Podcasts about epidermal

Mary Mag., Patience, NO Alcohol & Drugs, Epidermal

Interview with Elizabeth J. Phillips, MD, author of Recovering From Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. Hosted by Adewole S. Adamson, MD. Related Content: Recovering From Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

Interview with Elizabeth J. Phillips, MD, author of Recovering From Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. Hosted by Adewole S. Adamson, MD. Related Content: Recovering From Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

Welcome to the emDOCs.net podcast! Join us as we review our high-yield posts from our website emDOCs.net.Today on the emDOCs cast Brit Long covers SJS/TEN. To continue to make this a worthwhile podcast for you to listen to, we appreciate any feedback and comments you may have for us. Please let us know!Subscribe to the podcast on one of the many platforms below:Apple iTunesSpotifyGoogle Play

See-through mice -Highlights from Summit Derm -Epidermal nevi and EHK -Valacyclovir + clobetasol = best for herpes labialis -Acne scarring: Classification and treatment -Want to donate to the cause? Do so here!
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What is an epidermal growth factor? How does it work? Do I need them? Are there risks of using them? Join Ella and Maggie as they dive deep (like skin deep) into the subject that is equal parts exciting and mysterious, EGFs. ASCP Esty Talk with Maggie Staszcuk and Ella Cressman Produced by Associated Skin Care Professionals (ASCP) for licensed estheticians, ASCP Esty Talk is a weekly podcast hosted by Maggie Staszcuk and Ella Cressman. We see your passion, innovation, and hard work and are here to support you by providing a platform for networking, advocacy, camaraderie, and education. We aim to inspire you to ask the right questions, find your motivation, and give you the courage to have the professional skin care career you desire. About Ella Cressman: Ella Cressman is a licensed esthetician, certified organic formulator, business owner, ingredient junkie and esthetic cheerleader! As an international educator for Lira Clinical, she enjoys empowering other estheticians and industry professionals to understand skin care from an ingredient standpoint and how that relates to the skin.   Connect with Ella Cressman:   LinkedIn: www.linkedin.com/in/ella-cressman-62aa46a    About Maggie Staszcuk: Maggie has been a licensed esthetician since 2006 and holds a bachelor's degree in business administration from Stephens College. She has worked in the spa and med-spa industry and served as an esthetics instructor and a director of education for one of the largest schools in Colorado before coming to ASCP as the Education Program Manager.     Connect with Maggie:    P 800.789.0411 EXT 1636   E MStaszcuk@ascpskincare.com or AMI@ascpskincare.com   About our Sponsors   Massage Envy is a national franchisor and does not independently own or operate any of the Massage Envy franchised locations nationwide. The Massage Envy franchise network, through its franchise locations, is the leading provider of massage services. Founded in 2002, Massage Envy now has approximately 1,100 franchise locations in 49 states that have together delivered more than 200 million massages and skin care services. Website: www.massageenvy.com/careers/career-areas/esthetician  Facebook: @MassageEnvyCareers LinkedIn: @MassageEnvy   Founded by botanical visionary Danné Montague-King, DMK is the World Leader in Paramedical Skin Revision™. Our revolutionary concept of REMOVE. REBUILD. PROTECT. MAINTAIN.® aims to match an individual's biochemistry with the appropriate skin therapy. DMK believes that the origin of most skin conditions is a result of disharmony within the skin. Using the principles of biochemistry, DMK has formulated a range of Enzymatic Treatments and Home Prescriptives that encourage the skin to return to its most balanced and healthy state. For skin care professionals whose business depends on generating long-lasting clinically-proven results, DMK's education-first approach has become essential. Hundreds of salons, spas, and even industry experts have recognized the effectiveness of the DMK concept, witnessed by thousands of people worldwide whose lives have been changed forever.   Instagram: https://www.instagram.com/dmkinternational/   TikTok: https://www.tiktok.com/@dmkinternational   Facebook: https://www.facebook.com/dmkinternational   Website: https://tizoskin.com/   At the heart of everything we do at Celluma Light Therapy, we are guided by a commitment to provide scientifically proven, evidence-based products that are FDA-cleared, shape-taking, safe, and effective. With more than 70,000 devices in clinical practice, this innovative approach to light therapy has resulted in the Celluma SERIES becoming the global leader in light therapy devices. With more than 70 product and design awards since 2015, and a product line that now includes 15 different models, which Celluma will you choose? For more information about Celluma Light Therapy, including the science behind the technology, before and after pictures, and descriptions of each device, visit www.celluma.com. For information about professional pricing, call 714-978-0080 or email info@celluma.com.     Elleebana continues to push the treatment evolution envelope and influence the global market. Company Director, Otto Mitter is a qualified Cosmetic Chemist of the Institute of Personal Care Science and award-winning global & lash brow educator. Highly passionate about product ingredients, research and development and ongoing education, Otto is the innovator for the world famous Elleebana One Shot Lash Lift system, Elleeplex ReGEN and Elleebana Brow Henna, as well as Co-Producer of the Belmacil Lash & Brow Tinting System. Otto continues to extend the boundaries of product development within the world of beauty and in collaboration with other world leaders in the industry. Website: https://elleebana-usa.com/ Facebook: https://www.facebook.com/elleebanausa Instagram: https://www.instagram.com/elleebanausa/   Oncology Spa Solutions is a leading provider of specialized training for beauty and wellness professionals, focusing on safe and compassionate care for clients with cancer. Our comprehensive courses are designed to equip estheticians, massage therapists, nail technicians, spa owners, and medical professionals with the knowledge and skills needed to provide oncology-safe treatments, manage medically reactive skin conditions, and support clients throughout their cancer journey. With a mission to educate and empower, Oncology Spa Solutions offers hands-on training, cutting-edge techniques, and in-depth understanding of product selection and protocols tailored to oncology clients. Graduates of the program become oncology-trained specialists, enjoying increased job satisfaction, client loyalty, and community connections with cancer centers and health-care providers.      Website: oncologyspasolutions.com  FB: OncologyEstheticsUS  IG: Oncology_Spa_Solutions    About Associated Skin Care Professionals (ASCP):   Associated Skin Care Professionals (ASCP) is the nation's largest association for skin care professionals and your ONLY all-inclusive source for professional liability insurance, education, community, and career support. For estheticians at every stage of the journey, ASCP is your essential partner. Get in touch with us today if you have any questions or would like to join and become an ASCP member.   Connect with ASCP:   Website: www.ascpskincare.com   Email: getconnected@ascpskincare.com   Phone: 800-789-0411   Facebook: www.facebook.com/ASCPskincare   Instagram: www.instagram.com/ascpskincare    

Teresa López-Fernández, MD, and Lova Sun, MD, MSCE discuss the key cardiotoxicities for lung cancer therapy, including radiation, epidermal growth factor receptor and immune checkpoint inhibitor therapy.

