Podcasts about northwestern university feinberg school

Dr. Patel is the Chief of Cardiology at Vitruvian Health and a board-certified interventional and structural cardiologist. He attended medical school at the Emory University School of Medicine in Atlanta, Georgia, and completed his residency training in internal medicine at the University of California San Francisco in San Francisco, California. He earned his Master in Business Administration degree at Northwestern University-Kellogg School of Management in Evanston, Illinois.He also completed his fellowships in cardiology at the Northwestern University Feinberg School of Medicine in Chicago, Illinois, and then further trained in structural and interventional cardiology at the Emory University School of Medicine in Atlanta, Georgia.https://vitruvianhealth.com/services/heart-vascular

Dr. Patel is the Chief of Cardiology at Vitruvian Health and a board-certified interventional and structural cardiologist. He attended medical school at the Emory University School of Medicine in Atlanta, Georgia, and completed his residency training in internal medicine at the University of California San Francisco in San Francisco, California. He earned his Master in Business Administration degree at Northwestern University-Kellogg School of Management in Evanston, Illinois.He also completed his fellowships in cardiology at the Northwestern University Feinberg School of Medicine in Chicago, Illinois, and then further trained in structural and interventional cardiology at the Emory University School of Medicine in Atlanta, Georgia.https://vitruvianhealth.com/services/heart-vascular

Dr. Patel is the Chief of Cardiology at Vitruvian Health and a board-certified interventional and structural cardiologist. He attended medical school at the Emory University School of Medicine in Atlanta, Georgia, and completed his residency training in internal medicine at the University of California San Francisco in San Francisco, California. He earned his Master in Business Administration degree at Northwestern University-Kellogg School of Management in Evanston, Illinois.He also completed his fellowships in cardiology at the Northwestern University Feinberg School of Medicine in Chicago, Illinois, and then further trained in structural and interventional cardiology at the Emory University School of Medicine in Atlanta, Georgia.https://vitruvianhealth.com/services/heart-vascular

Send a textHow the body's internal circadian clocks regulate metabolism, energy balance, and health.TOPICS DISCUSSED:Master circadian clock in the brain: Light detection via retina entrains the suprachiasmatic nucleus, which coordinates body-wide rhythms; intrinsic period slightly deviates from 24 hours, allowing seasonal flexibility.Peripheral clocks in organs: Nearly all cells have autonomous clocks; liver and fat clocks rapidly adjust to feeding time, while brain clock aligns more tightly to light.Clock mutations and metabolism: Disrupting core clock genes (e.g., CLOCK, BMAL1) causes obesity, liver fat accumulation, and impaired insulin secretion without hyperinsulinemia.Timing of food intake: Eating the same high-fat calories during rest phase causes more weight gain than during active phase due to differences in energy dissipation.Modern disruptions (jet lag, shift work, blue light): Create desynchrony between brain and peripheral clocks, contributing to metabolic issues; late-night eating impairs glucose handling.Critical illness & feeding: Tube feeding at night (opposite natural cycle) induces rapid insulin resistance, highlighting mismatch costs.Hormone rhythms: Testosterone, glucocorticoids, and others peak at specific times; misalignment affects stress, reproduction, and metabolism.Weight loss drugs & maintenance: GLP-1 drugs reduce intake effectively, but regain involves neuroendocrine adaptations tied to brain clock pathways.ABOUT THE GUEST: Joseph Bass, MD, PhD is Chief of Endocrinology, Metabolism and Molecular Medicine at Northwestern University Feinberg School of Medicine, Director of the Center for Diabetes and Metabolism, and a leading researcher who pioneered the link between circadian clock genes and metabolic disorders including obesity and diabetes.RELATED EPISODE:M&M 237 | Circadian Biology: Genetics, Behavior, Metabolism, Light, Oxygen & Melatonin | Joseph TakahashiSupport the showHealth Products by M&M Partners: SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off. Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts

In this episode of the PRS Global Open Keynotes podcast, the team from Ann and Robert H. Lurie Children's Hospital of Chicago, Illinois discuss how free AI tools can be used to convert plastic surgical textbooks into podcasts. This episode discusses the following PRS Global Open article: "Source-grounded Artificial Intelligence–Driven Transfer of Plastic Surgery Textbooks to Podcasts: Creation of Content and Trainee Satisfaction" by Iulianna Taritsa, Parul Rai, Anitesh Bajaj, Hannah Soltani and Arun K. Gosain. Read it for free on PRSGlobalOpen.com: https://journals.lww.com/prsgo/fulltext/2025/12000/source_grounded_artificial_intelligence_driven.21.aspx Dr. Arun Gosain is Professor of Pediatric Plastic and Reconstructive Surgery at the Northwestern University Feinberg School of Medicine at the Ann and Robert H. Lurie Children's Hospital of Chicago, Illinois. Hannah Soltani is senior medical student at the Northwestern Feinberg School of Medicine. Dr. Lulianna Taritsa is a plastic surgery resident at the Cleveland Clinic. Your host, Dr. Damian Marucci, is a board-certified plastic surgeon and Associate Professor of Plastic Surgery at the University of Sydney in Australia. #PRSGlobalOpen; #KeynotesPodcast; #PlasticSurgery; Plastic and Reconstructive Surgery- Global Open

Join us this episode for a conversation with Linda Ehrlich-Jones, RN, PhD, Associate Director of the Center for Rehabilitation Outcomes Research at Shirley Ryan AbilityLab and a Research Professor in the Department of Physical Medicine & Rehabilitation at Northwestern University Feinberg School of Medicine. In this conversation we discuss the current state of the medical evidence for intervening on chronic pain in people living with spinal cord injury, with a focus on strategies that do not require drugs. The paper explaining the process is titled "Behavioral/Physical and Stimulation Interventions for Chronic Pain Following Spinal Cord Injury: A systematic review" published in Topics in Spinal Cord Injury Rehabilitation. In this paper Dr. Ehrlich-Jones discuss a systematic literature review that compared behavioral and complementary therapies with neuromodulation-based stimulation approaches for managing chronic neuropathic pain after SCI, including their evidence base, clinical feasibility, and implications for future treatment innovation. We invite you to listen in as Dr. Ehrlich-Jones gives a thorough current update on non-pharmacological pain management, and trust you will enjoy this episode.

Join us this episode for a conversation with Linda Ehrlich-Jones, RN, PhD, Associate Director of the Center for Rehabilitation Outcomes Research at Shirley Ryan AbilityLab and a Research Professor in the Department of Physical Medicine & Rehabilitation at Northwestern University Feinberg School of Medicine. In this conversation we discuss the current state of the art in medicine for chronic pain in people living with spinal cord injury (SCI), with a focus on care that does not require drugs. The paper explaining the process is titled "Behavioral/Physical and Stimulation Interventions for Chronic Pain Following Spinal Cord Injury: A systematic review" published in Topics in Spinal Cord Injury Rehabilitation. In this paper Dr. Ehrlich-Jones compared behavioral and complementary therapies with neuromodulation-based stimulation approaches for managing chronic neuropathic (or "nerve") pain after SCI. We invite you to listen in as Dr. Ehrlich-Jones gives a thorough current update on drug-free pain management, and trust you will enjoy this episode.

Saving Our Veterans: The Shocking New Trend In Military SuicideAfter decades of rising veteran suicide rates, new research has revealed a dramatic downward trend since the pandemic. While various outreach programs and expanded crisis resources appear to be working, experts are now racing to identify which specific initiatives are driving this life-saving shift. Our guests discuss how community partnerships and early intervention strategies are successfully reaching those most at risk.Guests: Jeffrey Howard, professor of public health, University of Texas at San Antonio; Todd Burnett, PsyD, acting executive director, VA Office of Suicide PreventionHost: Elizabeth Westfield Producer: Kristen Farrah   Masculine Depression: A Father's Journey Through Postpartum DepressionWhile conversations surrounding postpartum depression often focus on mothers, a significant number of men are also struggling with this condition – now recognized as paternal postpartum depression. Experts note that as fathers take on more active parenting roles, they face an increased risk of depression between three and six months after a child's birth. Dr. Sheehan Fisher explains the growing need for paternal mental health education and the vital resources available to help new dads navigate this challenging transition.Guests: Dr. Sheehan Fisher, associate professor of psychiatry and behavioral sciences, Northwestern University Feinberg School of MedicineHost: Greg JohnsonProducers: Kristen Farrah Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Masculine Depression: A Father's Journey Through Postpartum Depression While conversations surrounding postpartum depression often focus on mothers, a significant number of men are also struggling with this condition – now recognized as paternal postpartum depression. Experts note that as fathers take on more active parenting roles, they face an increased risk of depression between three and six months after a child's birth. Our guest explains the growing need for paternal mental health education and the vital resources available to help new dads navigate this challenging transition.Guests: Dr. Sheehan Fisher, associate professor of psychiatry and behavioral sciences, Northwestern University Feinberg School of MedicineHost: Greg JohnsonProducers: Kristen Farrah Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Joint pain is a common concern in pediatric practice. If a child is limping after sports or describes vague aches and pains, it often points to a minor injury or a self-limited condition. But in some cases, joint pain may signal something more serious. The challenge for pediatricians is knowing how to distinguish benign, mechanical causes from symptoms that warrant further evaluation. In this episode, we explain how to identify red herrings versus true red flags in pediatric joint pain. While awaiting a rheumatology referral, we'll talk about what primary care pediatricians can do in the meantime to support children and families facing the possibility of arthritis.    This episode was recorded on the exhibit floor at the 2025 American Academy of Pediatrics National Conference in Denver, Colorado. Angela Chun, MD, is the associate program director for the Division of Rheumatology at Lurie Children's Hospital of Chicago. She is also an assistant professor at the Northwestern University Feinberg School of Medicine.  Some highlights from this episode include: The most common reasons for joint pain in children Understanding juvenile idiopathic arthritis (JIA) and how it presents Common pitfalls that may lead to misdiagnosis What providers can do in their offices before a referral  For more information on Children's Colorado, visit: childrenscolorado.org. 

In this episode of the PRS Global Open Keynotes podcast, Dr. Arun Gosain and Dr Gabrielle Rodriguez discuss the efficacy of antifibrinolytic agents in decreasing blood loss in infant patients undergoing minimally invasive surgery for craniosynostosis.  This episode discusses the following PRS Global Open article: "Benefits of Antifibrinolytics in Minimally Invasive Surgical Repair of Single-suture Craniosynostosis"  by Gabrielle C. Rodriguez, Anitesh Bajaj, Parul Rai, Morgan A. Gamble, Emily George, Umer Qureshi, Taylor G. Hallman and Arun K. Gosain Read it for free on PRSGlobalOpen.com: https://journals.lww.com/prsgo/fulltext/2025/11000/benefits_of_antifibrinolytics_in_minimally.22.aspx Dr. Arun Gosain is Professor of Pediatric Plastic and Reconstructive Surgery at the Northwestern University Feinberg School of Medicine at the Ann and Robert H Lurie Children's Hospital of Chicago in Illinois. Dr. Gabrielle Rodriguez is a research fellow at The Gosain Plastic Surgery and Craniofacial Biology Laboratory. Your host, Dr. Damian Marucci, is a board-certified plastic surgeon and Associate Professor of Plastic Surgery at the University of Sydney in Australia. #PRSGlobalOpen; #KeynotesPodcast; #PlasticSurgery; Plastic and Reconstructive Surgery- Global Open The views expressed by hosts and guests are their own and do not necessarily reflect the official policies or positions of ASPS.

