The composite of the organism's observable characteristics or traits
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In this thrilling installment of Impact Theory, Tom Bilyeu sits down with Ben Lamm, visionary founder and CEO of Colossal Biosciences, a company on a mission to reverse extinction and rewrite the future of conservation and synthetic biology. Ben and Tom dive deep into the mind-bending world of de-extinction, synthetic gene editing, and how the CRISPR revolution is not only unlocking the secrets of life—but also actively engineering it. In Part 1, get ready for a rollercoaster of concepts as Ben explains the technical magic behind gene editing, DNA synthesis, and multiplex genome editing. From the birth of the woolly mouse to the debated revival of dire wolves, Ben reveals the breakthroughs, challenges, and wild stories behind reviving extinct species. You'll learn how Colossal is using advanced computational biology, AI, and hands-on bioengineering to not only bring animals back but also reshape the future of healthcare, genetics, and ethical decision-making. This is part sci-fi, part practical science, and 100% mind-blowing. SHOWNOTES 00:00 – Kicking Off: The Mysteries of Editing Life 00:14 – Emergence of the CRISPR Revolution 01:31 – What Is DNA Synthesis and Multiplex Editing? 03:47 – The Woolly Mouse: Engineering Traits Across Species 07:54 – Breaking Down the Process: IVF, Screening, and Sequencing 09:24 – Mapping Genotype to Phenotype and Its Challenges 12:10 – Targeting Gene Edits: From Theory to Application in Health and Conservation 17:09 – From Hair Organoids to Building Mammoth Traits in Mice 24:41 – The Quest for a Universal Egg and Overcoming Cellular Barriers 26:17 – Artificial Wombs: The Next Frontier in Conservation and Science 31:12 – Scaling Conservation and Bridging to Human Healthcare FOLLOW BEN LAMM Twitter/X: @federallamm LinkedIn: Ben Lamm CHECK OUT OUR SPONSORS ButcherBox: Ready to level up your meals? Go to https://ButcherBox.com/impact to get $20 off your first box and FREE bacon for life with the Bilyeu Box! Vital Proteins: Get 20% off by going to https://www.vitalproteins.com and entering promo code IMPACT at check out Shopify: Sign up for your one-dollar-per-month trial period at https://shopify.com/impact Netsuite: Download the CFO's Guide to AI and Machine Learning at https://NetSuite.com/THEORY iTrust Capital: Use code IMPACTGO when you sign up and fund your account to get a $100 bonus at https://www.itrustcapital.com/tombilyeu Mint Mobile: If you like your money, Mint Mobile is for you. Shop plans at https://mintmobile.com/impact. DISCLAIMER: Upfront payment of $45 for 3-month 5 gigabyte plan required (equivalent to $15/mo.). New customer offer for first 3 months only, then full-price plan options available. Taxes & fees extra. See MINT MOBILE for details. What's up, everybody? It's Tom Bilyeu here: If you want my help... STARTING a business: join me here at ZERO TO FOUNDER SCALING a business: see if you qualify here. Get my battle-tested strategies and insights delivered weekly to your inbox: sign up here. ********************************************************************** If you're serious about leveling up your life, I urge you to check out my new podcast, Tom Bilyeu's Mindset Playbook —a goldmine of my most impactful episodes on mindset, business, and health. Trust me, your future self will thank you. ********************************************************************** LISTEN TO IMPACT THEORY AD FREE + BONUS EPISODES on APPLE PODCASTS: apple.co/impacttheory ********************************************************************** FOLLOW TOM: Instagram: https://www.instagram.com/tombilyeu/ Tik Tok: https://www.tiktok.com/@tombilyeu?lang=en Twitter: https://twitter.com/tombilyeu YouTube: https://www.youtube.com/@TomBilyeu Learn more about your ad choices. Visit megaphone.fm/adchoices
HOSTS: Miranda Reiman and Mark McCully GUESTS: Scott and Andrew Foster At Seldom Rest Farms the business model is different than many: Angus youth are their main target demographic. Selling Angus show heifers across the United States allowed brothers Scott and Bruce Foster to bring the next generation back to the Michigan farm. Today Scott's son, Andrew, and his family are active in the day-to-day management of the nationally renowned operation. Phenotype matters, but having an end product is also important. Hear how they balance it all, the reason they're so invested in the next generation of Angus enthusiasts and why they believe opening their farm gates to beef marketers makes a real difference. Scott Foster is a Niles, Mich., native and second generation Angus breeder. He and his siblings grew up on a row crop farm with a small herd of Angus show cattle, which first sparked his interest in the ring. Scott earned a degree in animal husbandry from Michigan State University, married his wife Elaine and raised their children, Andrew and Danielle, with a strong involvement in the National Junior Angus Association. Along with his brother, Bruce, Scott grew Seldom Rest Farm into a nationally recognized program, which has received many honors including 2023 Certified Angus Beef Ambassador of the Year and 2022 Master Breeder of the Year Award at the All-American Angus Breeders' Futurity show in Louisville. Andrew Foster grew up in the National Junior Angus Association, serving as vice chairman of the National Junior Angus Association Board. After earning an animal science degree from Oklahoma State University, he returned to become a partner in Seldom Rest Farms. He was honored as the 2013 Herdsman of the Year and is a well-known cattle judge across the United States. He and his wife, Emily, are raising their three daughters in the lifestyle he grew up in. SPONSOR: Deer Valley Farms invites you to their Spring Cow Sale on Saturday, May 10th, at 11 a.m. at the farm near Fayetteville, Tenn. Several of the donor females have been huge contributors to their program — see what they can do for your herd! For more information, visit https://deervalleyfarm.com/. RELATED CONTENT: Building Bonds Watch: The Foster Family, Seldom Rest Farms, 2023 Ambassador Awards Don't miss news in the Angus breed. Visit www.AngusJournal.net and subscribe to the AJ Daily e-newsletter and our monthly magazine, the Angus Journal.
Dr. Sarah Mrejen (France), Associate Professor Salomon Cohen (France), and Associate Professor Dinah Zur (Israel) explore how neovascular AMD phenotype may influence imaging choices, patient dialogue, and treatment plans. From proactive vs. conservative strategies to new anti-VEGF agents and PCV diagnosis, this expert-led discussion offers key insights into personalising care in retinal disease.
In this deeply validating episode, Julie Bjelland, LMFT, explores 25 common traits within the sensitive autistic phenotype—a presentation of autism often overlooked in women and those socialized to mask. These traits offer insight into why so many highly sensitive people are discovering, often in adulthood, that they are actually autistic. If you've felt “different” your whole life or struggled to fit into neurotypical expectations, this episode may provide the clarity and self-compassion you've been seeking.Julie discusses topics such as:Feeling out of place, misunderstood, or “not quite right”Social anxiety and communication challengesSensory sensitivities and energy crashesBurnout, masking, and the impact of misdiagnosisDeep alone-time needs and strong emotional responses to injusticeYou'll also hear more about Julie's unique approach to autism assessments, her free autism quiz, and how you can access community support and resources.Resources Mentioned:
Commentary by Dr. Justin Grodin.
