Podcasts about s1550

Diese Woche mit Sina Kürtz und Charlotte Grieser Ihre Themen sind: - Was Fasten mit der Libido zu tun hat (00:56) - Frauen und Miso-Paste im All (14:03) - Wie die Psychologie euer Beziehungsende voraussagt (20:31) - Erste deutsche Frau im All (28:20) Weitere Infos und Studien gibt's hier: Intermittent fasting boosts sexual behavior by limiting the central availability of tryptophan and serotonin https://www.cell.com/cell-metabolism/fulltext/S1550-4131(25)00104-4 Food fermentation in space: Opportunities and challenges https://www.cell.com/iscience/fulltext/S2589-0042(25)00450-X Terminal decline of satisfaction in romantic relationships: Evidence from four longitudinal studies https://psycnet.apa.org/doiLanding?doi=10.1037%2Fpspp0000551 Fragebogen zur Beziehungszufriedenheit: Self_Measures_for_General_Relationship_Satisfaction_RELATIONSHIP FaktAb-Folge “Warum es nicht schlimm ist, wenn wir in einem schwarzen Loch leben.” : https://www.ardaudiothek.de/episode/fakt-ab-eine-woche-wissenschaft/warum-es-nicht-schlimm-ist-wenn-wir-in-einem-schwarzen-loch-leben/ard/14329049/ Unser Tipp der Woche: ARD Wissen Doku „Besser leben“ Wie viel Tierwohl steckt wirklich hinter den Haltungsformen beim Fleisch? Was bringt ein Baum inmitten der Stadt eigentlich in Sachen Wärmeregulierung an heißen Tagen? Und welcher Käse ist vegetarisch, welcher nicht? Umweltfragen mit Alltagsbezug klären unsere Hosts Melitta Varlam und der Neue im Team, Florian Kienast, im Nachhaltigkeits-Podcast "Besser leben". Link: https://www.ardmediathek.de/film/die-cannabis-bilanz-wie-viel-kiffst-du-deutschland/Y3JpZDovL3N3ci5kZS9zZGIvc3RJZC8xNzMx Schreibt uns bei WhatsApp oder schickt eine Sprachnachricht: 0174/4321508 Oder per E-Mail: faktab@swr2.de Oder direkt auf http://swr.li/faktab Instagram: @charlotte.grieser @julianistin @sinologin @aeneasrooch Redaktion: Janine Funke und Chris Eckardt Idee: Christoph König

The Ultimate Glow-Up Guide ✨Want to wake up feeling and looking your best? In this episode, I'm sharing my top secrets that have completely changed the game for me—from the first thing you should do in the morning to the underrated habits that will leave you glowing from the inside out. We're talking hydration hacks, workout mistakes you might be making, skincare from the inside, and the one thing no one talks about but everyone notices. Trust me, you don't want to miss this one.★ MENTIONS:Find all my socials and everything else here: https://linktr.ee/levelingupwithlanaShop Products I Mentioned Here: https://shopmy.us/collections/825844Men/Women Workout Differences Study: https://pmc.ncbi.nlm.nih.gov/articles/PMC6230216/Excessive Exercise Hurts Your Metabolism Study: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00102-9Matcha/Green Tea and Acne Study: https://www.sciencedirect.com/science/article/abs/pii/S0965229916300280?via%3DihubThoughtX (my startup/podcast connection app): https://linktr.ee/thoughtx★ KEY WORDS:Confidence, wellness, pilates, fashion, motivation, goals, goal-setting, side hustles, faith, pink pilates princess, lifestyle, aesthetic, weightlifting, gym-life, “that” girl podcast, healthy, healthy food, lifestyle, luxury, workout, working out, consistency, discipline, self-care, self care, self love, business, entrepreneurship, friends, friendship, diet, weight-loss, healthy eating, morning routine, productive morning routine, 5 am club, christian girl, christian podcast, millionaire mindset, school year, 4.0 student, intuitive eating, anti-diet culture, organization, productivity, skincare, haircare, romanticize your life, tough-love, leveling up

In this episode of MakeFitSimple, Andrea kicks off the new year with an eye-opening discussion about ultra-processed foods and their surprising impact on overeating and weight gain. Inspired by a groundbreaking study from the National Institutes of Health, Andrea dives into the science of how these foods influence hunger hormones, appetite, and eating behaviors, even when calories and nutrients are matched with minimally processed foods. With practical tips on grocery shopping, meal prep, and building balanced plates, Andrea offers a realistic, judgment-free approach to making small, sustainable changes for a healthier you.Link to Study: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30248-7https://pubmed.ncbi.nlm.nih.gov/34647997/- Don't miss Andrea's Fitness App Make Fit Simple App TRY IT TODAY! FREE 30 day Trial if you click the link below https://www.deliciouslyfitnhealthy.com/app-sales-page-1Follow the Make it Simple Podcast@make.it.simple.podcast Have a suggestion for a topic click HEREHave a suggestion for a guest click HEREFollow Andrea on Instagram@deliciouslyfitnhealthy@dfh.training.picsTraining & Coachinghttps://www.deliciouslyfitnhealthy.com/linksVisit Andrea's Websitewww.deliciouslyfitnhealthy.comProduced by Light On Creative Productions

#186 - In diesem Video teile ich meine persönliche Reise, warum ich als Arzt im Bereich Abnehmen arbeite und wie ich zu diesem Thema kam. Ich erzähle von meinen persönlichen Erfahrungen, die mich stutzig gemacht haben und von den medizinischen Missverständnissen, die ich während meines Medizinstudiums erlebte. Meine eigenen Herausforderungen mit Gewicht und Gesundheit führten dazu, dass ich tief in das Thema Ernährung und Körperbewusstsein eintauchte. Ich bespreche, wie Übergewicht in der Medizin oft missverstanden wird und warum eine ganzheitliche Herangehensweise zur Gewichtssteuerung entscheidend ist. Es geht nicht nur um Sport und Ernährung, sondern auch um Schlaf, Stress und das Finden eines persönlichen „Warums“, um langfristige Veränderungen zu erreichen. Am Ende gebe ich dir Tipps, wie du selbst erfolgreich an deinem Wohlbefinden arbeiten kannst – ohne auf schnelle Diäten oder extreme Methoden zurückzugreifen. Viel Freude mit den Denkanstößen in dieser Folge! Unter folgendem Link findest Du die Beitragsseite: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.iamfasting.de/p186

[Werbung]  Die Folge wird präsentiert von FreeStyle Libre Messystem – dem derzeit kleinsten und flachsten Sensor der Welt. Nach einer Aktivierungszeit von 60 Minuten misst der Sensor jede einzelne Minute. Weitere Infos und Hinweise zum FreeStyle Libre Messsystem: https://www.freestylelibre.de/produkte/freestyle-libre-3-entdecken.html [Werbung] Show Notes Weitere Infos zu FreeStyle Libre 3https://www.freestylelibre.de/produkte/freestyle-libre-3-entdecken.html www.freestylelibre.de Erwähnte Seiten, Blogs etc. Quelle: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00623-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1550413121006239%3Fshowall%3Dtrue

In this eye-opening episode of the *Grow or Die* podcast, I take a deep dive into the oversimplified concept of "Calories In, Calories Out" (CICO). We explore why this approach to weight loss and metabolism is outdated, ineffective, and, in some cases, even harmful. I break down the science behind metabolism, dispelling common misconceptions and explaining how factors like basal metabolic rate, hormones, and nutrient absorption play critical roles in achieving and maintaining a healthy weight. You'll hear about real-world examples, like the contestants from The Biggest Loser and their struggles with weight regain, as well as the impact of severe caloric restriction on metabolism. We also cover the importance of understanding metabolic pathways, the role of polyunsaturated fatty acids, and how crash dieting can lead to long-term metabolic damage. Whether you're looking to optimize your health or curious about the science behind metabolism, this episode has the information you need to rethink how you approach weight loss.   Timestamps: - [00:28] – Sneak peek into the episode. - [1:41] – What is CICO, and why is it an oversimplification of human metabolism? - [2:41] – Why most people following CICO are unaware of metabolic dysfunctions. - [4:10] – How biofilms in the gut can impair nutrient absorption and affect metabolism. - [5:05] – The dangers of decreasing calories to unhealthy levels and how this impacts your metabolism long term. - [6:18] – The decline in metabolic rate over the last century and its contribution to rising obesity rates. - [8:09] – Explaining the second law of thermodynamics and why "a calorie is not a calorie" when it comes to metabolism. - [9:46] – The role of macronutrients in producing ATP and how different foods impact metabolism. - [11:54] – Debunking the idea that all fats and oils are created equal: Why polyunsaturated fatty acids may slow metabolism. - [14:07] – Lessons from historical diets and why past generations could eat more and maintain lower body weights. - [17:02] – The alarming rise in omega-6 intake and its negative effects on thyroid health and metabolism. - [20:36] – Why crash dieting leads to weight regain and long-term damage to basal metabolic rate. - [21:50] – How the body conserves energy during times of severe caloric restriction, and why this is counterproductive for weight loss. - [23:41] – The role of hormones in regulating metabolism, and how improper macronutrient ratios can harm thyroid health. - [27:16] – The benefits of prioritizing carbohydrates and lowering protein intake in certain health phases to boost metabolic function. - [31:00] – Why the majority of adults experience hypothyroidism and how modern blood tests miss the signs of metabolic dysfunction. - [35:12] – Actionable steps to improve metabolic health, including avoiding polyunsaturated fats, supporting liver function, and balancing hormones.   Links & Resources: Follow Me On Instagram: @jmihaly_ Follow "Grow or Die" On Instagram: @growordiepodcast Work With Me: https://www.togethermorefit.com/founder Join Substack For More Exclusive Content: https://justinmihaly.substack.com/ Join Patreon For More Exclusive Content: https://patreon.com/JustinMihaly?utm_medium=unknown&utm_source=join_link&utm_campaign=creatorshare_creator&utm_content=copyLink Sign Up For The Together More Elite Mentorship: https://togethermorefit.com/elitepurchase   Sources: 1. 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Show Notes 9 August 2024Story 1: Harvesting unused micro-vibration to generate electricitySource: NewsWise.com Link: https://d.newswise.com/articles/harvesting-unused-micro-vibration-to-generate-electricity/Story 2: Researchers invent 100% biodegradable 'barley plastic'Source: Phys.org Story by University of CopenhagenLink: https://phys.org/news/2024-06-biodegradable-barley-plastic.htmlSee also: https://science.ku.dk/english/press/news/2024/researchers-invent-one-hundred-percent-biodegradable-barley-plastic/Story 3: Embraer Introduces Automatic Takeoffs for E2 Family [of aircraft]Source: Aviation Week Story by Jens FlottauLink: https://aviationweek.com/shownews/farnborough-airshow/embraer-introduces-automatic-takeoffs-e2-familySee also: https://interestingengineering.com/transportation/embraer-world-1st-auto-takeoff-planesStory 4: Your Face's Heat Patterns Could Reveal Vital Clues About Your HealthSource: ScienceAlert.com Story by Carly CassellaLink: https://www.sciencealert.com/your-faces-heat-patterns-could-reveal-vital-clues-about-your-healthSee also: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(24)00188-8For more info, interviews, reviews, news, radio, podcasts, video, and more, check out ComputerAmerica.com!

In this episode, we delve into the role of NAD (Nicotinamide Adenine Dinucleotide) and its potential in treating Parkinson's Disease. NAD is a vital molecule involved in cellular energy production and DNA repair, but recent research suggests it may also play a crucial role in neuro-protection. How does NAD impact Parkinson's Disease? We'll explore: What is NAD and how does it function within our cells?  The connection between NAD and neurodegenerative diseases like Parkinson's.   Latest research findings on NAD's potential benefits for Parkinson's patients. How NAD supplementation could influence disease progression and symptoms. Join us as we uncover the science behind NAD and its promising potential in the fight against Parkinson's Disease. Remember to like, subscribe, and hit the notification bell to learn as much as possible about Parkinson's Disease. Resources: NADPARK Study (Full Text): https://www.cell.com/cell-metabolism/fulltext/S1550-4131%2822%2900045-6 Miscley et al ATPmax and NAD deficiency in PD: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961646/#B30-nutrients-15-00943 Need dedicated time to speak to a Parkinson's expert? Request a call here for up to 60 minutes: https://clarity.fm/pdeducation Help to support this channel and out efforts to educate the world about Parkinson's Disease and get access to personalized content:  https://www.youtube.com/channel/UC0g3abv8hkaqZbGD8y1dfYQ/join  https://www.patreon.com/pdeducation Please be sure to give support to our channel sponsors: Comfort Linen: https://comfortlinen.com/PARKINSONSDISEASEEDUCATION(15% off entire order when applying the code PARKINSONSDISEASEEDUCATION at checkout) Kizik Shoes: https://kizik.sjv.io/q4y1RL Orthofeet: https://lvnta.com/lv_0Pn1TAIM5VDdOHxlYG  If you have products that you would like for me to review on the channel please send them here: Parkinson's Disease Education P.O. Box 1678 Broken Arrow, OK 74013 Medical Disclaimer All information, content, and material of this video is for informational purposes only and not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider. Affiliate disclaimer: Keep in mind that links used for recommended products may earn me a commission when you make purchases. However, this does not impact what products I recommend. If I recommend a specific product it is because it has been vetted by myself or based on personal use #parkinson #parkinsonsawareness #parkinsonsdisease #parkinsons #atp #mitochondria #supplements

#170 - Künstlich hergestellte Lebensmittel sind so konzipiert, dass wir viel davon essen können. Diese Lebensmittel sind auf Haltbarkeit, Transport, Kosten und Geschmack optimiert. Eine Studie zeigt, dass wir etwa 500 kcal mehr pro Tag konsumieren, wenn wir hochverarbeitete Lebensmittel essen, was zu Gewichtszunahme führt. Dies ist kein individuelles Versagen, sondern ein systemisches Problem. Lösungen wie Intervallfasten können helfen, Kalorien zu kontrollieren. Wichtig ist, eine Balance zwischen Genuss und Gesundheitszielen zu finden, ohne sich auf Kalorienzählen zu konzentrieren. Flexible, individuell angepasste Strategien sind entscheidend, um langfristig erfolgreich zu sein und den JoJo-Effekt zu vermeiden. Viel Freude mit den Denkanstößen dazu in dieser Folge! Unter folgendem Link findest Du die Beitragsseite: ⁠⁠⁠⁠⁠www.iamfasting.de/p171

Today's show is how not to get overwhelmed and the concept of focusing on "One thing" in order to succeed. I talk about:Cutting sugar out of your dietHow addictive sugar is How food companies try and confuse us"that sugar show" documentaryEliminate all processed foodsHuge review of what UPF's do to our bodies Prioritize Protein The benefits of proteinEat protein first with every mealHow much protein to eatWhy it's important to maintain muscleHow protein helps keep you fuller longer Importance of the quality of proteinTime restricted eating Stop eating at least 2 hours before bed and whySpacing meals out 3 hours apartImportance of 3 meals a day with no snacking The importance of having 12 hours btwn your last meal of the day and your first meal the next morning. Studies referenced:https://www.unm.edu/~lkravitz/Article%20folder/exandwtloss.htmlactivates the opiate receptorsConnecticut College2008 Princeton studyhttps://www.bmj.com/content/384/bmj-2023-0773102019 studyhttps://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30248-7https://www.nature.com/articles/nutd20173https://pubmed.ncbi.nlm.nih.gov/15466943/https://pubmed.ncbi.nlm.nih.gov/16469977/https://www.ncbi.nlm.nih.gov/pubmed/16002798https://www.medicalnewstoday.com/articles/295901If you have more questions I would love to hear from you! I can be reached at tarawest@westwellnessatx.comYou can find out more about me and my practice here: https://www.westwellnessatx.com/

In episode 9, we had an informative discussion  with Jenny Chapman, a Churchill Fellow and food systems researcher. Jenny has a degree in Biology from the University of Oxford, a Masters in Taxonomy from Imperial College London, and a lifelong love of the natural world.  Her work has involved researching safe, healthy, sustainable and ethical protein sources. Jenny was awarded a Churchill Fellowship in 2023 to investigate the adoption, acceptance and trust of plant-based meat. Jenny recently published a report entitled' Processing The Discourse over Plant-Based Meat' which is an essential read for anyone who is trying to understand more about the “ultra-processed foods” debate. You can find her report here: https://www.churchillfellowship.org/ideas-experts/ideas-library/processing-the-discourse-over-plant-based-meat/ Reports and Studies Discussed: https://www.nationalfoodstrategy.org/ https://pubmed.ncbi.nlm.nih.gov/37356502/ https://pubmed.ncbi.nlm.nih.gov/31055621/ https://www.cell.com/cell-metabolism/pdf/S1550-4131(19)30248-7.pdf https://www.frontiersin.org/articles/10.3389/fnut.2022.826162/full https://www.thelancet.com/pdfs/journals/lanepe/PIIS2666-7762(23)00190-4.pdf https://pubmed.ncbi.nlm.nih.gov/35314769/ To connect with Jenny: https://www.linkedin.com/in/jenny-chapman-sustainability/

Welcome to this week's episode of Fast. Feast. Repeat. Intermittent Fasting for Life, with Gin Stephens and Sheri Bullock.To make a submission for the podcast, go to fastfeastrepeat.com/submit.  We are a community-driven podcast, and we look forward to sharing your questions, success stories, non-scale victories, IF tweaks, motivational quotes (and more!) on each episode of the podcast. Resources used in today's episode: TRE (the daily eating window approach) led to increased autophagy in mice. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00543-5https://www.beautycounter.com/sheribullock Email Sheri: sheri@fastfeastrepeat.comhttps://spiritualgrowthevents.com/events/inflammation-solution-docuseries-masterclass/ Go to fastfeastrepeat.com to see Gin's and Sheri's favorite things, and to shop with us.  Every purchase you make through links on our website help to support this podcast so we can keep bringing you episodes each week.  Want to learn more about BiOptimizer's Magnesium Breakthrough? Visit www.bioptimizers.com/fastfeastrepeat and use code FFR10 to save 10% off any order. Are you ready to take your intermittent fasting lifestyle to the next level? There's nothing better than community to help with that.  In the Delay, Don't Deny community we all embrace the clean fast, and there's just the right support for you as you live your intermittent fasting lifestyle. Connect with both Gin and Sheri in the community, as well as thousands of other intermittent fasters who are there to support you along your journey.  If you're new to intermittent fasting or recommitting to the IF lifestyle, join the 28-Day FAST Start group.  After your fast start, join us for support in The 1st Year group.  Need tips for long term maintenance? We have a place for that!  There are many more useful spaces beyond these, and you can interact in as many as you like.Visit ginstephens.com/community to join us. An annual membership costs just over a dollar a week when you do the math.  If you aren't ready to fully commit for a year, join for a month and you can cancel at any time. If you know you'll want to stay forever, we also have a lifetime membership option available.  IF is free. You don't need to join our community to fast. But if you're looking for support from a community of like-minded IFers, we are here for you at  ginstephens.com/community.