Co-hosts Ryan Piansky, a graduate student and patient advocate living with eosinophilic esophagitis (EoE) and eosinophilic asthma, and Holly Knotowicz, a speech-language pathologist living with EoE who serves on APFED's Health Sciences Advisory Council, interview Fei Li Kuang, MD, PhD, an allergist and immunologist, at Northwestern Medicine, about receiving two APFED HOPE on the Horizon Grants. Disclaimer: The information provided in this podcast is designed to support, not replace, the relationship between listeners and their healthcare providers. Opinions, information, and recommendations shared in this podcast are not a substitute for medical advice. Decisions related to medical care should be made with your healthcare provider. Opinions and views of guests and co-hosts are their own.   Key Takeaways: [:50] Co-host Ryan Piansky introduces this episode, brought to you thanks to the support of Education Partners GSK, Sanofi, Regeneron, and Takeda. Ryan introduces co-host Holly Knotowicz.   [1:14] Holly introduces today's topic, two APFED HOPE on the Horizon Pilot Grant Projects and today's guest, Fei Li Kuang, MD, PhD, an Assistant Professor in the Division of Allergy and Immunology at Northwestern University Feinberg School of Medicine in Chicago, Illinois.   [1:42] Dr. Kuang is a physician-scientist who takes care of patients with eosinophilic disorders and also performs laboratory research on these disorders in her lab, often using patient samples. Holly thanks Dr. Kuang for joining us.   [2:05] As a child, Dr. Kuang always wanted to be a scientist. She is so grateful to live out her childhood dream, and it's because of the amazing people who have supported her, most importantly, her parents.   [2:29] In graduate school, Dr. Kuang studied B cells. When she went on to do an allergy fellowship, she thought she would study B cells and care for patients with B cell problems. Instead, she fell in love with allergy and eosinophilic disorders.   [2:50] Dr. Kuang is here, in part, because of the different mentors she has had, and in large part, because of the patients she has met along the way.   [3:20] Dr. Kuang had the opportunity to work with Amy Klion at the NIH in a clinical trial to treat patients with a drug that gets rid of eosinophils. She says it was a dream come true after her training.   [4:02] She says she learned so much about eosinophils, their unusual biology, and the mystery behind what they are here for. She got hooked.   [4:15] Dr. Kuang thinks the patients you meet in a clinical trial in a special place like NIH occupy a space in your heart that makes you want to keep working on the subject area.   [4:34] Patients in a clinical trial have given up a bunch of their time to travel to Bethesda, Maryland. For the trial Dr. Kuang participated in as a Fellow, it was a good year of their time to come out and do it.   [4:47] Dr. Kuang felt there were so many interesting questions, from an intellectual point of view, but there was also a real need from patients with chronic conditions. It was a beautiful opportunity to marry scientists with physicians in training.   [5:36] Dr. Kuang shares some knowledge about eosinophils. They are white blood cells that are in all of us. They have little pink packages or granules that "jumped out" in the light microscope almost 200 years ago, when we first identified them.   [6:00] Dr. Kuang says that animals, dating back to reptiles, and different species of dolphins, all have eosinophils. A veterinary scientist, Dr. Nicole Stacy of the University of Florida, has taken photos of eosinophils from all these different species.   [6:21] They've been around for a long time. What are they good for? What we know is that they are associated with disease conditions, such as asthma and others, including leukemia. Those were the classic first studies of eosinophils.   [6:42] Now, we have a different mindset about eosinophils from work by the late James Lee at Mayo Clinic, Arizona.   [6:58] Dr. Kuang credits Dr. Lee with suggesting that eosinophils not just cause us problems but also help treat parasitic infections, maintain tissue homeostasis, help wound healing, and tissue repair. That's a new area we are beginning to appreciate.   [7:41] Dr. Kuang says we need to be open-minded that in some circumstances, eosinophils may be helpful or innocent. Now we have tools to start to understand some of that. We need to collect information from patients being treated with medicines.   [8:10] Ryan tells of being diagnosed as a kid. Doctors explained to him that eosinophils fight parasites, but in some people, they get confused and attack the esophagus. That's EoE. That was easy to understand, but he knew that the researchers knew more.   [8:53] Ryan is grateful to the patient population around eosinophilic esophagitis, and is proud of APFED's support of patients and caregivers with HOPE Grants. APFED has the HOPE on the Horizon Research Program, entirely funded by community donations.   [9:13] To date, APFED has directed more than $2 million toward eosinophilic disease research initiatives through various grant programs. As a patient advocacy organization, APFED works with fantastic researchers who submit innovative research ideas.   [9:32] These research ideas go through an extensive and competitive peer-review process, supported by researchers and clinicians in the APFED community.   [9:42] Today, we're going to discuss two different projects supported by HOPE Pilot Grants with Dr. Kuang.   [10:00] Dr. Kuang thinks there are two ways these grant programs are important to patients. One is advancing research by nurturing seedling investigators. Dr. Kuang got her first grant when she was a Fellow. It was an incredible opportunity.   [10:25] These grant programs also nurture seedling ideas that don't have enough evidence yet to garner the larger NIH grants, and so forth. There are other sources for grants: pharmaceutical companies. The grant programs are for seeds.   [10:49] Patients need to know that there are new things that are given some chance of being tested out. Research takes some time, and the FDA process of getting a drug approved is long.   [11:04] For the newly diagnosed patient, it can feel overwhelming. It feels like there's a loss of control. Sometimes, participating in something like APFED, being part of a community, gives back a sense of control that is lost when you're handed a diagnosis.   [11:45] For patients who have had it for a long time, when they participate in research and become engaged in organizations like APFED, they know they may not directly benefit today, they may benefit later, but they hope future patients will benefit.   [12:21] That gives them a sense of control and hope that things will be better for the next generation. We all want that, especially in medicine, in something that we don't have a very deep understanding of.   [12:58] Dr. Kuang received two HOPE Pilot Grants, one in 2018 and one in 2022. The first grant was awarded when she was a Fellow at the NIH.   [13:05] That first grant explored some effects of eosinophilic depletion of pathogenic lymphocytes in hypereosinophilic syndrome and overlaps with EGIDs. Ryan asks for a broad overview of that research.   [13:25] When Dr. Kuang was a Fellow at the NIH, they were doing a Phase 2 clinical trial, looking at "blowing up" eosinophils in patients who have a lot of them, hypereosinophilic syndrome patients.   [13:39] They included patients who had eosinophilic GI disease, often beyond the esophagus. They may have esophageal involvement, but sometimes their stomach is impacted, sometimes their large bowel is impacted, with related symptoms.   [13:57] What Dr. Kuang and the team noticed in the trial was that just within that little group of patients, there were people who did well, and people who did much better than before, but would have recurrent symptoms, and with no eosinophils in their GI tissues.    [14:16] The researchers wanted to know what was causing these problems for the patient. If you take eosinophils away, what other factors will impact the immune system of the patient, semi-long-term?   [14:32] Their focus was on these groups of patients who had different responses. They looked at the white blood cells that had been previously described as being the responsible, "bad" T cells that lead to eosinophils in the gut.   [14:49] They found that the patients who had recurrent flares of the disease had more of the bad T cells, and the patients who responded well and never complained again about symptoms did not.   [15:03] That allowed researchers to identify that there were subsets of patients with the disease that they were calling the same thing.   [15:18] Dr. Kuang says that work also led them to find that those cells were being reported in patients who had food allergies for which they needed an epinephrine auto-injector.   [15:27] The researchers were curious whether that was just a food allergy issue, or only applied if you had food allergies and eosinophilic GI disease. That HOPE project allowed them to do a pilot study to look at food allergy patients, too. They did, and published it.   [15:45] They published that in patients who have a food allergy and have these T cells, the insides of those cells make different messages for the immune system than the ones that the researchers had previously described.   [16:01] In looking for why there were differences in those responses, they accidentally found that there were differences inside these cells in a completely different disease, which also had these T cells.   [16:21] Dr. Kuang says that the finding was kind of a surprise. If they had found anything in the eosinophilic GI disease patients, that would have been good. They also looked at the epithelial cells and the structure of the GI lining.   [16:42] Even though there were no eosinophils in the GI lining in the patients who had been treated with a biologic that depleted eosinophils, their GI lining still looked like the GI lining of patients who had eosinophilic GI disease.   [16:55] Dr. Kuang asked what was creating those spots. Our gut lining sheds, so there should have been an opportunity for the GI lining to turn over and look new. Something was there, making signals to create these spots. They did a different publication on that.   [17:21] The data from the HOPE Pilot study allowed Dr. Kuang to apply for larger grants. It allowed her to propose to the company that made this drug, when they did the Phase 3 trial, to insert into that special study the study on eosinophilic GI disease.   [17:48] Do patients with eosinophilic GI disease do better or worse on this drug, and how do the T cells look in that trial? That HOPE Grant gave Dr. Kuang the data to ask the drug company to give her money to study it in an international cohort of patients.   [18:17] There were only 20 patients in that first NIH trial, who gave a year of their life, coming to NIH all the time. They continued to be in the study until the drug was approved for asthma.   [18:28] Dr. Kuang says the main reason the company did the Phase 3 trial, which is expensive, and the market share is not huge because it's a rare disease, is that two of the patients went to bat for this disease population.   [18:47] The two patients went and showed the business people what they looked like before, what the drug had done for them, and how their lives had changed. It wasn't the doctors or the great paper from the trial, but the patients who convinced the company.   [19:01] Dr. Kuang says she was so floored by that and moved by what they did for the community. She is grateful.   [19:24] Since the Phase 3 trial, Dr. Kuang and the other researchers realized they had not fully studied the eosinophils. They had studied them in part. They found differences in response. This inspired the second APFED HOPE Pilot Grant.   [21:19] In 2022, Dr. Kuang received a two-year APFED HOPE Pilot Grant to examine how blood eosinophils in Eosinophilic Gastrointestinal Diseases differ from those of other eosinophilic diseases and how T cells in EGIDs differ from those in food allergies.   [21:49] Dr. Kuang says normally, the biggest place of residence for eosinophils is the GI tract. That's where they are normally seen in people who do not have eosinophilic disorders.   [21:59] People who have eosinophilic disorders that attack other parts of the body, asthma, and rarely, the heart. Dr. Kuang was curious to know why one person and not the other?   [22:15] Patients who have eosinophilic GI disease often ask, How do you know this high level in the blood is not going to attack my heart or my lungs in the future? Dr. Kuang does not know.   [22:29] Dr. Kuang says, looking at the cohort at the NIH, that for many patients who have both GI organ involvement and some other space, when they first went to see a provider, their first complaint was a GI condition.   [22:54] If the doctor had only diagnosed a GI condition, nothing else, that would have been wrong. Those patients may not have been monitored as well. A third of the patients originally presented like that.   [23:11] What that meant was that we should be paying attention to patients who have GI disease who have lots of eosinophils in their blood. Moving forward, if there are new complaints, we need to investigate. We can't forget they have that.   [23:27] Dr. Kuang asks, Wouldn't it be great if we had a better tool than needing to wait? Wouldn't it be great if we had a biomarker that said the eosinophils have switched their target location and are going somewhere else?   [23:41] One way to do that is to take different groups of eosinophils and look for differences between those that never target the GI tract and those that do. In patients who have EoE, the eosinophils only target or cause problems in the esophagus.   [23:58] Are their eosinophils any different than those of a healthy person, with none of these conditions? That was the goal of that study.   [24:10] T cells are another type of white blood cell. They contain a memory of foreign things they have encountered, which allows them to glom onto flu, COVID, peanuts, pollen, that kind of thing. They remember.   [24:32] Dr. Kuang says they learned that T cells, at least in the mouse model, are required in the development of eosinophilic esophagitis. The mice in the old study, where mice were forced to develop EoE, did not get EoE if you removed their T cells.   [24:50] In the first APFED HOPE grant study, Dr. Kuang found T cells in the blood and tissue of both EGIDs and food allergy patients, but the insides of the T cells were different. The food allergy patients were children recruited by a pediatric allergist.   [25:19] In the second APFED HOPE grant study, at Northwestern, Dr. Kuang recruited her adult food allergy patients. That was a way to validate what they found in the first study and move further to better characterize those T cells in the two different diseases.   [25:47] Dr. Kuang says we're at a point where we've recruited a lot of people. She says it's amazing what people are willing to do. It's very humbling.   [26:06] Dr. Kuang's team in the lab is really great, too. To accommodate patients, they would see them after work, if that's what they had to do to isolate eosinophils. So they did that, and now they are in the process of analyzing that data. It's really exciting.   [26:28] What's exciting is that they are seeing results that show that eosinophilic GI disease patients have circulating eosinophils that are different from the eosinophils of people who don't have GI involvement, and from people who have EoE.   [26:46] The EoE patients have eosinophils different from those of healthy donors. Dr. Kuang says there's a lot of promise for perhaps unique signatures that could help define these conditions; maybe someday without biopsying, but that's a long time away.   [27:16] Dr. Kuang says they will focus on some candidate targets and try to recreate some of that in a dish with eosinophils from healthy people.   [27:26] What are the signals that lead eosinophils to do this, and can we translate that back to available drugs that target certain cytokines or other pathways, and maybe give some insight to develop drugs that target other pathways for these diseases?   [28:17] Ryan thinks it's exciting that this research is narrowing in on not only the different symptoms, but also how the eosinophils are acting differently in these populations.    [28:44] Dr. Kuang is super excited about this research. You could imagine that all eosinophils are the same, but you don't know until you look. When they looked, using the newest technology, they found there were differences.   [29:33] Dr. Kuang says it is thought that T cells respond to triggers. We don't think eosinophils have a memory for antigens. T cells do. That's one of their definitions. When T cells react to a trigger, they give out messages through cytokines or by delivery.   [30:20] Those are the messages that recruit eosinophils and other cells to come and stir up some trouble.   [30:28] In the mouse model, where you don't have the T cells, and you don't get eosinophilic esophagitis in the particular way they made it happen in a mouse, that middle messenger is gone, so the eosinophils don't know where to go.   [30:44] With drugs that take out eosinophils, you think that you've gotten rid of the cell that creates all the problems. It shouldn't matter what the message says because there's no cell there to cause the damage.   [30:58] What Dr. Kuang learned is that, at least in certain eosinophilic GI diseases, that's not true. You erase the eosinophils from the picture, but that message is still coming.   [31:10] Who's carrying out the orders? Or is that message maintaining the wall of epithelial cells in a certain way that we didn't appreciate because the eosinophils were also there?   [31:24] It's important to study both, because one is the messenger and the other is one of the actors. Whether all of the actions taken by eosinophils are bad, or maybe some of them were meant to be good, we have yet to learn.   [31:40] At the moment, we're using it as a marker for disease activity, and that may change in the future, as we learn more about the roles of these cells in the process.   [31:50] We have drugs now that target eosinophils and drugs that target T cells. Dr. Kuang thinks it's important to study both and to study the impact of these drugs on these cells.   [32:02] You could theoretically use these drugs to understand whether, if someone responds to it, what happens to these cells, and if someone doesn't respond to it, what happens to these cells, and how this disease manifests in this flavor of patients.   [32:54] Dr. Kuang says, Often in science, we take a model. We think this works this way. Then, if this works this way, we expect that if we remove this, these things should happen. We did that with the first clinical trial, with NIH patients.   [33:10] It didn't quite happen the way we thought, so we had to go looking for explanations. These were unusual setbacks. Sometimes you have unusual findings, like the food allergy part.   [33:24] When Dr. Kuang went to Northwestern, she saw different cohorts of patients than she saw at NIH. She saw people who were seen every day, which is a different spectrum than those who are selected to be enrolled in a study protocol at the NIH.   [33:42] That broadened her viewpoint. It's maybe not all food-triggered. They were seeing adults who'd never had food allergies or asthma their whole life, and they had eosinophilic esophagitis suddenly as a 50-year-old. There's a significant group of them.   [34:10] What Dr. Kuang learned and tries to be open-minded about is that where you train, what sorts of patients you see, really shape your viewpoint and thinking about the disease process and the management process.   [34:24] Dr. Kuang says she was so lucky to have experienced that at a quaternary care referral center like the NIH and at an academic center like Northwestern, where there are fantastic gastroenterologists who see so many of these patients.   [34:56] Dr. Kuang and an Allergy Fellow knew they were going to get a wonderful data set from the NIH patients they had recruited, so they thought they had better look deeply at what had been learned before with older technology, with mice and people.   [35:13] They decided to gather previous research, and that ultimately got published as an article. From that research, they learned that people did things in many different ways because there was no standard. They didn't know what the standard should be.   [35:28] Different things you do to try to get eosinophils out of tissue impact how they look, in terms of transcript, gene expression, and what messages they make to define themselves as an eosinophil.   [35:43] They also learned that because eosinophils are hard to work with, they die easily, and you can't freeze them and work on them the next day; you can introduce issues in there that have to be accounted for.   [35:59] They learned that as an eosinophil research community, they ought to come up with some standards so that they can compare future studies with each other. Dr. Kuang says it was impossible to compare the old studies that used different premises.   [36:50] Dr. Kuang says we need to be proactive in creating the datasets in a standard way so that we can compare and have a more fruitful and diverse community of data. It's hard to use the old data.   [37:57] Dr. Kuang says they get fresh blood from patients, and because eosinophils are finicky, they need to be analyzed within four hours, or preserved in a way to save whatever fragile molecules are to be studied.   [38:19] If you let it sit, it starts dying, so you won't have as many of them, and they start changing because they're not in the body. Dr. Kuang experimented with putting a tube of blood on the bench and checking it with the same test every two hours. It changes.   [38:38] Four hours is a standard to prevent the eosinophils from dying. Patients need treatment. If a patient is hospitalized and needs treatment, Dr. Kuang's team needs to be there to get a sample before treatment is started.   [39:03] The treatment impacts it, changing the situation. Much of the treatment, initially, is steroids. When you give lots of steroids, the eosinophils go away. It's no good to draw their blood then.   [39:27] Dr. Kuang also gets a urine sample. The granules of the eosinophils can get into the urine. As they study people with active disease, they want to capture granule proteins in the urine as a less invasive way to monitor activity in different disease states.   [40:04] The patient just needs to give Dr. Kuang either arm and a urine sample.   [41:04] Dr. Kuang explains, you can count your eosinophils after four hours, but to study them, they have different flags of different colors and shapes. Those colors and shapes may mean that it's an activated eosinophil, or they may have other meanings.   [41:41] Dr. Kuang focused on markers that look at whether it's going to spill its granules and some traditional markers of activation.     [41:50] Everyone chooses a different marker of activation. So they decided to look at as many as they could. One marker is not sufficient. They seem to be different in different conditions. The markers are on the surface; you need to analyze them right away.   [42:20] Then, Dr. Kuang breaks open the eosinophils and grabs the messenger RNA. They preserve it to do sequencing to read out the orders to see what this eosinophil is telling itself to make. RNA chops up messages.   [43:00] When you open an eosinophil, a protein you find is RNA, which chops up messages, destroying parts of the cell. You want to save the message. There's a brief time to analyze the eosinophil. Dr. Kuang works to preserve and read the message.   [44:04] Dr. Kuang hopes someday to run a tube of blood, look at the flags on the eosinophils, and say, "I think your eosinophilic GI disease is active," or "You have a kind of eosinophilic GI disease we need to monitor more frequently for organ damage."   [44:38] If another patient doesn't have those flags, Dr. Kuang could say, "I think the chances that you're going to have involvement elsewhere are low." That can give reassurance to folks who are worried.   [45:15] Dr. Kuang hopes that someday we can understand better why some people have food allergies vs. eosinophilic GI disease. They both have T cells, but the T cells have different packages inside with messages to deliver.   [45:34] Every day, Dr. Kuang has to tell patients she doesn't have that answer. Someday, she hopes she can tell a patient she does have that answer.   [46:35] Dr. Kuang tells about an NIH grant she's excited about and the patients she recruits after therapy, or elimination diets, to examine eosinophils and T cells, to see the impacts their treatments or diets have had on eosinophilic GI disease.   [47:18] Dr. Kuang believes there will be predictors of who will respond to an elimination diet and who will respond to steroid therapy. She hopes one day to have that, rather than going through rounds of six to eight weeks followed by a scope.   [47:34] If you have an elimination diet for six to eight weeks, every time you add back a food, you have to do a scope. Dr. Kuang says it would be great if you could be more precise ahead of time for therapy.   [47:48] Dr. Kuang says these wonderful drugs selectively take out parts of the pathway in the immune system. They provide real-life opportunities to ask, why is this important in human biology and the human immune system?   [48:15] Dr. Kuang finds the knowledge itself fascinating and useful. She hopes it informs how we choose future drugs or therapeutic avenues to get the best we can out of what we've learned, so we have more targeted ways of treating specific diseases.   [48:48] Ryan is grateful for all the research happening for the eosinophilic disease community and all the patients participating in the research. He asks Dr. Kuang how a patient can participate in research.   [49:12] There are lots of ways to be involved in research. Dr. Kuang says her patients come away from participating in research feeling good about having done it.   [49:22] Answer a survey, if that's what you have bandwidth for. Where therapies are changing, being a part of a community is good for the community, for the future, but it's good for you, too. It's healing in ways that are not steroids or biologics.   [49:58] Being part of a community is healing in ways we all need when we feel alone and bewildered. You're not alone.   [50:12] There are many ways to participate: APFED, CEGIR, individual institutions, and clinical trials. They all have different amounts of involvement. It's worthwhile to participate, not only for future patients but for yourself. They're fantastic!   [50:56] Dr. Kuang talks about the privilege as a physician of working with APFED and other organizations to do this work.   [51:09] Holly thanks Dr. Kuang for sharing all of this research and exciting information.   [51:25] Dr. Kuang is excited about what her group is doing and is hopeful. Besides showing up for this disease, we have to show up for research, in general, in this country. It's a dark time for NIH research funding.   [51:55] Dr. Kuang asks the young listeners who are thinking of choosing a field to see the potential and get into it, study this, and believe that there's going to be a future with a more nurturing research environment.   [52:36] Dr. Kuang would hate to lose generations of scientists. She says that once she was a little girl who was trying to be a scientist. Her parents had no connections with scientists or doctors, but she was able to get into research, and she thinks you can, too.   [53:48] As a graduate student, Ryan has always been interested in trying to improve things, and he sees hope on the horizon. He's very grateful to the APFED community for supporting these research HOPE Pilot Grants.   [54:17] Ryan is very grateful to Dr. Kuang for joining us today.   [54:22] For our listeners who want to learn more about eosinophilic disorders, we encourage you to visit apfed.org and check out the links in the show notes.   [54:28] If you're looking to find a specialist who treats eosinophilic disorders, we encourage you to use APFED's Specialist Finder at apfed.org/specialist.   [54:37] If you'd like to connect with others impacted by eosinophilic diseases, please join APFED's online community on the Inspire Network at apfed.org/connections.   [54:57] Dr. Kuang thanks Ryan and Holly and says she enjoyed the conversation. Holly also thanks APFED's Education Partners GSK, Sanofi, Regeneron, and Takeda for supporting this episode.   Mentioned in This Episode: Fei Li Kuang, MD, PhD, Allergist and Immunologist, Northwestern Medicine   Grants and publications discussed: Apfed.org/blog/apfed-announces-2018-hope-apfed-hope-pilot-grant-recipient/ Apfed.org/blog/fei-li-kuang-hope-pilot-grant-award/  Pubmed.ncbi.nlm.nih.gov/39213186/ Pubmed.ncbi.nlm.nih.gov/37487654/   APFED on YouTube, Twitter, Facebook, Pinterest, Instagram Real Talk: Eosinophilic Diseases Podcast apfed.org/specialist apfed.org/connections apfed.org/research/clinical-trials   Education Partners: This episode of APFED's podcast is brought to you thanks to the support of GSK, Sanofi, Regeneron, and Takeda.   Tweetables:   "I think the patients that you meet in a clinical trial, especially in a special place like NIH, occupy a space in your heart — I don't mean to be all too emotional about this — that makes you want to keep working on the subject area." — Fei Li Kuang, MD, PhD   "When I was a Fellow at the NIH, we were doing a Phase 2 clinical trial, looking at, for want of a better word, "blowing up" eosinophils in patients who have a lot of them, hypereosinophilic syndrome patients." — Fei Li Kuang, MD, PhD   "We're at a point where we've recruited a lot of people. I've had patients drive from the northern part of Illinois … come down and give me blood. It's amazing what people want to do and are willing to do. It's very humbling, actually." — Fei Li Kuang, MD, PhD   "You erase the eosinophils from the picture, but that message is still coming. Who's carrying out the orders? Or is that message maintaining the wall of epithelial cells in a certain way that we didn't appreciate because the eosinophils were also there?" — Fei Li Kuang, MD, PhD   "We need to be proactive in creating the datasets in a standard way so that we can compare and have a more fruitful and diverse community of data." — Fei Li Kuang, MD, PhD   "I think it's worthwhile to participate [in a clinical trial], not only for the future people but for yourself." — Fei Li Kuang, MD, PhD   Guest Bio: Fei Li Kuang, MD, PhD, is currently an Assistant Professor in the Division of Allergy and Immunology at Northwestern University Feinberg School of Medicine in Chicago, IL. She is a graduate of the Albert Einstein College of Medicine Medical Scientist Training Program with both a PhD in Cell Biology/Immunology and an MD.  She completed her Internal Medicine Residency at Columbia University, New York Presbyterian Hospital in New York City, she did her Fellowship in Allergy and Immunology at the National Institute of Allergy and Infectious Disease (NIAID) in Bethesda, Maryland. She is a physician-scientist who takes care of patients with eosinophilic disorders and also performs laboratory research on these disorders in her lab, often using patient samples.