In this episode, we explore Oxytocin and Vasopressin's vast roles in Human Biology. We time travel to cover the evolution of the two molecules and learn about their functions with developing and socializing. Oxytocin and Vasopressin are dynamic molecules whereby they are Peptides and Hormones. In addition, we cover previously discussed brain regions and how the molecules work alongside key Neuromodulators like Serotonin and Dopamine.Social Reward https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214365/Social Reward Requires Oxytocin and Serotonin in Nucleus Accumbens (Parvo Path) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091761/Magnocellular and Parvocellular social Information Processing https://www.cell.com/neuron/fulltext/S0896-6273(20)30770-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627320307704%3Fshowall%3DtrueMagnocellular and Parvocellular https://onlinelibrary.wiley.com/doi/10.1111/jne.12284Meta-Analysis of Intranasal https://pubmed.ncbi.nlm.nih.gov/?term=intranasal+oxytocin+autism&sort=pubdate&filter=pubt.meta-analysishttps://pubmed.ncbi.nlm.nih.gov/33400920/Intranasal Review https://pubmed.ncbi.nlm.nih.gov/38579916/(0:00) Intro; Oxytocin and Vasopressin; Episode Objectives(2:46) Oxytocin and Vasopressin; 700 million year time travel (Phylogeny)(4:12) Peptides and Hormones; Modes of Transmission- Endocrine, Paracrine, Synaptic(6:35) Proteins and Peptides; Amino Acids and Aromatic Amino Acids and Light(8:58) Magnocellular and Parvocellular(12:33) Roles of Oxytocin and Vasopressin and connections to various Brain Regions(22:20) Scientific Literatures(27:12) Oxytocin and Serotonin; 1) Reward Processing, 2) Fear Response, 3) Social-Emotional Processing(30:07) Oxytocin and Dopamine(31:08) Dopamine Receptors(31:37) GABA(33:57) Intranasal Oxytocin(36:08) Take aways from Intranasal Literature(37:24) Biggest Take Away (Magnocellular versus Parvocellular and Intranasal Administration)email: info.fromthespectrum@gmail.com
In this podcast episode, Dr. Diego Delgado discusses how to manage patients with mixed phenotype hereditary transthyretin amyloidosis over the course of their disease from initial symptoms and clinical suspicion, to monitoring patients on treatment. For additional details, please see the related video publication by Dr. Delgado and colleagues: https://www.sciencedirect.com/science/article/pii/S2589790X25001180Our Guest: Dr. Diego Delgado is the Director of the Cardiac Amyloid Centre and Associate Professor in the Division of Cardiology and Cardiac Transplantation at the University Health Network in Toronto, Ontario. Dr. Diego Delgado graduated in Medicine from the Universidad del Salvador in Buenos Aires, Argentina. He completed his Internal Medicine and Cardiology training in Hospital Espanol in Buenos Aires. Subsequently he completed a research fellowship in cardiac transplantation at Rush Presbyterian St Luke's Medical Center in Chicago, US and a research/clinical fellowship in heart failure and transplantation at the Toronto General Hospital.Dr. Delgado completed his Maters of Science in Clinical Epidemiology at the University of Toronto and the Leadership Development Program at Rotman School of Management in Toronto. He is the author of more than 100 publications in the area of heart failure, transplantation and mechanical assist devices. His interests are immunologic aspects of heart failure and transplantation and cardio oncology.This podcast episode was sponsored by AstraZeneca Canada. For other medical education content, please subscribe to our podcast or visit our website at: https://www.impactmedicom.com (https://www.impactmedicom.com/).
Dr. Hansen's lab conducted several in vitro experiments where choline chloride was supplemented to beef embryo culture media for the first seven days of embryonic development. Calves resulting from the choline-supplemented embryos were consistently 17-20 kilograms heavier at weaning. In the feeding experiment presented at the Florida Ruminant Nutrition Symposium, Dr. Sagheer fed rumen-protected choline to beef cows one day before AI through seven days post-AI, spanning ovulation, fertilization, and the first seven days of embryo development. In contrast to the in vitro studies, calves born to cows supplemented with choline during the peri-conception period were lighter at weaning than control calves. The panel discusses potential mechanisms of action for these results, including choline's role as a methyl donor potentially impacting the epigenetic programming of the embryo.
For this episode, we discuss the roles and sensitivity of mitochondria with Dr. Richard Frye, MD, PhD. Dr. Frye received an MD and a PhD in Physiology and Biophysics from Georgetown University. He is board certified in Pediatrics, Neurology with special competence in Child Neurology, and as a Certified Principal Investigator. In addition, he has a Masters in Biomedical Sciences and Biostatistics from Drexel University. Dr. Frye has over 300 publications in leading journals and book chapters.Dr. Frye shares many figures during the conversation so the listener can follow along.Dr. Richard Frye https://drfryemdphd.comRossingnol Medical Center Facebook https://www.facebook.com/RossignolMedicalCenterNeurological Health Foundation https://neurologicalhealth.orgHealthy Child Guide https://neurologicalhealth.org/the-guide-5/Daylight Computer Company https://daylightcomputer.com?sca_ref=8231379.3e0N25Wg3wuse "autism" in the discount code for $25 coupon.This is the future of tech.Chroma Light Therapy https://getchroma.co/?ref=autismuse "autism" for a 10% discount,0:00 Dr. Richard Frye0:58 Daylight Computer Company5:17 Chroma Light Devices8:27 History of Leucovorin; low risk, high reward; Folate Receptor Alpha (FRa)10:25 Blood Brain Barrier; Folate; CSF (cerebral spinal fluid)14:04 DNA, RNA; MTHFR (Methylenetetrahydrofolate reductase)17:34 Cerebral Folate deficiency; BH4, Placenta & Womb23:35 Folate deficiency & Autism26:21 Clinical Studies & Data29:28 Folate & Mitochondria; Cerebral Folate Antibodies; White Matter Findings (!)34:45 Cerebral Folate deficiency & Ranges; Autistic Phenotypes: Language, Communication, & Behaviors40:45 Language & Communication; Self-Injurious Behaviors; Hyperactivity, Agitation; Treatment duration42:53 Folate Autoantibodies & Maternal Health & Markers45:30 Studies & Behavioral outcomes; inflammation & thyroid findings46:58 Neural development; Language connections, white matter tracts & distal connections48:53 Leucovorin for different severity/levels of Autism; Spinal Bifida51:08 Preparing for pregnancy53:50 Transgenerational aspects of Folate Autoantibodies Research; Prenatal Care & Awareness59:32 Guidance & SupportX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumYT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com
Genetic innovation in animal agriculture is moving at a faster-than-ever pace, and this episode digs into the history of performance testing while exploring new technologies like computer vision, microbiome analysis and ways to collect more commercial phenotypes. The discussion covers the challenges of more data, including the labor and expense of proposing new traits, along with the opportunities to make big moves in important categories such as health and efficiency. Open-mindedness, collaboration, creativity and standardization will all be needed to make progress. What is the role of the American Angus Association and Angus Genetics Inc. in leading this change? Listen to find out. HOSTS: Miranda Reiman and Mark McCully GUESTS: John Dickinson and Troy Rowan John Dickinson is a fifth-generation Angus breeder and a former National Junior Angus Board (NJAB) chairman. A University of Illinois graduate and former regional manager for the American Angus Association, Dickinson often makes the trek between his cows in California and his home in Idaho. He is also a founding partner in Parnell Dickinson, Inc., a full-service marketing firm that works in all facets of promotion, management and cattle trade — both seedstock and commercial. Troy Rowan is an assistant professor of beef cattle genomics at the University of Tennessee– Knoxville. His research work brings together many types of “big data,” both phenotypic and genomic, to understand the genetics of economically relevant traits in beef cattle. He also has a part-time Extension appointment, making all that research applicable to the state's beef producers. Troy grew up on a small Charolais operation in Southwest Iowa and received his undergraduate degree in biology from Creighton University. He earned his doctorate in genetics from the University of Missouri before coming to Tennessee in 2021. RELATED CONTENT: Exploring Next-Generation Phenotyping that Drives Commercial Profitability Don't miss news in the Angus breed. Visit www.AngusJournal.net and subscribe to the AJ Daily e-newsletter and our monthly magazine, the Angus Journal.
