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On this episode of "49ers Talk," co-hosts Matt Maiocco and Jennifer Lee Chan reflect on the blockbuster trade that brought Christian McCaffrey to San Francisco ahead of Monday night's matchup against his former team. Additionally, Matt and Jennifer discuss how a healthy 49ers offense will improve their run game. Matt then sits down with defensive back Deommodore Lenoir to discuss his growth as a leader and team captain of the 49ers' defense.--(1:53) Matt, JLC reflect on 49ers' trade that brought Christian McCaffrey to San Francisco(6:12) Matt discusses how CMC has blossomed into face of the 49ers' offense and playing at an all-time level(12:56) Matt, JLC discuss how a healthy 49ers offense will improve CMC's running game(17:08) Matt, JLC debate if matchup vs. Panthers is a must-win game(25:00) Deommodore Lenoir discusses what it means to him to be a captain on the 49ers, and finding his voice, role as a leader(29:05) Lenoir talks how Richard Sherman took notice of his potential as a young player(37:55) Matt, JLC discuss if Lenoir get enough attention for his playmaking(42:20) Matt wants to see rookie LB Nick Martin on the field as a pass rusher Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Dirty Work Hour 1: 49ers/Panthers preview, Matchups vs Rico Dowdle, T-Mac and Bryce Young, CMC vs his old teamSee omnystudio.com/listener for privacy information.
What if you could analyze every metabolite, glycan variant, and unknown impurity in your bioprocess sample—not just the targets you're looking for, but everything that's actually there? Cryogenic infrared ion spectroscopy combined (CIRIS) with AI-powered analysis transforms untargeted screening from aspiration to reality.This episode moves from fundamental principles to practical applications. While Part 1 established how CIRIS overcomes mass spectrometry's structural limitations, Part 2 reveals what becomes possible when you can definitively identify complex mixtures: better mAb characterization, earlier disease detection, and process decisions based on complete data rather than educated guesses.Professor Tom Rizzo returns to discuss Isospec Analytics' path from laboratory innovation to commercial service platform. His transition from academic leadership at EPFL to biotech entrepreneurship offers insights for any scientist considering whether breakthrough research deserves a startup—and what that journey actually requires.For bioprocess scientists drowning in unidentified peaks, struggling with glycan heterogeneity, or making critical manufacturing decisions with incomplete analytical data, this conversation demonstrates how next-generation analytics powered by quantum chemistry and machine learning can illuminate what's been hidden in your samples all along.Episode Highlights:Why targeted metabolomics creates a "streetlight effect"—and how untargeted CIRIS analysis reveals the complete molecular landscape (00:00)Isomer-specific glycan characterization for mAbs: distinguishing structural variants that impact efficacy and immunogenicity (03:17)Advanced disease detection and biomarker discovery: identifying diagnostic signatures in complex biological matrices (05:21)AI meets quantum chemistry: automated spectral library building and machine learning algorithms that accelerate molecule identification from hours to seconds (06:05)From data generation to decision-making: how comprehensive analytics and AI transform bioprocess development workflows (09:23)Isospec's commercial roadmap: service platform for comprehensive sample analysis and projected timeline for benchtop instrumentation (10:09)Academic to entrepreneur: Tom Rizzo's perspective on leaving tenure for a startup, with practical advice for scientists evaluating the leap (12:05)Personal motivation behind early diagnostics: cancer and leukemia experiences that drive Isospec's clinical applications (14:11)Technical deep dive: messenger tagging methodology and achieving single-ion infrared detection sensitivity (15:41)The transformative capability: adding a structural dimension to mass spec data that eliminates ambiguity in complex mixture analysis (17:55)Mass spectrometry tells you what masses are present. Cryogenic infrared ion spectroscopy tells you what molecules they actually are. When coupled with AI-powered analysis, this combination enables truly comprehensive characterization—from process impurity identification to critical quality attribute assessment to early disease biomarker discovery.If you're making bioprocess decisions with incomplete analytical information, managing glycan complexity in biologics development, or exploring how emerging analytical technologies could solve your toughest characterization challenges, this episode provides both the technical foundation and the commercial pathway forward.
Welcome to the Paint The Medical Picture Podcast, created and hosted by Sonal Patel, CPMA, CPC, CMC, ICD-10-CM.Thanks to all of you for making this a Top 15 Medical Billing & Coding Podcast for 5 Years on Feedspot. Sonal's 16th Season starts up and Episode 12 features a Newsworthy update on RAC audits for 2025.Sonal's Trusty Tip and compliance recommendations focus on specific RAC audits for 2025.Spark inspires us all to reflect on resilience based on the inspirational words of Isabel Allende.Paint The Medical Picture Podcast now on:Spotify: https://open.spotify.com/show/6hcJAHHrqNLo9UmKtqRP3XApple Podcasts: https://podcasts.apple.com/us/podcast/paint-the-medical-picture-podcast/id1530442177Amazon Music: https://music.amazon.com/podcasts/bc6146d7-3d30-4b73-ae7f-d77d6046fe6a/paint-the-medical-picture-podcastFind Paint The Medical Picture Podcast on YouTube: https://www.youtube.com/channel/UCzNUxmYdIU_U8I5hP91Kk7AFind Sonal on LinkedIn: https://www.linkedin.com/in/sonapate/And checkout the website: https://paintthemedicalpicturepodcast.com/If you'd like to be a sponsor of the Paint The Medical Picture Podcast series, please contact Sonal directly for pricing: PaintTheMedicalPicturePodcast@gmail.com
Children's mental health isn't just a family issue—it's a workplace issue. When kids struggle, parents and caregivers face missed work and mounting stress, creating ripple effects across their lives. This week we explore the link between children's mental health and workplace performance, and the roles Central Ohio employers, healthcare leaders, and advocates are playing in breaking the cycle of stress for families. Featuring: Anna Ankenbauer, Senior Director, Global Giving, Engagement, Learning & Development, Abercrombie & Fitch Co. Nina Day, Community Mental Health Advocate. Dr. Ariana Hoet, Executive Director, The Kids Mental Health Foundation. The host is Cierra Johnson, Anchor & Reporter, NBC4. This forum was sponsored by Cardinal Health. The presenting sponsor of the CMC livestream was The Center for Human Kindness at the Columbus Foundation. CMC's livestream partner was The Columbus Dispatch. This forum was also supported by Downtown Columbus, Inc. and The National Veterans Memorial and Museum. If you're ready to keep exploring this week's forum topic, our partners at The Columbus Metropolitan Library recommend reading Finding Time: The Economics of Work-Life Conflict, by Heather Boushey. This forum was recorded before a live audience at The National Veterans Memorial and Museum in Columbus, Ohio on November 19, 2025.
