Podcasts about CRH

Dr. John Sweetenham and Dr. Erika Hamilton discuss top abstracts that will be presented at the 2025 ASCO Annual Meeting, including research on tech innovations that could shape the future of oncology. Transcript Dr. John Sweetenham: Hello, and welcome to the ASCO Daily News Podcast. I'm your host, Dr. John Sweetenham, and I'm delighted to be joined today by Dr. Erika Hamilton, a medical oncologist and director of breast cancer and gynecologic cancer research at the Sarah Cannon Research Institute in Nashville, Tennessee. Dr. Hamilton is also the chair of the 2025 ASCO Annual Meeting Scientific Program, and she's here to tell us about some of the key abstracts, hot topics, and novel approaches in cancer care that will be featured at this year's Annual Meeting. Our full disclosures are available in the transcript of this episode. Dr. Hamilton, it's great to have you on the podcast today, and thanks so much for being here. Dr. Erika Hamilton: Thanks, Dr. Sweetenham. I'm glad to be here. Dr. John Sweetenham: Dr. Hamilton, the Presidential Theme of the Annual Meeting this year is ‘Driving Knowledge to Action: Building a Better Future,' and that's reflected in many of the sessions that will focus on action-oriented guidance to improve care for our patients. And as always, there'll be great presentations on practice-changing abstracts that will change treatment paradigms and transform care. Can you tell us about some of the hot topics this year and what you're particularly excited about? Dr. Erika Hamilton: You're right. Dr. Robin Zon's theme is ‘Driving Knowledge to Action: Building a Better Future,' and you're going to see that theme really interlaced throughout the ASCO program this year. We had a record number of submissions. Over 5,000 abstracts will be published, and there'll be about 3,000 presentations, either in oral format or poster presentations. We have 200 dynamic sessions. Many of the discussants will be highlighting key takeaways and how we can translate action-oriented guidance to better treat our patients to build a better future. Our state-of-the-art science will include a Plenary Session. This will feature presentations as well as discussion of each of the presentations for clinical late-breaking abstracts. We have Clinical Science Symposia that I'm particularly excited about this year. These will feature key abstracts as well as discussions and a foundational talk around the subject. We're covering novel antibody-drug conjugate targets, turning “cold” tumors “hot” to include CAR T, as well as the future of cancer detection. There'll be rapid oral abstracts, case-based panels, and this will also feature interactive audience polling and case discussions. I also want to highlight the community connection opportunities. There will be 13 Communities of Practice that will be meeting on-site during ASCO, and there's also really a plethora of networking opportunities for trainees and early-career professionals, a Women's Networking Center, a patient advocate space, and I'm happy to report there will also be live music out on the terrace this year at ASCO. Dr. John Sweetenham: Well, that's going to be a really great addition. I have to say, I think this is always a special time of year because excitement starts to mount as the meeting gets closer and closer. And once the abstracts are out there, I certainly personally feel that the excitement builds. Talking of abstracts, let's dive into some of the key abstracts for this year's meeting. I'd like to start out by asking you about Abstract 505. This reports on 15-year outcomes for women with premenopausal hormone receptor-positive early breast cancer in the SOFT and TEXT trials. It assesses the benefits of adjuvant exemestane and ovarian function suppression or tamoxifen and ovarian function suppression. So, could you talk us through this and tell us what you think the key takeaways from this abstract are? Dr. Erika Hamilton: Absolutely. This is essentially the SOFT and TEXT trials. They are trials that we've been following for quite some time, evidenced by the 15-year outcome. And I think it really answers two very important questions for us regarding adjuvant endocrine therapy for patients that are facing hormone receptor-positive disease. The benefit of ovarian function suppression for one, and then second, the benefit of exemestane over tamoxifen, which is our SERM [selective estrogen receptor modulator]. So, in terms of the SOFT trial, when we talk about distance recurrence-free interval, which I really think is probably the most meaningful because secondary cancers, et cetera, are not really what we're getting at here. But in terms of distant recurrence-free interval, certainly with tamoxifen, using tamoxifen plus ovarian function suppression adds a little bit. But where we really get additional benefits are by moving to exemestane, an aromatase inhibitor with the ovarian function suppression. So, for example, in SOFT, for distant recurrence-free interval for patients that have received prior chemotherapy, the distance recurrence-free interval was 73.5% with tamoxifen, bumped up just a tiny bit to 73.8% with ovarian function suppression. But when we used both ovarian function suppression and switched to that aromatase inhibitor, we're now talking about 77.6%. It may seem like these are small numbers, but when we talk about an absolute benefit of 4%, these are the type of decisions that we decide whether to offer chemotherapy based on. So, really just optimizing endocrine therapy really can provide additional benefits for these patients. Just briefly, when we turn to TEXT, similarly, when we look at distance recurrence-free interval for our patients that are at highest risk and receive chemotherapy, tamoxifen and ovarian function suppression, 79%; 81% with exemestane and ovarian function suppression. And when we talk about our patients that did not receive chemotherapy, it increased from 91.6% up to 94.6%—very similar that 3% to 4% number. So, I think that this is just very important information when counseling our patients about the decisions that they're going to make for themselves in the adjuvant setting and how much we want to optimize endocrine therapy. Dr. John Sweetenham: Thanks so much for your insight into that. Dr. Erika Hamilton: Yeah, absolutely. So, let's turn to hematologic malignancies. Abstract 6506 reports exciting results on the new agent ziftomenib in relapsed/refractory NPM1-mutant acute myeloid leukemia. This is a phase 1b clinical activity study and safety results. This was the pivotal KOMET-001 study. And my question is, will this new agent fulfill an unmet need in this NPM1 space? Dr. John Sweetenham: Yeah, great question. And I think the answer is almost certainly ‘yes'. So, just as some brief background, NPM1 mutation is known to be a driver of leukemogenesis in around 30% of patients with AML, and it's a poor prognostic factor. And typically, about 50% of these patients will relapse within a year of their first-line therapy, and only around 10% of them will get a subsequent complete remission with salvage therapy. Menin inhibitors, which disrupt the interaction between menin and KMT2A, are known to be active in NPM1-mutated as well as in KMT2A-rearranged AML. And ziftomenib is a selective oral menin inhibitor, which in this study was evaluated at a dose of 600 mg once a day, as you mentioned, a phase 1b/2 study, which is multicenter and presented by Dr. Eunice Wang from Roswell Park. It's a relatively large study of 112 patients who were treated with this standard dose with relatively short median follow-up at this time. The median age was 69 years, and median prior therapies were two, but with a range of one to seven. And I think very importantly, 60% of these patients had previously been treated with venetoclax, and 23% of them had had a prior transplant. Looking at the results overall for this study, the overall response rate was 35%, which is actually quite impressive. Specifically for those patients in the phase 2 part of the study, around 23% achieved a CR [complete remission] or CRh [complete remission with partial hematologic recovery]. What's very interesting in my mind is that the response rates were comparable in venetoclax-naive and venetoclax-exposed patients. And the drug was very well tolerated, with only 3% of patients having to discontinue because of treatment-related adverse events. And I think the authors appropriately conclude that, first of all, the phase 2 primary endpoint in the study was met, and that ziftomenib achieved deep and durable responses in relapsed and refractory NPM1-mutated AML, regardless of prior venetoclax, with good tolerance of the drug. And so, I think putting all of this together, undoubtedly, these data do support the potential use of this agent as monotherapy and as a new option for those patients who have relapsed or refractory NPM1-mutated acute myeloid leukemia. So, let's move on a little bit more now and change the subject and change gears completely and talk about circulating tumor DNA [ctDNA]. This has been a hot topic over a number of years now, and at this year's meeting, there are quite a few impactful studies on the use of ctDNA. We have time to focus on just one of these, and I wanted to get your thoughts on Abstract 4503. This is from the NIAGARA trial, which looks at ctDNA in patients with muscle-invasive bladder cancer who receive perioperative durvalumab. Could you tell us a little bit about this study? Dr. Erika Hamilton: So, this was the phase 3 NIAGARA trial, and this is literally looking for patients with muscle-invasive bladder cancer that are cisplatin-eligible, and the addition of durvalumab to neoadjuvant chemotherapy. So here, this is a planned exploratory analysis of ctDNA and the association with clinical outcomes from NIAGARA. So, this is really the type of study that helps us determine which of our patients are more likely to have a good outcome and which of our patients are more likely not to. There were 1,000 randomized patients in this study, and 462 comprised the biomarker-evaluable population. There were about half in the control arm and half in the durvalumab arm. And overall, the ctDNA-positive rate at baseline was about 57%, or a little over half, and that had decreased to about 22% after neoadjuvant treatment. ctDNA clearance rates from baseline to pre-radical cystectomy was about 41% among those with durvalumab and 31% among those in control. And the non-pCR rate was 97% among patients with pre-cystectomy ctDNA-positive status. So, this really gives us some information about predicting who is going to have better outcomes here. We did see a disease-free survival benefit with perioperative durvalumab, and this was observed in post-cystectomy ctDNA-positive as well as the ctDNA-negative groups. Shifting gears now to GI cancer, Abstract 3506 is a long-term safety and efficacy study of sotorasib plus panitumumab and FOLFIRI for previously treated KRAS G12C-mutated metastatic colorectal cancer. And this is the CodeBreaK-101 study. What are your thoughts on this study? Dr. John Sweetenham: Yeah, thanks. A very interesting study, and this abstract builds upon the phase 3 CodeBreaK-300 trial, which I think has just been published in the Journal of Clinical Oncology. This showed that the combination of sotorasib and panitumumab improved clinical outcomes in patients with chemorefractory KRAS G12C-mutated metastatic colorectal cancer. The current abstract, as you mentioned, reports the CodeBreaK-101 trial. And this was a phase 1b trial where FOLFIRI therapy was added to sotorasib and panitumumab in previously treated patients with KRAS G12C-mutated metastatic colorectal cancer. The abstract reports the overall and progression-free survival results, as well as some updated safety and response data. So, in this study, patients with this particular mutation who had received at least one prior systemic treatment but were KRAS G12C inhibitor-naive were enrolled into an expansion cohort of the CodeBreaK-101 protocol. And these patients received what apparently now recommended as the standard phase 2 dose of sotorasib of 960 mg daily, plus panitumumab and a standard dose of FOLFIRI. And the primary endpoint of the study was safety, and secondary endpoints included confirmed response, overall response, and progression-free survival, as assessed by the investigator. And by November of last year, 40 patients had been enrolled into this study. Common treatment-related adverse events were cutaneous; some patients developed neutropenia, and stomatitis was fairly widespread. Discontinuation of sotorasib because of adverse events was only seen in 1% of patients, although patients did have to discontinue because of toxicity from some of the other agents in the combination. Looking at the results of this study, the updated objective response rate was 57.5%, and the disease control rate was estimated at 92%, going on 93%, with a median time to response of 1.6 months and a median response duration of 6 months. After a median follow-up of 29.2 months, the median progression-free survival was 8.2 months, and the overall survival 17.9 months. So, the authors have concluded that this combination, including sotorasib, panitumumab, and FOLFIRI, does appear to show quite promising long-term efficacy in pretreated patients with this specific mutation. The ongoing phase 3 study they mentioned, CodeBreaK-301, is aiming to evaluate this combination against the standard of care in the first-line setting for patients with KRAS G12C-mutated colorectal cancer. So, promising results, and we'd be very interested to see how this particular combination performs in the frontline. Dr. Erika Hamilton: Fantastic. Thanks so much for sharing that. Let's shift gears again and really talk about digital technology. I feel that we're all going to have to get much better with this, and really, there are a lot of promises for our patients coming here. There are a lot of abstracts at ASCO that are focusing on innovations in digital technology, including a really interesting psychosocial digital application for caregivers of patients that are undergoing hematopoietic stem cell transplantation. Can you tell us a little bit about this? It's Abstract 11000. Dr. John Sweetenham: Yeah, absolutely. This abstract certainly caught my eye, and I think it's intriguing for a number of reasons, partly because it's app-based, and partly also because it specifically addresses caregiver burden and caregiver needs in the oncology setting, which I think is especially important. And although the context, the clinical context of this study, is hematopoietic stem cell transplantation, I think it has potential applications way beyond that. We all know that caregivers of patients undergoing stem cell transplantation have significant quality-of-life struggles. They are well-documented to have significant psychological and emotional strain before, during, and after stem cell transplantation. And this abstract describes an application called BMT-CARE, which is aimed at improving caregivers' quality of life, caregiver burden, mood symptoms, and coping skills, and so on. So, this was a single-center, randomized trial from MGH [Massachusetts General Hospital] of this app for stem cell transplant caregivers, compared with usual care in those individuals. And the eligible patients, or eligible individuals, were adults caring for patients with heme malignancy undergoing either an autologous or an allogeneic stem cell transplant. Patients were randomly assigned either to use the app or for usual care. And the app itself—and I think it'll be interesting to actually see this at the meeting and visualize it and see how user-friendly and so on it is—but it comprises five modules, which integrate psychoeducation, behavior change, stress management, and they're delivered through a kind of interactive platform of educational games and videos. And then participants were self-reporting at baseline and then 60 days after transplant. So, around 125 patients were enrolled in this study, of around 174 who were initially approached. So, just over 70% uptake from caregivers, which is, I think, relatively high, and evenly distributed between the two randomized arms. And the majority of the participants were spouses. And at 60 days post-stem cell transplant, the intervention participants reported a better quality of life compared with those who received usual care. If you break this down a little bit more, these participants reported lower caregiving burden, lower incidence of depression, fewer PTSD symptoms, and overall better coping skills. So, the authors conclude that this particular app, a digital health intervention, led to pretty substantial improvements in quality of life for these caregivers. So, intriguing. As I said, it'll be particularly interesting to see how this thing looks during the meeting. But if these kind of results can be reproduced, I think this sort of application has potential uses way beyond the stem cell transplant setting. Dr. Erika Hamilton: Yeah, I find that just so fascinating and very needed. I think that the caregiving role is often underestimated in how important that is for the patient and the whole family, and really giving our caregivers more tools in their toolbox certainly is quite helpful. Dr. John Sweetenham: Absolutely. Well, the meeting is getting closer, and as I mentioned earlier, I think anticipation is mounting. And I wanted to say thanks so much to you for chatting with me today about some of the interesting advances in oncology that we're going to see at this year's meeting. There is a great deal more to come. Our listeners can access links to the studies we've discussed today in the transcript of this episode. I'm also looking forward, Dr. Hamilton, to having you back on the podcast after the Annual Meeting to dive into some of the late-breaking abstracts and some of the other key science that's captured the headlines this year. So, thanks once again for joining me today. Dr. Erika Hamilton: Thanks so much for having me. Pleasure. Dr. John Sweetenham: And thank you to our listeners for joining us today. Be sure to catch my “Top Takeaways from ASCO25.” These are short episodes that will drop each day of the meeting at 5:30 p.m. Eastern Time. So, subscribe to the ASCO Daily News Podcast wherever you prefer to listen, and join me for concise analyses of the meeting's key abstracts.   Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.   More on today's speakers: Dr. John Sweetenham   Dr. Erika Hamilton @erikahamilton9   Follow ASCO on social media:  @ASCO on Twitter  ASCO on Bluesky  ASCO on Facebook   ASCO on LinkedIn     Disclosures:     Dr. John Sweetenham:     No relationships to disclose  Dr. Erika Hamilton: Consulting or Advisory Role (Inst): Pfizer, Genentech/Roche, Lilly, Daiichi Sankyo, Mersana, AstraZeneca, Novartis, Ellipses Pharma, Olema Pharmaceuticals, Stemline Therapeutics, Tubulis, Verascity Science, Theratechnologies, Accutar Biotechnology, Entos, Fosun Pharma, Gilead Sciences, Jazz Pharmaceuticals, Medical Pharma Services, Hosun Pharma, Zentalis Pharmaceuticals, Jefferies, Tempus Labs, Arvinas, Circle Pharma, Janssen, Johnson and Johnson   Research Funding (Inst): AstraZeneca, Hutchison MediPharma, OncoMed, MedImmune, Stem CentRx, Genentech/Roche, Curis, Verastem, Zymeworks, Syndax, Lycera, Rgenix, Novartis, Millenium, TapImmune, Inc., Lilly, Pfizer, Lilly, Pfizer, Tesaro, Boehringer Ingelheim, H3 Biomedicine, Radius Health, Acerta Pharma, Macrogenics, Abbvie, Immunomedics, Fujifilm, eFFECTOR Therapeutics, Merus, Nucana, Regeneron, Leap Therapeutics, Taiho Pharmaceuticals, EMD Serono, Daiichi Sankyo, ArQule, Syros Pharmaceuticals, Clovis Oncology, CytomX Therapeutics, InventisBio, Deciphera, Sermonix Pharmaceuticals, Zenith Epigentics, Arvinas, Harpoon, Black Diamond, Orinove, Molecular Templates, Seattle Genetics, Compugen, GI Therapeutics, Karyopharm Therapeutics, Dana-Farber Cancer Hospital, Shattuck Labs, PharmaMar, Olema Pharmaceuticals, Immunogen, Plexxikon, Amgen, Akesobio Australia, ADC Therapeutics, AtlasMedx, Aravive, Ellipses Pharma, Incyte, MabSpace Biosciences, ORIC Pharmaceuticals, Pieris Pharmaceuticals, Pieris Pharmaceuticals, Pionyr, Repetoire Immune Medicines, Treadwell Therapeutics, Accutar Biotech, Artios, Bliss Biopharmaceutical, Cascadian Therapeutics, Dantari, Duality Biologics, Elucida Oncology, Infinity Pharmaceuticals, Relay Therapeutics, Tolmar, Torque, BeiGene, Context Therapeutics, K-Group Beta, Kind Pharmaceuticals, Loxo Oncology, Oncothyreon, Orum Therapeutics, Prelude Therapeutics, Profound Bio, Cullinan Oncology, Bristol-Myers Squib, Eisai, Fochon Pharmaceuticals, Gilead Sciences, Inspirna, Myriad Genetics, Silverback Therapeutics, Stemline Therapeutics