Oops, all science this episode! Erstwhile editorial assistant Deboki Chakravarti steps in for erstwhile everyman Sam Schultz as we parse through fundamental puzzles about humanity: what makes us, us, and if it is hormones, does that make us cocktails or cauldrons?SciShow Tangents is on YouTube! Go to www.youtube.com/scishowtangents to check out this episode with the added bonus of seeing our faces! Head to www.patreon.com/SciShowTangents to find out how you can help support SciShow Tangents, and see all the cool perks you'll get in return, like bonus episodes and a monthly newsletter! A big thank you to Patreon subscribers Garth Riley and Glenn Trewitt for helping to make the show possible!And go to https://store.dftba.com/collections/scishow-tangents to buy some great Tangents merch!Follow us on Twitter @SciShowTangents, where we'll tweet out topics for upcoming episodes and you can ask the science couch questions! While you're at it, check out the Tangents crew on Twitter: Ceri: @ceriley Sam: @im_sam_schultz Hank: @hankgreenHormones[Truth or Fail]https://vcresearch.berkeley.edu/news/trust-hormone-oxytocin-helps-old-muscle-work-new-study-finds[Trivia Question]Hormone-injected Judas goats to kill invasive species in Project Isabellahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092746/https://modernfarmer.com/2013/09/killing-goats-galapagos/[Fact Off]Bones make osteocalcin, which might be a hormone involved in stress reactionshttps://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30441-3https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335246/https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1008361https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1008714Chrononutrition and breast milk hormones training babies' circadian rhythms[Ask the Science Couch]Hormones (vs. neurotransmitters) and how they affect emotions Serotoninhttps://www.ncbi.nlm.nih.gov/books/NBK545168/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864293/ Testosteronehttps://www.sciencedirect.com/science/article/pii/S0033318213001333?via%3Dihubhttps://onlinelibrary.wiley.com/doi/10.1111/andr.12867 Estrogenhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753111/https://jamanetwork.com/journals/jamapsychiatry/fullarticle/210086 Thyroidhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612998/https://www.sciencedirect.com/science/article/abs/pii/S0378512215006064 Puberty in generalhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192018/https://journals.publishing.umich.edu/umurj/article/id/1383/[Butt One More Thing]Golden spiny mice poop hormones show that they've evolved to be nocturnal (even though they can be diurnal)https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0023446

These are six fundamentals to implement if you want to be more successful with nutrition this year. Links and resources: Ep. 48: “A comprehensive guide to meal planning and prepping” – https://podcasters.spotify.com/pod/show/fit-to-transform/episodes/A-comprehensive-guide-to-meal-planning-and-prepping---Ep--48-e24u13i  Research paper: “Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain: An Inpatient Randomized Controlled Trial of Ad Libitum Food Intake” by Hall et al., 2019 – https://www.cell.com/cell-metabolism/pdf/S1550-4131(19)30248-7.pdf  Sign up for one on one coaching with me: ⁠https://www.fittotransformtraining.com/coaching.html⁠ Follow me on Instagram @nikias_fittotransform: ⁠http://instagram.com/nikias_fittotransform/⁠ Visit my website: ⁠https://www.fittotransformtraining.com⁠ Sign up for my free newsletter: ⁠https://mailchi.mp/157389602fb0/mailinglist⁠ Sign up for the No Quit Kit email series on fat loss success: ⁠https://mailchi.mp/4b368c26baa8/noquitkitsignup⁠ --- Send in a voice message: https://podcasters.spotify.com/pod/show/fit-to-transform/message

If losing weight feels like a losing battle, this episode is for you. I'm joined by Gin Stephens, a science teacher turned fasting expert, who lost 80 pounds––and has kept it off for 10 years—with intermittent fasting.  In this discussion, we're talking about the hardest part of intermittent fasting: getting started. After speaking with thousands of people and discovering why they give up, Gin created a simple approach for establishing the habit, sticking with it, and finally seeing results. We cover common misconceptions about fasting, why intuitive eating may have failed you, and how achieving metabolic flexibility can change your relationship with food.   Plus, Gin shares her tips for dealing with hunger and cravings, and the magic of giving fasting a try for 28 days.    If your metabolic health is on your mind, this conversation is going to give you some serious food for thought.   FULL show notes: jjvirgin.com/cleanfast   Subscribe to my podcast: http://subscribetojj.com   Try my protein calculator: http://jjvirgin.com/proteinfirst   Read my book, The Virgin Diet: https://store.jjvirgin.com/products/the-virgin-diet-paperback Learn more about Gin Stephens: ginstephens.com   Listen to previous episodes with Gin Stephens: https://jjvirgin.com/?s=gin+stephens   Get 28-Day Fast Start Day-By-Day: https://amzn.to/3TiYzin   Read Fast. Feast. Repeat.: https://amzn.to/41i5Wsk   Read Delay, Don't Deny: Living an Intermittent Fasting Lifestyle: https://amzn.to/4aiLiwh   Read Clean(ish): Eat (Mostly) Clean, Live (Mainly) Clean, and Unlock Your Body's Natural Ability to Self-Clean: https://amzn.to/3TlYPNy   Listen to the Intermittent Fasting Stories podcast: https://www.intermittentfastingstories.com/   Join Gin Stephens's Delay, Don't Deny Community: ginstephens.com/community   Study: Cell Metabolism: Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain: An Inpatient Randomized Controlled Trial of Ad Libitum Food Intake: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30248-7   Study: Obesity: Persistent metabolic adaptation 6 years after "The Biggest Loser" competition: https://pubmed.ncbi.nlm.nih.gov/27136388/   Reignite Wellness™ All-In-One Shakes: https://store.jjvirgin.com/collections/shakes Get Gin Stephens' FREE Clean Fast Guide: http://ginstephens.com/cleanfast

There's a silent health crisis affecting millions of people—and you may be one of them. Chances are, you don't even know it.    What's this stealth threat? Poor metabolic health. And in this episode, I'm joined by nurse practitioner and intermittent fasting expert Cynthia Thurlow to get clear on what's causing this epidemic and what we can do to turn it around.    You'll learn why women are more likely to struggle, the two most pressing changes to make, when fasting might not be right for you, and how you can be proactive about reducing your risk of long-term disease.    Even if you're metabolically well, someone in your life likely isn't—and this episode could be the beginning of a journey to better health.    FULL show notes: jjvirgin.com/everydaywellness   Get my FREE Ultimate Health Roadmap: http://jjvirgin.com/ultimatehealth   Subscribe to my podcast: http://subscribetojj.com   Read my book, The Sugar Impact Diet: https://store.jjvirgin.com/collections/books/products/sugar-impact-diet-paperback-book   Learn more about Cynthia Thurlow: http://cynthiathurlow.com   Read Intermittent Fasting Transformation: https://amzn.to/46et3oC   Listen to Everyday Wellness: https://cynthiathurlow.com/podcast/   Study: Metabolic Syndrome and Related Disorders: Prevalence of Optimal Metabolic Health in American Adults: National Health and Nutrition Examination Survey 2009–2016: https://www.liebertpub.com/doi/full/10.1089/met.2018.0105   Monitor your metabolic health with YourLabWork: https://yourlabwork.com/jj-virgin/   Own Your Labs: https://ownyourlabs.com/ YourLabwork: jjvirgin.com/yourlabwork    Read The Ultimate Weight Solution by Dr. Phil McGraw: https://amzn.to/3QOmHa2   Study: Cell Metabolism: A Smartphone App Reveals Erratic Diurnal Eating Patterns in Humans that Can Be Modulated for Health Benefits: https://www.cell.com/cell-metabolism/pdf/S1550-4131(15)00462-3.pdf   Reignite Wellness™ All-In-One Shakes: https://store.jjvirgin.com/collections/shakes   Dr. Joe Dispenza meditations: https://drjoedispenza.com/?rfsn=6914154.37386a&utm_source=refersion&utm_medium=affiliate&utm_campaign=6914154.37386a   Designs for Health Inositol Capsules: https://amzn.to/46m9U4a   Reignite Wellness™ Clean Creatine Powder: https://store.jjvirgin.com/products/clean-creatine-powder   Designs for Health CatecholaCalm adaptogenic herbs: https://amzn.to/40KhunZ   Oura Ring: https://ouraring.com/   Whoop: https://www.whoop.com/us/en/   More episodes with Cynthia Thurlow: https://jjvirgin.com/?s=Cynthia+Thurlow   Check out Cynthia Thurlow's YouTube channel: https://www.youtube.com/cynthiathurlow   Follow Cynthia Thurlow on Instagram: https://www.instagram.com/cynthia_thurlow_   Follow Cynthia Thurlow on Twitter: https://twitter.com/_cynthiathurlow?lang=en   Join the Intermittent Fasting Lifestyle/Cynthia Thurlow Facebook Group: https://www.facebook.com/groups/1004505663061383/ Get Cynthia's FREE Intermittent Fasting Guide: https://cynthiathurlow.activehosted.com/f/27  

Sollten Frauen Intervallfasten, wenn sie nicht gerade abnehmen wollen? In dieser Folge erfährst du, ob Intermittent Fasting ungesund für die Hormonbalance von Frauen ist. Hierbei geht es auch um Hyperandrogenismus und das polyzystischem Ovarialsyndrom (PCOS). **Quellen:** https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182756 https://www.cell.com/cell-metabolism/pdf/S1550-4131(22)00393-X.pdf https://onlinelibrary.wiley.com/doi/full/10.1002/oby.23562 https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-021-02817-2 Hast du eine Frage zum Thema Ernährung (z. B. Kohlenhydrate, Kalorien, Fett, Protein, Verdauung, Darmgesundheit, Blähbauch, Diäten, Abnehmen, Fasten, Supplements etc.), dann schreib uns an: heisserpodcast@gmail.com

This episode covers:A study that shows the benefits of resistant starch, how to keep commitments to yourself, how your testimonial can make a difference, and more!Links mentioned during this episode:THANK YOU Campaign for Testimonials ($5 to charity!): bit.ly/lyonsthankyouThis Week's Blog Post (how to keep commitments to yourself): https://www.thelyonsshare.org/2020/10/19/how-to-stick-to-your-commitments-to-yourself/Resistant Starch Study: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00297-8NAFLD Podcast: https://podcasts.apple.com/us/podcast/e120-non-alcoholic-fatty-liver-disease-what-is-it-how/id1531030448?i=1000598457195Resistant Starch Powder: https://amzn.to/40dhlsXJoin Megan's Free Weekly Newsletter: www.thelyonsshare.org/newsletterMegan's Instagram: www.instagram.com/thelyonsshareLyons' Share Website: www.thelyonsshare.org

หลังจากจบตอนที่ 1 ของหัวข้อนี้ น้องๆได้ความเข้าใจเรื่องความเกี่ยวพันระหว่างดัชนีมวลกายกับเบาหวานประเภทที่ 2 รับทราบว่าการได้รับพลังงานล้นเกิน ในคนที่มีระดับเพดานกักเก็บไขมันใต้ชั้นผิวหนังต่ำ (Personal Fat Threshold) อาจเป็นต้นกำเนิดของเบาหวานประเภทที่ 2 ในตอนจบนี้พี่ปุ๋มจะนำเอางานวิจัยที่สำคัญของ Prof.Roy Taylor ศาสตราจารย์ด้านอายุรศาสตร์และเมตาบอลิสม เป็น Director of Magnetic Resonance Center อยู่ที่ University of Newcastle สหราชอาณาจักร มาสรุปให้น้องๆฟังกัน เขาเป็นผู้ตั้งสมมุติฐานของ Personal Fat Threshold ว่าเป็นต้นกำเนิด (Aetiology) ของเบาหวานประเภทที่ 2 และสมมุติฐานของ Twin Cycle Hypothesis พี่ปุ๋มจะนำงานวิจัยที่สำคัญของ Prof.Roy Taylor มาสรุปให้น้องๆได้ฟังกันนะคะ โดยเฉพาะงานวิจัยฉบับล่าสุดที่เพิ่งตีพิมพ์สดๆร้อนๆซึ่งเป็นการทดสอบสมมุติฐาน Personal Fat Threshold ของเขาที่สำคัญ ลิงค์อ้างอิงงานวิจัย 7 ฉบับ Cause of Insulin Resistance: The Personal Fat Threshold (ตอนจบ) 1. Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168743/pdf/125_2011_Article_2204.pdf 2. Very Low-Calorie Diet and 6 Months of Weight Stability in Type 2 Diabetes: Pathophysiological Changes in Responders and Nonresponders https://diabetesjournals.org/care/article/39/5/808/30678/Very-Low-Calorie-Diet-and-6-Months-of-Weight 3. Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial https://dacemirror.sci-hub.st/journal-article/54f864d9e758e0d7a4c02cc7d439d6c1/lean2017.pdf?download=true 4. Remission of Human Type 2 Diabetes Requires Decrease in Liver and Pancreas Fat Content but Is Dependent upon Capacity for β Cell Recovery https://www.cell.com/action/showPdf?pii=S1550-4131%2818%2930446-7 5. Aetiology of Type 2 diabetes in people with a ‘normal' body mass index: testing the personal fat threshold hypothesis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10472166/pdf/cs-137-cs20230586.pdf 6. From chronic overnutrition to insulin resistance: The role of fat-storing capacity and inflammation https://zero.sci-hub.st/1544/b69228f84ca76b1cfc1cd1bb4159b906/lionetti2009.pdf?download=true 7. Pathogenesis of type 2 diabetes: tracing the reverse route from cure to cause https://link.springer.com/content/pdf/10.1007/s00125-008-1116-7.pdf?pdf=button

Olá pessoal! André Burgos aqui, trazendo um resumo eletrizante da minha jornada de jejum de 5 dias até agora!

