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MONEY FM 89.3 - Prime Time with Howie Lim, Bernard Lim & Finance Presenter JP Ong
Deep Insight Labs is a Singapore-based AI company transforming the way investment research is done. Founded by former quantitative researchers and enterprise AI specialists, the company builds AI research assistants designed specifically for finance professionals from hedge funds and asset managers to wealth advisors and family offices. Unlike generic chatbots or black-box models, Deep Insight Labs creates tools that analysts can trust, preserving human judgment, domain expertise, and decision-making rigor while automating repetitive, time-consuming tasks. On The Right Business, Nadiah Koh speaks to Ryan, Founder of Deep Insight Labs, about how the company is transforming investment research and helping analysts work smarter. See omnystudio.com/listener for privacy information.
How is PepsiCo reshaping its future while staying true to the brands consumers love? In this episode, host Matt Mueller sits down with Michael Del Pozzo, President of PepsiCo North America, to explore the company's bold new chapter. They discuss: - How PepsiCo balances data-driven precision with creative instinct - What's fueling innovation across beverages, snacks, and brand refreshes - How “One PepsiCo” is accelerating speed, collaboration, and retail partnerships Join the conversation with our global retail community at www.globalretailleaders.com
On this episode of Zen and the Art of Real Estate Investing, Jonathan welcomes Benjamin Kanner, CEO and co-founder of 3V Infrastructure, a company focused on delivering long-term, scalable EV charging solutions for multifamily portfolios. With a background spanning commercial real estate, renewable energy project finance, and multiple startups, Ben brings a uniquely holistic view of how electrification intersects with property ownership and investor demand. His company's model—installing, owning, and operating EV chargers at no cost to property owners—creates a compelling new amenity for renters while helping owners stay ahead of rapidly shifting consumer expectations. Throughout the conversation, Ben and Jonathan discuss the accelerating adoption of electric vehicles, why multifamily properties sit at the center of this transition, and the economic forces shaping the need for reliable, long-dwell charging infrastructure. Ben explains the cost drivers behind EV ownership, how modular battery technology is evolving, and why Level 2 charging is the most practical option for home-based needs. He also breaks down how 3V underwrites utilization, diversifies risk across large portfolios, and helps property owners increase rents and tenant satisfaction—all without capital outlay. Listeners will gain a deeper understanding of how EV charging impacts NOI, what's really happening with power demand, why used EV markets will expand rapidly, and how owners can prepare their buildings for the next decade of transportation needs. Whether you're an LP, a multifamily operator, or simply curious about electrification, this episode highlights the strategic advantage of early adoption. In this episode, you will hear: Why EV adoption has crossed a national inflection point and what that means for multifamily owners. How 3V Infrastructure finances, installs, and maintains EV chargers with no upfront cost to operators. The economics of EV ownership—including maintenance, fueling costs, and battery modularity. Why Level 2 charging is ideal for long-dwell environments like apartment communities. The role of data, utilization modeling, and EV "rent rolls" in determining charger counts. How electrification, grid demand, and infrastructure investment will shape the next decade of CRE. Follow and Review If you enjoy the show, please follow Zen and the Art of Real Estate Investing on Apple Podcasts and leave a rating and review. It helps other listeners discover these conversations and supports the show's growth. Supporting Resources Connect with Benjamin: Website: https://www.3vinfrastructure.com/ Connect with Jonathan: Website - www.streamlined.properties YouTube - www.youtube.com/c/JonathanGreeneRE/videos Instagram - www.instagram.com/trustgreene Instagram - www.instagram.com/streamlinedproperties Zillow - www.zillow.com/profile/streamlinenj Bigger Pockets - www.biggerpockets.com/users/jonathangreene Facebook - www.facebook.com/streamlinedproperties Email - info@streamlined.properties This episode was produced by Outlier Audio.
Extinction Rebellion's co-founder Clare Farrell and conservation scientist Dr Charlie Gardner team up once more to discuss issues and stories they feel are not getting enough airtime. They want to make sure that the latest news in science and important reports that are relevant to the climate and ecological crisis are flagged and explained in ways that are easy to understand. EPISODE 29: CO2 accelerating, corals gone forever, is it time to start geoengineering?In this episode Charlie explains the recent measurement of accelerating atmospheric CO2 concentrations in the atmosphere as well as the announcement that coral bleaching has passed a tipping point, while Clare delves into the world of solar radiation management at a recent conference she attended with James Hansen.REFERENCESRecord leap in CO2 concentrations - The Guardianwww.theguardian.com/environment/2025/oct/15/record-leap-in-co2-fuels-fears-of-accelerating-global-heatingJames Hansen & Clare Farrell - Climate Reckoning in ATLAS25, Operaatio Arktishttps://www.youtube.com/watch?v=Y2UME_Z8oig --------------------- Please, share, comment, subscribe, like, mobilise, and donate! https://chuffed.org/xr/uk
In this second part of my three-part series (catch Part I via episode 182), I dig deeper into the key idea that sales in commercial data products can be accelerated by designing for actual user workflows—vs. going wide with a “many-purpose” AI and analytics solution that “does more,” but is misaligned with how users' most important work actually gets done. To explain this, I will explain the concept of user experience (UX) outcomes, and how building your solution to enable these outcomes may be a dependency for you to get sales traction, and for your customer to see the value of your solution. I also share practical steps to improve UX outcomes in commercial data products, from establishing a baseline definition of UX quality to mapping out users' current workflows (and future ones, when agentic AI changes their job). Finally, I talk about how approaching product development as small “bets” helps you build small, and learn fast so you can accelerate value creation. Highlights/ Skip to: Continuing the journey: designing for users, workflows, and tasks (00:32) How UX impacts sales—not just usage and adoption(02:16) Understanding how you can leverage users' frustrations and perceived risks as fuel for building an indispensable data product (04:11) Definition of a UX outcome (7:30) Establishing a baseline definition of product (UX) quality, so you know how to observe and measure improvement (11:04 ) Spotting friction and solving the right customer problems first (15:34) Collecting actionable user feedback (20:02) Moving users along the scale from frustration to satisfaction to delight (23:04) Unique challenges of designing B2B AI and analytics products used for decision intelligence (25:04) Quotes from Today's Episode One of the hardest parts of building anything meaningful, especially in B2B or data-heavy spaces, is pausing long enough to ask what the actual ‘it' is that we're trying to solve. People rush into building the fix, pitching the feature, or drafting the roadmap before they've taken even a moment to define what the user keeps tripping over in their day-to-day environment. And until you slow down and articulate that shared, observable frustration, you're basically operating on vibes and assumptions instead of behavior and reality. What you want is not a generic problem statement but an agreed-upon description of the two or three most painful frictions that are obvious to everyone involved, frictions the user experiences visibly and repeatedly in the flow of work. Once you have that grounding, everything else prioritization, design decisions, sequencing, even organizational alignment suddenly becomes much easier because you're no longer debating abstractions, you're working against the same measurable anchor. And the irony is, the faster you try to skip this step, the longer the project drags on, because every downstream conversation becomes a debate about interpretive language rather than a conversation about a shared, observable experience. __ Want people to pay for your product? Solve an *observable* problem—not a vague information or data problem. What do I mean? “When you're trying to solve a problem for users, especially in analytical or AI-driven products, one of the biggest traps is relying on interpretive statements instead of observable ones. Interpretive phrasing like ‘they're overwhelmed' or ‘they don't trust the data' feels descriptive, but it hides the important question of what, exactly, we can see them doing that signals the problem. If you can't film it happening, if you can't watch the behavior occur in real time, then you don't actually have a problem definition you can design around. Observable frustration might be the user jumping between four screens, copying and pasting the same value into different systems, or re-running a query five times because something feels off even though they can't articulate why. Those concrete behaviors are what allow teams to converge and say, ‘Yes, that's the thing, that is the friction we agree must change,' and that shift from interpretation to observation becomes the foundation for better design, better decision-making, and far less wasted effort. And once you anchor the conversation in visible behavior, you eliminate so many circular debates and give everyone, from engineering to leadership, a shared starting point that's grounded in reality instead of theory." __ One of the reasons that measuring the usability/utility/satisfaction of your product's UX might seem hard is that you don't have a baseline definition of how satisfactory (or not) the product is right now. As such, it's very hard to tell if you're just making product *changes*—or you're making *improvements* that might make the product worth paying for at all, worth paying more for, or easier to buy. "It's surprisingly common for teams to claim they're improving something when they've never taken the time to document what the current state even looks like. If you want to create a meaningful improvement, something a user actually feels, you need to understand the baseline level of friction they tolerate today, not what you imagine that friction might be. Establishing a baseline is not glamorous work, but it's the work that prevents you from building changes that make sense on paper but do nothing to the real flow of work. When you diagram the existing workflow, when you map the sequence of steps the user actually takes, the mismatches between your mental model and their lived experience become crystal clear, and the design direction becomes far less ambiguous. That act of grounding yourself in the current state allows every subsequent decision, prioritizing fixes, determining scope, measuring progress, to be aligned with reality rather than assumptions. And without that baseline, you risk designing solutions that float in conceptual space, disconnected from the very pains you claim to be addressing." __ Prototypes are a great way to learn—if you're actually treating them as a means to learn, and not a product you intend to deliver regardless of the feedback customers give you. "People often think prototyping is about validating whether their solution works, but the deeper purpose is to refine the problem itself. Once you put even a rough prototype in front of someone and watch what they do with it, you discover the edges of the problem more accurately than any conversation or meeting can reveal. Users will click in surprising places, ignore the part you thought mattered most, or reveal entirely different frictions just by trying to interact with the thing you placed in front of them. That process doesn't just improve the design, it improves the team's understanding of which parts of the problem are real and which parts were just guesses. Prototyping becomes a kind of externalization of assumptions, forcing you to confront whether you're solving the friction that actually holds back the flow of work or a friction you merely predicted. And every iteration becomes less about perfecting the interface and more about sharpening the clarity of the underlying problem, which is why the teams that prototype early tend to build faster, with better alignment, and far fewer detours." __ Most founders and data people tend to measure UX quality by “counting usage” of their solution. Tracking usage stats, analytics on sessions, etc. The problem with this is that it tells you nothing useful about whether people are satisfied (“meets spec”) or delighted (“a product they can't live without”). These are product metrics—but they don't reflect how people feel. There are better measurements to use for evaluating users' experience that go beyond “willingness to pay.” Payment is great, but in B2B products, buyers aren't always users—and we've all bought something based on the promise of what it would do for us, but the promise fell short. "In B2B analytics and AI products, the biggest challenge isn't complexity, it's ambiguity around what outcome the product is actually responsible for changing. Teams often define success in terms of internal goals like ‘adoption,' ‘usage,' or ‘efficiency,' but those metrics don't tell you what the user's experience is supposed to look like once the product is working well. A product tied to vague business outcomes tends to drift because no one agrees on what the improvement should feel like in the user's real workflow. What you want are visible, measurable, user-centric outcomes, outcomes that describe how the user's behavior or experience will change once the solution is in place, down to the concrete actions they'll no longer need to take. When you articulate outcomes at that level, it forces the entire organization to align around a shared target, reduces the scope bloat that normally plagues enterprise products, and gives you a way to evaluate whether you're actually removing friction rather than just adding more layers of tooling. And ironically, the clearer the user outcome is, the easier it becomes to achieve the business outcome, because the product is no longer floating in abstraction, it's anchored in the lived reality of the people who use it." Links Listen to part one: Episode 182 Schedule a Design-Eyes Assessment with me and get clarity, now.