In der heutigen Folge von „Alles auf Aktien“ sprechen die Finanzjournalisten Anja Ettel und Holger Zschäpitz über haussierende Börsen, gute Nachrichten von Adidas und die Chancen auf Waffenstillstand in der Ukraine. Außerdem geht es um Adidas, Delivery Hero, Apple, Meta, Amazon, Tesla, Enphase, Chipotle, Goldpreis, SK Hynix, IBM, Newmont, ServiceNow, Siemens, ABB, Prysmian, NKT, CRH, Heidelberg Materials, Wienerberger, Holcim, Konecranes, Kion Akzo Nobel, Air Liquide, BASF, Evonik, Ferrexpo, Kernel, Pekao, PKO Bank, Raiffeisen, Wizz Air, Easyjet, Ryanair, Expat Poland WIG20 ETF (WKN: A2JAHA), MSCI All Country World etwa den SPDR MSCI ACWI ETF (WKN: A1JJTC), Vanguard FTSE All World ETF (WKN: A2PKXG) und Alphabet. Wir freuen uns an Feedback über aaa@welt.de. Ab sofort gibt es noch mehr "Alles auf Aktien" bei WELTplus und Apple Podcasts – inklusive aller Artikel der Hosts und AAA-Newsletter.[ Hier bei WELT.](https://www.welt.de/podcasts/alles-auf-aktien/plus247399208/Boersen-Podcast-AAA-Bonus-Folgen-Jede-Woche-noch-mehr-Antworten-auf-Eure-Boersen-Fragen.html) [Hier] (https://open.spotify.com/playlist/6zxjyJpTMunyYCY6F7vHK1?si=8f6cTnkEQnmSrlMU8Vo6uQ) findest Du die Samstagsfolgen Klassiker-Playlist auf Spotify! Disclaimer: Die im Podcast besprochenen Aktien und Fonds stellen keine spezifischen Kauf- oder Anlage-Empfehlungen dar. Die Moderatoren und der Verlag haften nicht für etwaige Verluste, die aufgrund der Umsetzung der Gedanken oder Ideen entstehen. Hörtipps: Für alle, die noch mehr wissen wollen: Holger Zschäpitz können Sie jede Woche im Finanz- und Wirtschaftspodcast "Deffner&Zschäpitz" hören. Außerdem bei WELT: Im werktäglichen Podcast „Das bringt der Tag“ geben wir Ihnen im Gespräch mit WELT-Experten die wichtigsten Hintergrundinformationen zu einem politischen Top-Thema des Tages. +++ Werbung +++ Du möchtest mehr über unsere Werbepartner erfahren? [**Hier findest du alle Infos & Rabatte!**](https://linktr.ee/alles_auf_aktien) Impressum: https://www.welt.de/services/article7893735/Impressum.html Datenschutz: https://www.welt.de/services/article157550705/Datenschutzerklaerung-WELT-DIGITAL.html

