Podcasts about ciris

What if you could analyze every metabolite, glycan variant, and unknown impurity in your bioprocess sample—not just the targets you're looking for, but everything that's actually there? Cryogenic infrared ion spectroscopy combined (CIRIS) with AI-powered analysis transforms untargeted screening from aspiration to reality.This episode moves from fundamental principles to practical applications. While Part 1 established how CIRIS overcomes mass spectrometry's structural limitations, Part 2 reveals what becomes possible when you can definitively identify complex mixtures: better mAb characterization, earlier disease detection, and process decisions based on complete data rather than educated guesses.Professor Tom Rizzo returns to discuss Isospec Analytics' path from laboratory innovation to commercial service platform. His transition from academic leadership at EPFL to biotech entrepreneurship offers insights for any scientist considering whether breakthrough research deserves a startup—and what that journey actually requires.For bioprocess scientists drowning in unidentified peaks, struggling with glycan heterogeneity, or making critical manufacturing decisions with incomplete analytical data, this conversation demonstrates how next-generation analytics powered by quantum chemistry and machine learning can illuminate what's been hidden in your samples all along.Episode Highlights:Why targeted metabolomics creates a "streetlight effect"—and how untargeted CIRIS analysis reveals the complete molecular landscape (00:00)Isomer-specific glycan characterization for mAbs: distinguishing structural variants that impact efficacy and immunogenicity (03:17)Advanced disease detection and biomarker discovery: identifying diagnostic signatures in complex biological matrices (05:21)AI meets quantum chemistry: automated spectral library building and machine learning algorithms that accelerate molecule identification from hours to seconds (06:05)From data generation to decision-making: how comprehensive analytics and AI transform bioprocess development workflows (09:23)Isospec's commercial roadmap: service platform for comprehensive sample analysis and projected timeline for benchtop instrumentation (10:09)Academic to entrepreneur: Tom Rizzo's perspective on leaving tenure for a startup, with practical advice for scientists evaluating the leap (12:05)Personal motivation behind early diagnostics: cancer and leukemia experiences that drive Isospec's clinical applications (14:11)Technical deep dive: messenger tagging methodology and achieving single-ion infrared detection sensitivity (15:41)The transformative capability: adding a structural dimension to mass spec data that eliminates ambiguity in complex mixture analysis (17:55)Mass spectrometry tells you what masses are present. Cryogenic infrared ion spectroscopy tells you what molecules they actually are. When coupled with AI-powered analysis, this combination enables truly comprehensive characterization—from process impurity identification to critical quality attribute assessment to early disease biomarker discovery.If you're making bioprocess decisions with incomplete analytical information, managing glycan complexity in biologics development, or exploring how emerging analytical technologies could solve your toughest characterization challenges, this episode provides both the technical foundation and the commercial pathway forward.

