Podcasts about limitations

  • 8,146PODCASTS
  • 12,025EPISODES
  • 37mAVG DURATION
  • 2DAILY NEW EPISODES
  • Dec 28, 2025LATEST

POPULARITY

20192020202120222023202420252026

Categories



Best podcasts about limitations

Show all podcasts related to limitations

Latest podcast episodes about limitations

Alchemy For Life  -  How to's, observations, and tangible doable solutions to reduce stress, get control, have more fun.

You do less, but you get more. Well, hey there. Welcome back. Do you have any limitations? Oh, yes, of course you do. Let’s talk about them. And I think your first reaction is, “Well, here we go. We’re going to explore how I’m not good enough at something or how I don’t even do a thing.” Nope, we’re not doing that at all. In fact, we are going to look at why limitations are so important and how they actually make a product, a business, and a person better. What is this? Real life? Yes, I’m here to tell you yes, it is. The Danger of Trying to be Good at Everything in 2026 I read a book a while back called The Myth of Excellence. And one of the things it says in the book, and I’m paraphrasing, is the best way to sort of destroy your business and go out of business is to try to be good at everything. Years ago, I worked at a firm that had that same motto. And they tried to be good at everything and tell all of their clients that they could do anything and everything that their clients were asking. And they couldn’t. In their quest to be good at everything, they were essentially good at nothing. The Success of the 10-Minute Podcast Constraint When I started this podcast—and we are approaching 300 episodes in 2026—when I started it, the very first episode, I set a rule for myself. I set a limitation and the limitation was I would keep the episode if it was just me to about 10 minutes. I have adhered to that and every so often I go over to maybe 11 or 12 minutes and then I apologize profusely. That limitation has helped me to have a better show. It has helped me to have a show that’s better because it forces me to be more concise, but it also makes my show very different. When people find out that my show is only 10 minutes long, they’re shocked. And they’re shocked in a very pleasant way. They’re like, “Oh, I can digest that. Oh, I’ll just go empty the dishwasher and listen to your show.” “Oh, okay. Wow, that’s it.” I’ve had multiple people come to me and say, “Oh, yeah. I listen to like seven of your episodes.” Wow. Like so that’s really a cool thing that limitation has been very advantageous. Defining Strategic vs. Self-Improvement Limitations At the time of year that this podcast episode is coming out is we’re we’re we’re ending the year and it’s when everyone is making New Year’s resolutions and saying they’re going to be better and this and that. They’re probably looking at limitations as something they’re going to overcome. And yes, there are certain things that you want to improve. You want to be better at weight loss. You want to be better at at consistency at this that the other thing. Yes. So, you’re sort of overcoming your scale and you’re saying, “I want this to be a seven when it’s only a three right now.” That’s fine. What I’m talking about are limitations that are typically self-imposed for a reason. If you’re running a business and you set limitations, you will find that very comforting. You will create a sort of comfort zone for you, your skills, your people, and yourself. You can do that for yourself as well where you have a limitation in something that you do whether it’s well when people ask for rides or they ask for favors I have a limitation of such and such and it can help you to maintain consistency and integrity and you’re kind of shaking your head right now going wait I never really looked at it that way it’s a positive thing yes it’s an absolute positive thing. Maintaining Professional Integrity with Time Limits Getting back to my use of it when I interview people and I am exceeding exceedingly grateful for the chances I’ve had so far with interviewing people. When I interview people, I always start it by telling them when I first approach them, I’m only going to use an hour of your valuable time, no more. I promise. And I’m surprised at how many of those people view that as they they act like this is a new thing. Like no one has ever approached them for an interview and said, “Here’s our time limit.” And there are obvious reasons for that, right? If you are running a show and you get somebody that you think is going to be really good, you want to squeeze every single delicious minute out of them that you can. So, you are actually doing yourself a disservice in their shortsighted view of it of saying, “Hey, I I told the guy it was only an hour, but he was willing to go longer. Darn it. Why did I do that?” Well, if he is willing to go longer, then you can go longer. And I had a guest that easily did an hour and a half and wanted to actually do more where I actually had to push back and say, “You know what? Why don’t you come back?” So again, a limitation simply related to the podcast and timing. And I want to stress again that these limitations, unlike self-improvement limitations per se, are self-imposed limitations that have to do with something that you think is a good thing. Like for example, this is not, oh, I’m just going to limit myself to have only one and a half cakes. No, I’m not talking about like limiting your eating and things like that. Those are just that’s a different concept. This concept is there’s a thing that I do or enjoy or or could do, but I don’t. The Business Advantage of Scarcity and Brand Recognition Getting back to the business again, if you’re a creator and let’s say you create 3D printed objects, you may limit yourself to things that are not so fragile or things that are small or things that are really easy to ship. Can you create and print the larger things? Absolutely. Are those high ticket items? Absolutely. Are those things that people request? Sure. But you may just say, “No, I limit myself and I don’t do those. Maybe if I do a a in-person fair somewhere, I may print those and bring those with me. But when it comes to my online store, I limit myself to only doing the little tiny things.” Could Chick-fil-A be open on a Sunday? Yes, but they limit themselves and they’re not open on a Sunday. Not being open on a Sunday costs them an estimated 1 billion with a B dollars of revenue, but they actually gain more than that because it gives them more brand recognition. It increases scarcity because people think, “Oh, I want, oh, it’s closed. Oh, I better go there on Tuesday then.” So, it’s a net gain for them limiting themselves of actually not allowing their customers to buy their products on one day every single week. Hobby Lobby is the same way and they both create a certain image in the mind of many consumers, an image that they cannot create without creating that limitation. Setting Social Boundaries to Protect Your Time and Energy If they say, “Oh yeah, we have morals and ethics and this and we want our people to be taken care of.” Sure, any business can say that. But a business that actually forces itself to be closed on a specific day can say that you too can create that perception. And I don’t mean just a perception like it’s false. I mean a perception in other people of your behavioral patterns by enforcing a limitation. You can present yourself as someone who’s very friendly to your friends and say, “Oh yeah, I’ll help out anytime. Just call me.” Okay, but a lot of people say that. But if you say, “If you want me to help you, let me know.” but you’re going to give me some lead time or I can’t help you. It shows them that you’re serious. It shows them that you actually are committing to helping them, but they are going to also have to come step up to you and say, “Hey, you know, I didn’t just think of this out of nowhere. I actually need help and I’m going to do some planning.” You know, do emergencies happen? Of course. But I’m saying by pushing back and forcing a limitation on your kindness in a way it can help people to say, “Oh, he’s actually serious about that.” Conclusion: Why Doing Less Allows You to Get More Banks, restaurants, retail, etc., etc. The list goes on. There probably isn’t a business out there that doesn’t have a limitation that they self-imposed. There isn’t a business out there that some of the people in a round table, CEO, CFO, what have you, see people, marketing, what have you, sat down and said “well you know we could do this right?” and the answer was yes but we’re not going to and we’re not going to because it is a limitation that we are imposing and there’s usually push back of yes but we’ll see this increase in revenue yes but it’s just not part of our brand or it’s just moving forward not something we really want to do. Imposing limitations on yourself, your business, etc. can be extremely valuable. It can be something that reduces your stress, reduces your time, energy, and resources. Again, it’s one of those things I try to introduce in these podcasts where you do less, but you get more. And it shouldn’t work that way, but it does. So, what in your life is something that you intentionally or unintentionally have realized you’re setting a limitation on? And if you’re a business owner, this may be something that is a 50-page document, your operating agreement. Or if you’re a person running a human being, yourself or your children, it may be something that you’ve just come to realize is something that you do. So, what do you do? What what do you not do and why? It’s something worth looking into. And again, if you’re using the CheckMark™ app, then this podcast will automatically have its own little worksheet built in that you can click and copy to your clipboard and then kind of go through the homework of this. And it’s not homework per se, but it’s something that is a really cool thing that allows you to kind of go through review of this episode. And I I don’t really know of any other podcasts out there that that try to give you a lot of good information in 10 minutes and that allow you to use a fun little app to go through it and say, “Oh yeah, yep. I did this. I did this.” And it’s much better at retaining and it’s kind of a fun interactive thing. And that, my friends, is my 10 minutes. Thank you. PS – See Top 10 things you can do NOW to be successful in 2026 for things you can do now for success. As a bonus you can snag the CheckMark™ ap for free for your phone and desktop that will help you to track, motivate yourself, and make being successful in 2026 just downright fun.

PulmPEEPs
113. RFJC – PREDMETH

PulmPEEPs

Play Episode Listen Later Dec 23, 2025 Transcription Available


Today, Dave Furfaro, Luke Hedrick, and Robert Wharton discuss the PREDMETH trial published in The New England Journal of Medicine in 2025. This was a non-inferiority trial comparing prednisone to methotrexate for upfront therapy in treatment-naive sarcoidosis patients. Listen in for a break down of the trial, analysis, and clinically applicable pearls. Article and Reference Todays’ episode discusses the PREDMETH trial published in NEJM in 2025. Kahlmann V, Janssen Bonás M, Moor CC, Grutters JC, Mostard RLM, van Rijswijk HNAJ, van der Maten J, Marges ER, Moonen LAA, Overbeek MJ, Koopman B, Loth DW, Nossent EJ, Wagenaar M, Kramer H, Wielders PLML, Bonta PI, Walen S, Bogaarts BAHA, Kerstens R, Overgaauw M, Veltkamp M, Wijsenbeek MS; PREDMETH Collaborators. First-Line Treatment of Pulmonary Sarcoidosis with Prednisone or Methotrexate. N Engl J Med. 2025 Jul 17;393(3):231-242. doi: 10.1056/NEJMoa2501443. Epub 2025 May 18. PMID: 40387020. https://www.nejm.org/doi/full/10.1056/NEJMoa2501443 Meet Our Hosts Luke Hedrick is an Associate Editor at Pulm PEEPs and runs the Rapid Fire Journal Club Series. He is a senior PCCM fellow at Emory, and will be starting as a pulmonary attending at Duke University next year. Robert Wharton is a recurring guest on Pulm PEEPs as a part of our Rapid Fire Journal Club Series. He completed his internal medicine residency at Mt. Sinai in New York City, and is currently a first year pulmonary and critical care fellow at Johns Hopkins. Key Learning Points Clinical context Prednisone remains the traditional first-line treatment for pulmonary sarcoidosis when treatment is indicated, with evidence for short-term improvements in symptoms, radiographic findings, and pulmonary function—but with substantial, familiar steroid toxicities (weight gain, insomnia, HTN/DM, infection risk, etc.). Despite widespread use, glucocorticoids haven't been robustly tested head-to-head against many alternatives as initial therapy, and evidence for preventing long-term decline (especially in severe disease) is limited. Immunosuppressants (like methotrexate) are often used as steroid-sparing agents, but guideline recommendations are generally conditional/low-quality evidence, and practice varies. Why PREDMETH matters It addresses a real-world question: Can methotrexate be an initial alternative to prednisone in pulmonary sarcoidosis, rather than being reserved only for steroid-sparing later? It also probes a common clinical belief: MTX has slower onset than prednisone (often assumed, not well-proven). Trial design (what to know) Open-label, randomized, noninferiority trial across 17 hospitals in the Netherlands. Included patients with pulmonary sarcoidosis who had a clear pulmonary indication to start systemic therapy (moderate/severe symptoms plus objective risk features like reduced FVC/DLCO or documented decline, plus parenchymal abnormalities). Excluded: non–treatment-naïve patients and those whose primary indication was extrapulmonary disease. Treat-to-tolerability with escalation: both drugs started low and were slowly increased; switch/add-on allowed for inadequate efficacy or unacceptable side effects. Primary endpoint: change in FVC (with the usual caveat that FVC is “objective-ish,” but effort-dependent and not always patient-centered). Noninferiority margin: 5% FVC, justified as within biologic/measurement variation and “not clinically relevant.” Outcomes assessed at weeks 4, 16, 24; powered for ~110 patients to detect the NI margin. Patient population (who this applies to) Mostly middle-aged (~40s) with mild-to-moderate physiologic impairment on average (FVC ~77% predicted; DLCO ~70% predicted). Netherlands-based cohort with limited Black representation (~7%), which matters for generalizability. Would have been helpful to know more about comorbidities (e.g., diabetes), which can strongly influence prednisone risk. Main findings (what happened) Methotrexate was noninferior to prednisone at week 24 for FVC: Between-group difference in least-squares mean change at week 24: −1.17 percentage points (favoring prednisone) with CI −4.27 to +1.93, staying within the 5% NI margin. Timing mattered: Prednisone showed earlier benefit (notably by week 4) in FVC and across quality-of-life measures. By week 24, those early differences largely washed out—possibly because MTX “catches up,” and/or because crossover increased over time. In their reporting, MTX didn't meet noninferiority for FVC until week 24, supporting the practical message that prednisone works faster. Crossover and analysis nuance (important for interpretation) Crossover was fairly high, which complicates noninferiority interpretation: MTX arm: some switched to prednisone for adverse events and others had prednisone added for disease progression/persistent symptoms. Prednisone arm: some had MTX added. In noninferiority trials, heavy crossover can bias intention-to-treat analyses toward finding “no difference” (making noninferiority easier to claim). Per-protocol analyses avoid some of that but introduce other biases. They reported both. Safety signals (what to remember clinically) Adverse events were very common in both arms (almost everyone), mostly mild. Side-effect patterns fit expectations: Prednisone: more insomnia (and classic steroid issues). MTX: more headache/cough/rash, and notably liver enzyme elevations (about 1 in 4), with a small number discontinuing. Serious adverse events were rare; numbers were too small to confidently separate “signal vs noise,” but overall known risk profiles apply. Limitations (why you shouldn't over-read it) Open-label design, and FVC—while objective-ish—is still effort-dependent and can be influenced by expectation/behavior. Small trial, limiting subgroup conclusions (e.g., severity strata, different phenotypes). Generalizability issues (Netherlands demographics; US populations have higher rates of obesity/metabolic syndrome, which may tilt the steroid risk-benefit equation). Crossover reduces precision and interpretability of between-group differences over time. Practice implications (the “so what”) For many patients with pulmonary sarcoidosis needing systemic therapy, MTX is a reasonable initial alternative to prednisone when thinking long-term tolerability and steroid avoidance. Prednisone likely provides faster symptom/QoL relief in the first weeks—so it may be preferable when rapid improvement is important. The trial strengthens the case for a patient-centered discussion: short-term relief vs side-effect tradeoffs, and the possibility of early combination therapy in more severe cases (suggested, not proven).