In today's episode, we detail the enteric nervous system and regulation of gastrointestinal motility. We discuss factors including dysautonomia, stress, microbial overgrowth, and more, with regards to potential effects upon gastrointestinal motility. We further detail symptoms of altered GI motility. Topics:1. Introduction to Gastrointestinal Motility- Orchestrated contraction of smooth muscles that propel contents along the digestive tract.  - Roles in mixing, absorption, and preventing bacterial overgrowth.- Disruptions in motility. 2. The Enteric Nervous System (ENS) and Its Role- Myenteric and submucosal plexus.- Coordinating contractions and relaxations for effective motility. - Mucosa includes epithelium, lamina propria, and muscle.  - Submucosa houses the submucosal plexus.  - Muscularis externa. - Inner circular and outer longitudinal muscle layers with the myenteric plexus in between.   3. The Role of Interstitial Cells of Cajal (ICCs)- Specialized pacemaker cells in muscular layers  - Generate slow-wave electrical activity to synchronize smooth muscle contractions  - Critical for peristalsis.- Work with neural inputs to fine-tune gut motility   4. Dysautonomia and Its Impact on Gut Motility- Dysfunction of the autonomic nervous system (ANS)  - Motility impacts- Microbial overgrowth, SIBO 5. Gastrointestinal Dysmotility- Neurological dysregulation - Structural abnormalities and smooth muscle dysfunction  - Hormonal imbalances - Microbial overgrowth - Autoimmunity  6. The HPA Axis- Hypothalamus, pituitary gland, adrenal glands  - Central to the stress response and interlinked with gut function  - The amygdala and PVN of the hypothalamus  - CRH stimulates ACTH, leading to cortisol release from adrenal glands   7. Cortisol and Gut Barrier Function- Cortisol is a glucocorticoid that modulates immune function and gut physiology  - Chronic cortisol exposure can impair tight junction (TJ) integrity  - Increases paracellular permeability and allows passage of antigens and endotoxins   8.Stress-Induced Changes in Gut Motility- Slow gastric motility - Increased colonic motility  9. Symptoms of GI Dysmotility10. Addressing Root Cause(s)Thank you to our episode sponsor:1. Shop ⁠⁠⁠⁠⁠⁠⁠Fresh Press Farms⁠⁠⁠'⁠⁠⁠⁠⁠⁠⁠⁠Peach Cider Vinegar⁠⁠⁠⁠ at Sprouts locations nationwide, and check out their full collection ⁠⁠⁠⁠⁠⁠⁠here⁠⁠⁠⁠⁠⁠⁠. Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

In this episode, we detail the bidirectional relationship between the HPA axis and the intestinal barrier, illustrating how HPA axis dysfunction and cortisol dysregulation can impact intestinal permeability. We further discuss how intestinal dysbiosis can contribute to HPA axis overstimulation. Lastly, we detail some of the roles of short-chain fatty acids (SCFAs) and secretory IgA (sIgA) in this bidirectional relationship.Topics: 1. Overview of the HPA Axis and Gut Bidirectional Relationship- Chronic HPA activation, intestinal permeability, mucosalimmunity, and microbiome composition.   2. Components and Function of the HPA Axis- Hypothalamus, pituitary gland, and adrenal glands.  - Stress signals from the amygdala and prefrontal cortex, CRH release from the hypothalamus.  - CRH stimulates ACTH release from the pituitary.- Cortisol production and release. 3. Structure of the Intestinal Epithelial Barrier- The gut barrier consists of the intestinal lumen, microbiome, mucus layer, epithelial cells, and lamina propria.  - Specialized epithelial cells: goblet cells, enterocytes, enteroendocrine cells, and more.- The lamina propria contains immune cells, blood vessels, and lymphatics, supported by a smooth muscle layer.   4. Intestinal Permeability and Tight Junction Regulation- Transport across the intestinal epithelium: transcellular and paracellular pathways.  - Nutrient absorption and selective permeability.  - Tight junction proteins, such as occludin and claudins.   5. Cortisol's Impact on Gut Barrier Integrity- Cortisol can cross the intestinal microvascular endothelium and enter the lamina propria. - Chronic cortisol exposure and intestinal barrier function.- Increased permeability allows luminal antigens and bacterial endotoxins (e.g., LPS) to infiltrate the lamina propria.   6. Secretory IgA (sIgA) and Gut Immune Function  - Chronic cortisol exposure can reduce sIgA levels, weakening mucosal immunity.  - sIgA neutralizes pathogens, prevents microbial adhesion, and more.  - Lower sIgA levels increase susceptibility to dysbiosis and infections.   7. CRH and Its Role in Intestinal Permeability- CRH is produced in the hypothalamus and also peripherally.- CRH can stimulate mast cells, triggering histamine and inflammatory mediator release.  - Mast cell activation can increase gut permeability. 8. Microbiome's Influence on HPA Axis Regulation- Dysbiosis can disrupt HPA axis function.- IBS and sustained HPA activation.- Dysbiosis reduces SCFA production.  - SCFAs, particularly butyrate, support colonocyte health, tight junction integrity, and anti-inflammatory pathways.  - Inflammation and HPA axis dysfunction. 9. Root Cause Approach & Closing- Chronic cortisol exposure, CRH signaling, and gut barrier dysfunction.  - The microbiome influences stress response and HPA axis activity.  - Roles of SCFAs, sIgA, and tight junction proteins.- Addressing gut dysbiosis and GI-derived inflammation can support HPA axis regulation.  - Root cause approach.Thank you to our episode sponsors:1. Shop ⁠⁠⁠Fresh Press Farms⁠⁠⁠'Peach Cider Vinegar at Sprouts locations nationwide, and check out their full collection ⁠⁠⁠here⁠⁠⁠. 2. Shop the ⁠⁠Scalp Cleanser⁠⁠ and ⁠⁠Scalp Essence⁠⁠ from ⁠⁠T Stem Care. ⁠⁠3. Shop ⁠⁠⁠⁠⁠⁠⁠Ulyana Organics'⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Tallow Wild Yam Cream⁠⁠⁠⁠⁠⁠⁠, and use code ⁠⁠⁠⁠⁠⁠⁠CHLOE10⁠⁠⁠⁠⁠⁠⁠ 10% off your order.Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

In Episode 119 of the Diary of a UK Stock Investor Podcast this week:- (00:00) Show Start (03:41) A brief review of the UK markets in December 2024 (05:05) The Window of Opportunity (11:20) How My Stock Portfolio Gained £70 in December 2024 (27:08) Buffet on Finding a Business with a Moat (28:35) A deeper look at Construction business CRH plc (33:19) A 15yo's First Stockpick - JD Sports plc Diary of a UK Stock Investor Podcast is a show for everyday long-term retail investors, hosted by Chris Chillingworth. The podcast is unique in that it serves as a place for Chris to reflect on the highs and lows of long-term UK stock investing, as well as sharing detailed updates on how his own portfolio is growing. With new episodes every Thursday, and a detailed update on his quest to reach £1,024,867 in portfolio value by 2043, episodes often discuss investing education, strategy, mindset, ideas and even stock picks and analysis. The show, which now has an active following of over 4000 downloads a month, is curated by Chris Chillingworth, a UK investor for over a decade whose stockpicks have achieved a 18% annual average return between Jan 2014 - Nov 2024. Email Chris at the show on chris@chrischillingworth.com Checkout the website https://chrischillingworth.com 

Poslední díl roku 2024 podcastu Dějiny bez konce jsme věnovali ohlédnutí se za uplynulým rokem v historii. Probrali jsme sérii o rozkladu poválečného antifašismu, kterou připravovali pro Alarm Ondřej Bělíček a Ondřej Crhák. Zastavili jsme se zejména u posledního rozhovoru s Martou Havryshko o vzpomínání na druhou světovou válku na Ukrajině, kde v souvislosti s probíhající válkou s Ruskem v současné době dominují krajně pravicové paměťové narativy. Ondřej Bělíček pak na toto téma doplňuje, že se těší v příštím roce na vydání nové knihy historika Quinna Slobodiana, která se věnuje ideologickým kořenům americké krajní pravice, trumpismu, ale také jak a kdo tyto myšlenky šíří v Evropě. Součástí dílu je také rozhovor s historikem Thomasem Martinem o jeho knižní novince The End of Empires and a World Remade: A Global History of Decolonization (Konec impérií a přetvoření světa. Globální dějiny dekolonizace), která vyšla v nakladatelství Princeton. Thomas Martin působí jako profesor na univerzitě v Exeteru a je považovaný za předního odborníka na dějiny francouzského kolonialismu. ✏️ Tipy: Jan Slavíček, Eduard Kubů - Politika v družstvech - družstva v politice Historie-Otázky-Problémy 2024/2: Sociální a kulturní dějiny vojenství Libor Denk, Barbora Dietrichová, Vojtěch Kessler (edd.) - Šťastné a veselé. České Vánoce ve vzpomínkách pamětníků Alan P. Marcus - Confederate Exodus

In this episode, we dive into the interplay between the hypothalamic-pituitary-adrenal (HPA) axis and the microbiota-gut-brain (MGB) axis, highlighting their bidirectional communication through endocrine, immune, and neural pathways. We'll explore how gut-derived metabolites like short-chain fatty acids (SCFAs) and endotoxins like LPS influence HPA axis activity; conversely, we explore how dysregulated cortisol can impact gut barrier function, immune signaling, and more. We also discuss testing including stool analysis and DUTCH tests. Topics: 1. HPA Axis and MGB Axis Interaction The HPA axis and microbiota-gut-brain (MGB) axis are bidirectionally connected. Gut microbiota influences the HPA axis via metabolites and more 2. Overview of the HPA Axis and Cortisol Secretion Stress signals activate the hypothalamus to release CRH. Stimulates the anterior pituitary to produce ACTH. ACTH signals the adrenal cortex. The adrenal cortex releases cortisol, which binds to glucocorticoid receptors (GRs). 3. Cortisol Dysregulation Impact on Intestinal Health Intestinal lining anatomy: epithelial cells Tight junction proteins regulate nutrient trafficking and prevent pathogen entry. The mucosa contains epithelial cells, connective tissue (lamina propria), and a thin muscle layer. 4. Glucocorticoid Receptors (GRs) in the Gut GRs are intracellular receptors that modulate gene expression when activated. Cortisol binding causes GRs to translocate to the nucleus and bind DNA at GREs. GRs on epithelial cells. Modified tight junction protein expression. 5. Gut Microbiome's Role in HPA Axis Activity SCFAs, including acetate, propionate, and butyrate, produced by gut bacteria fermenting dietary fiber. SCFAs support gut integrity, reduce inflammation, and act as signaling molecules. A diverse and healthy microbiome can enhances HPA regulation via SCFAs. 6. SCFA Modulation of the HPA Axis SCFAs and cortisol. Research highlights SCFAs' ability to attenuate stress-induced cortisol increases. 7. Dysbiosis - Impact on the HPA Axis Dysbiosis reduces SCFA production, impairing gut barrier integrity and immune signaling. Dysbiosis, intestinal hyperpermeability and LPS. LPS activates inflammatory pathways. 8. Inflammation and Dysregulated HPA Activity Chronic inflammation and cortisol. Inflammatory signals from the gut exacerbate systemic and neural stress responses. 9. Symptoms of HPA Axis Dysfunction Chronic fatigue, disrupted sleep, mood disturbances... 10. Identifying Root Causes Dysbiosis, chonic infection / chronic inflammation... DUTCH Test Stool analysis Thanks for tuning in! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