What if you could identify every structural variant in your biologics—without ambiguity, without massive sample requirements, and without the guesswork that plagues traditional mass spectrometry? Cryogenic infrared ion spectroscopy (CIRIS) makes it possible, transforming molecular characterization from frustrating puzzle to precise science.Today's guest, Professor Tom Rizzo, bridges the gap between academic innovation and industrial application. As former Dean of the School of Basic Sciences at EPFL in Lausanne and now Chief Scientific Officer at Isospec Analytics, Tom has spent over two decades developing analytical techniques that solve problems conventional methods can't touch.His journey from a childhood fascination sparked by chemistry demonstrations at the 1964 New York World's Fair to pioneering a breakthrough technology reveals both the persistence required for true innovation and the pathway from laboratory curiosity to commercial reality. For bioprocess scientists struggling with glycan characterization, isomer identification, or any structural puzzle where mass spec alone falls short, this conversation offers both validation and solutions.Episode Highlights:The fundamental limitations of current biomolecular analysis methods and why innovation is critical (02:51)From World's Fair chemistry demos to laser spectroscopy: Tom Rizzo's path to analytical innovation (03:31)The two-decade quest to combine mass spectrometry sensitivity with laser spectroscopy precision—and the machine that finally made it work (04:26)Why Tom transitioned from academic leadership to Isospec Analytics: bringing lab techniques to production environments (09:17)CIRIS fundamentals: how cooling ions to 10 Kelvin unlocks molecular fingerprints that room-temperature methods miss (11:14)CIRIS advantages for biologics: single-ion sensitivity, isomer discrimination, and unique molecular "fingerprints" for definitive identification (14:25)Integrating CIRIS into existing bioprocess workflows: LC-MS compatibility and the path to commercial instrumentation (17:29)Hard-won lessons from translating academic breakthroughs into industrial tools (17:43)When mass spectrometry hits its limits—distinguishing isomers, characterizing glycans, identifying unknowns in complex mixtures—cryogenic infrared ion spectroscopy provides the structural resolution you need. This isn't incremental improvement; it's a fundamental expansion of what's analytically possible.If you're facing molecular identification challenges that conventional methods can't solve, or if you're curious how next-generation analytical techniques will transform bioprocess development, this episode delivers actionable insights from a scientist who's lived both the innovation and implementation journey.Connect with Tom Rizzo:LinkedIn: www.linkedin.com/in/thomas-rizzo-4a0a6314/Contact email: tom@isospec.chIsospec Analytics website: www.isospecanalytics.comNext step:Book a 20-minute call to help you get started on any questions you may have about bioprocessing analytics: https://bruehlmann-consulting.com/call

In a captivating conversation, Eric Heilman, the executive director of CIRIS, explored the fascinating realm of institutional research (IR) within independent schools alongside the ATLIS co-hosts. The central focus of the discussion was data culture and its pivotal role in shaping decision-making processes within educational institutions.After sharing his backstory, Eric emphasized the critical importance of cultivating a data-driven culture within schools. He highlighted that the long-term success of an IR program is often more profoundly influenced by the school's prevailing culture than the technical expertise of the person spearheading it.During the conversation, the trio delved into an exciting new development—the imminent release (which is now available!) of a comprehensive guidebook designed to assist schools in launching their own institutional research programs. The guidebook covers a wide array of topics, including data strategy, data governance, and the intricate technical aspects of data analysis. Notably, the discussion touched upon the burgeoning influence of artificial intelligence (AI) in data analysis, particularly in the realm of automating the qualitative coding of open-ended survey responses.Data silos, a pervasive challenge in educational institutions, also came under scrutiny. The participants stressed the importance of breaking down these data silos and fostering collaboration through the establishment of data strategy committees.Diversity, equity, and inclusion (DEI) initiatives were a hot topic during the conversation. Schools are increasingly focusing on tracking relevant data to inform their efforts in these areas, but they are also recognizing the need to protect sensitive data and maintain privacy.The conversation took an intriguing turn as the participants discussed how schools decide which questions to explore through their IR programs. They highlighted the necessity of involving the entire school community in the decision-making process to foster a constructive data culture.In the end, the podcast left listeners with a deeper understanding of the evolving landscape of institutional research and the pivotal role it plays in shaping the future of education.Resources mentioned on the showData-Informed Decision Making: A Guide to Institutional Research in Independent Schools https://ciris.maret.org/ciris-resources/community-resources/ciris-guidehttps://www.maret.org/about-us/institutional-researchConnect with Eric on LinkedIn: https://www.linkedin.com/in/eric-heilman-8aa196163/Center for Institutional Research in Independent Schools (CIRIS) https://ciris.maret.org/Boomer the dog on Instagram (Eric's dog) @boomer.tha.berner https://www.instagram.com/boomer_the_berner/Listen, rate, and subscribe!