FREE RESOURCE - DOWNLOAD THE NEW  BLUEPRINT TO FASTING FOR FAT LOSS! Learn how to RAMP UP into longer fasting windows! Gain insights into the non-weight loss benefits of fasting! Personalize your own fasting schedule and consistent FAT LOSS results! Get answers to what breaks a fast, how to break a fast, and tips and tricks to accelerate your fasting wins!   THE BLUEPRINT TO FASTING FOR FAT LOSS DOWNLOAD   In today's episode, Dr. Scott and Tommy discuss why movement is the key to life, if exercise without weight loss improves insulin sensitivity, the effect of alternate day fasting with aerobic exercise on nonalcoholic fatty liver disease and so much more.   Show Transcript: www.thefastingforlife.com/blog   Nutrisense CGM LINK to Discount - Get $30 off and one-month free dietician support with the PROMO CODE “FASTINGORLIFE” www.nutrisense.io/fastingforlife   Let's continue the conversation. Click the link below to JOIN the Fasting For Life Community, a group of like-minded, new, and experienced fasters! The first two rules of fasting need not apply!   Fasting For Life Community - Join HERE   New to the podcast and wondering where to start? Head to the website and download our  Fast Start Guide, 6 simple steps to put One Meal a Day Fasting (OMAD) into practice!   Get our NEW sleep guide here! SLEEP GUIDE DIRECT DOWNLOAD   If you enjoy the podcast, would you please tap on the stars below and consider leaving a short review on Apple Podcasts/iTunes? It takes less than 60 seconds, and it helps bring you the best original content each week. We also enjoy reading them   Reference Links to Articles: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00538-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1550413122005381%3Fshowall%3Dtruehttps://examine.com/summaries/study/9Kv4E0/ https://diabetesjournals.org/care/article/26/3/944/29206/Does-Exercise-Without-Weight-Loss-Improve-Insulin https://pubmed.ncbi.nlm.nih.gov/16225477/ https://www.cdc.gov/physicalactivity/basics/pa-health/index.htm

Hvorfor får vi angstlidelser? Det er ikke bare dårlige matvaner, for stort alkoholdkonsum, lite søvn som gir oss emosjonelle utfordringer, humørsvingninger, tretthet, følelse av utilstrekkelighet og angst. Det er mange årsaker til angstlidelser, alt fra kjemiske prosesser i hjernen til genetikk, personlighet og ulike livshendelser kan trigge angst og panikkrelaterte følelser. Så mye som 31 % av verdens voksenbefolkning vil lide av seriøse angst i løp av livet Angst er den mest normale mentale «sykdommen» i USA og berører over 40 millioner amerikanere over 18 år hvert år. Kun 35 % av de som lider av angst oppsøker eller får behandling. I dagens mini episode deler vi egne erfaringer og snakker om angst, og ikke minst deler vi noen biohcaks og naturlige strategier som funker for oss. Vi snakker om tegn som kan fortelle deg noe om at angsten kontrollerer deg mer enn du ønske, som besettelse, unnvikelse, rastløshet og overplanlegging. Gode biohacks som en sunn tarmflora, nok bevegelse og søvn, og endel tilskudd vi liker som Gaba, magnesium, og flere mineraler. God lytt og del gjerne episoden med noen du tror vil ha glede av den. Kilder: www.daveasprey.com www.pubmed.com http://www.jneurosci.org/content/36/8/2449.short https://www.ncbi.nlm.nih.gov/pubmed/26894319 http://www.explorejournal.com/article/S1550-8307(16)30106-9/fulltext https://www.ncbi.nlm.nih.gov/pubmed/28445426 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040088/

***JOIN THE FASTING LIFESTYLE CHALLENGE THAT STARTS APRIL 5TH, 2023! New to fasting or want to get back on track? Struggling to break through a plateau? Ready to finally stop obsessing about your diet? Let's kick off April with intention, habit-building, and fast-tracking your fasting results!   We'll teach you how to FAST to LOSE FAT for good, and use 'fast cycling' to achieve uncommon results! Join us on April 5th for the 7-Day Fasting Lifestyle Challenge!  REGISTER HERE! Click the Link for DATES, DETAILS, and FAQ! APRIL 5th CHALLENGE REGISTRATION LINK   FREE RESOURCE - DOWNLOAD THE NEW  BLUEPRINT TO FASTING FOR FATLOSS! Learn how to RAMP UP into longer fasting windows! Gain insights into the non-weight loss benefits of fasting! Personalize your own fasting schedule and consistent FAT LOSS results! Get answers to what breaks a fast, how to break a fast, and tips and tricks to accelerate your fasting wins! THE BLUEPRINT TO FASTING FOR FAT LOSS DOWNLOAD   In today's timely episode, Dr. Scott and Tommy discuss some detrimental eating habits, building your fasting lifestyle, late eating, and much more.   Show Transcript: www.thefastingforlife.com/blog   Nutrisense CGM LINK to Discount - Get $30 off and one-month free dietician support with the PROMO CODE “FASTINGORLIFE” www.nutrisense.io/fastingforlife   Let's continue the conversation. Click the link below to JOIN the Fasting For Life Community, a group of like-minded, new, and experienced fasters! The first two rules of fasting need not apply!   Fasting For Life Community - Join HERE   New to the podcast and wondering where to start? Head to the website and download our FREE Fast Start Guide, 6 simple steps to put One Meal a Day Fasting (OMAD) into practice!   If you enjoy the podcast, would you please tap on the stars below and consider leaving a short review on Apple Podcasts/iTunes? It takes less than 60 seconds, and it helps bring you the best original content each week. We also enjoy reading them   Research Links: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605877/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352874/ https://www.eurekalert.org/news-releases/966718 https://www.strongerbyscience.com/research-spotlight-late-night-eating/ https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00397-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1550413122003977%3Fshowall%3Dtrue  

Hello and welcome to the Wholistic Living Podcast. My name is Elena Bensonoff. In this episode of the Be The Hero Of Your Health series, we will be talking about the power of mitochondria. Every hero has a special power. I'm excited to tell you why your mitochondria are the secret power that helps you achieve healthy aging and chronic illness prevention. I want to share some little-known facts about this organelle to help you understand its role in your longevity so you can actively work to improve the health and efficiency of your mitochondria. First up, I'll share the basics of the role your mitochondria play in the body. Then we will discuss what happens when this important energy powerhouse malfunctions. Finally, I'll reveal 5 ways you can boost your mitochondrial function. To close out today's episode, I want to remind you to check out my free Masterclass: https://www.wholistic.com/inner-healer-masterclass-invite Learn more about three daily habits that can significantly boost your long-term wellness! It just takes 60 minutes of your time and you will be amazed at the results you'll experience right away when you try out the techniques I share in the class. Thank you so much for listening. Many Blessings! References: https://www.lhsc.on.ca/medical-genetics-program-of-southwestern-ontario/all-about-mitochondria https://caltonnutrition.com/micronutrients-for-your-mitochondria https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912461/ https://encyclopedia.pub/entry/8923 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516748/ https://www.frontiersin.org/articles/10.3389/fnut.2022.858320/full https://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30099-2

Layne completed a BS in Biochemistry and a PhD in Nutritional Sciences, honing his intellectual skills under Dr. Donald Layman, one of the foremost researchers on protein metabolism and fat loss in the world. He has also enjoyed success in bodybuilding, winning a natural pro card in 2006. He is the founder of BioLayne. He created the company to provide ethical, science-based coaching that synthesized real world experience with evidence based protocols. In his coaching career he has turned over 70 people pro and reshaped the way that countless people think about nutrition. https://biolayne.com   GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org   SHOW NOTES: (9:51) There is no “one-size-fits-all” prescription in the fitness and nutrition space. (19:50) There is no such thing as “good” and “bad” foods. (24:15) Nuance is king in the fitness and nutrition space. (31:36) Don't sweat the carb/fat debate. (49:01) Layne doesn't claim to be an arbiter of truth; but, he's all for intellectual honesty. (1:03:00) Brian and Layne debate on common points of contention in nutritional science. (1:22:30) It's much easier to live an unhealthy life today compared to just three decades ago.   Learn more about the individuals and studies we mentioned in today's episode: Dr. Ted Naiman: https://www.dietdoctor.com/authors/dr-ted-naiman-md “Co-consumption of Vegetables and Fruit, Whole Grains, and Fiber Reduces the Cancer Risk of Red and Processed Meat in a Large Prospective Cohort of Adults from Alberta's Tomorrow Project”: https://www.mdpi.com/2072-6643/12/8/2265 Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain: An Inpatient Randomized Controlled Trial of Ad Libitum Food Intake: https://www.cell.com/cell-metabolism/pdf/S1550-4131(19)30248-7.pdf   GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org   Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

On this week's podcast, Drs.Feigenbaum and Baraki review the management of obesity. Sponsors: https://generalleathercraft.com/ References: Clinical Practice Guideline for the Evaluation and Treatment of Children and Adolescents With Obesity https://publications.aap.org/pediatrics/article/doi/10.1542/peds.2022-060640/190443/Clinical-Practice-Guideline-for-the-Evaluation-and?autologincheck=redirected Clinical Practice Guidelines For Healthy Eating For Prevention and Treatment of Metabolic and Endocrine Diseases in Adults by AACE https://www.endocrinepractice.org/action/showPdf?pii=S1530-891X%2820%2943460-3 2022 American Society for Metabolic and Bariatric Surgery and International Federation for the Surgery of Obesity and Metabolic Disorders: Indications for Metabolic and Bariatric Surgery https://www.soard.org/article/S1550-7289(22)00641-4/fulltext The importance of gene–environment interactions in human obesity https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381863/ Four-Year Weight Losses in the Look AHEAD Study: Factors Associated with Long-Term Success https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183129/ Orlistat Augments Postprandial Increases in Glucagon-like Peptide 1 in Obese Type 2 Diabetic Patients https://pubmed.ncbi.nlm.nih.gov/15111524/ GLP-1 physiology informs the pharmacotherapy of obesity https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8859548/ The dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist tirzepatide: a novel cardiometabolic therapeutic prospect https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8613929/ Seminars https://www.barbellmedicine.com/seminars/ For more of our stuff: App: https://tinyurl.com/muus5pfn Podcasts: goo.gl/X4H4z8 Website: www.barbellmedicine.com Instagram: @austin_barbellmedicine @jordan_barbellmedicine @leah_barbellmedicine @vanessa_barbellmedicine @untamedstrength @derek_barbellmedicine @hassan_barbellmedicine @charlie_barbellmedicine @alex_barbellmedicine @tomcampitelli @joe_barbellmedicine @rheece_barbellmedicine @cam_barbellmedicine @claire_barbellmedicine @ben_barbellmedicine @cassi.niemann @caleb_barbellmedicine Email: info@barbellmedicine.com Supplements/Templates/Seminars: www.barbellmedicine.com/shop/ Forum: forum.barbellmedicine.com/

I don't want to be disparaging, but there is some massive confusion from inaccurate data posted about BHB and R,1-3 Butanediol. What are those? And what do we need to take for performance gains? Let's get into it. +++++++++++++++++++++++++++++ In this video, let's discuss the scientific difference between ketone esters like Delta G, and other “ketone drinks” that contain just BDO, or R-1,3-BDO, such a Ketone IQ. Delta G Is 1 part BHB and 1 part R-1,3 Butanediol. Ketoneaid has products that mimic both, which is a great third party to compare these other two big brands to. More on that in the video! (What are "hard ketones"?) Others like Ketone IQ, HVMN are just BDO Ketonaid has a drink that is both, and also some marketed to get you buzzed. R1,3 Butanediol is an alcoholic ketogenic precursor, not a ketone ester, and we'll talk about how this negatively affects performance AND some really bad test results in a study. The Delta G CEO even tried with @darpa and @nihgov to use 1,3 Butanediol because it was cheaper to make, however it was discarded since it was getting subjects drunk +++++++++++++++++++++++++++ Podcast with Frank from Ketoneaid: https://insideouthealth.libsyn.com/frank-llosa-the-truth-about-ketone-esters-and-how-to-spot-deceiving-marketing Ketoneaid HARD KETONES: https://shop.ketoneaid.com/collections/all/products/r-1-3-butanediol Check all academic ketone studies on our website or on the @nihgov website. 1,3B on cycling, intoxication https://pubmed.ncbi.nlm.nih.gov/30632425/ Glycogen Sparing: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30355-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1550413116303552%3Fshowall%3Dtrue ++++++++++++++++++++++++++++++++ Full Blog With Training Tips: www.evoq.bike/blog Subscribe to Our Newsletter: http://eepurl.com/ggRc4n Follow Along on Strava: https://www.strava.com/pros/5889 EVOQ Training Packs: https://www.evoq.bike/training-packs TrainingPeaks Store Programs: https://www.trainingpeaks.com/training-plans/search?language=en&sort.field=soldCount&sort.dir=desc&keyword=evoq&index=0 Ketones, Delta G Tactical: https://www.deltagketones.com/products/g-tactical CODE Brendan for 15% off Lactigo: www.lactigo.com/brendan MORE WATTS and LESS BURN Airofit: https://www.airofit.com/?sca_ref=476545.3AVnm3vdGW Best Chamois Cream: https://www.hellobluecbd.com/, Code Brendan Codyceps Mushrooms: www.realmushrooms.com, Code EVOQ.BIKE Best shades: https://www.julbo.com/en_us/ --- Support this podcast: https://anchor.fm/evoqbike/support

Processed vs Unprocessed Foods Study: https://www.cell.com/action/showPdf?pii=S1550-4131%2819%2930248-7 If you'd like to join the free Coach Fitzz Facebook Group for workouts, recipes, form tips, and much more click: www.facebook.com/groups/fit40family/ Find me on… Website ► https://coachfitzz.com/ Email ► coachfitzz1@gmail.com Instagram ► https://www.instagram.com/coach_fitzz/?hl=en TikTok ► https://www.tiktok.com/@coach_fitzz?lang=en

I tried ketones, or what I THOUGHT were ketones, and nothing happened. Some friends reached out about DeltaG ketones so I've been testing them and WOW what a difference in product. I'll be doing a follow up video to discuss the popular ketones on the market, and what they actually contain: Delta G vs. HVMN vs Ketoneaid etc etc. We had 5 major questions on Instagram, so before I get more into how amazing these are and the science, let's do Ketones Part 1. Or Ketones 101! Delta G Tactical: https://www.deltagketones.com/products/g-tactical CODE Brendan for 15% off Ketone Meter: https://amzn.to/3SCvyKA Glycogen Sparing Study: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30355-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1550413116303552%3Fshowall%3Dtrue Full Blog With Training Tips: www.evoq.bike/blog Subscribe to Our Newsletter: http://eepurl.com/ggRc4n Follow Along on Strava: https://www.strava.com/pros/5889 EVOQ Training Packs: https://www.evoq.bike/training-packs TrainingPeaks Store Programs: https://www.trainingpeaks.com/training-plans/search?language=en&sort.field=soldCount&sort.dir=desc&keyword=evoq&index=0 --- Support this podcast: https://anchor.fm/evoqbike/support

The terms “processed” and “ultra-processed” are used in the health and wellness space to describe certain types of foods based on the processing that they've undergone. There are a number of problems with these terms when used to describe food, especially since most people associate “processed food” with being unhealthy, bad for you, toxic, junk, etc. At best these terms are vague and not particularly helpful but in many cases, referring to foods in this way negatively impacts our relationship with food. In this episode, I touch on the topic of how to approach "processed" foods in the context of Intuitive Eating and our relationship with food. If you enjoy diving into the primary research as I do, the paper that I reference in this episode (PMID: 31105044) can be found at the following link: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30248-7 ========================== If you'd like to contact me to work together, provide feedback on the podcast, ask clarifying questions, provide a suggestion for a guest or future episode, or for any other reason you can find me at: IG: @intuitive.eating.men Web: hopedrivesme.com

Where were you in 2015? President Obama was in the White House, The UK was a member of the European Union, and you couldn't escape Bruno Mars's global smash: Uptown Funk. More importantly, 2015 marked the release of Tim Spector's first book: The Diet Myth. If you think the world has felt different since 2015, wait until you hear about the advances in nutritional science. Since then, Tim has had a chance to rethink his position on dietary staples like bread, milk, ultra-processed foods and more.  He's put everything he's learnt into his new book Food for Life: The New Science of Eating Well.  In this episode, Tim speaks with Jonathan about what he got right, where he went wrong, and what the future holds for the world of nutrition.  https://www.tim-spector.co.uk (Tim Spector) is a co-founder at ZOE and one of the world's top 100 most cited scientists. If you want to uncover the right foods for your body, head to http://joinzoe.com/podcast (joinZOE.com/podcast) and get 10% off your personalized nutrition program. Timecodes: 00:00 - Intro 00:10 - Topic introduction 02:33 - Quickfire questions 03:19 - Has Tim changed his opinion on anything while writing his new book? 03:55 - Tim's new book: Food for Life 05:41 - Today's topic: 5 foods Tim got wrong 06:55 - #1: Bread 10:16 - What has Tim's opinion changed about bread? 12:23 - #2: Personalization 15:15 - How has Tim's breakfast changed? 22:05 - #3: Milk 25:04 - Skim milk vs whole milk 27:48 - What kind of milk does Tim have? 29:43 - #4: Mushrooms 32:37 - #5: Ultra-processed foods 40:30 - Summary 42:17 - Will Tim write another book? 42:49 - Goodbyes 42:53 - Outro Pre-order Tim's book https://amzn.to/3ySEIvG (here). Episode transcripts are available https://joinzoe.com/learn/category/nutrition/podcast (here). Check the trial mentioned in today's episode https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30248-7#section-e587233e-22aa-4221-8ae1-22df489d46f7 (here).  This podcast was produced by https://fascinateproductions.co.uk/ (Fascinate Productions).

 Introduction: Hey Everyone, I am Brad Dieter, the COO of Macros Inc, a nutrition and fitness coaching company and this is MI Take, a podcast that discusses current events in nutrition, the business side of the health and fitness industry, and a little of everything in between. Let's dive into it. Nutrition Insights: Daily food timing and how it may affect hunger.  Shifting meals later in the day may increase the total amount of experienced hunger in a given day, however adaptations to hunger may occur. There may be some minor shifts in metabolism that favor fat storage, but the outcome of that is not super clear.Paper 1: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00397-7Paper 2: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00344-8Business Insights: Updates on Peloton and Beach Body.Peloton Letter To ShareholdersPeloton Financial ReportsBeachBody Financial ReportsDEFAULT ALIVE: The goal is to play the long game and to stay in the game as long as possible. You learn a lot as you go along and the faster you learn the better. What I am learning Today: Being in the right place at the right time makes a major difference… and often is the only difference. Music from Tunetank.comAHOAMI - Cold Star (Copyright Free Music)Download free: https://tunetank.com/track/3535-cold-starMusic from Tunetank.comSquares MP - Chilling Time (Copyright Free Music)Download free: https://tunetank.com/track/6023-chilling-timeMusic from Tunetank.comIsaevIlnarMusic - Technologies Are Coming (Copyright Free Music)Download free: https://tunetank.com/track/4227-technologies-are-comingMusic from Tunetank.comomka - Vibes (Copyright Free Music)Download free: https://tunetank.com/t/6hvj/5019-vibes

This Week In Wellness a study published in Cell Metabolism has shown that eating late causes decreased energy expenditure, increased hunger, and changes in fat tissue that may increase the risk of obesity. https://www.sciencedaily.com/releases/2022/10/221004121928.htm https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00397-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2f Retrieve%2fapi%2FS1550413122003977%3Fshowall%3Dtrue The post TWIW 172: Eating late bad for metabolism, hunger and obesity risk appeared first on The Wellness Couch.