In this episode of the Power Producers Podcast, host David Carothers and co-host Kyle Houck welcome back Brian Ahearn, Chief Influence Officer at Influence PEOPLE. They discuss his fifth book, Influence from Above, a business parable that merges Robert Cialdini's principles of persuasion with Biblical tenets. The conversation explores modern authorship using AI, the strict definition of ethical influence, and how to maintain relationships in a polarized world. Key Highlights: The Genesis of "Influence from Above" Brian Ahearn shares how a conversation with his daughter inspired him to map influence principles to Biblical concepts. The book serves as a sequel to The Influencer, following the main character as he applies these strategies within a church setting. Accelerating the Writing Process with AI David and Brian discuss leveraging technology in authorship. Brian details how he used ChatGPT as a real-time developmental editor—not to write the content, but to ensure character consistency and speed up editing, allowing him to finish the manuscript in just two months. Defining Ethical Influence Brian outlines his three-part framework to ensure influence never crosses into manipulation: 1) Be truthful, 2) Use natural principles (don't manufacture scarcity), and 3) Build relationships to leave people better off. Navigating Polarization and Relationships The group tackles the "cutoff culture" on social media. Brian explains how applying the principle of Liking and remaining genuinely curious about differing viewpoints allows him to maintain friendships despite opposing worldviews. Book Giveaway and Bonus Offer David announces a giveaway for the first 12 listeners to email him. Brian adds a bonus: buy the new book, email him the title of Chapter 2, and receive a digital copy of the prequel, The Influencer, for free. Connect with: David Carothers LinkedIn Brian Ahearn LinkedIn Kyle Houck LinkedIn Visit Websites: Power Producer Base Camp Influence PEOPLE, LLC Killing Commercial Crushing Content Power Producers Podcast Policytee The Dirty 130 The Extra 2 Minutes
Addressing the psychological side of workplace injuries can reduce recovery time by up to 70%, transforming outcomes for both workers and employers. In this episode, Joe Holtschlag, CEO of Ascellus Behavioral Health, and Liam Donohue, Founder and Managing Partner at .406 Ventures, explore how mental healthcare is transforming the workers' compensation system and why this evolving market brings both challenges and opportunities. Joe traces the system's evolution from its 1911 origins to today's inclusion of mental health injuries, noting that 31 states now allow standalone psychological claims. He explains how Ascellus coordinates clinicians, claims adjusters, and employers to build an infrastructure that prioritizes care while ensuring timely return-to-work outcomes, achieving 88% returns within 8–12 therapy sessions. Liam adds an investor's view, comparing this outcome-based model to AbleTo and emphasizing the double ROI of behavioral health, improving both human and financial results through technology, evidence-based therapy, and strategic partnerships. Tune in and learn how innovation and empathy are redefining recovery in the workplace! Resources: Connect with and follow Liam Donohue on LinkedIn. Learn more about .406 Ventures on LinkedIn and visit their website. Follow and connect with Joe Holtschlag on LinkedIn. Learn more about Ascellus Behavioral Health on LinkedIn and explore their website.
In this episode, we sit down with Solution Architect Robert Alvarez to discuss the technology behind Pure Key-Value Accelerator (KVA) and its role in accelerating AI inference. Pure KVA is a protocol-agnostic, key-value caching solution that, when combined with FlashBlade data storage, dramatically improves GPU efficiency and consistency in AI environments. Robert—whose background includes time as a Santa Clara University professor, NASA Solution Architect, and work at CERN—explains how this innovation is essential for serving an entire fleet of AI workloads, including modern agentic or chatbot interfaces. Robert dives into the massive growth of the AI Inference market, driven by the need for near real-time processing and low-latency AI applications. This trend makes the need for a solution like Pure KVA critical. He details how KVA removes the bottleneck of GPU memory and shares compelling benchmark results: up to twenty times faster inference with NFS and six times faster with S3, all over standard Ethernet. These performance gains are key to helping enterprises scale more efficiently and reduce overall GPU costs. Beyond the technical deep dive, the episode explores the origin of the KVA idea, the unique Pure IP that enables it, and future integrations like Dynamo and the partnership with Comet for LLM observability. In the popular “Hot Takes” segment, Robert offers his perspective on blind spots IT leaders might have in managing AI data and shares advice for his younger self on the future of the data management space. To learn more about Pure KVA, visit purestorage.com/launch. Check out the new Pure Storage digital customer community to join the conversation with peers and Pure experts: https://purecommunity.purestorage.com/ 00:00 Intro and Welcome 02:21 Background on Our Guest 06:57 Stat of the Episode on AI Inferencing Spend 09:10 Why AI Inference is Difficult at Scale 11:00 How KV Cache Acceleration Works 14:50 Key Partnerships Using KVA 20:28 Hot Takes Segment
What is helpful and what is hurtful in attracting new FDI to the US? Listen for more on Two Minutes in Trade.
What happens when innovation is shaping your life in ways you never see? That is the question at the heart of this conversation with Portia Lane Child, Director of Innovation and Strategy Services at BAE Systems. While most of us recognise the consumer brands that dominate our daily world, far fewer realise how deeply companies like BAE Systems influence the systems that keep us connected, protected, and moving. Portia's work lives in that fascinating space, where advanced engineering meets national mission, and where the innovations you never hear about are often the ones shaping your future. During our discussion, Portia shares how she helps steer innovation inside one of the world's most complex aerospace and defence organisations. She talks about the human side of innovating within a massive enterprise, the challenge of moving ideas across technical and organisational silos, and the lessons she learned growing up as a lobster fisherman's daughter that still guide how she builds teams and champions new ideas. Her story about creating an internal accelerator that changed how the business nurtures ideas is a powerful reminder that innovation only takes root when people feel supported to experiment, communicate, and stretch beyond familiar boundaries. We also explore the shifting incentives shaping today's innovators, from the pressure of short-term financial cycles to the growing importance of longer horizons in the age of AI. Portia opens up about what it really takes to move from idea to impact inside a mission-driven organisation, why customer conversations matter more than ever, and how modern innovators can develop the resilience and curiosity needed to operate in fast-moving technical environments. My guest also shares inspiring reflections on the inventions that shaped her, the role models who sparked her imagination, and the breakthroughs she believes the world needs most.
Most founders think VCs want a pitch deck full of market numbers, a roadmap, and a feel-good story about the future. Hoxton Ventures Partner Payton Dobbs isn't looking for any of that. He wants to know if you actually understand the game you're trying to play. In this conversation, Payton breaks down the tactical stuff founders almost always get wrong: why TAM slides don't matter how to define your real market what early signals prove you have a painkiller and not a vitamin and why most technical founders fail their first go-to-market quiz before the conversation even begins. He also talks about category creation, how to hire in the U.S. if you're coming from Europe, why pricing is a strategic weapon, and the number-one question he asks every founder — the one that quietly decides whether you're playing at venture scale or not. If you're an early-stage builder, this episode will help you level up before you start meeting with VCs. RUNTIME 1:00:46 EPISODE BREAKDOWN 02:12: Payton Dobbs' background and the value of building presence in key markets 03:25: Not all good ideas are venture scale: how to assess billion-dollar potential 04:01: Why new category creation is crucial for venture scale startups 06:35: What VCs look for in a pitch deck: TAM, SAM, and logic behind the numbers 08:06: Case study: Deliveroo and building new markets from small segments 09:07: Identifying pain points and leveraging founder expertise 10:57: Advice for technical founders: the value of complementary co-founders and commercial skills 12:23: Building frameworks: due diligence on markets, competitors, and learning from others' mistakes 13:54: Adapting go-to-market strategies for different business models (B2B SaaS, consumer, etc.) 15:00: The importance of having a perspective and being able to debate your point of view 15:50: Solo founders vs. teams: most are teams, but solo founders can succeed too 13:28: The state of the AI ecosystem in Europe and why it's accelerating 17:18: Navigating US immigration and talent: why keeping dev teams in Europe can be strategic 20:34: Common mistakes when entering the US: “If you build it, they will not come” 21:21: Do you need to reboot customer discovery in new markets? Sometimes, but not always 22:24: The importance of understanding the competitive landscape and customer needs in each market 24:54: Hiring in the US: cultural differences and what to look for in team members 27:33: Payton's parting advice for founders expanding to the US: grind, network, and be relentless 28:36: Building sales ops from scratch: tools, systems, and process before people 32:05: Understanding and accruing value in the business value chain 34:45: Signals that a team can move from tech to traction: agility, speed, and adaptability 36:37: Pricing as an art and a science; lessons from Nest and Apple 40:00: Metrics: NPS, customer surveys, and forward-looking indicators 44:42: What Payton hopes to unlock for founders by being based in the US LINKS Payton Dobbs Hoxton Ventures White paper: Europe's Sputnik Moment NVIDIA partnership: Accelerating the UK's AI Startup Ecosystem SUBSCRIBE
The Bitcoin Boomers Ep. 02: Fiat's Final Days & AI Job Apocalypse | Larry Lepard, Dr. Bob Murphy, Bob Burnett, Gary LelandDr. Bob Murphy (NYU PhD, Mises Institute Senior Fellow, former Contra Krugman host) joins Bob Burnett, Larry Lepard, and Gary Leland for the most explosive Bitcoin Boomers episode yet. From the very first minutes the gloves come off: fiat's 100-year Keynesian experiment is mathematically doomed, AI is already wiping out entry-level jobs overnight, robots are on track to rival nation-states, and deflationary technology just made debt-based money impossible to sustain. Larry drops the hammer (“the whole experiment is about to blow the fuck up — and it deserves to”), Bob Murphy calmly explains why Bitcoin proves you don't need the state to have money, and the crew debates UBI inevitability, spend-and-replace adoption strategies, and why BlackRock & nation-states are suddenly begging for Bitcoin.This is the red-pill episode you send to every boomer, uncle, or normie who still thinks the dollar is fine. If you want the intellectual ammo to orange-pill anyone over the holidays, this is it.Key Topics:Why fiat is now mathematically unsustainableAI silently killing entry-level hiring todayRobots rivaling nation-states in powerDeflationary tech destroying debt-based moneyBitcoin proves you don't need government to issue moneyThe regression theorem tragedy that cost Austrians millionsUBI is politically unstoppableGreenspan's private confession: being Fed Chair was “absolutely intoxicating”Spend-and-replace vs pure HODL debateBlackRock begging for Bitcoin — Bob's biggest 2025 shock20% Bitcoin discount at the CrossFit gym storyWhy the next 100 M users could arrive in monthsChapters:00:00:00 Cold Open – The end of fiat has begun00:01:11 Welcome Dr. Bob Murphy & Bob Burnett00:03:20 Why economics has warring schools00:12:17 MMT exposed00:19:16 Larry: “It's about to blow the fuck up — and it deserves to”00:26:26 AI already killing entry-level jobs00:33:46 UBI is coming — politically impossible to stop00:39:50 Robots will rival nation-states00:43:10 Deflation just killed debt-based money00:46:48 “Bitcoin proved you don't need the state to issue money”00:52:31 The regression theorem tragedy00:55:21 Spend-and-replace debate01:00:41 Real-world Bitcoin adoption stories01:04:38 BlackRock begging for Bitcoin01:10:57 “I cannot believe we got here this fast”Guest : Dr. Robert Murphy (@BobMurphyEcon) – NYU PhD, Mises Institute Senior Fellow, Chief Economist at InfinitoWebsite: https://www.bobmurphyshow.com/Hosts:Lawrence Lepard (@LawrenceLepard): Sound money advocate, fund manager, author of "The Big Print" Bob Burnett (@boomer_btc): Bitcoin evangelist, Founder/CEO of Barefoot Mining, former CTO at Gateway Inc. Board member at Ocean with over 40 years in tech and mining.Gary Leland (@GaryLeland): Founder of Bit Block Boom Bitcoin Conference.Supported By:Blockstream Jade: Easy, open-source Bitcoin-only cold storage. Get 10% off with code BOOMERS at blockstream.com.Unchained Signature: Premium custody for serious holders. 10% off first year with code BOOMERS10 at unchained.com/btcboomersAbundant Mines: Fully managed Bitcoin mining. Learn more at abundantmines.comBITCOIN WELL is the best place to buy Bitcoin in Canada and the USA.Visit BITCOINWELL.COM/BTCSESSIONSBook Private Sessions: Master Bitcoin with experts at bitcoinmentor.io. Check Out the Previous Episode w George Bodine: https://youtu.be/vO6J_JEDxKc#bitcoin #bitcoinboomers #fiatcollapse #bobmurphy #bobburnett #larrylepard #austrianeconomics #bitcoin2025 #ai #deflation #bitcoinadoption #soundmoney #btc
Thanks for listening to Episode #67 of the EDventUres in Tech Podcast. In this podcast episode, we are back and better than ever! Andrew & Dan are back with all the good tech news and updates and part two of our interview with Ditch That Textbooks Matt Miller! EDventUres in Tech WebsiteOnce again, thank you for all your support in listening on all platforms and leaving us a review. If you have any questions, comments, or suggestions, please reach out.Tech Hard again. Work smart. Live an EDventUre.