Welcome back to Biohacking Beauty! Today, we're diving into the cutting-edge science of biological vs. chronological aging and how epigenetic testing is revolutionizing the way we understand skin longevity. Aging isn't just about the number of birthdays you've had—it's about how your cells are aging at the molecular level. And now, thanks to advancements in epigenetics and AI-driven diagnostics, we can measure and even influence that process.In this episode, I sit down with Hannah Went, an expert in biological age testing and the Director of Operations at TruDiagnostic, a leading epigenetics company. We explore how biological aging manifests in the skin, why epigenetic markers are more predictive of health than genetics, and how personalized interventions can actually slow or even reverse aging at the cellular level.Hannah also shares groundbreaking research on how lifestyle choices, like diet, sleep, and even skincare, can alter gene expression and influence the rate at which we age. Plus, we discuss how advanced testing methods can provide real-time feedback on how well anti-aging interventions are actually working. If you've ever wanted to take a data-driven approach to longevity, this episode is packed with insights you won't want to miss.Hannah Went is the Director of Operations at TruDiagnostic, a company at the forefront of biological age testing and longevity research. With a background in epigenetics and functional medicine, she's dedicated to helping individuals track and optimize their health using cutting-edge diagnostic tools.We Also Discuss:(00:01) Epigenetics and Biological Age Testing(13:47) Aging and Skin Link Exploration(26:13) Genetic Influence on Phenotype and Aging(31:37) Aging, Skin Health, and Lifestyle Factors(44:43) At-Home Genetic Testing SupportLearn more about:Young GooseUse code PODCAST10 to get 10% off your first purchase, and if you're a returning customer use the code PODCAST5 to get 5% off at https://www.younggoose.com/ Instagram: @young_goose_skincareHannah WentWebsite: everythingepigenetics.com Instagram: @everythingepigenetics
SummaryIn this episode of the Breeder Exchange Podcast, host Sam engages with Brent Thiel, a seasoned cattle breeder from South Dakota. Brent shares his journey from growing up on a sheep ranch to establishing Thiel Ranch, focusing on his breeding philosophy, the challenges of ranching in a remote area, and the current market trends in cattle sales. The conversation delves into the intricacies of land use on Indian reservations, the labor challenges facing the agricultural industry, and a detailed discussion on the genetics and performance of the bull LT Clarion 9054. Brent emphasizes the importance of passion in the beef industry and the opportunities it presents for the next generation.TakeawaysBrent's background in cattle breeding spans decades.Field Ranch focuses on Angus and Charolais cattle.Breeding philosophy prioritizes conformation and quality.Remote location impacts ranching operations significantly.Labor shortages are a major concern in agriculture.Market prices for cattle are at record highs.Understanding reservations is crucial for land management.Clarion 9054 is a standout bull with proven genetics.Phenotype and performance are key in breeding decisions.Passion for cattle management leads to fulfilling careers.The Breeder Exchange Podcast is produced by @breeder_genetics, an Australian bovine semen company. The podcast uncovers the story of sires within the Breeder Genetics program, and talks all things beef. Guests on the podcast include reputable individuals from successful programs globally. Follow us! Facebook: https://www.facebook.com/breederexchangeInstagram: https://www.instagram.com/breederexchange/
Researchers Identify New Phenotype and Inflammatory Responses Triggered by Oral Biofilm By Today's RDH Research Original article published on Today's RDH: https://www.todaysrdh.com/researchers-identify-new-phenotype-and-inflammatory-responses-triggered-by-oral-biofilm/ Need CE? Start earning CE credits today at https://rdh.tv/ce Get daily dental hygiene articles at https://www.todaysrdh.com Follow Today's RDH on Facebook: https://www.facebook.com/TodaysRDH/ Follow Kara RDH on Facebook: https://www.facebook.com/DentalHygieneKaraRDH/ Follow Kara RDH on Instagram: https://www.instagram.com/kara_rdh
This episode dives into the concept of the “sensitive autistic phenotype,” highlighting how many highly sensitive adults are discovering they are autistic later in life. The discussion emphasizes the need to view autism holistically, recognizing the intersection with gender, race, and other identities, and focuses on strength-based approaches and self-advocacy for better well-being. Emerging Perspective on Autism: Understanding why highly sensitive individuals may not have fit the classic autism stereotypes. Defining the Sensitive Autistic Phenotype: Emotional, sensory, and social sensitivity as core traits. Why This Matters: The importance of accurate identification for adults who've felt misunderstood, and the new approaches practitioners can take. Myths About Empathy: Correcting the misconception that autistic people lack empathy; in fact, many experience heightened empathy. Masking and Burnout: Exploring how camouflaging natural behaviors leads to exhaustion and long-term health impacts. The Double Empathy Problem: Shifting from ‘deficit' to ‘difference' in communication styles between autistic and non-autistic people. Self-Advocacy and Support: Practical tips on recognizing internal cues, using accommodations, balancing stimulation, and thriving within a society not set up for sensitive needs. Resources Mentioned in This Episode: Video Autism Assessments Global Consultations: Available via video, phone, or live text chat. Autism Resources: research, education, articles, podcast episodes, and more. Online Courses: Explore six courses designed for sensitive and neurodivergent individuals. Autism Group within the Sensitive Empowerment Community: A supportive space for connection and thriving. Julie Bjelland, LMFT A consultant and specialist in high-sensitivity and late-discovered autism. A neurodivergent psychotherapist, author, and founder of Sensitive Empowerment, Julie is passionate about guiding sensitive and neurodivergent individuals to reduce challenges, improve their mental and physical health, flourish to their fullest potential, and embrace their authentic selves. Through her global support hub, Julie provides online courses, a supportive community, a podcast, articles, and webinars—all thoughtfully designed to reduce overwhelm, balance the sensitive nervous system, and foster resilience. As a proud member of the LGBTQ+ community, Julie is devoted to creating safe, inclusive spaces where differences are celebrated and strengths are fully embraced. Discover more at JulieBjelland.com.
Obesity is one of the most pressing health challenges of our time, with genetic and molecular factors playing a crucial role in how our bodies regulate weight. In this season opener, we explore the science behind obesity, focusing on how hormones, genetics, and brain circuits influence feeding behavior and body weight. Join us for a fascinating discussion about the interplay between molecular biology and real-world health outcomes.Our guest, Dr. Giles Yeo, is a professor of molecular neuroendocrinology at the University of Cambridge and an expert in the genetics of obesity. With decades of research experience, Dr. Yeo dives into how hormones like GLP-1 interact with the brain and how genetic mutations can affect eating behaviors. He also explains the innovative molecular biology techniques his lab uses to map brain circuits and decode the genetic influences on body weight.But this episode isn't all about the lab. Dr. Yeo shares his journey from studying the genetics of Japanese pufferfish to becoming a leading voice in obesity research and science communication. Whether he's decoding how Ozempic works or reflecting on the importance of good science communication, Dr. Yeo's passion for the field—and his knack for making complex topics relatable—shines through. Subscribe to get future episodes as they drop and if you like what you're hearing we hope you'll share a review or recommend the series to a colleague. Visit the Invitrogen School of Molecular Biology to access helpful molecular biology resources and educational content, and please share this resource with anyone you know working in molecular biology. For Research Use Only. Not for use in diagnostic procedures.
The biology that gives us Autism allows us to be comfortable within ourselves.Our biology orients the Autistic towards our internal state. This is more comfortable for the Autistic in comparison to the outside world. In this episode, we cover brain regions, networks, and internal calculators. All humans use these biological calculators. However, based on the living organisms unique structure of brain regions and networks (connections), it is easy to understand why people are different.Epinephrine & Glia https://www.sciencedirect.com/science/article/pii/S009286741930621XOther Resources: Autism and Adaptive Responses https://youtu.be/Zj3_e6ZjCGkAutism and Default Mode Network https://youtu.be/9CqyH4woB34Autism and Salience Network https://youtu.be/9ZbTztb3al8Autism and B.3 https://youtu.be/Ov_Bw--zzrQ00:00 - Introduction00:42 - Biology and Autistic Comfort03:05 - Salience Network Explanation05:06 - Attention Management in Autism08:35 - Default Mode Network in Autism09:47 - Introducing Internal Calculators & Neuromodulators; Neuroplasticity10:52 - Biological Responses in Autistic Behavior14:02 - Effort and Energy: The Role of Internal Calculators; Calculator for Effort vs. Outcome17:07 - Social Interaction and Energy Use20:23 - Dopamine and Internal Calculators; Reward Prediction Error as an Internal Calculator25:18 - Internal Calculators and Societal Norms; Impact of Social Expectations on Internal Calculators; NeuroplasticityX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumYT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuATikTok: (I don't love it) https://www.tiktok.com/@fromthespectrumpodcastemail: info.fromthespectrum@gmail.com
Dr. Jesse Crayle is a clinical neuromuscular fellow in the Department of Neurology at Washington University in St. Louis and Dr. Evadnie Rampersaud is a Principal Bioinformatics Research Scientist at St. Jude Children's Research Hospital. They will be discussing their publication “Genetic Associations With an Amyotrophic Lateral Sclerosis Reversal Phenotype.”
For today's episode, we go back to the origins of Autism. It seems necessary because of the recent shifts in what is Autism and the confusion in the rates of Autism. Autism was here in the 1930's, and it magically showed up in different areas of the world. The two-part series intends to remember the phenotypes that appeared and became known as Autism and Asperger's.It is my opinion, the recent shifts in defining Autism could be rooted in questionable intentions. Regardless, one goal of the podcast is understanding and explaining Autism. By the end of the episode, and by the end of the two-part series, I hope you gain understanding of the Autistic Phenotype.If the children described by Asperger in Autistic Psychopathy in Childhood were alive today, they would receive a smorgasbord of diagnosis.Introduction to the Podcast (00:00:00 - 00:00:41,320):Asperger's Work and Concept of Autism (00:00:41,320 - 00:02:21,040):Historical Context and Asperger vs. Kanner (00:02:21,040 - 00:05:10,520):Case Study: Fritz V. (00:05:45,080 - 00:11:25,920):Detailed case study of Fritz, highlighting social integration issues, motor delays, superior speech, and behavioral challenges.Discussion on how modern medicine might label Fritz with multiple diagnoses.Case Study: Harold L. (00:13:21,040 - 00:15:25,240):Description of Harold's struggles with school, social withdrawal, and the conflict between autistic capabilities and societal expectations.Case Study: Ernest (00:17:37,960 - 00:21:00,160):Ernest's case with normal development but severe academic struggles, social withdrawal, and unique learning styles, suggesting individual teaching methods for autistics.Case Study: Hellmuth L. (00:21:16,680 - 00:24:40,240):Helmuth's case with complications at birth, delayed development, obesity, and later sexual tendencies, linking these to environmental and light exposure changes.Common Features Across Asperger's Cases (00:24:49,600 - 00:26:29,720):Summary of common traits observed across Asperger's 200 cases, including eye gaze issues, peripheral vision, and social interaction patterns.Asperger's Insights on Autistic Intelligence (00:26:29,720 - 00:27:37,760):Discussion on the unique intelligence and original ideas in autistic children, introducing the concept of "Asperger's little professors."Reflection on Autism as a Phenotype vs. Disorder (00:27:37,760 - 00:29:12,680):Historical Figures and Autism (00:29:12,680 - 00:29:41,480):Speculation on whether historical geniuses might have had autistic traits, highlighting that autism could be viewed as a superpower in certain contexts.Conclusion (00:29:41,480 - 00:30:42,800):X: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumemail: info.fromthespectrum@gmail.com
A study knocking out HIF1alpha in mice reveals a counterintuitive relationship between markers of phenotype like fat oxidation, mitochondria markers, capillary density, and fiber type, and not having improved baseline performance. This uncovers an interesting relationship between the HIF pathway and oxidative metabolism, and how seemingly opposing adaptations are complementary.