Join Eduardo Gomez Mendoza, SVP and Head of CRH Ventures as he shares his perspective on how we can scale the most-needed hardware tech to deliver industrial decarbonisation.  Welcome to this special edition of the Decarb Connect podcast featuring one of the 50+ speakers at Decarb Techinvest. We will be exploring, through a few conversations, how we scale up (beyond series B) and truly commercialise the hardware tech that transform our most essential, but co2 intensive, sectors. Eduardo Gomez Mendoza, SVP and Head of CRH Ventures, took on the mission to launch and grow CRH Ventures back in 2022 – in this conversation we talk about how his and the team's focus has developed, along with his view of how we can scale the most-needed hardware tech to deliver industrial decarbonisation. We take a look at CRH Ventures' 4 main areas of interest - Decarbonisation, Water, Circularity and Productivity… important to the core business as well as their sustainability goals. It was great to hear about the 4 announced investments in companies helping to create more sustainable outcomes for industry, there is also a a strong pipeline with more investments due to be announced this soon. Listen in to get Eduardo's perspective on these points:Asset-heavy tech require significant capital to scale – can early tech show they can get the unit economics to work profitably at scale?What times of tech roadmaps and leadership team capabilities are essential for them?More capital is available for climate tech and hard tech and investors are more comfortable with asset-heavy businesses – but how are the expectations and needs of investors changing?The value in having strong technical and commercial teams around the world – what can CRH deliver that other CVCs may not?How are FOAK projects moving from plans to reality (with examples) Show Links: Connect to Eduardo Gomez Mendoza, Head of CRH Ventures and learn more about CRH VenturesConnect with Alex Cameron, Founder of Decarb Connect and find out more about our work with the leaders in industrial decarbonizationLearn more about Decarb TechInvest and the other speakers and guests joining Eduardo onsite If you've enjoyed this podcast –join us in Boston from 10-11 September 2024 for Decarb TechInvest.  Eduardo is one of over 50+ speakers from across the industrial decarb tech and investor space. This is the only event that brings both high quality investors (including Eduardo) together with best in class hardtech teams at Series B+. Join us and help drive the momentum and partnership models that will define the next decade of industrial climate tech expansion.  Learn about our Sponsor: Janno MediaMany thanks to our production partner and sponsor Janno Media for their support in delivering this podcast. They continue to facilitate great conversations that connect us with our audience, and their skills and expertise mean we can concentrate exclusively on generating great content to engage, inform and inspire.  

Repatriace umění, dekolonizace muzeí. Evropa vrací vzácné historické předměty do Afriky. Proč? Proč až teď? O jakém umění je řeč? Jaké kousky na návrat teprve čekají? A týká se to jen Afriky? Otázky na Ondřeje Crháka z Náprstkova muzea. Ptá se Matěj Skalický.

Repatriace umění, dekolonizace muzeí. Evropa vrací vzácné historické předměty do Afriky. Proč? Proč až teď? O jakém umění je řeč? Jaké kousky na návrat teprve čekají? A týká se to jen Afriky? Otázky na Ondřeje Crháka z Náprstkova muzea. Ptá se Matěj Skalický.Všechny díly podcastu Vinohradská 12 můžete pohodlně poslouchat v mobilní aplikaci mujRozhlas pro Android a iOS nebo na webu mujRozhlas.cz.

In this week's episode we'll learn about the clinical benefit of complete remission with partial hematological recovery, or CRh, in patients with Acute Myeloid Leukemia (AML) treated with molecularly targeted drugs. Then we'll hear about a large cohort of patients with PNH were studied to detail PNH-related thrombotic events, unravel determinants of thrombosis, and evaluate anti-coagulation strategies. Finally, we'll see how new research shows that SOX11 expression is restricted to EBV-negative Burkitt lymphoma, and is associated with a specific genetic landscape. Featured Articles:Complete Remission with Partial Hematological Recovery as a Palliative Endpoint for Treatment of Acute Myeloid Leukemia Paroxysmal nocturnal hemoglobinuria-related thrombosis in the era of novel therapies: a 2043 patient/years analysis SOX11 expression is restricted to EBV-negative Burkitt lymphoma and associates with molecular genetic features 

In this episode we discuss adrenal insufficiency  You can have either primary, secondary, or tertiary adrenal insufficiency. Primary adrenal insufficiency is also called Addison's disease. When you have this type, your adrenal glands are damaged and can't make the cortisol you need. They also might not make enough aldosterone. Secondary adrenal insufficiency is more common than Addison's disease. The condition happens because of a problem with your pituitary gland, a pea-sized bulge at the base of your brain. It makes a hormone called adrenocorticotropin (ACTH). This is the chemical that signals your adrenal glands to make cortisol when your body needs it. If your adrenal glands don't get that message, they may eventually shrink.  This is the type our guest on this week's episode is dealing with. Tertiary is due to hypothalamic disease and a decrease in the release of corticotropin releasing hormone (CRH). Causes can include brain tumors and sudden withdrawal from long-term exogenous steroid use (which is the most common cause overall) The most common cause of Addison's disease today is an autoimmune problem, when your immune system malfunctions and attacks and damages your own body, in this case, your adrenal glands.

Welcome back to Market Mondays on the Earn Your Leisure channel! In today's episode, we're diving into a range of hot topics that are shaping the financial world: Market Mondays w/ Doha Mekki (DOJ Antitrust Div - PDAAG) - We kick off the discussion with our thoughts on OpenAI's latest innovation, the Incredible video generator SORA. How will this technology impact content creation and digital marketing? - Jeff Bezos has sold over $2 billion in Amazon stock for the third time this month. Is this a red flag for individual investors, or is there a bigger picture to consider when elites liquidate their stocks? - Morgan Stanley has spotlighted Ameriprise Financial and CRH as top stock picks. Do you agree with their assessment? Let's break down the potential of these recommendations. - The valuation debate heats up as we compare NVIDIA and Google. Is NVDA truly worth more in the current market scenario? - Troy and Rashad weigh in on which companies to place puts on: Southwest, Intel, Footlocker, or Coursera. Hear their insights and strategies. - Bitcoin's streak of weekly gains puts a new record high within reach. When do we predict this all-time high will be shattered? - We explore top semiconductor stocks, including Magnachip, Himax Technologies, ASEW Technology, Arteris, and Navitas Semiconductor. Which of these have the potential to skyrocket? - Reflecting on financial regrets, we share the top mistakes we wish we could do over. - Interesting trend: single women own more homes than single men. Let's discuss the implications of this in today's market. - Capital One's potential acquisition of Discover Card – could this be the next big merger to watch? - With U.S. equities now comprising 70% of the MSCI World Index, we address concerns over market concentration. - Plus, a special segment with Principal Deputy Assistant Attorney General Doha Mekki discussing the critical intersection of antitrust laws, economic rights, and civil rights. Join us as we unravel these topics and provide actionable insights for your financial journey. Don't forget to share your thoughts in the comments, like, and subscribe for more financial wisdom every Monday. #MarketMondays #FinancialEducation #StockMarket #OpenAI #JeffBezos #InvestmentTips #Bitcoin #SemiconductorStocks #AntitrustLaws #EconomicRights #CivilRights #EYLSupport this podcast at — https://redcircle.com/marketmondays/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

Links mentioned in Episodewww.betterwithcarbo.com/2 - The Smart Approach: 5 Questions to ask yourself Before Trying SupplementsStress, Neurotransmitters, and Inflammation:Overview of the relationship between stress, neurotransmitters (adrenaline, norepinephrine, cortisol), and inflammation.Explanation of how prolonged stress leads to elevated levels of inflammatory cytokines and cortisol, potentially causing health problemsHPA Axis and Cortisol Tolerance:Detailed explanation of the Hypothalamus-Pituitary-Adrenal (HPA) axis and how chronic stress can lead to cortisol tolerance.Emphasis on the role of cortisol in controlling sleep, breaking down glucose, and suppressing the immune system.CRH and Gut-Brain Axis:Introduction to corticotropin-releasing hormone (CRH) triggered by stress and its impact on gut health.Discussion of how chronic stress can lead to leaky gut and inflammation through CRH.Main Points: Nutrients to Combat Stress and InflammationL-Theanine:Explanation of L-theanine as an amino acid found in tea leaves.Detailing L-theanine's ability to enhance GABA, serotonin, and dopamine production for relaxation.Suggested tea sources and timing for optimal benefits.Tyrosine:Overview of Tyrosine as an amino acid essential for neurotransmitter production.Emphasis on its significance during periods of high stress.Tyrosine-rich food sources and their incorporation into the diet.Magnesium:Explanation of magnesium's role in stress management at the cellular level.Highlighting its involvement in regulating the HPA axis and potential depletion during high stress.Magnesium-rich food sources and creative ways to include them in the diet.Probiotics:Introduction to the gut-brain axis and the bidirectional communication between gut and brain during stress.Importance of probiotics in supporting gut health, reducing inflammation, and improving mood.Probiotic-rich food sources and their incorporation into the diet.B Vitamins:Overview of the significance of B6, B9, and B12 in neurotransmitter production and myelin maintenance.Importance for individuals with conditions like MS.B vitamin-rich food sources and practical ways to include them in the diet.Vitamin C:Detailing Vitamin C's role as a cofactor for neurotransmitter synthesis during stress.Encouragement to consume Vitamin C-rich foods to support mood improvement.Vitamin C-rich food sources and delicious ways to incorporate them.Choline:Explanation of Choline's role in brain health, neurotransmitter function, and cell wall integrity.Importance of Choline-rich foods in supporting cognitive and emotional balance.Choline-rich food sources and creative ways to include them in the diet.Omega-3 Fatty Acids:Introduction to the anti-inflammatory effects of Omega-3 fatty acids.Connection between Omega-3s and reducing the production of inflammatory cytokines.Omega-3-rich food sources and simple ways to include them in the diet.Vitamin D:Emphasizing the role of Vitamin D in making the brain more efficient at managing stress.Importance of maintaining adequate Vitamin D levels.Vitamin D-rich food sources and the role of sun exposure.Follow along: https://betterwithcarbo.com/ Instagram