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We cover both Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN), including their definitions, causes and pathophysiology. Also includes the signs and symptoms, diagnosis and severity scoring, and treatment options. Consider subscribing on YouTube (if you found any of the info useful!): https://www.youtube.com/channel/UCRks8wB6vgz0E7buP0L_5RQ?sub_confirmation=1Patreon: https://www.patreon.com/rhesusmedicineBuy Us A Coffee!: https://www.buymeacoffee.com/rhesusmedicineTimestamps:0:00 What is Stevens-Johnson Syndrome / What is Toxic Epidermal Necrolysis? 0:37 Stevens-Johnson Syndrome Pathophysiology2:15 Stevens-Johnson Syndrome Signs and Symptoms3:23 Stevens-Johnson Syndrome Diagnosis4:39 Stevens-Johnson Syndrome TreatmentReferencesBMJ Best Practice (2022) Stevens-Johnson syndrome and toxic epidermal necrolysis. Available at https://bestpractice.bmj.com/topics/en-gb/237Julia Benedetti  MD - MSD Manual Pro (2022) Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) ****Available at https://www.msdmanuals.com/professional/dermatologic-disorders/hypersensitivity-and-reactive-skin-disorders/stevens-johnson-syndrome-sjs-and-toxic-epidermal-necrolysis-tenPlease remember this podcast and all content from Rhesus Medicine is for educational and entertainment purposes only and is not a guide to diagnose or to treat any form of condition.  The content is not to be used to guide clinical practice and is not medical advice. Please consult a healthcare professional for medical advice. 

I read from epidendrum to epigeal.     If Epidermal Growth Factor was turned into a roller coaster (look at the picture), that would be a fun ride.  https://en.wikipedia.org/wiki/Epidermal_growth_factor     The word of the episode is "epigeal". https://en.wikipedia.org/wiki/Epigeal     Theme music from Tom Maslowski https://zestysol.com/     Merchandising! https://www.teepublic.com/user/spejampar     "The Dictionary - Letter A" on YouTube   "The Dictionary - Letter B" on YouTube   "The Dictionary - Letter C" on YouTube   "The Dictionary - Letter D" on YouTube   "The Dictionary - Letter E" on YouTube     Featured in a Top 10 Dictionary Podcasts list! https://blog.feedspot.com/dictionary_podcasts/     Backwards Talking on YouTube: https://www.youtube.com/playlist?list=PLmIujMwEDbgZUexyR90jaTEEVmAYcCzuq     https://linktr.ee/spejampar dictionarypod@gmail.com https://www.facebook.com/thedictionarypod/ https://www.threads.net/@dictionarypod https://twitter.com/dictionarypod https://www.instagram.com/dictionarypod/ https://www.patreon.com/spejampar https://www.tiktok.com/@spejampar 917-727-5757

Lung cancer is a significant global health issue, being the second most commonly diagnosed cancer and the leading cause of cancer-related death worldwide. Non-small-cell lung cancer (NSCLC) represents the majority of lung cancer cases and is often diagnosed at an advanced stage. Epidermal growth factor receptor (EGFR) mutations are more common in Asian NSCLC populations than in Western populations. Activating EGFR mutations, such as exon 19 deletions and L858R, are predictive of response to tyrosine kinase inhibitors (TKIs) and have revolutionized the treatment landscape for patients with EGFR-mutated NSCLC. However, most clinical trials tend to lack data for the elderly population, even though a significant proportion of lung cancer patients are aged 65 years and older. This underrepresentation of elderly patients in clinical trials limits our understanding of the effectiveness and safety of EGFR-TKIs in this specific population. In this new study, researchers Ling-Jen Hung, Ping-Chih Hsu, Cheng-Ta Yang, Chih-Hsi Scott Kuo, John Wen-Cheng Chang, Chen-Yang Huang, Ching-Fu Chang, and Chiao-En Wu from Chang Gung University and Taoyuan General Hospital conducted a multi-institute retrospective study to investigate the effectiveness and safety of afatinib, gefitinib, and erlotinib for treatment-naïve elderly patients with EGFR-mutated advanced NSCLC. On January 8, 2024, their research paper was published in Aging's Volume 16, Issue 1, entitled, “Effectiveness and safety of afatinib, gefitinib, and erlotinib for treatment-naïve elderly patients with epidermal growth factor receptor-mutated advanced non-small-cell lung cancer: a multi-institute retrospective study.” Full blog - https://aging-us.org/2024/01/efficacy-and-safety-of-egfr-tkis-for-elderly-patients-with-nsclc/ Paper DOI - https://doi.org/10.18632/aging.205395 Corresponding author - Chiao-En Wu - 8805017@cgmh.org.tw Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.205395 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, elderly patients, epidermal growth factor receptor, tyrosine kinase inhibitor, non-small-cell lung cancer, real-world evidence About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com​​ and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

Epidermal necrolysis refers to severe cutaneous reactions that cause extensive necrosis of tissue and detachment of the epidermis. It encompasses three conditions which are on a continuum of severity and how much of the body's surface area is affected: Stevens-Johnson syndrome (SJS): Less than 10% of BSA is detached Toxic epidermal necrolysis (TEN) - More than 30% of BSA is detached SJS/TEN overlap: Between 10 and 30% of BSA is detached In this episode you'll learn:  Epidermal necrolysis pathophysiology and risk factors High risk medications that can cause SJS/TEN Complications of SJS/TEN Signs and symptoms in the prodromal and acute phase Important assessment for a patient with SJS/TEN Key tests utilized to diagnose and evaluate a patient with epidermal necrolysis Treatments for SJS/TEN, including medications Vital education components for patients and families ________ Full Transcript - Read the article and view references Factor - Support our sponsor and get 50% off ready-to-eat meals with code nursemo50 FREE CLASS - If all you've heard are nursing school horror stories, then you need this class! Join me in this on-demand session where I dispel all those nursing school myths and show you that YES...you can thrive in nursing school without it taking over your life! DIC - Learn more about disseminated intravascular coagulation in this episode! Nursing School with a Chronic Illness - Hear more from Christina Brown, RN and how she managed nursing school with a chronic illness. Study Sesh - Change the way you study with this private podcast that includes dynamic audio formats that help you review and test your recall of important nursing concepts on-the-go. Free yourself from your desk with Study Sesh!  Med Surg Solution - Are you looking for a more effective way to learn Med Surg? Enroll in Med Surg Solution and get lessons on 57 key topics and out-of-this-world study guides. LATTE Method Template - Download the free LATTE Method Template so you can streamline how you study and focus on what a nurse needs to know.

