Podcasts about melanocyte

This 1993 song gives focus to so much, including emotional men struggling with their feels (or their apathy) and their words. How can the Smooth music listener contend with the voice of Satan and still get to yoga on time? Childhood mini-traumas. The Ying and Yang of Hair and skin pigments. Canadian contributions to culture and the cinematic climax of Dumb and Dumber. Pretentious use of the word "vignette". Othering. C+C Music Factory and Arsenio Hall. The inertia of hair colour. Biosafety. PentaCostco and godly or Nazi salutes. The mystery of skin and hair conditions, and the bigger mystery of "reaction videos". Albino witchcraft and preventative murder in Africa. Corrective Frankenstein shoes. Empathy-gasms. Extra teeth and extra toes. Total Recall mutations. Weird Al Yankovic. Venom versus the Melanocyte. Marie Antoinette. Stem cells. Cancel culture and cosmetic clinics. Anal probes. Who hasn't seen "Sling Blade"? Audio soundscapes of pizza. Door handle life-hacks. Would you like to appear (well, vocally) on the show? Do you have a pop song or ear-worm from the SMOOTH FM genre that's infested your mind and needs to be investigated? Visit this page anchor.fm/peter-davis6 and press the message button to record me your own voicemail hot-take on your specific smooth song of suckiness. You can be on a future episode! (you can always email sound files or text your thoughts to poidadavis@gmail.com if that's easier). Cheers! Sound clips are included for educational reference, criticism, satire and parody in fair use. Clips remain the property of the respective rights holder and no endorsement is implied. All information and opinion is performed and expressed in-character and does not reflect reality or genuine commentary on any persons (living or dead), bands or other organisations, or their works, and is not recommended listening for anyone, anywhere.

Episode 11 features Dr. April Schachtel and Dr. Katherine Stiff reviewing the following recent publications:Oh SJ, Lee J, Lee JH, Bae J, Park JH, Lee JH, Lee D. Distribution of cellular remnants of melanocytes in the nail plate: Clue to the diagnosis of subungual melanoma. Journal of Cutaneous Pathology.2021[Epub ahead of print].Vedamurthy M, Raghupathy S, Vanasekar P. Use of ultrasound gel to increase efficacy of cryotherapy in treatment of warts. J Am Acad Dermatol. 2021 [Epub ahead of print].Cai W, Wu C, Peng J, Chen M. “Application of Forceps in The Operation of Nail or Toenail. J Am Acad Dermatol. 2021 [Epub ahead of print].

Marie Antoinette's hair suddenly turned white before the ill-fated French queen was taken to the guillotine to have her head chopped off, according to some historical accounts.More modern reports refer to hair turning prematurely white in survivors of bomb attacks during World War II, while an Australian airline pilot saw his hair go grey in the months after landing a plane following a failure of all four engines in the early 1980s.While there's been plenty of anecdotal evidence suggesting premature greying can be caused by extreme stress -- whether this is true and how this happens isn't widely understood.Now, Harvard University scientists think they have the answer -- at least in mice.The group of researchers believe it's down to the animal's sympathetic nervous system -- which is best known for activating our "fight or flight" response to danger, they say."Under stress, our sympathetic nerve becomes highly activated," said Ya-Chieh Hsu, associate professor of stem cell and regenerative biology at Harvard, in an email. "And actually, activation of the sympathetic nervous system under stress is supposed to be a good thing."Its activation triggers the "fight or flight" response through the neurotransmitter norepinephrine, or noradrenaline, explained Hsu, a senior author of the study published Wednesday in the scientific journal Nature. "Noradrenaline raises our heartbeat and allows us to react quickly to danger without having to think about it," he said."However, it is the same noradrenaline that turns out to be bad for melanocyte stem cells at a high level, and triggers their loss."Melanocyte stem cells are found in hair follicles and determine hair colour. In people, the pool of these cells deplete as they age, turning hair grey as pigment depletes. Their loss from excessive noradrenaline could be causing this to happen prematurely, the team suggest.Loss of pigmentThe team had thought that acute stress might trigger an immune attack on pigment-producing stem cells or that the blame lied with the hormone cortisol because cortisol levels are elevated under stress. Hsu said they went through many different possibilities before focusing on the sympathetic nervous system."We were really surprised to find that it was the culprit, because it is normally seen as a beneficial system, or at least transient and reversible," she said.The team put mice under three different types of stress through what Hsu described as established standard protocols. These included a single injection of a chemical to activate the mouse's pain fiber, cage tilting and rapid changes between light and dark.Changes were observed in all mice but there was some variability, with white hair only coming out after all the stem cells are gone."Some hair follicles have reduced levels of melanocyte stem cells so they can still make pigment, while others have lost all stem cells and can't make pigment anymore, so the hair becomes white," she said.Pigment-producing stem cells and the sympathetic nervous system are very similar in mice and humans, explained Hsu who was hopeful that the mechanisms would be related. But future studies would be needed to provide definitive evidence, she said."Everyone has an anecdote to share about how stress affects their body, particularly in their skin and hair — the only tissues we can see from the outside," Hsu said in a news release."We wanted to understand if this connection is true, and if so, how stress leads to changes in diverse tissues. Hair pigmentation is such an accessible and tractable system to start with — and besides, we were genuinely curious to see if stress indeed leads to hair greying."Hsu said the findings may also help shed light on the effects of stress on various organs and tissues, and pave the way for new studies that seek to modify or block the damaging effects of stress.In an accompanying article, Shayla Clark and Christopher Deppmann, researchers from the Neuroscience Graduate Prog...