For access to Peter's publication:+ https://uncommonleadership.substack.com/p/the-pentagon-finally-killed-its-bureaucratic+ https://uncommonleadership.substack.com/p/why-the-speed-and-forged-acts-alone Hosted on Acast. See acast.com/privacy for more information.
This episode of the JofA podcast explores Accounting Opportunities Experience month, a growing nationwide program to inspire students to pursue accounting careers. Liz Burkhalter, the AICPA's vice president–CPA Pipeline, shares how CPAs and volunteers are working to reach 50,000 students through classroom visits and events. She also mentioned resources that can help listeners who want to volunteer. n Specific CPA Pipeline resources for student outreach n This Way To CPA home page n Burkhalter's June appearance on the JofA podcast n The Next Stop: CPA podcast Scott Spiegel, CPA/CITP, CGMA, the chief operating officer of the Association of International Certified Professional Accountants, discusses his return to Rutgers University and why real-world stories can expose students to the diverse opportunities in the profession. What you'll learn from this episode: The history and growth of Accounting Opportunities Experience month. Burkhalter's summary of participation numbers last year and goals for this year. Resources for accountants interested in speaking to students. Spiegel's motivation for making campus visits. The common questions and misconceptions he hears when talking to students. The importance of in-person outreach and storytelling.
The best biotech and pharmaceutical innovations mean nothing if they can't be protected—and protected fast. Our next guest, Josh Goldberg, is solving this challenge as co-managing partner at Nath, Goldberg & Meyer, the #1 ranked patent law firm for biotech and pharmaceutical technologies. With nearly three decades of IP law experience and a unique background as a lab researcher, Josh brings an insider's understanding of how innovation actually happens. He's helped industry leaders like Amgen, Takeda, and GlaxoSmithKline turn breakthrough treatments into patent-protected portfolios—often in under a year instead of the typical four-year timeline. Driven by a passion for focus and strategic IP timing, Josh shares his pioneering approach to biotech and pharmaceutical patent prosecution. Join us to discover how smart IP strategy drives licensing power, regulatory success, and company valuation. Let's go!Episode Highlights:Focus drives success – Companies fail by trying to do everything at once; staying deliberate and focused is key to making real impactOne-year patent timelines vs. four years – Josh uses USPTO's Track 1 program to secure patents in record time, improving fundraising and M&A positioningClient-centered approach wins – Listening to unique client needs instead of one-size-fits-all strategies earned the firm its #1 rankingDiagnostic patents are back – New USPTO Director signals the patent office is "open for business" again after a decade of restrictionsScientist turned patent attorney – Josh's lab background gives him insider understanding of how innovation actually happensAbout our Guest: Joshua is the patent attorney innovation-driven pharmaceutical companies call when they need to turn complicated technologies into protected assets in record time.As co-managing partner at Nath, Goldberg & Meyer—the #1 ranked patent law firm for biotech and pharmaceutical technologies in both 2024 and 2025—Joshua leads IP efforts across industries like biotech, pharma, agriculture, renewable energy, and advanced materials. Whether it's a blockbuster acne treatment like DUAC, a vitamin D analog lotion like Sorilux, OTC solutions like Salonpas and Germagic, or a leading drug used to reduce stomach acid and treat conditions like GERD, ulcers, and heartburn—like Protonix—Joshua helps turn high-stakes R&D into patent-protected portfolios, often in under a year instead of the typical four-year timeline.Though his climate and agricultre IP expertise has made him famous as the “green patent guy,” Joshua moves between disciplines skillfully and has helped industry leaders like Amgen, Takeda, Guilford Pharmaceuticals, Mayne, and Stiefel Laboratories (which was acquired by GlaxoSmithKline) build pharma portfolios that hold up under investor, acquirer, and FDA scrutiny.His journey didn't begin in IP law, but in the lab, researching experimental pharmaceutical delivery systems. It gave him an edge most attorneys don't have: understanding how innovation actually happens, and how to protect it without slowing a business down. Links Supporting This Episode: Nath, Goldberg & Meyer Website: CLICK HEREJoshua Goldberg LinkedIn page: CLICK HERENath, Goldberg & Meyer LinkedIn: CLICK HEREMike Biselli LinkedIn page: CLICK HEREMike Biselli Twitter page:...
Mike Pell is an author, an artist and the director of the Microsoft Garage, the worldwide innovation program where he applies “fast design” principles to bring ideas to prototypes quickly. Mike's hackathons scale to include 10,000 participants. Mike tells the Futurists how artificial intelligence systems accelerate ideation during the innovation process. The challenge: managing a team of AI agents will require human workers to adapt to entirely new processes and discard some outdated practices. Visualization is one of the key elements in Mike's approach to this process, as conveyed in his recent book, “Visualizing Business”.
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Today I'm joined by Alan Haig, President of Haig Partners. We dig into why Q4 buy-sell activity is suddenly exploding, which franchises are becoming “must-own” (and which aren't), how rate cuts are reshaping buyer math, and get a sneak peek at the latest Haig Report before its released. This episode is brought to you by: 1. Equifax - Fund More Auto Loans, Faster. Auto loan applicants are 40% more likely to be funded when instantly verified by The Work Number. You can get the data you need to know your borrower better and make fast, smart decisions. Equifax provides instant, secure access to verified borrower identity, address, income, and employment information, helping you move deals forward quickly." Visit @ https://carguymedia.com/3Lplzue to learn more. 2. Amazon Auto - With Amazon Autos, your dealership can reach more buyers, drive more sales, and deliver a modern, more delightful car-buying experience. Learn more @ https://sell.amazon.com/programs/autos 3. Haig Partners - Since 2014, the Haig Report® has delivered expert analysis on dealership performance, market activity, and franchise valuations, offering a clear view of opportunities and challenges in automotive retail. Learn more in the full Q3 2025 Haig Report® by subscribing to receive it as soon as it's released. Visit @ https://share.hsforms.com/1AEDx2iJDSsibryqbI1HyCgnr2vn 4. CDG Circles - A modern peer group for auto dealers. Private dealer chats. Real insights — confidential, compliant, no travel required. Visit https://cdgcircles.com to learn more. Check out Car Dealership Guy's stuff: For dealers: Industry job board ➤ http://jobs.dealershipguy.com Dealership recruiting ➤ http://www.cdgrecruiting.com Fix your dealership's social media ➤ http://www.trynomad.co Request to be a podcast guest ➤ http://www.cdgguest.com For industry vendors: Advertise with Car Dealership Guy ➤ http://www.cdgpartner.com Industry job board ➤ http://jobs.dealershipguy.com Request to be a podcast guest ➤ http://www.cdgguest.com Topics: 00:59 What defines the marathon's spirit? 02:53 Why did the CarMax CEO resign? 03:49 How is Carvana influencing the market? 07:14 Current state of the auto market? 11:14 Which brands are performing best? 21:40 Who is buying cars today? 26:51 Biggest opportunity in dealership sales? 29:05 Where are the hottest regional markets? 43:59 Future outlook for dealers? Car Dealership Guy Socials: X ➤ x.com/GuyDealership Instagram ➤ instagram.com/cardealershipguy/ TikTok ➤ tiktok.com/@guydealership LinkedIn ➤ linkedin.com/company/cardealershipguy Threads ➤ threads.net/@cardealershipguy Facebook ➤ facebook.com/profile.php?id=100077402857683 Everything else ➤ dealershipguy.com
Biotech Bytes: Conversations with Biotechnology / Pharmaceutical IT Leaders
AI in Drug Discovery | #aidrugdiscovery #biotechinnovation #medicalinnovationAmid a rapidly changing biotech landscape, AI is transforming how we discover and develop new medicines. Please visit our website to get more information: https://swangroup.net/ In this episode, I sit down with Smbat Rafayelyan, founder and CEO of Bioneex, a platform that connects early-stage biotech innovators with investors and pharma companies using AI-driven insights. He shares his journey from big pharma to entrepreneurship and how his team is reshaping drug discovery.We explore how personalized large language models are being applied in biotech, the role of data integration in connecting biotech, pharma, and investors, and why China's biotech ecosystem is fueling a surge of innovation.✅ How personalized AI models improve drug discovery and evaluation✅ The role of data integration in connecting biotech, pharma, and investors✅ Global opportunities, including China's emerging biotech sectorIf you've ever wondered how AI is making sense of scientific data chaos, this episode is a must-watch.Links from this episode:✅ Get to know more about Smbat Rafayelyan: https://www.linkedin.com/in/dr-smbat-rafayelyan/?originalSubdomain=de ✅ Learn more about Bioneex: https://bioneex.com
Down, but not out. American democracy in the 21st century.----------Marci Shore is an American professor at the Monk School Munk School of Global Affairs and previously professor of intellectual history at Yale University, where she specializes in the history of literary and political engagement with Marxism and phenomenology. Marci is author of Caviar and Ashes: A Warsaw Generation's Life and Death in Marxism, 1918–1968, and of The Taste of Ashes, a study of the presence of the communist and Nazi past in today's Eastern Europe. But today we will be discussing her most recent book, about the Revolution of Dignity – The Ukrainian Night: An Intimate History of Revolution. ----------LINKS:https://twitter.com/marci_shorehttps://en.wikipedia.org/wiki/Marci_Shorehttps://jackson.yale.edu/person/marci-shore/https://history.yale.edu/people/marci-shorehttps://yalebooks.co.uk/book/9780300276831/the-ukrainian-night/https://www.ukrainianworldcongress.org/marci-shore-on-revolution-of-dignity/----------BOOKS:The Taste of AshesThe Ukrainian Night: An Intimate History of Revolution----------SILICON CURTAIN FILM FUNDRAISERA project to make a documentary film in Ukraine, to raise awareness of Ukraine's struggle and in supporting a team running aid convoys to Ukraine's frontline towns.https://buymeacoffee.com/siliconcurtain/extrashttps://www.patreon.com/siliconcurtain/collections----------SILICON CURTAIN LIVE EVENTS - FUNDRAISER CAMPAIGN Events in 2025 - Advocacy for a Ukrainian victory with Silicon Curtainhttps://buymeacoffee.com/siliconcurtain/extrasOur events of the first half of the year in Lviv, Kyiv and Odesa were a huge success. Now we need to maintain this momentum, and change the tide towards a Ukrainian victory. The Silicon Curtain Roadshow is an ambitious campaign to run a minimum of 12 events in 2025, and potentially many more. Any support you can provide for the fundraising campaign would be gratefully appreciated. https://buymeacoffee.com/siliconcurtain/extrasWe need to scale up our support for Ukraine, and these events are designed to have a major impact. Your support in making it happen is greatly appreciated. All events will be recorded professionally and published for free on the Silicon Curtain channel. Where possible, we will also live-stream events.https://buymeacoffee.com/siliconcurtain/extras----------SUPPORT THE CHANNEL:https://www.buymeacoffee.com/siliconcurtainhttps://www.patreon.com/siliconcurtain----------DESCRIPTION:The Dangers of Authoritarianism: In-Depth with Marcy ShawIn this compelling episode, Jonathan welcomes Marcy Shaw, a historian specializing in Marxism and phenomenology, to discuss the ongoing struggle in Ukraine and its implications. The conversation unveils crucial insights into the brutal realities of the Ukrainian conflict and the strategic manipulation by Russia under Putin. They explore the normalization of politics in abnormal times and the unsettling parallels between historical tyrannies and current authoritarian regimes. The discussion expands to the broader context of authoritarian tendencies, including those in the United States, revealing a worrying drift towards impunity, ritual humiliation, and performative sadism. The episode ends on a thought-provoking note, setting the stage for future discussions on resisting authoritarianism.----------TRUSTED CHARITIES ON THE GROUND:kharpp - Reconstruction project supporting communities in Kharkiv and Przemyślhttps://kharpp.com/Save Ukrainehttps://www.saveukraineua.org/Superhumans - Hospital for war traumashttps://superhumans.com/en/UNBROKEN - Treatment. Prosthesis. Rehabilitation for Ukrainians in Ukrainehttps://unbroken.org.ua/Come Back Alivehttps://savelife.in.ua/en/Chefs For Ukraine - World Central Kitchenhttps://wck.org/relief/activation-chefs-for-ukraineUNITED24 - An initiative of President Zelenskyyhttps://u24.gov.ua/----------
In this episode of our AI-enabled e-discovery series, host Anthony Diana sits down with Reed Smith's Marcin Krieger and Gravity Stack's Sharri Wilner to unpack Relativity aiR: Relativity's embedded generative AI framework for e-discovery. The conversation breaks down how aiR differs from traditional TAR/CAL, what it means to treat prompts as a “review protocol,” and where it delivers outsized value today. The team explores aiR's two core applications: aiR for Review to accelerate responsiveness and issue coding across large data sets, and aiR for Case Strategy to summarize transcripts, surface themes, and drive smarter deposition prep. The team also discusses validation, defensibility, and emerging tools such as Air Assist, offering practical tips for managing risk, change, and ethics as GenAI becomes part of daily practice.