Damon Bruce Plus: Warriors, 49ers, Giants, A’s Bay Area Sports Talk
1:55: The opening statement of Christian McCaffrey's MVP case:11:24: The 49ers win 75 PERCENT of the time with McCaffrey in the lineup12:26: Rant: How does Kyle Shanahan still not understand that the 49ers are “totally f—ked” without CMC? — Get him off the field in blowouts18:10: McCaffrey is even more valuable than Kyle21:13: Somehow, Shedeur Sanders' nightmare debut got even worse after the game37:21: Draymond Green's big mistake after the Angel Reese chant:47:51: Today in history: Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
What if you could identify every structural variant in your biologics—without ambiguity, without massive sample requirements, and without the guesswork that plagues traditional mass spectrometry? Cryogenic infrared ion spectroscopy (CIRIS) makes it possible, transforming molecular characterization from frustrating puzzle to precise science.Today's guest, Professor Tom Rizzo, bridges the gap between academic innovation and industrial application. As former Dean of the School of Basic Sciences at EPFL in Lausanne and now Chief Scientific Officer at Isospec Analytics, Tom has spent over two decades developing analytical techniques that solve problems conventional methods can't touch.His journey from a childhood fascination sparked by chemistry demonstrations at the 1964 New York World's Fair to pioneering a breakthrough technology reveals both the persistence required for true innovation and the pathway from laboratory curiosity to commercial reality. For bioprocess scientists struggling with glycan characterization, isomer identification, or any structural puzzle where mass spec alone falls short, this conversation offers both validation and solutions.Episode Highlights:The fundamental limitations of current biomolecular analysis methods and why innovation is critical (02:51)From World's Fair chemistry demos to laser spectroscopy: Tom Rizzo's path to analytical innovation (03:31)The two-decade quest to combine mass spectrometry sensitivity with laser spectroscopy precision—and the machine that finally made it work (04:26)Why Tom transitioned from academic leadership to Isospec Analytics: bringing lab techniques to production environments (09:17)CIRIS fundamentals: how cooling ions to 10 Kelvin unlocks molecular fingerprints that room-temperature methods miss (11:14)CIRIS advantages for biologics: single-ion sensitivity, isomer discrimination, and unique molecular "fingerprints" for definitive identification (14:25)Integrating CIRIS into existing bioprocess workflows: LC-MS compatibility and the path to commercial instrumentation (17:29)Hard-won lessons from translating academic breakthroughs into industrial tools (17:43)When mass spectrometry hits its limits—distinguishing isomers, characterizing glycans, identifying unknowns in complex mixtures—cryogenic infrared ion spectroscopy provides the structural resolution you need. This isn't incremental improvement; it's a fundamental expansion of what's analytically possible.If you're facing molecular identification challenges that conventional methods can't solve, or if you're curious how next-generation analytical techniques will transform bioprocess development, this episode delivers actionable insights from a scientist who's lived both the innovation and implementation journey.Connect with Tom Rizzo:LinkedIn: www.linkedin.com/in/thomas-rizzo-4a0a6314/Contact email: tom@isospec.chIsospec Analytics website: www.isospecanalytics.comNext step:Book a 20-minute call to help you get started on any questions you may have about bioprocessing analytics: https://bruehlmann-consulting.com/call
Brock Purdy's return sparked the 49ers' offense, it also brought a much needed divisional win in a blowout against the Cardinals. Purdy threw for three touchdowns on Sunday, two of which went to a favorite target in tight end George Kittle and the other went to offensive fulcrum Christian McCaffrey, who leads the NFL in scrimmage yards this season through Week 11. Skyy Moore set the tone, returning the opening kickoff 98 yards to the 1-yard line, setting up a McCaffrey 1-yard touchdown run. San Francisco maintained control throughout the game, one in which Arizona did itself no favors accumulating a franchise-record 17 penalties. San Francisco did not escape Arizona unscathed though, as kicker Eddy Piñeiro suffered a hamstring injury in the third quarter that could force the team to bring in a new kicker. On this episode of '49ers Talk,' co-hosts Matt Maiocco and Jennifer Lee Chan break down San Francisco's outstanding performance against the Cardinals Sunday at State Farm Stadium. Matt and Jennifer discuss the impact of Purdy's return on the 49ers' offense during a crucial stretch, Kittle and CMC's dominance, and how injuries to both Piñeiro and linebacker Tatum Bethune might affect the team ahead of Monday's showdown with the Carolina Panthers.--(0:00) 49ers did what they had to do to get win vs. Cardinals(3:00) Will the 49ers have to add a kicker because of Eddy Piñeiro's injury?(4:00) Brock Purdy's return dispels any QB controversy from media(12:00) Can CMC achieve 1,000-1,000 season?(14:00) This is the healthiest the 49ers have been on offense all season(17:30) The 49ers' defense forced three takeaways(25:00) What type of team are the 49ers? Can they bring this type of performance on MNF?(28:00) Robert Saleh will really have to earn his money down the stretch this season(30:00) Looking ahead, the 49ers need beat NFC playoff contenders Carolina, Chicago Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
The San Francisco 49ers dominated the Cardinals 41-22 in Week 11 behind a huge day from Brock Purdy, Christian McCaffrey, and George Kittle. Purdy returned to the lineup with 3 touchdowns, including two to Kittle and one to CMC, as Kyle Shanahan kept the offense aggressive all game long.Special teams set the tone early with Skyy Moore's 98-yard kickoff return, leading to a quick McCaffrey TD. CMC finished with 3 total touchdowns, 121 scrimmage yards, and his first 20+ yard run of the season. Kittle added 6 catches, 67 yards, and 2 scores in another dominant outing.The 49ers defense delivered 3 takeaways (INTs by Lenoir and Mustapha, a goal-line FF by Upton Stout) and made key stops despite coverage issues and a quiet pass rush. Arizona hurt themselves with 17 penalties for 130 yards, while San Francisco committed just one.Visit Sports Spyder for up to date 49ers content: https://sportspyder.com/nfl/san-francisco-49ers/newsFollow us on Twitter @49ers_AccessFollow us on Instagram @49ers.AccessSeatGeek: “49ERSACCESS” for $20 off your first purchase!#49ers #Cardinals #NFLWeek11 #SanFrancisco49ers #ArizonaCardinals
HOST: Mark Longo, The Options Insider CO-HOST: Mike Tosaw, St. Charles Wealth Management CO-HOST: Andrew Giovinazzi, The Option Pit In this episode, the panel discusses the current state of the options market. They also look at unusual options activity in CMC and QGEN. Uncle Mike Tosaw provides a Strategy Block focusing on the importance of responsible options trading and knowing when to exit a position. Market conditions, including significant whipsaw action in the S&P 500 and notable upcoming earnings reports from major retailers like Home Depot, Lowe's, and Target, are analyzed. The episode concludes with insights on what the hosts are watching in the market for the upcoming week.
Week 11 NFL DFS was a rollercoaster of chalk. Did Davis, Sammy, and Nate find a way to the top?
JMToWin from One Week Season walks us through the Week 11 DFS slate from a GPP perspective, shares his top plays at each position, and then builds a DraftKings lineup using some of his favorite building blocks. In the second half, Youdacao from Run The Sims join to discuss sneaky stacks for Week 11 tournaments and input volatility.
In this episode of Molecule to Market, your host Raman Sehgal discusses the pharmaceutical and biotechnology supply chain with Jean-François Brepson, Chief Executive Officer at PathoQuest. The conversation covers: Navigating 20 years of global leadership roles at Ipsen before moving from the corporate world into an investor-led entrepreneurial adventure The tough decision to refocus PathoQuest from diagnostics into a pure play CRO and pharma services business How a major strategic partnership transformed the company's trajectory and why Jean sees partnerships as a competitive weapon Riding the tailwind of the FDA's move away from animal testing and offering something game-changing in the CMC and GMP space The opportunities ahead for CROs and CDMOs in helping unlock the next wave of innovation Jean-François Brepson is a dedicated leader with deep experience in biotechnology and pharmaceuticals. Since becoming CEO of PathoQuest in 2015, he has built the company into a leading global CRO specializing in quality control of biological drugs using Next Generation Sequencing (NGS). Over his career, he has advanced innovative technologies and solutions that bridge scientific progress with real-world application. Prior to joining PathoQuest, Jean was Senior Vice President at Ipsen, where he led the global GI-Oncology and Endocrinology franchise. Molecule to Market is sponsored by Bora Pharma, Charles River, and Lead Candidate. Please subscribe, tell your industry colleagues, and help us celebrate the value of the global life science outsourcing space. We'd also appreciate a positive rating!