Dr. Sharon Fekrat of Duke University joins to discuss her research on alpha-melanocyte stimulating hormone and macular disease, training vitreoretinal fellows, and more. Financial Disclosures: Dr. Sridhar has received consulting fees from Alcon, Alimera Science, and Oxurion. Dr. Fekrat receives patent royalties from Alcon.

Part 2 of how NUTRITION has a HUGE impact on your BRAIN! Everything in your brain is something you ate, something you made from something you ate, or, in a few cases, something your mother ate. Nutrition impacts your mental and emotional health, the function of your five senses, and your conscious and unconscious control over your body movements. Join me as I lead you in a safari through the textbook, “Neuroscience,” pointing out along the way all the interesting connections to nutrition. Listen in for part 2 on the NEUROTRANSMITTERS! Get all four episodes right now, ad-free, and with transcripts. Sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code “CHRIS15” at checkout for a 15% discount off your first order.” In this episode, you will find all of the following and more: Nutrition in Neuroscience Show Notes 00:36 Cliff Notes 10:15 Overview of neurotransmitters 12:55 Glutamate is the primary excitatory neurotransmitter. 20:08 De novo glutamate in the central nervous system is overwhelmingly made from glucose. 22:55 Ketogenic diet for epilepsy 26:12 Glutamate metabolism 29:42 There are two classes of glutamate receptors: ionotropic and metabotropic. 30:45 There are three classes of metabotropic glutamate receptors, their actions are complex and variable, and they can be excitatory or inhibitory. 31:04 The ionotropic glutamate receptors include AMPA receptors, NMDA receptors, and kainite receptors, all of which have a depolarizing effect by allowing sodium and potassium to flow freely through them. 33:47 Four unique things about the NMDA receptor: magnesium is required to block its ion channel, it’s important for coincidence detection, it allows calcium to come into the cell, and it has a glycine-binding site. 39:16 Long-term potentiation (LTP) and long-term depression (LTD) are important for forming memories, and glutamate receptors play an important role. 46:48 GABA and glycine are the two primary inhibitory neurotransmitters of the central nervous system. 50:04 GABA and presumably glycine can be stimulatory if there is more chloride on the inside of the neuron than the outside. 54:52 Evidence that GABA might cross the blood-brain barrier 57:43 GABA in foods 01:00:14 GABA metabolism in the nervous system 01:02:07 Glycine 01:08:01 Acetylcholine 01:13:49 The biogenic amines include histamine, serotonin, and the catecholamines (dopamine, norepinephrine, and epinephrine). 01:14:30 Synthesis of the catecholamines 01:16:45 Dopamine 01:20:07 Norepinephrine 01:22:31 Histamine 01:26:14 Serotonin 01:29:10 ATP and adenosine 01:32:37 Peptide neurotransmitters 01:32:59 Hypothalamic releasing hormones include thyrotropin-releasing hormone (TRH), corticotropin-releasing hormone (CRH), and gonadotropin-releasing hormone (GnRH). 01:35:14 Melanocyte-stimulating hormone (MSH) 01:35:31 Oxytocin 01:36:18 Vasopressin 01:36:56 Synthesis of the neuropeptides Substance P, MSH, oxytocin, and vasopressin requires glycine, zinc, copper, and    vitamin C. 01:40:23 Endocannabinoids and the importance of arachidonic acid, EPA, and DHA

Sarah Tishkoff joins Nels and Vincent to explain work from her laboratory on the genetic basis of skin pigmentation in Africans. Hosts: Nels Elde and Vincent Racaniello Guest: Sarah Tishkoff Become a patron of TWiEVO Molecular Evolution and the Cell meeting Sarah AMA on Reddit Genetics of African skin pigmentation (Science) Image credit Science Picks Nels - In Defense of Plants (Shrew Loo) Vincent - Contribution of NIH funding to new drug approvals Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

Hosts: Nels Elde and Vincent Racaniello Guest: Hopi Hoekstra Nels and Vincent speak with Hopi Hoekstra about her career and the work of her laboratory on developmental mechanisms of stripe patterns in rodents.  Become a patron of TWiEVO Hoekstra Laboratory Hopi on Twitter Mechanisms of stripe patterns in rodents (Nature) Image credit Letters read on TWiEVO 15 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free – WITH FREE SHIPPING – by going to blueapron.com/twie. Science Picks Hopi -Diversify EEB, Anne's List Nels - Celebration for Harry Noller Vincent - Biological Warfare, Virus Style (journal article) Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

Exploiting crosstalk between signaling pathways may lead to more effective melanoma therapies.

TRPM1 is a cation channel found on vesicular membranes and associated with melanin content in melanocytes.