BUFFALO, NY- November 30, 2023 – A new #researchpaper was #published on the #cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 22, entitled, “Chronological aging impacts abundance, function and microRNA content of extracellular vesicles produced by human epidermal keratinocytes.” The disturbance of intercellular communication is one of the hallmarks of aging. In their new study, researchers Taku Nedachi, Christelle Bonod, Julie Rorteau, Wafae Chinoune, Yuri Ishiuchi, Sandrine Hughes, Benjamin Gillet, Nicolas Bechetoille, Dominique Sigaudo-Roussel, and Jérôme Lamartine from the University of Lyon, Toyo University and Gattefossé SAS aimed to clarify the impact of chronological aging on extracellular vesicles (EVs), a key mode of communication in mammalian tissues. “The present study was therefore conducted to elucidate whether the characteristics of EVs released from cultured human keratinocytes can be modulated during aging process.” The researchers focused on epidermal keratinocytes, the main cells of the outer protective layer of the skin which is strongly impaired in the skin of elderly. EVs were purified from conditioned medium of primary keratinocytes isolated from infant or aged adult skin. A significant increase of the relative number of EVs released from aged keratinocytes was observed whereas their size distribution was not modified. By small RNA sequencing, the researchers described a specific microRNA (miRNA) signature of aged EVs with an increase abundance of miR-30a, a key regulator of barrier function in human epidermis. EVs from aged keratinocytes were found to be able to reduce the proliferation of young keratinocytes, to impact their organogenesis properties in a reconstructed epidermis model and to slow down the early steps of skin wound healing in mice, three features observed in aged epidermis. This work reveals that intercellular communication mediated by EVs is modulated during aging process in keratinocytes and might be involved in the functional defects observed in aged skin. “To conclude, we have shown here that aging modulates EVs abundance, function and microRNA content in human keratinocytes.” DOI - https://doi.org/10.18632/aging.205245 Corresponding author - Jérôme Lamartine - jerome.lamartine@univ-lyon1.fr Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.205245 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, keratinocytes, microRNA, senescence, exosomes About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com​​ and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.28.550974v1?rss=1 Authors: Peterman, E., Quitevis, E. J. A., Goo, C. E. A., Rasmussen, J. P. Abstract: Skin is often the first physical barrier to encounter invading pathogens and physical damage. Damage to the skin must be resolved quickly and efficiently to maintain organ homeostasis. Epidermal-resident immune cells known as Langerhans cells use dendritic protrusions to dynamically surveil the skin microenvironment, which contains epithelial keratinocytes and somatosensory peripheral axons. The mechanisms governing Langerhans cell dendrite dynamics and responses to tissue damage are not well understood. Using skin explants from adult zebrafish, we show that Langerhans cells maintain normal surveillance activity following axonal degeneration and use their dynamic dendrites to engulf small axonal debris. By contrast, a ramified-to-rounded shape transition accommodates the engulfment of larger keratinocyte debris. We find that Langerhans cell dendrites are richly populated with actin and sensitive to a broad spectrum actin inhibitor. We further show that Rho-associated kinase (ROCK) inhibition leads to elongated dendrites, perturbed clearance of large debris, and reduced Langerhans cell migration to tissue-scale wounds. Altogether, our work describes the unique dynamics of Langerhans cells and involvement of the ROCK pathway in immune cell responses to damage of varying magnitude. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

This week, we're welcoming back one of the most sought after facialists in the game, Joanna Vargas! Having caught up with us live and in person fresh from her red carpet run-up, Joanna recommends the essential skin tools, ingredients and massage moves we can all use to seriously level-up our skincare routines at home. Plus, as author of the book, Glow From Within, Joanna shares her 360 approach to healthy skin from the inside out.   Mindy Kaling, Rachel Brosnahan and Maggie Gyllenhaal flock to her spas in New York and LA to experience the celebrity esthetician's skilled hands, signature “triple crown facial” and patented LED bed (yep, we said BED).  And this just in, a stand-alone atelier opens in West Hollywood later this month, with plans to open a 10,000 square foot outpost in Brooklyn this fall. Until then, listen in to hear about:   At-home facial massage moves inspired by Joanna's very own triple crown facial, and why she's not a fan of jade rollers Epidermal growth factors - found in Joanna's eponymous line of skincare, Joanna explains all of the benefits behind the buzzy ingredient The most #worthit at-home skin tools, and where to invest in pro treatments Joanna's best tips for treating puffiness – including foods to avoid Rules for getting the most effective, clear skin results, for textured, acne-prone and sensitive skin types The secret Japanese sunscreen we neeeed to protect from hyperpigmentation Joanna's personal routine, including the green smoothie she drinks for lunch every day    Pssst! If you missed Joanna's first appearance on our show, go back and listen to learn all about how to protect and fix your skin's moisture barrier. That's episode 154, January 2021.   Get social with us and let us know what you think of the episode! Find us on Instagram, Tiktok, Twitter. Join our private Facebook group, or give us a call and leave us a voicemail at 1-844-227-0302.    For any products or links mentioned in this episode, check out our website: https://breakingbeautypodcast.com/episode-recaps/ PROMO CODES Sephora Sephora has an amazing selection of Clean makeup brands and products, and the “Clean” seal makes it easy to shop. To learn more visit Sephora.com/clean   Starface If you're ready to start celebrating and decorating your pimples, you can shop the entire Starface collection at Starface.World.  And for a limited time, all Breaking Beauty listeners are getting 15% off their first purchase when you enter the code BREAKINGBEAUTY at checkout.    Blissy Blissy silk pillowcases are the best ones on the market! They have a ton of different prints and colors and they make great gifts because there's an option for literally anyone (men love them too!). Try now risk-free for 60 nights, at Blissy.com/BREAKING and get an additional 30% off.    Fast Growing Trees Join more than 1.5 million happy Fast Growing Trees customers. If you're based in the US, head to FastGrowingTrees.com/ BEAUTY now to get 15% off your entire order.  *Disclaimer: Unless otherwise stated, all products reviewed are gratis media samples submitted for editorial consideration.*   Hosts: Carlene Higgins and Jill Dunn Theme song, used with permission: Cherry Bomb by Saya
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Interview with Benjamin H. Kaffenberger, MD, MS, author of Development of a Skin-Directed Scoring System for Stevens-Johnson Syndrome and Epidermal Necrolysis: A Delphi Consensus Exercise. Hosted by Adewole S. Adamson, MD. Related Content: Development of a Skin-Directed Scoring System for Stevens-Johnson Syndrome and Epidermal Necrolysis

Interview with Benjamin H. Kaffenberger, MD, MS, author of Development of a Skin-Directed Scoring System for Stevens-Johnson Syndrome and Epidermal Necrolysis: A Delphi Consensus Exercise. Hosted by Adewole S. Adamson, MD. Related Content: Development of a Skin-Directed Scoring System for Stevens-Johnson Syndrome and Epidermal Necrolysis