Faithwalking English
Keep Calm: Facing - and Embracing - Our Limitations

Faithwalking English

Play Episode Listen Later Dec 23, 2025 12:19


In this episode Lou Huesmann talks about one of the sources of our anxiety as human beings - the feeling that we should do more and be more. We face limitations - we are creatures created to be dependent on God, other people, and the earth. In our culture dependence is viewed negatively, yet God created us this way and declared it good - and Jesus took on our humanity and our finitude! God endorses our humanity! Our limitations therefore are not failures on our part, but the way we were created to be; we are designed for relationship and interdependence. This episode was recorded on December 19, 2025.

LessWrong Curated Podcast
"Alignment Pretraining: AI Discourse Causes Self-Fulfilling (Mis)alignment" by Cam, Puria Radmard, Kyle O'Brien, David Africa, Samuel Ratnam, andyk

LessWrong Curated Podcast

Play Episode Listen Later Dec 23, 2025 20:57


TL;DR LLMs pretrained on data about misaligned AIs themselves become less aligned. Luckily, pretraining LLMs with synthetic data about good AIs helps them become more aligned. These alignment priors persist through post-training, providing alignment-in-depth. We recommend labs pretrain for alignment, just as they do for capabilities. Website: alignmentpretraining.ai Us: geodesicresearch.org | x.com/geodesresearch Note: We are currently garnering feedback here before submitting to ICML. Any suggestions here or on our Google Doc are welcome! We will be releasing a revision on arXiv in the coming days. Folks who leave feedback will be added to the Acknowledgment section. Thank you! Abstract We pretrained a suite of 6.9B-parameter LLMs, varying only the content related to AI systems, and evaluated them for misalignment. When filtering the vast majority of the content related to AI, we see significant decreases in misalignment rates. The opposite was also true - synthetic positive AI data led to self-fulfilling alignment. While post-training decreased the effect size, benign fine-tuning[1] degrades the effects of post-training, models revert toward their midtraining misalignment rates. Models pretrained on realistic or artificial upsampled negative AI discourse become more misaligned with benign fine-tuning, while models pretrained on only positive AI discourse become more aligned. This [...] ---Outline:(00:15) TL;DR(01:10) Abstract(02:52) Background and Motivation(04:38) Methodology(04:41) Misalignment Evaluations(06:39) Synthetic AI Discourse Generation(07:57) Data Filtering(08:27) Training Setup(09:06) Post-Training(09:37) Results(09:41) Base Models: AI Discourse Causally Affects Alignment(10:50) Post-Training: Effects Persist(12:14) Tampering: Pretraining Provides Alignment-In-Depth(14:10) Additional Results(15:23) Discussion(15:26) Pretraining as Creating Good Alignment Priors(16:09) Curation Outperforms Naive Filtering(17:07) Alignment Pretraining(17:28) Limitations(18:16) Next Steps and Call for Feedback(19:18) Acknowledgements The original text contained 1 footnote which was omitted from this narration. --- First published: December 20th, 2025 Source: https://www.lesswrong.com/posts/TcfyGD2aKdZ7Rt3hk/alignment-pretraining-ai-discourse-causes-self-fulfilling --- Narrated by TYPE III AUDIO. ---Images from the article:

Barenaked Money
Powers of Attorney: Do's, Don'ts, and Opportunities for Disaster with Jonathan Hooper

Barenaked Money

Play Episode Listen Later Dec 23, 2025 50:27 Transcription Available


The Unseen Complexities of Powers of Attorney and Estate PlanningIn this episode of 'Barenaked Money,' returning guest Jonathan Hooper delves into the intricate world of powers of attorney, offering essential advice on appointing the right person for the role. The discussion covers the types of powers of attorney, including immediate and deferred, and their specific functions in managing your financial and property-related decisions. Jonathan also highlights the potential pitfalls and legal constraints that can arise, emphasizing the importance of trust and capability in chosen representatives. The podcast underscores the necessity of professional advice and transparent conversations within family dynamics to ensure a seamless transition and avoid costly legal disputes posthumously.Click here to view the episode transcript. 00:00 Introduction: Choosing the Right Power of Attorney00:31 Welcome Back: Guest Introduction01:31 Understanding Powers of Attorney02:19 Types of Powers of Attorney05:02 Responsibilities and Limitations of a Power of Attorney05:49 Executor vs. Power of Attorney08:40 Common Pitfalls and Misconceptions11:26 Planning and Legal Considerations21:43 Avoiding Probate and Tax Implications25:54 Legal and Relational Risks in Estate Planning28:23 The Complexity of Provincial and Federal Regulations30:00 Choosing the Right Power of Attorney33:38 Professional Options for Power of Attorney36:53 The Emotional and Practical Challenges of Estate Planning42:56 The Importance of Professional Advice48:14 Conclusion and Final Thoughts

Legal Issues In Policing
E133| To arrest or not (2) arrest? That is the question.

Legal Issues In Policing

Play Episode Listen Later Dec 23, 2025 46:16


Provide your feedback here. Anonymously send me a text message. In this episode, Mike discusses the Supreme Court of Canada decision R. v. Carignan, 2025 SCC 43 where a police officer arrested a man under s. 495 of the Criminal Code. At trial, in the Court of Quebec, the man wanted a voir dire held to determine the lawfulness of his arrest because — he claimed — the police did not comply with s. 495(2) and he sought the exclusion of an incriminating statement he made to police under s. 24(2) of the Charter. But the judge refused to hold a voir dire, concluding s. 495(3) rendered an arrest that did not comply with s. 495(2) lawful in a criminal proceeding, including one in which the arrestee was on trial. The man was convicted of sexual assault and he was sentenced to 15 months' imprisonment and placed on probation for a period of two years. He appealed to Quebec's highest court, which ruled the trial judge erred. In its view, s. 495(3) did not prevent an accused from challenging the legality of their arrest. By refusing to hold a voir dire, the judge deprived the man of the opportunity to allege and establish non-compliance with s. 495(2). The man's appeal was allowed and a new trial was ordered. The Crown then appealed the Quebec Court of Appeal's decision to Canada's top court, where all nine judges heard the matter and rendered an unanimous decision. Listen to learn what every law enforcement officer should know about the effect non compliance with s. 495(2) has on the lawfulness of an arrest made under s. 495(1) and its interplay with s. 495(3). Criminal Code power of arrest:495 (1) A peace officer may arrest without warrant(a) a person who has committed an indictable offence or who, on reasonable grounds, he believes has committed or is about to commit an indictable offence(b) a person whom he finds committing a criminal offence; or(c) a person in respect of whom he has reasonable grounds to believe that a warrant of arrest or committal, in any form set out in Part XXVIII in relation thereto, is in force within the territorial jurisdiction in which the person is found.Limitation(2) A peace officer shall not arrest a person without warrant for(a) an indictable offence mentioned in section 553,(b) an offence for which the person may be prosecuted by indictment or for which he is punishable on summary conviction, or(c) an offence punishable on summary conviction,in any case where(d) he believes on reasonable grounds that the public interest, having regard to all the circumstances including the need to(i) establish the identity of the person,(ii) secure or preserve evidence of or relating to the offence, or(iii) prevent the continuation or repetition of the offence or the commission of another offence, may be satisfied without so arresting the person, and(e) he has no reasonable grounds to believe that, if he does not so arrest the person, the person will fail to attend court in order to be dealt with according to law.Consequences of arrest without warrant(3) Notwithstanding subsection (2), a peace officer acting under subsection (1) is deemed to be acting lawfully and in the execution of his duty for the purposes of(a) any proceedings under this or any other Act of Parliament; and(b) any other proceedings, unless in any such proceedings it is alleged and established by the person making the allegation that the peace officer did not comply with the requirements of subsection (2).Other provisions mentioned in the podcast: ss. 493, 49Thanks for listening! Feedback welcome at legalissuesinpolicing@gmail.com

REBEL Cast
REBEL Core Cast 147.0–Ventilators Part 5: Key Mechanical Ventilator Pressures & Definitions Made Simple

REBEL Cast

Play Episode Listen Later Dec 22, 2025 14:20


🧭 REBEL Rundown 🗝️ Key Points 💨 Peak vs. Plateau Pressures: PIP reflects total airway resistance and compliance, while Pplat isolates alveolar compliance—elevations in both suggest decreased lung compliance (e.g., ARDS, pulmonary edema, pneumothorax).🧱 PEEP Protects Alveoli: Maintains alveolar recruitment and prevents collapse; typical range 5–8 cmH₂O, but higher levels may benefit moderate–severe ARDS.️ Driving Pressure (ΔP = Pplat − PEEP): Lower ΔP reduces atelectrauma and improves outcomes; optimize by adjusting PEEP thoughtfully.💥 Prevent VILI: Keep Pplat < 30 cmH₂O, use low tidal volumes (6 mL/kg IBW), and monitor for barotrauma, volutrauma, atelectrauma, and biotrauma.📚 Evidence-Based Practice: ARDSNet and subsequent trials confirm that lung-protective ventilation—low Vt, limited pressures, and individualized PEEP—improves survival in ARDS. Click here for Direct Download of the Podcast. 📝 Introduction This episode reviews essential ventilator pressures and how to interpret them during ICU rounds. 🚀 Under Pressure Peak Inspiratory Pressure (PIP)Definition: Total pressure required to deliver a breath.Reflects: Airway resistance + lung/chest wall compliance.Common Causes of ↑ PIP:Mucus pluggingBiting the endotracheal tubeKinked tubing or bronchospasmPlateau Pressure (Pplat)Definition: Alveolar pressure measured after an inspiratory hold.Reflects: Lung compliance (stiffness of lung tissue).When Both PIP & Pplat Are Elevated:→ Indicates poor compliance (e.g., ARDS, pulmonary edema, pneumothorax).Positive End-Expiratory Pressure (PEEP)Definition: Pressure remaining in airways at end-expiration to prevent alveolar collapse.Typical Range: 5–8 cmH₂O but needs to titrated to meet patient requirements Notes:Provides physiologic “glottic” PEEP in intubated patients.Using high PEEP strategy shows mortality benefit only in moderate–severe ARDS in meta-analysis.Driving Pressure (ΔP)Definition: ΔP = Pplat − PEEP.Reflects: Pressure needed to keep alveoli open during the respiratory cycle.Goal: Lower ΔP → less atelectrauma & improved outcomes.Optimize: Increase PEEP to reduce ΔP and alveolar cycling. 📖 Interpreting High PIP/High Pplat ↑ PIP & ↑ PplatInterpretation: ↓ ComplianceCommon Causes: ARDS, pulmonary edema, pleural effusion, pneumothorax↑ PIP & Normal/Low PplatInterpretation: ↑ Airway ResistanceCommon Causes: Mucus plug, bronchospasm, tube obstruction or biting 🤕 Ventilator-Associated Lung Injury (VILI) Barotrauma:Mechanism: Excessive airway pressure damages alveoli.Prevention: Keep Pplat < 30 cmH₂O.Volutrauma:Mechanism: Overdistension from excessive tidal volumes.Prevention: Use low tidal volume ventilation (6 mL/kg ideal body weight).ARDSNet trial: 6 mL/kg → lower mortality compared to 12 mL/kg.Ideal Body Weight: Based on height and sex, not actual weight.Typical patient: Tidal Volume: 6–8 mL/kg IBWARDS: Tidal Volume: 4–6 mL/kg IBWAtelectrauma:Mechanism: Repeated opening/collapse of unstable alveoli.Prevention: Optimize PEEP to keep alveoli open and reduce driving pressure.Biotrauma:Mechanism: Inflammatory cascade (↑ IL-6, TNF-α) from mechanical injury.Effect: Can trigger systemic inflammation & multiorgan dysfunction.Prevention: Minimize all other forms of VILI. Post Peer Reviewed By: Marco Propersi, DO (Twitter/X: @Marco_propersi), and Mark Ramzy, DO (X: @MRamzyDO) 👤 Show Notes Joel Rios Rodriguez, MD PGY 3 Internal Medicine Resident Cape Fear Valley Internal Medicine Residency Program Fayetteville NC Aspiring Pulmonary Critical Care Fellow 🔎 Your Deep-Dive Starts Here REBEL Core Cast – Pediatric Respiratory Emergencies: Beyond Viral Season Welcome to the Rebel Core Content Blog, where we delve ... Pediatrics Read More REBEL Core Cast 143.0–Ventilators Part 3: Oxygenation & Ventilation — Mastering the Balance on the Ventilator When you take the airway, you take the wheel and ... Thoracic and Respiratory Read More REBEL Core Cast 142.0–Ventilators Part 2: Simplifying Mechanical Ventilation – Most Common Ventilator Modes Mechanical ventilation can feel overwhelming, especially when faced with a ... Thoracic and Respiratory Read More REBEL Core Cast 141.0–Ventilators Part 1: Simplifying Mechanical Ventilation — Types of Breathes For many medical residents, the ICU can feel like stepping ... Thoracic and Respiratory Read More REBEL Core Cast 140.0: The Power and Limitations of Intraosseous Lines in Emergency Medicine The sicker the patient, the more likely an IO line ... Procedures and Skills Read More REBEL Core Cast 139.0: Pneumothorax Decompression On this episode of the Rebel Core Cast, Swami takes ... Procedures and Skills Read More The post REBEL Core Cast 147.0–Ventilators Part 5: Key Mechanical Ventilator Pressures & Definitions Made Simple appeared first on REBEL EM - Emergency Medicine Blog.