In this interview, Dave Feldman, citizen scientist and founder of the Citizen Science Foundation, and Nick Norwitz, Oxford PhD and Harvard medical student, discuss their latest study, which challenges the traditional view of LDL cholesterol and its relationship to heart disease risk and metabolic health. Their research focuses on lean mass hyper-responders (LMHRs)—lean, metabolically healthy individuals on a low-carb, high-fat diet, also known as a ketogenic diet. Their findings suggest that LDL cholesterol levels may not contribute to plaque buildup in these individuals as is commonly believed in the general population. They also delve into the role of coronary CT angiograms as a powerful tool for more accurately diagnosing heart health and evaluating cardiovascular risk. This study provides new insights into the intersection of cholesterol, heart disease, and metabolic health, offering fresh perspectives on how we should rethink diet, cholesterol management, and long-term health outcomes. Watch as they break down the intersection of cholesterol levels, heart disease, and metabolic health, offering fresh perspectives on assessing cardiovascular risk in modern medicine and calling for further research. Don't miss this enlightening discussion that could change how we view diet, cholesterol, and long-term health outcomes! *Featured In This Video* Dave Feldman X: @realDaveFeldman LinkedIn: https://www.linkedin.com/in/dave-feldman/ https://citizensciencefoundation.org/ Nick Norwitz, PhD X: @nicknorwitz https://www.linkedin.com/in/nicknorwitz/ *Related Papers* _Elevated LDL Cholesterol with a Carbohydrate-Restricted Diet: Evidence for a "Lean Mass Hyper-Responder" Phenotype_ https://pubmed.ncbi.nlm.nih.gov/35106434/ _Carbohydrate Restriction-Induced Elevations in LDL-Cholesterol and Atherosclerosis: The KETO Trial_ https://www.jacc.org/doi/10.1016/j.jacadv.2024.101109 _Carbohydrate restriction-induced elevations in LDL-cholesterol and atherosclerosis: The KETO Trial_ https://www.metabolismjournal.com/article/S0026-0495(24)00080-5/abstract *Related Videos* https://youtu.be/cXwpYDWS0RE Resources: Metabolic Mind's Families & Peers page: https://www.metabolicmind.org/families-and-peers Clinician Directory: https://www.diagnosisdiet.com/directory Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry. Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/ About us: Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them. Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications. #MetabolicMind #MetabolicNeuroscience #KetogenicMetabolicTherapy #NutritionalKetosis#AlternativeTreatment#Keto#KetogenicTherapy #MetabolicHealth#LDL#HeartHealth
Become a member of The Metabolic Initiative to access exclusive ad-free episodes and earn CMEs: https://membership.metabolicinitiative.comIn this episode of The Metabolic Link, recorded at Metabolic Health Summit 2024, we share Dr. Jeff Volek's full presentation where he takes a deep dive into the "Keto-Adapted Phenotype" with a focus on muscle. Dr. Volek, a leading expert in low-carbohydrate and ketogenic diets, shares groundbreaking research on how ketones impact muscle function and performance. Dr. Volek explores the intricate ways ketones influence muscle glycogen metabolism, ketone production in skeletal muscle, and even heart function.Dr. Volek unpacks underappreciated aspects of ketosis, such as how muscle glycogen can be preserved and replenished without the need for high carbohydrate intake, the role of ketones in cardiac health, and how skeletal muscles may play a part in ketone metabolism. This thought-provoking episode not only challenges conventional ideas about energy and performance but also offers insights for athletes, health professionals, and anyone interested in optimizing metabolic health.About Dr. VolekDr. Volek is a registered dietitian and professor in the Department of Human Sciences at The Ohio State University. For the last 25 years, he has performed translational research on how humans adapt to ketogenic diets with a dual focus on clinical and performance applications of nutritional ketosis. His scholarly work includes more than 350 peer-reviewed scientific manuscripts and five books. Dr. Volek is the Chief Science Officer and Co-Founder of Virta Health, the first clinically proven treatment to safely and sustainably reverse type 2 diabetes at scale without medications or surgery. Dr. Volek has a Bachelor of Science in dietetics from Michigan State University, and a Master of Science in exercise physiology and Doctorate in kinesiology and nutrition from Pennsylvania State University.Special Thanks to our Episode Sponsors: * Genova Connect, powered by Genova Diagnostics - Receive 15% off any of their tests with code METABOLICLINK: https://connect.gdx.net/themetaboliclink* Fatty 15 - Get 15% off their 90-day subscription Starter Kit with the code METABOLICLINK: https://fatty15.com/METABOLICLINK* Ned - Get 15% off Ned products with code METABOLICLINK at http://helloned.com/metaboliclinkIn every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!Find us on social: Instagram Facebook YouTube LinkedIn Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.
Interview with Luis R. Lopes, PhD, author of Prevalence, Cardiac Phenotype, and Outcomes of Transthyretin Variants in the UK Biobank Population, and Senthil Selvaraj, MD, MS, MA, author of Genotype- vs Phenotype-Guided Approaches to Improve ATTR Detection. Hosted by Sharlene M. Day, MD. Related Content: Prevalence, Cardiac Phenotype, and Outcomes of Transthyretin Variants in the UK Biobank Population Genotype- vs Phenotype-Guided Approaches to Improve ATTR Detection
Interview with Luis R. Lopes, PhD, author of Prevalence, Cardiac Phenotype, and Outcomes of Transthyretin Variants in the UK Biobank Population, and Senthil Selvaraj, MD, MS, MA, author of Genotype- vs Phenotype-Guided Approaches to Improve ATTR Detection. Hosted by Sharlene M. Day, MD. Related Content: Prevalence, Cardiac Phenotype, and Outcomes of Transthyretin Variants in the UK Biobank Population Genotype- vs Phenotype-Guided Approaches to Improve ATTR Detection
Michael Benatar is a Professor of Neurology and Chief of the Neuromuscular Division and Executive Director of the ALS Center at the University of Miami. Here he discusses the recent publication “The Miami Framework for ALS and related neurodegenerative disorders: an integrated view of phenotype and biology”.