This is the latest episode of the free DDW Narrated Podcast, called "How new scientific approaches are accelerating R&D". The episode covers two articles written for DDW Volume 25, Issue 1, Winter 2023/24. The first article is called 'Accelerating recombinant protein vaccine discovery'. In the article, Jian He, Chemistry, Manufacturing and Controls (CMC) Head at WuXi Vaccines, explains why vaccination responses need to be rapid, efficacious and cost-effective if they are to outpace new viral threats emerging across the globe. The second article is called 'How 3D biology is informing drug discovery'. In the piece, DDW Editor Reece Armstrong looks at the advantages and opportunities 3D cell cultures, organoids and stem cells are bringing to drug discovery teams. You can listen below, or find The Drug Discovery World Podcast on Spotify, Google Play and Apple Podcasts.
#383 In this enlightening podcast episode, Guy welcomed Mark Patterson, a returning guest with an extraordinary story. Mark delved into his near-death experience at age 16, where he encountered divine beings and received profound insights into sacred geometry and healing through sound frequencies. The conversation also explored the current spiritual awakening happening on the planet, enhanced by celestial events like the 3I Atlas comet. Mark discussed how humanity's evolution is intertwined with these cosmic occurrences and emphasizes the importance of self-belief and personal empowerment. Additionally, Mark introduced his upcoming platform 'Voices of Light: Empowering the Empath,' aimed at providing a safe space for psychics, intuitives, and empaths to share their stories and gifts. Tune in to discover more about aligning with higher frequencies, the significance of sacred geometry, and the transformative potential of embracing one's inner light. About Mark: Mark Patterson is an internationally recognized Expert on sound healing. He has received praise from numerous best-selling authors for his uncanny abilities with sound healing and vocal toning. Mark was given the ability to heal others through sound in a Near Death Experience. He has been a keynote speaker at expos and conferences all over the world. He has been featured on countless podcasts on his NDE. Over 1M people have viewed his NDE story. He currently resides in the Asheville, NC area. Key Points Discussed: (00:00) - Galactic Downloads & The Hidden Codes Accelerating Human Evolution! (00:55) - Host's Personal Update (01:46) - Guest Introduction and Podcast Setup (03:58) - Mark's Near-Death Experience (05:41) - The Grand Solar Flare Theory (09:01) - The Doomsday Comet and Energetic Codes (15:44) - ET Contact and Sacred Geometry (21:17) - Mark's Early Spiritual Experiences (25:59) - Near-Death Experience and Aftermath (36:42) - Introduction to Jerry Bowman and Joel Biani (37:33) - Teachings of John the Apostle (41:55) - Encounter with Roger and the Flower of Life (47:13) - A Mysterious Call and a New Path (57:46) - Voices of Light: Empowering the Empath (01:02:39) - Final Thoughts and Encouragement How to Contact Mark Patterson:mark-patterson.com About me:My Instagram: www.instagram.com/guyhlawrence/?hl=en Guy's websites:www.guylawrence.com.au www.liveinflow.co
This episode features a deep dive into Occidental Petroleum's cloud migration journey, emphasizing automation and scalability. Brian Moore, a Cloud Architect at Occidental Petroleum, discusses how they used Terraform and AFT to streamline account provisioning, manage complex network architectures, and improve operational efficiency. The conversation reveals lessons on organizational change, the importance of source-controlled infrastructure, and how automation tools like Terraform and Control Tower can transform traditional IT workflows into agile, resilient systems.
Building B2B analytics and AI tools that people will actually pay for and use is hard. The reality is, your product won't deliver ROI if no one's using it. That's why first principles thinking says you have to solve the usage problem first. In this episode, I'll explain why the key to user adoption is designing with the flow of work—building your solution around the natural workflows of your users to minimize the behavior changes you're asking them to make. When users clearly see the value in your product, it becomes easier to sell and removes many product-related blockers along the way. We'll explore how product design impacts sales, the difference between buyers and users in enterprise contexts, and why challenging the “data/AI-first” mindset is essential. I'll also share practical ways to align features with user needs, reduce friction, and drive long-term adoption and impact. If you're ready to move beyond the dashboard and start building products that truly fit the way people work, this episode is for you. Highlights/Skip to: The core argument: why solving for user adoption first helps demonstrate ROI and facilitate sales in B2B analytics and AI products (1:34) How showing the value to actual end users—not just buyers—makes it easier to sell your product (2:33) Why designing for outcomes instead of outputs (dashboards, etc) leads to better adoption and long-term product value (8:16) How to “see” beyond users' surface-level feature requests and solutions so you can solve for the actual, unspoken need—leading to an indispensable product (10:23) Reframing feature requests as design-actionable problems (12:07) Solving for unspoken needs vs. customer-requested features and functions (15:51) Why “disruption” is the wrong approach for product development (21:19) Quotes: “Customers' tolerance for poorly designed B2B software has decreased significantly over the last decade. People now expect enterprise tools to function as smoothly and intuitively as the consumer apps they use every day. Clunky software that slows down workflows is no longer acceptable, regardless of the data it provides. If your product frustrates users or requires extra effort to achieve results, adoption will suffer. Even the most powerful AI or analytics engine cannot compensate for a confusing or poorly structured interface. Enterprises now demand experiences that are seamless, efficient, and aligned with real workflows. This shift means that product design is no longer a secondary consideration; it is critical to commercial success. Founders and product leaders must prioritize usability, clarity, and delight in every interaction. Software that is difficult to use increases the risk of churn, lengthens sales cycles, and diminishes perceived value. Products must anticipate user needs and deliver solutions that integrate naturally into existing workflows. The companies that succeed are the ones that treat user experience as a strategic differentiator. Ignoring this trend creates friction, frustration, and missed opportunities for adoption and revenue growth. Design quality is now inseparable from product value and market competitiveness. The message is clear: if you want your product to be adopted, retain customers, and win in the market, UX must be central to your strategy.” — “No user really wants to ‘check a dashboard' or use a feature for its own sake. Dashboards, charts, and tables are outputs, not solutions. What users care about is completing their tasks, solving their problems, and achieving meaningful results. Designing around workflows rather than features ensures your product is indispensable. A workflow-first approach maps your solution to the actual tasks users perform in the real world. When we understand the jobs users need to accomplish, we can build products that deliver real value and remove friction. Focusing solely on features or data can create bloated products that users ignore or struggle to use. Outputs are meaningless if they do not fit into the context of a user's work. The key is to translate user needs into actionable workflows and design every element to support those flows. This approach reduces cognitive load, improves adoption, and ensures the product's ROI is realized. It also allows you to anticipate challenges and design solutions that make workflows smoother, faster, and more efficient. By centering design on actual tasks rather than arbitrary metrics, your product becomes a tool users can't imagine living without. Workflow-focused design directly ties to measurable outcomes for both end users and buyers. It shifts the conversation from features to value, making adoption, satisfaction, and revenue more predictable.” — “Just because a product is built with AI or powerful data capabilities doesn't mean anyone will adopt it. Long-term value comes from designing solutions that users cannot live without. It's about creating experiences that take people from frustration to satisfaction to delight. Products must fit into users' natural workflows and improve their performance, efficiency, and outcomes. Buyers' perceived ROI is closely tied to meaningful adoption by end users. If users struggle, churn rises, and financial impact is diminished, regardless of technical sophistication. Designing for delight ensures that the product becomes a positive force in the user's daily work. It strengthens engagement, reduces friction, and builds customer loyalty. High-quality UX allows the product to demonstrate value automatically, without constant explanations or hand-holding. Delightful experiences encourage advocacy, referrals, and easier future sales. The real power of design lies in aligning technical capabilities with human behavior and workflow. When done correctly, this approach transforms a tool into an indispensable part of the user's job and a demonstrable asset for the business. Focusing on usability, satisfaction, and delight creates long-term adoption and retention, which is the ultimate measure of product success.” — “Your product should enter the user's work stream like a raft on a river, moving in the same direction as their workflow. Users should not have to fight the current or stop their flow to use your tool. Introducing friction or requiring users to change their behavior increases risk, even if the product delivers ROI. The more naturally your product aligns with existing workflows, the easier it is to adopt and the more likely it is to be retained. Products that feel intuitive and effortless become indispensable, reducing conversations about usability during demos. By matching the flow of work, your solution improves satisfaction, accelerates adoption, and enhances perceived value. Disrupting workflows without careful observation can create new problems, frustrate users, and slow down sales. The goal is to move users from frustration to satisfaction to delight, all while achieving the intended outcomes. Designing with the flow of work ensures that every feature, interface element, and interaction fits seamlessly into the tasks users already perform. It allows users to focus on value instead of figuring out how to use the product. This alignment is key to unlocking adoption, retaining customers, and building long-term loyalty. Products that resist the natural workflow may demonstrate ROI on paper but fail in practice due to friction and low engagement. Success requires designing a product that supports the user's journey downstream without interruption or extra effort. When you achieve this, adoption becomes easier, sales conversations smoother, and long-term retention higher.” —
Why does it take ten years to bring a new medicine to market, and how can we reduce that number? In this episode of Talking Digital Industries, host Alex Chavez dives into the future of pharma and life sciences with Siobhan Fleming, Solution Owner for Digital Lab at Siemens; Andy Whytock, Pharma Expert at Siemens; and Sean Ruane, Principal Data Scientist at the Medicines Manufacturing Innovation Center. Discover how Siemens' Enterprise Recipe Management and AI-driven lab technologies are helping reduce development timelines, improve sustainability, and, in this case, to bring life-saving treatments to patients faster with the Digital Twin and AI.
Ed, Simon and Harvey discuss the restructuring of SeLoger in France, the potential sale of Yad2 by Aviv Group, the cancellation of Dubizzle Group's IPO, and financial highlights from major marketplaces like Scout24. The conversation also highlights emerging trends in product innovation, particularly the rise of AI search functionalities in real estate portals.