Machine Learning Street Talk
Making deep learning perform real algorithms with Category Theory (Andrew Dudzik, Petar Velichkovich, Taco Cohen, Bruno Gavranović, Paul Lessard)

Machine Learning Street Talk

Play Episode Listen Later Dec 22, 2025 43:57


We often think of Large Language Models (LLMs) as all-knowing, but as the team reveals, they still struggle with the logic of a second-grader. Why can't ChatGPT reliably add large numbers? Why does it "hallucinate" the laws of physics? The answer lies in the architecture. This episode explores how *Category Theory* —an ultra-abstract branch of mathematics—could provide the "Periodic Table" for neural networks, turning the "alchemy" of modern AI into a rigorous science.In this deep-dive exploration, *Andrew Dudzik*, *Petar Velichkovich*, *Taco Cohen*, *Bruno Gavranović*, and *Paul Lessard* join host *Tim Scarfe* to discuss the fundamental limitations of today's AI and the radical mathematical framework that might fix them.TRANSCRIPT:https://app.rescript.info/public/share/LMreunA-BUpgP-2AkuEvxA7BAFuA-VJNAp2Ut4MkMWk---Key Insights in This Episode:* *The "Addition" Problem:* *Andrew Dudzik* explains why LLMs don't actually "know" math—they just recognize patterns. When you change a single digit in a long string of numbers, the pattern breaks because the model lacks the internal "machinery" to perform a simple carry operation.* *Beyond Alchemy:* deep learning is currently in its "alchemy" phase—we have powerful results, but we lack a unifying theory. Category Theory is proposed as the framework to move AI from trial-and-error to principled engineering. [00:13:49]* *Algebra with Colors:* To make Category Theory accessible, the guests use brilliant analogies—like thinking of matrices as *magnets with colors* that only snap together when the types match. This "partial compositionality" is the secret to building more complex internal reasoning. [00:09:17]* *Synthetic vs. Analytic Math:* *Paul Lessard* breaks down the philosophical shift needed in AI research: moving from "Analytic" math (what things are made of) to "Synthetic" math [00:23:41]---Why This Matters for AGIIf we want AI to solve the world's hardest scientific problems, it can't just be a "stochastic parrot." It needs to internalize the rules of logic and computation. By imbuing neural networks with categorical priors, researchers are attempting to build a future where AI doesn't just predict the next word—it understands the underlying structure of the universe.---TIMESTAMPS:00:00:00 The Failure of LLM Addition & Physics00:01:26 Tool Use vs Intrinsic Model Quality00:03:07 Efficiency Gains via Internalization00:04:28 Geometric Deep Learning & Equivariance00:07:05 Limitations of Group Theory00:09:17 Category Theory: Algebra with Colors00:11:25 The Systematic Guide of Lego-like Math00:13:49 The Alchemy Analogy & Unifying Theory00:15:33 Information Destruction & Reasoning00:18:00 Pathfinding & Monoids in Computation00:20:15 System 2 Reasoning & Error Awareness00:23:31 Analytic vs Synthetic Mathematics00:25:52 Morphisms & Weight Tying Basics00:26:48 2-Categories & Weight Sharing Theory00:28:55 Higher Categories & Emergence00:31:41 Compositionality & Recursive Folds00:34:05 Syntax vs Semantics in Network Design00:36:14 Homomorphisms & Multi-Sorted Syntax00:39:30 The Carrying Problem & Hopf FibrationsPetar Veličković (GDM)https://petar-v.com/Paul Lessardhttps://www.linkedin.com/in/paul-roy-lessard/Bruno Gavranovićhttps://www.brunogavranovic.com/Andrew Dudzik (GDM)https://www.linkedin.com/in/andrew-dudzik-222789142/---REFERENCES:Model:[00:01:05] Veohttps://deepmind.google/models/veo/[00:01:10] Geniehttps://deepmind.google/blog/genie-3-a-new-frontier-for-world-models/Paper:[00:04:30] Geometric Deep Learning Blueprinthttps://arxiv.org/abs/2104.13478https://www.youtube.com/watch?v=bIZB1hIJ4u8[00:16:45] AlphaGeometryhttps://arxiv.org/abs/2401.08312[00:16:55] AlphaCodehttps://arxiv.org/abs/2203.07814[00:17:05] FunSearchhttps://www.nature.com/articles/s41586-023-06924-6[00:37:00] Attention Is All You Needhttps://arxiv.org/abs/1706.03762[00:43:00] Categorical Deep Learninghttps://arxiv.org/abs/2402.15332

Pursuit Church of the Nazarene
PRESENT | Part 3

Pursuit Church of the Nazarene

Play Episode Listen Later Dec 22, 2025 28:51


Limitations in our lives can be a gift when we surrender to God's purposes. Key Scriptures: Luke 1:26-38 NLT; 2 Corinthians 12:8-10 NLT Connect with us & let us know you are listening and how we can pray for you... https://www.pursuitnazarene.org/online-connection-card

Rare Disease Discussions
Chapter 5: Current Treatment Landscape and Limitations

Rare Disease Discussions

Play Episode Listen Later Dec 21, 2025 9:01


Nicola Longo MD, PhD, and Mark Roberts, MDDrs. Longo and Roberts discuss the current status of gene therapies in rare neuromuscular disorders in this eight-part podcast series. This is derived from the symposium that was presented at WORLDSymposium 2025 in San Diego, California on February 4th-7th 2025 and is intended for healthcare professionals only.This podcast includes information about investigational compounds that do not yet have a regulatory approval or authorization for a specific indication. The safety and efficacy of the agents under investigation have not been established and contents of this podcast shall not be used in any manner to directly or indirectly promote or sell the product for unapproved uses.The views, thoughts, and opinions expressed in this presentation belong solely to the author and are subject to change without notice. The contents of this presentation do not constitute an endorsement of any product or indication by Astellas. In this part, Dr. Longo will discuss the current treatment landscape and limitations in lysosomal disorders.Nicola Longo MD, PhDWhat I want to do today, is just place gene replacement therapy within the current landscape of lysosomal storage disorder treatment therapy. Gene therapy obviously has the potential of treating lysosomal disorder to correct the root cause of lysosomal storage disorder. The gene is defective, and what happen is that you can potentially either fix the gene or bypass the lack of the genetic product. But there are already therapies that are existing and are functioning. Obviously, in many cases, the lysosomal disorder is caused by defective production of an enzyme, which is defective.We can either replace the enzyme with enzyme replacement therapy, or provide chaperone for specific mutations that retain the synthesis of the enzyme, that however is not very functional. Another avenue that it is being reported is the utilization of substrate reduction therapy. A substrate accumulates, you prevent the synthesis of the substrate to reduce the accumulation of toxic material. What we know now is that this is not enough to produce many lysosomal disorders. In many cases, the lysosomal disorder result sometime in impairment of intracellular trafficking, and sometime in the function of other organelles.At the end, it results in the activation of the macrophagic system and inflammation. Already we have some therapy acting at this level. The end result of lysosomal storage disorder, there will be cell suffering and cell death, leading to a progression of the disease, and morbidity and mortality. Now, what therapy do we have available already? Obviously, hematopoietic stem cell transplantation has been around for quite some time.It has been the same thing that we do with gene therapy, except that instead of reintroducing the gene of the subject, we place gene of a subject who is not affected of the disease. This therapy has been proven effective in cases of MPS-1 and alpha-mannosidosis. But in many cases this has to be given way before symptoms start to be affected.Enzyme replacement therapy has been around for quite some time, starting with Gaucher disease, and now that it is available for a list of diseases that are there, so it's like Fabry, Gaucher, Pompe, different types of mucopolysaccharidosis, alpha-mannosidosis, acid lipase deficiency, 1 neuronal ceroid lipofuscinosis, and Niemann-Pick type A and B.Obviously the advantage of this therapy, they give back the enzyme that it is defective. But the disadvantage that many time they cannot enter specialized areas such as the brain. There is already the second generation of enzyme replacement therapy that it is available. With this second generation, some of the newer drugs are more effective in terms of cellular uptake, or in terms of having a prolonged half-life and prolonged activity.Then there are pharmacological chaperone therapy, and the one which is FDA approved is migalastat for Fabry disease, under study is ambroxol for Gaucher disease. The disadvantage of this therapy that only a selected number of mutations respond to this therapy.Substrate reduction therapy has been introduced for Gaucher disease many years ago with miglustat, and it was followed by eliglustat. Both of them are effective, and some of them more effective than other, simply because of the fewer side effects of eliglustat as compared to miglustat. But at the same time, eliglustat does not pass the blood brain barrier.Finally, the newer agents that are already administered, N-acetyl-L-leucine and arimoclomol, both approved for Niemann-Pick type C, they act more on the downstream effect of the lysosomal storage disorder, either by stabilizing neuronal cell activity or by reducing the inflammation that is present in the brain.In the next part, Dr. Longo will discuss gene replacement therapy in lysosomal disorders.

Pursuit Church of the Nazarene
PRESENT | PART 3

Pursuit Church of the Nazarene

Play Episode Listen Later Dec 21, 2025 28:00


Limitations in our lives can be a gift when we surrender to God's purposes. Key Scriptures: Luke 1:26-38 NLT; 2 Corinthians 12:8-10 NLT Connect with us & let us know you are listening and how we can pray for you... https://www.pursuitnazarene.org/online-connection-card

This Week in Cardiology
Dec 19 2025 This Week in Cardiology

This Week in Cardiology

Play Episode Listen Later Dec 19, 2025 35:37


The MI paradox of risk scores, the CELEBRATE trial of a new subcutaneous glycoprotein IIb/IIIA inhibitor (with its funny endpoint), the SURPASS CVOT trial, and the bad story of andexanet alfa are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I What do risk scores mean for individuals? Or perhaps a better question: Is a first MI preventable? Limitations of Screening in Predicting First MI https://www.jacc.org/doi/10.1016/j.jacadv.2025.102361 Sudden Death Due to Cardiac Arrhythmias https://www.nejm.org/doi/abs/10.1056/NEJMra000650 UMC Amsterdam group (EHJ) https://academic.oup.com/eurheartj/article/46/38/3762/8181058 II CELEBRATE Trial CELEBRATE Trial https://evidence.nejm.org/doi/full/10.1056/EVIDoa2500268 III SURPASS CVOT Trial Published Aug 01, 2025 This Week in Cardiology Podcast https://www.medscape.com/viewarticle/1002781 SURPASS-CVOT Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2505928 REWIND Trial 10.1016/S0140-6736(19)31149-3 External Link IV FDA Pulls Andexanet Alfa From the Market ANNEXA 4 https://www.nejm.org/doi/10.1056/NEJMoa1814051 ANNEXA I https://www.nejm.org/doi/full/10.1056/NEJMoa2313040 Richard Buka Tweet https://x.com/richardbuka/status/2001045834050216327?s=20 V Mandrola's Top Cardiovascular Stories of 2025 https://www.medscape.com/viewarticle/mandrolas-top-10-cardiovascular-stories-2025-2025a1000yuh You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

Empirical Cycling Podcast
Watts Doc #60: Durability's Limitations

Empirical Cycling Podcast

Play Episode Listen Later Dec 18, 2025 152:46


We take a deep dive into the published literature on durability. First a critical look at the paper coining the term, the next establishing a widely used measurement, and another on the definition and differentiation of several aspects of endurance performance. Then discussing aspects of measurement and trainability, plus the relative statistical strength in the literature vs typical interpretations. Finally some advice from coaching experience, and answering your listener questions.

OSHA 30/30 and TSCA 30/30
ALJ Addresses Six-Month Limitations Defense

OSHA 30/30 and TSCA 30/30

Play Episode Listen Later Dec 18, 2025 26:15


Keller and Heckman Partner Manesh Rath hosts OSHA 30/30, a webinar series that covers OSHA issues for 30 minutes every 30 days. Mr. Rath is a trial and appellate attorney with experience in general commercial litigation, wage and hour and class action litigation, occupational safety and health (OSHA) law, labor law, and employment law. This month's topic: ALJ Addresses Six-Month Limitations Defense

Relationship Chronicles
Episode 680 The Still Syndrome

Relationship Chronicles

Play Episode Listen Later Dec 18, 2025 20:21 Transcription Available


Most people are stuck in the still syndrome and have been there for years! If you don't change, neither will your situation. Still, still, still only keeps you in the same mindset doing the same old things, the same old way! It's called a repetitive cycle and it's how most people live their lives on auto pilot! You're the only one who can change it! It's a form of consistency but not a beneficial form!Become a supporter of this podcast: https://www.spreaker.com/podcast/relationships-and-relatable-life-chronicles--4126439/support.

In The Tranches of Structured Finance
Consumer Credit Check-In: Vintages, Prepayments, and Investor Signals

In The Tranches of Structured Finance

Play Episode Listen Later Dec 17, 2025 38:00


In this episode of In the Tranches of Structured Finance, Vadim addresses follow-up questions from dv01's recent consumer credit webinar and provides an updated view on consumer credit performance across key markets—focusing on what the data is actually signaling for investors.Key themes include:Late-2024 consumer unsecured vintages: Why early performance comparisons—especially across credit tiers—require nuance and patiencePrepayments and returns: How elevated prepayments are distorting delinquencies and ROI, and why IRR remains the more reliable lensData quality and interpretation: Limitations of bureau-based reporting and the importance of loan-level analysisPrivate credit: Why its growing role does not make markets more opaqueMarket performance update: Consumer unsecured strength versus continued pressure in Non-QM, with losses remaining containedThis episode is designed for market participants looking to move beyond headlines and better understand the forces shaping consumer credit performance today.Subscribe to our free research to stay up-to-date on the latest trends. Contact sales@dv01.co to learn how dv01 data can help you understand what's going on in the market, and to better analyze your whole loan portfolio and securitizations.