Society has come up with every diet imaginable in our journey toward living healthy, but rates of obesity continue to rise. Food journalist Mark Schatzker argues that tampering with the food we eat has harmed our ability to properly feed ourselves. MARK SCHATZKER is the author of The End of Craving, The Dorito Effect and Steak. He is a writer in residence at the Modern Diet and Physiology Research Center, which is affiliated with Yale University. His writing has appeared in the New York Times, the Wall Street Journal, Best American Travel Writing and Annual Review of Psychology. He lives in Toronto. LINKS Check out Mark Schatzker on Twitter, Instagram, and LinkedIn. See his website https://www.markschatzker.com for links to purchase his books. See some scientific studies mentioned in the interview and Schatzker's book:  • This 2020 in Cell Metabolism shows how artificial sweeteners can reduce insulin sensitivity and blunt brain response to sucrose https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30057-7 • This 2017 study in Current Biology suggests how artificial sweeteners disrupt normal physiological responses to carbohydrate ingestion https://www.cell.com/current-biology/fulltext/S0960-9822(17)30876-X?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS096098221730876X%3Fshowall%3Dtrue Learn more about Canada's permitted food additives and how they are regulated here.  https://www.canada.ca/en/health-canada/services/food-nutrition/food-safety/food-additives.html INSIGHTS 1. The stigma against people with obesity is that they are overindulgent or weak. “This is absolutely wrong,” says Schatzker. Instead, the brains of obese people respond to food differently. For example, at the sight of food, research has shown that obese people experience a spike in dopamine levels in their brains' reward centres. “The difference,” says Schatzker, “is one of craving.” 2. “We always thought that sweetness is this indulgent, enjoyable sensation,” says Schatzker. “It's actually like an instruction manual… for how much energy we're getting.” When our food contains additives like artificial sweeteners or fat replacers, it tastes like it should contain more sugar or fat than it actually does. “When there's this mismatch… the brain doesn't know what to do,” Schatzker says. “It kind of throws up its hands.” The uncertainty of how much energy we're getting leads the body to want to eat more, just to cover its bases. Which explains the obesity crisis in North America, where so much of the diet is processed (a.k.a. mismatched) food.  3. “We tend to think that our appetite is primitive and unhinged, and that there's something wrong with food,” says Schatzker. As a result, we've been adding things to our food to change its taste, texture, shelf-life or caloric content, and these additives have been directly altering our brains and the amount of food that we're driven to eat. To make matters worse, these additives are difficult to spot on ingredient labels. They're often called things that sound healthy and natural, like citrus fibre or milk protein (both fat replacers). 4. “If delicious food is a guilty pleasure, you would expect that Italians would be the heaviest people in the world,” says Schatzker. In fact Italy has one of the world's lowest obesity rates, and he credits that to Italy's cultural attitude toward mealtime, home cooking and savouring. “Eating is meant to be deeply pleasurable, so don't be afraid to enjoy real food. That's the way it's meant to be eaten,” he says. The content of our show is educational only. It does not supplement or supersede the professional relationship and direction of your healthcare provider. Always seek the advice of your physician or other qualified mental health providers with any questions you may have regarding a medical condition, substance use disorder, or mental health concern.  

There is so much misinformation out there about hormones and women's health, especially estrogen.So I'm excited to share my in-depth conversation with Dr. Felice Gersh about women's hormones and the different phases of perimenopause and menopause.We discuss the flawed study that generated so much fear and misinformation about estrogen and cancer, the difference between synthetic and bioidentical hormones, the role diet and your gut microbiome play in balancing hormones, and so much more.Dr. Felice Gersh is board certified in OB-GYN and Integrative Medicine. She taught as an assistant clinical professor at the Keck USC School of Medicine for 12 years and is the founder and director of the Integrative Medical Group of Irvine, California.A globally recognized expert on women's health, Dr. Gersh regularly speaks at conferences around the world and is also the best-selling author of PCOS SOS and her most recent book, Menopause: 50 Things You Need to Know about what to expect during the three phases of menopause.Listen to the full episode to hear:Why the hormone combination used in the Women's Health Initiative study caused so many problemsHow estrogen can actually protect you from reproductive cancers and why this changes with ageHow chronic pro-inflammatory states and hormonal imbalances contribute to the negative effects of agingWhy we are seeing more cancers in young, premenopausal womenHow endocrine disruptors in food and the environment contribute to rising rates of autoimmune disorders, cancers, and menstrual disorders like PCOSLearn more about Dr. Felice Gersh:Integrative Medical Group of IrvineInstagram: @Dr.FeliceGershFacebook: @IntegrativeMGILearn more about Sami:Eatfor.lifeBook Your Complimentary ConsultationEat For Life cookbooks for each unique biotypeResources:Women's Health Initiative is Fundamentally Flawed. Gender Medicine, Volume 2, Issue 1, 2005 https://doi.org/10.1016/S1550-8579(05)80003-8A Critique of the Women's Health Initiative Hormone Therapy Study. Fertility and Sterility, Volume 84, Issue 6, 2005 https://doi.org/10.1016/j.fertnstert.2005.08.010In Defense of Estrogen, Journal of Orthomolecular Medicine. Vol. 22, No. 3, 2007 https://isom.ca/wp-content/uploads/2020/02/JOM_2007_22_3_07_In_Defence_of_Estrogen.pdfEnvironmental Causes of Cancer: Endocrine Disruptors as Carcinogens. Nature Reviews Endocrinology, 363–370 (2010). https://doi.org/10.1038/nrendo.2010.87Polycystic Ovary Syndrome (PCOS) and Endocrine Disrupting Chemicals (EDCs). Reviews in Endocrine and Metabolic Disorders. 16, 365–371 (2015). https://doi.org/10.1007/s11154-016-9326-7

https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30253-5?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1550413118302535%3Fshowall%3Dtrue https://www.webmd.com/diet/news/20200624/behind-the-intermittent-fasting-fad

In Upfit Podcast #97 geht es um die Problematik, Informationen und Schlagzeilen rund um Ernährung blind zu vertrauen. Aber wie sieht denn der richtige Umgang mit Ernährungsinformationen aus? Wem und was kann man denn überhaupt noch glauben? Bekannte Studien und Ernährungsmythen werden genauer unter die Lupe genommen: Schokolade zum Frühstück soll beim Abnehmen helfen und Rotwein die Gesundheit unterstützen? Die Antworten auf diese Fragen und hilfreiche Tipps & Tricks, wie ihr eurem Ziel näher kommt, erfahrt ihr in der heutigen Podcastfolge. Kommentiert fleißig, stellt Fragen und abonniert unseren Kanal, um zukünftig keine Folge mehr zu verpassen. Webseite: upfit.de Instagram: instagram.com/upfit.de Facebook: facebook.com/upfit.de Youtube: youtube.com/channel/UCWRBa7-h8uCpfoXlbv1pdbQ Pinterest: pinterest.de/upfitme Links zu den Quellen: https://www.thesun.co.uk/fabulous/15392293/eating-chocolate-for-breakfast-supercharge-weight-loss/ https://www.grazia-magazin.de/lifestyle/wein-pro-woche-gesund-laut-studie-49026.html https://www.kenn-dein-limit.de/fakten-ueber-alkohol/ist-rotwein-gesund/ http://edition.cnn.com/2010/HEALTH/11/08/twinkie.diet.professor/index.html https://www.cell.com/cell-metabolism/pdf/S1550-4131(19)30248-7.pdf https://robertlustig.com/2019/07/2215/ https://www.dailymail.co.uk/femail/article-2601633/I-eat-51-bananas-day-Self-proclaimed-diet-guru-claims-toned-physique-MOUNTAINS-fruit-eats-single-meal-time.html https://herculeanstrength.com/eat-36-eggs-a-day-hormone-precursor-diet/ https://newsroom.ucla.edu/releases/Dieting-Does-Not-Work-UCLA-Researchers-7832 --- Send in a voice message: https://anchor.fm/upfit/message

Be Effective Zmíněná RCT studie od Kevin Hall: https://www.cell.com/cell-metabolism/pdf/S1550-4131(19)30248-7.pdf Videokurz, kde Tě naučím hubnout: https://www.naucmese.cz/kurz/video-jak-zhubnout-a-postavu-si-udrzet-bez-jidelnicku-bez-suplementu-100-zaruka-spokojenosti Patreon: https://www.patreon.com/martinbarna Kontakt na mě: barna@eftm.cz FB skupina pro Vás: https://www.facebook.com/groups/martinbarnanutrition Coaching - http://www.martinbarna.cz https://www.instagram.com/martinbarnanutrition/ https://www.facebook.com/martinbarnanutrition/

We eat for so many reasons – hundreds of them – other than hunger. Many of these reasons can be narrowed down into six main categories; some may surprise you. In this episode, we delve further into some of the root causes behind why we overeat, with specific guidance on how to break the cycle and develop a healthier relationship with food.LINKSPodcast with Dr. Dave Galarneau | Choose Joy www.podcasts.apple.com/us/podcast/choose-joy-strategies-to-de-stress-this-holiday-season/id1459883591?i=1000499440281Kevin Hall's 2019 study, Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain | link here: www.cell.com/cell-metabolism/pdf/S1550-4131(19)30248-7.pdfMolly's article about why we crave, why we feel addicted to food | link here: www.nola.com/entertainment_life/eat-drink/article_60c85823-8aa7-523e-9a23-1208236554f0.htmlNutrition Action Health Letter: Why We Overeat [April 2021] | excellent recap here: www.foodfactsandfads.com/2021/04/07/ultra-processed-food-and-obesity/Brand Specific Shopping Guide via Ochsner Eat Fit Smartphone App | www.play.google.com/store/apps/details?id=com.ochsner.eatfit&hl=en_US&gl=US

Dr Herman Pontzer is an internationally recognised researcher in human energetics and evolution. He has conducted pathbreaking studies across a range of settings, including fieldwork with Hadza hunter-gatherers in Northern Tanzania, chimpanzee ecology in the rainforests of Uganda, and metabolic measurements of great apes in zoos and sanctuaries around the globe. He recently released the book, Burn: The Misunderstood Science of Metabolism, a fascinating must-read. Nathan sat down with Herman and discussed major theories and research relating to metabolism, including the carbohydrate-insulin model of obesity, the role of the hypothalamus in energy expenditure and lesson learned from the Hadza tribe. *Highlights * The metabolic revolution (3:30) The additive model (14:00) How your brain controls energy expenditure (19:00) We eat what we can get our hands on (30:00) Re-examining the carbohydrate insulin model (36:00) Exercise helps you maintain weight loss (41:00) Studying Hudza life (50:00) Useful links and resources: e.g: Follow Metagenics on Instagram - @metagenics_anz (https://www.instagram.com/metagenics_anz/) Dr Herman Pontzer’s book - https://www.amazon.com.au/Burn-Misunderstood-Metabolism-Herman-Pontzer/dp/0241388422/ref=ascdf0241388422/?tag=googleshopdsk-22&linkCode=df0&hvadid=463870498773&hvpos=&hvnetw=g&hvrand=539011197377358903&hvpone=&hvptwo=&hvqmt=&hvdev=c&hvdvcmdl=&hvlocint=&hvlocphy=9068941&hvtargid=pla-1093754365871&psc=1 The Hadza Fund - https://www.hadzafund.org/ Study by Hall and colleagues “Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain: An Inpatient Randomized Controlled Trial of Ad Libitum Food Intake” - https://www.cell.com/cell-metabolism/pdf/S1550-4131(19)30248-7.pdf

Dr Herman Pontzer is an internationally recognised researcher in human energetics and evolution. He has conducted pathbreaking studies across a range of settings, including fieldwork with Hadza hunter-gatherers in Northern Tanzania, chimpanzee ecology in the rainforests of Uganda, and metabolic measurements of great apes in zoos and sanctuaries around the globe. He recently released the book, Burn: The Misunderstood Science of Metabolism, a fascinating must-read. Nathan sat down with Herman and discussed major theories and research relating to metabolism, including the carbohydrate-insulin model of obesity, the role of the hypothalamus in energy expenditure and lesson learned from the Hadza tribe. *Highlights * The metabolic revolution (3:30) The additive model (14:00) How your brain controls energy expenditure (19:00) We eat what we can get our hands on (30:00) Re-examining the carbohydrate insulin model (36:00) Exercise helps you maintain weight loss (41:00) Studying Hudza life (50:00) Useful links and resources: e.g: Follow Metagenics on Instagram - @metagenics_anz (https://www.instagram.com/metagenics_anz/) Dr Herman Pontzer’s book - https://www.amazon.com.au/Burn-Misunderstood-Metabolism-Herman-Pontzer/dp/0241388422/ref=ascdf0241388422/?tag=googleshopdsk-22&linkCode=df0&hvadid=463870498773&hvpos=&hvnetw=g&hvrand=539011197377358903&hvpone=&hvptwo=&hvqmt=&hvdev=c&hvdvcmdl=&hvlocint=&hvlocphy=9068941&hvtargid=pla-1093754365871&psc=1 The Hadza Fund - https://www.hadzafund.org/ Study by Hall and colleagues “Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain: An Inpatient Randomized Controlled Trial of Ad Libitum Food Intake” - https://www.cell.com/cell-metabolism/pdf/S1550-4131(19)30248-7.pdf

Wer die phantasiereichen Produktinnovationen der Lebensmittelindustrie genauer unter die Lupe nimmt, weiß, dass nicht alles, was uns im Supermarkt und Internet angeboten wird, die Bezeichnung „Lebensmittel“ – also Mittel zum Leben – verdient hat. Fake oder real? Die Frage passt nicht nur zu Nachrichten, sondern kann sich jeder auch beim Essen stellen. Rike und Heike gehen in dieser Podcast-Folge der Frage nach, was die sogenannten Fake Foods mit uns körperlich und emotional machen. Die beiden werfen wieder einen Blick in die Wissenschaft und berichten, was durch den Verzehr von hochverarbeiteten Lebensmitteln innerhalb weniger Wochen passieren kann. Du siehst dazu auch die Quellen unten. Doch wie immer werden die Studienergebnisse praxistauglich für den Alltag gemacht. Sehr hilfreich ist beispielsweise Rikes 80:20-Regel für den Einkauf. Und du erfährst auch, was du zwischen den Zeilen auf den Verpackungen von Lebensmitteln erkennen kannst, so dass dir die sogenannte Fressformel nicht zum Verhängnis wird. Viel Spaß beim Hören! Hier sind die Links zu den Studien, auf die wir im Podcast berichten: Small und DiFeliceantonio, 2019: https://science.sciencemag.org/content/363/6425/346 Hall et al., 2019: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30248-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1550413119302487%3Fshowall%3Dtrue Mehr von uns wie immer auch über unsere Website oder Instagram! https://www.essenz.hamburg/ https://www.instagram.com/essenz.hamburg/?hl=de Lust auf Körperglück zu Hause und überall? In Kürze startet auch der neue online-Kurs! Mehr Infos unter www.essenZ.hamburg/koerperglueck

This week, we talk about the ol’ tippy top of the food pyramid: Candy! When you get done with this tasty episode, you’ll be saying “how sweet it is!” And we’ve got some big news! SciShow Tangents has a Patreon now! Head to the link below to find out how you can help support SciShow Tangents, and see all the cool perks you’ll get in return, such as bonus episodes and a monthly newsletter! https://www.patreon.com/SciShowTangentsWe love making this show, and with your help we can make it even better!Follow us on Twitter @SciShowTangents, where we’ll tweet out topics for upcoming episodes and you can ask the science couch questions! While you're at it, check out the Tangents crew on Twitter: Ceri: @ceriley Sam: @slamschultz Hank: @hankgreenIf you want to learn more about any of our main topics, check out these links:[Fact Off]Cotton candy blood vesselshttps://www.designnews.com/stub/synthetic-capillary-networks-artificial-organs-developed-using-cotton-candy-machinehttps://www.eurekalert.org/pub_releases/2016-02/vu-ccm020816.phpCordite (forbidden gum)Picture: https://commons.wikimedia.org/wiki/File:Cordite_Filled_Cartridge.JPGhttps://trove.nla.gov.au/newspaper/article/3281990https://www.chemistryworld.com/podcasts/cordite/1010201.articlehttps://www.britannica.com/science/nitroglycerinhttp://www.gumassociation.org/index.cfm/science-technology/ingredients-technology/http://news.bbc.co.uk/2/hi/uk_news/6954562.stmhttp://pubsapp.acs.org/cen/whatstuff/85/8532sci2.html[Ask the Science Couch]Candy preferences with agehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764307/https://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30214-0https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.30.1_supplement.418.6https://now.tufts.edu/articles/craving-brain[Butt One More Thing]Sugar alcohol fartshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093271/#

The immune system has become a hot topic recently with COVID-19's spread but did you know that scientists can manipulate the immune system to fight cancer? In this episode we go over the basics of the immune system, discuss how cancer can hijack the immune system and introduce you to CAR-T therapy! // SOURCES Types of T-cells: https://www.celiackidsconnection.org/2018/05/06/what-are-the-different-types-of-t-cells/Great summary of the nature article: https://www.sciencealert.com/new-t-cell-therapy-kills-most-human-cancer-types-and-might-work-across-individualsHallmarks of cancer: https://blogs.scientificamerican.com/guest-blog/the-hallmarks-of-cancer-9-reprogramming-energy-metabolism/Journal article on glycolysis and immune system: https://www.cell.com/cell-metabolism/pdf/S1550-4131(18)30178-5.pdfPersonalis article: https://www.personalis.com/understanding-role-human-leukocyte-antigen-cancer-immunotherapy/What is CAR-T therapy: https://www.cartcellscience.com/car-t-cell-therapy-frequently-asked-questions/Lymphoma CAR-T: https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(17)30058-8?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1525001617300588%3Fshowall%3Dtrue#secsectitle0020