An Angel For Bishop: Part 1 When two damaged souls collide can they find salvation. In 4 parts, based on a post by BurntRedstone. Listen to the Podcast at Steamy Stories. Wednesday night before Thanksgiving, 2010 Chapter 1 The early winter storm raged and thrashed across the mountain range. It seemed especially angry with the narrow mountainside road Dan was cautiously driving his jeep on. The fierce winds fought to push the jeep across the icy road into the deep ravine below. If it wasn't for the heavy tire chains he'd installed at the base of the mountain he'd already be tumbling down that cliff. He hadn't intended on being away from his cabin at all before the winter storms arrived. He'd discovered that some of his med kit supplies had expired and needed replacing before he was snowed in for the season. It was definitely a bad idea to skimp on medical supplies when you had no access to a hospital, or doctors, for up to four months. And since he was in town anyway he'd decided to stock up on extra food as, you know, no grocery stores in his neighborhood. With the sudden arrival of what was turning out to be a monster storm he was in danger of not making it back to his neighborhood at all. He knew the road behind him was empty of cars as he'd been the last one through before the highway patrol closed the gates to the mountain road. By now the road behind would be completely impassable so there was no going back. Not that he intended to. Not when he was almost at his turn off. From the curving mountain road he'd be turning uphill, driving up a rough fire road for two miles then into an even more rugged trail for another mile through the forest to his house. If the storm picked up any more even his customized jeep with its extra clearance wouldn't make it beyond the highway and he'd have to snowshoe in the remaining distance. That was not something he was looking forward to. Dan's jeep ground its way along the snowy road getting closer and closer to the fire road. A short time later he rounded the last bend and spotted the road marker indicating his turn was just ahead. On his right side was a thin strip of trees and beyond that nothing but sky. It was a scary section of road with minimal guard rails. It paid to take extra care here. He almost missed spotting the body in the tree as he drove past. Dan's subconscious mind latched onto the image and his foot was pressing carefully on the brake before his conscious mind knew why. Once he stopped he looked back over his shoulder to confirm what he'd seen. It wasn't just an odd shadow or a clump of branches. He could clearly see a body leaning into the branches of one of the trees dangling over the edge of the cliff. He put the jeep in park with the engine still running, set the hazards on, and cranked the heat up to full. He pulled his hood up and gloves on before he stepped out of the warm cabin of his jeep into the wailing storm. He made his way to the back of the jeep and looked again at where the body was in the tree. He'd have to climb up to get it and that was going to be risky. He pulled his climbing rope out of the back hatch of the jeep and stepped into the harness. Once secured, he tied the end of the rope to the trailer hitch and quickly made his way over to the side of the road. He could see the short section of guard rail had been slammed into, bent over, and broken off. It rested precariously on the edge. There was very little evidence of skid marks as the snow was blowing very hard by this point. He cautiously stepped forward and looked over the edge. Not too far below, maybe 50 feet, he saw the remains of one of those trike motorcycles. What kind of moron would be driving a motorcycle this late in the season? Just to the left of the wrecked bike and sprawled across a broken spruce tree stretching out over the abyss was the moron. Dan could see his legs were bent at an unnatural angle. Hell, his torso was bent wrong as well. Most likely his back was broken. The blizzard was making it very difficult to see the man clearly but he thought he could make out some kind of emblem on the ripped leather jacket. It could be a Blood Brothers jacket but he wasn't sure. Christ, he hoped not. If he was from that gang he was a LONG way from home. Dan called out to see if the man was still alive but either the storm was whipping the sound of his voice away or the man was dead. He looked up at the body in the tree and realized the helmet had moved to look in his direction so this one was definitely still alive. From here he couldn't tell if it was a slim man or a woman. The baggy leathers made it impossible to tell accurately. He took a few more steps towards the tree and saw its roots were deeply entangled with the rough cliff side. He judged it to be sturdy enough to support his weight if he climbed up. Just as he prepared to step off onto the tree he heard the unmistakable sound of a gunshot followed by a feminine cry. He looked up and saw the right sleeve of the leather jacket was torn and there was blood dripping from it. Dan looked down and saw the man below was holding a gun and was struggling to hold it steady. When he saw it swing towards him he flung himself back from the edge. A second shot rang out digging through the ground where he'd just stood. "What the fuck are you doing?!?" Dan yelled over the edge. "I'm here to rescue you!" "The bitch is mine! She dies with ME!" he heard the man reply. Another shot was fired but this one hit a branch to the woman's left. The man was deranged! Dan wouldn't be able to get to her before the maniac below hit something vital. And if Dan tried to climb out there he would likely be the target of the next bullet. He'd taken enough bullets in his life. He had to stop him. Quick! He frantically looked around for a weapon, something he could use to stop the idiot with the gun. Another shot rang out and the woman's helmet snapped to the side as the bullet grazed it. The only thing Dan saw was the broken section of guard rail. He reached down and with a huge effort lifted it above his head. It was damn heavy as chunks of two posts were still attached. Dan shuffled to the cliff's edge just above where the man was. He heaved the metal beam and lumber over the edge and watched as it fell. The man squealed in terror as the plummeting chunk of steel and lumber rushed down to crash into his broken body. It tore him and most of the spruce tree from the cliff face and they all fell hundreds of feet onto the rocks below. The crushed trike, which had been braced by the tree, slowly slid off the small ledge and tumbled after its owner. Dan quickly stepped out onto the tree and climbed up to the woman. He called out but she was limp and leaning into the tree. He saw that one of the branches had pierced her shoulder, pinning her in place. It probably saved her from falling to her death. The branch hadn't gone all the way through. He strapped her to his harness then he gently pulled her loose from the branch. Luck was on her side again. There was very little blood so nothing major had been hit by the branch. She was unexpectedly light. Dan got a good grip then descended the tree with her and pulled her backwards onto the road. Once safely away from the cliff he untied her and removed his harness. He scooped her up and carried her to the passenger side of the jeep. Once the door was open he slid her limp body onto the seat and pushed the seat back into its reclined position. Closing the door he raced around the back of the jeep, dropped the rope and harness through the hatch and got back into the driver's side. His face stung from the interior heat but after a few seconds it started to feel really good. Dan reached into the back seat and grabbed one of the new packages of bandage wrap. He used his belt knife to open the package and cut a section off. He did a quick field dressing on both her arm and the puncture wound on her shoulder. He reached under her helmet and pressed his fingers to her neck. Her pulse was a little weak but it seemed steady. Her skin was so cold! Looking at the bandages he realized it was all he could do for now. He really had to get her back to his house if he was going to save her from freezing to death. Slipping back into gear Dan rolled the jeep forward out of the snow pile that had accumulated around the vehicle. Soon he was moving steadily forward and he could see the fire road just ahead. The trees sheltered it better than the open highway but there was still a fair amount of snow to drive through. Dan turned into the road and maintained a steady pace as the road climbed ever upwards. The jeep was really struggling in the drifts as he rolled over the final crest before the forest trail. He quickly glanced at his passenger then swung the jeep into the trail and surged forward. The going was especially tough here but the chains continued to grip and dig into the hard ground beneath the snow. Occasionally he had to fight the wheel as the jeep slipped sideways, threatening to pin itself between the trees. Somehow he kept the momentum going until the jeep suddenly left the forest and he faced his garage door fifty feet ahead. Dan pushed the button on the remote strapped to his visor and saw the garage door begin to climb. He rolled the jeep forward slowly until it settled on the pad inside the garage. He pressed the remote button again and the door closed behind the jeep. He rushed over to the inside door and propped it open. He went back to the passenger side, opened the door and carefully lifted the woman's body out of the jeep, keeping her helmeted head against his shoulder. He couldn't get over how light she was. She had to be at least as tall as him but she felt like nothing in his arms. As quickly and carefully as he could he carried her into the house and into the first guest bedroom. He set her on the bed and began to remove her damp clothing. The boots were first then her damp socks. The skin on her toes was the lightest shade of pink so it didn't look like she had frostbite there. The leather chaps came off fairly easily but her jeans were very damp. He unbuttoned them and slipped the zipper down. They weren't very tight but that was mostly due to how much weight she seemed to have lost. The skin on her legs almost seemed loose. She wasn't wearing panties and it looked like she kept herself completely shaved down below. A flash of gold drew his eyes to a single ring piercing her clitoral hood. He looked away, embarrassed. He dried off her legs with a thick towel he grabbed from the room's bathroom. He removed the chin strap and slid the helmet slowly and carefully upwards until he could toss it aside. Long but dull and matted platinum blond hair poured out of the helmet. It felt a bit like dry straw. He pushed it away from her face and sucked in a breath. She was exquisite! Almond shaped eyes (bruised looking and still closed), fine brows, high cheekbones, slender nose, and full, lush lips which currently looked dry and chapped. She was a true beauty, or would be if she could add on some healthy weight. Her cheeks were a little sunken. While he wanted to take a closer look at his patient he still had to remove her damp jacket and shirt. Both came off relatively easily and again Dan could see the woman was badly underfed. She wore no bra underneath her shirt and considering her obvious and rather large breast implants he was more than a little surprised by this. Those breasts had to be uncomfortable without some support. He saw more piercings, both of her nipples had small gold bars with loops. Dan dried her torso and arms with the towel then wrapped her in a thick, soft electric blanket from the room's closet and set it to a medium-high setting. He ran back to the jeep and grabbed the medical supplies he'd bought. He closed the garage door and went back to the woman. Opening the blanket to get access to her wounds he cleaned them and replaced her bandages. Aside from the grazed arm and the puncture on her shoulder there weren't any other fresh injuries he could see. Healed or healing ones though, she had plenty of scars to prove she'd born quite a lot of pain in her life. Some looked like burn marks, like someone had used her arm as an ashtray. He'd done what he could for now. He closed up the blanket and pulled the bed's quilt over her as well. Her pulse had steadied and seemed strong to him. He'd just have to wait for her to wake up so he could question her about where she might be feeling pain. He felt totally inadequate for the task of being her doctor but he was all she had as the storm continued to rage outside and showed no signs of lessening. He went back to the jeep and unloaded the food. He put most of it into the huge pantry in the kitchen but the meat went into the deep freezer in the garage. Back in the small bathroom of the guest bedroom he poured a glass of water and put it on the end table next to the bed. It was likely she'd be thirsty when she woke up. A quick look at the clock on the wall showed him it was past dinner time but he was more tired than hungry. The window in the room showed the sun must have set as all he could see was the snow that blew against the glass and blackness beyond. He sat in the room's only chair to keep vigil over his patient but shortly exhaustion pulled him down into its embrace and he was gone. Chapter 2 Bullets whizzed by his head, one taking a nip of his ear as it passed. Still he ran on. He had to get back to the house. He could hear the steady beat of the approaching copter's blades as he ran from cover to cover, popping up to fire a round through the head of the next unlucky bastard to get between him and the house. He felt the sting of a bullet passing through his calf but he put that sensation aside and continued on. He slammed into the front door of the house only this time it was locked and he had no way in. Dan gasped awake, the nightmare still raw in his mind. He could feel the familiar ache in his right calf. He leaned forward and put his head in his hands. His forehead was dripping wet. He shuddered as the reaction left his body. It was obvious to him what had triggered him this time. He hadn't been shot at in years but you never forget. Pulling his hands down he noticed the room around him. He glanced at the clock and was startled to see that he'd slept through the night. It was almost 7am. Then he felt eyes on him. Right! The woman! He looked over at her and saw she was awake and staring in his direction from behind her bangs, her gaze dull. The bed's quilt had been thrown back but she was still cocooned within the electric blanket. She had it wrapped around her head and all the way down and over her feet. Only her face showed. He stepped to the side of the bed and knelt down so he wasn't towering over her. Her eyes remained downcast, pointing somewhere in the general vicinity of his chest. He tried to get her to look into his eyes but she seemed to be avoiding this. He didn't quite know what to make of this behavior. "Hi, my name's Dan. Dan Bishop. You were in an accident out there on the mountain road. I found you and brought