In today's episode, we had the pleasure of speaking with Jacob Sands, MD, and Shailee Shah, MD, about considerations for diagnosing and managing Lambert-Eaton myasthenic syndrome (LEMS), particularly in the context of small cell lung cancer (SCLC). Dr Sands is associate chief of the Lowe Center for Thoracic Oncology and the Oncology Medical Director of the International Patient Center at Dana-Farber Cancer Institute, as well as an assistant professor at Harvard Medical School in Boston, Massachusetts. Dr Shah is a clinical assistant professor of neurology (MS/neuroimmunology) at the Northwestern University Feinberg School of Medicine in Chicago, Illinois.  In our exclusive interview, Drs Sands and Shah discussed LEMS symptom identification, the importance of paraneoplastic panels for assessing neurologic dysfunction in patients with SCLC, the need for specific autoantibody testing, and what guidelines currently note as best practices for the diagnosis of this disease. 

In this episode of Lab Rats to Unicorns, John Flavin sits down with Dr. Joseph Leventhal, Professor of Surgery and Director of Living Donor Kidney Transplantation at Northwestern University Feinberg School of Medicine. A pioneer in the field of organ transplantation, Dr. Leventhal's research is redefining what's possible in immune tolerance—an area often described as the “holy grail” of transplantation, where a patient's body can accept a donated organ without lifelong immunosuppressive drugs.Dr. Leventhal shares his journey from growing up in New York City to becoming one of the foremost leaders in transplant surgery and cell therapy innovation. He discusses how his team's groundbreaking clinical work has shown that tolerance can be achieved through cellular therapies, potentially freeing patients from the burdens of chronic immunosuppression.From the early days of cyclosporine to founding TRACT Therapeutics and developing first-in-human T-regulatory cell therapies, Joe reflects on the scientific curiosity, resilience, and collaboration that drive progress in a complex field. He also explores the evolving ecosystem for biotech innovation in Chicago, the challenges of translating academic research into clinical therapies, and the optimism surrounding the next generation of precision cell therapies.

Mapping the Landscape of Technical Standards: A Nationwide Review of Medical Schools Interviewees: Carol Haywood, PhD, OTR/L — Assistant Professor, Medical Social Sciences, Northwestern University Feinberg School of Medicine Chris Moreland, MD, MPH — Professor of Internal Medicine; Division Chief for Hospital Medicine; Interim Associate Chair for Faculty Affairs and Development, Dell Medical School (Comments made in ASL and voiced through interpreters) Interviewer: Lisa Meeks, PhD, MA — Guest Editor, Academic Medicine Supplement on Disability Inclusion in Undergraduate Medical Education Description: In this episode of Stories Behind the Science, we sit down with Dr. Carol Haywood and Dr. Chris Moreland to explore a deceptively powerful document: the medical school technical standards. These quietly influential statements—often tucked deep in an admissions webpage—shape who feels welcome to apply, who gains access, and how institutions imagine the future of their profession. Haywood and Moreland, co-authors of a national analysis featured in the Academic Medicine supplement on Disability Inclusion in Undergraduate Medical Education, unpack what happens when ambiguous language, outdated assumptions, and vague expectations collide with real people making real decisions about their careers. Together, they dig into the nuances of functional vs. organic standards, the importance of clarity for applicants who lack insider knowledge, and the ripple effects of inequitable policies across a learner's entire training experience. What emerges is both sobering and hopeful: a field undergoing change, a growing recognition that words matter, and a roadmap for institutions ready to bring their values into alignment with their practices. The discussion reviews: How technical standards became a gatekeeper—and why revising a single sentence can shift an entire culture. Why students with disabilities read these documents differently—and why that matters for equity. How ambiguity in admissions can deter talented future physicians long before they step foot in a classroom. What schools can do now to create standards that prioritize competence, flexibility, and inclusion. Dr. Haywood brings a researcher's lens and an occupational therapist's creativity to the conversation, illuminating how functional expectations—not assumptions about bodies—should guide medical training. Dr. Moreland shares deeply personal reflections on navigating technical standards as a deaf physician, offering rare insight into how these documents land on applicants with lived experience. This episode invites the audience to imagine a medical education landscape where technical standards do what they should do—define competence, set expectations, and open doors—rather than unintentionally closing them. Bios:  Carol Haywood, PhD, OTR/L, is Assistant Professor of Medical Social Sciences in the Determinants of Health Division and core faculty in the Center for Health Services and Outcomes Research at Northwestern University Feinberg School of Medicine in Chicago, IL. Building from her work as an occupational therapist in acute rehabilitation, she completed a PhD in occupational science at the University of Southern California and a postdoctoral fellowship in health services and outcomes research at Northwestern University. Using qualitative, mixed methods, and community-engaged research approaches, she studies disability in a variety of contexts, as well as health care access, coordination, and quality. She is driven by a vision of health care that facilitates equity for people with disabilities. Chris Moreland, MD MPH, is a professor of medicine, interim associate department chair for faculty affairs, and division chief for hospital medicine at Dell Medical School at UT Austin. He practices clinically as a hospitalist. As a career-long clinician educator, his teaching has been recognized regionally and nationally. His collaborative advocacy and research efforts describe the experiences of our healthcare workforce and learners with disabilities, as well as strategies to foster pathways to thriving clinicians. He has served as president and longtime board member for the Association of Medical Professionals with Hearing Losses; he holds current roles on the Docs with Disabilities Initiative advisory board, the AAMC Group on Diversity and Inclusion steering committee, and as a consultant with the National Deaf Center. Transcript: https://docs.google.com/document/d/18hUPguWf_jWeDC1fmOgSKSXPv4xGnkQIPUi3zhfH540/edit?usp=sharing Resources: Singer, Tracey; Madanguit, Lance MD; Fok, King T. MD, MSc; Stauffer, Catherine E. MD; Meeks, Lisa M. PhD, MA; Moreland, Christopher J. MD, MPH; Huang, Lynn MS; Case, Benjamin MPH; Lagu, Tara MD, MPH; Kannam, Allison MD; Haywood, Carol PhD, OTR/L. Mapping the Landscape of Technical Standards: A Nationwide Review of Medical Schools. Academic Medicine 100(10S):p S144-S151, October 2025. | DOI: 10.1097/ACM.0000000000006135   McKee, M.M., Gay, S., Ailey, S., Meeks, L.M. (2020). Technical Standards. In: Meeks, L., Neal-Boylan, L. (eds) Disability as Diversity. Springer, Cham. https://doi.org/10.1007/978-3-030-46187-4_9 Equal Access for Students with Disabilities: The Guide for Health Science and Professional Education (2nd Ed). Meeks LM, Jain NR, & Laird EP. Springer Publishing, 2020. Key Words: Disability inclusion · Technical standards · Medical education · Admissions · Accessibility · Equity · Policy reform

In this podcast, Series 4, Chapter 5, Dr. Barsuk interviews Dr. Diane Wayne, professor of medicine in the Departments of Medicine and Medical Education and former Internal Medicine Program Director and Vice Dean of Education at Northwestern University Feinberg School of Medicine.  Dr. Wayne  is currently the Chief Medical Officer and Senior Vice President at Northwestern Memorial Hospital.  Drs. Barsuk and Wayne discuss how simulation-based mastery learning can be used to train clinicians across the entire spectrum of students, residents, fellows, and practicing clinicians.