For full notes, transcript, and more, visit https://robbwolf.com/2020/04/10/keto-amenorrhea-polycystic-kidney-disease-diabetes-thrr024/ Make your health an act of rebellion. Join The Healthy Rebellion Please Subscribe and Review: Apple Podcasts | RSS This episode of The Healthy Rebellion Radio is sponsored by Four Sigmatic. Four Sigmatic is a wellness company that wants to share the benefits of the most nutrient dense ingredients with the world. Their innovative recipes combine these truly super foods with daily staples like coffee, cacao, and skincare to help you fit elevated wellness in throughout the day and meet the overwhelming demands of modern life. Go to foursigmatic.com/rebel and use code: REBEL, for 15% off     Show Notes:   News topic du jour: Methylglyoxal Content in Drinking Coffee as a Cytotoxic Factor 1. Keto and polycystic kidney disease [10:15] Megan Hi, my name is megan, I'm a 30 year old female with an inherited disease called polycystic kidney disease. I have many large cysts covering my kidneys and liver and with an MRI scan I have an 80 percent chance of reaching kidney failure before I turn 40. There is no cure for it, my grandfather passed away from it at 47 and my mom is on dialysis waiting for a transplant. There were some studies showing previously that calorie restriction and low body weight can slow cyst growth (I'm 5'4 and 126 pounds) and Recently, the Weimbs lab has done studies in rats and cats that have shown that the Keto diet with IF is reversing the disease completely.  The pkd foundation is wanting to start human studies but it wont be for a while. My nephrologist called keto the starvation diet when I approached him about it and told me it was too restrictin, would take too long to see  he would rather me eat less meat and more grains. I have experimented with keto and overall feel better with less flank pain. So my question is, I know that animals and humans react differently to these studies, but wondering if I should do the keto diet long term anyways, instead of wait for human trials to come out, or if it may do more harm than good with my low body weight and kidney issues. Thank you for your time. https://www.cell.com/cell-metabolism/pdf/S1550-4131(19)30515-7.pdf 2. Amenorrhea after two years on Keto [16:04] Kate says:: Hi, Robb and Nicki, I’m a big fan of the podcast and have had a dilemma weighing on me and wondered what y’alls input would be. See I have been on a the standard macro keto diet 70%fat 25%protein and 5%carbs for the past two years. I went keto after to my alarm going to the doctors finding my fasting blood sugar at 124mg/dL. I have experienced all the benefits of keto from normalized glucose levels throughout the day to mental clarity. My  fasting glucose is now 80mg/dL and goes into the 70s three hours post meals. My only problem is that period has completely stopped since going keto. I don’t restrict calories, only lift 4 times a week for around 45minutes and I don’t do any high intensity exercise or running. I also meditate daily and even use a red light to combat daily inflammation and stressors in life. To add to this I also am at a healthy weight for my height and have never had any weight problems all my life, I just had “metabolic syndrome” at a healthy weight. To take a deep dive I ran a ultrasound and found that I have a small cyst on my liver as well as a small amount of biliary sludge on my liver. I then proceeded to get a HIDA scan, a MRI of my abdomen, and pelvic area. Every came back normal so I then proceeded to run a hormone panel which then led me to get diagnosed with Hypothalamic Amenorrhea. I then decide that my HPA-axis most likely needs stimulation so I had a sweet potato consisting of 25grams of carbs with ground beef for lunch one day. The problem is after the meal I began having to urinate around every 15 to twenty minutes for the next two hours. I then proceeded to feel very jittery and anxious quickly following the meal. This led me to have a crash later in the day and I had to have a snack as I became profusely famished. I have never had to snack before I I eat a three large meals a day filled with whole keto foods and plenty of protein. I believe I still have insulin resistance but I want to be able to transition to a low carb style diet in order to stimulate my LH, HPA-axis, thyroid, and increase my estrogen levels in order to menstruate to protect my body from osteoporosis and other side effects of amenorrhea. My question is what route should I take in order to become fertile and is it possible to never reverse insulin resistance but just to put it in remission? https://robbwolf.com/2014/03/21/carb-reloading/ 3. Hey Ya'll it's time to "take down the Girl scout cookie army" [22:58] Joshua says: Dear Healthy Rebellion, Ok guys- I've been crazy Keto, Carnivore, low carb high fat for 9 years now.  I follow Paul Saladino, HPO with Shawn Baker, Brett Scher, Gary Fettke, Diana Rodgers, Mark Sisson, Taubes, Teicholz,  etc... You get it.  I'm on the scene.  My wife has RA and together we have gotten her health and wellness in check due to the above crowd and amazing people like you!  I am grateful to the low carb and similar communities.  I have personally gone from a 6'1", 190lb competitive cyclist to a lean mean 169lb very competitive cyclist in Colorado.  I also use LMNT and love it!!!  I spent a decade(well my whole life)  not understanding salt, electrolyte etc... what a great product man!  I love it.  I use S-caps and similar stuff and LMNT is by far the best! Anyhow- the "tone" of your podcast is such that I think YOU are crew to call out and take down the girl scout community or at least call them out.  A quick search yields that girl scout sell 200 million boxes of cookies each year!  WTFucking FUCK!  Will you do an episode and take this on? Sincerely, Josh T American millennials' mental and physical health is on the decline — and they're on track to die faster than Gen X, a new report says   4. Diabetes- all of the iterations and different ways to treat them [35:50] Jason says: Well first off, like everyone, thank you for all you do and provide! I've been following you for several years and really appreciate your approach to health and trying to be the healthiest version  of ourselves and also being open-minded and not super dogmatic. Which leads me to my question...As a health care provider I am always trying to learn new approaches and stay open to ideas on health outside of my normal. As a result I recently listened to a podcast on a plant-based podcast by Cyrus Khambatta and Robby Barbaro about diabetes and the mitigation and reversal using high carb-low fat/protein. Some of the things made sense to me but is also contrary to what I learned and what I hear most people talk about. I am wondering if you have heard or read anything by them and have thoughts on their biochemistry reasoning and/or how they are reportedly "fixing" diabetes by prescribing a high carb approach? Thank you again and keep up the good work https://carnivoremd.com/carnivore-vs-fruitarians-a-friendly-debate-with-robby-and-cyrus-from-mastering-diabetes/ 5. How are you defining "metabolic health condition?" [41:32] yankeerootssoutherner says: Robb, i saw your instagram story where you mentioned that people with an existing metabolic health condition have worse outcomes when it comes to covid-19. How are you defining metabolic health condition? Hyperinsulinemia: A unifying theory of chronic disease? Hyperinsulinemic diseases of civilization: more than just Syndrome X. Got a question for us? Submit your questions for the podcast here

Dr Greg Emerson discusses the incredible benefits of melatonin through its effects on our mitochondria, blood sugar and cancer risk reduction. He discusses the recent research showing that there is a problem if high levels occur with eating, reinforcing the wisdom of the circadian rhythm eating plan. He also interviews chiropractor, Dr Todd Lizon about the benefits of photobiomodulation and saunas wth red lights. https://www.cell.com/cell-metabolism/fulltext/S1550-4131%2816%2930160-7

Well, I am changing up the topic this week and heading over to diet and lifestyle topic. This new study proves that time restricted eating or Intermittent Fasting help you lose weight and has a lot of other benefits. If you have diabetes or know someone who does join me for today’s episodeHere is the link to the study: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30611-4Take the time to read it or go over to one of my favorite doctor pages for a translated version for us normal people to understand. https://www.dietdoctor.com/time-restricted-eating-hits-the-main-stageIntermittentFasting #WeightLoss #beatdiabetesBe sure to comment or send me an email at beverly@commandingyourlife. Ask me a question and let’s see what my opinion brings out. Upcoming classes and webinars can be found at http://tinyurl.com/ThinkRich2019Join me as I discuss important aspects of our beliefs and how they affect our lives.Royalty Free Use on podcast. See below for more information Windswept by Kevin MacLeod

In Episode 83 a very good friend of mine, Drew Harrisberg, returns to the show to talk about hidden agendas in science and the media with specific reference to a few somewhat dangerous trends we have noticed. In this rather fluid exchange Drew and I cover everything from the manipulation of science to produce favourable outcomes to confusing and oversimplified messages from people of influence on social media.Specifically we cover:How Drew's transition to a plant based diet has played out since Episode 62Dr Mark Hyman's confusing promotion of an extremely conflicted study on the "reversal of diabetes"Sarah Wilson's claims about methane and the impact of animal agriculture on climate changeWhy the "If It Fits Your Macros" & "Calorie Deficit" ideologies are an oversimplification and how it is possible to actually look and feel good at the same time (It's not one of the other)Good and bad foods - have we become too soft?The stigma associated with different types of Diabetes and associated sensitivity with regards to using 'diabetes' as an umbrella term.and much moreI hope you found this to be an interesting episode - I certainly did. Literally a conversation Drew and I would have in private. An unscripted exchange with no holding back. As I allude to throughout in conversation I think it’s important to note that just because I may hold a differing opinion to someone that doesn’t mean I dislike them or want conflict. I am open to sitting down with any of the people mentioned, or others, to further discuss these ideas and flesh them out with the best available science we have. If we want to expand our minds we need to take these conversations to places where they are a little uncomfortable and I think we got there in this episode - I look forward to doing it in the future and hopefully having some of these proponents of diets like the Ketogenic, If It Fits Your Macros or the Carnivore Diet on the show. I realise some of you may be thinking don’t give them the platform but in a controlled manner, if they do not have the fundamental science to support their argument, which I certainly havent been able to find, then ultimately all I see happening is an agenda revealing itself.RESOURCES/REFERENCES:For more information on the October 4-10th Plant Proof X Journey Retreat please visit hereThe retreats are an incredible week - a mix of exercise, connecting with like minded people, guest speakers, cooking demonstrations, delicious plant based meals and snacks, massages and plenty of down time to relax by the pool or explore the local area.Studies on plant based nutrition and diabetes management or risk:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682911/https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2738784https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560078/https://www.ncbi.nlm.nih.gov/pubmed/19339401https://www.ncbi.nlm.nih.gov/pubmed/29948369https://www.ncbi.nlm.nih.gov/pubmed/16873779https://www.mdpi.com/2072-6643/10/2/189Dr Michelle McMacken & Shivam Joshi's response to the Hallberg article that Mark Hyman spoke about:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682911/The highly conflicted Sarah Hallberg clinical study that was promoted by Dr Mark Hyman:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520897/Hallberg conflict of interests:"S.J.H. is an employee and shareholder of Virta Health, a for-profit company that provides remote diabetes care using a low-carbohydrate nutrition intervention, and serves as an advisor for Atkins Corp. V.M.G. has no conflicts of interest to declare. T.L.H. is an employee of Virta Health. S.J.A. is an employee and shareholder of Virta Health."Isocaloric high carb versus Ketogenic diet study:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962163/Truth about the Ketogenic Diet Blog:https://plantproof.com/the-truth-about-the-ketogenic-diet/Climate Change Blog:https://plantproof.com/animal-vs-plant-agriculture-in-the-era-of-climate-change/Interestingly Sarah Wilson has removed her blog so the link in my article to her website now results in a 404 page error. However, I downloaded the entire article and had already screenshot the bit about being supported by the animal industry which you can see in the blog. Deleted or not, the blog existed for 6+ years and based on the fact vigorous science doesn't support her opinion, and she has vested interests in animal agriculture, I believe the public were being grossly misled.If It Fits Your Macros Study by Kevin Hall on an Processed versus Unprocessed Diet with the same Macronutrients, fibre, sugar and sodium:https://www.cell.com/cell-metabolism/pdf/S1550-4131(19)30248-7.pdfShould Vegans Worry about Choline & brain health blog:https://plantproof.com/should-vegans-be-worried-about-choline-deficiency-and-their-brain-health/Drew Harrisberg's previous episodes on the Plant Proof Podcast:Episode 62Simon HillCreator of Plantproof.com - your FREE resource for plant based nutrition informationIf you want to receive FREE nutritional information to your inbox subscribe to the Plant Proof NewsletterBook coming out 2020 with Penguin (all proceeds being donated to charity)