you to my home because the road back to town was closed by snow." He saw no response. "Can you hear me?" She nodded almost imperceptibly. "Can you tell me your name?" Nothing. "I need you to wiggle your toes." He saw a slight motion at the bottom of the blanket. "Good! How about your fingers?" The sides of the blanket moved a little as she moved her fingers. "That's excellent! Can you tell me where you might be feeling pain?" Nothing. Dan was feeling desperately out of his element. She could obviously understand what he was saying but she couldn't or wouldn't talk. Maybe she was frightened or embarrassed. I mean, she was in a strange place and a stranger had obviously removed her clothes. God! He was suddenly so embarrassed himself! While he knew it had been necessary he was still a little ashamed for having undressed her when she was unconscious. "Look, I'm terribly sorry for removing your clothes but they were wet and you were freezing to death. I'll get you something warm to wear." Dan suddenly realized there probably wasn't any woman's clothing in his house. He walked over to the dresser and checked in a few of the drawers. Nothing. "Uh, I might have something in the other rooms. I'll be right back." He rushed through the other guest rooms and again found nothing except a skimpy white bikini bathing suit. Last summer his buddy Wally visited with his latest girlfriend and she must have left it behind. She'd been petite and her tits had been much smaller than this woman's but he thought the swimsuit might be a good substitute for underwear at least. He went into his room and gathered up a flannel shirt, a thick sweater, some fleece sweat pants which had a drawstring, and a pair of warm socks. When Dan returned to the woman she hadn't moved but her eyes tracked him when he entered. "I have some clothes for you. Sorry, I don't have any woman's clothing but you can wear this stuff to keep warm until I've washed and dried the clothes you were wearing. I found a bathing suit you can use as underwear, if you want." She said nothing but continued to keep him in her view. He knelt once more beside the bed. "Can you tell me your name?" he asked gently but still got no response from the woman. "I'd feel more comfortable using a name than just saying 'Hey You'." He caught the flick of her eyes up to his face then to the doorway then back down to his chest. Was she expecting the man she was riding with to show up? Considering the scars he'd seen on her, it might explain some of her current behavior. If the asshole with the gun had been one of the Blood Brothers he'd probably treated her poorly. She seemed too frightened to talk. He rubbed his face and decided there wasn't going to be a better time to tell her. He wondered how much she recalled of her 'rescue'. That might be a good place to start. "Do you remember the accident?" he asked. She shook her head with a tiny motion. "When I found you, you were stuck in a tree on the side of the road. Your... traveling companion had fallen about 50 feet below and was very badly injured." Dan saw her eyes flick up to his face occasionally as he spoke. "I thought he was dead so I tried to get you out of the tree. But he wasn't dead. He started shooting at us. Do you have any idea why he would do that?" he asked gently. Tears were starting to well up in her eyes and she shook her head briefly. God, he wasn't ready to deal with tears. He rushed ahead. "I didn't have a choice. He kept shooting at you and managed to hit you twice. I couldn't reach him to stop him so I- I dropped a section of the guard rail on him and he fell the rest of the way to the bottom of the ravine. He didn't survive the fall. I'm so sorry! Was he your husband? A boyfriend?" Her eyes closed and the tears were forced out. A single tear rolled down each cheek. But strangely she seemed to relax a little. He heard her breathe out in a long sigh. Dan hadn't realized she was holding her breath. Then she spoke for the first time. It was almost a whispered croak. "Master." What she'd said didn't register with Dan. It had also been so quiet. "I'm sorry, what?" "Master," she said again. Dan sat back on his heels. This was way outside his area of experience. He shook his head and went back to his original question now that he got her talking. "OK, let's put that aside for now. I'd really like to know your name." Her eyes dropped back to his chest. His frustration surged and engaged his mouth before his brain regained control. "What did your Master call you?" As soon as the words left his lips he wished he could take them back. What a colossal asshole he was! This was exactly why he avoided being around people. "Whore... slut... bitch... cunt... cum-dump... fuck-hole," she immediately whispered, as if she wasn't at all disturbed by his cruel question. Dan was shocked. Then he considered the evidence of the physical abuse. Why hadn't he expected there to be mental abuse to go with it? She seemed to be having trouble with her throat. He caught her glance to the glass of water. God he was so stupid! She was parched and the glass of water was right there beside her. Full. She hadn't taken a drop though he could hear that her throat was raw. He took the glass and lifted it to her lips as he helped her sit up slightly. She sipped at first but when he didn't take it away she began to gulp at the water desperately. "Whoa, easy now. Drink slower or you'll make yourself sick," he said. She immediately stopped and dropped her eyes again. "I didn't say you should stop drinking. If you want more, please drink. Just take smaller sips. Let your stomach adjust," he said, using as calm a voice as he could. She glanced up again then she began to sip at the water. When it was almost gone she pulled back slightly so he put the glass back on the end table and allowed her to settle back on the bed. He was realizing that she wasn't going to collapse in grief with the loss of her "master" and that was a tremendous relief for Dan. She still seemed to be a little nervous but was no longer looking to the doorway every few seconds. So, he was probably right when he'd guessed she was expecting the man to arrive. That was one BIG concern out of the way, for both of them it seemed. "Look, I'm not going to use those names on you so I'd prefer your real one." Her eyes flicked up to his face once. "Do you remember your name?" he asked. She paused then shook her head. How could you not recall your own name? What the hell had been done to her? Well, he couldn't just give her a name. Assigning her a name like Mary, Joan, or Brenda just felt wrong. But a nickname might be okay. It was a friendly gesture as long as the name didn't offend. He thought about what his Mom would have said if she had been alive to meet this young woman. First thing she'd do is feed the poor dear as she was so 'willowy'. His mom loved those old genteel expressions. He smiled at the memory of his mother. He looked at the woman and decided that 'Willow' really did suit her. Gracefully slender and lithe. At least it did now with her underfed body. He'd have to be careful how he approached this. He didn't want to hurt her feelings. "Would you mind if I called you 'Willow' until you recall your real name?" he asked gently. She looked into his eyes with surprise. Even her mouth made a cute little o shape. When she realized she was keeping eye contact she quickly looked down but he could see a smile forming on her lips which she tried to hide. She gave him a little nod in agreement. It was time for him to follow his mother's 'advice' and get some food into her to begin her restoration. "OK 'Willow', I'm going to go make us some breakfast. Considering you look like you haven't eaten in a while I'm going to have you start with some warm porridge and we will see how your stomach handles that. If you are fine by lunch I will start slowly increasing your portions from that meal onwards. Is that okay with you?" She gave him another small nod though she kept her eyes down. He was getting a little exasperated by that but he wouldn't push her. "I'll just step out to the kitchen to prepare the food. You should get dressed and come meet me there when you are ready, okay? It's just down the hall to the left." He went to the kitchen and prepared breakfast for them both. Porridge for her and eggs for him. The simple act of cooking settled his nerves. Dealing with people was still very difficult for him. He always felt so uncomfortable around people and always said the wrong things. As he worked on preparing the meals he realized that it actually felt good taking care of someone other than himself. He hadn't realized how much he'd missed it with his self-imposed isolation. He hadn't heard her enter the kitchen so he jolted a little when he turned back from the fridge to find her standing topless at the end of the counter. She was wearing his socks and track pants but was holding the shirt and bikini top in her hands. He was so surprised he dropped an egg from his nerveless fingers. His eyes locked on her chest until the egg cracked on the floor at his feet. He glanced down and said "Shit!" Willow's expression froze and she dropped down before him and knelt with her forehead pressed to the floor. Her hair fell over the broken egg and soaked it in. He could see she was trembling. Grabbing some paper towels he knelt down and gently took her shoulders in his hands. She flinched deeply at his touch at first but he helped her sit back on her heels then he used the paper towels to sop up the raw egg in her hair. She'd need to wash it but first he wanted her to eat something so she wouldn't pass out in the shower. She kept her eyes down looking at the floor. He did his best to keep his eyes off her chest. "Willow, you didn't do anything wrong. Even if you had I wouldn't expect you to kneel at my feet. okay? I don't know what that guy did to you but you aren't going to be treated poorly here." Her trembling slowed to a stop as the beating she was expecting didn't happen. She cautiously glanced at his face and saw he had an uncomfortable smile. She was obviously confused and looked back down again. "Can I ask you why you are topless?" he asked gently. Willow held out the bikini top. She held it against her chest but he could see she didn't know how to tie the straps. He'd never tied one of these before either but she didn't even seem willing to try. He helped them both stand. Steeling himself to consider this as just another engineering puzzle he could help her without being embarrassed by the personal nature of the task. Standing this close to her he realized that she was actually a couple of inches taller than his 5' 8". He actually had to look up a little to look in her eyes. It was then, when he was just inches from her face that he noticed her eyes. They were the most amazing shade of green with gold flecks. Finding himself getting lost in her eyes he pulled himself back to the task at hand. He took the bikini top from her and tied the top straps together and slipped the loop over her head. Then he got behind her and pulled the bottom strings under her arms and tied it in a bow on her back. He came back around to her front to see if he'd tied it correctly. Her large breasts were straining at the fabric and spilling out of the bottoms. He realized he should have tied the lower string first to provide support under her heavy breasts then tie the top strap to lift the flesh up into a comfortable position. She stood quietly with no expression on her face while he redid the ties. Soon she was looking spectacular in the silky bikini top though it was a little small and struggled to support her bounty. The small gold rings in her nipples could easily be seen pushing against the fabric. Willow shyly looked into his eyes and he was surprised to see a little desperate need there. Like she was looking for acceptance or praise. He was a little uncomfortable but words sprung to his lips automatically. "You look truly lovely!" And she did, aside from looking like she was starving. She certainly had the frame and foundation for true beauty. If she hadn't been so neglected she would be gorgeous. Her expression underwent a strange transformation at his words. She looked shocked at first, like she'd never heard someone mention her beauty before. Then her eyes welled up with tears and she bit her lower lip. She lowered her eyes again but the smile stayed on her lips. Dan took his fleece shirt from her hand and held it out for her to place her arms into the sleeves. He turned her around once the shirt was over her shoulders so he could button up the front. He really needed to hide her amazing tits as his erection was threatening to split his jeans. Having his hands so close to them was not helping. He grabbed some more paper towel and wiped up the remains of the dropped egg. Then he turned back to their breakfast and allowed the homey activity take his thoughts away from Willow's beauty and the tightness developing in his pants. When he was finished he noted that she was still standing exactly where he'd left her. Dan raised an eyebrow and pointed to the chair at the small table by the window. She went to the chair and sat. He placed the full bowl and spoon before her and went back to get his own meal. When he returned he could see her eyes were fixed on the bowl but she hadn't moved. The scent of its rich flavor was gently rising in the steam towards her face and Dan saw a line of drool had tracked from the corner of her mouth to drop to her lap from her chin. "Willow? Willow!" Dan said, trying to get her attention. She jumped slightly then flinched, expecting a slap. "It's okay, you can eat. I made sure it's not too hot. It's safe," he said gently. She lifted the spoon awkwardly then scooped a good amount into her mouth. She froze when the porridge hit her tongue. Her eyes closed in bliss as she rolled the warm porridge across her tongue then swallowed it. She glanced at Dan from under her bangs then quickly took another scoop, then another. Accelerating. Dan reached out and gently took her hand. She froze and looked down, trembling. "Willow, it's okay. Just eat slower or you might make yourself sick. We have all the time in the world. Enjoy your meal." He released her hand after making sure she'd keep the spoon in it. She glanced at him then slowly scooped out another spoonful and slowly put it in her mouth, all the while keeping an eye on him for his approval. Dan felt ridiculous. She was a grown woman and she was asking him to show her how to eat? Before his buzzing nerves provoked him into saying something stupid again he took a deep breath and began to eat his own breakfast. Out of the corner of his eye he saw that she was matching his pace exactly. He'd lift his food to his mouth and she'd lift her spoon to her mouth. He sighed and wondered again what had happened to her to make her this way. She almost seemed desperate for his approval. Didn't she realize she was free of that moron? After breakfast they would need to have a little talk. Hmm... maybe after she showered. She was a little ripe, probably a