Carbon neutrality goals are everywhere in biopharma. But how do you actually measure and reduce your true environmental impact when data gaps and baseline differences make comparisons so tough?In this episode, David Brühlmann talks with Niklas Jungnelius, Cytiva's expert in process modeling and sustainability, who's spent years uncovering what really drives emissions and how small process tweaks can deliver big results.Niklas goes beyond the numbers, challenging assumptions and showing how sustainability becomes a strategic, data-driven advantage. From real-world cases at Cytiva, he explains why recycling plastics may not move the needle and why the real gains often lie in hotspots like cleanroom energy use and raw material choices.Here's why this episode will make you rethink your next facility upgrade:Understanding life cycle assessment and the key damage categories in environmental sustainability, including carbon emissions, water usage, and resource depletion. (00:00)The challenge of defining carbon emissions baselines and why it's harder, and often more expensive, to achieve deep reductions if your operations already use clean energy sources. (03:06)Why the focus on recycling single-use plastics may not be the most effective route for lowering emissions, and what truly drives carbon footprint in bioprocessing. (05:54)The impact of production scale, consumables, and obscure chemicals on the overall environmental impact and how these surprises can shift sustainability strategies. (06:20)Practical advice for scientists and engineers: How to start monitoring and modeling environmental impact in process development and manufacturing. (08:00)The importance of involving manufacturing perspectives early in process development, and choosing the right level of detail and ambition for process modeling. (08:18)There's no one-size-fits-all in manufacturing technology—whether fed-batch, continuous, or hybrid and decisions must fit each organization's needs, resources, and ambitions. (10:13)Industry trends that could transform the field, from intensified fed-batch production to future technologies like cell-free expression systems. (11:22)Where to connect with Niklas for further questions or collaboration. (14:03]Whether you're an early-stage startup, a strategic advisor, or on the front lines of bioprocess development, this episode invites you to rethink your sustainability strategy and modeling approach. Check out the below links to connect with Niklas Jungnelius and additional resources.Connect with Niklas Jungnelius:LinkedIn: www.linkedin.com/in/niklas-jungneliusCytiva website: www.cytivalifesciences.com/en/usNext step:Book a 20-minute call to help you get started on any questions you may have about bioprocessing analytics: https://bruehlmann-consulting.com/call
Welcome to the Paint The Medical Picture Podcast, created and hosted by Sonal Patel, CPMA, CPC, CMC, ICD-10-CM.Thanks to all of you for making this a Top 15 Medical Billing & Coding Podcast for 5 Years on Feedspot. Sonal's 16th Season starts up and Episode 11 features a Newsworthy update on the OIG Work Plan for October 2025.Sonal's Trusty Tip and compliance recommendations focus on another claims processing update from Medicare.Spark inspires us all to reflect on resilience based on the inspirational words of Ernest Hemingway.Paint The Medical Picture Podcast now on:Spotify: https://open.spotify.com/show/6hcJAHHrqNLo9UmKtqRP3XApple Podcasts: https://podcasts.apple.com/us/podcast/paint-the-medical-picture-podcast/id1530442177Amazon Music: https://music.amazon.com/podcasts/bc6146d7-3d30-4b73-ae7f-d77d6046fe6a/paint-the-medical-picture-podcastFind Paint The Medical Picture Podcast on YouTube: https://www.youtube.com/channel/UCzNUxmYdIU_U8I5hP91Kk7AFind Sonal on LinkedIn: https://www.linkedin.com/in/sonapate/And checkout the website: https://paintthemedicalpicturepodcast.com/If you'd like to be a sponsor of the Paint The Medical Picture Podcast series, please contact Sonal directly for pricing: PaintTheMedicalPicturePodcast@gmail.com
Small businesses are the backbone of Central Ohio's economy—creating jobs, fueling innovation, and shaping the future of our communities. Despite inflation, labor shortages, and tariffs, many small business owners report feeling optimistic about the future. This week we explore why. Featuring: Stuart Hoffman, Senior Economic Advisor, PNC Financial Services Group Tim Kehoe, Director, Economic and Community Development Institute's Veterans Business Outreach Center of Ohio Ariana Ulloa-Olavarrieta, Small Business Coordinator, City of Columbus Walter Eguez, Founder, Tortilla Street Food The host is Susan Post, Digital Editor, Columbus Business First. This forum was sponsored by PNC. The presenting sponsor of the CMC livestream was The Center for Human Kindness at the Columbus Foundation. CMC's livestream partner was The Columbus Dispatch. This forum was also supported by Downtown Columbus, Inc. and The National Veterans Memorial and Museum. If you're ready to keep exploring this week's forum topic, our friends at the Columbus Metropolitan Library recommend reading The New Builders: Face to Face with the True Future of Business by Seth Levine. This forum was recorded before a live audience at The National Veterans Memorial and Museum in Columbus, Ohio on November 12, 2025.
Your Manufacturing Decisions Are Costing You More Than You ThinkEvery bioreactor decision. Every scale-up choice. Every facility investment. They're all silently writing checks your process might not be able to cash.The difference between a profitable biologics program and one that bleeds capital? Process economic modeling, the analytical framework that reveals exactly where your money goes and why.In this episode of the Smart Biotech Scientist Podcast, David Brühlmann talks with Niklas Jungnelius, Process Modeling Leader at Cytiva, who has spent 25+ years decoding the economics of biologics manufacturing for biotech companies navigating billion-dollar decisions.Niklas reveals the hidden cost drivers most teams miss, the surprising economics behind fed-batch vs. continuous processing, and why your facility choice at intermediate scale could make or break your business case.Episode Highlights:What process economic modeling is and how it differs from mechanistic modeling (06:40)Main cost drivers in biologics and biosimilars manufacturing, and their direct and indirect impacts on patient pricing (09:21)The role of manufacturing scale and productivity in driving down costs, and how facility type (stainless steel vs single-use) affects labor, flexibility, and investment (11:51)Trade-offs between single-use and stainless steel facilities at intermediate production scales (15:07)Key differences in cost and efficiency between fed-batch and fully continuous manufacturing, including productivity limitations and capital/expenditure implications (16:20)The impact of resin lifetime and under-utilization on clinical manufacturing costs (19:51)Hidden or less quantifiable costs such as facility flexibility, excess capacity, safety margins, and the importance of realistic assumptions in economic modeling (20:20)This is a grounded discussion with practical takeaways for biotech scientists seeking clarity in the complex terrain of process economics. Part two of this conversation will focus on sustainability modeling and the latest technologies reshaping bioprocessing economics.Ready to see how process modeling could transform your approach and protect your bottom line? Listen to the episode and rethink your next investment.Connect with Niklas Jungnelius:LinkedIn: www.linkedin.com/in/niklas-jungneliusCytiva website: www.cytivalifesciences.com/en/usNext step:Book a 20-minute call to help you get started on any questions you may have about bioprocessing analytics: https://bruehlmann-consulting.com/call
Damon Bruce Plus: Warriors, 49ers, Giants, A’s Bay Area Sports Talk
0:15: That was awful from the jump — “Kyle is playing with fire”, get the starters out of there5:45: Unfortunately for the 49ers, the Rams and Seahawks are both very, very good7:40: As bad as this looks, the 49ers are about to go 4-012:22: Stick with Mac Jones (through the bye week) — he's given the 49ers no reason to take him off the field14:22: Why do 49ers keep getting hurt in PRACTICE?15:29: Rant: “I'm over Jauan Jennings”16:21: A deep dive on the draft failures of Shanahan and Lynch:24:36: Speaking of young guys who don't matter — look at the Warriors:26:18: RIP Lenny Wilkens and Paul Tagliabue29:56: The sports gambling “locomotive” is about to hit the industry: Hello, Guardians pitchers34:22: Today in history: Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
We just lowered the prices on all of our packages, and promo code 'GURU' gets you an extra 15% off of our already discounted 50% off price tag. https://www.fantasypoints.com/plans#/ Get ready for a wild ride! John Hansen and Brian Drake bring unmatched energy as they tear through every game from NFL Week 10 on the Fantasy Points Podcast. From Jonathan Taylor's monster performance and Tez Johnson's breakout to Trey McBride's domination, the duo leaves no fantasy storyline untouched. Expect bold takes, sharp betting advice, and unfiltered banter as they spotlight key trends from Lamar Jackson's continued tear, CMC's revenge game, and Detroit's rise. Packed with insider stats, waiver wire gems, and league-winning strategy, this is fantasy football analysis at full throttle. Tune in and get ready to CRUSH Week 11. Where to find us: http//twitter.com/Fantasy_Guru http://twitter.com/DrakeFantasy Podcast Transcription Here: https://podsqueeze.com/embedded/transcript/7WCRFizJRc3MAfGQZKazRw Join our Discord here: https://www.fantasypoints.com/media/discord#/ Subscribe to Fantasy Points for FREE - https://www.fantasypoints.com/plans#/ Listen to the podcast here: https://www.fantasypoints.com/media/podcasts #FantasyFootball #FantasyFootball2025 #NFLWeek6 #FantasyPointsPodcast #FantasyFootballAnalysis #NFLRecap #FantasyFootballAdvice #FantasyPoints #NFL2025 Learn more about your ad choices. Visit megaphone.fm/adchoices
Todd and Jerry talk about the big win in NY against the Giants, but at what cost...they lose Mykel Williams to a torn ACL.CMC continues to carry the team. Mac Jones looks good.BUT, why was there no help at the trade deadline? Major questions there.A spin around the whole NFL and Todd gives another reason he dislikes Halloween.