Paul Barclay is the owner and founder of Custom Reptile Habitats. In the episode, Paul discusses his background in the pet industry and the inspiration behind starting his own business. He talks about the lack of quality reptile enclosures and how he saw an opportunity to create something better. Paul also emphasizes the importance of big box pet stores in the industry and the need for better understanding and collaboration among different segments of the industry. He addresses the controversy surrounding the treatment of animals in breeding facilities and the importance of giving animals time to adapt to new environments. Paul concludes by expressing his passion for helping people and animals through his business. SHOW NOTES: https://www.animalsathomenetwork.com/185-crh/ WE DISCUSS: 0:00 Coming Up 2:42 Welcome Paul & Background 15:35 Reptile By Mack & Understanding Big Box Pet Stores 27:20 Understanding the Pet Industry 38:02 CRH & Pateron Ad Read 38:51 Pushing Reptile Enclosures Forward 47:07 Moving on from Reptile By Mack & Starting CRH 57:39 Custom Reptile Habitats & Maximum Reptile 1:08:21 900 Gal Ball Python Enclosure with a Tub 1:23:42 Giving Reptiles Time to Adapt & Increasing Minimum Standard 1:39:12 Where do Big Box Pet Stores Fit in Herpetoculture? 1:48:28 Animal Rights, PeTA & Reptiles by Mack 2:01:14 What is the Future of Herpetoculture? 2:07:55 Closing Thoughts 2:14:26 Outro LINKS FROM THE EPISODE: CHECK OUT Custom Reptile Habitats HERE  https://customreptilehabitats.com/ https://www.instagram.com/customreptilehabitats/ https://www.facebook.com/CustomReptileHabitats/ https://www.youtube.com/c/customreptilehabitats Support, Subscribe  & Follow: CHECK OUT Custom Reptile Habitats CLICK HERE SUBSCRIBE TO THE PODCAST NETWORK: SPOTIFY► https://spoti.fi/2UG5NOI Support us on Patreon: patreon.com/animalsathome Subscribe on YouTube: https://www.youtube.com/c/AnimalsatHomeChannel Follow on Instagram: @animalsathomeca

As we begin a new year, it's crucial to understand how the Cortisol Awakening Response (CAR), which is closely tied to our sleep patterns and overall well-being, can impact our ability to wake up refreshed and ready to tackle the day. We'll explore the intricate biochemical processes that govern the CAR, the factors that can lead to its dysregulation, and practical strategies to reset cortisol's diurnal rhythm for optimal energy and productivity (so you can go above and beyond with your goals in 2024). Topics: 1. Introduction - Importance of discussing the cortisol awakening response - Connection between cortisol awakening response and sleep regulation - Overview of the cortisol-melatonin diurnal cycle 2. Retinal Ganglion Cells (RGCs) and Light Response - Role of photoreceptor cells in the retina - Specialized cells - Retinal Ganglion Cells (RGCs) - Melanopsin in RGCs and its light sensitivity - Generation of electrical signals in response to light - Transmission to the suprachiasmatic nucleus (SCN) 3. Suprachiasmatic Nucleus (SCN) and Light Signals - Integration of light signals by SCN - SCN's role in assessing day-night cycle - Adjustment of the body's internal clock 4. Intracellular Signaling in SCN - Activation of intracellular signaling pathways - Role of CREB (transcription factor) - Transcription and translation of CRH within SCN neurons - Release of CRH into the bloodstream 5. Adrenocorticotropic Hormone (ACTH) Release - Travel of CRH to the anterior pituitary gland - Binding of CRH to corticotroph cells - Increase in cyclic adenosine monophosphate levels - Stimulation of ACTH synthesis and release 6. Cortisol Production - ACTH reaching the adrenal glands - Stimulation of cortisol production - Importance of cortisol in the context of discussion 7. Dysregulation of Cortisol Awakening Response - Factors leading to high or low Cortisol Awakening Response - Impact on energy levels and waking up - Focus on the case of chronic fatigue 8. Addressing Dysregulated Cortisol Awakening Response - Assumption of no underlying root causes - Strategies for resetting cortisol's diurnal rhythm - Aligning light exposure with natural environment - Increasing morning light exposure - Incorporating physical activity, including high-intensity exercise earlier in the day - Cold therapy as a stimulatory strategy for the morning - Avoiding overstimulation at night (caffeine, intense exercise, loud sounds, alcohol, LIGHT) 9. Supporting Melatonin for Cortisol's Diurnal Rhythm - Importance of melatonin in sleep regulation - Consuming foods rich in melatonin or precursors - Exploring endoluten, a pineal peptide bioregulator Thanks for tuning in! ⁠⁠⁠⁠Book An Intro Coaching Call with Chloe Porter⁠⁠⁠⁠ Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok ⁠⁠⁠⁠@chloe_c_porter⁠⁠⁠⁠ Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more! Or visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠linktr.ee/synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

