Clinical ExchangesSM activity, leading MS specialists discuss issues of diagnosing MS, initiating treatment, and switching therapies, all in the context of practical shared decision-making techniques demonstrated by their own patients.

Host: Patricia K. Coyle, MD Guest: Clyde E. Markowitz, MD Please note: This activity is no longer available for continuing education credit. Multiple sclerosis (MS) is one of the leading causes of disability worldwide. As the treatment armamentarium continues to grow, patient involvement in the development of an effective treatment strategy is becoming increasingly important. In this Clinical ExchangesSM activity, leading MS specialists discuss issues of diagnosing MS, initiating treatment, and switching therapies, all in the context of practical shared decision-making techniques demonstrated by their own patients.

Host: Andrew Wilner, MD, FACP, FAAN As a follow-up to the Microgravity: A New Risk Factor for Idiopathic Intracranial Hypertension essay he wrote back in 2012, Dr. Andrew Wilner investigates whether there have been any updates on the 27 astronauts who had significant microgravity exposure.

Host: Andrew Wilner, MD, FACP, FAAN Even with quick thinking and timely action, the chances of a neurosurgeon being able to do more than taking out the bullet, administering antibiotics, and stopping the bleeding isn't likely, and surviving a bullet to the brain can unfortunately be just the beginning of a patient's struggles. Focusing on the title story of his book Bullets and Brains, Dr. Andrew Wilner discusses the serious aftermath congresswoman Gabrielle Giffords experienced while recovering from a headshot.

Host: Andrew Wilner, MD, Author of "The Locum Life: A Physician's Guide to Locum Tenens" As a follow-up to the Microgravity: A New Risk Factor for Idiopathic Intracranial Hypertension essay he wrote back in 2012, Dr. Andrew Wilner investigates whether there have been any updates on the 27 astronauts who had significant microgravity exposure.

Host: Andrew Wilner, MD, Author of "The Locum Life: A Physician's Guide to Locum Tenens" Even with quick thinking and timely action, the chances of a neurosurgeon being able to do more than taking out the bullet, administering antibiotics, and stopping the bleeding isn’t likely, and surviving a bullet to the brain can unfortunately be just the beginning of a patient’s struggles. Focusing on the title story of his book Bullets and Brains, Dr. Andrew Wilner discusses the serious aftermath congresswoman Gabrielle Giffords experienced while recovering from a headshot.

Host: Matt Birnholz, MD Guest: Wes Ely, MD, MPH After surviving a critical illness, many patients look forward to their lives returning to normal, but unfortunately, that's not always possible. To uncover the far-reaching impacts of delirium, Dr. Matt Birnholz is joined by Dr. Wes Ely, Professor of Medicine and Co-Director of the Center for Critical Illness, Brain Dysfunction and Survivorship Center at Vanderbilt University's School of Medicine which focuses on improving the lives and care of patients in the intensive care unit to ensure both physical and cognitive rehabilitation.

Host: Matt Birnholz, MD Guest: Wes Ely, MD, MPH After surviving a critical illness, many patients look forward to their lives returning to normal, but unfortunately, that’s not always possible. To uncover the far-reaching impacts of delirium, Dr. Matt Birnholz is joined by Dr. Wes Ely, Professor of Medicine and Co-Director of the Center for Critical Illness, Brain Dysfunction and Survivorship Center at Vanderbilt University’s School of Medicine which focuses on improving the lives and care of patients in the intensive care unit to ensure both physical and cognitive rehabilitation.