NTNU Samfunnsforsknings romforskeravdeling CIRiS lager utstyr og utvikler løsninger for bemannet romfart. Når kommer vi oss til månen igjen, og på hvordan måte er CIRiS og Trondheim med på laget? Øyvind Mejdell Jakobsen er med på Forskerpoddens årsoppsummering. Programleder er Vegard Y. Smevoll.

Neste episódio Fabíola Junqueira e Flora Villas falam sobre dificuldades da ciência ao longo da história e sua relação com alguns governos ao longo do tempo. Elas conversaram com o professor Marko Monteiro, um dos líderes do grupo de pesquisa CIRIS, que investiga Governança, Riscos e Comunicação no Brasil.

Neste episódio a Fabíola Junqueira e a Flora Villas falam sobre o oitavo workshop realizado pelo GEICT, o Grupo de Estudos Interdisciplinares em Ciência e Tecnologia da Unicamp, realizado em parceria com o grupo CIRIS, dedicado a pesquisar Governança, Risco e Comunicação a partir da crise da COVID-19. 

Refresquem algunes bromes i acudits de tres grans humoristes i bohemis del segle XIX i comen

Agradece a este podcast tantas horas de entretenimiento y disfruta de episodios exclusivos como éste. ¡Apóyale en iVoox! #EquipoPUR #Balonmano #NORCECA Conversamos con la atleta puertorriqueña e integrante del equipo femenino de Balonmano Caris García | Victoria contra Estados Unidos en el NORCECA Femenino | Luis Jabdiel Pérez lleva el Judo puertorriqueños al más alto escenario en los Juegos Paralímpicos | Mucho más…Escucha este episodio completo y accede a todo el contenido exclusivo de Bonita Radio. Descubre antes que nadie los nuevos episodios, y participa en la comunidad exclusiva de oyentes en https://go.ivoox.com/sq/90599

#EquipoPUR #Balonmano #NORCECA Conversamos con la atleta puertorriqueña e integrante del equipo femenino de Balonmano Caris García | Victoria contra Estados Unidos en el NORCECA Femenino | Luis Jabdiel Pérez lleva el Judo puertorriqueños al más alto escenario en los Juegos Paralímpicos | Mucho más…

Hva skjedde da NASA landet på Mars torsdag 18. februar? Hva leter de etter? Hvordan har flere norske rommiljø klart å bli med på ferden? Hva betyr det for NTNU Samfunnsforskning og CIRiS? Hør hvordan forsker og romentusiast Irene Karoliussen opplevde Mars-landingen, i samtale med programleder Vegard Smevoll.

Forskerne i NTNU Samfunnsforsknings underavdeling CIRiS, Senter for tverrfaglig forskning i rommet, jobber vanligvis med ferden opp til månen og Mars. Hva skal til for at vi skal klare oss på så lange romreiser? Deres nyeste prosjekt handler om mer landlige forhold. Går det an å bruke samme kompetanse til å utnytte restevann etter lakseproduksjon? Kan det brukes til å dyrke planter? Programleder Vegard Smevoll har med seg seniorforsker Øyvind Mejdell Jakobsen i CIRiS og forsknings- og utviklingsleder Kari Attramadal i det trønderske selskapet Nofitech. Begge er enige om dette vannet kan utnyttes bedre! Forskningsprosjektet er finansiert av Regionale forskningsfond Trøndelag.

Akkurat nå er NTNU Samfunnsforskning igang med et nytt prosjekt, hvor målet er å finne ut hvordan lungeceller fra friske mennesker klarer seg i vektløs tilstand. Ja, du hørte riktig. Om tre år vet vi mer om hvordan cellene klarer seg på lengre romreiser, kanskje helt til Mars. Forskningen kan også hjelpe pasienter med kols og astma. Biolog og CIRiS-forsker Irene Karoliussen forklarer, programleder Vegard Smevoll stiller spørsmålene.