Chris Hall is a first generation multi-racial Caribbean American who was raised by a single mom. He tells us his story growing up in NY City and he dealt with poverty and being a bit unusual because he looked different. As it turned out, he also was diagnosed with Attention Deficit Disorder and Dyslexia although he did not learn his diagnoses until he was in high school. Like many undiagnosed children he felt out of place. Finally learning of his medical issues he began working to understand and grow. Chris went to college and successfully studied and graduated. He tells us how he eventually substituted some Eastern medical practices for the medications his doctor prescribed for him to help with his ADD. I asked him if he felt that his new regiment regarding ADD was better than Western medications. You will hear that indeed he feels more improved now. Chris eventually began working at Boeing in various financial roles. He always credits good mentors and teachers with his successful building of confidence and success on the job. In 2017 he decided to give back by becoming a mentor and coach to others. He also has, as he puts it, started a side hustle as a public speaker. So, clearly he keeps busy and loves the activity. He will tell us, however, that it is important to take time to relax, unplug and think. I leave the rest for Chris to tell. All I will say is that clearly he is unstoppable. I hope you see that as well. About the Guest: Christopher Hall is a 1st Generation multi-racial Caribbean American, who was born and raised in NYC by a single mom. Ever since young, Chris has been passionate about helping others and leading his life with positivity, determination, empathy, passion, kindness, and grace! Being born and raised in the heart of NYC was not easy! As the only child of an immigrant mother who did not attend college, Chris and his mom went through hard times. Both financially and in regard to learning as he struggled with a learning disability (ADD/ADHD/Dyslexia) when younger. However, through these tribulations, he was fortunate enough to have had mentors, teachers, and a wonderful tutor Krish Kamath who went out of their way to teach him and provide him with guidance. It was through this that Chris became fearless, confident, and resilient. These times built his character and truly instilled a drive and burning passion into wanting to help others! In November 2017, Christopher channeled this passion of helping others through mentorship, and his goal was simple: He was eager to mentor people and help them find their WHY and their own passion! Chris truly believes everyone has a deep inherent why that is so powerful, yet many do not know what it fully is or how to access it, and are oftentimes pressured by what society wants them to be. Chris's goal is to make my vocation a vacation and help others do the same. Professionally Chris was also a 2019 member of Harvard Business School Summer Venture in Management Program (a highly selective residential week-long PreMBA student at Harvard Business School campus which exposes you to real-world Business Cases) and was a recruiter and ambassador for the SVMP Alumni Association. Chris Hall is also a 2019 Forbes 30 Under 30 College Scholar. From a professional perspective, Chris Chris has interned twice for The Boeing Company as a Financial Analyst and was extended a full-time offer for Boeing's Top Finance rotational program called the Business Career Foundation Program (now reprogrammed as the FCFP) which exposed him to 6 different roles within Finance, Strategy, Contracts, HR, and Sales within 2 years. Outside of this Chris, use to work as a Teller in Banking, worked as a Sales Consultant, Senior Sales Consultant, and Sales Trainer for an Internal Currency Exchange Retail Corporation, and was set to get promoted to Assistant Sales Manager (prior to COVID in March of 2020). Chris was also extended an offer to Intern at Morgan Stanley as a Compliance Analyst in New York during the Summer of 2018. Finally, Chris has received interviews, Superdays, and/or offers for multiple Fortune 500 Companies including Goldman Sachs, Google, Blackstone, Morgan Stanley, JP Morgan, Boeing, Airbus, Bloomberg, Bank of America, Lockheed Martin, HSBC Bank, Fox News, Amazon, Barclays Investment Bank, etc. This is what inspired Chris to begin mentoring others after having experience with these firms. Up to date, Chris have mentored over 700 people across 5 continents in person (from November 2017 to date) and virtually and has helped over 12,000+ people through his YouTube Videos! Additionally, his LinkedIn posts have amassed over 100,000+ views altogether. Chris's primary goal as an individual is to give back and serve others! Whether that is offering the top quality products in a corporation, to helping individuals during times they need it the most. Chris's success is making other people and companies successful! Chris is eager to take upon new challenges and grow in this beautiful journey of life. It is my drive and my personal values that influence me to work hard and even harder, every single day! Outside of work and mentorship, Chris is very passionate about Mental Health, Self-Care, Self-improvement, Traveling, Nature, Singing, Hiking, Archery, YouTube, Finances, & fitness! Ways to connect with Chris: LinkedIn: https://www.linkedin.com/in/christopherrangonh/ Calendly: (To book a 1:1 Mentorship Session) https://calendly.com/christopher-rangon/mentorship TikTok: https://www.tiktok.com/@chris_rangon/ Youtube: https://youtube.com/@skateboardcrh12 **Instagram: ** https://instagram.com/chris_rangon https://www.instagram.com/christopherrangonspeaks/ About the Host: Michael Hingson is a New York Times best-selling author, international lecturer, and Chief Vision Officer for accessiBe. Michael, blind since birth, survived the 9/11 attacks with the help of his guide dog Roselle. This story is the subject of his best-selling book, Thunder Dog. Michael gives over 100 presentations around the world each year speaking to influential groups such as Exxon Mobile, AT&T, Federal Express, Scripps College, Rutgers University, Children's Hospital, and the American Red Cross just to name a few. He is Ambassador for the National Braille Literacy Campaign for the National Federation of the Blind and also serves as Ambassador for the American Humane Association's 2012 Hero Dog Awards. https://michaelhingson.com https://www.facebook.com/michael.hingson.author.speaker/ https://twitter.com/mhingson https://www.youtube.com/user/mhingson https://www.linkedin.com/in/michaelhingson/ accessiBe Links https://accessibe.com/ https://www.youtube.com/c/accessiBe https://www.linkedin.com/company/accessibe/mycompany/ https://www.facebook.com/accessibe/ Thanks for listening! Thanks so much for listening to our podcast! If you enjoyed this episode and think that others could benefit from listening, please share it using the social media buttons on this page. Do you have some feedback or questions about this episode? Leave a comment in the section below! Subscribe to the podcast If you would like to get automatic updates of new podcast episodes, you can subscribe to the podcast on Apple Podcasts or Stitcher. You can also subscribe in your favorite podcast app. Leave us an Apple Podcasts review Ratings and reviews from our listeners are extremely valuable to us and greatly appreciated. They help our podcast rank higher on Apple Podcasts, which exposes our show to more awesome listeners like you. If you have a minute, please leave an honest review on Apple Podcasts. Transcription Notes **Michael Hingson ** 00:00 Access Cast and accessiBe Initiative presents Unstoppable Mindset. The podcast where inclusion, diversity and the unexpected meet. Hi, I'm Michael Hingson, Chief Vision Officer for accessiBe and the author of the number one New York Times bestselling book, Thunder dog, the story of a blind man, his guide dog and the triumph of trust. Thanks for joining me on my podcast as we explore our own blinding fears of inclusion unacceptance and our resistance to change. We will discover the idea that no matter the situation, or the people we encounter, our own fears, and prejudices often are our strongest barriers to moving forward. The unstoppable mindset podcast is sponsored by accessiBe, that's a c c e s s i  capital B e. Visit www.accessibe.com to learn how you can make your website accessible for persons with disabilities. And to help make the internet fully inclusive by the year 2025. Glad you dropped by we're happy to meet you and to have you here with us. **Michael Hingson ** 01:20 Well, hi there and welcome once again to unstoppable mindset. And this episode, we get to talk with Christopher Hall. Christopher is an interesting person by any standards. He's got the the luxury of being a first generation multiracial American. He is passionate about helping others and he does a lot of different things and has a lot of life experiences, which was what makes this really funny. And not only funny, but fun. I shouldn't say funny, really, because it is fun to really be able to talk about experiences, and talk about them very seriously. And so Christopher really has a lot of experiences that a lot of us don't normally get to experience and, and share up. And so I think we're all going to be drawn in by our discussion today. And with that, I want to welcome you to unstoppable mindset. Do I call you Christopher or Chris? You **Christopher Hall ** 02:25 could call me Chris. And thank you so much, Michael for having me. I really appreciate it. **Michael Hingson ** 02:30 Then I will call you Chris just not late for dinner. And Chris. Chris lives back in Pennsylvania. So right now we're recording this at 734 in the evening. He just got home from work. So you haven't had dinner yet? Have you? **Christopher Hall ** 02:46 No, I haven't. But I made sure to, you know, pass by Starbucks or for a quick snack so **Michael Hingson ** 02:55 well, what's, what's the snack today? **Christopher Hall ** 02:58 The snack was an impossible breakfast sandwich, actually. So yeah, what's **Michael Hingson ** 03:03 what's an impossible breakfast sandwich? What's that? **Christopher Hall ** 03:06 So it is a breakfast sandwich on a ciabatta bread with eggs, cheese and impossible meat? Because I'm pescetarian. So I only eat fish. Yeah. And it's pretty good. It hits **Michael Hingson ** 03:22 the spot. What kind of fish was it? You know? **Christopher Hall ** 03:25 Well, it wasn't fish that I specifically ordered this time, but it was impossible beef. So it was based beef. Got **Michael Hingson ** 03:32 it? Okay. Me. I'm a shrimp fan myself. But that's another story. **Christopher Hall ** 03:39 Awesome. Well, **Michael Hingson ** 03:41 so you are from New York. You've been in New York. Why don't we go back and start at the beginning? Why don't you tell us a little bit about you, Chris, the young person growing up and all that stuff. And let's go from there. **Christopher Hall ** 03:53 Absolutely. So I was born in 97 in Brooklyn, New York. And I was raised around Bay Ridge and I moved to Queens, New York when I was about six years old. And I lived in Queens for most of my life. Ended up going to elementary school, middle school, junior high school in Queens, went to high school in Long Island, just about 20 minutes away. And I attended Baruch College in Manhattan. And that's where I decided to pursue my degree in finance. I was really, really passionate about finance and math. And yeah, that's, that's that's just a little bit about my upbringing. At least in the New York side. New York is such a diverse place. **Michael Hingson ** 04:52 Yeah, yeah. It is. So multiracial. What races. **Christopher Hall ** 04:57 Oh, gosh. All right. I even began. So this is a long list. Okay? Yes. So both of my parents are from the Caribbean. But just through generations of family. They, they, they come from a lot of places. So, on my mom's side, she's from the island of Martinique. But I have grandparents that originate from India. On my dad's side, my dad is was born in the country of Haiti. But he's white and complexion. And both of his parents actually emigrated from England and France, to Haiti. And I also have heard that I have Middle Eastern genes in my blood as well. So very, very mixed between Caribbean, Middle Eastern, Indian, and you're up here. **Michael Hingson ** 05:55 Wow. And again, you were born where? Exactly? **Christopher Hall ** 05:59 I was born in Brooklyn, New York. **Michael Hingson ** 06:01 So there you go, the melting pot of the world by most any standard or one of them. Well, so you're you were raised by your mom, I guess primarily. So there wasn't a dad in the picture. **Christopher Hall ** 06:17 Yeah, so I was I was primarily raised by my mom. You know, she was a single parent, who just took care of me throughout throughout the highs and lows. And I owe her so much. My dad did provide moral support, or monetary support. But it was mainly my mom who took care of me. And I'm tremendously grateful for that. **Michael Hingson ** 06:49 But you had said, when we chatted before that there were a lot of hard times economically and you also have a disability or you did I don't know whether you still regard yourself as having that lunch. Tell us a little bit about all that. **Christopher Hall ** 07:02 Yes, absolutely. So my mom works as a housekeeper. She still does. And she's worked as a housekeeper for over 37 years. And while growing up, I went through a lot of tough times and tribulations and I and I saw my mom go through so many hardships. There were times that my mom would be late on rent multiple times, there were times that I was unable to afford new shoes. There were times that I saw my mom give me food. And unfortunately, I didn't see her eat. But I was very, very, very fortunate that, you know, my mom really, really took the time to instill hope and kindness inside of me. So even though I did witness that, and even though at times it did affect me, I always remained optimistic. In regards to learning disability, ever since young, I was very hyperactive. And I actually did not speak my first word until the age of four years old. So I actually went to a delayed language school. Because I did not really say my first ever syllable until the age of four. And I went to school in Brooklyn called high tech, where I was able to learn language and how to enunciate my words. And it was it was truly a challenge. And even throughout school, and I guess throughout growing up, really I struggled with attention deficit disorder, and dyslexia. And there were so many things that I struggled to understand. I struggled to comprehend. And I remember vividly taking so much longer than my peers around me. And I remember vividly studying for hours trying to work so hard and I wasn't getting the grace that I wanted. So that is that is still something that I do struggle with to this day in regards to concentration, but I have figured out ways to really navigate it. Just by understanding my body, understanding the way my mind works, and really working for myself, or working with myself rather, in order to ensure that I'm putting my best foot forward **Michael Hingson ** 10:00 So you still deal with dyslexia today? **Christopher Hall ** 10:02 Yes. Okay. Yes, I do. So, you **Michael Hingson ** 10:06 know, if I may, a couple of things come to mind, let's go back to your mom and you and you have a lot of challenges economically and so on. How do you think that has shaped your outlook on life? Today? And when what is your outlook on life? **Christopher Hall ** 10:30 That's a great question. I guess just start off with the first point. What really stood out to me, I guess, when I saw my mom experienced the things that she did, was really learning about the power of being mindful, the power of being mindful with how I save and how I spend my