Show Notes Jeff: Welcome back to EMplify the podcast corollary to EB Medicine’s Emergency Medicine Practice. I’m Jeff Nusbaum and I’m back with Nachi Gupta for the 30th episode of EMplify and the first Post-Ponte Vedra Episode of 2019. I hope everybody enjoyed a fantastic conference. This month, we are sticking in the abdomen for another round of evidence-based medicine, focusing on Emergency Department Management of Patients With Complications of Bariatric Surgery. Nachi: As the obesity epidemic continues to worsen in America, bariatric procedures are becoming more and more common, and this population is one that you will need to be comfortable seeing. Jeff: Thankfully, this month’s author, Dr. Ogunniyi, associate residency director at Harbor-UCLA, is here to help with this month’s evidence-based article. Nachi: And don’t forget Dr. Li of NYU and Dr. Luber of McGovern Medical School, who both played a roll by peer reviewing this article. So let’s dive in, starting with some background. Starting off with some real basics, obesity is defined as a BMI of greater than 30. Jeff: Oh man, already starting with the personal assaults, I see how this is gonna go… Show More v Nachi: Nah! Just some definitions, nothing personal! Jeff: Whatever, back to the article… Obesity is associated with an increased risk of hypertension, hyperlipidemia, and diabetes. Rising levels of obesity and associated co-morbidities also lead to an increase in bariatric procedures, and thereby ED visits! Nachi: One study found a 30-day ED utilization rate of 11% for those undergoing bariatric surgery with an admission rate of 5%. Another study found a 1-year post Roux-en-y ED visit rate of 31% and yet another found that 25% of these patients will require admission within 2 years of surgery. Jeff: Well that’s kind worrisome. Nachi: It sure is, but maybe even more worrisome is the rising prevalence of obesity. While it was < 15% in 1990, by 2016 it reached 40%. That’s almost half of the population. Additionally, back in 2010, it was estimated that 6.6% of the US population had a BMI> 40 – approximately 15.5 million adults!! Jeff: Admittedly, the US numbers look awful, and honestly are awful, but this is a global problem. From the 80’s to 2008, the worldwide prevalence of obesity nearly doubled! Nachi: Luckily, bariatric surgical procedures were invented and honed to the point that they have really shown measurable achievements in sustained weight loss. Along with treating obesity, these procedures have also resulted in an improvement in associated comorbidities like hypertension, diabetes, NAFLD, and dyslipidemia. Jeff: A 2014 study even showed an up to 80% reduction in the likelihood of developing DM2 postoperatively at the 7-year mark. Nachi: Taken all together, the rising rates of obesity and the rising success and availability of bariatric procedures has led to an increased number of bariatric procedures, with 228,000 performed in the US in 2017. Jeff: And while it’s not exactly core EM, we’re going to briefly discuss indications for bariatric surgery, as this is something we don’t often review even in academic training programs. Nachi: According to joint guidelines from the American Society for Metabolic and Bariatric Surgery, the American Association of Clinical Endocrinologists, and The Obesity Society, there are three groups that meet indications for bariatric surgery. The first is patients with a BMI greater than or equal to 40 without coexisting medical problems. The second is patients with a BMI greater than or equal to 35 with at least one obesity related comorbidity such as hypertension, hyperlipidemia, or obstructive sleep apnea. And finally, the third is patient with a BMI of 30-35 with DM or metabolic syndrome though current evidence is limited for this group. Jeff: Based on the obesity numbers, we just cited – it seems like a TON of people should be eligible for these procedures. Which again reiterates why this is such an important topic for us as EM clinicians to be well-versed in. Nachi: As far as types of procedures go – while there are many, there are 3 major ones being done in the US and these are the lap sleeve gastrectomy, Roux-en-Y gastric bypass, and lap adjustable gastric banding. In 2017, these were performed 60%, 18%, and 3% of the time. Jeff: And sadly, no two procedures were created alike and you must familiarize yourself with not only the procedure but also its associated complications. Nachi: So we have a lot to cover! overall, these surgeries are relatively safe with one 2014 review publishing a 10-17% overall complication rate and a perioperative 30 day mortality of less than 1%. Jeff: Before we get into the ED specific treatment guidelines, I think it’s worth discussing the procedures in more detail first. Understanding the surgeries will make understanding the workup, treatment, and disposition in the ED much easier. Nachi: Bariatric procedures can be classified as either restrictive or malabsorptive, with restrictive procedures essentially limiting intake and malabsorptive procedures limiting nutrient absorption. Not surprisingly, combined restrictive and malabsorptive procedures like the Roux-en-y gastric bypass tend to be the most effective. Jeff: Do note, however that 2013 guidelines do not recommend one procedure over another and leave that decision up to local surgical expertise, patient specific risk factors, and treatment goals. Nachi: That’s certainly an important point for the candidate patient. Let’s start by discussing the lap gastric sleeve. In this restrictive procedure, 80% of the greater curvature of the stomach is excised producing early satiety and weight loss from decreased caloric intake. This has been shown to have both low mortality and a low overall rate of complications. Jeff: Next we have the lap adjustable gastric band. This is also a restrictive procedure in which a plastic band is placed laparoscopically around the fundus leaving behind a small pouch that can change in size as the reservoir is inflated and deflated percutaneously. Nachi: Unfortunately this procedure is associated with a relatively high re-operation rate – one study found 20% of patients required removal or revision. Jeff: Even more shockingly, some series showed a 52% repeat operation rate. Nachi: 20-50% chance of removal, revision, or other cause for return to ER - those are some high numbers. Finally, there is the roux-en-y gastric bypass. As we mentioned previously this is both a restrictive and a malabsorptive procedure. In this procedure, the duodenum is separated from the proximal jejunum, and the jejunum is connected to a small gastric pouch. Food therefore transits from a small stomach to the small bowel. This leads to decreased caloric intake and decreased digestion and absorption. Jeff: Those are the main 3 procedures to know about. For the sake of completeness, just be aware that there is also the biliopancreatic diversion with or without a duodenal switch, as well as a vertical banded gastroplasty. The biliopancreatic diversion is used infrequently but is one of the most effective procedure in treating diabetes, though it does have an increased risk of complications. Expect to see this mostly in those with BMIs over 50. Nachi: Now that you have a sense of the procedures, let’s talk complications, both general and specific. Jeff: Of course, it should go without saying that this population is susceptive to all the typical post-operative complications such as venous thromboembolic disease, atelectasis, pneumonia, UTIs, and wound complications. Nachi: Because of their typical comorbidities, CAD and PE are still the leading causes of mortality, especially within the perioperative period. Jeff: Also, be on the lookout for self-harm emergencies as patients with known psychiatric disorders are at increased risk following bariatric surgery. Nachi: Surgical complications are wide ranging and can be grouped into early and late complications. More on this later… Jeff: Nutritional deficiencies are common enough to warrant pre and postoperative screening. Thiamine deficiency is one of the most common deficiencies. This can manifest within 1-3 months of surgery as beriberi or later as Wernicke encephalopathy. Symptoms of beriberi include peripheral neuropathy, ataxia, muscle weakness, high-output heart failure, LE edema, and respiratory distress. Nachi: All of that being said, each specific procedure has it’s own unique set of complications that we should discuss. Let’s start with the sleeve gastrectomy. Jeff: Early complications of sleeve gastrectomy include staple-line leaks, strictures, and hemorrhage. Leakage from the staple line typically presents within the first week, but can present up to 35 days, usually with fevers, tachycardia, abdominal pain, nausea, vomiting sepsis, or peritonitis. This is one of the most serious and dreaded early complications and represents an important cause of morbidity with an incidence of 3-7%. Nachi: Strictures commonly occur at the incisura angularis of the remnant stomach and are usually due to ischemia, leaks, or twisting of the gastric pouch. Patients with strictures usually have n/v, reflux, and intolerance to oral intake. Jeff: Hemorrhage occurs due to erosions at the staple line, resulting in peritonitis, hematemesis, or melena. Nachi: Late complications of sleeve gastrectomies include reflux, which occurs in up to 25% of patients, and strictures, which lead to epigastric discomfort, nausea, and dysphagia. Jeff: I’m getting reflux and massive heartburn just thinking about all of these complications, or the tacos i just ate…. Next we have the Roux-en-Y bypass. Nachi: Early complications of the Roux-en-Y Gastric Bypass include anastomotic or staple line leaks, hemorrhage, early postoperative obstruction, and dumping syndrome. Jeff: Leak incidence ranges from 1-6%, usually occurring at the gastro-jejunostomy site. Patients typically present within the first 10 days with abdominal pain, nausea, vomiting, and the feeling of impending doom. Some may present with isolated tachycardia while others may present with profound sepsis – tachycardia, hypotension, and fever. Nachi: Similar to the sleeve, hemorrhage can occur both intraperitoneally or intraluminally. This may lead to hematemesis or melena depending on the location of bleeding. Jeff: Early obstructions usually occur at either the gastro-jejunal or jejuno-jejunal junction. Depending on the location, patients typically present either within 2 days or in the first few weeks in the case of the gastro-jejunal site. Nachi: If the obstruction occurs in the jejuno-jejunostomy site, this can cause subsequent dilatation of the excluded stomach and lead to perforation, which portends a very poor prognosis. Jeff: Next, we have dumping syndrome. This has been seen in up to 50% of Roux-en-Y patients. Nachi: Early dumping occurs within 10-30 minutes after ingestion. As food rapidly empties from the stomach, this leads to distention and increased contractility, leading to nausea, abdominal pain, bloating, and diarrhea. This usually resolves within 7-12 weeks. Jeff: Moving on to late complications of the roux-en y - first we have marginal ulcers. Peptic ulcer disease and diabetes are risk factors and tobacco use and NSAIDs appear to increase your risk. In the worse case, they present with hematemesis or melena. Nachi: Internal hernias, intussusception, and SBOs are also seen after Roux-en-y gastric bypass. Patients with internal hernias usually present late in the postoperative period following significant weight loss. Jeff: Most studies cite a rate of 1-3% for internal hernias, with mortality up to 50% if there is strangulation. Nachi: And unfortunately for us on the front lines, diagnosis can be challenging. Presenting symptoms may be vague and CT imaging may be negative when patients are pain free, thus laparoscopy may be needed to definitively exclude an internal hernia. Jeff: Strictures may occur both during the early and late period. Most are minor, but significant strictures may result in obstruction. Nachi: Trocar site hernias and ventral hernias are also late complications, usually found after significant weight loss. Jeff: Cholelithiasis is another very common complication of bypass surgery, occurring in up to one third of patients, usually occurring during a peak incidence period between 6-18 months. Nachi: For this reason, the current recommendation is that patients undergoing bypass be placed on ursodeoxycholic acid for 6 months preventatively. Jeff: Some even go as far as to recommend prophylactic cholecystectomy to prevent complications, but as of 2013, the recommendation was only ‘to consider’ it. Nachi: Nutritional deficiencies are also common complications. Vitamin D, B12, Calcium, foate, iron, and thiamine deficiencies are all well documented complications. Patients typically take vitamins postoperatively to prevent such complications. Jeff: And next we have late dumping syndrome, which is far more rare than the last two complications. In late dumping syndrome, 1-3 hours after a meal, patients suffer hypoglycemia from excessive insulin release following the food bolus entering the GI tract. Symptoms are those typical of hypoglycemia. Nachi: Lastly, let’s talk about complications of lap adjustable gastric band surgery. In the early post op period, you can have esophageal and gastric perforations, which typically occur during balloon placement. Patients present with abd pain, n/v, and peritonitis. These patients often require emergent operative intervention. Jeff: The band can also be overtightened resulting in distention of the proximal gastric pouch. Presenting symptoms include abd pain with food and liquid intolerance and vomiting. Symptoms resolves once the balloon is deflated. The band can also slip, allowing the stomach to move upward and within the band. This occurs in up to 22% of patients and can cause strangulation. Presentation is similar to bowel ischemia. Nachi: Later complications include port site infections due to repeated port access. The infection can spread into connector tubing and the peritoneal cavity causing systemic symptoms. Definitely start antibiotics and touch base with the bariatric surgeon. Jeff: The connector can also dislodge or rupture with time. This can present as an arrest in weight loss. It’s diagnosed by contrast injection into the port. Of note, this complication is less common due to changes in the technique used. Nachi: Much like early band slippage and prolapse, patients can also experience late band slippage and prolapse after weeks or months. In extreme cases, the patients can again have strangulation and symptoms of bowel ischemia. More mild cases will present with arrest in weight loss, reflux, and n/v. Jeff: The band can also erode and migrate into the stomach cavity. If this occurs, it usually happens within 2 years of the initial procedure with an incidence of 4-11%. Presenting symptoms here include epigastric pain, bleeding, and infections. You’ll want to obtain emergent imaging if you are concerned. Nachi: And lastly there are two rare complications worth mentioning from any gastric bypass surgery. These are nephrolithiasis, possibly due to increased urinary oxalate excretion or hypocitraturia, and rhabdomyloysis. Jeff: That was a ton of information but certainly valuable as most EM clinicians, even ones in practice for decades, are unlikely to have that depth of knowledge on bariatric surgery. Nachi: And truthfully these patients are complicated. Aside from the pathologies we just discussed, you also have to still bear in mind other abdominal conditions unrelated to their surgery like appendicitis, diverticulitis, pyelo, colitis, hepatitis, pancreatitis, mesenteric ischemia, and GI bleeds. Jeff: Moving on to my favorite - prehospital care - as always, ABCs first. Consider IV access and early IV fluids in those at risk for dehydration and intra-abdominal infections. In terms of destination, if it’s feasible and the patient is stable consider transport directly to the nearest bariatric center - early efforts up front will really expedite patient care. Nachi: Once in the ED, you will want to continue initial stabilization. Special considerations for the airway include a concern for a difficult airway due to body habitus. Make sure to position appropriately and preoxygenate the patients if time allows. Keep the patient upright for as long as possible as they may desaturate quickly when flat. Jeff: We both routinely raise the head of the bed for all of our intubations. This is ever more important for your obese patients to help maximize your chance of first pass success without significant desaturation. Nachi: And though I’m sure we all remember this from residency, it’s worth repeating: tidal volume settings on the ventilator should be based on ideal body weight, not actual body weight. At 6 to 8 mL/kg. Jeff: Tachycardic patients should make you concerned for hypovolemia 2/2 dehydration, sepsis, leaks, and blood loss. Consider performing a RUSH exam (that is rapid ultrasound for shock and hypotension) to identify the cause. A HR > 120 with abdominal pain should make you concerned enough to discuss urgent ex-lap with the surgeon to evaluate for the post op complications we discussed earlier. Nachi: If possible, obtain a view of the IVC also while doing your ultrasound to assess for volume status. But bear in mind that ultrasound will undoubtedly be more difficult if the patient has a large body habitus, so don’t be disappointed if you’re not getting the best views. Jeff: Resuscitation should be aimed at early fluid replacement with IV crystalloids for hypovolemic patients and packed RBC transfusions for patients presumed to be unstable from hemorrhage. No real surprises there for our listeners. Nachi: Once stabilized, gather a thorough history. In addition to the usual questions, ask about po intolerance, early satiety, hematemesis, and hematochezia. Definitely also gather a thorough surgical history including name of procedure, date, known complications post op, and name of the surgeon. Jeff: You might also run into “medical tourism” or global bariatric care. Patients are traveling overseas to get their bariatric care more and more frequently. Accreditation and oversight is variable in different countries and there isn’t a worldwide standard of care. Just an important phenomenon to be aware of in this population. Nachi: On physical exam, be sure to look directly at the belly, making note of any infections especially near a port-site. Given the reorganized anatomy and extent of soft tissue in obese patients, don’t be reassured by a benign exam. Something awful may be happening deeper. Jeff: This naturally brings us into diagnostic testing. Not surprisingly, labs will be helpful in these patients. Make sure to check abdominal labs and a lipase. Abnormal LFTs or lipase may indicate obstruction of the biliopancreatic limb in bypass patients. Nachi: A lactic acid level will help in suspected cases of hypoperfusion from sepsis or bowel ischemia. Jeff: And as we mentioned earlier, these patients are often at risk for ACS given their comorbidities. Be sure to check a troponin if you suspect cardiac ischemia. Nachi: If concerned for sepsis, draw blood cultures, and if concerned for hemorrhage, be sure to send a type and screen. Urinalysis and urine culture should be considered especially for early post op patients, symptomatic patients, or those with GU complaints. Jeff: And don’t forget the urine pregnancy test for women of childbearing age, especially prior to imaging. Nachi: Check an EKG immediately after arrival for any patient that may be concerning for ACS. A normal ekg of course does not rule out a cardiac cause of their presentation. Jeff: As for imaging, plain radiographs certainly play a role here. For patients with respiratory complaints, check a CXR. In the early postoperative period, there is increased risk for pneumonia. Nachi: Unstable patients with abdominal pain will benefit from an emergent abdominal series, which may show free air under the diaphragm, pneumatosis, air-fluid levels, or even dilated loops of bowel. Jeff: Of course don’t forget that intra abd air may be seen after laparoscopic procedures depending on how recently the operation was performed. Nachi: Plain x-ray can also help diagnose malpositioned or slipped gastric bands. But a negative study doesn’t rule out any of these pathologies definitively, given the generally limited sensitivity and specificity of x-ray. Jeff: You might also consider an upper GI series. Emergent uses include diagnosis of slipped or prolapsed gastric bands as well as gastric or esophageal perforations. Urgent indications include diagnosis of strictures. These can also diagnose gastric band erosions and help identify staple-line or anastomotic leaks in stable patients. Nachi: However, upper GI series might not be easy to obtain in the ED, so it’s often not the first test performed. Jeff: This brings us to the workhorse for diagnostic evaluation. The CT. Depending on suspected pathology, oral and/or IV contrast will be helpful. Oral contrast can help identify gastric band erosions, staple-line leaks, and anastomotic leaks. Leaks can be identified in up 86% of cases with oral contrast. Nachi: CT will also help diagnose internal hernias. You might see the swirl sign on CT, which represents swirling of the mesenteric vessels. This is highly predictive of an internal hernia, with a sensitivity of 78-100% and specificity of 80-90% according to at least two studies. Jeff: While CT is extremely helpful in making this diagnosis, note that it may be falsely negative for internal hernias. A retrospective review showed a sensitivity of 76% and a specificity of 60%. It also showed that 22% of patients with an internal hernia on surgical exploration had a negative CT in the ED. Another study found a false negative rate of 32%. What does all this mean? It likely means that a negative study may still necessitate diagnostic laparoscopy to rule out an internal hernia. Nachi: While talking about CT, we should definitely mention CTA for concern of pulmonary embolism. In order to limit contrast exposure, you might consider doing a CTA chest and CT of the abdomen simultaneously. Jeff: Next up is ultrasound. Ultrasound is still the first-line imaging modality for assessing the gallbladder and for biliary tract disease. And as we mentioned previously, ultrasound should be considered for your RUSH exam and for assessing the IVC. Nachi: We also should discuss endoscopy, which is the test of choice for diagnosing gastric band erosions. Endoscopy is also useful for evaluating marginal ulcers, strictures, leaks, and GI bleeds. Endoscopy additionally can be therapeutic for patients. Jeff: When treating these patients, attempt to contact the bariatric surgeon for guidance as needed. This shouldn’t delay imaging however. Nachi: For septic patients, make sure your choice of antibiotics covers intra-abdominal gram-negative and anaerobic organisms. Port-site infections require gram-positive coverage to cover skin flora. Additionally, give IV fluids, blood products, and antiemetics as appropriate. Jeff: Alright, so this month, we also have 2 special populations to discuss. First up, the kids. Nachi: Recent estimates from 2015-2016 put the prevalence of obesity of those 2 years old to 19 years old at about 19%. As obese children are at higher risk for comorbidities later in life and bariatric surgery remains one of the best modalities for sustained weight loss, these surgical procedures are also being done in children. Jeff: Criteria for bariatric surgery in the adolescent population is similar to that of adults and includes a BMI of 35 and major comorbidities (like diabetes or moderate to severe sleep apnea) or patients with a BMI 40 with other comorbidities associated with long term risks like hypertension, dyslipidemia, insulin resistance and impaired quality of life. Nachi: Despite many adolescents meeting criteria, they should be referred with caution as the long term effects are unclear and the adolescent experience is still in its infancy with few pediatric specific programs. Jeff: Still, the complication rate is low - about 2.3% with generally good clinical outcomes including improved quality of life and reducing or staving off comorbidities. Nachi: Women of childbearing age are the next special population. They are at particular risk because of the unique caloric and nutrient needs of a pregnant mother. Jeff: Pregnant women who have had bariatric surgery have an increased risk of perinatal complications including prematurity, small for gestational age status, NICU admission and low Apgar scores. However, these risks come with benefits as other studies have shown reduced incidence of pre-eclampsia, large for gestational age neonates, and gestational diabetes. Nachi: 2013 guidelines from various organizations recommend avoiding becoming pregnant for at least 12-18 months postoperatively, with ACOG recommending a minimum of 2 years. Bariatric surgery patients who do become pregnant require serial monitoring for fetal growth and higher doses of supplemental folate. Jeff: We also have 2 pretty cool cutting edge techniques to mention this month before getting to disposition. Nachi: Though these are certainly not going to be done in the ED, you should be aware of two new techniques. Recently, the FDA approved 3 new endoscopic gastric balloon procedures in which a balloon is inflated in the stomach as a means of simulating a restrictive procedure. Complications include perforation, ulceration, GI bleeding, and migration with obstruction. As of now, they are only approved as a temporary modality for up to 6 months. Jeff: And we also have the AspireAssist siphon, which was approved in 2016. With the siphon, a g tube is placed in the stomach, and then ⅓ of the stomach contents is drained 20 minutes after meals, thus limiting overall digested intake. Nachi: Pretty cool stuff... Jeff: Yup - In terms of disposition, decisions should often be made in conjunction with the bariatric surgical team. Urgent and occasionally emergent surgery is required for those with hemodynamic instability, anastomotic or staple line leaks, SBO, acute band slippage with dilatation of the gastric pouch, tight gastric bands, and infected port sites with concurrent intra abdominal infections. Nachi: And while general surgeons should be well-versed in these complications should the patient require an emergent surgery, it is often best to stabilize and consider transfer to your local bariatric specialty facility. Jeff: In addition to the need for admission for surgical procedures, admission should also be considered in those with dehydration and electrolyte disturbances, those with persistent vomiting, those with GI bleeding requiring transfusions, those with acute cholecystitis or choledococholithiasis, and those with malnutrition. Nachi: Finally, patients with chronic strictures, marginal ulcers, asymptomatic trocar or ventral hernias, and stable gastric band erosions can usually be safely discharged after an appropriate conversation with the patient’s bariatric surgeon. Jeff: Definitely a great time to do some joint decision making with the patient and their surgeon. Nachi: Exactly. Let’s close out with some Key points and clinical pearls. Jeff: Bariatric surgeries are being performed more frequently due to both their success in sustained weight loss and improvements in associated comorbidities. Nachi: There is an increased risk of postoperative myocardial infarction and pulmonary embolism after bariatric surgery. There is also an increased risk of self-harm emergencies after bariatric surgery, mostly in patients with known psychiatric co-morbidities. Jeff: Nutritional deficiencies can occur following bariatric surgery, with thiamine deficiency being one of the most common. Look for signs of beriberi or even Wernicke encephalopathy. Nachi: Staple-line leaks are an important cause of postoperative morbidity. Patients often present with abdominal pain, vomiting, sepsis, and peritonitis. Jeff: Strictures can also present postoperatively and cause reflux, epigastric discomfort, and vomiting. Nachi: Intraperitoneal or intraluminal hemorrhage is a known complication of bariatric surgery and may present as peritonitis or with hematemesis and melena. Jeff: After significant weight loss, internal hernias with our without features of strangulation are a late complication. Nachi: Late dumping syndrome is a rare complication following Roux-en-Y bypass occurring months to years postoperatively. It presents with hypoglycemia due to excessive insulin release. Jeff: Esophageal or gastric perforation are early complications of adjustable gastric band surgery. These patients require emergent surgical intervention. Nachi: Overtightening of the gastric band results in food and liquid intolerance. This resolves once the balloon is deflated. Jeff: Late complications of gastric band surgery include port-site infections, connector tubing dislodgement or rupture, band slippage or prolapse, and band erosion with intragastric migration. Nachi: Given the myriad of possible bariatric surgeries, emergency clinicians should be cognizant of procedure-specific complications. Jeff: Consider obtaining a lactic acid level for cases of suspected bowel ischemia or sepsis. Nachi: Endoscopy is the best method for diagnosing and treating gastric band erosions. Jeff: Septic patients should be treated with antibiotics that cover gram-negative and anaerobic organisms. Suspected port site or wound infections require gram positive coverage. Nachi: Pregnant patients who previously had bariatric surgery are at risk for complications from their prior surgery as well as pregnancy-related pathology. Jeff: A plain radiograph may be useful in unstable patients to evaluate for free air under the diaphragm, pneumatosis, air-fluid levels, or dilated loops of bowel. Nachi: CT of the abdomen and pelvis is the mainstay for evaluation. Oral and/or IV contrast should be considered depending on the suspected pathology. Jeff: Have a low threshold for emergent surgical consultation for ill-appearing, unstable, or peritonitic patients. Nachi: So that wraps up Episode 30! Jeff: As always, additional materials are available on our website for Emergency Medicine Practice subscribers. If you’re not a subscriber, consider joining today. You can find out more at ebmedicine.net/subscribe. Subscribers get in-depth articles on hundreds of emergency medicine topics, concise summaries of the articles, calculators and risk scores, and CME credit. You’ll also get enhanced access to the podcast, including any images and tables mentioned. PA’s and NP’s - make sure to use the code APP4 at checkout to save 50%. Nachi: And the address for this month’s cme credit is ebmedicine.net/E0719, so head over there to get your CME credit. As always, the [DING SOUND] you heard throughout the episode corresponds to the answers to the CME questions. Lastly, be sure to find us on iTunes and rate us or leave comments there. You can also email us directly at EMplify@ebmedicine.net with any comments or suggestions. Talk to you next month! Most Important References Altieri MS, Wright B, Peredo A, et al. Common weight loss procedures and their complications. Am J Emerg Med. 2018;36(3):475-479. (Review article) Colquitt JL, Pickett K, Loveman E, et al. Surgery for weight loss in adults. Cochrane Database Syst Rev. 2014(8):CD003641. (Cochrane review; 22 trials) Mechanick JI, Youdim A, Jones DB, et al. Clinical practice guidelines for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient—2013 update: cosponsored by American Association of Clinical Endocrinologists, The Obesity Society, and American Society for Metabolic & Bariatric Surgery. Obesity (Silver Spring). 2013;21 Suppl 1:S1-S27. (Society practice guidelines) Phillips BT, Shikora SA. The history of metabolic and bariatric surgery: development of standards for patient safety and efficacy. Metabolism. 2018;79:97-107. (Review article) Contival N, Menahem B, Gautier T, et al. Guiding the nonbariatric surgeon through complications of bariatric surgery. J Visc Surg. 2018;155(1):27-40. (Review article) Parrott J, Frank L, Rabena R, et al. American Society for Metabolic and Bariatric Surgery integrated health nutritional guidelines for the surgical weight loss patient, 2016 update: micronutrients. Surg Obes Relat Dis. 2017;13(5):727-741. (Society practice guidelines) Chousleb E, Chousleb A. Management of post-bariatric surgery emergencies. J Gastrointest Surg. 2017;21(11):1946-1953. (Review article) Goudsmedt F, Deylgat B, Coenegrachts K, et al. Internal hernia after laparoscopic Roux-en-Y gastric bypass: a correlation between radiological and operative findings. Obes Surg. 2015;25(4):622-627. (Retrospective review; 7328 patients) Michalsky M, Reichard K, Inge T, et al. ASMBS pediatric committee best practice guidelines. Surg Obes Relat Dis. 2012;8(1):1-7. (Society practice guidelines)