Join Kenny Troiano, as he talks about the interesting world of dog. In each topic, he will go deep into the art and science of breeding dogs. Becoming a reputable breeder requires more than just a love for dogs—it demands a profound understanding of genetics, evolutionary biology, animal husbandry, and the commitment to maintaining proper breed standards. From understanding the difference between "Phenotype" and "Genotype" to having the courage required to create a true family. Learn the importance of selection and culling, where producing a large number of dogs, some being culls, is essential to uncovering the true standouts in a lineage. Discover why pedigree alone does not define a dog's worth, and why the “Name Game” should be avoided in favor of improving essential traits. He talks about the myths and truths surrounding bloodlines and hybrid vigor, and debunks common misconceptions about purity versus hybridization. Gain a greater understand of inbreeding, COI (Coefficient of Inbreeding), and the delicate balance required to maintain genetic diversity, while striving for uniformity, consistency and improvement. Whether you're a beginner breeder, dreaming of starting a new line, or a seasoned breeder aiming to refine an established one, Kenny provides invaluable insights and practical advice. He also talks about the challenges, triumphs, and dedication needed to breed and create a true family or strain. This is a show that you do not want to miss! Topics: Understand the breed Experience, as a breeder, is important, but Knowledge of breeding is required Husbandry practices - what should you know Commitment to one family Courage to do what's necessary Patience and Perseverance The importance of Selection and Culling It's important to know the difference between “Phenotype” and “Genotype.” Must be willing to produce culls to find the standouts Make sure your animals are worthy of breeding The Numbers are Necessary One animal should never represent the foundation of a whole family Avoid the Name Game - it's the peddlers playground Truth about bloodlines - purity of blood, or mongrelization? The offspring always prove the worth of the Parents Percentage Game is not real Don't breed to extremes The Offspring must be better than the parents - Or you are not improving the family. Understand that “Nothing is Perfect” Maintaining hybrid vigor is not a good thing. The Myth about hybrids and outcrosses The problem with reintroducing old blood Inbreeding and Managing the COI Performance traits and gameness are never improved in one mating or cross Consistency and uniformity is only improved or maintained through inbreeding How long does it take to create a family? Is a pedigree important? We specialize in breeding, and breeding related topics. This includes proper selection practices and the use of proven breeding programs. It is our mission to provide our followers and members a greater understanding of poultry breeding, poultry genetics, poultry health care and disease prevention, and how to improve the production and performance ability of your fowl. If you are interested in creating a strain, or improving your established strain, you are in the right place. We also want to encourage you to join us at the Breeders Academy, where we will not only help you increase your knowledge of breeding and advance your skills as a breeder, but improve the quality and performance of your fowl. If you would like to learn more, go to: https://www.breedersacademy.com #breedinggamefowl #breedingchickens #gamefowlbreeders #chickenbreeders #gamefowlbreeding #chickenbreeding, #gamefowlnation, #selectivebreeding, #poultrygenetics #poultryhealth #backyardbreeders #breedersacademy #bredtoperfection #kennytroiano #gamefowl #chickens
In this episode, we explore Oxytocin and Vasopressin's vast roles in Human Biology. We time travel to cover the evolution of the two molecules and learn about their functions with developing and socializing. Oxytocin and Vasopressin are dynamic molecules whereby they are Peptides and Hormones. In addition, we cover previously discussed brain regions and how the molecules work alongside key Neuromodulators like Serotonin and Dopamine.Social Reward https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214365/Social Reward Requires Oxytocin and Serotonin in Nucleus Accumbens (Parvo Path) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091761/Magnocellular and Parvocellular social Information Processing https://www.cell.com/neuron/fulltext/S0896-6273(20)30770-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627320307704%3Fshowall%3DtrueMagnocellular and Parvocellular https://onlinelibrary.wiley.com/doi/10.1111/jne.12284Meta-Analysis of Intranasal https://pubmed.ncbi.nlm.nih.gov/?term=intranasal+oxytocin+autism&sort=pubdate&filter=pubt.meta-analysishttps://pubmed.ncbi.nlm.nih.gov/33400920/Intranasal Review https://pubmed.ncbi.nlm.nih.gov/38579916/(0:00) Intro; Oxytocin and Vasopressin; Episode Objectives(2:46) Oxytocin and Vasopressin; 700 million year time travel (Phylogeny)(4:12) Peptides and Hormones; Modes of Transmission- Endocrine, Paracrine, Synaptic(6:35) Proteins and Peptides; Amino Acids and Aromatic Amino Acids and Light(8:58) Magnocellular and Parvocellular(12:33) Roles of Oxytocin and Vasopressin and connections to various Brain Regions(22:20) Scientific Literatures(27:12) Oxytocin and Serotonin; 1) Reward Processing, 2) Fear Response, 3) Social-Emotional Processing(30:07) Oxytocin and Dopamine(31:08) Dopamine Receptors(31:37) GABA(33:57) Intranasal Oxytocin(36:08) Take aways from Intranasal Literature(37:24) Biggest Take Away (Magnocellular versus Parvocellular and Intranasal Administration)email: info.fromthespectrum@gmail.com
Welcome to Season 6! We take a trip down to Sebastapol, CA to talk with Eleanor Kuntz & Charlotte Thomas of Leafworks! We discuss Cannabis Science, Genetics, Cultivar documenting, ID tests, Phenotype definitions, Herbarium Pressings, HLV, Pathogen testing, and more!leafworks.com
In this episode of the Grazing Grass Podcast, we delve into the rich tapestry of livestock coat color genetics. From the sleek black of Angus cattle to the lush red of Red Polls, we uncover the chromosomal dance that dictates the stunning variety of hues in our farm animals. Whether you're a livestock enthusiast or a seasoned breeder, this episode promises to deepen your appreciation for the science behind animal pigmentation. We discuss the genetic interplay of pigments, the extension and agouti loci, and the role of DNA testing in breeding for desired traits. Join us as we explore the fascinating world of color genetics and how it shapes the beauty and identity of livestock breeds. Share this journey with us to better understand the living canvas of genetics that contributes to the agricultural landscape.Visit our Sponsors:Noble Research InstituteKencove Farm Fence
A 'metabolic phenotype' is a term used to describe where your total energy expenditure (aka how many calories you burn) lies in comparison to how many calories we would predict you'd burn based on a set of equations given your height, weight, age, activity level, etc.Some people can be described as having a "thrifty" metabolic phenotype, where others may have more of a "spendthrift" phenotype. Depending on where you fall in regards to these categories, it can have an impact on how hard or easy fat loss may feel for you.In this episode I dive into the differences between both phenotypes and the implications this might have on fat loss, as well as strategies to implement to counteract the negative side effects of your category.Please leave a 5 star review if you enjoyed the podcast and be sure to join our Free Facebook Group through the link below for more exclusive content, giveaways, etc.Join Our FREE Facebook Group for more free resources, live trainings, etc:https://www.facebook.com/groups/fatlossforevergroupApply For 1 On 1 Coaching:https://form.typeform.com/to/d2FuhjbCInstagram:https://www.instagram.com/joeygast_rd/Subscribe To My Youtube Channel:https://www.youtube.com/channel/UCmg0VHE4W33iLZ-Df1fiFrgCheck Out Our Client Transformations:https://www.instagram.com/ithrivenutrition_fitness/TikTok:https://www.tiktok.com/@joeygast_rd
Not everyone with IC experiences the same condition. Symptoms vary. The way they manifest is different. Some people respond to certain medications while others don't.This led researchers to propose several different types of systems to break IC into sub-categories called ‘phenotypes'. The entire point of a phenotype is it needs to be 1) easily identifiable and 2) able to guide your treatment options.Early attempts to phenotype IC failed these criteria. There remain other proposed phenotyping systems out there but they remain unproven, and frankly unhelpful and confusing.In it's most recent IC Guidelines, the American Urological Association (AUA) simplified this into three distinct IC sub-types:Hunner's Lesions: These are patients with discernable damage (Hunner's lesions) to the bladder lining. This represents less than 10% of all people diagnosed with IC. If you've had a cystoscopy and they did not find Hunner's lesions (even if they said it was ‘a little red' or ‘angry'), you don't have this subtype. Pelvic Floor: These are people with pelvic floor dysfunction either contributing to or driving their symptoms. This is found in 85-90% of people diagnosed with IC, so is by far the most common and likely issue. Pelvic floor dysfunction can be diagnosed with a pelvic floor examination by a pelvic floor physical therapist (not necessarily your urologist or OB-GYN). Widespread Pain / Central Sensitization: This sub-type occurs when the condition has been going on long enough to cause the nervous system to go into ‘overdrive' and turn up the volume. This phenotype is characterized by symptoms of IC plus pain outside the pelvis, sensitivity to light, tough, or pressure, a history of anxiety, depression, trauma or PTSD and other associated issues. Of the phenotypes there is a lot of overlap in how they should be treated. Pelvic floor physical therapy should be recommended for all different phenotypes. Those with Hunner's lesions need to have those medically managed, and those with central sensitization need to both stop the pain signals from the pelvis (through pelvic floor physical therapy) and also work to relax the upregulated nervous system causing additional issues through the body.Remember to focus less on the label and more on finding the practitioner(s) who can help you find relief!About UsDr. Nicole and Jesse Cozean are the founders of PelvicSanity Physical Therapy (www.pelvicsanity.com) in Southern California. The clinic has helped thousands of patients in the Orange County, CA area and hundreds from around the world with a remote consultation and Out of Town Program.They co-authored The IC Solution and Nicole created The IC Roadmap online course to provide the most accurate, up-to-date information for those with interstitial cystitis. They run the Finding Pelvic Sanity Facebook group for a supportive online community for anyone dealing with pelvic health issues.Nicole has also created courses and trained thousands of pelvic PTs to provide better care through her work with Pelvic PT Rising (www.pelvicptrising.com). Subscribe to the podcast Follow @pelvicsanity for great info! Join the Finding PelvicSanity support group Check out www.pelvicsanity.com for additional help! And as always, we hope this has helped you find just a bit of pelvic sanity!