money. And also understanding that, you know, you should always prepare for any form of situation that does come your way. But also, at the same time, I also learned not to be afraid of investing in myself, because that's, that's so important to me. And I'm sorry, Michael, what was the other part of your question? **Michael Hingson ** 11:22 Well, the so you, you learned to be very mindful of money, you learn to be intentional about what you do, and how So it clearly hasn't made you bitter, to have gone through all that stuff. And I find that fascinating, and actually very joyous and wonderful, because I've spoken to a number of people on this podcast who have had in their own way, similar situations, that is, they have had adverse situations they've had to deal with growing up. And they come out of it, recognizing what they had, and appreciating what they had and what they have now, in so many ways, and are very articulate about it. And say that even so they wouldn't have changed, or traded their childhoods for anything, because of the fact that in reality, they learned so much because of what they had to do. Absolutely, **Christopher Hall ** 12:27 absolutely. I definitely do concur with that point. I feel like coming from humble beginnings, allows you to learn and grow. And I feel also, at least for me, personally, the most valuable things in life aren't things that are necessarily tangible, like money, it's there are things that are intangible, such as, you know, feeling joy, feeling love, you know, having peace of mind. And, and I feel like throughout the duration of my childhood, I experienced that because I have a beautiful mother that always, you know, told me about the power of having hope, of having kindness of helping others. And it allowed me to grow up with really a lot of humanity and just see that there are things that happen in life. So yeah, I'm tremendously grateful for my childhood. So so thank you for asking that question, Michael. **Michael Hingson ** 13:36 Now, at the same time, you you had learning disabilities, you had issues with dyslexia and ADHD, how did you navigate through all that and come through that it had to be frustrating? Or does it? Was it not necessarily because you really didn't know for a long time? What really was going on? **Christopher Hall ** 13:57 Yeah, great question. So I wasn't officially diagnosed with ADHD and dyslexia until I was in about ninth grade. So this was around the age of 14 or 15. And it was it was hard. And it was very, very frustrating. But my mom realized from young that I really needed extra attention when it came to schooling. And, and it was from there that my mom said, You know what I'm going to take to time to invest in my child. And literally, I am my mom's investment. I remember, you know, her taking me to programs, such as Kumaon and score. Me going to an ideal Montessori school when I was young, and you know, she would take the time to invent asked, like $350 a month, $360 a month to send me to a private school. And I remember, you know, waking up at 5am, to get ready by 545. And, you know, to, you know, go on a two hour commute, two and a half hour commute from Brooklyn to Queens. And getting that individualized learning. So I'm very, very grateful in that regard. My mom saw the power of good teachers, good programs, and education. And I feel like that just made things easier for me, because it encouraged me, because it made me realize that it's not like I'm uncapable of learning, I just learned in a different way, I just comprehend information and obtain it in a different way. And it was through learning through beautiful teachers, and individuals who pushed me that I realized, hey, you know, I am able to do that. And it gives a great sense of empowerment. And, you know, later on when school got a lot more serious, and, you know, when you're in sixth grade, seventh grade, eighth grade, you're taking very core curriculum courses in order to get you ready for high school. And I realized that I was struggling during that time. In seventh grade, I was failing a lot of my classes, I realized the importance of, Hey, maybe I do need to go to a specialized doctor to see if I could get the help that I needed. And I ended up going to a doctor that specialized in ADHD and dyslexia and things cognitively in regards to the brain. And in regards to how you process information. And I took assessments, I took tests. And that's when I received my official diagnosis. And I was very fortunate that I was actually prescribed medication. And I was able to take that during high school. And that really helped me. And that served me tremendously. And, and I took medication, I would say, from really from high school, up until my sophomore year of college, and it helped me **Michael Hingson ** 17:48 when your concentration, did you were able to stop taking the medication anymore? **Christopher Hall ** 17:54 Yeah, so currently, currently, I do not. And I was able to find natural ways to really aid with my concentration in regards to just organizing organizational skills, natural supplements. Really adequate sleep, adequate sleep helps me a lot. Going to bed at certain times also helps me a lot to with my concentration. There you go. Yeah. **Michael Hingson ** 18:28 Do you find that the natural remedies do as well or even better than taking the typical western science medication? And I asked that, because I've talked to two people on this podcast from both sides of that. So I'm just curious what your thoughts are? **Christopher Hall ** 18:46 Yeah, great question. Um, I would personally say yes. It in the very beginning, in all transparency, I did have a lot of doubt where I just said to myself, like, oh, is this really going to work? You know, I took, you know, a Western prescribed medicine for five to six years, is the natural remedy going to work the same way? So, in my mind, I started to have doubts. But I really took the time to do my due diligence and research. I looked at different natural supplements, I tried different things. And I was I was really able to see what worked well for me. And I do have to say, it does work as well. For sure. Absolutely. I think you do need to be a lot more. You know, disciplined, however, with your habits in order for it to work efficiently, you know, such as like your sleep, and your exercise for me exercising and sleep. actually helps me a lot My concentration. **Michael Hingson ** 20:02 So you, you strike me as a as a person who has been very grateful for all that you've had, which is great. One of the things that I've noticed from a lot of people who we've had the the honor to chat with, who have been through a lot of adversity and come out of it. The other end I think is the best way to put it is that not only are they grateful, but they, they love to give back, which I think is important. I think I've been doing some of that ever since being in the World Trade Center on September 11. And I decided after that, that if I could speak as people were starting to invite me to do and if I could sell philosophy and life instead of selling computer hardware, it was a lot more rewarding. So how do you do that? And how do you give back to to the world and to people because of the things that you've experienced? **Christopher Hall ** 20:56 Absolutely. Great question, Michael. So I try my utmost best to give back in any way I can. I would say you could give back in the smallest of ways. I know with me, I tried to give back through teaching, mainly through helping others. So one huge initiative that I've taken ever since 2017, when I was a junior in college, was actually to pay it forward and help people when it comes to obtaining internships and when it comes to obtaining full time jobs. And I did it originally because I had a mentor who worked at Morgan Stanley, and his name is Christopher too. And he took time out of his very busy schedule working 60 7080 plus hour weeks, just to mentor me and teach me. And, you know, I went from someone who was just very, very shy and reserved. I didn't have that much friends, to someone that was brave, eager and determined to network with people to connect with people to get to learn more about others. And it was true that I feel like my passion for giving back at least when it came to mentorship was born. So I've primarily have done that through my college campus when I was in college, and also via LinkedIn, as well. And I'm grateful to say, you know, to date, I've volunteered. And I've helped about 300, maybe 350 to 400 people for free. And I realized that I was very great at mentorship, and I realized that I was able to really give back to others and others really appreciated what I had to offer. And I turned that into a side business over time in about 2020 or 2021. **Michael Hingson ** 23:37 Wow, well, how do you continue to mentor people you've mentored hundreds of people? How do you do that without getting tired? And how do you just keep going forward? **Christopher Hall ** 23:50 That's a great question. I would have to say I, I remember my why. I know for me, when I was struggling and going through so many challenges in middle school, high school college. I had a long time tutor, teacher, someone who I would even consider a family friend who took the time to teach me and believe in me and helped me and and it was even during the times I didn't believe in myself. And I remembered vividly, you know, he would always say, you know, take the time to rest but keep on moving forward, keep on going. And during the time that I mentored people, there were times that I was dealing with other responsibilities in life there were times that I was dealing with challenges, setbacks, etc. But I am knew that if I had the opportunity to positively affect someone's life that could not only affect their life, but also affect their family's life and the people around them in a very, very positive and optimistic way. So I kept that in the forefront of my mind. And during the times that I felt tired, or if I felt like I needed a break, I took the time to get rest. Because resting and recharging is so important. But I never quit. In addition to that, I feel like what really allowed me to just remain resilient, is just by seeing how my mom approached situations, there were times that my mom worked 12 to 14 hour days, six days a week, even seven days a week. And she would always take the time to do things with a smile on her face, even though she was exhausted. And that was something that really inspired me. So ever since young, I told myself, hey, if I am tired, but if I'm doing something great, I'm going to take the time to remain resilient and go through it. And that's something that served me personally. **Michael Hingson ** 26:35 Well, you clearly had a role model that helped with your mom. And I had a lot of role models. Yeah. You had a lot of role models, but your mom certainly set set the tone. And that helped. **Christopher Hall ** 26:48 Absolutely, absolutely for sure. **Michael Hingson ** 26:52 So you have, you have said that you treat your vocation like a vacation. Tell me about that? **Christopher Hall ** 27:05 Yes. You **Michael Hingson ** 27:07 know, I'd ask you that one. **Christopher Hall ** 27:10 Yes. So, gosh, I actually did not know what the word vocation was. Until my senior year in high school. In 12th grade, I had a psychology teacher by the name of Donato manga Liuzzo. He goes by the name of Mr. Monk, for sure. And he always talked about the power of doing things that make you feel passion, and true love inside. And he always talked about the power of going after your goals and going after your dreams and not being afraid to set yourself apart. And he would always tell us this continuously class he says, you know, you'll reach an amazing stage in your life when you make your vocation a vacation, when you make your work something that you love. And I really resonated with that. And that's what I've strived to do. Ever since my senior year in high school going forward, I asked myself like, okay, you know, outside of me taking care of my needs, like financially. Does this role or does this hobby something that I'm doing? Does it make me happy? Because life, life goes by quickly. And it's and it's great to feel happy? Yeah. **Michael Hingson ** 28:49 So you graduated from college? What do you do now? **Christopher Hall ** 28:55 So I graduated from Baruch in 2019. And I currently work at the Boeing company. So I work as a finance contract specialist. And I really love what I do. Tell **Michael Hingson ** 29:11 me more about what that what that means, like what your job is? Absolutely. **Christopher Hall ** 29:15 So I help with selling V 22 helicopters to the government. So I look at contract proposals. I write drafts of letters. And I help with negotiating in order to help, you know sell these to the government such as the US Navy, and the US Army. And I've been with Boeing for about two and a half years, a little over two and a half years. And ever since I was 17 I was passionate about aviation and aerospace Bass, it was something that I've always wanted to pursue. And I was very fortunate that I wanted to pursue like a space like that, because aviation, I think is such a diverse, and really niche community. Even though aviation is so big, you see airplanes in the sky all the time you see helicopters in the sky all the time. But being able to be in an industry where you're able to serve millions of people, is something absolutely fascinating. And I'm grateful to do what I do every day. But **Michael Hingson ** 30:45 you also have started a career in coaching and public speaking. Tell me more, a little bit more about that. What got you started down that road as well? Yes, **Christopher Hall ** 30:55 absolutely. So for. So for career coaching, I guess we'll start there. In in 2017, as I mentioned earlier, I had a mentor, by the name of Christopher, and he helped me when it came to giving me the opportunity to learn more about interviews and connecting with people and things of that nature. And when I received the full time off, well, not a full time offer, actually, but an internship offer from both Morgan Stanley and the Boeing company. I was so happy, I was ecstatic. And I told my mentor Chris about this. And he said, you know, Christopher, I'm so proud of you. And I want you to remember something, I want you to do one thing, and that is pay it forward. And that was something that really, really really, you know, stuck with me. And it was something that made me feel so inspired. So ever since November of 2017. I've mentored many people around college campus. And in the end of 2019, when I was graduating from college, I realized, Hey, I'm very, very good at this, maybe I should, you know, see if I could cultivate this into a business. I've been hearing a lot of people say hey, Christopher, you, you know you have something, you are really able to inspire and help others and connect other people as well with their opportunities and and help people find their why and their passion, you should turn this into a business. So in 2020, I was thinking about it. And I'm asking myself, okay, how can I do this? And unfortunately, COVID happened. It really hit New York City hard in March of 2020, with with the lock downs. And I told myself, you know what, okay, I'm going to try my utmost best to help as many people as I can, because I see people getting laid off, left and right. And that simple initiative of wanting to really help people as much as I could, turned into me, putting a lot of posts on LinkedIn sharing, value added information about how to search for jobs during the time of the pandemic, how to ask, informational, or how to have informational interviews in an appropriate manner, what questions to ask, after an interview, how to answer specific interview type questions, and