Cell and gene therapies are transforming modern medicine, but their path to market is fast and complex. They often jump from small trials to global launch at record speed, putting pressure on analytics, supply chains, and partnerships. Success depends on making smart choices about what to build in-house and what to entrust to expert partners.Daniel Galbraith knows these challenges intimately. With decades of hands-on experience and as Chief Scientific Officer at Solvias, Daniel has witnessed firsthand the seismic shifts in analytical development for advanced therapies. He's been on every side of the table: troubleshooting manufacturing snags, scaling up from a single batch to hundreds per month, and guiding companies as they choose between in-house development and relying on a CRO's muscle.In this episode:How evolving cell and gene therapy timelines are driving the need for true CRO-drug developer partnerships (00:00)The unique challenges of scaling CMC analytics from early trials to global commercialization (02:51)Key pitfalls to avoid when outsourcing to CROs—especially around communication, scheduling, and troubleshooting (06:26)Deciding whether to build capabilities in-house or outsource to a CRO, and how to find the right balance for your team (08:41)The critical importance of strong project management for juggling relationships between developer, CRO, and CDMO (09:51)Daniel's perspective on the future of combination therapies and what the analytical landscape will demand of CROs (13:33)Practical advice for building transparent, open CRO partnerships that support your goals (15:21)Facing scale-up challenges or a first CGT launch? This conversation shares practical strategies to advance therapies efficiently.Tune in for actionable insights on CMC, outsourcing, and analytical development.Connect with Daniel Galbraith:LinkedIn: www.linkedin.com/in/daniel-galbraith-26a6138Solvias website: www.solvias.comEmail: daniel.galbraith@solvias.comNext step:Book a 20-minute call to help you get started on any questions you may have about bioprocessing analytics: https://bruehlmann-consulting.com/callPreparing for your IND? Grab our Startup Founder CMC Dashboard in Notion to help you track tasks, timelines, and risks in one place at https://stan.store/SmartBiotech/p/discovertoind-cmc-dashboard-for-startup-founders
Welcome to the Paint The Medical Picture Podcast, created and hosted by Sonal Patel, CPMA, CPC, CMC, ICD-10-CM.Thanks to all of you for making this a Top 15 Podcast for 5 Years: https://blog.feedspot.com/medical_billing_and_coding_podcasts/Sonal's 16th Season starts up and Episode 10 features a Newsworthy spotlight on November as Lung Cancer Awareness Month.Sonal's Trusty Tip and compliance recommendations focus on telehealth updates made in the CY 2026 Medicare Physician Fee Schedule Final Rule. Spark inspires us all to reflect on resilience based on the inspirational words of Margaret Thatcher.Lung Cancer Awareness Month:American Lung Association® Website: https://www.lung.org/lung-force/about-lung-force/featured-campaigns/lung-cancer-awareness-monthPaint The Medical Picture Podcast now on:Spotify: https://open.spotify.com/show/6hcJAHHrqNLo9UmKtqRP3XApple Podcasts: https://podcasts.apple.com/us/podcast/paint-the-medical-picture-podcast/id1530442177Amazon Music: https://music.amazon.com/podcasts/bc6146d7-3d30-4b73-ae7f-d77d6046fe6a/paint-the-medical-picture-podcastFind Paint The Medical Picture Podcast on YouTube: https://www.youtube.com/channel/UCzNUxmYdIU_U8I5hP91Kk7AFind Sonal on LinkedIn: https://www.linkedin.com/in/sonapate/And checkout the website: https://paintthemedicalpicturepodcast.com/If you'd like to be a sponsor of the Paint The Medical Picture Podcast series, please contact Sonal directly for pricing: PaintTheMedicalPicturePodcast@gmail.com
Unlock your Week 10 fantasy football edge with 12 Must-Know Fantasy Football Stats for NFL Week 10! Keith Flemming and Kacey Kasem break down 12 must-know stats and trends to help you crush your lineup and waiver wire decisions. Whether you're rolling after a big Week 9 or battling back from a tough week, these insights give you the upper hand in your fantasy football leagues.(00:00) Intro (01:17) Brock Bowers(03:46) CMC(05:32) Drake London(07:16) Kyle Monangai(09:06) Rico Dowdle (11:14) Patriots Elite Run D(12:08) Bengals Pathetic Defense(13:47) Chargers Lose Joe Alt(15:38) Rasheed Shaheed to Seahawks!(18:20) This Bills Team Built For Playoffs?(23:40) Giants Backfield Subscribe for expert fantasy football advice, rankings, waiver wire pickups, and trade tips all season long! Like, comment, and hit the notification bell so you never miss our latest insights.
Columbus has rhythm, talent, and venues—but can it build a music industry that rivals Nashville, Austin, or Chicago? We explore Columbus' $1.3 BILLION local music economy and what it'll take to elevate it to national prominence. From local legends to industry insiders, we stagedive into strategy, investment, and how the city can turn homegrown talent into household names. Featuring: Bruce Garfield, Executive Director, Music Means Business Inc. Amy Holihan, Deputy Director, Music Columbus Natalie Jackson, Co-Founder, Natalie's Grandview Rashad Thomas, CEO, Elev8tor Music The host is Chris DeVille, Managing Editor, Stereogum, and Author of Such Great Heights: The Complete Cultural History of the Indie Rock Explosion. This forum was sponsored by Music Columbus. The presenting sponsor of the CMC livestream was The Center for Human Kindness at the Columbus Foundation. CMC's livestream partner was The Columbus Dispatch. This forum was also supported by Downtown Columbus, Inc. and The National Veterans Memorial and Museum. CMC's onsite book sales partner for this forum was Gramercy Books. Ready for even more rock reading? Our partners at the Columbus Metropolitan Library recommends checking out "Love, Death & Photosynthesis" (2021) by Bela Koe-Krompecher, founder of Anyway Records. This forum was recorded before a live audience at The National Veterans Memorial and Museum in Columbus, Ohio on November 5, 2025.