Bricks & Bytes
B&B Fight Night: Has AI Solved Estimating? Mike Powers Vs Luigi La Corte

Bricks & Bytes

Play Episode Listen Later Dec 17, 2025 75:20


The UFC arrives in AEC. And we're live from the AEC Octagon.In the very first episode of our brand-new Bricks & Bytes Debates series, we are trading PR statements for sparring gloves. We're putting two industry heavyweights head-to-head to battle out one of the hottest topics in construction: Has AI actually solved estimating?In this no-holds-barred contester series, our contenders took the gloves off to represent the extreme Bull and Bear cases for Artificial Intelligence:• In the Red Corner: Mike "Mighty" Powers (Co-Founder, BuildVision), arguing that LLMs have solved the extraction problem and the industry needs to embrace the "Waymo" era of automation.• In the Blue Corner: Luigi "The Stinger" La Corte (Co-Founder, Provision), arguing that estimating is more than just counting symbols - and that without 100% accuracy, AI is still just a student driver.Moderated by the referee of reason, Patric "Praying For Exits" Hellermann, this debate moves through three grueling rounds: - Round 1: The Tech. Can LLMs actually count and measure complex drawings, or are they just guessing? - Round 2: The Accuracy Gap. Is 80% accuracy "good enough" to change the industry, or is "trust but verify" just a nice way of saying "do it yourself"? - Round 3: The Liability. In a world of design-bid-build, who takes the fall when the AI misses a scope gap? Tune in to uncover:• The "Waymo" Strategy: Why waiting for perfect AI is a mistake, and how to leverage the "self-driving" mindset to reduce takeoff times by 90% today.• The Hidden Liability Loophole: Why architects and engineers could solve the estimating crisis instantly by sharing models—and the legal reason they never will.• Symbols vs. Language: Learn the fundamental technical limitation preventing LLMs from reading 2D drawings like a human, and when we can expect "Visual Language Models" to catch up.• The Subcontractor's Dilemma: Why "Design Intent" matters more than counting linear feet, and why subs might actually be wasting time on granular takeoffs.• A "Bribe" for Better Data: One listener's hilarious (but practical) suggestion for how to finally get the Revit model from the design team.Who will deliver the knockout punch? Tune in to decide for yourself.Chapters 00:00 Intro01:48 Introduction to Bricks and Bytes Debates 04:07 Opening Statements and Context Setting 06:51 Technical Feasibility of AI in Estimating 09:57 Practical Applications and Limitations of AI 12:59 Customer Expectations and Accuracy in AI Solutions 15:57 The Role of Human Oversight in AI Estimation 18:43 Future of AI in Construction Estimation 38:23 Navigating the Self-Driving Debate 41:19 The Evolution of AI in Estimating 43:32 Trust and Liability in Construction 46:13 The Role of Liability in AI Adoption 49:22 The Future of Estimators in AI 53:34 Rebuttals and Admissions: A Critical Discussion 59:39 The Current State of AI in Estimating

Joe Rose Show
Tua's Limitations Highlight Dolphins' Roster Issues

Joe Rose Show

Play Episode Listen Later Dec 16, 2025 17:18


Joe breaks down the bigger picture for the Dolphins, stressing that the team needs to learn how to close out games, especially late in the season. He points out that in the AFC East, Miami is still “a zillion miles away” from the Patriots and Bills, often getting exposed in cold-weather matchups. Joe argues the roster needs upgrades and questions whether Tua Tagovailoa truly gives the team the best chance to win, highlighting moments where the offense failed to read defenses effectively.

Love Is Stronger Than Fear
Christmas and the Hospitality of Need with Kevan Chandler

Love Is Stronger Than Fear

Play Episode Listen Later Dec 16, 2025 47:33 Transcription Available


S9 E6 — In a season of parties and entertaining, it's good to remember that hospitality means something very different—welcoming the stranger and caring for one another. In The Hospitality of Need, Kevan Chandler, born with a progressive disability, explores how dependence can expand life and deepen community. His story points us back to our shared human neediness, reflected in the baby lying in the manger. 00:0 Reimagining the Good Life06:12 Gift of Interdependence12:52 Understanding Need and Hospitality17:37 Proximity and Need21:43 Peer to Peer Caregiving26:39 A Journey to Skellig Michael32:53 Spiritual Realities of Need38:12 Invitation Into NeedMENTIONED IN THIS EPISODE:Amy Julia's interview with Kevan on Take the Next StepThe Hospitality of Need: How Depending on One Another Helps Us Heal and Grow Together by Kevan Chandler and Tommy SheltonWe Carry Kevan I John 1_WATCH this conversation on YouTube: Amy Julia Becker on YouTubeSUBSCRIBE to Amy Julia's Substack: amyjuliabecker.substack.comJOIN the conversation on Instagram: @amyjuliabeckerLISTEN to more episodes: amyjuliabecker.com/shows/_ABOUT OUR GUEST:KEVAN CHANDLER is the founder of the nonprofit organization We Carry Kevan and speaks worldwide about friendship and disability. He and his wife, Katie, enjoy doing everything together, including growing vegetables and reading to each other.Kevan was the second of his siblings to be diagnosed with spinal muscular atrophy, type 2, a rare neuromuscular disease. In 2016, he and his friends took a trip across Europe, leaving his wheelchair at home, and his friends carried him for three weeks in a backpack.An avid storyteller, Kevan is an author and speaker worldwide about his friendships and unique life with a disability, being a featured speaker for Tedx and Google, as well as various conferences, pharmaceutical companies, and universities.__We want to hear your thoughts. Send us a text!Connect with me: Instagram Facebook YouTube Website Thanks for listening!

Going anti-Viral
The Role of Outcomes Research on Clinical Decisions for Patient Care – Dr Mari Kitahata

Going anti-Viral

Play Episode Listen Later Dec 16, 2025 37:40


In episode 63 of Going anti-Viral, Dr Mari Kitahata joins host Dr Michael Saag to discuss the role of outcomes research on clinical decisions for patient care. Dr Kitahata is a Professor of Medicine at the University of Washington (UW) in the Division of Allergy and Infectious Diseases. For more than 3 decades, she has directed the UW/Fred Hutch Center for AIDS Research (CFAR) Clinical Research Core. Dr Kitahata's research focuses on improving long-term outcomes for people with HIV and she has led studies demonstrating key determinants of increased survival in people with HIV including early initiation of antiretroviral therapy and care managed by physicians with greater HIV experience. Dr Kitahata discusses the significance of outcomes research in clinical settings, particularly in the context of HIV care. She explains the differences between efficacy and effectiveness, the challenges faced in observational studies, and the importance of statistical techniques to address biases. Dr Kitahata and Dr Saag discuss the role of electronic medical records (EMRs) in enhancing data collection and the necessity of data validation through adjudication processes. Additionally, the conversation touches on the importance of patient-reported outcomes and the limitations of EMR data, including issues of misclassification. Finally, Dr Saag and Dr Kitahata discuss the distinction between predictive modeling and etiologic modeling in research, underscoring the complexities of clinical care and the future directions for outcomes research.0:00 – Introduction2:30 – Efficacy versus effectiveness5:51 – Challenges in outcomes research8:27 – Statistical techniques in observational studies16:13 – The role of electronic medical records19:36 – Patient-reported outcomes and their importance22:18 – Data validation and adjudication28:30 – Limitations of observational data35:08 – The future of outcomes research __________________________________________________Produced by IAS-USA, Going anti–Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections. Going anti-Viral's host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. Email podcast@iasusa.org to send feedback, show suggestions, or questions to be answered on a later episode.Follow Going anti-Viral on: Apple Podcasts YouTubeXFacebookInstagram...

The Retail Razor Show
Consumer Insights - Can AI Reveal What Shoppers Really Want?

The Retail Razor Show

Play Episode Listen Later Dec 15, 2025 59:15


S5E13 Future of AI-Powered Consumer Insights with Trevor Sumner & Stan SthanunathanIn Season 5, Episode 13 of The Retail Razor Show, hosts Ricardo Belmar and Casey Golden tackle one of retail's biggest blind spots in consumer insights: the consumer sentiment gap. For decades, brands relied on surveys to understand shoppers. But what people say doesn't always match what they do.Enter AI-powered shopper insights!Joining the conversation are Trevor Sumner (CEO of i-Genie AI) and Stan Sthanunathan (Executive Chairman of i-Genie AI, former EVP at Unilever and VP at Coca-Cola). Together, they reveal how billions of unfiltered signals — from searches, reviews, and social posts — can be transformed into real-time, actionable consumer insights that reshape retail decision-making.What You'll Learn in This Episode:Why traditional consumer surveys are breaking downHow AI and natural language processing uncover real customer behaviorThe role of empathy vs sympathy in understanding consumersHow disruptor brands are reshaping competitive landscapesWhy augmented intelligence (AI + human insight) is the future of retail strategy and consumer insightsSubscribe to the Retail Razor Podcast Network: https://retailrazor.com/Subscribe to our Newsletter: https://retailrazor.substack.comSubscribe to our YouTube channel: https://bit.ly/RRShowYouTubeAbout our GuestsTrevor Sumner, CEO, i-Genie.AI - https://www.linkedin.com/in/trevorsumner/Trevor is a NYC-based entrepreneur, product and marketing executive and recognized startup advisor and angel. Trevor is the CEO at i-Genie.ai, the leading AI platform for consumer insights, revolutionizing an industry that had been dominated with antiquated survey methodologies by synthesizing tens of billions of searches, social and video posts, ratings and reviews and market data for industry leaders like Kenvue, Unilever, Coca-Cola, Bayer, Clorox and more.Previously, Mr. Sumner was Head of AI and Data Platform products for Raydiant, a leading VC-backed digital experience platform that is transforming over 250,000 digital touch points across 4,500 clients with AI, computer vision and data.Mr. Sumner came to Raydiant when it acquired Perch, a recognized leader in in-store Product Engagement Marketing, interactive retail displays and augmented reality, where Mr. SUmner served as CEO. Perch was named a Top Tech Company to Watch by Forbes, a Top 10 Retail Technology company by CIO Review and has won numerous Clio, Fast Company, Edison, Bloomberg and Digi awards.Stan Sthanunathan, Executive Chairman, i-Genie.AI - https://www.linkedin.com/in/stan-sthanunathan-1ab4035/Stan Sthanunathan joined Unilever in July 2013 as Executive Vice President of Consumer & Market Insights. As chief provocateur, he headed up the insights function globally based in London. He retired from Unilever on June 1, 2021.Post retirement he has started an AI/ML enabled company called i-Genie.AI focused on delivering near real time insights and ideas to help business identify Next Big Thing. Prior to joining Unilever, he was Vice President of Marketing Strategy & Insights for The Coca-Cola Company in Atlanta, heading up the function on a global basis.Stan co-authored a paper on Building an Insights Engine that was published in Harvard Business Review, Sept 2016. He has also co-authored a book titled AI for Marketing and Product Innovation.He was awarded Lifetime Achievement award at TMRE 2022 event.Chapters:00:00 Previews 01:23 Show Intro 04:43 The Consumer Sentiment Gap 05:37 Welcome Trevor Sumner & Stan Sthanunathan 06:30 Backgrounds of Trevor and Stan 09:11 Challenges in Understanding Consumers 16:58 The Evolution of Influencers 18:32 Limitations of Surveys and the Need for AI 25:46 Augmented Intelligence: AI + Human Insight 31:46 Challenges in CPG Innovation 33:02 Innovate: A Data-Driven Product 34:42 AI and Predictive Analytics 36:21 Democratizing Data Access 38:07 Mindset Shift for Rapid Actions 40:46 Adopting AI in CPG 48:16 Retailers and Data Utilization 52:59 Future of Brand Understanding 57:23 Conclusion and Contact Information 58:15 Show CloseMeet your hosts, helping you cut through the clutter in retail & retail tech:Ricardo Belmar is an NRF Top Retail Voices for 2025 & a RETHINK Retail Top Retail Expert from 2021 – 2025. Thinkers 360 has named him a Top 10 Retail, & AGI Thought Leader, a Top 50 Management, Transformation, & Careers Thought Leader, a Top 100 Digital Transformation & Agentic AI Thought Leader, plus a Top Digital Voice for 2024 and 2025. He is an advisory council member at George Mason University's Center for Retail Transformation, and the Retail Cloud Alliance. He was most recently the director partner marketing for retail & consumer goods in the Americas at Microsoft.Casey Golden, is CEO of Luxlock, a RETHINK Retail Top Retail Expert from 2023 - 2025, and a Retail Cloud Alliance advisory council member. Obsessed with the customer relationship between the brand and the consumer. After a career on the fashion and supply chain technology side of the business, now slaying franken-stacks and building retail tech! Currently, Casey is the North America Leader for Retail & Consumer Goods at CI&T.Includes music provided by imunobeats.com, featuring Overclocked, and E-Motive from the album Beat Hype, written by Heston Mimms, published by Imuno.

Ab 21 - Deutschlandfunk Nova
Immer noch Single - Wie komm ich mit dem Druck klar?

