PreScrippsion Sound

The fifth and final episode in our healthy aging series. We discover what happens inside the cell with age and how new chemical tools are leading us towards ways of repairing the damage and preserving our youth. This article is taken from the Summer 2021 of our award-winning Scripps Research Magazine. Show notes: Explore the Scripps Research Magazine https://magazine.scripps.edu/

The fourth segment of our series on healthy aging. We take a look at how breakthroughs in chemistry have enabled the rational design of therapies that can stop or slow complex diseases of the heart and nervous system. This article is taken from the Summer 2021 of our award-winning Scripps Research Magazine. Show notes: Explore the Scripps Research Magazine https://magazine.scripps.edu/

We roll on with part 3 of our healthy aging series. We examine the role of our DNA blueprint in the risk of cardiovascular disease, as well as how understanding our personal genetic risk scores could help us avoid that deadly heart attack. This article is taken from the Summer 2021 of our award-winning Scripps Research Magazine. Show notes: Explore the Scripps Research Magazine https://magazine.scripps.edu/

In the second of this series on healthy aging, we reveal how Scripps Research scientists are developing interventions to remove stiff, achy joints from the aging equation. This article is taken from the Summer 2021 of our award-winning Scripps Research Magazine. Show notes: Explore the Scripps Research Magazine https://magazine.scripps.edu/

Peer into the future of healthy aging. In this episode (the first of a 5-part series), we shed new light on how our cells and organs work together to influence longevity, and how newly discovered molecules may be able to block biological degeneration. This article is taken from the Summer 2021 of our award-winning Scripps Research Magazine. Show notes: Explore the Scripps Research Magazine https://magazine.scripps.edu/

Dr. Ed Ramos is director of Digital Clinical Trials for the Scripps Research Digital Trials Center. Listen as we talk about empowering the individual with wearable health devices, the worst foods for spiking our blood sugar and the importance of lifelong flexibility. Show notes: PROGRESS study enrollment https://progress.scripps.edu/ PROGRESS study explainer video https://www.youtube.com/watch?v=UUdaMojHLuk&t=74s Ed’s bio https://www.scripps.edu/science-and-medicine/translational-institute/about/people/ed-ramos/ Scripps Research Digital Trials Center https://digitaltrials.scripps.edu/

Another special edition featuring an extended conversation between Dr. Eric Topol, Director of the Scripps Research Translational Institute, and Professor Andrew Ward in the Department of Integrative Structural and Computational Biology at Scripps Research. Listen as they talk about structural biology as a gamechanger in coronavirus research, what makes the SARS-CoV-2 spike protein crucial for vaccine design, and what the latest coronavirus mutations mean for the pandemic. Show notes: The Ward Lab: https://ward.scripps.edu/ Dr. Eric Topol’s bio: www.scripps.edu/faculty/topol/ Inside the Lab That Invented the COVID-19 Vaccine: https://www.youtube.com/watch?v=-92HQA0GcI8&%3Bfeature=youtu.be Solving the spike protein’s 3D structure: https://www.scripps.edu/newsandviews/e_20160307/ward.html Science, Simplified: How vaccines work against COVID-19 https://youtu.be/uWGTciX795o Scripps Research on social media: Twitter, Instagram: @scrippsresearch Facebook: @ScrippsResearchInstitute LinkedIn: the-scripps-research-institute

Dr. Daphne Lurie is a California-licensed clinical psychologist and Director of the Counseling and Psychological Services (CAPS) on the Scripps Research La Jolla campus. Listen as we talk about the impact of the COVID-19 pandemic on mental health trends, using mindfulness to become more efficient and ziplining in Costa Rica. Show notes: Daphne’s Scripps Research profile: https://www.scripps.edu/about/campus-resources/counseling-and-psychological-services/about-us/ Counseling and Psychological Services (CAPS) at Scripps Research: https://www.scripps.edu/about/campus-resources/counseling-and-psychological-services/ Other mindfulness resources discussed: A Mindfulness-Based Stress Reduction Workbook - Bob Stahl, Elisha Goldstein The Mindful Self-Compassion Workbook - Kristin Neff, Christopher Germer