BUFFALO, NY – October 20, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on October 16, 2025, titled “Widespread folate receptor expression in pediatric and adolescent solid tumors – opportunity for intraoperative visualization with the novel fluorescent agent pafolacianine.” In this study, led by first author Ashley C. Dodd from Ann & Robert H. Lurie Children's Hospital and corresponding author Timothy B. Lautz from the same institution and Northwestern University Feinberg School of Medicine, researchers discovered that folate receptor beta (FRβ) is widely expressed in various pediatric and adolescent solid tumors. This finding highlights FRβ as a promising target for improving the accuracy of tumor surgery using a fluorescent imaging agent known as pafolacianine. Pediatric cancers are often challenging to remove completely during surgery, particularly when tumors spread or form small metastases. Fluorescence-guided surgery is a method that helps surgeons better identify tumors during operations using special imaging dyes. However, commonly used dyes such as indocyanine green are not tumor-specific and rely on general features of blood vessel permeability, limiting their precision. In this study, researchers investigated the potential of pafolacianine, a next-generation dye that targets folate receptors, for pediatric use. Folate receptors are proteins commonly found on the surface of cancer cells. Pafolacianine is already FDA-approved for adults with ovarian and lung cancers due to its ability to bind these receptors and highlight tumors during surgery. The research team analyzed tissue samples from 13 young patients diagnosed with various cancers, including Wilms tumor, osteosarcoma, synovial sarcoma, rhabdomyosarcoma, Ewing sarcoma, and neuroblastoma. The results showed that FRα was predominantly absent, whereas FRβ was present in 100% of the tumor samples. Notably, FRβ appeared both on the tumor cells and in the surrounding tumor microenvironment but showed little to no expression in normal tissue, making it an excellent candidate for targeted imaging. “In this study, we performed immunohistochemistry staining on slides obtained from a range of pediatric patients with solid tumors.” This consistent expression of FRβ in pediatric tumors is a significant and novel finding. Earlier studies primarily linked FRβ to immune cells called tumor-associated macrophages. This study reveals that FRβ is also expressed directly on tumor tissue, which could help surgeons better distinguish cancer from healthy tissue during procedures. Based on these results, the team has launched a clinical trial to evaluate pafolacianine in children undergoing surgery for metastatic lung tumors. If successful, this method could make pediatric cancer surgery safer and more effective. Overall, this study suggests that targeting FRβ with pafolacianine could serve as a tumor-agnostic imaging strategy, applicable across a wide range of pediatric solid tumors. This represents a potential advancement in real-time surgical imaging and a step forward in pediatric cancer care. DOI - https://doi.org/10.18632/oncotarget.28772 Correspondence to - Timothy B. Lautz - TLautz@luriechildrens.org Abstract video - https://www.youtube.com/watch?v=0its0QkOcwM Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

In this special Complex Care Journal Club podcast episode, co-hosts Kilby Mann, Kristie Malik, and Kathleen Huth interview presenters of posters relevant to the care of children with medical complexity at the American Academy of Pediatrics 2025 National Conference & Exhibition. Speakers describe their study findings and implications for practice. Dr. Rishi Agrawal discusses the role of the Council on Children with Disabilities in translating research into improved clinical care and advocacy for children with medical complexity. SPEAKERS Rishi Agrawal, MD, MPH Professor of Pediatrics, Northwestern University Feinberg School of Medicine, Attending Physician, Ann & Robert H. Lurie Children's Hospital of Chicago Elizabeth Avery ‌Hill, DO Assistant Professor, University of Utah‌ Michelle Melicosta, MD, MPH, MSC, Associate Chief Medical Officer, Kennedy Krieger Institute, Assistant Professor, Johns Hopkins University School of Medicine Patricia Notario, MD, Medical Director of the Pediatric Complex Care Program, Billings Clinic Prasiddha Parthasarathy, MD, Resident, University of Toronto HOSTS Kristina Malik, MD Assistant Professor of Pediatrics, University of Colorado School of Medicine Medical Director, KidStreet Pediatrician, Special Care Clinic, Children's Hospital Colorado Kilby Mann, MD Assistant Professor Pediatric Rehabilitation Medicine Children's Hospital Colorado Kathleen Huth, MD, MMSc Pediatrician, Complex Care Service, Division of General Pediatrics Boston Children's Hospital Assistant Professor of Pediatrics Harvard Medical School DATE Initial publication date: October 14, 2025. RESOURCES REFERENCED ‌Project ECHO/ECHO Model: https://projectecho.unm.edu/model/ ‌Council on Children with Disabilities (COCWD): https://www.aap.org/en/community/aap-councils/council-on-children-with-disabilities/ ‌AAP Experience National Conference Denver 2025 - Conference Schedule: https://aapexperience.org/schedule/ TRANSCRIPT https://cdn.bfldr.com/D6LGWP8S/at/m48sjfwmqfnrfwnxg8p7p88/CCJCP_2025_AAP_conference_10-13-25.pdf Clinicians across healthcare professions, advocates, researchers, and patients/families are all encouraged to engage and provide feedback! You can recommend an article for discussion using this form: https://forms.gle/Bdxb86Sw5qq1uFhW6. Please visit: http://www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open-access thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu CITATION Mann K, Malik K, Agrawal R, Hill EA, Melicosta M, Notario P, Parthasarathy P, Huth K. Practice-Changing Research in Complex Care at the American Academy of Pediatrics Conference 2025. 10/2025. OPENPediatrics. Online Podcast. https://soundcloud.com/openpediatrics/practice-changing-research-in-complex-care-at-the-american-academy-of-pediatrics-conference-2025.

In this episode, Sterling Elliott, PharmD, Clinical Pharmacist Lead at Northwestern Medicine and Assistant Professor at Northwestern University Feinberg School of Medicine, joins Scott Becker to discuss advancing non-opioid pain management, the transformation of community pharmacy, and the power of communication in improving patient care and recovery outcomes.

In this episode, we reconnect with Dr. Peter Lio, MD. Dr. Lio completed his medical and dermatology training at Harvard Medical School and currently serves as a clinical assistant professor of dermatology and pediatrics at Northwestern University Feinberg School of Medicine. He also runs a private practice in the Chicago area, where he leads the Chicago Integrative Eczema Center.In this second part of our two-part series, Dr. Lio reflects on his experiences in academic medicine versus private practice, offering students key considerations when deciding between the two. He also discusses his collaborations with the medical industry and closes with a lighter topic, pizza. Tune in to hear his perspective on living the full life of dermatology.If you enjoyed this episode, please share it with other students interested in dermatology!Learn MoreEducational links: - ⁠Chicago Integrative Eczema Center⁠- ⁠Journal of Integrative Dermatology⁠- ⁠Integrative Dermatology Symposium⁠- ⁠Medical Acupuncture Course⁠- ⁠Integrative Dermatology Certificate Program⁠Website:- ⁠The Pizza Prescription⁠- ⁠Dr. Lio's Practice⁠---DIGA Instagram: @⁠derminterest⁠Today's Host, George: @⁠georgepapadeas⁠---For questions, comments, or future episode suggestions, please reach out to us via email at ⁠⁠⁠⁠⁠⁠⁠⁠derminterestpod@gmail.com⁠⁠⁠⁠⁠⁠⁠⁠---Music: "District Four" Kevin MacLeod (⁠⁠⁠⁠⁠⁠⁠⁠incompetech.com⁠⁠⁠⁠⁠⁠⁠⁠) Licensed under Creative Commons:By Attribution 4.0 License:⁠⁠⁠⁠⁠⁠⁠⁠ http://creativecommons.org/licenses/by/4.0/

In this episode, we sit down with Dr. Peter Lio, MD. Dr. Lio trained in medicine and dermatology at Harvard Medical School, later serving on faculty, and now practices in the Chicago area as founder of the Chicago Integrative Eczema Center. He is also a clinical assistant professor of dermatology and pediatrics at Northwestern University Feinberg School of Medicine. Beyond his clinical roles, he has cultivated unique interests, including acupuncture training, integrative medicine, and his love for pizza.In this first part of our two-part series, Dr. Lio shares his journey to dermatology and his focus on eczema, along with how he has helped to grow and shape the integrative dermatology field. Listen in to hear what it means to truly live the full life of dermatology.If you enjoyed this episode, please share it with other students interested in dermatology!Learn MoreEducational links: - Chicago Integrative Eczema Center- Journal of Integrative Dermatology- Integrative Dermatology Symposium- Medical Acupuncture Course- Integrative Dermatology Certificate ProgramWebsite:- The Pizza Prescription- Dr. Lio's Practice---DIGA Instagram: @derminterestToday's Host, George: @georgepapadeas---For questions, comments, or future episode suggestions, please reach out to us via email at ⁠⁠⁠⁠⁠⁠⁠derminterestpod@gmail.com⁠⁠⁠⁠⁠⁠⁠---Music: "District Four" Kevin MacLeod (⁠⁠⁠⁠⁠⁠⁠incompetech.com⁠⁠⁠⁠⁠⁠⁠) Licensed under Creative Commons:By Attribution 4.0 License:⁠⁠⁠⁠⁠⁠⁠ http://creativecommons.org/licenses/by/4.0/

Dr. Larry Gray, associate professor of pediatrics in the division of developmental and behavioral pediatrics at Northwestern University Feinberg School of Medicine and a physician at Ann & Robert H. Lurie Children's Hospital of Chicago, joins John Williams to talk about the Trump administration linking autism to Tylenol use during pregnancy. Dr. Gray talks about […]

Dr. Larry Gray, associate professor of pediatrics in the division of developmental and behavioral pediatrics at Northwestern University Feinberg School of Medicine and a physician at Ann & Robert H. Lurie Children's Hospital of Chicago, joins John Williams to talk about the Trump administration linking autism to Tylenol use during pregnancy. Dr. Gray talks about […]

Dr. Larry Gray, associate professor of pediatrics in the division of developmental and behavioral pediatrics at Northwestern University Feinberg School of Medicine and a physician at Ann & Robert H. Lurie Children's Hospital of Chicago, joins John Williams to talk about the Trump administration linking autism to Tylenol use during pregnancy. Dr. Gray talks about […]