Host: Brian P. McDonough, MD, FAAFP Guest: David Neagle Is it possible that our environment and experiences have subconsciously programmed our emotional response to the world around us? Joining Dr. Brian McDonough is David Neagle, author of The Millions Within: Tips to Improve Emotional Intelligence, to offer advice on what impacts our emotional intelligence and the changes we can implement to strengthen our own. Produced in cooperation with:

Host: Brian P. McDonough, MD, FAAFP Guest: David Neagle Is it possible that our environment and experiences have subconsciously programmed our emotional response to the world around us? Joining Dr. Brian McDonough is David Neagle, author of The Millions Within: Tips to Improve Emotional Intelligence, to offer advice on what impacts our emotional intelligence and the changes we can implement to strengthen our own. Produced in cooperation with:

Host: Brian P. McDonough, MD, FAAFP In a time when humans walked among wild animals, the fight-or-flight response could've been the difference between eating dinner or being dinner. Today, however, the effect of this stress could be much more problematic for our society. In a review of his findings, Dr. Pratha Dutta joins Dr. Brian McDonough to focus on how our body and immune system react to sympathetic activation and what this might mean for some of your patients.

Host: Brian P. McDonough, MD, FAAFP In a time when humans walked among wild animals, the fight-or-flight response could've been the difference between eating dinner or being dinner. Today, however, the effect of this stress could be much more problematic for our society. In a review of his findings, Dr. Pratha Dutta joins Dr. Brian McDonough to focus on how our body and immune system react to sympathetic activation and what this might mean for some of your patients.

Host: Maurice Pickard, MD Guest: Allison Pataki Five months pregnant, on a flight headed for Hawaii, Allison Pataki's life took a sudden turn when she witnessed her husband, Dave Levy, lose consciousness. After an emergency landing and evaluation, Levy was found to have had suffered a rare stroke. When he woke the next day, he had amnesia, leaving the young couple holding onto hope for recovery. True to form, Pataki began to write letters to her husband—letters that became the foundation for Beauty in the Broken Places: A Memoir of Love, Faith, and Resilience.

Host: Maurice Pickard, MD Guest: Allison Pataki Five months pregnant, on a flight headed for Hawaii, Allison Pataki's life took a sudden turn when she witnessed her husband, Dave Levy, lose consciousness. After an emergency landing and evaluation, Levy was found to have had suffered a rare stroke. When he woke the next day, he had amnesia, leaving the young couple holding onto hope for recovery. True to form, Pataki began to write letters to her husband—letters that became the foundation for Beauty in the Broken Places: A Memoir of Love, Faith, and Resilience.

Guest: Stephanie Nahas, MD Assessing patients is an important component to quickly treating the root cause of headache discomfort. Join Dr. Stephanie Nahas, Director of the Headache Medicine Fellowship Program at Thomas Jefferson University, as she provides ‘tools of the trade' to use when presenting patients with treatment options that are right for them. Rethinking Migraine is sponsored by Lilly. Content for this a non-certified educational series is produced and controlled by ReachMD. This series is intended for healthcare professionals only.

The Food and Drug Administration (FDA) is warning that the medicine lamotrigine (Lamictal) for seizures and bipolar disorder can cause a rare but very serious reaction that excessively activates the body's infection-fighting immune system. This can cause severe inflammation throughout the body and lead to hospitalization and death, especially if the reaction is not diagnosed and treated quickly. A link to the full communication detailing specific information for health care professionals and a list of FDA-approved GBCAs can be found at www.fda.gov/Drugs/DrugSafety Released 4/25/2018

The Food and Drug Administration (FDA) is warning that the medicine lamotrigine (Lamictal) for seizures and bipolar disorder can cause a rare but very serious reaction that excessively activates the body’s infection-fighting immune system. This can cause severe inflammation throughout the body and lead to hospitalization and death, especially if the reaction is not diagnosed and treated quickly. A link to the full communication detailing specific information for health care professionals and a list of FDA-approved GBCAs can be found at www.fda.gov/Drugs/DrugSafety Released 4/25/2018

Host: Brian P. McDonough, MD, FAAFP With a wide spectrum of symptoms, treating depression often becomes frustrating—not only for the patient, but for the primary care physician as well. Joining Dr. Brian McDonough is Dr. Paul Gross, founder of the TMS Center of Lehigh Valley, to address the difficulties of properly identifying depression. Throughout the discussion, Dr. Green also exposes the impactful therapy Transcranial Magnetic Stimulation (TMS), which has been linked to improving other diseases beyond depression.