Stories brought to life! Today’s audio adventure comes from the Fall 2020 edition of our Scripps Research Magazine. We dive into the adaptations made by institute researchers during the COVID-19 pandemic to ensure both safety and continued scientific discovery. Show notes: Explore our Scripps Research Magazine and subscribe https://www.scripps.edu/news-and-events/connect-with-us/

Dr. Kara Marshall is based in the Department of Neuroscience at Scripps Research, working as a postdoctoral researcher in Professsor Ardem Patapoutian’s lab. Listen as we talk about the circuitry involved in urination, burst bladders and improv comedy. Show notes: The Patapoutian Lab https://patapoutianlab.org/ Kara’s recent discovery on bladder function https://www.nature.com/articles/s41586-020-2830-7 Deciphering how the body’s cells sense touch https://www.nature.com/articles/d41586-019-03955-w Proprioception: the silent ‘sixth’ sense https://www.vox.com/the-highlight/2019/11/22/20920762/proprioception-sixth-sense

Today’s special edition features an extended conversation between Dr. Eric Topol, Director of the Scripps Research Translational Institute, and Professor Dennis Burton, Chair of the Department of Immunology and Microbiology at Scripps Research. Listen as they talk about antibody cocktail treatments, the mystery of “longhaul” COVID-19 symptoms and how close we are to developing a coronavirus vaccine. Transcript of today's episode https://www.scripps.edu/covid-19/videos/topol-burton/index.html Dr. Eric Topol’s bio https://www.scripps.edu/faculty/topol/ Prof. Dennis Burton’s bio https://www.scripps.edu/faculty/burton/ Efficacy of convalescent plasma https://www.sandiegouniontribune.com/business/biotech/story/2020-08-30/hundreds-of-san-diegans-with-covid-19-have-already-been-treated-with-plasma-but-does-it-work “COVID longhaulers” https://www.theatlantic.com/health/archive/2020/08/long-haulers-covid-19-recognition-support-groups-symptoms/615382/ Coronavirus vaccine Q&A with Prof. Dennis Burton https://www.sandiegouniontribune.com/business/biotech/story/2020-07-26/q-a-an-update-on-the-race-for-a-covid-19-vaccine-scripps-research-immunologist-dennis-burton Dr. Eric Topol on social media: Twitter: @EricTopol Instagram: @erictopol1 Scripps Research on social media: Twitter, Instagram: @scrippsresearch Facebook: @ScrippsResearchInstitute LinkedIn: the-scripps-research-institute

Dr. Amanda Roberts is the Senior Scientific Director of the Mouse Behavioral Core at Scripps Research. Listen as we talk about microgravity as a model of accelerated aging, NASA’s top-secret agents and what happens to slime in space. (Image Credit: Andrew Roberts) Show notes: Amanda’s research profile: https://vivo.scripps.edu/display/RobertsAmanda Replay of the NASA launch (action around ~11 minutes in): https://www.cnbc.com/2019/07/25/spacex-livestream-watch-the-company-launch-nasa-crs-18-on-a-falcon-9.html News coverage of the NASA mouse studies: https://www.nasa.gov/feature/ames/studying-behavior-in-space-shows-mice-adapt-to-microgravity https://qz.com/1597197/nasas-space-station-mice-loved-microgravity/

Research discoveries brought to life! In today’s segment, we explore Scripps Research’s Natural Products Discovery Center, a historic natural collection that may hold the key to thousands of future therapies. This article is taken from the Fall 2019 edition of our Scripps Research Magazine. Show notes: Digital version of our Fall 2019 magazine: https://issuu.com/endeavor-scripps-research/docs/magazine_fall2019_pageflipper?embed_cta=read_more&embed_context=embed&embed_domain=www.scripps.edu Subscribe to receive the Scripps Research magazine: https://signup.e2ma.net/signup/1879047/1890109/ The Scientist: Scripps Research acquires Pfizer’s massive microbial library https://www.the-scientist.com/news-opinion/scripps-acquires-pfizers-massive-microbial-library-66923 West Palm Beach News: Local organization works to create new medicine https://www.wpbf.com/article/local-organization-works-to-create-new-medicine-scripps-research-jupiter/30813823 The Shen Lab: https://www.scripps.edu/shen/