Finding an analytical CRO that's truly invested in your success, not just processing samples, makes all the difference in CMC development. In this episode, host David Brühlmann talks with Daniel Galbraith, Chief Scientific Officer at Solvias, about the essential questions and mindset that lead to breakthrough CRO partnerships.With nearly three decades in analytical development, spanning monoclonal antibodies, biosimilars, and cell and gene therapies, Daniel reveals what separates CROs who become true partners from those who just run methods. His insights can save your program months of delays and costly missteps.Key Topics Discussed:Why cell and gene therapies face unique challenges compared to the progression seen with monoclonal antibodies (03:04)Daniel's career path: from entering biotech in 1996 to CSO at Solvias, and the rapid evolution of the industry (05:00)The analytical hurdles in characterizing cell-based products and how their inherent variability impacts development (09:46)Approaches to analytical method requirements for autologous cell therapies, and how data is gathered iteratively in these cases (13:02)The biggest obstacles to scaling up cell and gene therapies, and why innovative cell manipulation technologies are needed (16:06)Current trends in therapeutic modalities: why antibody-drug conjugates stand out, and whether mRNA therapies are losing momentum (18:37)Practical advice on choosing an analytical CRO as a strategic partner - what to look for, what questions to ask, and why enthusiasm and standardization matter (21:55)Wondering how to streamline your own analytical strategy, or navigate the parallel universe of cell and gene therapy development? Dig into this episode for Daniel's insider perspective. Then consider how the right analytical partnership could accelerate your path to clinic.Connect with Daniel Galbraith:LinkedIn: www.linkedin.com/in/daniel-galbraith-26a6138Solvias website: www.solvias.comEmail: daniel.galbraith@solvias.comNext step:Book a 20-minute call to help you get started on any questions you may have about bioprocessing analytics: https://bruehlmann-consulting.com/callPreparing for your IND? Grab our Startup Founder CMC Dashboard in Notion to help you track tasks, timelines, and risks in one place at https://stan.store/SmartBiotech/p/discovertoind-cmc-dashboard-for-startup-founders
Steiny & Guru chat with NFL Audacy Insider Ross Tucker about the 49ers 6-3 start, what a move means for the rest of their season, a legit threat to the NFC West, and why no other player has more of Ross' respect than CMC.
(0:00) Vikings upset Lions(10:00) Bears come back, take down Bengals(17:00) Packers fall to Panthers(22:00) Seahawks dominate Commanders(30:00) Patriots edge out Falcons(35:00) Stafford shines over Saints(40:00) CMC too much for Giants(42:00) Broncos take down Texans(45:00) Chargers rally to defeat Titans(48:00) Jags def. Raiders in OT; K Cam Little makes NFL history(51:00) Arrow Up / Arrow Down: Week 9 Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Complete betting recaps and the top storylines of every NFL Week 9 game plus early handicapping and analysis for the Week 10 matchups — including Monday Night Football picks and best bets — with Patrick Meagher and Mike Somich.In This Episode:Seahawks blow out the Commanders — Jayden Daniels injured lateBears and Bengals combine for over 1,000 total yards — improbable Chicago win against historically bad Bengals defenseWeek 10 preview: Bears vs Giants; Bengals on bye49ers easily cover vs Giants — 49ers defense struggling, CMC has a big gameWeek 10 preview: 49ers vs Rams — Rams are the better team than 49ers.Week 10 preview: Giants at Bears — Mike likes the over.Falcons at Patriots — a gut check for New England, Falcons cover every numberWeek 10 preview: Falcons vs Colts in Europe — Colts dropped a level after loss at Pittsburgh.Week 10 preview: Patriots at Buccaneers — are the Patriots for real?Steelers stun Colts — turnovers the story, Steelers defensive line dominates strong offensive line.Week 10 preview: Steelers at Chargers — will we see the same Steelers?Packers lose at home vs Panthers as heavy favorites — more of a Packers loss than a Panthers win.Week 10 preview: Packers vs Eagles on Monday Night Football — line moving towards Eagles.Week 10 preview: Panthers vs Saints — big line move to Carolina, Panthers untrustworthy; Saints could look different after trade deadline.Vikings beat Lions as 9.5-point underdog — JJ McCarthy played better than his stat line, Vikings blitz rattled Lions' offense.Week 10 preview: Lions at Commanders — Bet Lions -3 nowWeek 10 preview: Ravens at Vikings.Broncos edge Texans in Houston — Bo Nix does it again in 4th quarter, CJ Stroud knocked out with concussion.Week 10 preview: Broncos vs Raiders on Thursday Night Football, Brock Bowers makes this interestingTexans vs Jaguars — under is the best bet.Chargers beat Titans — Tennessee covers; Joe Alt injury is significant.Week 10 Steelers at Chargers — take 3.5 with Pittsburgh; Steelers d-line could be a problem for Chargers o-line.Jaguars win but don't cover in overtime vs Raiders — Brock Bowers makes huge difference; Mike and Patrick skeptical of Jaguars.Week 10 preview: Jaguars at Texans — CJ Stroud playing would be a surprise.Rams destroy Saints — good teams do what they do; Rams will get better.Saints should trade what they can.Week 10 preview: Saints at Panthers — Carolina shaky favorite; game is in a dead zone.Week 10 preview: Rams at 49ers — Rams motivated after last loss; bet Rams -3 now.Bills vs Chiefs — Bills played like it was their Super Bowl, Bills defensive line masterclass, Chiefs offensive line needs to get healthy.Week 10 preview: Bills at Dolphins — bet Bills if Dolphins sell at trade deadline.Seahawks dominate Commanders — Seattle is an ultra-balanced team.Week 10 preview: Seahawks vs Cardinals — Mike likes Seahawks -6.5.Monday Night Football betting preview: Cardinals at Cowboys — bet Cowboys to make the longest field goal at -105.Get sharp insights, betting angles, and entertaining analysis from Patrick Meagher and Mike Somich every week on the Sharp Money Podcast — new episodes drop every Monday and Thursday.VSiN is THE Sports Betting Network — delivering the latest news, analysis, and expertise about sports gambling.
JMToWin from One Week Season walks us through the Week 9 DFS slate from a GPP perspective, shares his top plays at each position, and then builds a DraftKings lineup using some of his favorite building blocks. In the second half, Youdacao from Run The Sims join to discuss sneaky stacks for Week 9 tournaments and input volatility.