Forskningssjef Ann-Iren Kittang Jost, sjef på vår avdeling CIRiS, har vært med på å forske på dyrking av planter på den internasjonale romstasjonen (ISS) i 12 år. Hvordan kan denne kunnskapen brukes når amerikanerne planlegger retur til månen? Hva har vi lært siden Neil Armstrong gikk på månen for snart 50 år siden? Og når kommer vi oss til Mars? Forskningssjef Ann-Iren Kittang Jost Svarer. Programleder Vegard Smevoll stiller spørsmålene.

In this episode we talk about…Falcon heavy spacex, WhereML, the rise of reputation networks, JDK 10 and Lady Doritos! Coffee from Costa, Chancery Lane. Where bytes and bites collide.

In this episode we talk about…Falcon heavy spacex, WhereML, the rise of reputation networks, JDK 10 and Lady Doritos! Coffee from Costa, Chancery Lane. Where bytes and bites collide.

Ciris and Chen continue their respective investigations and ultimately find themselves in each others path…

The war has ended and Ciris and the center have emerged victorious.  But Ciris must still make amends with those she’s alienated and scorned, and come to terms with she’s learned.  Somehow, fighting a psychotic Cyborg seems simple by comparison…

Ciris and Chen split up and carry out their objectives for the night.  For Chen that is to get back to the Center and prepare them for the impending attack.  For Ciris, that’s to steal the data in Allenrod’s mainframe, and then catch up with Chen at the center.  Meanwhile, as Chen struggles to convince Tecgui and Briggs of tonight’s danger, Allenrod’s forces are on the move…

Ciris and Chen regroup, compare notes and try to put the pieces together in order to determine Allenrod’s plans.

When Agent Chen misses their arranged lunch, Ciris grows nervous and begins to search for her.  As she scours Allenrod’s Manor, she comes face to face with a few surprises she had not been expecting….

In the aftermath of Ciris’s assault against Tecgui, Briggs is forced to respond and send another agent after her.  In the meantime, Ciris finds herself at a loss and after some advice from an unexpected source, begins a search for the ever elusive truth.

The next morning things between Ciris and Chen continue to remain edgy at best.  After another confrontation about the events of the previous night, the two part company for the morning.  Both Ciris and Chen find answers, but one finds more than she bargained for….

Having sealed their deal, Ciris and Chen keep the appointment with Xavier Allenrod.  But will this meeting answer Ciris’s questions or will they just pose new ones?

The next morning, Ciris is teamed up with Agent Chen Min-Weh.  Together they review what Dr. Wass found during the autopsy of Dr. Quincy.  Those results lead Ciris back to Leila Richardson who has a few surprises of her own…

In the aftermath of the attack on her apartment, Ciris finds herself sequestered by Tecgui.  Off the front lines while the CNSCP finishes their analysis and develops a new strategy, Ciris uses the down time to confront Tecgui with her suspicions.  Meanwhile, Tecgui and Briggs sense Ciris is getting too close for comfort…

Ciris learns how SMT developed their prototypes.  When she returns, Ciris continues her investigations into the genesis of Project Delphi.  Her disturbing discoveries and their dark implications lead Ciris to a hostile confrontation with one of the Center’s own…

After the fundraiser draws to a close, Ciris returns home to rest, and reflect on her experience in the Civic Center construct.  However, others have their own agenda for her on this night...

The pursuit of Quincy is short lived as Ciris finds herself re-assigned to protect the Director.  For once thigns seem to be going according to plan, until a certain hacker returns with startling implications.

As she recovers from the mission, Ciris reflects on the technology that sustains her, how it came to be a part of her, and how the aftermath has affected her.  

Ciris returns to duty the next day, but it is not destined to be a good one.  Up first for her — report to the unhappy Director and hear what he has to say.  The bad news doesn’t end there and Ciris finds her frustration building to another destructive end.

When a blackout grips the city, Briggs is forced to sends the only agent available to him to investigate…Ciris.  But her troubles are far from over when she discovers an outside influence at work.