Kim shares the findings of a new nutrition study, as well as explores the topic of dieting. You can read the full nutrition study here: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30248-7

In this episode, I begin discussing some of the results from an influential paper published in the esteemed journal Cell speaking on fasting and a variety of different health markers - fascinating stuff! Study: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(15)00224-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1550413115002247%3Fshowall%3Dtrue YouTube: bit.ly/2JUjXVt Facebook: bit.ly/2PlIOaB Instagram: bit.ly/2OBFe7i Email List: bit.ly/2AXIzK6 Patreon: bit.ly/2OBBna0

A new small scale study of 20 adult volunteers is the first randomized controlled trial to examine the effects of processed foods.  Listen in this week as Dee explains the methodology of the study and what this means for your health. Link to Article Link to Research Study

Episode Summary:This episode discusses the concept of how the expression of our genes controls our destiny for good metabolic health and how to change that fortune in our favor. Topics mentioned are as follows:Introduction to genes and gene expressionThe expression of our genes can become brokenDr. Dan’s gene expression formula Episode References:For a review on the vast amount of genetic information the body: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705322/Offspring of overweight men more prone to obesity: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(15)00571-9Genes related to insulin in diabetics can be silenced and passed on: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3030456/Fearful memories carry through at least two generations in mice: https://www.nature.com/news/fearful-memories-haunt-mouse-descendants-1.14272For a review of natural products used as pharmaceuticals, see: https://www.ncbi.nlm.nih.gov/pubmed/26852623

Discussed in this episode are the following issues related to the health crisis sweeping the earth like a noxious plague:What does it mean to be healthy?The epic breakdown of human healthThe name given for this breakdown of healthDefinition of metabolic syndrome3 Maxims for optimum healthEpisode References:Definition health from a systems biology standpoint: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30092-XLeading causes of death in the US: https://www.cdc.gov/nchs/fastats/leading-causes-of-death.htmObesity rates in the US: https://www.cdc.gov/obesity/data/adult.htmlPrevalence of diabetes in the US: http://www.diabetes.org/diabetes-basics/statistics/Heart diseases statistics in the US: https://www.cdc.gov/heartdisease/facts.htmCriteria for Metabolic Syndrome: https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.109.192644?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3DpubmedSelected metabolic syndrome rates worldwide: https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-017-4041-1 Sleep cleans the brain: http://science.sciencemag.org/content/342/6156/373Effect of stress on human health: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380124/pdf/dmj-36-207.pdf

WORKOUT OF THE WEEK: (00:14:10) Drugs in Triathlon. HOT PROPERTY INTERVIEW: SARA GROSS (00:29:00) Sara Gross, ex triathlete now Media Mogul, has set up a new media website “Live Feisty Media” aimed at empowering new perspectives and voices in triathlon & beyond. We talk about Sara’s new initiative plus her other interests which include the ‘Outspoken women in triathlon summit’ bringing together women’s voices to elevate women in triathlon. SID TALKS: (01:08:37) Sid’s in Tuscany and we talk IM Frankfurt. ONE STEP AHEAD: (01:43:30) Maximising cellular adaptation to endurance exercise and skeletal muscle.  LINKS: More about Sara Gross at  http://www.saragross.ca/ More about Live feisty Media at http://livefeisty.com/ and on Facebook at https://www.facebook.com/livefeistymedia/ More about Laura Siddall at https://laurasiddall.com/ Follow Laura on Facebook at https://www.facebook.com/LauraSiddallTriathlete/ One step Ahead article at https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30257-2 CONTACT US: Learn more about us at http://www.fitter.co.nz Like us on Facebook at http://www.facebook.com/fittercoaching for the latest news and information Mikki Williden can be found at https://www.facebook.com/mikkiwillidennutrition

WORKOUT OF THE WEEK: (00:17:04) Should we make our bikes lighter or more aero. HOT PROPERTY INTERVIEW: DOUGAL ALLAN (00:30:50) Bevan and Tim talk to Fitter coached athlete Dougal Allan about running mechanics and his recent decision to race Coast to Coast 2019. ONE STEP AHEAD: (01:09:02) Amino acids.   LINKS: More about Dougal Allan at https://www.dougalallan.com/ Follow Dougal on Facebook at https://www.facebook.com/DAendurance/ Ken Ballhause at Adaptive HP in Melbourne at https://www.adaptivehp.com/ Wattie Ink at https://www.wattieink.com/   51 Speed Shop at https://51-speedshop.com/ Dave Bowden at Speed Theory http://speedtheory.co.nz/ Marathon investigations at https://www.marathoninvestigation.com/ One Step Ahead articles at https://scholar.google.co.nz/scholar?as_ylo=2018&q=branched+chain+amino+acids+endurance&hl=en&as_sdt=0,5&as_vis=1#d=gs_qabs&p=&u=%23p%3DxgG5SUTT4PsJ and https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30257-2 CONTACT US: Learn more about us at http://www.fitter.co.nz Like us on Facebook at http://www.facebook.com/fittercoaching for the latest news and information Mikki Williden can be found at https://www.facebook.com/mikkiwillidennutrition

Dr. Peterson is an Assistant Professor in the Department of Nutrition Sciences at the University of Alabama at Birmingham. Listen as we talk about different fasting strategies, the big bang and the importance of our biological rhythms. Show notes: Dr. Peterson’s UAB Bio https://www.uab.edu/shp/nutrition/about-the-department/faculty-and-staff/primary-faculty/160-courtney-m-petersonProject Time Restricted-Feeding Blog Post http://blog.mycircadianclock.org/early-time-restricted-feeding-for-the-prevention-of-diabetes/ Dr. Peterson’s Coverage in the Washington Post https://www.washingtonpost.com/national/health-science/timing-your-meals-may-help-with-weight-loss-thats-what-it-seems-to-do-in-mice/2018/03/23/14672fc0-f718-11e7-a9e3-ab18ce41436a_story.html?noredirect=on&utm_term=.af64ab9e5818 Dr. Peterson’s Pilot Study of TRF in Prediabetes https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30253-5

Dr. Brendan Egan is an Associate Professor of Sport and  Exercise Physiology at Dublin City University who is well known for research that shows resistance training can improve strength, muscle mass, reduce falls in older people, and perhaps even extend lifespans. In addition to being a first-class researcher, Brendan is also a stand-out player in Ireland’s national sport, Gaelic football. His current research is exploring the synergy between nutrition and exercise interventions to optimize performance in athletes and the elderly. Current projects also involve protein hydrolysates in recovery and glycemic management; leucine and n-3 PUFAs in the elderly; and exogenous ketones and athletic performance. Links:  Brendan Egan’s faculty page:  https://dcu.academic.ie/live/!W_VALOCAL_DCU_PORTAL.PROFILE?WPBPRSN=1631629 Brendan Egan’s Researchgate profile https://www.researchgate.net/profile/Brendan_Egan2/contributions Brendan Egan’s TEDx talk: https://youtu.be/LkXwfTsqQgQ Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation https://www.sciencedirect.com/science/article/pii/S1550413112005037 Metabolism of ketone bodies during exercise and training: https://physoc.onlinelibrary.wiley.com/doi/epdf/10.1113/JP273185 Fueling performance: Ketones Enter the Mix: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30438-7 Does Strength-Promoting Exercise Confer Unique Health Benefits? https://academic.oup.com/aje/article-abstract/187/5/1102/4582884?redirectedFrom=fulltext Does Strength-Promoting Exercise Confer Unique Health Benefits? https://physoc.onlinelibrary.wiley.com/doi/full/10.1113/JP275938 Show notes: 2:46: Dawn opens by mentioning that Brendan was born in Detroit, and that his Irish father moved the family to Ireland when Brendan was 3 years old. Dawn asks if Brendan’s mother was American. 4:09: Dawn comments on how Brendan was very athletic as a child and played Gaelic football, which is Ireland’s national sport, and asks if he could explain how this game is played. 6:02: Ken, following up on the last question, asks what Brendan’s training is like for this sport, and how he manages to fit it into his busy schedule as a professor. 7:41: Dawn asks if it is true that even though Brendan’s best grades were in math and physics, he never considered a career in science while he was in high school. 8:37: Dawn mentions that Brendan ended up at the University of Limerick after graduating, asking what made him decide to attend Limerick as well as what prompted him to major in sports and exercise science. 9:46: Dawn asks about two people, Phil Jakeman and John Kirwan, who played a big role in shaping Brendan’s education at Limerick. 11:58: Dawn comments on how after completing his bachelor’s of science degree, Brendan went to work on his master’s, heading to the UK and attending Loughborough University where he graduated with distinction in sports exercise and nutrition. Dawn asks what made him decide to attend Loughborough, and what stood out about his time there. 13:33: Dawn mentions that Brendan returned to Ireland in 2004 to start his doctoral studies under the supervision of Dr. Donal J O'Gorman at Dublin City University. Dawn asks what that experience was like. 15:06: Ken asks what Brendan learned from his research with Dr. O’Gorman, which focused on skeletal muscle adaptation to exercise and, in particular, continuity between acute molecular responses to individual bouts of exercise and the adaptations in skeletal muscle induced by exercise training. 18:30: Dawn asks what took Brendan to Karolinska Institute in Stockholm. 19:51: Brendan talks about his work at Karolinska using animal intravenous cell systems, and his research into transcriptional regulation of skeletal muscle insulin resistance and type 2 diabetes utilizing small non-coding RNA’s. 23:39: Ken mentions that Brendan’s first faculty posit...

There is a hypothesis that insulin drives fat loss. Insulin is a hormone that is released when we eat carbohydrates and to a lesser degree when we eat protein. Insulin tells the cells to store fat and take in sugar.  Therefore, according to the theory, when we cut carbohydrates our body will use more fat regardless of total calories.  Today, I want to examine this hypothesis with some science and see if it hold up.    Here are the studies that I referred to:  https://www.ncbi.nlm.nih.gov/pubmed/27385608 https://www.cell.com/cell-metabolism/fulltext/S1550-4131(15)00350-2   General Links: Schedule a Consultation Discounted Life Insurance My Supplement Store  

In this edition, we hear about a new topical drug that has the ability to darken the skin, with David Fisher, from Cell Reports (00:00); how sense of smell may be tied to metabolism and weight control, with Andrew Dillin, from Cell Metabolism (12:08); and tips on how to make the most out of your next scientific conference, with Shawnna Buttery (19:15).