What if the answer to battling antibiotic-resistant infections isn't a new antibiotic, but harnessing viruses that have been quietly dominating bacterial populations?Bacteriophages, viruses that target and kill bacteria, have been saving lives for a century, but their true potential is only now being unlocked by modern machine learning. The race isn't just about discovering effective phages; it's about deploying the right therapy, personalized to the patient, before time runs out.On this episode, David Brühlmann welcomes José Luis Bila, Co-Founder and CEO of Precise Health. Driven by personal tragedy and an engineer's mindset, José is shaping a future where AI-powered phage therapy isn't a niche solution, but a scalable, accessible weapon against the superbugs that evade antibiotics. From building bioreactor capacity to navigating regulatory gray zones, José brings a rare blend of technical vision and practical urgency to a problem that affects families and health systems worldwide.Key topics discussed:The challenge of evolving bacteria and phages, and the question of whether it's possible to keep up with nature's pace through engineering new phages in silico (00:00)Overview of bacteriophage production: complexity, types of bioreactors used, and comparison with chemical synthesis (02:54)Bioproduction logistics: using CDMOs vs. in-house hospital production and the real-world timescales for manufacturing (02:32)Barriers for smaller or less funded hospitals, especially in low- and middle-income countries, with thoughts on hospital infrastructure differences worldwide (04:41)Creative solutions for cost-effective phage production in remote and underserved regions, such as the potential for single-use or mobile bioreactors (06:01)Why downstream processing and ensuring product purity is a bottleneck; the need for miniaturization and economic scalability (06:40)Parallels and differences in downstream processing between bacteriophages and viral vectors (09:15)The vital role of stability and shelf life for phage therapy logistics and economic viability (09:15)Regulatory pathways for phage therapy in Europe and beyond, including magistral preparations, ethical approvals, and adapting to digital tools for selection (12:39)The future vision: routine clinic entry through matching existing phage libraries, with longer-term goals of engineering bespoke phages via AI when necessary (15:52)José's perspective on building global infrastructure and making phage therapy cost-effective and universally accessible (18:08)José Bila's message: solutions to antimicrobial resistance are within reach. The biotech community must build accessible infrastructure, using AI and innovative systems to ensure phage therapy benefits reach every patient, everywhere.Connect with José Luis Bila:LinkedIn: www.linkedin.com/in/josé-luis-bila-phd-3b08a5a7Precise Health SA: www.precisehealth.ioInterested in how scientists are fighting superbugs? Learn how phage therapy and smart bioprocess design are helping outmaneuver drug-resistant pathogens. Check out this interview with one of our previous guests!Episodes 187-188: From Biology Is Messy to Designable: The Smart Bioprocessing Transformation with Carmen Jungo RhêmeNext step:Book a 20-minute call to help yo
Send us a textThe Giants face their toughest test yet — the injury-riddled 49ers are coming to town, and everything is on the line for Big Blue.Which storyline has you fired up most: Malik Nabers' surgery, Dexter Lawrence firing back at Carl Banks, or Cam Skattebo's road to recovery? Tell us below and don't forget to hit Subscribe to join the Goofball Army!Nabers finally underwent surgery a full month after his knee injury, calming fans worried about his long-term future. While the recovery timeline keeps him out until 2026 training camp, his surgery went smoothly — a key milestone for one of NY's cornerstone stars.Meanwhile, Dexter Lawrence lit up headlines after former Giants legend Carl Banks claimed opponents “don't respect” him anymore. Lawrence fired back hard, pointing to being double-teamed on over 72% of snaps and his rising 13.5% pass-rush win rate. The tape agrees — he's still drawing elite-level attention. The real issue may lie in scheme changes that moved him away from his most dominant spot at nose tackle.Then there's the brutal injury to Skattebo. Ian Rapoport reported that the rookie back suffered a dislocated ankle, fibula fracture, and ligament rupture, requiring immediate surgery. Doctors say recovery should take roughly six months, meaning Skattebo should return by OTAs. Despite the gruesome moment, the outlook remains encouraging.We'll also preview this week's showdown with the 49ers — a team somehow sitting 5-3 despite 22 injuries across their roster. Saleh's defense remains tough, CMC continues to carry the offense, and Brock Purdy's status looms large. The Giants' keys to victory are simple: contain CMC, finish in the red zone, create pressure, and stretch the field deep when protection allows.Thank you for watching & for your support. You made it to the bottom of the description so you must like the show!Show Everyone You are a Goofball By Checking Out Our Merchandise Storehttps://2giantgoofballs-shop.fourthwall.com/Support the Show on Buy Me a Coffee – Kill Our Livers Buy Us Beers!https://buymeacoffee.com/2giantgoofballsSubscribe to Our YouTube Channel – Best Way to Watch Our Contenthttps://www.youtube.com/@2giantgoofballs?sub_confirmation=1Become a Member of the YouTube Goofball Channel for Perkshttps://www.youtube.com/channel/UC-tiLjkehiawtN-v6gMFViA/joinFollow us On Facebookhttps://www.facebook.com/2giantgoofballsFollow us On Xhttps://x.com/2giantgoofballsPrefer Audio Only? Check Out Those Options Herehttps://2giantgoofballs.buzzsprout.com/#nygiants #giants #newyorkgiants #giantsfootball #nygiantsfanSupport the show
Welcome to the Paint The Medical Picture Podcast, created and hosted by Sonal Patel, BA, CPMA, CPC, CMC, ICD-10-CM.Thanks to all of you for making this a Top 15 Podcast for 5 Years: https://blog.feedspot.com/medical_billing_and_coding_podcasts/Sonal's 16th Season starts up and Episode 9 features Newsworthy updates on the month's fraud, waste, and abuse cases. Sonal's Trusty Tip and compliance recommendations focus on diagnosis coding for family history of breast cancer.Spark inspires us all to reflect on resilience based on the inspirational words of Maya Angelou.Paint The Medical Picture Podcast now on:Spotify: https://open.spotify.com/show/6hcJAHHrqNLo9UmKtqRP3XApple Podcasts: https://podcasts.apple.com/us/podcast/paint-the-medical-picture-podcast/id1530442177Amazon Music: https://music.amazon.com/podcasts/bc6146d7-3d30-4b73-ae7f-d77d6046fe6a/paint-the-medical-picture-podcastFind Paint The Medical Picture Podcast on YouTube: https://www.youtube.com/channel/UCzNUxmYdIU_U8I5hP91Kk7AFind Sonal on LinkedIn: https://www.linkedin.com/in/sonapate/And checkout the website: https://paintthemedicalpicturepodcast.com/If you'd like to be a sponsor of the Paint The Medical Picture Podcast series, please contact Sonal directly for pricing: PaintTheMedicalPicturePodcast@gmail.com
From October 20-23, the Central Committee of the Chinese Communist Party held its Fourth Plenum in Beijing, marking an important moment as the Party sets the direction for China's development for the next five years. The session adopted recommendations for the 15th Five-Year Plan, endorsing Xi Jinping's goals of high-quality development, scientific and technological self-reliance, and strengthening national security in response to rising global instabilities. The Central Committee also announced the replacement of 11 members, the highest personnel turnover since 2017 amid an ongoing anti-corruption purge in the military. To discuss the plenum's outcomes, we are joined by Jonathan Czin. Jonathan is a leading expert on Chinese politics and foreign policy. He holds the Michael H. Armacost Chair in Foreign Policy Studies and is a fellow in the John L. Thornton China Center at the Brookings Institution. He previously led the intelligence community's analysis of Chinese politics and policy making at the CIA and also spent two years as director for China at the National Security Council during the Biden administration. Timestamps: [00:00] Start [01:36] Why the Fourth Plenum Matters [03:37] Key Takeaways: Policy Continuity and Political Purges [05:07] Zhang Shengmin and Xi Jinping's Military Ambitions [09:23] Signals and Adjustments in Economic Planning [11:56] Previewing the 15th Five-Year Plan [13:33] Xi Jinping's Growing Confidence [17:42] Political Messaging and Choreography [20:21] Language in the Communique: “Strategic Resolve” [22:28] What to Expect from the Xi-Trump Summit [26:38] Is Beijing Worried the Summit Could Backfire?