BUFFALO, NY- February 29, 2024 – A new #research paper was #published on the #cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 4, entitled, “Mapping the core senescence phenotype of primary human colon fibroblasts.” Advanced age is the largest risk factor for many diseases and several types of cancer, including colorectal cancer (CRC). Senescent cells are known to accumulate with age in various tissues, where they can modulate the surrounding tissue microenvironment through their senescence associated secretory phenotype (SASP). Recently, researchers showed that there is an increased number of senescent cells in the colons of CRC patients and demonstrated that senescent fibroblasts and their SASP create microniches in the colon that are conducive to CRC onset and progression. However, the composition of the SASP is heterogenous and cell-specific, and the precise senescence profile of colon fibroblasts has not been well-defined. In this new study, to generate a SASP atlas of human colon fibroblasts, researchers Namita Ganesh Hattangady, Kelly Carter, Brett Maroni-Rana, Ting Wang, Jessica Lee Ayers, Ming Yu, and William M. Grady from Fred Hutchinson Cancer Center and the University of Washington School of Medicine induced senescence in primary human colon fibroblasts using various in vitro methods and assessed the resulting transcriptome. “[...] we utilized various relevant stressors to induce senescence in primary cultures of colon fibroblasts and perform RNA sequencing (RNASeq) to define an atlas of stressor-specific senescent profiles and a core senescent profile that is commonly regulated by all senescence inducers.” Using RNA Sequencing and further validation by quantitative RT-PCR and Luminex assays, the team define and validate a ‘core senescent profile' that might play a significant role in shaping the colon microenvironment. They also performed KEGG analysis and GO analyses to identify key pathways and biological processes that are differentially regulated in colon fibroblast senescence. These studies provide insights into potential driver proteins involved in senescence-associated diseases, like CRC, which may lead to therapies to improve overall health in the elderly and to prevent CRC. “Further studies will be needed to address the limitations of our study and to translate our understanding of the SASP and disease into clinical care.” DOI - https://doi.org/10.18632/aging.205577 Corresponding authors - William M. Grady - wgrady@fredhutch.org, and Ming Yu - myu@fredhutch.org Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.205577 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, senescence, senescence associated secretory phenotype, SASP, colorectal cancer, cancer About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM
Episode 1298: Phenotype
Why do some people have blue eyes? What is the evolutionary advantage of having blue eyes? Where did blue eyes evolve? Blue eyes have piqued curiosity for centuries, standing out as a mesmerising and rare trait among humans. Discover the underlying science behind blue eyes as we explore various theories and genetic factors that contribute to their existence. They were mainly associated with Mesolithic Western Hunter Gatherers like Cheddar man but the origin and story of this phenotype is complicated. A new study from Liverpool may have the answer as to what benefit this trait has - better ability to see in low light.This channel depends on your support:Patreon: https://www.patreon.com/survivethejiveAll Links: https://linktr.ee/SurvivetheJiveSources:https://www.biorxiv.org/content/10.1101/2024.01.17.576074v1https://www.sciencedaily.com/releases/2008/01/080130170343.htm
Have you ever wondered why some people seem to thrive on certain diets while others struggle to find the right balance? The answer might lie in our genes. Nutrigenomics is the study of how our individual genetic makeup interacts with the food we eat, influencing everything from our metabolism to nutrient absorption to our overall well-being. In this episode we'll explore this interaction and explain how you may benefit by “eating according to your genes”. Image by Gerd AltmanShownotes: yournutritionprofs.com Do you have a nutrition question you'd like us to answer? Let us know! Contact Us on our website or any of the following ways:yournutritionprofs@gmail.comYouTubeInstagram Facebook
"The Long Reach of the Gene"
Had a great chat with JF Gariepy the other week. Follow his work below.Follow JF's work:jfg.worldhttps://odysee.com/@JFGTonight:0https://twitter.com/JFGariepyhttps://www.amazon.com/Revolutionary-Phenotype-amazing-story-begins/dp/1729861563All of my content and support links:https://linktr.ee/ignoramusmediaLivestreams over at Rumble:https://rumble.com/user/Ignoramus
Genetic Testing and Stone Disease Co-host: Kyle Wood, MD Population analysis demonstrated that genetic conditions resulting in stone disease are magnitudes higher than those seen in clinical cohorts, suggesting underdiagnosis. Urologist play a unique role as we often times have many touch points with these patient given their presentation for stone disease. With the advancement of treatments, specifically in primary hyperoxaluria, it is essential that urologist play a more active role in the earlier diagnosis of patients. Genetic testing has become readily available at lower cost and much of the perceived barriers to genetic testing are addressed by current available programs. Outline: 1. The contribution of genetics to kidney stone disease 2. Specific studies using genetic testing 3. Primary Hyperoxaluria as an example 4. Current Genetic Testing and Ease 5. The role of the Urologist References: - Hill AJ, Basourakos SP, Lewicki P, et al. Incidence of kidney stones in the United States: The Continuous National Health and Nutrition Examination Survey. J Urol. 2022;207(4):851-856. - Singh P, Harris PC, Sas DJ, Lieske JC. The genetics of kidney stone disease and nephrocalcinosis. Nat Rev Nephrol. 2022;18(4):224-240. - Goldfarb DS, Fischer ME, Keich Y, Goldberg J. A twin study of genetic and dietary influences on nephrolithiasis: a report from the Vietnam Era Twin (VET) Registry. Kidney Int. 2005;67(3):1053-1061. - Daga A, Majmundar AJ, Braun DA, et al. Whole exome sequencing frequently detects a monogenic cause in early onset nephrolithiasis and nephrocalcinosis. Kidney Int. 2018;93(1):204-213. - Braun DA, Lawson JA, Gee HY, et al. Prevalence of monogenic causes in pediatric patients with nephrolithiasis or nephrocalcinosis. Clin J Am Soc Nephrol. 2016;11(4):664-672. - Halbritter J, Baum M, Hynes AM, et al. Fourteen monogenic genes account for 15% of nephrolithiasis/nephrocalcinosis. J Am Soc Nephrol. 2015;26(3):543-551. - Knoers N, Antignac C, Bergmann C, et al. Genetic testing in the diagnosis of chronic kidney disease: recommendations for clinical practice. Nephrol Dial Transplant. 2022;37(2):239-254. - Groothoff JW, Metry E, Deesker L, et al. Clinical practice recommendations for primary hyperoxaluria: an expert consensus statement from ERKNet and OxalEurope. Nat Rev Nephrol. 2023;19(3):194-211. - van der Hoeven SM, van Woerden CS, Groothoff JW. Primary hyperoxaluria type 1, a too often missed diagnosis and potentially treatable cause of end-stage renal disease in adults: results of the Dutch cohort. Nephrol Dial Transplant. 2012;27(10):3855-3862. - Hopp K, Cogal AG, Bergstralh EJ, et al. Phenotype-genotype correlations and estimated carrier frequencies of primary hyperoxaluria. J Am Soc Nephrol. 2015;26(10):2559-2570. - Garrelfs SF, Frishberg Y, Hulton SA, et al. Lumasiran, an RNAi therapeutic for primary hyperoxaluria type 1. N Engl J Med. 2021;384(13):1216-1226. - Baum MA, Langman C, Cochat P, et al. PHYOX2: a pivotal randomized study of nedosiran in primary hyperoxaluria type 1 or 2. Kidney Int. 2023;103(1):207-217. - Soliman NA, Nabhan MM, Abdelrahman SM, et al. Clinical spectrum of primary hyperoxaluria type 1: Experience of a tertiary center. Nephrol Ther. 2017;13(3):176-182. - Schonauer R, Scherer L, Nemitz-Kliemchen M, et al. Systematic assessment of monogenic etiology in adult-onset kidney stone formers undergoing urological intervention-evidence for genetic pretest probability. Am J Med Genet C Semin Med Genet. 2022;190(3):279-288.
Guests: Dr. Pete Hansen, University of FloridaTo conclude this mini series, Dr. Pete Hansen of the University of Florida presents on the topic of using methyl donors to regulate an early embryo and create an epigenetic effect. This talk was given at the 2022 Tri-State Dairy Nutrition Conference, and is the fourth part of this series.Beginning his presentation, Dr. Hansen highlights how nutrition can cause epigenetic reprogramming of the fetus. Methyl groups can be added to increase the pattern of DNA methylation in cells and change the phenotype. 3:55To elaborate on DNA methylation, Dr. Hansen gives the example of placenta vs. embryo cells. A micrograph of both cell types shows that placenta cells have much larger amounts of methylation than embryo cells, indicating that placenta cells are specifically programmed while methylation of embryo cells can still be influenced by the environment. 4:57Continuing on the topic of methylation, Dr. Hansen discusses how DNA methylation silences specific genes, such as in skin cells or mammary glands. The methylation in the dam can be recapitulated in offspring, representing an epigenetic pattern. 14:42Opportunities to increase DNA methylation exist. Dr. Hansen points out that altering the environment of an embryo by growing it in vitro for just seven days changes the phenotype. 23:10How can this knowledge be used to the advantage of the dairy industry?Seeking to answer this question, Dr. Hansen and his graduate students added large amounts of choline (excellent source of methyl groups) to cultured embryos. They found the addition of choline to increase triglyceride accumulation and DNA methylation. 31:45After allowing the choline-treated embryos to mature in the recipient cattle, Dr. Hansen and his colleagues found the dams to have longer gestation lengths. This likely led to the higher birth weight of the calves which persisted into weaning. While a high birth weight is not particularly beneficial, a higher weaning weight certainly can be. 36:30Finishing up his presentation, Dr. Hansen refers to the common animal science equation: phenotype = genetics + environment. He praises the dairy industry's proficiency in using genetic selection to create better offspring, but he states that improvements could be made in the environment, suggesting that more focus be placed on the prenatal environment. 41:37Please subscribe and share with your industry friends to bring more people to join us around the Real Science Exchange virtual pub table. If you want one of our new Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll get a shirt in the mail to you.