Research discoveries brought to life! In today’s short story, we find out how medicines designed for our pets are now being repurposed by our scientists to provide a lasting, protective vaccine against Lyme disease. This article is taken from the Fall 2019 edition of our Scripps Research Magazine. Show notes: Digital version of the Scripps Research Fall 2019 magazine: https://www.scripps.edu/news-and-events/connect-with-us/magazine-current-issue/index.html Subscribe to receive the Scripps Research magazine: https://signup.e2ma.net/signup/1879047/1890109/ US News & World Report: The growth and reach of Lyme disease: https://www.usnews.com/news/healthiest-communities/articles/2019-12-10/lyme-disease-diagnoses-grow-in-private-insurance-claims

David Biello is an award-winning journalist and the scientific curator for TED. Listen as we talk about his favorite areas of science, how to craft a compelling narrative and being obsessed with blind cavefish. Show notes: David’s profile at TED (and book link) https://www.ted.com/speakers/david_biello David’s work at Scientific American https://www.scientificamerican.com/author/david-biello/ TED talk – ‘Clues to prehistoric times, found in blind cavefish’ https://www.ted.com/talks/prosanta_chakrabarty_clues_to_prehistoric_times_found_in_blind_cavefish TED talk – ‘What happens in your brain when you taste food’ https://www.ted.com/talks/camilla_arndal_andersen_what_happens_in_your_brain_when_you_taste_food Social media: Twitter: @dbiello Remember to follow @ScrippsResearch on Twitter, Instagram, Facebook and LinkedIn

Dr. Kristen Johnson is a lead investigator at Calibr, the drug discovery division of Scripps Research. Dr. Maria Millan is the President and CEO of the California Institute for Regenerative Medicine (CIRM). Listen as we talk about the world’s largest stem cell bank, restoring healthy cartilage to patients, and the advantages of non-profit research. Show notes: Kristen’s talk in the Scripps Research Front Row Lecture Series https://www.youtube.com/watch?v=WRzQniqUlHo&t=1941s Coverage of KA34 in the San Diego Union Tribune https://www.sandiegouniontribune.com/business/biotech/sd-me-scripps-cartilage-drug-arthritis-20180624-story.html Maria’s profile at CIRM https://www.cirm.ca.gov/about-cirm/cirm-leadership Social Media: Follow @ScrippsResearch on Twitter, Instagram, Facebook and LinkedIn Follow CIRM on Twitter:@CIRMnews ; Instagram:@cirm_stemcells ; Facebook: @California InstituteForRegenerativeMedicine

Dr. Brian Fiske is the Senior Vice President for Research Programs at the Michael J. Fox Foundation for Parkinson’s Disease. Professor Jeff Kelly is in the Department of Chemistry at Scripps Research. Listen as we talk about biomarkers for early disease detection, the importance of long-term human trials, and how Parkinson’s disease could originate in the gut. Show notes: Dr. Fiske’s bio at MJFF https://www.michaeljfox.org/foundation/leaders.html?subcatid=381 Prof. Kelly’s bio at Scripps Research https://www.scripps.edu/faculty/kelly/ Coverage of FDA approval of Tafamidis https://www.scripps.edu/news-and-events/press-room/2019/20190506-fda-approved-tafamidis.html https://www.fda.gov/news-events/press-announcements/fda-approves-new-treatments-heart-disease-caused-serious-rare-disease-transthyretin-mediated Social Media: Twitter/Instagram: @MichaelJFoxOrg Remember to follow @ScrippsResearch on Twitter, Instagram, Facebook and LinkedIn

Dr. Eric Topol is the Founder and Director of The Translational Institute at Scripps Research. Listen as we talk about bringing back empathy in medicine, smartphone ultrasounds and the best media for absorbing scientific information. Show notes: Translational Institute at Scripps Research https://www.scripps.edu/science-and-medicine/translational-institute/ Eric’s new book: Deep Medicine https://www.amazon.com/Deep-Medicine-Artificial-Intelligence-Healthcare/dp/1541644638 Current and future applications of technology in healthcare https://www.nature.com/articles/s41591-018-0300-7.pdf The Topol Review on the future of the NHS https://topol.hee.nhs.uk/ Eric’s 2016 Tedx Talk https://www.youtube.com/watch?v=y9nS1b7ifSE Twitter: @EricTopol Facebook: @ScrippsRTI Instagram: @erictopol1