Host: Brian P. McDonough, MD, FAAFP With a wide spectrum of symptoms, treating depression often becomes frustrating—not only for the patient, but for the primary care physician as well. Joining Dr. Brian McDonough is Dr. Paul Gross, founder of the TMS Center of Lehigh Valley, to address the difficulties of properly identifying depression. Throughout the discussion, Dr. Green also exposes the impactful therapy Transcranial Magnetic Stimulation (TMS), which has been linked to improving other diseases beyond depression.

Host: Maurice Pickard, MD Guest: Carl Hart, MD Carl Hart, who grew up in one of Miami's toughest neighborhoods, escaped a life of crime and drugs and avoided becoming one of the crack addicts he now helps treat as the Chair of the Department of Psychology at Columbia University. His landmark, controversial research is redefining our understanding of addiction and demonstrates how personal experience and scientific study can inform and validate each other for a deeper understanding of human behavior and addiction. Host Dr. Maurice Pickard talks with Dr. Hart, author of the book High Price, about the relationship between drugs and pleasure, choice, and motivation, both in the brain and in society. They explore how his research sheds new light on common ideas about race, poverty, and drugs, and explain why current policies are failing.

Host: Maurice Pickard, MD Guest: Carl Hart, MD Carl Hart, who grew up in one of Miami’s toughest neighborhoods, escaped a life of crime and drugs and avoided becoming one of the crack addicts he now helps treat as the Chair of the Department of Psychology at Columbia University. His landmark, controversial research is redefining our understanding of addiction and demonstrates how personal experience and scientific study can inform and validate each other for a deeper understanding of human behavior and addiction. Host Dr. Maurice Pickard talks with Dr. Hart, author of the book High Price, about the relationship between drugs and pleasure, choice, and motivation, both in the brain and in society. They explore how his research sheds new light on common ideas about race, poverty, and drugs, and explain why current policies are failing.

Host: Shira Johnson, MD Guest: Bennett Omalu, MD Many studies have demonstrated long-lasting and even permanent brain damage that can originate from just one concussion. With athletes suffering multiple repeated head traumas due to high-contact sports, the controversies over player safety and long-term health risks remain hot-button issues. Pathologist Dr. Bennett Omalu coined the term "CTE" and published the first evidence for chronic traumatic encephalopathy after autopsying American football players. In this second of a two-part interview, he shares his perspectives on CTE in athletes and the lifelong dangers of contact sports.

Host: Shira Johnson, MD Guest: Bennett Omalu, MD Many studies have demonstrated long-lasting and even permanent brain damage that can originate from just one concussion. With athletes suffering multiple repeated head traumas due to high-contact sports, the controversies over player safety and long-term health risks remain hot-button issues. Pathologist Dr. Bennett Omalu coined the term "CTE" and published the first evidence for chronic traumatic encephalopathy after autopsying American football players. In this second of a two-part interview, he shares his perspectives on CTE in athletes and the lifelong dangers of contact sports.

Host: Shira Johnson, MD Guest: Bennett Omalu, MD Chronic Traumatic Encephalopathy (CTE) is a degenerative brain disease found in athletes, military veterans, and others who experience repetitive brain trauma. Pathologist Dr. Bennett Omalu coined the term "CTE" and published the first evidence for this condition after autopsying American football players. Host Dr. Shira Johnson welcomes Dr. Omalu to share the story of his discovery and the medical, athletic, and public responses that followed.

Host: Shira Johnson, MD Guest: Bennett Omalu, MD Chronic Traumatic Encephalopathy (CTE) is a degenerative brain disease found in athletes, military veterans, and others who experience repetitive brain trauma. Pathologist Dr. Bennett Omalu coined the term "CTE" and published the first evidence for this condition after autopsying American football players. Host Dr. Shira Johnson welcomes Dr. Omalu to share the story of his discovery and the medical, athletic, and public responses that followed.