Ab 21 - Deutschlandfunk Nova

Play Episode Listen Later Dec 15, 2025 20:47


Saskia hatte noch nie eine "ernste" Beziehung, aber bisher auch nicht die innere Motivation etwas daran zu ändern. Die Gesellschaft diskriminiert Singles oft, sagt ein Soziologe. Was zu tun ist, wenn Druck von außen kommt, erklärt eine Therapeutin.**********Ihr hört: Gesprächspartnerin: Saskia, 29, hatte noch nie eine "richtige" Beziehung Gesprächspartner: Elyakim Kislev, Soziologe an der Hebräischen Universität Jerusalem, forscht zum Singlesein im 21. Jahrhundert Gesprächspartnerin: Julia Henchen, Paartherapeutin und Sexualtherapeutin Autor und Host: Przemek Żuk Redaktion: Grit Eggerichs, Anne Bohlmann, Friederike Seeger Produktion: Sonja Maronde**********Quellen:Kislev, E. (2023). Singlehood as an identity. European Review of Social Psychology, 35(2), 258–292.Kislev, E. (2021). The Sexual Activity and Sexual Satisfaction of Singles in the Second Demographic Transition. Sex Res Soc Policy 18, 726–738.Girme, Y. U., Park, Y., & MacDonald, G. (2022). Coping or Thriving? Reviewing Intrapersonal, Interpersonal, and Societal Factors Associated With Well-Being in Singlehood From a Within-Group Perspective. Perspectives on Psychological Science, 18(5), 1097-1120.Van den Berg, L. & Verbakel, E. (2022). Trends in singlehood in young adulthood in Europe. Advances in Life Course Research 15.Tessler, H. (2023). The stability of singlehood: Limitations of the relationship status paradigm and a new theoretical framework for reimagining singlehood. Journal of Family Theory & Review, 15(3), 444-464.**********Mehr zum Thema bei Deutschlandfunk Nova:Beziehungsmodell: Wie befreiend sind SituationshipsJungfrau mit 30: Warum setzt uns das erste Mal so unter Druck?Generation beziehungsunfähig: Autor Michael Nast im Interview**********Den Artikel zum Stück findet ihr hier.**********Ihr könnt uns auch auf diesen Kanälen folgen: TikTok und Instagram .**********Meldet euch!Ihr könnt das Team von Facts & Feelings über Whatsapp erreichen.Uns interessiert: Was beschäftigt euch? Habt ihr ein Thema, über das wir unbedingt in der Sendung und im Podcast sprechen sollen?Schickt uns eine Sprachnachricht oder schreibt uns per 0160-91360852 oder an factsundfeelings@deutschlandradio.de.Wichtig: Wenn ihr diese Nummer speichert und uns eine Nachricht schickt, akzeptiert ihr unsere Regeln zum Datenschutz und bei Whatsapp die Datenschutzrichtlinien von Whatsapp.

Elis James and John Robins
#497 - Badiography, Gunge Limitations and Snippy WhatsApps From The 1pm Bath

Elis James and John Robins

Play Episode Listen Later Dec 12, 2025 62:41


Today we ask the question: what would a world without Dave look like? A Daveless world. Imagine a sliding doors moment where a sterner producer was given the reins in 2014. Fast forward to late 2025 and in the studio, almost certainly, Elis would still be eating or have forgotten to come in. John would have vape hot boxed himself into a coma. Do not underestimate his impact.No Dave and no wise words of “Be careful Elis” after one presenter has deployed a “Is that it?!” to John's detailing his once every six months busy day.Around such questioning, John also unveils Craig Bellamy's autobiography (inc. typos) and a senior writer at Rolling Stone gets in touch. Elsewhere, there's news of more Noel Edmonds hysteria, quite significant gunge chat and a dead silly mad dad. Oh what are those dads like!Points of contact: elisandjohn@bbc.co.uk (Electronic mail) 07974 293 022 (WhatsApp)

OhSoSpurs Podcast
STOP BELIEVING ALL THE DATA! YOU Are Being Sold A Lie!

OhSoSpurs Podcast

Play Episode Listen Later Dec 12, 2025 28:04


In this episode of the OhSoSpurs podcast, Jim, Aaron, and JJ discuss the complexities and potential pitfalls of relying on data in football analysis. They explore how data visualisations, such as pass maps, can be misleading and fail to capture the full context of player interactions on the pitch. The conversation delves into the importance of combining data with observational insights, particularly in coaching and player evaluation. They also touch on the subjective nature of metrics like expected goals and the necessity of understanding the context behind statistics to make informed decisions in football. 00:00 - Intro 01:34 - The Limitations of Pass Maps 09:15 - The Problem with Wagon Wheels and Player Comparisons 14:12 - Understanding XG and Expected Threat 19:49 - The Importance of Context in Data Analysis Learn more about your ad choices. Visit podcastchoices.com/adchoices

We Study Billionaires - The Investor’s Podcast Network
BTC256: Bitcoin Market Sentiment and Liquidity Cycles w/ Andy Edstrom (Bitcoin Podcast)

We Study Billionaires - The Investor’s Podcast Network

Play Episode Listen Later Dec 10, 2025 60:10


Andy and Preston explore the turbulent world of Bitcoin treasury companies, from MicroStrategy's bold plays to sector-wide risks and poor performance. They dive into Bitcoin-backed stablecoins, valuation models, and adoption barriers. The episode wraps with discussions on energy, AI, and whether Bitcoin's market cycles are evolving toward stability or fresh volatility. IN THIS EPISODE YOU'LL LEARN: 00:00:00 - Intro 00:01:43 - Why many Bitcoin treasury companies have underperformed or failed 00:03:34 - How MicroStrategy's debt profile compares to its market cap and cash flow 00:06:59 - The concept of Bitcoin-backed stablecoins and their over-collateralization 00:08:58 - Key solvency risks in stablecoin issuance and Bitcoin securitization 00:14:46 - How valuation frameworks like MNAV apply to Bitcoin treasuries 00:19:26 - Limitations of MicroStrategy stock vs. holding Bitcoin directly 00:26:09 - Why Bitcoin adoption is hindered by complexity and public perception 00:29:18 - Andy's diversified investment strategy beyond Bitcoin 00:32:45 - How emerging AI and EV technologies intersect with financial trends 00:42:39 - Market cycle insights and predictions for Bitcoin's future price Disclaimer: Slight discrepancies in the timestamps may occur due to podcast platform differences.  BOOKS AND RESOURCES Andy Edstrom's Book: Why Buy Bitcoin: Investing Today in the Money of Tomorrow. X Account: Andy Edstrom. Check out all the books mentioned and discussed in our podcast episodes ⁠⁠⁠⁠here⁠⁠⁠. Enjoy ad-free episodes when you subscribe to our ⁠⁠⁠⁠Premium Feed⁠⁠⁠⁠. NEW TO THE SHOW? Join the exclusive ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠TIP Mastermind Community⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to engage in meaningful stock investing discussions with Stig, Clay, Kyle, and the other community members. Follow our official social media accounts: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠X (Twitter)⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ | ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠LinkedIn⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ | | ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ | ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Facebook⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ | ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠TikTok⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Check out our ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Bitcoin Fundamentals Starter Packs⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Browse through all our episodes (complete with transcripts) ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠here⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Try our tool for picking stock winners and managing our portfolios: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠TIP Finance Tool⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Enjoy exclusive perks from our ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠favorite Apps and Services⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Get smarter about valuing businesses in just a few minutes each week through our newsletter, ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠The Intrinsic Value Newsletter⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Learn how to better start, manage, and grow your business with the ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠best business podcasts⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. SPONSORSSupport our free podcast by supporting our sponsors: Simple Mining Human Rights Foundation Unchained HardBlock Linkedin Talent Solutions Public.com - see the full disclaimer here. Amazon Ads Alexa+ Shopify Vanta Onramp Abundant Mines Horizon Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://theinvestorspodcastnetwork.supportingcast.fm

1000 Hours Outsides podcast
1KHO 645: The Cost of Ignoring Our Limitations | Justin Whitmel Earley, The Body Teaches the Soul

1000 Hours Outsides podcast

Play Episode Listen Later Dec 9, 2025 54:44


Justin Whitmel Earley once believed he could outwork sleep, outrun stress, and think his way out of anxiety until his body forced him to face the truth. In this powerful return to The 1000 Hours Outside Podcast, Justin shares how a sudden collapse into panic, insomnia, and intrusive thoughts exposed the danger of living as if we are machines instead of human beings with God-given limits. Together, Justin and Ginny unpack the core message of his newest book, The Body Teaches the Soul—that many of our deepest struggles aren't solved by trying harder, but by relearning how to live inside the design of our bodies through breath, rest, rhythm, and habit. From box breathing and breath prayers to Sabbath, sleep, and the quiet power of daily “trellis habits,” this conversation brings theology down into the lungs, the nervous system, the dinner table, and the bedtime routine. You'll hear how limits are not a punishment but a gift and how ignoring them quietly erodes our peace, our families, and our faith. This episode is for anyone who feels stretched thin, chronically tired, or quietly anxious as well as for parents trying to pass something better to their children. Check out Justin's podcast here: https://www.intentionalfatherhood.org Get your copy of The Body Teaches the Soul here Learn more about your ad choices. Visit megaphone.fm/adchoices

James Elden's Playwright's Spotlight
Gatekeepers, Pushing the Line, Independent vs Mainstream, and the Limitations of Specificity - Playwright's Spotlight with Isaac Laskin

James Elden's Playwright's Spotlight

Play Episode Listen Later Dec 9, 2025 51:32


Send us a textIn this episode, musical theatre playwright Isaac Laskin stopped by Playwright's Spotlight to talk about the the development and evolution of his hit L.A. musical Hey, Morgan. He dispels the rumor of being challenged to write a musical about a dear friend, how the origination started as individual standalone songs about his roommate and how it later evolved into a musical. We unpack its growth from a short-run, small-theater production into a bigger, longer running show which included a copy of the soundtrack for the audience to leave with. We discuss the logistics of the cast album, writing multilayered/tracked songs, comedy in the current climate, pushing the envelope and crossing the line, and putting it out into the public for outside production. It's an inspiring conversation, where even the most simple concepts and turn into much more ambitious projects. Enjoy!Isaac Laskin is a musical playwright, actor, director, musician, and screenwriter. His hit musical Hey Morgan ran the LA circuit at The Attic Theater in January 2011 and made a revival at the Black Dalia Theatre from 2011 through 2012. He is a former English Teacher at the prestigious Harvard-Westlake Upper School in Los Angeles.To watch the video format of this episode, visit - https://youtu.be/IqpqINTDCfYLinks to sites and resources mentioned in this episode -The Geffen - https://www.geffenplayhouse.orgHey, Morgan on iTunes - https://music.apple.com/us/album/hey-morgan-original-cast-recording/1532877933Hey, Morgan on Spotify - https://open.spotify.com/artist/1wHV2oNiYxDpAgt68w9IYV?si=YIsPEbaVQ5WvlkbHzpsyKQThe Lincoln Bedroom on iTunes - https://music.apple.com/us/album/broken-record/1493495387Websites and socials for James Elden, PMP, and Playwright's Spotlight -Punk Monkey Productions - www.punkmonkeyproductions.comPLAY Noir -www.playnoir.comPLAY Noir Anthology –www.punkmonkeyproductions.com/contact.htmlJames Elden -Twitter - @jameseldensauerIG - @alakardrakeFB - fb.com/jameseldensauerPunk Monkey Productions and PLAY Noir - Twitter - @punkmonkeyprods                  - @playnoirla IG - @punkmonkeyprods       - @playnoir_la FB - fb.com/playnoir        - fb.com/punkmonkeyproductionsPlaywright's Spotlight -Twitter - @wrightlightpod IG - @playwrights_spotlightPlaywriting services through Los Angeles Collegiate Playwrights Festivalwww.losangelescollegiateplaywrightsfestival.com/services.htmlSupport the show

Total Information AM
Supreme Court will weigh-in on the reach or limitation of Presidential power to fire agency heads

Total Information AM

Play Episode Listen Later Dec 9, 2025 5:50


CBS Legal Analyst Thane Rosenbaum joins Megan Lynch as the Supreme Court is taking up a case regarding the firing of a member of the FTC. Rosenbaum says that while listening to the arguments, he thinks SCOTUS is, 'willing to say the President has power to make these hiring or firing decisions,' but may decide differently in an upcoming case involving a member of the Federal Reserve. He says there is no evidence in any of these decisions are based on 'cause', more so that they are just President Trump's decision.