Hank recruits the fittest of the fit for his couch spaceship. ------------------------ Panelists: Michael Aranda: https://runnersconnect.net/iron-deficiency-in-runners/ Stefan Chin: http://bjsm.bmj.com/content/46/13/927 https://www.sciencedaily.com/releases/2017/01/170118151544.htm https://link.springer.com/article/10.1007%2Fs00125-012-2677-z https://academic.oup.com/aje/article/172/4/419/85345/Leisure-Time-Spent-Sitting-in-Relation-to-Total https://academic.oup.com/jnci/article/doi/10.1093/jnci/dju098/1008529/Television-Viewing-and-Time-Spent-Sedentary-in?_ga=1.42982689.527235840.1397574100 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960753/ http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0080000 https://www.ncbi.nlm.nih.gov/pubmed/19346988 https://academic.oup.com/ije/article/44/6/1909/2572591/Associations-of-sitting-behaviours-with-all-cause http://www.sciencedirect.com/science/article/pii/S0749379710004125 http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0070213 https://www.ncbi.nlm.nih.gov/pubmed/22374636?dopt=Abstract http://ajcn.nutrition.org/content/early/2013/06/26/ajcn.112.051763 Hank Green: https://www.scientificamerican.com/article/how-to-grow-stronger-without-lifting-weights/ Victoria Bongiorno: http://www.cell.com/cell-metabolism/fulltext/S1550-4131(12)00005-8 https://www.ncbi.nlm.nih.gov/pubmed/25864559 ------------------------ Holy F*****g Science is a Podcast about science that is not for kids in which four people get together to try and astound and amaze each other with the realities of our glorious universe. Secondary goal: To make each other laugh. Follow us on SoundCloud: https://soundcloud.com/holyfuckingscience iTunes: https://itunes.apple.com/us/podcast/hfs-podcast/id1200863480?mt=2 Google Play Music: https://play.google.com/music/listen#/ps/Iyvl42whhlhj4gs6ijctlwdodbm RSS: http://feeds.soundcloud.com/users/soundcloud:users:273239668/sounds.rss

On this week's holiday episode our News & Views segment starts at Krispy Kreme to see if we can extract any good take-aways from the recent class-action lawsuit filed against the chain. Then, it's on to a recent study about what happens when you don't feed your gut bacteria...what do they eat instead? The segment is rounded out with coverage of recent research on whole milk for kids and a new—somewhat strange–non-pharmaceutical weight-loss pill. The Moment of Paleo segment offers thoughts on restriction and upcoming holiday feasts. And After the Bell features a talk about life's invisible feast. Enjoy the show! Links for this episode:Latest in Paleo on Facebook — Leave a Comment About this Episode or Post a News LinkWhy & How to Support Latest in PaleoRecommended Food & ProductsRecommended Books & AudiobooksKrispy Kreme Lawsuit Claims Company Misled Over Doughnut FruitA Fruitless Suit?: Krispy Kreme Sued Over Fake Berry-Flavored Donuts - Law Street (TM)Kreme-filled lies — Doughnut company faces a Krispy $5M lawsuit - NY Daily NewsA Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility: CellHigh-fiber diet keeps gut microbes from eating the colon’s lining, protects against infection, animal study shows | University of Michigan Health SystemEating fiber keeps gut microbes from eating you - Medical News TodayEat Fiber: Whole Grains Prevent Gut Microbes From Eating Intestine Lining, Increasing Infection Risknew The Hungry Microbiome: why resistant starch is good for you - YouTubeWhich Foods to Eat: The Hungry MicrobiomeRelation between milk-fat percentage, vitamin D, and BMI z score in early childhoodDo we have it backward on giving kids low fat milk instead of whole? - Health - CBC NewsKids who drink whole milk slimmer than those who don'tUses for skim milk before it was marketed as a nonfat diet product: Hog slop and wool.A 6-Month Swallowable Balloon System Results In Sustainable Weight Loss At 1 Year: Results from A Prospective, Randomized Sham-Controlled Trial - Surgery for Obesity and Related DiseasesBalloon-in-a-Pill Helped Obese Patients Lose Weight: MedlinePlus Health NewsThis Weight Loss Pill Inflates a Balloon In Your Stomach | TIMEWeight-loss balloon helps shed twice the weight, research says - CNN.comWatch "Possibilities—life's invisible feast: Sarah Susanka at TEDxSanDiego" Video at TEDxTalksVisit PuraKai to shop for eco-friendly clothing and stand-up paddle boards. Be sure to use coupon code "latest in paleo" for 15% off all clothing purchases.

For years, scientists have known that someone who is thin could still end up with diabetes. Yet an obese person may be surprisingly healthy. Scott Summers, Ph.D., chair of nutrition and integrative physiology, and Bhagirath Chaurasia, Ph.D., assistant professor at the University of Utah College of Health explain their new research that points to an answer to that riddle: Accumulation of a toxic class of fat metabolites, known as ceramides, may make people more prone to type 2 diabetes. Their work was recently published online in Cell Metabolism; learn more here.

Joel Fuhrman, M.D. is our guest on today's show. We talk about fat, protein, longevity, what foods should be eaten daily, why nuts and seeds are important, why he doesn't recommend eating too much starch, and so much more. He's written several best sellers, including Eat to Live and most recently The End of Dieting. He's also appeared on several PBS specials, published research, and was once the number 3 pairs figure skater in the world. He calls his diet Nutritarian, with immense focus on nutrient density from whole foods. He doesn't fit neatly into any of the popular diet camps. This episode is information-dense, as Dr. Fuhrman answers my many questions with great detail. Enjoy the show! Links for this episode:This Episode on LatestInPaleo.comGet the Free Latest in Paleo Health TickerFood & Other RecommendationsBook RecommendationsSmart Nutrition, Superior Health. | DrFuhrman.comEat to Live Blog | DrFuhrman.comJoel Fuhrman, MD (@DrFuhrman) | TwitterDr. Fuhrman - YouTubeDefining the Nutritional and Metabolic Context of FGF21 Using the Geometric Framework: Cell MetabolismThis New Study Proves That Carbs Are Not Bad For You

Liam Bowler and Carrie Forrest join us to discuss News & Views. We start with three very interesting stories centering around genetics: anxiety's link to metabolic disorder; the 'fat gene' and weight loss; and the latest research on the 'thrifty gene hypothesis.' The Moment of Paleo segment furthers some of the themes discussed during the news segment and revolves around boxing ourselves into various narratives. After the Bell features Jennifer Douden, one of the inventors of CRISPR, a genome editing tool. Links for this episode:Get the Free Latest in Paleo Health News Ticker!This Episode at latestinpaleo.comLatest in Paleo on FacebookBook & Audiobook RecommendationsThe Body Awake by Liam Bowler + Dynamic Alignment Bodywork on iTunesDynamic Alignment Bodywork : Liam Bowler, LMP, BCSILiam Bowler, LMP, BCSI — Dynamic Alignment Bodywork - YouTubeCarrie on LivingCarrie Forrest, MPH (@carrieonliving) | TwitterCarrie on LivingCarrie Forrest, MPH Nutrition (@carrieonliving) • Instagram photos and videosMicroRNA Regulators of Anxiety and Metabolic Disorders: Trends in Molecular MedicineStudy reveals a biological link between stress and obesityWhy Anxiety Can Lead To Weight Gain: New StudyIsraeli researchers find first biological link between stress and obesity - Business & Innovation - Jerusalem PostFTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials | The BMJObesity gene no barrier to weight loss, study shows | Society | The GuardianFTO gene not an obesity life sentence: studySNPwatch: Gene Variant Linked to Obesity Affects Food Choices in ChildrenAnalysis of Positive Selection at Single Nucleotide Polymorphisms Associated with Body Mass Index Does Not Support the “Thrifty Gene” Hypothesis: Cell MetabolismObesity Might Not Have Evolved To Protect Us From Starvation | Popular ScienceHuman tendency for obesity not result of evolutionary adaption to survive famine | Genetic Literacy ProjectGood Posture Matters More Than You Think | Timi Gustafson, R.D.Ways to Avoid and Treat 'Tech Neck' - Story5 Exercises to Remedy "Tech Neck" - How to Treat and Prevent Neck PainVisit PuraKai to shop for eco-friendly clothing and stand-up paddle boards. Be sure to use coupon code "latest in paleo" for 15% off all clothing purchases.

On this episode, I discuss my recent 5-day fast: how it went, what I learned, and whether I'll be doing it again. In the News & Views segment, we discuss a CNN article about fasting and longevity as well as a NY Times article that indicates intermittent fasting is becoming more widely accepted. You'll learn about a 450-lb man who did not eat food for over a year and reduced his body to a normal size. In the Moment of Paleo, I offer some ideas about when less is more. And After the Bell features a Dr. Jason Fung presentation about fasting as an important health tool. Enjoy the show! Links for this episode:This Episode's HomepageLatest in Paleo on Facebook - News hunters and gatherers post your links here.Full List of Recommended Books & AudiobooksEat, Fast & Live Longer HD - Video DailymotionOccasional fasting could help you live longer - CNN.comPeriodic fasting may lead to longer, healthier lives - AOLFasting Diets Are Gaining Acceptance - The New York TimesDietary restriction improves repopulation but impairs lymphoid differentiation capacity of hematopoietic stem cells in early agingHere's how occasional fasting could actually be good for you - ScienceAlertThe up- and downside of caloric restriction for aging and healthAGINGADVICE.ORGFasting - Wikipedia, the free encyclopediaDaniel Fast - Wikipedia, the free encyclopediaFasting Chart - Beliefnet.comUsing Fasting for Natural Healing | AllAboutFastingFasting: health benefits and risks - Medical News TodayA Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan: Cell MetabolismA History of Modern Research into Fasting, Starvation, and Inanition - SpringerMedically Supervised Water-only Fasting in the Treatment of HypertensionThe Fasting AdvantageHarpersMagazine Fasting - CloudupFasting: health risks - Live Well - NHS ChoicesWhat no one talks about when they extol the benefits of fasting - VoxFive day 'fasting' diet slows down ageing and may add years to life - TelegraphThe three-day fast: Day Four | Josh MitteldorfLifeboat Foundation Bios: Dr. Joshua MitteldorfBursts of fasting may be key to longevity and health - The Columbia Chronicle: Health & TechCould a 5-Day Fasting Diet Prolong Your Life?Effect of diet and exercise on serum insulin, IGF-I, and IGFBP-1 levels and growth of LNCaP cells in vitro (United States) - SpringerA year without food › Dr Karl's Great Moments In Science (ABC Science)The Ancient Secret of Weight LossIs Fasting an Effective Therapy for Weight Loss? - Weight LossThe Aetiology of Obesity Part 4 of 6: The Fast Solution - YouTubeVisit PuraKai to shop for eco-friendly clothing and stand-up paddle boards. Be sure to use coupon code "latest in paleo" for 15% off all clothing purchases.

A recent study on low carb, high fat (LCHF) diets led to a prominent researcher issuing warnings about the Paleo diet, calling it dangerous, and this rippled out in the media. On this episode, we take a look at that study and show why it is so misleading and why some researchers are calling for a retraction. In other news, a new study shows major health benefits from just a little weight loss, and the CDC tells us 83 million American adults don't get enough sleep. There is also a recap of the Newcastle research, which every diabetic should be aware of. The Moment of Paleo furthers the theme of small changes, big impact. There are new book and documentary recommendations. The After the Bell segment features Dr. Ian Spreadburry's excellent talk for the New Zealand Ancestral Health Symposium further strengthening the proposition that whole food delivers good health—if you don't know the difference between acellular and cellular carbs, you will after this talk, and you'll be glad you do. Enjoy the show! Links for this episode:This Episode's homepageLatest in Paleo on Facebook - News hunters and gatherers post your links here.Full List of Recommended Books & AudiobooksThe Diet Myth: Why the Secret to Weight Loss & Health is Already in Your GutThe Diet Myth | SBS On DemandThe Diet Myth documentary: The real reason we’re fatDiabetes expert warns paleo diet is dangerous and increases weight gain | EurekAlert! Science NewsPaleo diets = weight gain | Pursuit by University of MelbourneNutrition & Diabetes - A low-carbohydrate high-fat diet increases weight gain and does not improve glucose tolerance, insulin secretion or [beta]-cell mass in NZO miceCelebrity chef Pete Evans mocks study showing Paleo diet could make you fatNew study says Paleo diet 'unhealthy and fattening' angering ardent devotees - TelegraphDiet Research Insanity – aaron blaisdell's blogDiet that can help you avoid or even reverse Type 2 diabetes revealed | Daily Mail OnlineBig Health Benefits to Small Weight Loss - The New York TimesEffects of Moderate and Subsequent Progressive Weight Loss on Metabolic Function and Adipose Tissue Biology in Humans with Obesity: Cell MetabolismEven Small Weight Loss Benefits Health | Fort Smith/Fayetteville News | 5newsonline KFSM 5NEWSPrevalence of Healthy Sleep Duration among Adults — United States, 2014 | MMWRThe Americans Who Don’t Get Enough Sleep - WSJA Third of Americans Aren't Getting Enough Sleep - NBC NewsWhite people sleep the most, CDC study finds | Daily Mail OnlineCDC Still Says Americans Aren't Getting Enough Sleep (VIDEO) | Sci/Health > HealthSleep loss gets scary in CDC report - CBS News"Acellular Carbohydrates: Are Our Bacteria a Detector of Dietary Refinement?" - Dr Ian Spreadbury - YouTubeVisit PuraKai to shop for eco-friendly clothing and stand-up paddle boards. Be sure to use coupon code "latest in paleo" for 15% off all clothing purchases.

In this edition, we’ll hear about genes that modulate sleep, with David Prober, Neuron (00:00), how jogging may reduce cancer risk, with Pernille Hojman, Cell Metabolism (6:20), gene editing to fight mosquitos, with Jake Tu and Zach Adelman, Trends in Parasitology (12:40), and top myths about peer reviewers, with Cell Editor-in-Chief Emilie Marcus (19:48). Plus much more!

On this episode of Latest in Paleo: Best drug ad ever; Jimmy Moore’s new Keto cookbook; Paleolithic diet included carbs according to new study; the fat vs. carbs study; and the Danish butter study. There’s a documentary series recommendation, a book recommendation, a Shinrin Yoku Update, a Listener Question about restoring gut flora after antibiotics, a Moment of Paleo, an After the Bell segment about what your doctor won’t disclose, and a bonus clip at the very end! Enjoy! Links for this episode:Episode 141 HomepageLatest in Paleo on Facebook: News Hunters & Gathers post your links!Contact Angelo CoppolaBook Recommendation: Born to Run (US)Nature Rx Part 1 - YouTubeDocumentary Recommendation: BBC - The Truth About FoodDocumentary Recommendation - Truth About Food, Ep 1 - YouTubeThe Ketogenic Cookbook: Nutritious Low-Carb, High-Fat Paleo Meals to Heal Your BodyJimmy Moore's Livin' La Vida Low Carb BlogTwitter: LivinlowcarbmanJimmy Moore (@livinlowcarbman) • Instagram photos and videosHendricks v Starkist Co.StarKist Tuna class action lawsuit: $25 of cash or $50 of tuna. Your choice. - Aug. 27, 2015Costco Announces Sustainable Skipjack Tuna Brand - Greenpeace USAGreenpeace canned tuna list ranks Starkist last | Undercurrent NewsJSTOR: The Quarterly Review of Biology, Vol. 90, No. 3 (September 2015), pp. 251-268What Paleo diet experts think – and why they're wrong | Life and style | The GuardianScientists Say The Original Paleo Diet Had A Large Dose Of Carbs - ForbesScientists confirm that the Paleo diet is nonsense - QuartzCould The Paleo Diet Be a Lie? New Scientific Evidence Flies in Face of ‘It’ Eating PlanLow-Carb Diets Don’t Work the Way We Thought « Inside Health NewsResearchers Question Paleo Diet | Runner's WorldWhat the Hell Is Paleo, Really? | Outside OnlineDear Mark: Anti-Paleo Guardian Column (Plus, Did Big Brains Need Carbs?) | Mark's Daily AppleScientists (sort of) settle debate on low-carb vs. low-fat diets - The Washington PostCalorie for Calorie, Dietary Fat Restriction Results in More Body Fat Loss than Carbohydrate Restriction in People with Obesity: Cell MetabolismDoes one diet really burn more fat? - CBS NewsWhole Health Source: More Thoughts on the Recent Low-fat vs. Low-carb Metabolic Ward StudyWeighty Matters: Guest Post: Dr. Kevin Hall Asks Is The Carbohydrate-Insulin Theory Dead?A brief explanation of Hall et al., ie, THE LOW CARB WAR | The poor, misunderstood calorieButter increased total and LDL cholesterol compared with olive oil however resulted in higher HDL cholesterol than habitual dietButter Industry Funds Study That Found Butter Is Bad for You - AOL OnA study about butter, funded by the butter industry, found that butter is bad for you - The Washington PostNeighborhood greenspace and health in a large urban center : Scientific ReportsExploring connections among nature, biodiversity, ecosystem services, and human health and well-being: Opportunities to enhance health and biodiversity conservationDavid Suzuki: Healthy environments nurture healthy people | CTV NewsThoughts of Bill at 103 | New Zealand Society | Radio New Zealand NationalLeana Wen: What your doctor won’t disclose | TED Talk | TED.com

On this week's information-packed show: an update on prebiotics and probiotics with Tim Steele; Is child obesity really down? Is meat and cheese really as bad as smoking? Are antibiotics making us fat? Plus, a Moment of Paleo and After the Bell. Links for this episode:Full show notes at Angelo's Blog - Humans Are Not BrokenLatestInPaleo Facebook Page -- Post Your News Links Here!Probiotics: The Genetic Component of Obesity | Free The AnimalAnimal PharmJim Gaffigan Disapproves Of The Kale & Weird Milk Fad @ TeamCoco.comWhy Childhood Obesity Has Dropped Among Young Children - Video on NBCNews.comA plunge in U.S. preschool obesity? Not so fast, experts say | ReutersCell Metabolism - Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older PopulationAre Meat And Dairy As Unhealthy As Cigarettes? (VIDEO)High-protein diet 'as bad for health as smoking' - TelegraphScience News, Articles and Information | Scientific AmericanProtein Study Fundamental FlawsI can has cheezburger? Protein cancer risk overblown - health - 04 March 2014 - New ScientistAnimal protein as bad as smoking?!My take on the recent ‘high protein diet as bad a smoking’ study | Dr Briffa's Blog - A Good Look at Good HealthWhy I’m Not Dismissing the Latest “Animal Protein is Bad” Study (But Not Losing Sleep Over It, Either) | Raw Food SOSThe Fat Drug - NYTimes.comPaleo Diet Driving Shift to ‘High-Protein’ Marketing Frenzy (GIS, KRFT, TSN)Do Antibiotics Make Us Fat? | On Point with Tom AshbrookAntibiotics Could Contribute to Weight Gain