Antibiotic resistance isn't just a looming problem. It's a global crisis. Every year, more than one million people die directly from resistant infections, and another 5 million die indirectly. Routine infections are becoming life-threatening, and healthcare systems worldwide are under pressure.Despite decades of warnings, pharmaceutical solutions are falling behind, while “superbugs” continue to outpace new drug development. If trends continue, by 2050, antibiotic resistance could claim 10 million lives annually and cost the world $1 trillion.Meet José Luis Bila, a chemist-turned-biotech-founder, who transformed personal tragedy into a mission to disrupt this deadly status quo. After losing both parents to antibiotic-resistant infections, José dedicated his career to the search for targeted, effective alternatives. Now, as Co-Founder and CEO of Precise Health SA, he's building AI-powered bacteriophage therapy platforms that promise to revolutionize personalized infection treatments and outmaneuver today's most stubborn bacteria.Why tune into this episode? Here are three standouts from José's story and his technical playbook:José's personal story: Losing both parents to antibiotic resistance and its impact on his career path. (00:00)Scope of the antibiotic resistance crisis: Global deaths, indirect impacts, and economic cost projections. (06:29)Why big pharma is pulling out of antibiotic development and why innovation may come from smaller startups. (07:29)Why antibiotic resistance persists: Static nature of antibiotics versus adaptable bacteria, and misuse of antibiotics. (09:45)Introduction to bacteriophage therapy and its specificity challenges. (11:46)The current slow, manual process for matching phages to infections and its limitations in urgent clinical settings. (13:08)How machine learning is being used at Precise Health to rapidly identify and source the right phages using genetic information. (16:58)The potential to reduce phage matching and delivery time from months to just days, and how smart batching and regional surveillance improve economics. (17:23)José Luis Bila's journey shows the power of science driven by purpose. Through persistence, he's pioneering AI-driven phage therapy - offering precision, hope, and a potential lifeline in the fight against antibiotic-resistant infections.Connect with José Luis Bila:LinkedIn: www.linkedin.com/in/josé-luis-bila-phd-3b08a5a7Precise Health SA: www.precisehealth.ioInterested in how scientists are fighting superbugs? Learn how phage therapy and smart bioprocess design are helping outmaneuver drug-resistant pathogens. Check out this interview with one of our previous guests!Episodes 187-188: From Biology Is Messy to Designable: The Smart Bioprocessing Transformation with Carmen Jungo RhêmeNext step:Book a 20-minute call to help you get started on any questions you may have about bioprocessing analytics: https://bruehlmann-consulting.com/call
FOLLOW UP: IMPACT OF JLR SHUTDOWNProfessor David Bailey has written up a piece on Blogs from the Blackstuff following a report from the Cyber Monitoring Centre (CMC), which outlines the cost of the JLR shutdown and it is large. The estimated cost is in the region of £1.9 billion but could be as high as £2.1 billion. Over 5,000 businesses were affected. The CMC hopes businesses, the Government and insurers to learn lessons. To read more, click this article link here. NEW CHIP CRISIS LOOMINGAnother week and another example of how crucial China is to making things. This time there is a spat between Dutch and the Chinese Governments over the chip maker Nexperia after the Chinese CEO was removed and the European country took control of the company. They supply a lot of the car industry, particularly the electric car making segment. China has restricted exports of their chips, which means the company cannot guarantee reliable supply. For more on this story, click this link to an electrive article here. PORSCHE PROFITS PLUMMET AGAINPorsche has released their financial results for the last quarter and they are, once again, poor. They had an operating loss of €966 million, with return on sales for the year dropping to just 0.2% after being 14.1% the year before. Click this Piston Heads article link here, for more. FORD EUROPE FINDS A NEW BOSSFord Europe are to get a new president, Jim Baumbick, who moves from global head of product development and head of advanced product development. He takes the reigns on 1 November 2025. The role has been vacant for some time. If you want to read more, click this electrive article link here. UK GOVERNMENT HELP TOYOTA BUILD A CARToyota is receiving £15 million investment from the UK Government to explore the feasibility of bringing their FT-Me Concept to market. Think IQ size and it being a quadracycle, with the idea of it being used in high density urban areas. You can find out more, by clicking this Autocar article link here. WAYMO SELF-DRIVING CARS TO TEST IN LONDONWaymo is bringing some of their autonomous vehicles to London, to take part in a Government backed trial. They will join Uber, in the spring. For more on this story, click this Autocar link. For some context, here is a link to a Bluesky thread that demonstrates had bad Waymo is at autonomous driving (and it is the least worst at it!). LORDS PUSH FOR ACCESSIBILITY AT EV CHARGERSThe House of Lords has backed an amendment to the Planning and Infrastructure Bill, that would make accessibility standards legally binding for EV chargers if approved in the House of Commons. Click this link from EV Powered to read more. If you like what we do, on this show, and think it...
Your process works perfectly at two-liter bench scale. Then you hit fifty liters and titer drops 20%. By two hundred liters, aggregation appears and charge variants shift. Your management team asks: "How long to fix this?" The honest answer? Three to twelve month, because you're flying blind.In Part 2 of this Quality by Design Master Class, David Brühlmann reveals why scale-up chaos isn't inevitable. It's a solvable engineering problem. Drawing on experience leading bioprocess innovation at Merck and guiding biotech companies through CMC development, David delivers the process control framework that transforms reactive troubleshooting into predictive manufacturing.The core truth: eighty percent of quality problems stem from twenty percent of your process variables. David shows how to identify Critical Process Parameters, implement intelligent control strategies, and leverage hybrid modeling that reduces experiments by 60-80%. With case studies from Genentech and Amgen, you'll gain the blueprint that turns QbD requirements into competitive advantage.Part 1 taught you what to build and measure. Part 2 shows you how to control your process to consistently deliver commercial-scale quality.Topics Discussed:The common pitfalls of scaling up manufacturing from bench to production, and why process control must go beyond end-product testing (02:10)Overview of the QbD framework: Quality Target Product Profile (QTPP), Critical Quality Attributes (CQAs), and the focus of this episode - Control Strategies for manufacturing (05:00)Identifying and monitoring Critical Process Parameters (CPPs) and their impact on quality, with real-world examples from Genentech's monoclonal antibody platform (08:20)Structure of an effective manufacturing control strategy: Input, process, and output controls - including practical details on real-time monitoring and release testing (11:00)The role of hybrid modeling and machine learning in accelerating process optimization, and how this approach can dramatically reduce the experimental burden (13:30)Real examples of improved outcomes and efficiency through model-based control strategies, and why training and process understanding are essential for team success (16:10)A quick, actionable exercise biotech teams can use to map process risks and identify critical control points (16:55)Whether you're part of a start-up or a large biotech firm, this episode offers clear, strategic steps for implementing QbD and improving process reliability. Don't forget to listen to Part 1 for more on QTPP and CQA, and visit www.bruehlmann-consulting.com for additional resources.Next step:Book a 20-minute call to help you get started on any questions you may have about bioprocessing analytics: https://bruehlmann-consulting.com/callPreparing for your IND? We're building a CMC Dashboard in Excel to help biotech founders track tasks, timelines, and risks in one place. Join the waitlist for early access at https://scale-your-impact.notion.site/27dd9c6ba679804b80a7ce439d56c91a?pvs=105