Dr. Chatterjee is the Vice President of Medicinal Chemistry at Calibr, the biotechnology division of Scripps Research. Listen as we talk about re-purposing existing compounds for new diseases, the future of robotics in drug discovery and our favorite Superheroes. Show notes: About Calibr https://www.scripps.edu/science-and-medicine/calibr/about/index.html ReFRAME Initiative https://www.scripps.edu/news-and-events/press-room/2018/20181003-reframe-calibr.html Footage of Calibr’s robots in action https://www.statnews.com/2018/12/10/calibr-drug-compounds-mined-new-treatments/ Use of the ReFRAME library to treat Cryptosporidium infection https://www.pnas.org/content/115/42/10750

Matthias is based in the Department of Immunology and Microbiology at Scripps Research, working in Prof. Kristian Andersen’s Lab. Listen as we talk about wearable devices to monitor disease progression, research field-trips to West Africa and fancy nights at the symphony. **p.s. if you enjoyed the Christmas jingle, Matthias and I are currently working on an album** Show notes: Andersen Laboratory https://andersen-lab.com/ CViSB Consortium https://cvisb.org/ Burton Laboratory https://www.scripps.edu/burton/ @mpauthner on twitter @cvisb on twitter @mattmirabilis on Instagram

Alyssa is based in the Department of Molecular Medicine at Scripps Research, under the supervision of Prof. Joseph Kissil. Listen as we talk about cancer biology, naked mole-rats and practical tips for improving science communication. Show notes: Kissil Laboratory https://www.scripps.edu/kissil/ Alyssa’s blog https://thecurioussheep.net/blog/ @the_curioussheep on Instagram @_curioussheep on twitter

Prof. Miller is based in the Department of Molecular Medicine at Scripps Research. Listen as we talk about methamphetamine-use disorder, short- and long-term memory formation, and Breaking Bad. Show notes: Prof. Miller’s Scripps Research bio https://www.scripps.edu/faculty/miller/ Pearson Center for Alcoholism and Addiction http://www.pearsoncenter.org/laboratories-pearson-center/ News coverage of recent work https://eurekalert.org/pub_releases/2018-09/sri-ouc091418.php @millerlab3 on twitter

A compilation of interview highlights recorded live from the branding launch party at Scripps Research. I heard from scientists about how their work is changing life, and spoke with members of communications/marketing/philanthropy about what this new brand means for the institute and the wider community. Show notes: Scripps Research Community Events Calendar https://www.scripps.edu/news-and-events/events-calendar/ How To Connect With Scripps Research https://www.scripps.edu/news-and-events/connect-with-us/ “All of Us” Research Program at the Scripps Research Translational Institute https://www.scripps.edu/news-and-events/press-room/2018/20180501-medicine-all-of-us.html Calibr at Scripps Reseearch https://www.scripps.edu/science-and-medicine/calibr/ Grizzly Marketing Team https://madebygrizzly.com/

Prof. Gary Siuzdak is the Director of the Metabolomics Center at Scripps Research. Listen as we talk about using our own metabolites to impact health status, environmental estrogen-mimics and the potential benefits of Red Bull. Show notes: Metabolomics Center website https://masspec.scripps.edu/landing_page.php?pgcontent=mainPage Gary’s VIVO Scientific Profile https://vivo.scripps.edu/display/SiuzdakGary News coverage of xenoestrogen work https://www.sciencedaily.com/releases/2018/01/180111155106.htm https://www.telegraph.co.uk/science/2018/01/11/breakthrough-breast-cancer-drug-thwarted-chemical-found-bread/ News coverage of oligodendrocyte work https://www.eurekalert.org/pub_releases/2017-12/sri-tlh120817.php