This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright break down five eye-opening research studies from 2025 that challenge everything you thought you knew about obesity, dieting, and metabolism. The hosts explore surprising new evidence on fitness trackers, the metabolic power of joy (and dessert!), the risks of intermittent fasting, how yo-yo dieting can damage kidney health, and the permanent impact of dieting on your brain-gut connection.Dr. Cooper shares clinical insights and explains why simple fixes—strict diets, calorie counting, and food restriction—can actually backfire, causing more harm than good. From the science of hormone signaling to the pitfalls of diet culture, the conversation reveals powerful new reasons to embrace flexibility, balance, and self-kindness on the journey to metabolic health.Key Takeaways:Fitness trackers can dramatically underestimate calorie burn—errors can reach 93%, especially for people with higher body weight. Companies rarely test enough real-world diversity and may fudge numbers for marketing.Including dessert and “forbidden foods” in your diet leads to better metabolic outcomes, greater mental stability, and less risk of binge eating or weight regain. Joyful eating helps regulate critical hormones like leptin and ghrelin.Intermittent fasting is linked to hair loss. Energy deficits force the body to use fatty acids as fuel, which can damage hair follicle stem cells. Long-term fasting negatively disrupts glucose/insulin balance and destabilizes metabolism.Yo-yo dieting (weight cycling) now shows a direct connection with kidney damage—even in those at normal weight. Rapid weight shifts restrict kidney blood flow, raise cortisol, and cause irreversible damage.Dieting creates lasting changes in the microbiome and brain-gut signaling that promote weight regain and appetite dysregulation. Even a single round of weight cycling can create stubborn metabolic obstacles.Personal Stories & Practical Advice:Andrea shares why dessert is a staple of her happiness—and how mental restriction backfires. Dr. Cooper gives real-world examples from patients: eating favorite foods can unlock better weight results, while “diet damage” often lingers until medical treatment repairs it. Resources from the episode:Fat Science is a podcast on a mission to explain where our fat really comes from and why it won't go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn't a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.Check out our new website where you can ask a mailbag question. If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.com.Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.REFERENCES FOR THIS EPISODEAlshurafa, N., et al. (2025). “More accurate fitness tracking for people with obesity.” *Scientific Reports*, Northwestern University Feinberg School of Medicine.Alfouzan, N.W., & Nakamura, M.T. (2025). “Reduced food cravings correlated with a 24-month period of weight loss and weight maintenance.” *Physiology & Behavior*, Vol. 291.Chen, H., Liu, C., Cui, S., et al. (2025). “Intermittent fasting triggers interorgan communication to suppress hair follicle regeneration.” *Cell*, Vol. 188.The Endocrine Society (2025). “Yo-yo dieting may significantly increase kidney disease risk in people with type 1 diabetes.” *Journal of Clinical Endocrinology & Metabolism*, February 2025.Fouesnard, M., et al. (2025). “Weight cycling deregulates eating behavior via the induction of durable gut dysbiosis.” *Advanced Science*, 2025

In this episode,  Dr. Derek Wheeler, COO of Lurie Children's Hospital and Professor of Pediatrics at Northwestern University Feinberg School of Medicine, shares insights on driving improvements in patient safety, staff well-being, and family experience while navigating financial headwinds and strengthening the hospital's long-standing reputation for excellence.

As part of "The Lead" Jason talks with Associate Professor of Medicine from Northwestern University Feinberg School of Medicine Dr. Mark Sala about vaccines under attack, needing a prescription to get one, the change in distribution, stopping cancer research and more.

This hour Jason talks about vaccines under attack with Associate Professor of Medicine from Northwestern University Feinberg School of Medicine, he talks Twins with Dan Hayes from The Athletic, and we have DeRush Hour Headlines.

In today's OncClub episode, we had the pleasure of speaking with Shailee S. Shah, MD, about a retrospective study she and colleagues conducted to understand the effect of immune checkpoint inhibitors on patients with cancer and pre-existing neurologic autoimmune diseases, including multiple sclerosis, myasthenia gravis, Guillain-Barre syndrome, and Parkinson's disease. Dr Shah is a clinical assistant professor of neurology (MS/neuroimmunology) at the Northwestern University Feinberg School of Medicine in Chicago, Illinois.  In our exclusive interview, Dr Shah discussed the design of this study, key findings, and how these results emphasize the need for multidisciplinary care and risk stratification for more effective and comprehensive patient care.  Check out the full OncClub subseries to see additional findings and insights from this research!

Can you prevent cervical cancer? How do you prevent cervical cancer? Can I check for cervical cancer at home? Who should get screened for cervical cancer? Does the HPV vaccine work? Our guest is Ritu Nayar, MD, professor of pathology and medical education and executive vice chair of pathology at Northwestern University Feinberg School of Medicine. In this episode, Dr. Nayar talks about where cervical cancer rates are on the rise and how new screening tools can help reverse that trend. American Medical Association CXO Todd Unger hosts.

Katie Watson is a professor of medical education, medical social sciences, and obstetrics and gynecology at the Northwestern University Feinberg School of Medicine. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. K. Watson. Brain Death in Pregnancy — Abortion, Advance-Directive, or End-of-Life Law? N Engl J Med 2025;393:313-315.

BUFFALO, NY – June 20, 2025 – A new #review was #published in Volume 16 of Oncotarget on June 10, 2025, titled “Beyond DNA damage response: Immunomodulatory attributes of CHEK2 in solid tumors.” In this paper, led by first author Helen Qian and corresponding author Crismita Dmello from Northwestern University Feinberg School of Medicine, researchers compiled growing evidence that the CHEK2 gene, long known for its role in repairing DNA damage, may also influence how tumors respond to immunotherapy. Their analysis suggests that problems in CHEK2 function might make cancer cells more vulnerable to immune system attacks, highlighting a new opportunity to improve treatment outcomes in solid tumors. Immune checkpoint inhibitors (ICIs) have transformed cancer treatment; however, they are effective in only a subset of patients. This review suggests that tumors with reduced CHEK2 activity may accumulate more mutations that produce signals the immune system can recognize. These signals, known as neoantigens, help immune cells identify and destroy cancer cells more effectively. The review connects this process not only to CHEK2's established role in the DNA damage response but also to a newly proposed function in shaping the immune environment of tumors. CHEK2 normally helps maintain genomic stability by enabling precise DNA repair. When this function is lost, cells rely on more error-prone repair methods, leading to additional mutations. These mutations can increase tumor mutational burden, which has been linked to better outcomes with immunotherapy. Beyond DNA repair, the review highlights a second mechanism: activation of the cGAS-STING pathway. This pathway detects fragments of damaged DNA and triggers inflammation that attracts immune cells to the tumor. The authors highlight studies where CHEK2-deficient tumors responded better to PD-1 inhibitors, a common type of immune checkpoint inhibitor. In both lab models and early-stage clinical settings, CHEK2 loss was associated with increased infiltration of CD8+ T cells—immune cells essential for attacking cancer cells. In cancers such as glioblastoma and renal cell carcinoma, which are typically resistant to immunotherapy, reduced CHEK2 expression was linked with more favorable immune activity and higher expression of interferon-related genes. The compiled evidence points to CHEK2 as a potential biomarker for identifying patients likely to respond to immunotherapy. In addition, combining CHEK2 inhibitors with existing immunotherapies may enhance anti-tumor effects, particularly in cancers with limited treatment options. The review notes that some clinical trials using the CHEK1/2 inhibitor prexasertib alongside immune checkpoint therapies have already shown promising early results. “The initial results from this Phase I clinical trial support the immunomodulatory role of CHEK2 expression and even suggest CHEK2 potentiates immunosuppression.” Although more research is needed to confirm these mechanisms and improve treatment approaches, this review underscores the expanding role of DNA repair genes like CHEK2—not only in maintaining genome integrity but also in helping the immune system fight cancer. DOI - https://doi.org/10.18632/oncotarget.28740 Correspondence to - Crismita Dmello - stellacpak@outlook.com Video short - https://www.youtube.com/watch?v=C26pEBc0itk Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

Dr. Susan Quaggin, Chair of Department of Medicine at Northwestern University Feinberg School of Medicine, joins Lisa Dent to discuss concerns over federal funding being frozen by the Trump administration. Dr. Quaggin shares that across the entirety of Northwestern University, nearly 1,300 grants have been frozen, with 400 grants being frozen in the Department of […]

In this episode of Research Renaissance, host Deborah Westphal welcomes Dr. Yvette Wong, Assistant Professor of Neurology at Northwestern University and 2024 Toffler Scholar, for a deep dive into the dynamic inner world of cells—and how her lab is uncovering new clues about neurodegenerative diseases by studying the microscopic interactions between organelles.Dr. Wong discusses how organelles like mitochondria and lysosomes don't just function in isolation—they actually “talk” to each other at contact points within cells. These cellular conversations may hold the key to unlocking better understanding and treatments for conditions like ALS, Parkinson's, and Huntington's disease.Through vivid analogies (like buses exchanging cargo), Dr. Wong helps translate complex science into clear visuals, while also highlighting how advances in super-resolution live-cell microscopy and data analysis are transforming what's possible in neuroscience.

In this enlightening conversation, Meg Rittmanic hosts Douglas and Fiona Phillips, a couple celebrating 50 years of marriage. They discuss the profound partnership in their relationship, the spiritual depth of Fiona's art. The couple shares personal challenges, including a health crisis in their family, and how they navigated these together. Fiona's passion for mental health awareness is highlighted through her art, and they explore the symbolism in her painting 'Firstborn,' depicting Heavenly Mother and Father. Doug shares a poetic reflection on divine design, emphasizing the importance of recognizing the roles of both Heavenly Parents in our lives. In this conversation, Meg, Doug, and Fiona explore the themes of love, compassion, and the divine feminine, particularly focusing on the role of Heavenly Mother in their lives and relationships. They discuss the foundational principles that have allowed their marriage to flourish over 50 years, acknowledging the diverse experiences of others in relationships. The conversation emphasizes the importance of agency, personal growth, and the evolution of understanding within the Church regarding Heavenly Mother, while also recognizing the need for voices to speak out about these experiences.Fiona Phillips is a retired art professor, proud mom of five, and grandma to 13 wonderful grandkids. She is blessed to be married to Douglas, the love of her life! Originally from England, she moved to California with her family when she was just a pre-teen. Her art studio focuses on themes of water, women, nostalgia, and spirituality. One of her standout projects focused on raising awareness of the stigma surrounding mental illness was shown at DSU, Art Access Gallery and the OMA. She created 50 large portraits of adults, teens, and children, many of whom were personally affected by mental health challenges. Fiona's paintings explore themes of faith, our relationship to our Heavenly Parents, and our equality as children of God. Her work has been featured in three International Art Exhibitions by The Church. her paintings and poetry have been published in The Ensign, Liahona, and Exponent II magazines. Most recently Fiona has shown with the Oceanside Museum of Art, the Restore Conference, the Compass Gallery and galleries in California.She's earned numerous “Best of Show” awards and has had solo exhibits in Utah, California, Nevada, and Arizona. She has also earned two master's degrees—an MA in Humanities/Art and an MFA in Visual Art.Dr. Douglas Phillips is a multifaceted individual whose journey blends faith, music, medicine, and a deep connection to his roots. Born and raised in Southern California,Douglas joined the Church of Jesus Christ when he was 18 then embarked on a mission to Spain, an experience that deeply influenced his personal and professional life. Shortly after his return he was married to Fiona, his high school sweetheart.Before pursuing medicine, Dr. Phillips was immersed in the music scene, playing piano and writing songs for a pop music group. This creative outlet honed his discipline and collaborative skills, which would later serve him well in his medical career.He earned his Doctor of Medicine degree from Northwestern University Feinberg School of Medicine , followed by radiology specialty training at the University of California, San Francisco.Now retired, Dr. Phillips enjoys life in Southern California, where he continues to explore his passions and contribute to his community. His unique blend of experiences offers a rich perspective on the intersections of faith, creativity, and medicine.Douglas and Fiona have served 2 senior missions together, a member/leader service mission in a Spanish Ward in West Valley UT and as the Area Mission Medical Advisor and Assistant serving the 9 mission units in Southern California.https://fionabphillips.com/https://fionabphillips.com/faith/https://www.patreon.com/c/InHerImagePodcast

Charting Pediatrics has created a space where community care meets real-world challenges. Whether we realize it or not, trauma-informed care touches everything we do as pediatricians. What does it mean to really be trauma-informed? How do we create safer, more supportive environments for everyone, especially those carrying invisible wounds? In this episode, we explore how community providers can be a powerful part of healing, not harm. This episode was recorded on the exhibit floor at the 2025 Pediatric Academic Societies Conference in Honolulu, Hawaii. Joining us for this episode is Audrey Brewer, MD, a pediatrician at Lurie Children's Hospital of Chicago. She is also an Assistant Professor of Pediatrics at the Northwestern University Feinberg School of Medicine. Some highlights from this episode include: How a trauma-informed approach can completely change outcomes for kids  The types of trauma pediatricians are most likely to encounter in their practice  The role of the pediatrician in the larger support network for a child dealing with trauma  Opportunities for systemic change within the medical field to improve care for traumatized children For more information on Children's Colorado, visit: childrenscolorado.org. 