Damon Bruce Plus: Warriors, 49ers, Giants, A’s Bay Area Sports Talk
2:25: Dramyond on Jimmy and alphas:7:30: The No. 1 alpha dog in the Bay Area right now? CMC. But how about George Kittle, too?9:04: Steph is the best Warrior ever — but really isn't an alpha dog18:10: The Giants have a new manager, and it's a first. So, good luck, Buster, because your reputation rests on this.25:12: The flip-around rant:33:36: The NFL knew exactly what it was doing by choosing Bad Bunny for the Super Bowl Halftime Show:42:20: Today in history: Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Welcome to the Paint The Medical Picture Podcast, created and hosted by Sonal Patel, CPMA, CPC, CMC, ICD-10-CM.Thanks to all of you for making this a Top 15 Podcast for 5 Years: https://blog.feedspot.com/medical_billing_and_coding_podcasts/Sonal's 16th Season starts up and Episode 8 features a Newsworthy update on claims being held by Medicare.Sonal's Trusty Tip and compliance recommendations focus on percutaneous needle breast biopsies.Spark inspires us all to reflect on resilience based on the inspirational words of Marianne Williamson.Checkout the Workshop for Telehealth Playbook for 2025-2026 on: https://kwadvancedconsulting.com/training-education-2/on-demand-webinars/webinar-registration/Paint The Medical Picture Podcast now on:Spotify: https://open.spotify.com/show/6hcJAHHrqNLo9UmKtqRP3XApple Podcasts: https://podcasts.apple.com/us/podcast/paint-the-medical-picture-podcast/id1530442177Amazon Music: https://music.amazon.com/podcasts/bc6146d7-3d30-4b73-ae7f-d77d6046fe6a/paint-the-medical-picture-podcastFind Paint The Medical Picture Podcast on YouTube: https://www.youtube.com/channel/UCzNUxmYdIU_U8I5hP91Kk7AFind Sonal on LinkedIn: https://www.linkedin.com/in/sonapate/And checkout the website: https://paintthemedicalpicturepodcast.com/If you'd like to be a sponsor of the Paint The Medical Picture Podcast series, please contact Sonal directly for pricing: PaintTheMedicalPicturePodcast@gmail.com
Want to stay up to date on LCMS Happenings from Pastor Tim?Join the LCMS Current: https://www.uniteleadership.org/thelcmscurrentThe LCMS is wrestling with a familiar question: are we keeping distinctions or breaking barriers?Pastor Tim Ahlman, Jack Kalleberg, and Pastor Jonathan Dinger return to one of Lead Time's most popular conversations—this time reframed around access.- What does it mean to create access to the Gospel without compromising theological depth?- How do local contexts—from Arizona to Idaho—shape the way churches live out the confessions?- And what happens when fear, control, or mistrust shape our leadership more than faith and freedom?
Baldy joins The Roast to talk about the loss on defense of Bryce Huff, plus the return of explosive CMC runs and if the 49rs can win the NFC West with Mac Jones under center
THANKS FOR WATCHING! DON'T FORGET TO SUBSCRIBE TO OUR CHANNEL Get in on the action with BETR Picks! Click our link: https://engagebetr.onelink.me/auSX/BENCHD Or use our CODE: “BENCHD” BETR will match 1st deposit up to $250!!! SPORTS JUST GOT BETR VISIT BENCHDSHOW.COM - Special Announcements - Fantasy Rankings and Tips - The BENCH'd Beat - Sign up for our weekly email ————— NFL Podcast | New Episodes 3x a week FOLLOW THE SHOW Instagram: https://www.instagram.com/benchdshow TikTok: https://www.tiktok.com/@benchdshow Twitter: https://twitter.com/benchdshow Spotify Podcasts: https://podcasters.spotify.com/pod/show/benchdshow Apple Podcasts:https: podcasts.apple.com/us/podcast/benchd-w-the-tovar-brothers-nfl/id1692285587 ————- SHOP FAT BROTHERS https://fatbrothersfoods.com?sca_ref=9522676.RQeKd6HiGTuw2 —————- SHOP AT: DAD GANG HATS https://www.dadgang.co USE CODE: BENCHD76826 ------------ 0:00 Intro 2:20 Happy Birthdays 4:56 BENCHIES 5:06 Matthew Stafford BALLIN 6:08 Mike Vrabel revenge game 6:52 Former Raiders HC Antonio Pierce 8:00 Brandon Aubrey breaker of records 8:46 Broncos vs Giants trash talk 10:15 Dolphins franchise meltdown 11:28 The Ass Class 18:35 Rams defeat Jaguars 19:39 Travis Hunter needs to stay WR 21:49 Bears defeat Saints 22:45 Bears heat check 23:29 Browns defeat Dolphins 25:11 Patriots defeat Titans 26:35 Is Cam Ward a bust? 28:11 Chiefs defeat Raiders 28:40 Chiefs are BACK 30:43 Eagles defeat Vikings 31:18 Jalen Hurts MVP? 37:19 Vikings heat check 39:17 Panthers defeat Jets 39:59 Aaron Glenn hot seat 40:54 Broncos defeat Giants 41:36 Broncos are massive frauds 47:52 Colts defeat Chargers 48:47 Chargers are the same old Chargers 53:40 Cowboys defeat Commanders 54:00 Commanders never had a shot 56:11 Cowboys offense is ELITE 58:01 Packers defeat Cardinals 58:27 Cardinal must move on from Kyler Murray 1:00:44 49ers defeat Cardinals 1:03:52 CMC won't last 1:06:42 Mailbag Monday Learn more about your ad choices. Visit megaphone.fm/adchoices
Damon Bruce Plus: Warriors, 49ers, Giants, A’s Bay Area Sports Talk
49ers get vintage CMC in a win over the Falcons Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.
Damon Bruce Plus: Warriors, 49ers, Giants, A’s Bay Area Sports Talk
2:19: Once again, the 49ers live to die another day5:50: There is not one great team in the NFL, which means a “pretty good team”, like the 49ers, is gonna win it all7:51: The 49ers are right in this — so it's time to make a big move17:01: Fred Warner's jersey + Tatum Bethune — this kid might just be it25:40: ALCS Game 7 is the biggest game of the night — Sorry, MNF doubleheader35:32: Today in history: Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
10-20 49ers reporter, Matt Barrows joins Papa & Silver to break down the Niners huge win vs the Falcons on Sunday Night Football behind a steamy CMC & killer defensive performanceSee omnystudio.com/listener for privacy information.
10-20 Former NFL QB Todd Husak weighs in on appreciation for CMC while he is dominant & why he sees the 49ers as a contender despite injuriesSee omnystudio.com/listener for privacy information.
We love to hear from our listeners. Send us a message. On this week's episode of the Business of Biotech -- part three in a four part series recorded in-person at Catalyst Pharmaceuticals' Miami headquarters -- Anthony Japour, M.D., CEO at iTolerance, talks about his work as a physician treating infectious diseases, his CEO role in diagnostics at the height of the COVID-19 pandemic, what he learned working as a medical director at a large CRO, and iTolerance's work toward a cure for Type 1 diabetes that doesn't require chronic immunosuppression. Anthony also provides insights on overcoming CMC challenges and how to bypass avoidable detours, the funding climate for preclinical biotechs, and operating in South Florida. Access this and hundreds of episodes of the Business of Biotech videocast under the Business of Biotech tab at lifescienceleader.com. Subscribe to our monthly Business of Biotech newsletter. Get in touch with guest and topic suggestions: ben.comer@lifescienceleader.comFind Ben Comer on LinkedIn: https://www.linkedin.com/in/bencomer/
Andy and Randy get in to the keys for the Falcons to beat the 49ers, and as banged up as the niners are, Atlanta just can't let CMC run wild.
Andy and Randy start looking forward to the Falcons Sunday Night Football game vs the 49ers, and while the 49ers have said that they practice for Bijan Robinson, there is no way to simulate playing against him in any practice, even with CMC.
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