Ever Forward Radio with Chase Chewning
EFR 913: Why GLP-1 Medications Work (and When They Don't): The Hidden Hormone Story Behind Ozempic & Wegovy with Ashley Koff

Ever Forward Radio with Chase Chewning

Play Episode Listen Later Dec 8, 2025 99:20


This episode is brought to you by Joi & Blokes, Troscriptions, and Caldera Lab. In this episode of Ever Forward Radio, registered dietitian Ashley Koff, RD breaks down the truth behind GLP-1 medications like Ozempic and Wegovy, reframing them not as magic weight-loss shots but as hormone replacement therapies that reveal how dysfunctional most people's "weight-health hormones" have become. Ashley shares how digestion, nutrient status, genetics, and modern environmental pressures diminish the body's natural ability to regulate appetite, cravings, metabolism, and fat distribution — and why GLP-1 drugs can offer clarity but not a cure unless the underlying issues are addressed. She dives into muscle preservation, the limitations of BMI, the importance of fat-mass vs. scale weight, the root-cause approach to sustainable weight health, and what the future of GLP-1s means for generational wellness. This is a powerful conversation that blends science, personal insight, and actionable strategies to improve metabolic health — with or without medication. Follow Ashley @ashleykoffapproved Follow Chase @chase_chewning ----- 00:00 – GLP-1 hype: weight loss, risks, and whole-body benefits 02:00 – What GLP-1 drugs actually do in the body 02:20 – Understanding "weight-health hormones" 03:00 – Why society is functioning with suboptimal hormones 12:00 – Why total weight doesn't matter — muscle, fat, and bone do 14:00 – BMI is broken and misleading 15:00 – Weight regain, muscle loss, and metabolism 17:00 – Genetics, survival traits, and appetite regulation 23:00 – Root-cause approach: digestion, nutrient status, vagus nerve work 26:00 – How GLP-1s validate hormone dysfunction 28:00 – Side effects like nausea and constipation explained 30:00 – Why digestive repair is essential for long-term success 33:00 – How GLP-1s quiet obsessive thoughts, cravings, and food noise 36:00 – Supplements that support GLP-1 and weight-health hormone function 38:00 – Hop extract research and natural "GLP-1 activators" 42:00 – Limitations of natural alternatives vs. true hormone replacement 1:12:00 – Glucose spikes, CGMs, and metabolic flexibility 1:27:00 – The future of GLP-1s and redefining "obesity" 1:28:00 – Generational weight health and epigenetics 1:29:00 – Final thoughts and Ashley's Ever Forward message ----- Episode resources: Get 50% off any diagnostic labs with code CHASE at https://www.JoiAndBlokes.com/chase  Try CALM and save with checkout code EVERFORWARD at https://www.Troscriptions.com/everforward  Get 20% off the best men's skincare with code EVERFORWARD at https://www.CalderaLab.com  Watch and subscribe on YouTube Get Ashley's book on Amazon

REBEL Cast
REBEL Core Cast 146.0–Ventilators Part 4: Setting up the Ventilator

REBEL Cast

Play Episode Listen Later Dec 8, 2025 19:06


🧭 REBEL Rundown 🗝️ Key Points ❌ Don’t chase perfect numbers: Adequate and safe is often better than “perfect but harmful.”💨 Oxygenation levers: Start with FiO₂ and PEEP, but remember MAP is the true driver.🫁 Ventilation levers: Adjust RR and TV, tailored to underlying physiology.🚫 Watch your obstructive patients: Sometimes less RR is more. Click here for Direct Download of the Podcast. 📝 Introduction Ventilator management can feel overwhelming—there are so many knobs to turn, numbers to watch, and changes to make. But before adjusting any settings, it’s crucial to understand why the patient is in distress in the first place, because the right strategy depends on the underlying cause. In this episode, we’ll walk through three different cases to see how the approach changes depending on the problem at hand. ️ The 4 Main Ventilator Settings Tidal Volume (Vt) 🌬️ Amount of air delivered with each breath Typically set based on ideal body weight (6–8 mL/kg for lung protection) Respiratory Rate (RR) ⏱️ Number of breaths delivered per minute Adjusted to control minute ventilation and manage CO₂ FiO₂ (Fraction of Inspired Oxygen) ⛽ Percentage of oxygen delivered Adjusted to maintain adequate oxygenation (goal SpO₂ 92–96%, PaO₂ 55–80 mmHg). PEEP (Positive End-Expiratory Pressure) 🎈 Pressure maintained in the lungs at the end of exhalation to prevent alveolar collapse and improve oxygenation 🧮 Modes of Ventilation AC/VC (Assist Control – Volume Control)How it Works: Delivers a set tidal volume with each breath (whether patient- or machine-triggered).When It’s Used / Pros: Most common initial mode; guarantees minute ventilation; good for patients with variable effort.Limitations / Cons: May cause patient–ventilator dyssynchrony if set volumes don’t match patient’s demand.AC/PC (Assist Control – Pressure Control)How it Works: Delivers a set inspiratory pressure for each breath; tidal volume varies depending on lung compliance/resistance.When It’s Used / Pros: Useful in ARDS (lung-protective strategy), limits peak airway pressures.Limitations / Cons: Tidal volume not guaranteed; must closely monitor volumes and minute ventilation.PRVC (Pressure-Regulated Volume Control)How it Works: Hybrid: set target tidal volume, ventilator adjusts inspiratory pressure breath-to-breath to achieve it (within limits).When It’s Used / Pros: Common default mode on newer vents; combines benefits of VC (guaranteed volume) + PC (pressure limitation).Limitations / Cons: Can increase pressures if compliance worsens.SIMV (Synchronized Intermittent Mandatory Ventilation)How it Works: Delivers set breaths, but allows spontaneous patient breaths in between (without guaranteed volume).When It’s Used / Pros: Used for weaning; allows patient effort.Limitations / Cons: Risk of increased work of breathing if spontaneous breaths are inadequate.PSV (Pressure Support Ventilation)How it Works: Every breath is patient-initiated; ventilator provides preset pressure support to overcome airway resistance.When It’s Used / Pros: Weaning trials; patients with intact drive who just need assistance.Limitations / Cons: Not a full-support mode; not for unstable patients without spontaneous drive. ♟️ Ventilation Strategies Airway ProtectionLow GCS, seizure, strokeLoss of gag/cough reflexHigh aspiration risk (vomiting, GI bleed, poor mental status)Hypoxemic Respiratory FailureSevere pneumoniaARDSPulmonary edemaInhalation injuryVentilatory (Hypercapnic) Failure / Increased Ventilation DemandSevere metabolic acidosis (DKA, sepsis, renal failure) → need high minute ventilationCOPD, asthma (if decompensating)Neuromuscular weakness (myasthenia, Guillain–Barré, spinal cord injury)Airway Obstruction / Anticipated Loss of AirwayTumor, anaphylaxis, angioedemaFacial or airway traumaPre-op / anticipated deterioration Post Peer Reviewed By: Marco Propersi, DO (Twitter/X: @Marco_propersi), and Mark Ramzy, DO (X: @MRamzyDO) 👤 Show Notes Priyanka Ramesh, MD PGY 1 Internal Medicine Resident Cape Fear Valley Internal Medicine Residency Program Fayetteville NC Aspiring Pulmonary Critical Care Fellow 🔎 Your Deep-Dive Starts Here REBEL Core Cast – Pediatric Respiratory Emergencies: Beyond Viral Season Welcome to the Rebel Core Content Blog, where we delve ... Pediatrics Read More REBEL Core Cast 143.0–Ventilators Part 3: Oxygenation & Ventilation — Mastering the Balance on the Ventilator When you take the airway, you take the wheel and ... Thoracic and Respiratory Read More REBEL Core Cast 142.0–Ventilators Part 2: Simplifying Mechanical Ventilation – Most Common Ventilator Modes Mechanical ventilation can feel overwhelming, especially when faced with a ... Thoracic and Respiratory Read More REBEL Core Cast 141.0–Ventilators Part 1: Simplifying Mechanical Ventilation — Types of Breathes For many medical residents, the ICU can feel like stepping ... Thoracic and Respiratory Read More REBEL Core Cast 140.0: The Power and Limitations of Intraosseous Lines in Emergency Medicine The sicker the patient, the more likely an IO line ... Procedures and Skills Read More REBEL Core Cast 139.0: Pneumothorax Decompression On this episode of the Rebel Core Cast, Swami takes ... Procedures and Skills Read More The post REBEL Core Cast 146.0–Ventilators Part 4: Setting up the Ventilator appeared first on REBEL EM - Emergency Medicine Blog.

MoneyWise on Oneplace.com
Finding Hope in the Hard Things with Katherine Wolf

MoneyWise on Oneplace.com

Play Episode Listen Later Dec 8, 2025 24:57


When hope is tied only to a desired outcome, disappointment becomes inevitable. Katherine Wolf knows this truth more personally than most. At just 26, with a newborn in her arms and a lifetime ahead of her, she suffered a massive and unexpected stroke that changed everything.Today, through her writing, speaking, and nonprofit ministry Hope Heals, Katherine invites others into a deeper, sturdier hope—one that can withstand even the darkest valleys.On today's show, she joins us to share her journey: how suffering reshaped her faith, her understanding of God's goodness, and even her family's finances.A Life Forever ChangedIn 2008, without warning or symptoms, Katherine experienced a catastrophic brainstem stroke caused by a congenital condition she never knew she had—an arterial venous malformation (AVM). Overnight, she went from fully able-bodied to fighting for her life.A 16-hour surgery saved her, but her new reality included significant impairments. Today, she uses a wheelchair, has facial paralysis, reduced function in her right hand, and additional physical limitations. Still, she radiates joy and purpose.“I did live—and I'm doing great,” she says with her trademark resilience.Katherine describes the stroke as the moment “the pebble hit the metal”—a collision between everything she had learned about Jesus and the hardest chapter of her life.Years of Scripture, sermons, prayer, and discipleship prepared her for a moment she never imagined. “This is no longer a drill,” she remembers telling herself. Her long walk with Christ, though imperfect, had built a foundation strong enough to stand when everything else fell apart.In her memoir Hope Heals, she writes that suffering is not the end of the story—but the beginning of a new one. Christian hope does not deny pain; it declares that pain will not have the final word.Katherine's more recent book, Treasures in the Dark, draws from Isaiah 45:3—God's promise to give “hidden treasure” in the shadows of our lives so we might know Him more deeply.“If we must walk through darkness—and we all do at some point—why not gather the treasure God has placed there?” she asks. In other words, don't waste your pain. Let God use it to form you, deepen you, and show you His faithfulness in ways comfort never could.Hope Heals: A Ministry Born from SufferingOne of the greatest treasures to emerge from Katherine's hardship is Hope Heals, the nonprofit she and her husband, Jay, founded.Hope Heals CampTheir flagship outreach is a fully scholarship-supported summer camp for families affected by disability. Guests experience rest, community, and the love of Christ through what Katherine calls “inter-ability community”—people with and without disabilities sharing life together.Volunteers and families leave forever changed. The joy is contagious.Mend Coffee ShopIn Atlanta's Buckhead neighborhood, Hope Heals also operates Mend, a universally accessible coffee shop that employs people with disabilities and creates a space where everyone belongs.Katherine describes both initiatives as “glorious,” a word she uses often—and always with delight.The Financial Realities of SufferingMedical crises don't just affect the body; they often reshape a family's finances. Katherine knows this firsthand.When disability or sudden illness enters a story, she notes, “the finances can be ravaged.” Many families drain savings, take on debt, or scramble to fund treatments and therapies.But Katherine also speaks about “invisible wheelchairs”—the unseen burdens that hold people back. Financial instability, she says, can be one of the most crippling.Her encouragement? Everyone carries some kind of hardship. You are not alone. God gives us community and wisdom so we don't walk these valleys in isolation.For Katherine, surrender has become a central theme of her spiritual life, including how she views money.“Surrender is relief,” she says. “It's not God binding us up—it's letting Him take the wheel.”This posture doesn't magically erase financial challenges, but it reframes them. It anchors us in trust rather than fear. And it reminds us that provision comes from God, not our own strength.Hope for Anyone Facing UncertaintyKatherine's story speaks to those walking through overwhelming medical challenges—but her final encouragement reaches everyone, regardless of circumstances.Trusting God means you don't have to live afraid of what may happen next.Your circumstances may feel anything but okay, but when Christ lives in you, the deepest good in your life is already secure.“The good things of God,” she says, “are not external—they're inside of you when you know Him.”That truth allows us to face uncertainty with confidence, surrender our financial fears, and discover a hope that holds—no matter the storm.Learn MoreTo explore Katherine's ministry or support her work, visit HopeHeals.com.If you're near Atlanta, stop by Mend coffee shop in Buckhead—a place of belonging, beauty, and community. Katherine will also be speaking at the upcoming Kingdom Advisors Conference, where thousands of financial professionals gather to grow in biblical wisdom and stewardship. Learn more at RedeemingMoney.com.On Today's Program, Rob Answers Listener Questions:I invested based on the advice of a family friend who said it was guaranteed, but I lost $15,000. I'm single, I don't have much, and I was expecting this investment to return about $25,000. Now I'm just praying I'll have enough for rent next month. I'm calling to ask how I can recover from something like this.I have some real estate properties I want to leave to my children, and I've heard that putting them in a trust can help avoid capital gains. Do I need a trust for that? And should I also have a will?Resources Mentioned:Faithful Steward: FaithFi's Quarterly Magazine (Become a FaithFi Partner)Hope Heals | Hope Heals Camp | Mend Coffee & GoodsHope Heals: 
A True Story of Overwhelming Loss and an Overcoming Love by Katherine and Jay WolfTreasures in the Dark: 90 Reflections for Finding Bright Hope Hidden in the Hurting by Katherine Wolf with Alex WolfWisdom Over Wealth: 12 Lessons from Ecclesiastes on MoneyLook At The Sparrows: A 21-Day Devotional on Financial Fear and AnxietyRich Toward God: A Study on the Parable of the Rich FoolFind a Certified Kingdom Advisor (CKA)FaithFi App Remember, you can call in to ask your questions every workday at (800) 525-7000. Faith & Finance is also available on Moody Radio Network and American Family Radio. You can also visit FaithFi.com to connect with our online community and partner with us as we help more people live as faithful stewards of God's resources. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Trumpets of Tirzah
Breaking through Limitations - Learn to Reflect Heaven's Light!