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.30.534941v1?rss=1 Authors: Ingram, S., DeCorte, A., Gentry, A. E., Philpott, M. K., Moldenhauer, T., Stadler, S., Steinberg, C., Millman, J., Ehrhardt, C. J. Abstract: Analysis of DNA mixtures from sexual assault evidence is an ongoing challenge for DNA casework laboratories. There is a significant need for new techniques that can provide information as to the source of DNA, particularly for sexual assault samples that do not involve semen. The goal of this study was to develop a new biological signature system that provides additional probative value to samples comprised of mixtures of epidermal and vaginal cells, as may be observed in cases involving digital penetration. Signatures were based on morphological and autofluorescence properties of individual cells collected through Imaging Flow Cytometry (IFC). Comparisons to reference cell populations from vaginal tissue and epidermal cells collected from hands showed strong multivariate differences across greater than 80 cellular measurements. These differences were used to build a predictive framework for classifying unknown cell populations as originating from epithelial cells associated with digital penetration or epidermal tissue. As part of the classification scheme, posterior probabilities of specific tissue group membership were calculated for each cell, along with multivariate similarity to that tissue type. We tested this approach on cell populations from reference tissue as well as mock casework samples involving digital penetration. Many more cells classifying as non-epidermal tissue were detected in digital penetration samples than control hand swabbings. Minimum interpretation thresholds were developed to minimize false positives; these thresholds were also effective when screening licked hands, indicating the potential utility of this method for a variety of biological mixture types and depositional events relevant to forensic casework. Results showed that samples collected subsequent to digital penetration possessed markedly higher numbers of cells classifying as vaginal tissue as well as higher posterior probabilities for vaginal tissue ( greater than or equal to 0.90) compared to cell populations collected from hands without prior contact with vaginal tissue. Additionally, digital penetration cell populations may be resolved from saliva cell populations and other non-target tissue types. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.23.533814v1?rss=1 Authors: Scharaw, S., Sola Carvajal, A., Belevich, I., Webb, A. T., Das, S., Andersson, S., Pentinmikko, N., Villablanca, E. J., Goldenring, J. R., Jokitalo, E., Coffey, R. J., Katajisto, P. Abstract: Cell-to-cell signalling between niche and stem cells regulates tissue regeneration. While the identity of many mediating factors is known, it is largely unknown whether stem cells optimize their receptiveness to niche signals according to the niche organization. Here, we show that Lgr5+ small intestinal stem cells (ISCs) regulate the morphology and orientation of their secretory apparatus to match the niche architecture, and to increase transport efficiency of niche signal receptors. Unlike the progenitor cells lacking lateral niche contacts, ISCs orient Golgi apparatus laterally towards Paneth cells of the epithelial niche, and divide Golgi into multiple stacks reflecting the number of Paneth cell contacts. Stem cells with a higher number of lateral Golgi transported Epidermal growth factor receptor (Egfr) with a higher efficiency than cells with one Golgi. The lateral Golgi orientation and enhanced Egfr transport required A-kinase anchor protein 9 (Akap9), and was necessary for normal regenerative capacity in vitro. Moreover, reduced Akap9 in aged ISCs renders ISCs insensitive to niche-dependent modulation of Golgi stack number and transport efficiency. Our results reveal stem cell-specific Golgi complex configuration that facilitates efficient niche signal reception and tissue regeneration, which is compromised in the aged epithelium. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.23.529672v1?rss=1 Authors: Yang, Y., Yu, C., Le, Y., Gong, W., Ju, J., Zhang, G., Ji, P., Zuo, R., Liu, Z., Zhang, P., Hou, R., Fu, Y. Abstract: Proliferation and migration of epidermal stem cells (EpSCs) are essential for epithelialization during skin wound healing. Angiopoietin-like 4 (ANGPTL4) has been reported to play an important role in wound healing, but the mechanisms involved are not fully understood. Here we investigate the contribution of ANGPTL4 to full-thickness wound re-epithelialization and the underlying mechanisms using Angptl4 knockout mice. Immunohistochemical staining reveals that ANGPTL4 is significantly upregulated in the basal layer cells of the epidermis around the wound during cutaneous wound healing. ANGPTL4 deficiency impairs wound healing. H & E staining shows that ANGPTL4 deficiency significantly reduces the thickness, length and area of regenerated epidermis postwounding. Immunohistochemical staining for markers of EpSCs (alpha 6 integrin and beta 1 integrin) and cell proliferation (PCNA) shows that the number and proliferation of EpSCs in the basal layer of the epidermis are reduced in ANGPTL4-deficient mice. In vitro studies show that ANGPTL4 deficiency impedes EpSC proliferation, causes cell cycle arrest at the G1 phase and reduced the expression of cyclins D1 and A2, which can be reversed by ANGPTL4 overexpression. ANGPTL4 deletion suppresses EpSC migration, which is also rescued by ANGPTL4 overexpression. Overexpression of ANGPTL4 in EpSCs accelerates cell proliferation and migration. Collectively, our results indicate that ANGPTL4 promotes EpSCs proliferation by upregulating cyclins D1 and A2 expression and accelerating cell cycle transition from G1 to S phase, and ANGPTL4 promotes skin wound re-epithelialization by stimulating EpSC proliferation and migration. Our study reveals a novel mechanism underlying EpSC activation and re-epithelialization during cutaneous wound healing. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

In this radiology lecture, we review the ultrasound appearance of epidermal inclusion cyst! Key teaching points include: Epidermal inclusion cyst The post Case Review: Ultrasound of Epidermal Inclusion Cyst appeared first on Radiologist Headquarters.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.14.528558v1?rss=1 Authors: Clary, R. C., Jenkins, B. A., Lumpkin, E. A. Abstract: As the juncture between the body and environment, epithelia are both protective barriers and sensory interfaces that continually renew. To determine whether sensory neurons remodel to maintain homeostasis, we used in vivo two-photon imaging of somatosensory axons innervating Merkel cells in adult mouse skin. These touch receptors were highly plastic: 63% of Merkel cells and 89% of branches appeared, disappeared, grew, regressed and/or relocated over a month. Interestingly, Merkel-cell plasticity was synchronized across arbors during rapid epithelial turnover. When Merkel cells remodeled, the degree of plasticity between Merkel-cell clusters and their axons was well correlated. Moreover, branches were stabilized by Merkel-cell contacts. These findings highlight the role of epithelial-neural crosstalk in homeostatic remodeling. Conversely, axons were also dynamic when Merkel cells were stable, indicating that intrinsic neural mechanisms drive branch plasticity. Two terminal morphologies innervated Merkel cells: transient swellings called boutons, and stable cups termed kylikes. In Atoh1 knockout mice that lack Merkel cells, axons showed higher complexity than control mice, with exuberant branching and no kylikes. Thus, Merkel cells limit axonal branching and promote branch maturation. Together, these results reveal a previously unsuspected high degree of plasticity in somatosensory axons that is biased, but not solely dictated, by plasticity of target epithelial cells. This system provides a platform to identify intrinsic and extrinsic mechanisms that govern axonal patterning in epithelial homeostasis. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.13.528249v1?rss=1 Authors: Jing, J., Chen, S., Wu, X., Yang, J., Liu, X., Wang, J., Wang, J., Li, Y., Zhang, P., Tang, Z. Abstract: Intracerebral hemorrhage (ICH) is an acute cerebrovascular disease with high disability and mortality rates. Recombinant tissue plasminogen activator (rtPA) is commonly applied for hematoma evacuation in minimally invasive surgery (MIS) after ICH. However, rtPA may contact directly with brain tissue during MIS procedure, which makes it necessary to discuss the safety of rtPA. We found that, in the in vivo ICH model induced by VII-type collagenase, rtPA treatment improved the neurological function of ICH mice, alleviated the pathological damage and decreased the apoptosis and autophagy level of the peri-hematoma tissue. In the in-vitro model of ICH induced by hemin, the administration of rtPA down-regulated neuronal apoptosis, autophagy, and endoplasmic reticulum stress of neurons. Transcriptome sequencing analysis showed that rtPA treatment upregulated the PI3K/AKT/mTOR pathway in neurons, and PI3K inhibitor (LY294002) can reverse the protective effects of rtPA in inhibiting excessive apoptosis, autophagy and ER-stress. Epidermal growth factor receptor inhibitor (AG-1487) reversed the effect of rtPA on PI3K/AKT/mTOR pathway, which might indicate that the EGF domain played an important role in the activation of PI3K/AKT/mTOR pathway. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Join DMK Founder and Aesthetic Legend Danné Montague King for AMA With Danné, a podcast continuation of our regular Q&A With Danné series answering all your pressing queries on everything Skin Revision. We've got some surprises up our sleeve in this latest installment; make sure you're tuned in if you don't want to miss it! Got skincare questions? We have the answers. Submit your inquiries for the next episode via Instagram @dmkinternational or at: ask@dannemontagueking.com.New episodes every 3rd Friday of the month. Instagram - Facebook - TikTok - Twitterwww.dannemking.com