by-product of her malnutrition. And he had to wash and mend her clothes. Soon he could hear the scrape of her spoon on the bowl as she went after the last morsels of her breakfast. He had probably given her a little too much but it was fairly easy on the stomach, very nutritious, and the extra helping of honey he'd added would start her on track to get some flesh back onto those bones. He poured her some sweet herbal tea to help warm her up and she sipped at this while he finished his own meal. He caught her eyeing a piece of bacon on the edge of his plate and she instinctively pinched her eyes shut and winced when she realized he'd seen her looking. Dan felt so helpless at seeing her fear, then it made him angry at the son-of-a-bitch who did this to her but he knew his anger would frighten her more, so he just let out a slow breath and tried to center himself. He picked up the bacon and held it out to her just before her lips. Willow's nose twitched as she smelled the bacon. Her eyes opened a little and she saw he was feeding her the piece. Something needful flared in her eyes again, making Dan uneasy, and she gently leaned forward to take the bacon into her mouth. As she closed her lips they softly kissed his fingertips. She shyly looked into his eyes again and this time he instinctively knew she was asking for something from him he was not prepared to give. Dan gave her a quick smile then gathered up the dishes and brought them over to the kitchen sink. He kept his back to her and willed his cock to relax. When her soft lips touched his fingers it felt like lightning running straight up his arm, down his spine, and straight to his groin. When he'd got his breath back he glanced over at her and saw she was still munching on the piece of bacon, getting as much enjoyment from it as she could. She glanced at him with a worried look then swallowed it. She still seemed anxious and a little lost, like she had somehow done something wrong and was looking for someone to give her the answer. Dan wished someone would give him some answers. First though, she needed a shower and he needed to fix her clothing situation. He knew that the shower in the master bathroom was where the soaps and shampoos were (he lived here alone after all). So she had better use his bathroom to clean up. He walked back to her and she glanced at his face briefly, trying to read his expression. "I think it would be good and you'll feel much better if you took a shower. You can use the one in my room. I'll get you some fresh clothes and a towel for you. okay?" Willow just nodded and stood up to follow him. He walked into the master bath and pulled a plush towel and a loofa sponge from the small linen closet. When he turned back to Willow she was completely naked and looking curiously into the big shower stall. The girl was not in the least bit self-conscious about being naked in front of him. Dan didn't scold her for being naked as he knew she would just be frightened so he kept his eyes on the shower stall as he pointed out the features and how to operate it. Once she seemed to understand the controls he continued. "Uh, um, the hot water is fed from an underground hot spring into an insulated storage tank and our cold water comes from a tank fed by a nearby stream so you won't run out of either. There are biodegradable soaps and shampoos on the rack there. Here's a new loofa scrub brush you can use as well. I'll leave you clean clothes on the counter just inside the door. I'll get these washed immediately after your shower," he said as he bent down and picked up the clothes she'd stepped out of. Dumping the dirty clothes inside and pulling the laundry bag from the hamper he turned to leave and felt a gentle tug at his sleeve. He looked back and she was standing very close, trembling slightly, looking down but stealing quick glances at his eyes. He could see that desperate need was back in her eyes. "Willow, please take your shower. You'll be fine now. We'll talk once you are done and dressed again, okay?" he said, his voice trembling slightly. God she was so beautiful but so damaged! He could really mess her up if he wasn't careful. To Be Continued in part 2, based on a post by BurntRedstone for Literotica
Today's guests are Priscilla Chan and Mark Zuckerberg, co-founders of Biohub (fka Chan Zuckerberg Initiative). They are one of the leading institutes for AI x Bio and open science research with projects like CELLxGENE, rbio1, VariantFormer, and many more. We talked about the evolution from a broad philanthropic institute to specializing in frontier AI + bio, why they are building 12ft tall microscopes to gather better data, and how building a virtual cell model + virtual immune system could potentially help us cure all diseases. Chapters 00:00:00 Introduction and CZI's 10-Year Anniversary 00:00:56 Learning from Bill Gates 00:04:05 Science vs Translation 00:10:45 The Power of Physical Proximity in Science 00:13:55 Building the Virtual Cell: From Data to Models 00:15:51 Microscopes, Imaging, and Converting Atoms to Bits 00:23:18 AI Meets Biology: The Frontier Lab Concept 00:27:25 How Models Can Enable More Ambitious Research 00:30:15 Precision Medicine and Clinical Impact 00:45:17 The Virtual Immune System and Cellular Engineering 00:48:27 Accelerating the Timeline: What It Takes to Cure All Disease 00:28:45 Joining Forces with Evolutionary Scale
Hydrogen infrastructure requires billion-dollar cryogenic systems. That's the conventional wisdom keeping hydrogen grounded. Dr. Jalaal Hayes proved it's wrong—and the implications for expeditionary operations are immediate.Hayes developed Liquid Organic Hydrogen Carriers (LOHC) technology, which stores hydrogen at ambient temperatures using existing fuel infrastructure. No specialized equipment. No cryogenic vulnerability. Combined with biohydrogen production, delivering three times the energy density of JP-8, this isn't an incremental improvement—it's an operational paradigm shift.When you orchestrate complementary technologies instead of betting on single solutions, you eliminate infrastructure dependencies that constrain deployment. For institutions like the DoW, that means hydrogen propulsion without forward-deployed cryogenic facilities.Paradigm Shifts:→ Applied Budgetary Exhaustion: LOHC eliminates billions in cryogenic infrastructure by using existing petroleum systems—the same asymmetric strategy Ukraine uses with $10K drones vs $100M platforms. Attack the cost structure, not the capability.→ Infrastructure Independence: Biohydrogen becomes deployable when paired with ambient-temperature LOHC storage. No cryogenic vulnerability. No specialized tankers. Existing logistics networks carry hydrogen in chemical form—released on demand at the point of use.→ Regional Stack Control = Supply Chain Security: Hayes built his entire prototype with suppliers within driving distance. That's not convenience—it's strategic autonomy. When you control the full stack regionally, you eliminate foreign dependencies and supply chain vulnerabilities.Operational Impact:→ Space-to-Ground Dual-Use: Same hydrogen stack enabling Mars closed-loop life support runs ground ops at forward operating bases. One R&D investment, two critical applications. That's how you maximize constrained budgets.→ Technology Intersection > Selection: Stop forcing teams to pick biohydrogen OR storage OR production. The breakthrough lives where they integrate—each solving the other's deployment constraint. Complementary systems outperform optimized components.→ Compressed Innovation Cycles: Hayes's students solve real commercial prototypes in semesters, not years. Academic-entrepreneurial integration accelerates the transition of capabilities from the lab to the field.Strategic Reframe: Infrastructure dependencies limit operational flexibility. When you orchestrate technologies that leverage existing systems, you eliminate deployment barriers. The question isn't "which hydrogen technology wins?" It's "what combination removes infrastructure constraints from our operational calculus?"Guest: Dr. Jalaal Hayes, CEO & Founder, Evince Inc. | Associate Professor of Chemistry, Lincoln UniversityHost: Dyan Finkhousen, Founder & CEO, Shoshin WorksEcosystemic Futures is the Shoshin Works foresight series with NASA - National Aeronautics and Space Administration heritage.
Alicia Silver, senior director at ADVI Health, highlights the evolving landscape of cell and gene therapy and the need to improve patient access and payment for these treatments. Availability of these therapies for solid tumors and genetic diseases like sickle cell disease is expanding due to the transition from inpatient to outpatient and community settings. The FDA's decision to remove REMS requirements for specific therapies has accelerated the growth of facilities to provide care, particularly for vulnerable populations. Alicia explains, "We work with a number of different cell and gene therapy clients throughout the sector. So we work with manufacturers who have commercialized cell and gene therapy products. So they have products that are currently on the market, manufacturers who are going through the process of clinical trials right now, working with the FDA to get approved products. But we also work with trade organizations that are working behind the scenes at the sector level, trying to get different policies and access changes for patients." "To date, there's probably close to a couple of dozen FDA-approved cell and gene therapies, and they treat everything from blood cancers, which were the first approvals in something called CAR T. We saw blood cancers as the first approvals, and then everything through to solid tumors in oncology. But also, we have newer gene therapies for conditions like sickle cell disease. And that's an area that's been incredibly underserved and definitely will benefit from a durable gene therapy that hopefully corrects some of the issues that patients with sickle cell disease have, like pain crises that end up in a hospital. So from that perspective, we see a really wide range of treatments available to patients today and many more on the horizon." "I think the price tag is definitely somewhat of sticker shock for people who don't understand how cell and gene therapy products are valued. And so what we do a lot of times, educating on, is helping payers understand that it's not necessarily $2 million for a treatment that's going to be a recurrent payment, but something that's kind of an investment in the patient's and the plan's future." #ADVIHealth #CellTherapy #GeneTherapy #AcesstoCellGeneTherapy #ClinicalTrials advi.com Download the transcript here
Alicia Silver, senior director at ADVI Health, highlights the evolving landscape of cell and gene therapy and the need to improve patient access and payment for these treatments. Availability of these therapies for solid tumors and genetic diseases like sickle cell disease is expanding due to the transition from inpatient to outpatient and community settings. The FDA's decision to remove REMS requirements for specific therapies has accelerated the growth of facilities to provide care, particularly for vulnerable populations. Alicia explains, "We work with a number of different cell and gene therapy clients throughout the sector. So we work with manufacturers who have commercialized cell and gene therapy products. So they have products that are currently on the market, manufacturers who are going through the process of clinical trials right now, working with the FDA to get approved products. But we also work with trade organizations that are working behind the scenes at the sector level, trying to get different policies and access changes for patients." "To date, there's probably close to a couple of dozen FDA-approved cell and gene therapies, and they treat everything from blood cancers, which were the first approvals in something called CAR T. We saw blood cancers as the first approvals, and then everything through to solid tumors in oncology. But also, we have newer gene therapies for conditions like sickle cell disease. And that's an area that's been incredibly underserved and definitely will benefit from a durable gene therapy that hopefully corrects some of the issues that patients with sickle cell disease have, like pain crises that end up in a hospital. So from that perspective, we see a really wide range of treatments available to patients today and many more on the horizon." "I think the price tag is definitely somewhat of sticker shock for people who don't understand how cell and gene therapy products are valued. And so what we do a lot of times, educating on, is helping payers understand that it's not necessarily $2 million for a treatment that's going to be a recurrent payment, but something that's kind of an investment in the patient's and the plan's future." #ADVIHealth #CellTherapy #GeneTherapy #AcesstoCellGeneTherapy #ClinicalTrials advi.com Listen to the podcast here
** AWS re:Invent 2025 Dec 1-5, Las Vegas - Register Here! **Trellix's Director of Strategy Zak Krider reveals how they automated tedious security tasks like event parsing and threat detection using Amazon Bedrock's multi-model approach, achieving 100% accuracy while eliminating bottlenecks in their development lifecycle.Topics Include:Trellix merged FireEye and McAfee Enterprise, combining two decades of cybersecurity AI expertiseProcessing thousands of daily security events revealed traditional ML's weakness: overwhelming false positivesTwo years ago, they integrated generative AI to automate threat investigation workflowsAmazon Bedrock's multi-model access enabled rapid testing and "fail fast, learn fast" methodologyBuilt custom cybersecurity testing framework since public benchmarks don't reflect domain-specific needsAgentic AI now autonomously investigates threats across dark web, CVEs, and telemetry dataAWS NOVA builds investigation plans while Claude executes detailed threat research analysisLaunched "Sidekick" internal tool with agents mimicking human developer onboarding processesChose prompt engineering over fine-tuning for flexibility, cost-effectiveness, and faster iterationAutomated security rule generation across multiple languages that typically require unicorn developersAchieved 100% accuracy in automated event parsing, eliminating tedious manual SOC workKey lesson: don't default to one model; test and mix for optimal resultsParticipants:Zak Krider - Director of Strategy & AI, TrellixSee how Amazon Web Services gives you the freedom to migrate, innovate, and scale your software company at https://aws.amazon.com/isv/
Did you miss us? Don't worry, we're back with all-new episodes to close out the year. First up is Tara Shifflett, chief of technology for the MAGS (Missiles, Aviation and Ground Systems) division of KBR's Defense and Technology Solutions business unit. Listen as Tara discusses the ins and outs of systems engineering, how KBR experts are using it to accelerate critical projects and democratize data and decision-making, and what's on the horizon in this exciting and game-changing field.