Trumpets of Tirzah

Play Episode Listen Later Dec 8, 2025 15:06


Breaking through Limitations - Learn to Reflect Heaven's Light!What if your breakthrough was simpler than you think? When you understand and learn the directions in scripture - we can see that it is pretty simple.As we continue our study on Light - Pastor Carina takes us into scripture to discover how we can be a reflection of heaven's light here upon the earth.Pastor Carina is a Christian life coach, Keynote Speaker, and Mentor who God has uniquely gifted to activate others in the body of Christ. She carries an anointing to stir dormant callings, awaken spiritual gifts, and ignite Kingdom assignments,  empowering believers to step boldly into their God-given identity, walk in divine purpose, and bear lasting fruit for His glory. She's the Founder of Trumpets of Tirzah, an international apostolic center for women that facilitates purpose discovery, Kingdom lifestyle practices, and biblical leadership disciplines so that women can live, and lead, a "new creation" life that reflects Jesus. Her personal coaching, group mentoring, and Tirzah University courses provide keys of radical transformation that launch women into spheres of influence around the world.Tirzah University is the only educational institution in the world that focuses on the Apostolic role of women in the body of Christ while educating, equipping and empowering women to walk confidently in their God-given role. Come study with us: www.TirzahUniversity.com Your support plants seeds and grows the Kingdom of God! We are a 501c3 - www.trumpetsoftirzah.com/donateLuxury anointing oils and anointing lotions: https://www.trumpetsoftirzah.com/category/anointingPlease consider our shop for your gift-giving needs. Each purchase helps us continue to spread the gospel all around the world: https://www.trumpetsoftirzah.com/category/all-productsAnd take a look at how we are sharing the gospel through film:https://www.trumpetsoftirzah.com/mastersmedia*********************************************************** Join us for digital discipleship every Wednesday evening via our simultaneous livestream on YouTube and Rumble. YouTube: https://www.youtube.com/channel/UCV-ixRBTJm7sMvBXISpgAlwRumble: https://rumble.com/c/c-5936184Do you want your Christian product advertised on our podcast? https://www.fiverr.com/s/NNLl8pN Get your Amplified Bible: https://www.christianbook.com/Christian/Books/product?event=AFF&p=1223731&item_no=0446538We host in-person and virtual events. Check out our website events page to join in the fun. We are a community of women leaders with creative hearts desiring to follow the examples of Jesus above all else. www.TrumpetsOfTirzah.com/events Let's connect and journey through life together! Check out our Awaken Art events - they are creative virtual retreats that we host every month and create with the Holy Spirit. www.trumpetsoftirzah.art Engage daily with us! Instagram https://www.instagram.com/trumpetsoftirzah/ TikTok https://www.tiktok.com/@trumpetsoftirzahLinkedIn https://www.linkedin.com/company/trumpetsoftirzah iHeart Radio  ⁠https://www.iheart.com/podcast/269-trumpets-of-tirzah-120477377/⁠ Amazon Music. ⁠https://music.amazon.com/podcasts/c0203ed1-9b85-426a-85f5-5350e82ab730/trumpets-of-tirzah⁠ Apple Podcasts. ⁠https://podcasts.apple.com/us/podcast/trumpets-of-tirzah/id1551900025⁠ Spotify https://open.spotify.com/show/4DCT4KBVsmzfnqyobR4ZwF Apple Podcasts. https://podcasts.apple.com/us/podcast/trumpets-of-tirzah/id1551900025YouTube: https://www.youtube.com/c/TrumpetsofTirzahRumble: https://rumble.com/c/c-5936184Join Pastor Carina in this enriching `bible study` as she explores 1 John 1:7, encouraging a deeper `faith` and connection with `jesus`. This `christian motivation` will guide you in how to `trust god` daily, helping you find your purpose and experience personal growth.

Walk In Victory
Dr. Carrie Rose: Using AI to Build Profitable Online Courses That Students Finish

Walk In Victory

Play Episode Listen Later Dec 8, 2025 34:17 Transcription Available


Dr. Carrie Rose reveals how to use AI and ChatGPT to create online courses that students actually finish. Learn artificial intelligence strategies for course creators, educators, and entrepreneurs building profitable online education businesses.In this episode, NaRon and Dr. Carrie Rose break down the intersection of AI tools and online course creation—covering everything from avoiding common AI mistakes to improving course completion rates. Whether you're new to AI for beginners or scaling your online coaching business, you'll discover practical methodologies for leveraging generative AI without losing the human touch.WHAT YOU'LL LEARN:✅ How to use AI as a tool (not a crutch) in course design✅ Strategies to increase student engagement and completion rates✅ Building effective online course funnels in 2024✅ Differentiated learning approaches for online education✅ Real talk about AI limitations and hallucinations✅ Dr. Rose's personal journey overcoming challenges in entrepreneurshipTIMESTAMPS:00:00 Using AI for Relationship Advice00:17 Finalizing My Book and Course Alignment01:41 The Changing Landscape of Online Funnels02:30 Introduction to Walking Victory Podcast03:03 Impact of AI on Content Creation03:58 Missteps in Using AI for Methodology05:02 AI's Limitations and Hallucinations08:06 Personal Journey: Overcoming Challenges09:59 Building a Business Model in Online Coaching19:27 Effective Online Course Creation33:26 Conclusion and Call to ActionCONNECT WITH DR. CARRIE ROSE:Become a supporter of this podcast: https://www.spreaker.com/podcast/walk-in-victory--4078479/support.

TED Talks Daily
TED Talks Daily Book Club: Embrace your limitations | Oliver Burkeman

TED Talks Daily

Play Episode Listen Later Dec 7, 2025 36:03


How can you make your life meaningful with the finite amount of time you have? In this TED Talks Daily Book Club interview, host Elise Hu speaks with Oliver Burkeman about his book “Meditations for Mortals: Four Weeks to Embrace Your Limitations and Make Time for What Counts.” They explore Oliver's philosophy of “imperfectionism” and shows how choosing to let go can help you feel more in control. Hosted on Acast. See acast.com/privacy for more information.

Grace Family Church (Audio) - Weekly Service
Christmas, The Promise of Miracles - Week 1 - Something Experienced Beyond Your Limitations

Grace Family Church (Audio) - Weekly Service

Play Episode Listen Later Dec 7, 2025


Joni and Friends Radio
Glory in Your Limitations

Joni and Friends Radio

Play Episode Listen Later Dec 5, 2025 4:00


We would love to pray for you! Please send us your requests here. --------This Christmas, you can shine the light of Christ into places of darkness and pain with a purchase from the Joni and Friends Christmas catalog. You are sending hope and practical care to people with disabilities, all in the name of Jesus! Thank you for listening! Your support of Joni and Friends helps make this show possible. Joni and Friends envisions a world where every person with a disability finds hope, dignity, and their place in the body of Christ. Become part of the global movement today at www.joniandfriends.org. Find more encouragement on Instagram, TikTok, Facebook, and YouTube.

FT Politics
Deals, donations and damage limitation

FT Politics

Play Episode Listen Later Dec 5, 2025 39:34


Sir Keir Starmer started the week with not one but two speeches defending his party's Budget decisions in the wake of claims that chancellor Rachel Reeves had misled the public and fellow MPs about the state of the nation's finances. Was his sell convincing? The prime minister also brought up Brexit, but as panellist Robert Shrimsley points out, Starmer was characteristically unclear as to whether the Labour party was ultimately leaning into or out of the EU.Plus, host George Parker and the rest of the panel, Miranda Green and Jim Pickard, discuss the FT report that Nigel Farage told Reform UK donors he expects his party to do some sort of deal with the Tories in the run-up to the next general election — potentially helped by the single biggest donation any UK political party has had from a living donor. Follow George on Bluesky @georgewparker.bsky.social; Miranda @greenmirandahere.bsky.social; Jim @pickardje.bsky.social; Robert @robertshrimsley.bsky.social Want more? Free links: Nigel Farage tells donors he expects Reform UK will do an election deal with the ToriesHead of UK fiscal watchdog quits after Budget leak UK government orders review into rising diagnoses of mental health conditionsJanan Ganesh: The rise of unpopular populism UK envoy to Moscow enters race to be the next ambassador Political Fix will go live next week on Wednesday 10 December at 1.15pm. If you don't want to wait for it to drop in this feed on Friday, register here. Sign up to Stephen Bush's morning newsletter Inside Politics for straight-talking insight into the stories that matter. Get 30 days free at https://www.ft.com/InsidePoliticsOffer. For details about FLIC, the FT's Financial Literacy and Inclusion Campaign, read more about it here or click here and to donate, click here. Presented by George Parker, and produced by Lulu Smyth. The executive producer is Flo Phillips. Original music and mix by Breen Turner. The FT's acting co-head of audio is Manuela Saragosa. What did you think of this episode? Let us know at politicalfix@ft.com Hosted on Acast. See acast.com/privacy for more information.

Mind Matters
Exploring Consciousness in Human and Artificial Intelligence

Mind Matters

Play Episode Listen Later Dec 4, 2025 0:24


Today on Mind Matters News, hosts Robert J. Marks and Brian Krouse conclude their four-part conversation with Dr. Joseph Green on the limitations of modern neuroscience. Green is author of a chapter in the volume Minding the Brain called “On the Limitations of Cutting-Edge Neuroscience.” In today’s final segment, the discussion centers on comparing different models of consciousness, including panpsychism and Read More › Source

Joe Rose Show
Dolphins Defense Improves, Tua's Limitations Loom

Joe Rose Show

Play Episode Listen Later Dec 2, 2025 12:56


Joe and Hollywood highlight how many Dolphins players are stepping up as the defense continues its full transformation into a strength. But the conversation shifts to Tua Tagovailoa's inability to run, a growing frustration when compared to mobile stars like Josh Allen, Patrick Mahomes, Jaxson Dart, and Lamar Jackson. Despite those limitations, Joe still believes Tua will be Miami's starting quarterback next season — for better or worse.

Joe Rose Show
HR 2- Tua's Limitations, Kiffin's Controversy, Hollywood's Headlines

Joe Rose Show

Play Episode Listen Later Dec 2, 2025 32:59


Joe and Hollywood break down the Dolphins' surge, highlighting a transformed defense and standout performances across the roster. But Tua Tagovailoa's inability to run remains a major frustration, especially compared to mobile quarterbacks like Josh Allen, Patrick Mahomes, Jaxson Dart, and Lamar Jackson — yet Joe expects him to start next season. The conversation shifts to college football as Joe weighs in on Ole Miss' situation, Kiffin's move to LSU, and why he shouldn't coach the Rebels in the CFP. Hollywood's Headlines rounds out the hour, covering NFL RedZone's 16 commercials, Dillon Gabriel's girlfriend taking shots at the Browns, Kevin Patullo's house getting egged, Guy Fieri's serious injury, and high-dollar sports card auctions including Batman, Jordan, and Kobe collectibles.

Love Is Stronger Than Fear
The World Is the Wrong Shape for Women with Leah Libresco Sargeant

Love Is Stronger Than Fear

Play Episode Listen Later Dec 2, 2025 49:28 Transcription Available


S9 E5 — There is a lot of conversation right now about the role of women and men in society. Whether we're talking about the Jeffrey Epstein scandal or the viral essay "The Great Feminization" and all the commentary it sparked, it's clear we're in a cultural moment where we don't quite know how to talk about men and women. Should we see men and women as interchangeable? What does equality look like when our bodies are not the same? Can we admit our neediness and maintain our dignity as women or as men? These are some of the questions I'm asking Leah Libresco Sargeant as we talk about her new book, The Dignity of Dependence.00:00 The World is the Wrong Shape for Women6:14 The Lie of Autonomy and How It Harms Everyone21:09 Building a Just Society: Dismantling False Anthropology22:52 Understanding Disability and Unemployment25:43 Societal Examples of Dependent Communities30:15 The Dignity of Dependence32:51 Legacy of Care in Society38:20 The Costs of Devaluing Vulnerability41:14 Practices for Embracing DependenceMENTIONED IN THIS EPISODE:The Dignity of Dependence: A Feminist Manifesto by Leah Libresco SargeantSara Hendren's What Can a Body DoAmy Julia's interview with Sara Hendren: Who Belongs? Disability and the Built World with Sara Hendren_WATCH this conversation on YouTube: Amy Julia Becker on YouTubeSUBSCRIBE to Amy Julia's Substack: amyjuliabecker.substack.comJOIN the conversation on Instagram: @amyjuliabeckerLISTEN to more episodes: amyjuliabecker.com/shows/_ABOUT OUR GUEST:Leah Libresco Sargeant is the author of several books, including The Dignity of Dependence. She runs the substack Other Feminisms, which focuses on how to advocate for women as women in a world that makes an idol of autonomy. She lives in Maryland and works in family policy in D.C.Other Feminisms: https://www.otherfeminisms.com/Twitter: https://twitter.com/leahlibresco__We want to hear your thoughts. Send us a text!Connect with me: Instagram Facebook YouTube Website Thanks for listening!