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.24.523981v1?rss=1 Authors: O'Brien, J., Niehaus, P., Remark, J., Salimian, M., Kevas, Y., Rubin, S., Kristian, T., Chandrasekeran, K., Lu, C. P.-J., Russell, J., Ho, C.-Y. Abstract: Diabetic neuropathy (DN) is a debilitating disorder characterized by mechanical allodynia and sensory loss. It has traditionally been considered a small-fiber neuropathy, defined by the loss of free nerve endings in the epidermis. Free nerve endings, however, are nociceptors which may not be the only sensor for mechanical pain. To investigate the role of mechanoreceptors, specifically Meissner corpuscles, in the development of diabetic mechanical allodynia, our study focused on the keratinocyte-secreted brain-derived neurotrophic factor (BDNF) and its transcriptional regulator sirtuin 1 (SIRT1). Wild-type DN mice demonstrated decreased SIRT1 deacetylase activity, leading to a decrease in BDNF expression and Meissner corpuscle densities in foot skin. Epidermal SIRT1 knockout (KO) mice developed exacerbated DN phenotypes including severe mechanical allodynia, markedly reduced Meissner corpuscles, and subcutaneous A-beta axon degeneration. Among the major skin-derived neurotrophic factors, only BDNF was down-regulated in epidermal SIRT1 KO mice. With similar KO phenotypes, epidermal BDNF appeared to belong to the same pathway as SIRT1 in modulating diabetic mechanical allodynia. Furthermore, mice overexpressing epidermal SIRT1 showed BDNF up-regulation and improved DN phenotypes, supporting an important role of epidermal SIRT1 and BDNF in skin sensory apparatus regeneration and functional recovery in the setting of diabetes. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.28.522133v1?rss=1 Authors: Rathod, M., Franz, H., Beyersdorfer, V., Wanuske, M.-T., Fischer, K. L., Stüdle, C., Zimmermann, A., Spindler, V. Abstract: Glycosylation is an essential mediator of cell-cell adhesion and epidermal differentiation. We used CRISPR/Cas9-based gene editing to determine the role of dolichol phosphate mannosyltransferase 1 (DPM1), a key enzyme for N- and O-glycosylation. DPM1 loss resulted in weakening of cell-cell adhesion, impaired localization of the desmosome components desmoplakin and desmoglein 2, and cytoskeletal organization defects in human keratinocytes. In a 3D organotypic human epidermis model, loss of DPM1 resulted in impaired differentiation with abnormally increased cornification, reduced thickness of non-corneal layers, and the formation of intercellular gaps in the epidermis. Using proteomic approaches, SERPINB5 was identified as novel interaction partner of desmoplakin, ameliorating the effects of DPM1 loss on cell-cell adhesion and epidermal differentiation. Further analysis showed that the changes induced by DPM1 and SERPINB5 loss were at least in part dependent on elevated TGF-{beta} signalling. Together, we identify DPM1 through SERPINB5 as a novel regulator of cell-cell adhesion and differentiation. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.06.519291v1?rss=1 Authors: Cai, Y., Zhang, X., Li, C., Ghashghaei, T., Greenbaum, A. Abstract: Tissue clearing renders entire organs transparent to enable combination with light sheet fluorescence microscopy and accelerate whole tissue imaging. Yet, challenges remain in analyzing the large resulting 3D datasets that consist of terabytes of images and information on millions of labeled cells. Previous work has established pipelines for automated analysis of tissue cleared mouse brains. However, they have focused on single color channels and/or detection of nuclear localized signals, in relatively low-resolution images. To address this gap, we present an automated workflow to map labeled neurons and astrocytes in the genetically distinct Mosaic Analysis with Double Markers (MADM) mouse forebrains. We named the workflow COMBINe (Cell detectiOn in Mouse BraIN) as it combines modules from multiple pipelines. With RetinaNet in its core, we quantitatively analyzed the regional and subregional effects of MADM-based deletion of the Epidermal growth factor receptor on neuronal and astrocyte populations in the mouse forebrain. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.31.514582v1?rss=1 Authors: Rybak, J. A., Sahoo, A. R., Kim, S., Pyron, R. J., Pitts, S. B., Guleryuz, S., Smith, A. W., Buck, M., Barrera, F. N. Abstract: The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase (RTK) commonly targeted for inhibition by anti-cancer therapeutics. Current therapeutics target the kinase domain or extracellular region of EGFR. However, these types of inhibitors are not specific for tumors over healthy tissue and therefore cause undesirable side effects. Our lab has recently developed a new strategy to regulate RTK activity by designing a peptide that specifically binds to the transmembrane (TM) region of the RTK to allosterically modify kinase activity. These peptides are acidity-responsive, allowing them to preferentially target acidic environments like tumors. We have applied this strategy to EGFR and created the PET1 peptide. We observed that PET1 behaves as a pH-responsive peptide that modulates the configuration of the EGFR TM through a direct interaction. Our data indicated that PET1 inhibits EGFR-mediated cell migration. Finally, we investigated the mechanism of inhibition through molecular dynamics simulations, which showed that PET1 sits between the EGFR TM dimer. We propose that the resulting disruption of native TM interactions disrupts the conformation of the kinase domain, inhibiting the ability of EGFR to send migratory cell signals. This study is a proof-of-concept that acidity-responsive membrane peptide ligands can be generally applied to RTKs. In addition, PET1 constitutes a viable approach to therapeutically target the TM of EGFR. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.31.514487v1?rss=1 Authors: Nedachi, T., Bonod, C., Rorteau, J., Chinoune, W., Ischiuchi, Y., Hugues, S., Gillet, B., Sigaudo-Roussel, D., Lamartine, J. Abstract: The disturbance of intercellular communication is one of the hallmarks of aging. The goal of this study is to clarify the impact of chronological aging on extracellular vesicles (EVs), a key mode of communication in mammalian tissues. We focused on epidermal keratinocytes, the main cells of the outer protective layer of the skin which is strongly impaired in the skin of elderly. EVs were purified from conditioned medium of primary keratinocytes isolated from infant or aged adult skin. A significant increase of the relative number of EVs released from aged keratinocytes was observed whereas their size distribution was not modified. By small RNA sequencing, we described a specific microRNA (miRNA) signature of aged EVs with an increase abundance of miR-30a, a key regulator of barrier function in human epidermis. EVs from aged keratinocytes were found to be able to reduce the proliferation of young keratinocytes, to impact their organogenesis properties in a reconstructed epidermis model and to slow down the early steps of skin wound healing in mice, three features observed in aged epidermis. This work reveals that intercellular communication mediated by EVs is modulated during aging process in keratinocytes and might be involved in the functional defects observed in aged skin. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Hey and welcome back to the What the Tech podcast! My name is Christopher, and in this episode Kelsey and I talk to Aditya Nittala. We had a great discussion about his work with Human Computer Interaction, and in particular, the sensors and programs that are being used right now for research on the human body. Alright! Let's see what the tech is going on. Hey listener! Thanks for tuning into this episode of the What the Tech? Podcast. Thanks again to Farhad for being our guest, Make sure to follow us on Instagram @uofc_cpsc, and leave a review wherever you listen to our podcast! Have a great day! --- Send in a voice message: https://podcasters.spotify.com/pod/show/whatthetech-ucalgary/message