In this episode of Voices of Otolaryngology, join Rahul K. Shah, MD, MBA, AAO-HNS/F Executive Vice President and CEO as he interviews Dana M. Thompson, MD, MS, MBA, AAO-HNS 2024 Hall of Distinction inductee and Division Head of Otorhinolaryngology-Head and Neck Surgery and the Lauren D. Holinger Professor and Chair of Pediatric Otolaryngology at the Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, about transforming "pipelines" into "pathways" for diversity in medicine.  Discover her five guiding values and learn how her family legacy shaped her commitment to addressing healthcare disparities through mentorship, inclusion, and value-based care reforms. This episode was recorded during The Triological Society 2025 Combined Sections Meeting, January 23-25, 2025, in Orlando, Florida. 

It could be argued that agents of capitalism have built the patriarchal system as a means to keep both men and women controlled and in line. But what if we broke free? What would happen to sex, love and freedom then? Dr. Kate Balesteri joins us to discuss what patriarchy actually is, how it hurts all genders, and how we (men, women and every gender) can take back our agency while heightening our authenticity and consciousness. You can find Dr. Kate Balestrieri at: https://www.modernintimacy.com/dr-kate-balestrieri-sex-therapist/ Facebook http://facebook.com/dr.katebalestrieri http://instagram.com/drkatebalestrieri Tiktok https://www.tiktok.com/@drkatebalestrieri Dr. Kate Balestrieri"s Bio: Dr. Kate Balestrieri, Psy.D., CSAT-S, is a Licensed Psychologist (Clinical and Forensic) in CA, FL, NY and IL. She is a Certified Sex Therapist, Certified Sex Addiction Therapist – Supervisor, and PACT III trained couples' therapist. Dr. Balestrieri earned her Doctorate of Clinical Psychology from the Illinois School of Professional Psychology, Chicago, and completed her Post-Doctoral Fellowship though the Northwestern University Feinberg School of Medicine, with a concentration in Forensic Psychology. In over 16 years of clinical experience, she has conducted clinical and forensic evaluations, provided expert witness testimony in court, and been a treatment provider in clinical, forensic, and correctional settings. The Founder of Modern Intimacy, Dr. Balestrieri is a passionate advocate for mental, relational and sexual health. Throughout her work, Dr. Balestrieri focuses on helping people build resilience and recovery from what ails them to move from a position of pain or discomfort to one of thriving, holistically in their lives. A sex positive provider and human, Dr. Balestrieri is dedicated to helping people have a more expansive and integrated relationship with sexuality. Dr. Balestrieri is a regular contributor for PopSugar, Poosh, YourTango, Psychology Today, House of Wise and has been featured in many other publications. She is also the host of the Get Naked with Dr. Kate podcast, on which she discusses mental health, sex and relationships. You can listen on Apple Podcasts, Spotify, iHeart Radio or anywhere you get your podcasts! How to find Sunny Megatron: Website: http://sunnymegatron.com Facebook http://facebook.com/sunnymegatron Twitter http://twitter.com/sunnymegatron Instagram http://instagram.com/sunnymegatron Tiktok https://www.tiktok.com/@sunnymegatron YouTube https://www.youtube.com/sunnymegatron American Sex Podcast https://open.spotify.com/show/2HroMhWJnyZbMSsOBKwBnk How to find Kate Loree: Website http://kateloree.com Instagram: http://instagram.com/opendeeplywithkateloree Tiktok: https://www.tiktok.com/@opendeeplywithkateloree Facebook: https://www.facebook.com/kateloreelmft Twitter http://twitter.com/kateloreelmft YouTube https://youtube.com/channel/UCSTFAqGYKW3sIUa0tKivbqQ Book referenced: How to find Sunny Megatron: Website: http://sunnymegatron.com Facebook http://facebook.com/sunnymegatron Twitter http://twitter.com/sunnymegatron Instagram http://instagram.com/sunnymegatron Tiktok https://www.tiktok.com/@sunnymegatron YouTube https://www.youtube.com/sunnymegatron American Sex Podcast https://open.spotify.com/show/2HroMhWJnyZbMSsOBKwBnk How to find Kate Loree: Website http://kateloree.com Instagram: http://instagram.com/opendeeplywithkateloree Tiktok: https://www.tiktok.com/@opendeeplywithkateloree Facebook: https://www.facebook.com/kateloreelmft Twitter http://twitter.com/kateloreelmft YouTube https://youtube.com/channel/UCSTFAqGYKW3sIUa0tKivbqQ Book referenced: What Happened to My Sex Life?: A Sex Therapist's Guide to Reclaiming Lost Desire, Connection, and Pleasure by Dr. Kate Balestrieri Open Deeply podcast is not therapy or a replacement for therapy. Open Deeply podcast is not therapy or a replacement for therapy.

Join Drs. Neil Skolnik and Sara Wettergreen in this episode as they discuss the importance of emotional wellbeing in overall health. They will explore the connection between mental health and diabetes, focusing on how managing a chronic condition can impact the emotional lives of people living with diabetes and their families. Special guest Dr. Kelsey Brzezinski will also join the conversation.   Please note that this episode includes discussions of sensitive topics, we encourage you to listen with care and understand that the American Diabetes Association® is not an organization that specializes in mental health and only seeks to bring awareness to factors that coincide with a diabetes diagnosis. If you are experiencing challenges seek the support of a licensed medical or mental health professional. Presented by: Neil Skolnik, MD, Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health, Abington, PA Sara Wettergreen, PharmD, BCACP, BC-ADM, Assistant Professor, Department of Clinical Pharmacy, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences; and Ambulatory Care Clinical Pharmacist, UCHealth Lone Tree Primary Care, Aurora, CO Kelsey Brzezinski, PhD, Pediatric Psychologist at Lurie Children's Hospital of Chicago, Assistant Professor of Psychiatry and Behavioral Sciences at Northwestern University Feinberg School of Medicine, Chicago, IL   Do you have questions or comments you'd like to share with Neil and Sara? Leave a message at (703) 755-7288. Thank you for listening, and don't forget to “follow” Diabetes Day by Day!   Additional resources: If you or a loved one are experiencing a mental health crisis, please call the 988 Suicide & Crisis Lifeline. SAMHSA mental health help line, which is a no-cost, confidential, 24/7, 365-day-a-year treatment referral and information service available at 1-800-662-HELP (4357). Check out the American Diabetes Association®'s newly updated Mental Health Provider Directory to find to find therapists who specialize in supporting people living with diabetes near you.  

Not sure what Minimal Disease Activity or MDA is and how it relates to psoriatic arthritis and your joints? Listen as rheumatologist Dr. Arthur Mandelin explains what MDA means. Join hosts Jeff Brown and LB Herbert as they discuss minimal disease activity in psoriatic arthritis with nationally recognized rheumatologist Dr. Arthur Mandelin who identifies what it is, factors that influence achieving MDA, how long it takes to reach, and the impact on selection of treatments. Dr. Mandelin also addresses fatigue associated with inflammation, and what the future holds for minimal disease activity in psoriatic arthritis. Whether you have psoriasis or psoriatic arthritis, this episode offers information to help you understand management goals set by your doctor and the importance of attaining minimal disease activity. Timestamps: (00:00) Intro to Psound Bytes & guest welcome rheumatologist Dr. Arthur Mandelin (02:23) What is minimal disease activity (MDA) (04:32) MDA in comparison to ACR response criteria (07:36) Criteria for reaching MDA (09:20) Positive and negative factors of MDA (11:25) Importance of reaching MDA within a specific time frame (17:34) Length of time to reach MDA (18:48) Selection of treatment options and psoriatic arthritis domains (23:51) Inflammation and fatigue (26:59) A look at the future of minimal disease activity in psoriatic arthritis: Reaching ACR 90 (29:09) Advancements in psoriatic arthritis: Finding disease markers (33:40 ) If you have psoriasis, be aware of your risk for psoriatic arthritis 4 Key Takeaways: There are various ways to measure minimal disease activity in psoriatic arthritis to assess how the disease impacts quality of life.   Attaining and keeping minimal disease activity low through use of different therapy options offers a chance for better bone and joint outcomes. Advancements in psoriatic arthritis include attaining ACR90 and the potential for identifying key markers that make treatment selection more targeted and individualized. Those who have psoriasis need to realize bone and joint pain, and swelling in the joints may be related to their psoriatic skin disease and seek appropriate help.  Guest Bio: Dr. Arthur Mandelin is an Associate Professor of Medicine at Northwestern University Feinberg School of Medicine and the Department of Medicine Division of Rheumatology. Dr. Mandelin launched Northwestern University's first training program in musculoskeletal ultrasonography for rheumatology fellows. He is an active participant in the REASON Group which is a multi-center research collaboration devoted to using ultrasound guidance to obtain minimally invasive synovial tissue biopsies. Dr. Mandelin is a past member of the National Psoriasis Foundation's Medical Board where he served on consensus panels for the development of a variety of practice guidelines.  Resources Mentioned: National Psoriasis Foundation: https://www.psoriasis.org PEST Screener: https://www.psoriasis.org/psoriatic-arthritis-screening-test/ PsA Action Month 2025: https://www.psoriasis.org/psa-action-month/ NSAIDS  for Psoriatic Disease: https://www.psoriasis.org/advance/nsaids-for-psoriatic-disease-psa/ AMP (Accelerated Medicines Partnership): https://www.psoriasis.org/advance/progress-and-success- through-collaboration/  Tags: psoriasis, skin, psoriatic arthritis, minimal disease activity, ACR20, ACR50, ACR70, tender joints, bone erosion, joint swelling, enthesitis, inflammation, pain, fatigue, axial disease, spinal involvement, treatment, NSAIDS, biologics, personalized medicine, dermatology, National Psoriasis Foundation, AMP, Psound Bytes podcast, Soundbites podcast

 If you've been struggling with chronic idiopathic constipation (CIC), you know that traditional laxatives don't always work consistently—and they're not always ideal for long-term use. But what if there was a drug-free, FDA-cleared alternative designed to support your body's natural rhythm? In this episode, we welcome back Dr. Darren Brenner, gastroenterologist and motility expert from Northwestern University Feinberg School of Medicine, to explore the Vibrant capsule—a new non-drug treatment that uses gentle vibrations to stimulate natural gut motility. Tune in as we discuss: What makes Vibrant different from traditional constipation treatments  Who may benefit most from this new approach How it works with the body—not against it What this could mean for the future of constipation care As always, speak with your healthcare provider to determine if the Vibrant capsule is right for you.  