Not Another Fitness Podcast: For Fitness Geeks Only
Episode 356: How Keto Affects Performance with Dr. Andrew Koutnik

Not Another Fitness Podcast: For Fitness Geeks Only

Play Episode Listen Later Dec 2, 2025 105:58


On this episode of the Flex Diet Podcast, I sit down with my good buddy and lab-coat-wearing performance wizard, Dr. Andrew Koutnik. We talk about how to boost muscle performance, improve body composition, and feel like an athletic human without dumpster-firing your health.We dig into cold water immersion (and when it can kick gains in the shins), blood glucose regulation, ketogenic diets, carbs (yes, they're still awesome), and how to build metabolic flexibility that actually translates to better outcomes in the gym and life.Andrew shares some killer insights from his research at Florida State University, especially around keto diets and athletic performance. If you're curious about whether low-carb can help or hurt your performance, this is your jam.If you want practical tools for a bigger physiological engine, tune in!Sponsors:Tecton Ketones: https://tectonketones.com/LMNT:  http://drinklmnt.com/mikenelson (automatically applied at Episode Chapters:05:28 Conferences and Networking08:34 The Importance of Practical Application in Science21:43 Cold Water Immersion and Stress Responses32:53 Mindfulness and Meditation39:29 Blood Glucose and Exercise Performance52:00 Limitations of Association Studies in Sports Performance52:47 Impact of Blood Glucose on Performance57:04 Historical Perspective on Ketogenic Diets01:00:52 Study on Ketogenic Diets and Ironman Competitors01:15:53 Health Implications of High Carbohydrate Diets01:18:48 Concluding Thoughts on Nutrition and Performance Episodes You Might Enjoy:Episode 254: Exploring the Frontiers of Ketone Science and Brain Health with Mike Chesne from Tecton LifeYouTube: https://youtu.be/uTsM_ETF8Us Episode 253: Enduring the Antarctic Chill and Unveiling the Power of Ketones with Akshay Nanavati and Tecton LifeYouTube: https://youtu.be/ockRFjBiOQcConnect with Dr Koutnik:Website: https://andrewkoutnik.com/Instagram: https://www.instagram.com/andrewkoutnikphd/Get In Touch:Instagram: https://www.instagram.com/drmiketnelson/YouTube: https://www.youtube.com/channel/UCn1aTbQqHglfNrENPm0GTpgEmail: https://miketnelson.com/contact-us/

Psound Bytes
Ep. #268 "Beyond the Surface: Rethinking Psoriasis Severity and Elevating the Patient Voice"

Psound Bytes

Play Episode Listen Later Dec 2, 2025 17:52


Description: Psoriatic disease affects far more than just the skin. Hear leading dermatologist Dr. April Armstrong and Dr. Benoît Guérrette discuss this and more with Jensen, a patient advocate. Psoriatic disease affects not only the skin but it can impact confidence, emotional and social well-being, and daily life. In this episode, join moderator Dr. Guy Eakin, Chief Scientific and Medical Officer at NPF, as we explore the disconnect between clinical classifications of psoriasis and what patients experience in real-life with leading dermatologist Dr. April Armstrong, Dr. Benoît Guérrette, Vice President of Dermatology & Rheumatology at Takeda, and Jensen, a NPF patient advocate and former Lead Youth Ambassador. Listen as we address the need for a more nuanced approach to classifying disease severity that accounts for the holistic needs of psoriatic disease, as well as share insights into how advocacy and awareness can drive change in treatment access and care standards.  The intent of this episode is to identify how clinical severity classifications of psoriasis are evolving to meet the needs of those who live with the disease and how that change impacts overall management. This episode is sponsored by Takeda. Timestamps: (0:00) Intro to Psoriasis Uncovered and guest welcome to dermatologist Dr. April Armstrong, Vice President of Takeda, Dr. Benoît Guérette, and patient advocate Jensen, who discuss the unmet needs of people with moderate psoriasis and how as a community we can better serve those living with the disease. 2:22 How health care providers and the biopharmaceutical industry are coming together to address systemic eligibility and the unmet needs of people living with psoriasis. 4:25 Quality of life should be included when assessing clinical severity in psoriasis and identification of appropriate treatment choices. 6:52 The impact of misdiagnosis, inappropriate treatment, and effect on high impact sites can be life- altering. 8:30 How appropriate treatment and knowledge can make all the difference when diagnosed with plaque psoriasis.  9:40 Views on the psoriasis disease classification system and how it's evolving to include real life impact from physical and emotional needs, to more personalized care for those living with psoriasis, even when small body surface areas are involved. Severity isn't defined by skin coverage alone. 12:38 What's needed to prioritize the care and outcomes of people living with psoriasis. 14:18  The future of management and care for psoriatic disease. 15:53  "My skin tells a story." Wisdom from what I wish I had known previously. 16:52  Moving closer to care that truly reflects the lives and needs of those who live with psoriasis. Key Takeaways: ·       Severity of psoriasis isn't defined by skin coverage or body surface area (BSA) alone. The impact on quality of life should also be considered in the assessment, selection of treatment, and management of the disease.  ·       The psoriasis disease classification system is evolving to be more of a patient centered approach.  Many clinicians are now using the International Psoriasis Council (IPC) or 2 bucket approach to identify whether someone should receive a topical or systemic treatment based on location and response to treatment, as well as impact on quality of life.  ·       With continued research and  development, the next 5 to 10 years could see a shift in effective treatment options while also treating sooner to initiate better outcomes for people living with psoriasis and psoriatic arthritis. Guest Bios:   April Armstrong, M.D., M.P.H. is an internationally renowned dermatologist and clinical researcher who is a Professor and Chief of Dermatology at the University of California Los Angeles (UCLA) where she specializes in inflammatory skin diseases such as psoriasis, atopic dermatitis, and hidradenitis suppurativa (HS). Dr. Armstrong is also the Co-Director for Network Resources at the UCLA Clinical and Translational Research Institute. She has conducted over 150 clinical trials and published over 350 high impact articles in scientific journals. Dr. Armstrong holds multiple leadership positions including the immediate Past Chair of the National Psoriasis Foundation Medical Board, Co-President of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA), councilor for the International Psoriasis Council, and board member for the International Dermatology Outcome Measures and the American Academy of Dermatology.  Benoît Guérette, Ph.D. is an accomplished leader in medical affairs with extensive experience across academia and the pharmaceutical industry. Since March 2025, Dr. Guérette has served as Vice President of Dermatology and Rheumatology US Medical Affairs at Takeda Pharmaceutical. Prior to joining Takeda, he held several strategic and leadership roles at various pharmaceutical companies, including overseeing clinical development, global and U.S. medical affairs, global access & pricing, translational sciences and more. Before transitioning to the industry, Dr. Guérette was an Associate Professor of Immunology at Laval University, leading research in cancer immunology. He holds a Ph.D. in Medicine, Microbiology, and Immunology from Laval University and completed postdoctoral studies in Inflammation and Immunology at  Harvard Medical School.  Jensen is a volunteer and former Lead Youth Ambassador for the National Psoriasis Foundation. Jensen developed psoriasis at age 7 but wasn't formally diagnosed until age 14 being misdiagnosed along the way, trying different management approaches that were ineffective. She was a competitive swimmer from elementary through high school and in the last 2 years of high school played lacrosse. Upon finishing high school she attended college becoming a registered nurse in an intensive care unit. Jensen wants "youth living with psoriatic disease to feel a  community that is behind them and with them every step of the way. I really want to be able to make a difference in a way that would've helped me as a child when I was diagnosed." Resources: Ø  "Reassessing Psoriasis Severity" Advance Online, National Psoriasis Foundation. H. Onorati. January 16, 2024,  https://www.psoriasis.org/advance/psoriasis-severity-high-impact-sites/   Ø  "Psoriasis Involving Special Areas is Associated with Worse Quality of Life, Depression, and Limitations in the Ability to Participate in Social Roles and Activities". Blauvelt, A., Strober, B., Gondo, G., Journal of Psoriasis and Psoriatic Arthritis Volume 8, Issue 3.  https://journals.sagepub.com/doi/full/10.1177/24755303231160683

Cloud Accounting Podcast
What Americans Are Most Afraid of Discussing at Thanksgiving

Cloud Accounting Podcast

Play Episode Listen Later Nov 28, 2025 52:21


Do money talks make your family squirm more than politics? In this Thanksgiving mailbag, Blake and David dig into a Bankrate survey on taboo money chats, the grim 2026 grad job market, and the maze of CPA experience sign-offs after NASBA's program vanished. You'll hear practical career advice (big firm vs. small, starting bookkeeping), what AI can and can't do for accountants today, plus news on audit partners' outlook and tariff shifts hitting grocery bills.SponsorsOnPay - http://accountingpodcast.promo/onpay Cloud Accountant Staffing - http://accountingpodcast.promo/casChapters(01:14) - Listener Mailbag: Top Messages of the Year (02:05) - Thanksgiving Dinner Conversations: Money vs. Politics (06:11) - Listener Questions: CPA Licensing Challenges (12:07) - NASBA Data Issues and CPA Exam Pass Rates (13:24) - Economic Optimism Among Audit Partners (17:22) - Political News: Tariff Rollbacks (19:03) - Career Advice for Accounting Students (26:47) - AI's Impact on Accounting Careers (27:34) - AI's Current Capabilities and Limitations (31:10) - Future of AI in Accounting (34:49) - Challenges in Accounting Education (40:51) - Listener Mail and Feedback (46:23) - Accounting News and Stories  Show NotesCompanies Predict 2026 Will Be the Worst College Grad Job Market in Five Years https://www.wsj.com/lifestyle/careers/2026-graduates-job-market-7928bcd7 Survey: Americans would rather discuss politics or religion than what's in their bank accounts https://www.bankrate.com/banking/financial-taboos-survey/ Audit partners feel more optimistic about economy https://www.accountingtoday.com/news/audit-partners-feel-more-optimistic-about-economy Trump lowers tariffs on coffee, beef and fruits, as Americans' concerns about affordability grow https://www.cnn.com/2025/11/14/economy/lower-tariffs-coffee-beef-bananas-produce Georgia Accountant Arrested After Allegedly Tearing Down Trump Sign, Shooting at North Carolina Man's Househttps://www.cpapracticeadvisor.com/2025/10/24/georgia-accountant-arrested-after-allegedly-tearing-down-trump-sign-shooting-at-north-carolina-mans-house/171649/ Measuring AI Ability to Complete Long Tasks https://metr.org/blog/2025-03-19-measuring-ai-ability-to-complete-long-tasks/Need CPE?Get CPE for listening to podcasts with Earmark: https://earmarkcpe.comSubscribe to the Earmark Podcast: https://podcast.earmarkcpe.comGet in TouchThanks for listening and the great reviews! We appreciate you! Follow and tweet @BlakeTOliver and @DavidLeary. Find us on Facebook and Instagram. If you like what you hear, please do us a favor and write a review on Apple Podcasts or Podchaser. Call us and leave a voicemail; maybe we'll play it on the show. DIAL (202) 695-1040.SponsorshipsAre you interested in sponsoring The Accounting Podcast? For details, read the prospectus.Need Accounting Conference Info? Check out our new website - accountingconferences.comLimited edition shirts, stickers, and other necessitiesTeePublic Store: http://cloudacctpod.link/merchSubscribeApple Podcasts: http://cloudacctpod.link/ApplePodcastsYouTube: https://www.youtube.com/@TheAccountingPodcastSpotify: http://cloudacctpod.link/SpotifyPodchaser: http://cloudacctpod.link/podchaserStitcher: http://cloudacctpod.link/StitcherOvercast: http://cloudacctpod.link/OvercastClassifiedsCollective by DBA - https://collective.cpa/ Want to get the word out about your newsletter, webinar, party, Facebook group, podcast, e-book, job posting, or that fancy Excel macro you just created? Let the listeners of The Accounting Podcast know by running a classified ad. Go here to create your classified ad: https://cloudacctpod.link/RunClassifiedAdTranscriptsThe full transcript for this episode is available by clicking on the Transcript tab at the top of this page

The John Batchelor Show
S8 Ep122: The Unacceptable Price of Peace: Ukraine's Sticking Points — John Hardie — John Hardie details the Russian-drafted 28-point peace plan, which demanded Ukraine's withdrawal from Donbass, prohibition of NATO accession, and limitations on mil

The John Batchelor Show

Play Episode Listen Later Nov 25, 2025 12:30


The Unacceptable Price of Peace: Ukraine's Sticking Points — John Hardie — John Hardie details the Russian-drafted 28-point peace plan, which demanded Ukraine's withdrawal from Donbass, prohibition of NATO accession, and limitations on military force size. Ukraine, approaching negotiations strategically, refuses to surrender fortified Donbass territory essential for defense against future Russian aggression. Russia's maximalist demands render an acceptable settlement nearly impossible, though Ukrainians would accept a military freeze in place coupled with robust Western security guarantees. 1900 KYI1V

Simple Passive Cashflow
Taxes Before Year-End: Using Oil & Gas Investments to Lower Ordinary Income

Simple Passive Cashflow

Play Episode Listen Later Nov 25, 2025 63:34


In this episode, Lane and guest tax expert Jack Hollander dive into strategies for offsetting ordinary income through oil and gas investments. They discuss the unique tax benefits, including intangible drilling costs and depletion allowances, and how these can provide significant deductions for high-income earners. The conversation addresses common mistakes with passive losses and real estate professional status, provides insights into how to properly utilize oil and gas investments, and answers questions on minimizing tax liabilities and optimizing portfolio strategies.00:00 Introduction to Tax Deductions in Oil and Gas Investments00:39 Understanding Passive and Ordinary Income01:11 Limitations of Passive Losses02:09 Real Estate Professional Status and Short-Term Rentals02:48 Introduction to Oil and Gas Investments03:02 Misconceptions About Bonus Depreciation06:08 Importance of Consulting Professional Advisors07:42 Basics of Tax Law and Income Buckets12:07 Financial Planning and Investment Considerations13:24 How Oil and Gas Investments Fit into a Portfolio15:23 Tax Benefits of Oil and Gas Investments23:53 Intangible Drilling Costs (IDCs) Explained35:16 Understanding Passive Losses and Tax Benefits35:53 Investment Strategies for Self-Employed Individuals36:33 Navigating Tax Forms and Returns37:27 Managing Investment Expectations38:37 Cash Flow and Tax Savings39:49 Evaluating Oil and Gas Investments41:15 Portfolio Diversification and Tax Planning43:15 Risk Management in Oil and Gas Investments53:09 Using IRAs and Roth Conversions01:03:01 Final Thoughts and Upcoming Events Hosted on Acast. See acast.com/privacy for more information.

The Rich Roll Podcast
The Productivity Myth: Oliver Burkeman On Our Broken Relationship With Time, Embracing Our Limitations & Why More Isn't Always Better

The Rich Roll Podcast

Play Episode Listen Later Nov 24, 2025 119:15


Oliver Burkeman is a bestselling author, journalist, and the mind behind “Four Thousand Weeks: Time Management for Mortals” and “Meditations for Mortals.” We explore our broken relationship with time and Oliver's philosophy of imperfectionism, which dismantles the delusion that productivity is a moral imperative. Oliver explains why we're all chasing an infinite backlog, how perfectionism keeps us from doing the work, the path from overwhelm to agency, why acceptance isn't resignation, and the mystical energy of completion. Along the way, Oliver diagnoses my biggest malfunction and exposes an uncomfortable truth about my people-pleasing tendencies. Oliver's work is vital. And this conversation might just change your life. Enjoy!  Show notes + MORE Watch on YouTube Newsletter Sign-Up  Today's Sponsors: Momentous: High-caliber human performance products for sleep, focus, longevity, and more. For listeners of the show, Momentous is offering up to 35% off your first order