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.07.511265v1?rss=1 Authors: Yoshino, J., Mali, S., Williams, C., Morita, T., Emerson, C., Arp, C., Sophie, M., Yin, C., The, L., Chikaya, H., Motoyoshi, M., Ishii, K., Emoto, K., Bautista, D. M., Parrish, J. Z. Abstract: Somatosensory neurons (SSNs) that detect and transduce mechanical, thermal, and chemical stimuli densely innervate an animal's skin. However, despite the fact that epidermal cells provide the first point of contact for sensory stimuli. our understanding of roles that epidermal cells play in SSN function, particularly nociception, remains limited. Here, we show that stimulating Drosophila epidermal cells elicits activation of SSNs including nociceptors and triggers a variety of behavior outputs, including avoidance and escape. Further, we find that epidermal cells are intrinsically mechanosensitive and that epidermal mechanically evoked calcium responses require the store-operated calcium channel Orai. Epidermal cell stimulation augments larval responses to acute nociceptive stimuli and promotes prolonged hypersensitivity to subsequent mechanical stimuli. Hence, epidermal cells are key determinants of nociceptive sensitivity and sensitization, acting as primary sensors of noxious stimuli that tune nociceptor output and drive protective behaviors. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

David Pharis, MD, FAAD interviewed by Abel Torres, MD, JD, MBA, FAAD

Infants in the NICU are patients that require specialized care with unique clinical considerations. Specific recommendations must be considered for all systems of NICU patients and the skin is not any different. Infants who are being cared for in the NICU, especially those that were born premature have an increased risk for skin trauma. On this episode, we review some of the skin care guidelines and recommendations available for clinical practice of NICU patients. As NICU clinicians, is is important to not only be aware of the anatomical variations of a term and preterm infant's skin, but to also know how that guides their clinical care and treatment plan. Many of the topics we cover on this episode have been standards of care for years, but there are also new recommendations for practice and products available based on recent research findings. NICU clinicians will hear a great review as well as up-to-date clinical recommendations for skin care of our specialized population in the NICU. The episode will also be beneficial for parents to hear the clinical practice guidelines and recommendations for term and preterm infants as well as some of the variations that may exist between different institutions. Our NICU Roadmap: A Comprehensive NICU Journal: https://empoweringnicuparents.com/nicujournal/NeoTech Free Samples: neotechneoshades.comNICU Mama Hats: https://empoweringnicuparents.com/hats/NICU Milestone Cards: https://empoweringnicuparents.com/nicuproducts/Empowering NICU Parents Show Notes: https://empoweringnicuparents.com/episode35Empowering NICU Parents Instagram: https://www.instagram.com/empoweringnicuparents/Empowering NICU Parents FB Group: https://www.facebook.com/groups/empoweringnicuparentsPinterest Page: https://pin.it/36MJjmH

You hear dermatologists mention the "multimodal approach to allergies" but what does that mean beyond prescribing an anti-itch therapy? Find out why the epidermal barrier matters and how you can help restore it for your itchy patients.

Welcome To Blue Presents A Podcast! Today my guests are Siggi and Stefan of Epidermal Veil. Join us as we discuss their debut single "My Wish Your Veil Of Flesh". We also discuss the formation of Epidermal Veil and how Stefan and Siggi met. CHECK OUT LINKSlinktr.ee/bluepresentsCHECK OUT EPIDERMAL VEIL:https://www.instagram.com/epidermalveil/https://distrokid.com/hyperfollow/epidermalveil/my-wish-your-veil-of-flesh

Suiting Ao, MD and Wang Fang, MD interviewed by Steven Chen, MD, FAAD

A Systematic Review of Efficacy and Safety of Monotherapy and Combination Therapy With Biologic for Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Kirk Barber is joined by Dr Marisa Ponzo to discuss her article in the Nov/Dec issue of the Journal of Cutaneous Medicine and Surgery, a deep and thorough investigation of treatments for Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. Dr Ponzo runs a specialty clinic that reviews these cases and is responsible for the treatment of this very rare disease, at St Paul's Hospital in Vancouver, which has become a referral centre for this condition. She's also the division head of Dermatology at St. Paul's and a community dermatologist at West Dermatology. Dr Ponzo's co-authors on this article are Dr Muskaan Sachdeva and Dr Khalad Maliyar, both from the faculty of medicine at the University of Toronto.This article is open access at the JCMS website for three weeks after this episode is posted.JCMS Author Interviews is produced by David McGuffin of Explore Podcast Productions in Ottawa.Our theme music was composed by Lee Rosevere.Be sure to also check out the CDA's Residents Podcast, Dermalogues, hosted by Dr Kerri Purdy, available at the CDA website or wherever you listen.For more on the work of the CDA, please visit our website: www.dermatology.ca