With Paul Leeson & Winok Lapidaire, University of Oxford - UK Link to editorial Link to paper
Dr. Bruce Damer is a biologist, computer scientist, and director of the BIOTA Institute at UC Santa Cruz with a compelling theory for the origin of life on Earth. Damer and his colleagues have proposed that life didn't begin at the bottom of the ocean, or at a hydrothermal vent, or in the irradiated clouds of the early Earth. They propose the formation of the earliest cells out in the open, at the margins of vernal pools filled with amino acids, minerals, and proto-nucleotides rained down on Earth in the form of micrometeorites. We talk about the hardest questions on Earth, why hydrothermal vents are a dead end, why origin of life researchers don't throw hot coffee at each other any more, and how figuring out where we came from might let us keep going for long enough to reach the stars. Check out Bruce's work at the Biota Institute: https://biota.org/ (00:00:00) Go! (00:00:17) Who is Bruce Damer? (00:03:08) Why is Origins of Life Research So Contentious? (00:06:53) Picture of the Origin (00:26:36) Precursors for Life (00:41:53) Hydrothermal Vents Won't Cut It (00:52:08) Experimental Details (01:03:19) How Far on Phenotype Alone? (01:12:20) Thermodynamics of Life (01:20:07) What Drives the Reaction to Complexity? (01:26:26) Chirality Doesn't Matter? (01:30:47) Panspermia Isn't Science? Really? (01:51:23) Virus Piece of the Puzzle (02:17:27) Evaporation Cycling (02:41:15) Closing Thoughts Support the scientific revolution by joining our Patreon: https://bit.ly/3lcAasB Tell us what you think in the comments or on our Discord: https://discord.gg/MJzKT8CQub #origins #originoflife #ancient Check our short-films channel, @DemystifySci: https://www.youtube.com/c/DemystifyingScience AND our material science investigations of atomics, @MaterialAtomics https://www.youtube.com/@MaterialAtomics Join our mailing list https://bit.ly/3v3kz2S PODCAST INFO: Anastasia completed her PhD studying bioelectricity at Columbia University. When not talking to brilliant people or making movies, she spends her time painting, reading, and guiding backcountry excursions. Shilo also did his PhD at Columbia studying the elastic properties of molecular water. When he's not in the film studio, he's exploring sound in music. They are both freelance professors at various universities. - Blog: http://DemystifySci.com/blog - RSS: https://anchor.fm/s/2be66934/podcast/rss - Donate: https://bit.ly/3wkPqaD - Swag: https://bit.ly/2PXdC2y SOCIAL: - Discord: https://discord.gg/MJzKT8CQub - Facebook: https://www.facebook.com/groups/DemystifySci - Instagram: https://www.instagram.com/DemystifySci/ - Twitter: https://twitter.com/DemystifySci MUSIC: -Shilo Delay: https://g.co/kgs/oty671
Breeding Basics LIVE with Laura from Pedigrees to Puppies Host Laura Reeves takes the LIVE audience through breeding basics, reading pedigrees, health testing, phenotype vs genotype and more. This journey through the theory side of breeding, covers important topics for breeders from novice and intermediate to advanced. Use the resources of older breeders who knew the dogs and they will also be able to talk about traits that genetic testing and COA does not give you. This is an art and a science, and part of the art is finding your mentors and being able and willing to talk to a lot of different people. Not just the same people all the time. Not everybody has all the answers. One of the things that makes purebred dogs purebred is a level of inbreeding. That's what makes it purebred. Having a higher or lower level and how you use that and the healthy genes that you're doubling up on or the unhealthy genes that you're doubling up on make an enormous difference in your breeding program going forward. We have to think about the process that we intend to follow and it's ideal if you can create a plan. Is your plan to do consistent inbreeding? Maybe that's not such a great idea. Consistent line breeding? That's probably pretty safe. Consistent outcrossing is really safe from a certain perspective. In terms of health, you're not as liable to double up on a particular recessive, but at the same time, I can tell you from personal experience every single time I go out to get one thing, I get three things I did not want. So, balancing those three breeding theories is absolutely critical to your mission in your breeding program and knowing what you will consider and what you want and how you plan to get where you're going when you start. We're trying to build on this concept of “I have a stated goal. I have written it down. I have cemented it in my brain.” And I have had a very careful evaluation of the bitch that I'm working with. My foundation bitch. I know what I want to improve upon in her. I know what I will not give on, what I will give on and what is not a concern. Those are the kinds of questions that need to be addressed as you're getting started deciding if and when to breed your dog, male or female. Genotype is the pedigree that's what talks about the actual genetic involvement in each individual dog. Phenotype is what does the dog look like? When you make breeding decisions, whether you breed on a pedigree or whether you breed on dogs that look alike, no matter what their genetics are, no matter what pedigree is behind them, is, in my opinion, sort of a personal decision. I personally am a genotype freak. I am a pedigree guru. I love it. I research it. I live and die by it. And yet I know there are lots and lots and lots and lots of people out there who breed on phenotype. I want a dog that looks like this. And this is what my dog looks like I think this is what the breed looks like I want another dog that looks just like this. Hear more of this insightful, targeted conversation by listening to the entire episode above.
Mitchell Lee is the CEO and co-founder of Ora Biomedical, a Seattle-based biotech company using large-scale phenotypic drug screening in C. elegans to discover small molecule therapeutics that extend lifespan and healthspan.In this episode, Chris and Mitch discuss Ora's approach to drug discovery, which focuses on function and phenotype rather than specific targets or mechanisms. Using their proprietary "WormBot" platform, Ora screens thousands of compounds in parallel to identify molecules that impact lifespan, healthspan, and age-related disease phenotypes, allowing them to discover new longevity interventions in an unbiased, hypothesis-agnostic way.Key topics:How Ora Biomedical was founded out of a conversation between Dr. Lee and his mentor Dr. Matt Kaeberlein about spinning out a company based on the WormBot technologyWhy C. elegans is a useful model organism for discovering fundamental mechanisms of aging that can translate to mammalsHow the WormBot platform uses imaging and machine learning to measure worm lifespan, healthspan, behaviors, and response to drugs at a large scaleOra's goal of screening 1 million compounds within 3 years to find the most promising longevity interventionsStrategies for translating hits from the worm screen into rare disease therapies and direct-to-consumer natural productsThe promise of longevity interventions discovered through unbiased phenotypic screening to prevent age-related diseases and transform human healthQuotes:Quotes have been lightly edited for clarity.“What really sets us apart is that we do phenotypic screening, in live animals.""If you are finding interventions that target those fundamental drivers of aging, you expect them to have multiple different impacts on age-associated diseases. But as we test more longevity interventions, we see that they also have all kinds of different impacts on non–age-associated disease models.“It's really just taking the geroscience hypothesis seriously: If an intervention impacts aging, it's likely to have impacts across many different disease stages, even ones that we wouldn't necessarily think about as being related.”“We've seen examples of how this plays out with things like rapamycin. So it's really incredible the types of therapeutic benefits that can be had through these kinds of interventions.”"There's going to be a never before seen boom in enthusiasm, interest, engagement, and demand for longevity therapeutics. And what we're doing today is putting ourselves in the position where we're going to be able to meet that challenge in the next three to five years."Links: Email questions, comments, and feedback to podcast@bioagelabs.comTranslating Aging on Twitter: @bioagepodcastBioAge Labs Website bioagelabs.comBioAge Labs Twitter @bioagelabsBioAge Labs LinkedInOra BioMedical