(Editor's note: Apologies for the mild echo!)TL;DR: The application deadline for the 2025-2026 cohort of LearnSkin's Integrative Dermatology Certificate Program (IDCP) is April 21st, 2025!As a proud and transformed IDCP alumnus, I know how this program helps dermatologists expand their approach to patient care and reignite their passion for dermatology.From evidence-informed functional medicine to new treatment strategies, IDCP provides practical tools to enhance how we support our patients with the comprehensive, holistic dermatology care I know so many of them are seeking.If you want to join and learn form a forward thinking, supportive, growth-minded community and expand your dermatology toolkit, opportunity is knocking... will you answer?

Dr. Bessey Geevarghese, Assistant Professor of Pediatrics-Infectious Diseases with Northwestern University Feinberg School of Medicine, joins Lisa Dent on the show to break down details surrounding the invasive Group A Streptococcal infections that are on the rise in the U.S.

In collaboration with the Women in Otolaryngology (WIO) Section of the American Academy of Otolaryngology Head and Neck Surgery. Join me as I discuss The Double Bind with Dana Thompson, MD, the Lauren D. Holinger Professor and Division Head of Pediatric Otolaryngology at Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine.

In this episode, we're diving into the latest ACG Clinical Guideline for the Diagnosis and Management of Eosinophilic Esophagitis (EoE)—a major update that reflects the most current understanding of this chronic, immune-mediated disease. Joining us to break it all down are two of the experts who co-authored these guidelines: Dr. Amanda B. Muir, Pediatric Gastroenterologist at The Children's Hospital of Philadelphia Dr. Nirmala Gonsalves, Gastroenterologist at Northwestern University Feinberg School of Medicine What We Cover: What is EoE? Understanding symptoms and diagnosis Key updates in the latest guidelines and what they mean for patients Treatment options for both children and adults Whether you're living with EoE, caring for someone with it, or simply want a deeper understanding of this condition, this episode is for you! This episode is brought to you by Sanofi, and presented in collaboration with the American College of Gastroenterology's Patient Care Committee.

Sex changes as we age. While these changes are often small and gradual, once you hit your 40s and 50s, it's not uncommon to start noticing bigger changes. In this episode, we’re going to talk all about sex at midlife and some of the most common sexual issues that come up during this time for women, as well as tips for dealing with them. My guest today is Dr. Sameena Rahman, a board-certified OB/GYN, sex-med gynecologist, and menopause specialist with an academic affiliation at Northwestern University Feinberg School of Medicine. She is the founder of the Center for Gynecology and Cosmetics, and host of the podcast Gyno Girl Presents: Sex, Drugs & Hormones. Some of the specific topics we explore include: What are some of the most common sexual challenges faced by midlife women? Why is it so taboo to talk about midlife sexual distress? What do women need to know about how peri-menopause can affect your sex life? What are the most helpful strategies for improving sex at midlife? How can self-pleasure help in relieving peri-menopause symptoms? You can follow Sameena on Instagram to stay updated on her work. Got a sex question? Send me a podcast voicemail to have it answered on a future episode at speakpipe.com/sexandpsychology. *** Thank you to our sponsors!  Passionate about building a career in sexuality? Check out the Sexual Health Alliance. With SHA, you’ll connect with world-class experts and join an engaged community of sexuality professionals from around the world. Visit SexualHealthAlliance.com and start building the sexuality career of your dreams today. *** Want to learn more about Sex and Psychology? Click here for previous articles or follow the blog on Facebook, Twitter, or Bluesky to receive updates. You can also follow Dr. Lehmiller on YouTube and Instagram. Listen and stream all episodes on Apple, Spotify, Google, or Amazon. Subscribe to automatically receive new episodes and please rate and review the podcast!

Claim your complimentary gift of my exclusive mini weight care guide today!Link: Weight Care Guide — Dr. Francavilla Show (thedrfrancavillashow.coWith the recent release of The Lancet's consensus article, the conversation around obesity treatment and care is evolving. To explore the implications of this shift, I'm joined by Dr. Robert Kushner, a respected expert in the field who has dedicated his career to advancing obesity medicine.Dr. Kushner is a professor at Northwestern University Feinberg School of Medicine and the author of over 250 publications and several books on nutrition and obesity. He also co-founded the American Board of Obesity Medicine, contributing to the foundation of obesity care. His latest book, Patient-Centered Weight Management, offers healthcare professionals practical insights. With his extensive experience, Dr. Kushner continues to shape the direction of obesity treatment.In this discussion, we examine the differences between clinical and preclinical obesity and address the important question: should preclinical obesity be treated? Dr. Kushner also explains why a new approach to obesity assessment is essential for the future of healthcare.Be sure to stick around until the end for my takeaways and thoughts on how this impacts healthcare. Want to dive deeper into this discussion? Tune into the full episode and let's unpack it all together!Connect with Dr. Kushner:Website: https://drrobertkushner.com/Connect with me:Instagram: doctorfrancavillaFacebook: Help Your Patients Lose Weight with Dr. FrancavillaWebsite: Dr. Francavilla ShowYoutube: The Doctor Francavilla ShowGLP Strong: glpstrong.com

Show notes: (0:48) Dr. Mark Rosenbloom and his mission (2:54) The ABCs for health optimization (8:39) APOE and COMT genes: Why they matter (14:30) Hormone therapy benefits across all ages (23:19) The Mediterranean diet and avoiding harmful foods (30:07) Follistatin gene therapy and rapamycin (43:03) How to find Dr. Rosenbloom and work with him (46:36) Outro Who is Dr. Mark Rosenbloom?   Dr. Rosenbloom is the CEO and Chief Medical Officer at LIFEFORCE Medical Institute. He began his training at Stanford University and attended Northwestern University Feinberg School of Medicine where he won the Dean's AOA Research Award and the prestigious Sigmund Winton Award in Biochemistry. Thereafter, he went on to become an Instructor and Assistant Professor of Clinical Medicine in the Department of Medicine at Northwestern University. More recently, Dr. Rosenbloom trained at the Cenegenics Education and Research Foundation and founded LIFEFORCE Medical Institute which focuses his practice on anti-aging and Bio-Identical Hormone Replacement Therapy(BHRP).   Dr. Rosenbloom is also the Founder of PEPID LLC, which is recognized as the number one developer of medical/drug information and decision support tools. PEPID is now used in schools and institutions worldwide for better risk management and higher productivity to benefit both the staff and patients. Dr. Rosenbloom has also been the Editor of "Your Health Magazine" and has been published in print and media on various topics such as age management, low testosterone for men, BHRT, medical errors, and vitamin toxicity.   An active organization member of the philanthropic community, Dr. Rosenbloom is the founder of Unicorn Children's Foundation, an organization dedicated to helping children and young adults with developmental, communication and learning disorders such as autism and ADD. In addition, he is also a Founding Member of the Interdisciplinary Council on Developmental and Learning Disorders. Dr. Rosenbloom is passionate about this cause and has publically spoken multiple times regarding Autistic-Spectrum Disorders in Children, including numerous network TV appearances in Miami, Boca Raton and Palm Beach, Florida. Connect with Dr. Rosenbloom: Website: https://www.lifeforcemed.com/ Links and Resources: Peak Performance Life Peak Performance on Facebook Peak Performance on Instagram  

Voters backed enhanced election security, healthcare coverage for IVF and a so-called millionaire's tax to fund property tax relief. Reset learns more about two of the proposals with former Democratic Illinois governor Pat Quinn and Lindsay Allen, assistant professor of emergency medicine at the Northwestern University Feinberg School of Medicine.

If you're on the hunt for steroid-free itchy scalp remedy options to end the embarrassment and discomfort of flaky, itchy scalp problems, this episode is for you.From cradle cap in infants to itchy, crusty, flaky dandruff in adults, so many people feel like they've tried every dandruff treatment in the book. From medicated anti-dandruff shampoo to topical steroids and other medications, you know that eventually, the flaking, itching, and redness all return.This is because those treatments don't deal with the root of the issue, which is an imbalanced scalp microbiome, leading to an overgrowth of things like malassezia.AND a compromised skin barrier, which can be a trigger for the atopic march (food allergies, dry skin, allergic rhinitis, eczema, and asthma).Joining me to discuss how to get rid of dandruff, cradle cap removal, and her line of gentle scalp rebalancing products is return guest Ruchi Gupta, MD, MPH. She is a Professor of Pediatrics and Medicine at Northwestern University Feinberg School of Medicine and a Clinical Attending at Ann & Robert H. Lurie Children's Hospital of Chicago.Dr. Gupta has over 20 years of experience as a board-certified pediatrician and health researcher and currently serves as the founding director of the Center for Food Allergy & Asthma Research (CFAAR).She is world-renowned for her research on the epidemiology, economic impact, prevention, and management of allergic conditions, and strives to find answers and shape policies surrounding these conditions in order to reduce burden and improve health equity.In This Episode:Why Dr. Gupta sought out an effective itchy scalp remedyWhat is cradle cap? (+ cradle cap removal options)Why scalp issues in babies could trigger food allergiesDandruff causes (+ how the scalp microbiome is involved)How Yobee hair products workThoughts on hair products causing MORE scalp inflammationWho can use Yobee products? (Can you use it for beardruff + beard care?)Quotes“So for the scalp, typically your cells should regenerate every month. And what happens when you have dandruff, it's happening more frequently and that's where you're getting those white flakes. So it's happening almost weekly. And what's causing that? So many things. So we all use different hair products now and a lot of the hair products have chemicals in it. And so what are those chemicals doing to disrupt the microbiome? You have to think about that.”“Eczema and the cradle cap and food allergies and allergic rhinitis and asthma, they're all connected. And so if you have one, you have a higher chance of having the rest. So those babies with eczema, just like my daughter, develop food allergies. But now we're seeing more and more, like a lot of the creams or, like you said, shampoos will have a food component and that could be causing that food allergy to start up because it's entering them through their skin.”LinksFind Dr. Gupta online | Instagram | Instagram | Facebook | Facebook | Twitter | TwitterFind Yobee online and on InstagramGet Dr. Gupta's book,