A Systematic Review of Efficacy and Safety of Monotherapy and Combination Therapy With Biologic for Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Kirk Barber is joined by Dr Marisa Ponzo to discuss her article in the Nov/Dec issue of the Journal of Cutaneous Medicine and Surgery, a deep and thorough investigation of treatments for Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. Dr Ponzo runs a specialty clinic that reviews these cases and is responsible for the treatment of this very rare disease, at St Paul's Hospital in Vancouver, which has become a referral centre for this condition. She's also the division head of Dermatology at St. Paul's and a community dermatologist at West Dermatology. Dr Ponzo's co-authors on this article are Dr Muskaan Sachdeva and Dr Khalad Maliyar, both from the faculty of medicine at the University of Toronto.This article is open access at the JCMS website for three weeks after this episode is posted.JCMS Author Interviews is produced by David McGuffin of Explore Podcast Productions in Ottawa.Our theme music was composed by Lee Rosevere.Be sure to also check out the CDA's Residents Podcast, Dermalogues, hosted by Dr Kerri Purdy, available at the CDA website or wherever you listen.For more on the work of the CDA, please visit our website: www.dermatology.ca

In the previous episode, Dr. Nagourney discussed targeted cancer therapy. One particular class of targeted agents are called epidermal growth factors. The epidermal growth factor receptor protein is involved in cell signaling pathways that control cell division and survival. Drugs that block epidermal growth factor receptor proteins can be used for certain kinds of cancer.

In this episode, we review the high-yield topic of Epidermal Inclusion Cyst from the Hand section. Follow Orthobullets on Social Media: Facebook: www.facebook.com/orthobullets Instagram: www.instagram.com/orthobulletsofficial Twitter: www.twitter.com/orthobullets LinkedIn: www.linkedin.com/company/27125689 YouTube: www.youtube.com/channel/UCMZSlD9OhkFG2t25oM14FvQ --- Send in a voice message: https://anchor.fm/orthobullets/message

This ep is all about dermaplanning and what it is!! I really hope you enjoyed this episode and I'm super happy to be back recording!! Ps. To get 50% off my course; Upgrade your Skin Science Knowledge in 10 Days, use code SLU50 & follow this link: www.skin-queen.com/skin-science-knowledge Thank you for listening and stay moisturized xx

Merhabalar, bu yazımızda sizlere acil serviste nadir de olsa karşılaştığımız Steven-Johnson sendromu (SJS) ve toksik epidermal nekrolizden (TEN) bahsedeceğim. Ufacık bir patofizyolojiden sonra SJS ve TEN ayrımından daha sonra da skorlama sistemi, mortalite oranları ve tedavi yaklaşımından bahsederek konuyu sonlandırağız. Stevens-Johnson sendromu (SJS) ve toksik epidermal nekroliz (TEN), en yaygın olarak ilaçlarla tetiklenen, ateş, yoğun nekroz ve epidermisin ayrılması ile karakterize şiddetli mukokutanöz advers reaksiyonlardır. Mukoza zarları, hastaların yüzde 90'ından fazlasında, genellikle iki veya daha fazla farklı bölgede (oküler, oral ve genital) etkilenir.1 Yaygın epidermis hasarının nedeni keratinositlerin apotozisidir. İlaçlar ya da metabolitlerinin, hapten görevi görerek keratinositlerin yüzeyine bağlanmasının ve onları antijenik hale getirmesinin olayı başlattığı düşünülmektedir. İlaca özgül CD8 (+) sitotoksik T hücrelerinin Fas/FasL ve perforin/granzim B yolağı ile keratinosit apotozisini tetikleyerek hastalığı başlattığı düşünülür.2 SJS ve TEN, bir hastalık sürekliliği olarak kabul edilir ve esas olarak, cilt dekolmanı ile ilgili vücut yüzeyinin yüzdesine dayalı olarak ayırt edilir: ●SJS, cilt dekolmanının vücut yüzeyinin yüzde 10'undan az olduğu, daha az şiddetli durumdur.  SJS Deri Değişiklikleri ●TEN, vücut yüzey alanının yüzde 30'undan fazlasının ayrılmasını içerir. Toksik Epidermal Nekroliz ●SJS/TEN örtüşmesi, vücut yüzey alanının yüzde 10 ila 30'u, cilt dekolmanı olan hastaları tanımlar. SJS/TEN örnekleri3 Şiddet ve Prognozun Hızla Değerlendirilmesi SJS ve TEN olduğundan şüphelenilen hastalar hastaneye yatırılmalıdır. SJS veya TEN tanısı konur konmaz, uygun tıbbi ortamı tanımlamak için hastalığın şiddeti ve prognozu hızla belirlenmelidir. Bireysel hastaların prognozu, SCORTEN (Score of toxic epidermal necrolysis) adı verilen prognostik skorlama sistemi kullanılarak başvuru anında hızla değerlendirilebilir.3 SCORTEN, yedi bağımsız ve kolayca ölçülebilen klinik ve laboratuvar değişkenine dayanmaktadır ve SJS/TEN için hastaneye yatışın birinci ve üçüncü günlerinde kullanım için onaylanmıştır. Parametreler SkorSkor aralığı Mortalite hızı(%)Yaş ≥ 4010-13,2Malignite1212,1Tutulan vücut yüzeyi ≥ %101335,3Taşikardi ≥1201458,3BUN >10 mmol/L ( >28 mg/dL)1≥590Serum Glukoz >14 mmol/L (>252 mg/dL) 1Serum Bikarbonat < 20 mmol/L1Skor7Stevens-Johnson Sendromu/Toksik Epidermal Nekroliz için SCORTEN Skoru11 SCORTEN skoru, aşağıda açıklanacağı gibi, her bir hastanın tedavisi için hangi klinik ortamın (yoğun tedavi/yanık ünitesi veya uzman olmayan servis) uygun olduğunu belirlemek için kullanılabilir.  Yoğun Tedaviye veya Yanık Ünitesine Sevk  Hastayı yoğun bakım veya yanık ünitesine sevk etme kararı, cilt tutulumunun kapsamına ve komorbiditelerin varlığına bağlı olarak vaka bazında verilmelidir. Hızla ilerlemeyen sınırlı cilt tutulumu olan, ve SCORTEN skoru 0 veya 1 olan hastalar, bu alanda uzmanlaşmamış servislerde tedavi edilebilir. Daha şiddetli hastalığı (cilt dekolmanı > vücut yüzey alanının % 30'u) veya SCORTEN skoru ≥2 olan hastalar, varsa yoğun bakım ünitelerine, yanık ünitelerine veya özel dermatoloji ünitelerine transfer edilmelidir. Birkaç çalışma, yanık bakım ünitesine veya yoğun bakım ünitesine hemen nakledilen hastalarda prognozun daha iyi olduğunu göstermektedir.4 Neden Olan İlaçların Hemen Kesilmesi İlaçların neden olduğu SJS ve TEN şüphesi olan hastalar için, kusurlu ajanın erken tanımlanması ve geri çekilmesi prognozu iyileştirebilir. Kesinlikle İlişkiliİlişkiliŞüpheli İlişik/Düşük RiskAllopurinolDiklofenakPantopazolLamotrijinDoksisiklinGlikokortikoidlerSülfametoksazolAmoksisilin/AmpisilinOmeprazolKarbamazepinSiprofloksasinTetrazepamFeniotinLevofloksasinDipiron (metamizol)NevirapinAmifostinTerbinafinSülfasazalinOkskarbazepinLevetirasetamDiğer SülfonamidlerRifampin (rifampisin) Oksikam NSAID'lerFenobarbitalEtorikoksibStevens-Johnson Sendromu/...

Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe skin and other body system manifestations of immune hypersensitivity, typically in response to medications and, more commonly in kids, infections. They used to be thought of as different conditions but now we think of them as occurring on a spectrum, according to how much of the body surface is affected. Toxic epidermal necrolysis is the most severe disorder in the spectrum, but both TEN and SJS can be fatal if not managed.   Links and resources: Follow us on Instagram @yourekiddingrightdoctors Facebook: https://www.facebook.com/yourekiddingrightpod-107273607638323/ Our email is yourekiddingrightpod@gmail.com Make sure you hit SUBSCRIBE/FOLLOW so you don't miss out on any pearls of wisdom and RATE if you can to help other people find us! (This isn't individual medical advice, please use your own clinical judgement and local guidelines when caring for your patients)

FDA approvals of Verzenio (abemaciclib) for adjuvant treatment of hormone receptor-positive, human epidermal growth factor receptor 2-negative, node-positive, early breast cancer, & Keytruda (pembrolizumab) for persistent, recurrent or metastatic cervical cancer whose tumors express PD-L1 (CPS ≥

Initially, I was a little thrown off when I heard Douxo® was changing their main active ingredient from phytosphingosine to ophytrium. Why change it now? But, as I learned more about the upgrades that were being made to the new Douxo® S3 line, I was really excited hear about the thought and innovation that went into upgrading this line.On this episode of the podcast, I got to talk to two amazing ladies from Ceva Animal Health: Dr. Christine Mullins (veterinary services manager) and Jacqueline Hodges (associate key account manager). They walk though the steps to this upgrade to assessing its effect on new canine skin models, a human skin model (to assure safety for owners) and in real canine patients. Not only were the ingredients considered but the user experience with the bottle, smell and lather. Enjoy learning all about this new line of topicals!

This episode covers Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN).Written notes can be found at https://zerotofinals.com/paediatrics/dermatology/sjs/ or in the dermatology section of the Zero to Finals paediatrics book.The audio in the episode was expertly edited by Harry Watchman.

Today's interview is with Lindsay Passodelis, who has a rare disease called CLOVES Syndrome (Congenital, Lipomatous, Overgrowth, Vascular malformations, Epidermal nevi, and Spinal/Skeletal anomalies and/or Scoliosis), and works at an outpatient transplant center in Pittsburgh as a social worker. She is also a blogger, an ambassador for Allstripes, and is on the CLOVES Family Advisory Council, so she basically lives to advocate! She talks about the specifics of her case, how a physical rare condition affects body image, how important support systems are in a rare disease journey, and much more! Be sure to subscribe to R is for Rare on Apple Podcasts, Spotify, or wherever you get your podcasts! Share the podcast on social media (can post from Spotify to your Instagram story), and leave a review and let me know what you think of the podcast! Follow Lindsay on Instagram - @lindsayy_lovie Lindsay's blog - peaceloveheal.org CLOVES Syndrome Community - https://clovessyndrome.org --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/annie-watson/message

Episode 3 features Dr. April Schachtel and Dr. Katherine Stiff reviewing the following recent publications:Lian et al. Spectrum of Nail Sequelae in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. JAMA Dermatol. 2021;157(1):117-119. ​Mejbel et al. Prognostic Significance of Subungual Anatomic Site in Acral Lentiginous Melanoma. Arch Pathol Lab Med 20200 [Online Head of Print].

Thomas Smith and LA Ramon presenting "The Artocracy Show" Last week we introduced the family to the Quantum Computer.  We also introduced the family to the Nano-Biological Computer. We discussed Super Positioning, Quantum Entanglement, Quantum Behavior and DNA Microchips. This week we will delve deeper into the Quantum and discuss Probablity.  PROBABILITY - LA Ramon defines it as a means to encourage people to take the risk to enforce the change necessary. Thomas (Tutmose) defines it as - the foreseeable future. We will discuss Probablity in the Quantum and Probability as it pertains to the Quantum Systems.  Also last week we explained Moore's Law and how the modern Processor Chip has reached it's smalled point. This Week will be introducing and discussing a NEW TECHNOLOGY designed to literally stretch the Processor to it's limit. This one is going to be everywhere and on everyone; EPIDERMAL TECHNOLOGY is here. It has several names depending on the intended purpose, from Electronic Tattoo's, Wearable RFID Chips, Biocompatible Flexible Electronics, E-Skin, Radio-Skin, Epidermal Electromagnetic, to Epidermal Electronics. We will explain and conversate about the MIT, Dermal Abyss Project and the top secret IEEE, Wearable Biomedical Program. This Technology will be used in and on everything and everyone.  L.A.Ramon @ELECTRONICPRODUCERS@gmail.com Thomas Smith aka Tutmose Tjs81277@gmail.com

A look at this deadly mucocutaneous reaction and how to best manage these patients in the ED https://media.blubrry.com/coreem/content.blubrry.com/coreem/SJS.mp3 Download Leave a Comment Tags: Critical Care, Dermatology Show Notes Episode Produced by Audrey Bree Tse, MD Rash with dysuria should raise concern for SJS with associated urethritis Dysuria present in a majority of cases SJS is a mucocutaneous reaction caused by Type IV hypersensitivity Cytotoxic t-lymphocytes apoptose keratinocytes → blistering, bullae formation, and sloughing of the detached skin Disease spectrum SJS = 30% TBSA SJS/ TEN Overlap = 10-30% TBSA Incidence is estimated at around 9 per 1 million people in the US Mortality is 10% for SJS and 30-50% for TEN Mainly 2/2 sepsis and end organ dysfunction. SJS can occur even without a precipitating medication Infection can set it off especially in patients with risk factors including HIV, lupus, underlying malignancy, and genetic factors SATAN for the most common drugs Sulfa, Allopurinol, Tetracyclines, Anticonvulsants, and NSAIDS Anti-epileptics include carbamazepine, lamictal, phenobarb, and phenytoin Can have a curious course Hypersensitivity reaction can develop while taking medication, or even one to four weeks after exposure In pediatric population, mycoplasma pneumonia and herpes simplex have been identified as precipitating infections Patients often have a prodrome 1-3 days prior to the skin lesions appearing May complain of fever,