Send us a textIn this episode of Embedded Insiders, the VP of Sales and Business Development at Gateworks Corporation, Kelly Peralta, joins me to discuss the trends, challenges, and innovations surrounding Wi-Fi HaLow for industrial and IoT applications.The next segment is sponsored by Analog Devices, and Contributing Editor, Rich Nass, and Analog Devices' Senior Vice President of Software and Digital Platforms, Rob Oshan, discuss the complexity of designing AI systems and how Analog Devices' CodeFusion Studio, which includes an IDE, a software development kit, and coding tools, is designed to accelerate the process. Check out the embedded world North America 2025 Best-in-Show winners. For more information, visit embeddedcomputing.com
Coinbase (COIN) is "looking like it's in a really good place," says Ray Salmond. With retail interest gaining traction, the big concern he has for the stock is how the company can sustain current growth. David Siemer says it won't be much of a problem with Bitcoin and other stablecoin having "every possible tailwind." According to David, it may just take time for those tailwinds to develop.======== Schwab Network ========Empowering every investor and trader, every market day. Subscribe to the Market Minute newsletter - https://schwabnetwork.com/subscribeDownload the iOS app - https://apps.apple.com/us/app/schwab-network/id1460719185Download the Amazon Fire Tv App - https://www.amazon.com/TD-Ameritrade-Network/dp/B07KRD76C7Watch on Sling - https://watch.sling.com/1/asset/191928615bd8d47686f94682aefaa007/watchWatch on Vizio - https://www.vizio.com/en/watchfreeplus-exploreWatch on DistroTV - https://www.distro.tv/live/schwab-network/Follow us on X – https://twitter.com/schwabnetworkFollow us on Facebook – https://www.facebook.com/schwabnetworkFollow us on LinkedIn - https://www.linkedin.com/company/schwab-network/ About Schwab Network - https://schwabnetwork.com/about
In this episode, we speak with Matthew Ridley, Director of Sustainability and Innovation at the oneworld Alliance, who shares the story behind the groundbreaking $150 million Sustainable Aviation Fuel (SAF) fund launched in partnership with the alliance's member airlines and Breakthrough Energy Ventures (BEV).Ridley discusses:The alliance investment advantage: How pooling resources across oneworld members creates access to world-class venture capital expertise, superior deal flow, more diverse portfolios, and geographical networks.Breakthrough Energy's unprecedented value: Why partnering with BEV provides access to talent airlines struggle to attract, plus synergies with investments in nuclear fusion, energy transmission, and geologic hydrogen.Next-generation focus vs. current needs: How the oneworld BEV fund targets technologies that can take aviation beyond 5-10% SAF adoption to truly change the trajectory of decarbonisation, complementing existing investments.Breaking the alliance mould: How oneworld moved beyond traditional codeshares and interlining to tackle “initiatives of scale”, and how they attracted Singapore Airlines to join despite not being a oneworld member.Reframing aviation's challenge: Why the problem isn't aviation itself, but rather the emissions from jet fuel, the only aspect of flight that hasn't changed since the Kitty Hawk.Ridley also shares insights from his seven years building IAG's Hangar 51, where he led first-mover investments in ZeroAvia and LanzaJet, and explains why SAF isn't a transition fuel but rather a permanent solution once emissions are addressed.If you LOVED this episode, you'll also love the conversation we had with Pasha Saleh, Head of Corporate Development at Alaska Airlines, who shares how the airline is investing in sustainable aviation technologies to achieve its ambitious climate goals. Check it out here. Learn more about the innovators who are navigating the industry's challenges to make sustainable aviation a reality, in our new book ‘Sustainability in the Air: Volume 2'. Click here to learn more.Feel free to reach out via email to podcast@simpliflying.com. For more content on sustainable aviation, visit our website green.simpliflying.com and join the movement. It's about time.Links & More:Sustainability - oneworld oneworld becomes first airline alliance to join IATA CO2 connect - IATA oneworld airline partners join with Breakthrough Energy Ventures to invest in new SAF technologies - GreenAir News How Alaska Star Ventures is funding the future of sustainable aviation - SimpliFlying
China's Weakness and Global Geopolitical Shifts Guest: Gregory Copley Gregory Copley assesses the strategic implications of President Trump's Asia trip amid China's accelerating economic and political collapse. He notes Xi Jinping's apparent loss of consolidated power and the disarray within the People's Liberation Army command structure. Copley discusses emerging US and allied rare earth supply agreements designed to counter Chinese leverage in critical materials markets. He also highlights Turkey's continuing role in prolonging the Gaza conflict and analyzes the broader shift toward conservative, market-oriented governance across Latin America.
China's Weakness and Global Geopolitical Shifts Guest: Gregory Copley Gregory Copley assesses the strategic implications of President Trump's Asia trip amid China's accelerating economic and political collapse. He notes Xi Jinping's apparent loss of consolidated power and the disarray within the People's Liberation Army command structure. Copley discusses emerging US and allied rare earth supply agreements designed to counter Chinese leverage in critical materials markets. He also highlights Turkey's continuing role in prolonging the Gaza conflict and analyzes the broader shift toward conservative, market-oriented governance across Latin America. 1901
China's Weakness and Global Geopolitical Shifts Guest: Gregory Copley Gregory Copley assesses the strategic implications of President Trump's Asia trip amid China's accelerating economic and political collapse. He notes Xi Jinping's apparent loss of consolidated power and the disarray within the People's Liberation Army command structure. Copley discusses emerging US and allied rare earth supply agreements designed to counter Chinese leverage in critical materials markets. He also highlights Turkey's continuing role in prolonging the Gaza conflict and analyzes the broader shift toward conservative, market-oriented governance across Latin America.
China's Weakness and Global Geopolitical Shifts Guest: Gregory Copley Gregory Copley assesses the strategic implications of President Trump's Asia trip amid China's accelerating economic and political collapse. He notes Xi Jinping's apparent loss of consolidated power and the disarray within the People's Liberation Army command structure. Copley discusses emerging US and allied rare earth supply agreements designed to counter Chinese leverage in critical materials markets. He also highlights Turkey's continuing role in prolonging the Gaza conflict and analyzes the broader shift toward conservative, market-oriented governance across Latin America. 1906
On this episode of Accelerating Government, host Dave Wennergren talks with Doug Robinson, the executive director of NASCIO, about technology priorities for State CIOs. Guests:Doug Robinson, executive director, National Association of State Chief Information Officers (NASCIO). https://www.linkedin.com/in/robinsondoug/ Additional Resources:To learn more about ACT-IAC, please visit our website: https://www.actiac.org/ To learn more about NASCIO and read the 2025 State CIO Survey: https://www.nascio.org/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
PREVIEW: AI and Employment: The Unemployment Question Guest: Liz Peek Liz Peek notes the slow start to the national conversation about AI-driven unemployment despite the technology's accelerating impact. She questions the political reaction if mass layoffs begin across sectors. AI is already delivering massive productivity gains for large S&P 500 companies, causing their stocks to rise sharply. However, small businesses, represented by the Russell 2000 index, are currently being left behind. This divergence raises concerns about widening economic inequality and the need for proactive policy discussions about workforce transition and retraining in an AI-dominated economy.
In this episode of the Digital HR Leaders Podcast, host David Green is joined once again by Mikael Wornoo, Co-Founder of TechWolf - a company at the forefront of skills intelligence. Bringing fresh insights from the frontlines of AI and workforce strategy, together they explore where leading companies are heading, and what HR needs to do to stay ahead of the curve. From adoption challenges to ethical concerns, in this episode, you can expect to learn more about: How the conversation around AI and skills is shifting—and what's driving the change Why skills-based workforce planning is becoming a business-critical priority The human side of AI: navigating adoption, mindset shifts, and ethical concerns The data and insights HR needs to lead meaningful transformation How to build a fair, skills-powered future—and avoid a “winner-takes-all” dynamic This episode is sponsored by TechWolf. TechWolf helps enterprises get fast, accurate, and actionable skills data—without surveys. From identifying the skills your workforce has to mapping what they need, TechWolf's AI integrates seamlessly with your existing systems to turn messy data into strategic advantage. Learn more at techwolf.com Hosted on Acast. See acast.com/privacy for more information.
US Accelerates Moon Race Against China. Rick Fisher and David Livingston discuss how the US moon race is accelerating, driven by President Trump's demand to land on the moon by 2028 and concerns that China, using the Long March 10 booster, might get there by 2029. Interim NASA Director Sean Duffy reopened the lunar lander contract, previously held by SpaceX's Starship, to Blue Origin and potentially Lockheed Martin, seeking multiple pathways. The Chinese space program is viewed as a strategic maneuver aimed at distracting the US from other global conflicts.
US Accelerates Moon Race Against China. Rick Fisher and David Livingston discuss how the US moon race is accelerating, driven by President Trump's demand to land on the moon by 2028 and concerns that China, using the Long March 10 booster, might get there by 2029. Interim NASA Director Sean Duffy reopened the lunar lander contract, previously held by SpaceX's Starship, to Blue Origin and potentially Lockheed Martin, seeking multiple pathways. The Chinese space program is viewed as a strategic maneuver aimed at distracting the US from other global conflicts. 1954
Revelations from the red heifer ceremony, global digital IDs advancing, and the prophetic merger of politics and religion on full display in the Vatican. Peace deals are reshaping the Middle East — and could West Bank annexation plans cut off U.S. support for Israel? And Iran's Ring of Fire Rises Again! Don't miss today's dynamic open-line edition of The Endtime Show! 📱: It's never been easier to understand. Stream Only Source Network and access exclusive content: https://watch.osn.tv/browse 📚: Check out Jerusalem Prophecy College Online for less than $60 per course: https://jerusalemprophecycollege.com Learn more about your ad choices. Visit megaphone.fm/adchoices
Steve Yates Discusses Australia-US Alliance Strength and Political Turmoil Affecting APEC Summit Steve Yates with John Batchelor Steve Yates confirmed the Trump-Albanese meeting was a net positive, accelerating AUKUS and securing a rare earth deal that addresses supply access. He noted the political turmoil in Beijing, highlighted by uncertainty over Xi Jinping's APEC attendance. This instability is abnormal and reinforces China's unstable political foundation. Yates suggested this instability should push allies to rely more on the first island chain as a reliable balance. 1687
In this episode of the ChinaPower Podcast, John Culver argues that two seemingly contradictory trends define China's military this year: Xi Jinping's sweeping purge of senior PLA leaders and the PLA's rapid transformation into a far more lethal, joint-capable force. He notes unprecedented vacancies on the Central Military Commission and across theater commands—suggesting corruption is the excuse, not the cause—as Xi prioritizes loyalty and faster progress toward his ambitious reform goals. While 2027 isn't an “invasion deadline,” Culver says the PLA is racing to meet its centennial benchmarks, with September's parade showcasing a growing nuclear triad, serious investments in undersea warfare, and expanding unmanned aircraft. He cautions that any U.S.-created “hellscape” around Taiwan can be mirrored by China, which can produce equipment that is combat relevant in the Western Pacific at industrial scale. On gray-zone pressure, he casts China's Coast Guard as a paramilitary tool and says its ability to run a sustained blockade would hinge on complex command-and-control that it hasn't yet demonstrated in military exercises. Ultimately, Culver emphasizes that there is much about the PLA that remains unknown from the outside as Xi Jinping purposely keeps information opaque. This episode was recorded on October 15, 2025. John Culver is a nonresident senior fellow in the John L. Thornton China Center at Brookings. Prior to retiring from the Central Intelligence Agency in 2020, he served since 1985 as an analyst and manager on China, with a particular focus on the People's Liberation Army. From 2015 to 2018, Culver served as national intelligence officer for East Asia (NIO-EA). He was a founding member of the CIA's Senior Analytic Service, was in the Senior Intelligence Service, and was a recipient of the CIA's Distinguished Career Intelligence Medal, and the William L. Langer Award for extraordinary achievement in the CIA's analytic mission.