Dr. Peterson is an Assistant Professor in the Department of Nutrition Sciences at the University of Alabama at Birmingham. Listen as we talk about different fasting strategies, the big bang and the importance of our biological rhythms. Show notes: Dr. Peterson’s UAB Bio https://www.uab.edu/shp/nutrition/about-the-department/faculty-and-staff/primary-faculty/160-courtney-m-petersonProject Time Restricted-Feeding Blog Post http://blog.mycircadianclock.org/early-time-restricted-feeding-for-the-prevention-of-diabetes/ Dr. Peterson’s Coverage in the Washington Post https://www.washingtonpost.com/national/health-science/timing-your-meals-may-help-with-weight-loss-thats-what-it-seems-to-do-in-mice/2018/03/23/14672fc0-f718-11e7-a9e3-ab18ce41436a_story.html?noredirect=on&utm_term=.af64ab9e5818 Dr. Peterson’s Pilot Study of TRF in Prediabetes https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30253-5

Tod Williams and Billie Tsien are the architects responsible for designing what was formerly the Neurosciences Institute (NSI); the buildings now make up the Hazen Campus and serve as the focal point of The Scripps Research Institute. Listen as we talk about the history of the build, common motifs for all science buildings and the importance of afternoon tea. Show notes: Tod Williams and Billie Tsien bios http://www.twbta.com/studio/people/tod-williams-billie-tsien Project Images of the building complex http://www.twbta.com/6675 2017 LongHouse Award https://www.archdaily.com/805628/tod-williams-plus-billie-tsien-win-2017-longhouse-award-discuss-design-ideas-for-obama-presidential-library 2013 National Medal of Arts Award https://www.arts.gov/honors/medals/billie-tsien-and-tod-williams In memoriam: Gerald Edelman https://www.scripps.edu/newsandviews/e_20140602/edelman.html

Steve is the Director of Digital Medicine at the Scripps Translational Science Institute (STSI). Listen as we talk about Fitbits, perverse healthcare incentives and hiking to Mount Everest Base Camp. Show notes: Steve’s bio at STSI https://www.stsiweb.org/about/faculty/steinhubl-steven/ STSI Precision Medicine Initiative https://www.stsiweb.org/translational-research/precision-medicine-initiative/ DIGIMED 2017 conference program https://www.stsiweb.org/event/digimed17/digimed17-program/ Nature Digital Medicine Journal https://www.nature.com/npjdigitalmed/

Matt is the Vice President of Business Development at TSRI, as well as Chief Operating Officer at Calibr. Listen as we talk about what constitutes commercially valuable research, why TSRI is #1 for science innovation and how to design a home jungle gym. Show notes: Matt’s recent Biocom Catalyst Award http://www.scripps.edu/newsandviews/i_20171002/20171002tremblay_biocom.html?utm_source=newsviews&utm_medium=email&utm_campaign=internal20171002 Calibr Bio http://www.calibr.org/about/institute-leadership/ TSRI-Calibr partnership https://www.eurekalert.org/pub_releases/2016-10/sri-tac102016.php

Arthur is based in the department of integrative structural and computational biology at TSRI. Listen as we talk about HIV modelling, hexbug toys and human avatars. Show notes: Olson Lab website http://mgl.scripps.edu/ HIVE center http://hive.scripps.edu/ 3D printed demo of viral self-assembly https://www.youtube.com/watch?v=br-YxeXWx6s AR + 3D models to understand molecular interfaces https://www.youtube.com/watch?v=gZxK6j4JTHQ

Formerly of TSRI, Lynda is now part of a local start-up. Listen as we talk about industry pros and cons, endurance athletics and Richard Branson. Show notes: Abilita Bio company website http://www.abilitabio.com/ Biotechnology and networking resources SDBN – San Diego Biotechnology Network http://sdbn.org/   LSN – Life Science Network http://lifesciencenetwork.com/home   SDEE – San Diego Entrepreneurs Exchange http://www.sdentrepreneurs.org/   FBB – French Bio Beach http://frenchbiobeach.com/ WIB – Women In Bio http://www.womeninbio.org/   CLSA – California Life Science Association http://califesciences.org/   Two Scientists Walk into a Bar http://www.rhfleet.org/events/two-scientists-walk-bar   Suds and Science http://www.rhfleet.org/events/suds-science   Spotlight on JLABS http://jlabs.jnjinnovation.com/