Yeeerrrrr!!! What is going on everybody? This week's special guest is a distinguished senior-level executive and visionary leader, dedicated to empowering BIPOC citizens in Future Tech Industries. He is also the CEO and Founder of Black Meta Agency Corporation, Mr. Howard R. Jean, M.S. Ed. CEO ! Listen in as Rob and Howard share their experiences with spirituality, work ethic, perseverance and finding the perfect career. 2:02 -Intro of Howard R. Jean 2:45 - Impact of Claflin University & Call Me MISTER 5:20 - Process of finding yourself 6:45 Who is Howard R Jean & Sovereign Space with Jamaal 7:50 Inspiration & Power of Questioning Religion & Spirituality “Spirituality is the fuel that connects me to the past and future while i experience the present is a real and surreal way” 11:30 Privilege of having our ancestors past performance, missteps, and lessons learned 12:03 Lottery of religion and humility of being spiritual 13:13 Our moms love Alexa 14:07 Leadership origins 15:05 Power of virtual mentors to fill the voids of manhood 17:17 Wearing Suits to class at Claflin University in the Southern Heat 19:05 From Philly to SC- Street Smarts 19:52 Greatest challenges to becoming a leader 20:16 Breaking generational curses and trauma - Genotype & Phenotype - deconstructing one's self 22:32 Holistic approach to leadership and personal development 25:20 Abandonment issues with mentorship and mentoring- ways to overcome them 27:55 power of Meditation for healing 28:50 Being Haitian 29:09 privilege of having a father sets the threshold for loyalty for all men/relationships 30:09 if your mentor is not an active and involved father and loving his kids righteously then he can only give you a percentage of what he gives his kids 3131 un-healed mentors perpetuate cycles of trauma and abandonment 32:52 accountability of making missteps 3525: power of therapeutic talk and reflections - The matrix & time traveling through reflections and healing 38:00 After Claflin University and on to Troy University 40:38 the value of residential higher education experience vs a for profit education experience 44:28 the privilege of higher education 46:40 The Oprah Effect and how to leverage- Tyler Perry, Dr. Phil, and Eileen Fisher 49:09 how does the moment appreciate like an asset appreciates 50:06 Miss Winfrey - we thank you, are you listening? 52:42 Power of being a reflective practitioner and power of reflection for growth 55:35 Reflective Practitioner - meditative, regressive therapy, & continuous process improvement/reverse engineering 57:52 1,00,000 BIPOC Technologist Journey with Black Meta Agency 59:35 Growth is not linear and some answers take years to coalesce 1:00:00 The $5,000 NFT, Al Sharpton, Gary Vee, 420 Sneaker event, Pharrell, Snoop, and Lisa Leslie 1:04:20 reforming the web3 and future tech industry for workforce development with @bmaweb3 1:05:00 Black Meta Agency is blackity black and proud - bold branding 1:05:40 Started in the classroom and we're here 1:05:55 Year in review with transferable skill sets into the metaverse 1:07:30 Let's go viral!! “I'll be damned” 1:09:09 the power of FME Podcast 1:09:50 making mistakes and having no pride in servant leadership 1:10:11 why more black technologists and spiritual ascension 1:11:28 Surviving to thriving to actualizing our higher self 1:13:31 STEAM Your Dreams and Go ESTEAM Sports in Baltimore with Roman Montagueo III Connect with Howard R. Jean, M.S. Ed. CEO : Website: www.bmaweb3.com Linkedin: https://www.linkedin.com/in/howardrjean Instagram: @bmaweb3 Instagram: @howardrjean Twitter: https://twitter.com/howardrjean Youtube: https://www.youtube.com/@bmaweb3 Connect with us Here: www.fmepodcast.com Do you need or want some advice? Did you recently celebrate something important? Did you have a spicy interaction with someone? If so, we want to share your story. Submit your story for our new segment " Sharing The Experiences" here: rob@fmepodcast.com or admin@fmepodcast.com Follow us on Instagram: The show: fme_podcast Rob: komplete_vision Pass The Peaz App: passthepeazapp https://www.passthepeaz.app/ Affiliate Links: Are you seeking job seeker? Are you ready to land your next position Fast? If so, then check out resume ATM and turn your resume into ATM. https://resumeatm.com/aff/fmepodcast/ Support The Show By Shopping With Our Affiliates Check Out Garner's Garden Affiliate code Garner's Garden: Fmepodcast Music by: Romo: Support Romo' Music Jenova 7: Support Jenova 7's Music Baskaat: Support Baaskat's Music J Create: Support J Create's Music
All U.S. rice is GMO free. However the use of non-GMO DNA marker technologies has greatly improved the rice breeding process in recent years. Are these scientific breakthroughs making things easier for researchers? Are we on the path to The. Perfect. Variety? Leaders in the field from RiceTec and LSU join the podcast to talk about the technology and how they utilize it to look for specific traits in both pureline and hybrid varieties and what the future holds. With special guests: Brijesh Angira, Assistant Professor, College of Agriculture, Louisiana State University, Roberto Fritsche-Neto, Assistant Professor of Quantitative Genetics, Louisiana State University, Dr. Adam Famoso, Associate Professor, Louisiana State University, and Joshua Cobb, Director of Global Breeding Transformation, RiceTec Inc. Hosted by: Michael Klein, Steve Linscombe, and Lesley Dixon
Returning guest Jim Heffelfinger joins Robbie and the Blood Origins podcast from his perch at the Arizona Game and Fish Department to challenge the rhetoric that so-called “trophy”, i.e. selective, hunting causes phenotypical (physical) or genotypical (genetic) changes in wildlife populations. Shoutout to our Conservation Club Members! Get your trophies home safely with Safari Specialty Importers https://safarispecialtyimporters.com/services Learn more about The Wildlife Center at Legends Ranch https://www.wildlifecentermi.org/ Find properties, connect with landowners, and book an experience using Landtrust https://www.landtrust.com/ Use code ORIGINS23 to receive 10% off at huntchef.com See more from Blood Origins: https://bit.ly/BloodOrigins_Subscribe Music: Migration by Ian Post (Winter Solstice), licensed through artlist.io Podcast is brought to you by: Bushnell: https://www.bushnell.com Learn more about your ad choices. Visit megaphone.fm/adchoices
Dr. Jonathon Sullivan and Noah Hayden continue their Barbell Health podcast series, this time discussing in-depth the strength prescription for the sick aging phenotype. This episode laid out Noah's thoughts on exercise & programming criteria, and an important discussion into the role the criteria play for the coach. You can check out more of Sully's work on the Greysteel YouTube channel. Check out the Barbell Logic podcast landing page for free resources, recent offers, & more. Strength Prescription In the last podcast, Sully & Noah discussed the problems with conventional medicine and its inability to treat the sick aging phenotype. Keeping the notion of medicine, with the intent to actually address your athlete's root problems, helps frame the problem (and the solution). If force production underlies the various fitness attributes, and strength is force production, clients need to gain strength. Because strength helps all the physical attributes, barbell exercise need to be incorporated into the exercise prescription the client receives. As the client progresses, conditioning (especially HIIT) can be added, but initially, a simple, linear progression provides enough stress. Dosage Criteria for the Strength Prescription If we think about this under the concept of medicine, be start to think about dosage, the frequency of the dosage, and what exercises fall under that prescription. Barbells are good. Strength is good. How do we pick exercises. What follows is Sully and Noah discussing the traditional 4 exercise selection criteria, then Noah positing criteria for programming. Sully suggests the exercise criteria are a post hoc justification of the exercises coaches would program anyway. Certainly, for most coaches, these criteria become engrained, and rarely (if ever) are they running through these criteria to choose an exercise for their lifters. GET STARTED with one-on-one online coaching FOR FREE! Get your FIRST MONTH FREE on all strength and nutrition coaching plans. There's no contract and you can cancel anytime. Start experiencing strength now: https://bit.ly/3EJI18v Connect with the hosts Matt on Instagram Niki on Instagram Connect with the show Barbell Logic on Instagram Podcast Webpage Barbell Logic on Facebook Or email podcast@barbell-logic.com
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In a small town in the Dominican Republic, more than one percent of boys are born as ‘Güevedoces'. The name, which translates to ‘penis at twelve', refers to children who are assigned female at birth, but develop male genitalia only at the onset of puberty. This week, Hannah and Suru take a look at the fascinating science behind the phenomenon – and how it's influenced modern medicine. 2022 LIVE SHOW TICKET LINKS: https://redhandedpodcast.com Sources: https://www.telegraph.co.uk/science/2016/03/12/the-astonishing-village-where-little-girls-turn-into-boys-aged-1/ https://abcnews.go.com/Health/world-intersex-children-persons-journey-sexes/story?id=28667285 https://repository.uchastings.edu/cgi/viewcontent.cgi?article=3289&context=hastings_law_journal https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/700/556 https://www.bbc.co.uk/news/magazine-34290981 https://www.sciencealert.com/remote-town-in-the-dominican-republic-some-girls-turn-into-boys https://www.livescience.com/52247-guevedoces-girls-boys.html https://www.genome.gov/genetics-glossary/Phenotype
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