I would create these posts on LinkedIn. And I took the initiative to set up 45 minute long calls for free from 12pm to 9pm, seven days a week, from April of 2020 through August of 2020. And during that time, that was about 11 people a day, max that I mentored. During that time I mentored over 200 people within that four month timeframe. And in August of 2020, I decided I want to pursue this and I want to transform this into a you know small time business. And by small time I don't think that's true. right word, but really, as a side business rather. And during that time, I said, You know what, let me use Calendly. And let me charge $20 for a 25 minute mentorship session. And I was very, very grateful that I was able to obtain clients that wanted to, you know, learn more, and they wanted to pay for my services. And it started from there. And in regards to public speaking, I would say, I had a passion for public speaking and really helping others, at least in regards to speaking in public ever since 2019. That just started with me being curious, and seeing if any elementary schools, high schools or colleges needed a speaker in order to help with providing students motivation. And it was from dare that I decided to reach out to high schools and colleges, at the time I was in Seattle. And I realized when I, you know, took the time to get out of my comfort zone and speak. It left the students feeling very, very inspired and very motivated. And that's how my passion for public speaking was born. And so far, I've I've spoken to the University of Washington, to provide a workshop there. I spoken to my alma mater, which is Razi school. And I've smoked, and I've spoken to other small various places, as well. And that's something that I'm very passionate about to how **Michael Hingson ** 37:07 did you find some of these places to speak at? like University of Washington, that's clearly quite a ways away from you. **Christopher Hall ** 37:17 Yes, so, before moving to Pennsylvania, I was actually in Seattle for about a year. And I actually have a lot of friends that attended the University of Washington. And Boeing actually has a very good relationship with the University of Washington. Well. It was it was it was very, very easy for me to leverage my connections and have the opportunity to speak there. **Michael Hingson ** 37:49 So does Boeing know that you're doing public speaking like this? **Christopher Hall ** 37:56 I would say yes. Yes, they do. I posted on LinkedIn. And I talked about, you know, my love for for, for speaking with others to, you know, you know, to my team, so they're, they're fully supportive of it? Well, **Michael Hingson ** 38:11 it certainly has continued to work out pretty well for you, needless to say, which is as important as it as it could possibly be. What have you taken in the way of lessons from your work at Boeing that has helped you and the rest of things that you do? **Christopher Hall ** 38:31 Absolutely. So I would have to say, there have been a couple of things. Number one is networking. Really, taking the time to network is truly so important. So when it comes to, you know, connecting with others, collaborating with others, when it comes to specific projects or tasks, building rapport is truly so important. Because at the end of the day, people will give you opportunities if they know you, and they're able to vouch for your work ethic, if they know who you are. What is your personality, what you bring to the table. So that is that is truly important, you know, networking and fostering relationships, I would say is number one, number two, one thing that I've learned is, and it really alludes to number one is you know, ensuring that you have good rapport with people, as much as you can never burn your bridges. You know, the world is very big, but it's also very, very smart. People talk and individuals know each other. So always take the time. To put your best foot forward and lead with transparency, lead with love, you know, always take the time to serve others in any way you can, it really helps tremendously. And that is, that is something that I've learned and, and number three, I would have to say, one of the biggest things that I've learned through Boeing is Never be afraid of interacting with others. I know throughout my time, you know, at the Boeing Company, there were there were times that I was intimidated to reach out to a senior vice president or a managing director, or CEO, of you know, you know, Boeing Business Unit. But I realized throughout my time, people are eager to connect, and really help. At least, that's most people. So about what I would say is, I guess the common theme between all of those three things is not being afraid to put yourself out there. And really take the time to add value, and do good. **Michael Hingson ** 41:23 As a motivational speaker, what theme Do you think resonates most with your audiences? And why is it important today? **Christopher Hall ** 41:33 Yes, so I would have to say, resilience is, is something that definitely resonates with a lot of my audience members, because the thing about life is, life will have its challenges, and at times, it will be unpredictable. And there will always be uncertainty, there will always be, you know, individuals that may not recognize or see your potential. And one thing that I feel that my audience really connects with me about is empathy and, and really taking the time to just understand how to navigate through hardships. And that is something that I speak about a lot. When I mentor and when I speak to crowds as well. It's, it's the power of overcoming challenges. Taking the time to go the extra mile, learning how to believe in yourself, when a lot of people don't believe in you. Taking the time to cultivate your mindset, when you are in a very, very, very dark place. These are all the things that I feel my audience relates with a lot, because a lot of my mentees, one thing that I've realized in regards to a common theme is is all of them are intelligent, all of them are capable. But there are life situations and challenges that people go through that make things less than ideal, someone may go through a layoff someone may have a death in their family, someone may have gone through trauma. And oftentimes, it's very, very easy for people to lose hope in themself. You know, and and there is that life challenge, right? A toxic job, a toxic workforce, whatever the case may be. So in regards to my mentorship, and with my public speaking as well. It's not just so me teaching you how to find a job, it's me giving you the tools to allow you to navigate through your emotions to allow you to find your why to find your passion to find what makes you spark. And, you know, make you go after that. So so I feel like that's a very important critical theme. Especially, and what I discuss on a day to day basis, **Michael Hingson ** 44:36 so what kind of tools do you give people? Um, so you talk about the fact that they face challenges and so on. What do you actually teach them in the way of tools to deal with that? **Christopher Hall ** 44:45 Absolutely. So I teach them different things, primarily through affirmations. I teach them about the power of affirmations. The power of journaling, the power of taking the time to navigate through your emotions, and really take the time to write down how you're feeling? What are the challenges you're going through? And where do you see yourself going to moving forward? What are what are things that you want to start doing? What are things that you want to stop doing? What are things you want to continue doing as well. I talked to people about the power of mindfulness, and about the power of also meditation as well. You know, one thing that I'm very, very big on is spirituality, and how it helps people. More so with connecting with your True Self with who you are. And that is something that I really do feel, helps a lot of individuals as well, because everyone has a personal story. And everyone has a challenge and a struggle that a lot of people don't know about. **Michael Hingson ** 46:08 Tell me, you've used mindfulness as a term a number of times, what does that mean? Exactly? **Christopher Hall ** 46:14 Mindfulness just means being aware, at least for me, being aware of your emotions, and your thoughts, how they make you feel in that moment, and how they drive your behavior. So what are your patterns? When you feel stressed? What are your patterns? When you feel discouraged? And by patterns? I mean, what do you tend to do in that moment? What do you resort to? Water? How do you face it? What do you run away from? What do you incorporate in your day to day habits in your day to day life, things of that nature. Another part of mindfulness is how you make others feel. But in regards to one on one personable mentorship, I really concentrate on helping others really navigate how they feel with their own emotions, and how they navigate through that. **Michael Hingson ** 47:25 Well, you keep pretty busy between speaking and working at Boeing and coaching. How do you do that? And keep up a work life balance? How do you find time to rest and rejuvenate yourself, if you will? **Christopher Hall ** 47:44 Absolutely. So I do it through a couple of ways. And that's such a great question you asked Michael. I guess number one, I'm really, really passionate about mentorship and helping others. And I'm very passionate about bowing. So one thing that I feel that's great is that even if I do have a busy schedule, it doesn't exhaust me or drain me, I may feel tired, naturally. I may want to pause, take a break and you know, be re energized. But it doesn't drain me in the sense where I dread that I'm doing what I'm doing. I love everything that I do. So in regards to what makes me feel energized. There are a couple of things that do number one is music. I am a very, very, very big fan of all styles of music. I love to play the drums. And I've played them on and off for about 17 years. So you know listening to music in the car. While I'm taking a walk outside while I'm running, that that really helps me a lot. Speaking of taking a walk outside and running one thing that I love to do is I love to connect with nature. So I love to go for walks I love to hike. I love to explore new different neighborhoods, like just different areas in general, and that really energizes me. Another thing too is talking with with with great friends with amazing people. So it could be something as small as meeting up with a friend to grab lunch or dinner or playing basketball or watching a movie. Or or even doing something as simple as you know, staying on The couch and petting my cat. Right? Those are those are all the things that re energize me. And it makes me feel supercharged for you know, when I do the things that I need to do? **Michael Hingson ** 50:16 Well, so what's your favorite place to go? You see you like to do a lot with nature and go places do you have a favorite place? **Christopher Hall ** 50:25 Well, I, I usually don't like to give people favorite places where I like to go. But I guess one place that I used to like to go to, in Seattle was was was was a beach that I was at in Edmonds, Washington, where I used to live that. So as kind of like, a go to activity right after work, I would drive from my house and the beach would be about seven to 10 minutes away. And I would, you know, drive up, see the sunset, see the water, you know, come up to shore, you know, smell the air, see the mountains and the horizon? See, you know, the dogs playing, and that gave me a lot of peace. Right now, currently, I like to just, you know, walk in and run on a lot of trails. So I feel like that's, that's, that's my favorite activity. Oh, **Michael Hingson ** 51:35 well, it gets you away from the other stuff. And it gives you time to think which is, of course, part of what I suspect that you're really thinking about and looking at is to get that time to decompress a little bit. **Christopher Hall ** 51:48 Absolutely. Absolutely. For sure. So, **Michael Hingson ** 51:51 you've talked about motivational speaking, and all that. And as long as you love to mentor, what advice do you have for someone who might want to become a motivational speaker or a coach? **Christopher Hall ** 52:03 Absolutely, I would say, take the time to find out what you really love. Number one, what you are really good at or something that you feel like are starting to get good at, and take the time to really study that craft. I know this may sound like very generic or cliche advice, but taking the time to learn from others, right? That could be through reading a book, checking out a YouTube video, you know, reaching out to someone on LinkedIn that inspires you just to learn more about them and have a coffee chat with them. That can really allow you to grow and learn more about a specific space. And it could really inspire you to try new things. And go ahead and try them. That's, that's, that's really the most important part, take action and do. And I know that this is something that I was personally struggling with, for a long time, and I still do struggle with it transparently, you know, in my journey, sometimes you ask yourself, like, oh, my gosh, I really want to do this, that and the third, where do I begin? And you know, the answer to that is, you just need to start, start very, very small. And it can be something as you know, offering to volunteer at an elementary school or middle school. Volunteering to speak at a nursing home, volunteering to speak at your alma mater, like in college, maybe speaking at an organization that you were a part of on campus. All of these things can allow you to grow and learn and get more experienced, so you feel comfortable with speaking. And that's how you're able to grow in in regards to mentorship. Just take the time to mentor someone. It could be something as simple as mentoring your friend when it comes to their resume, giving them a mock interview, giving them advice on what are some of the things that work for you. That help you get a full time job. And just mark just start small and work your way up. There's no such thing as as an overnight success. You know, for for me, career coaching is is something that I've been doing for six years. Close to six years, November would be six and By all means, I'm not perfect at it. But I know that I'm getting better every single day. So it's, it's practicing taking action and putting yourself out there, **Michael Hingson ** 55:09 which makes a lot of sense, practice is the only way you're going to really get better. And thinking about what you do. You're absolutely right. So what for you? What are your future or your future aspirations for working as a motivational speaker? And as a coach, and just as important, what are your aspirations for life at Boeing? **Christopher Hall ** 55:35 Absolutely. So I would say, aspirations in regards to life of Boeing, I'll start with that is take the time to, you know, work hard and really grow in my field. That is something that I'm very passionate about, I would say, long term, I really want to get into sales, at Boeing sales and marketing, that is, that is the space that I'm very passionate about. And, you know, grow, have the opportunity to collaborate and, and just have the opportunity to work with clients. I love working with people. So so that's something that I'm very inspired about. So that's, that's on the buying side, in regards to motivational speaking, and in regards to career coaching, I would say really take the time to continue helping more people. I really want to make more content online. I've been starting to post videos more on my tic tock and by all means they are not perfect. But I've been but I've been taking action. I have an account called Chris underscore Rangan ra n Gln. So I've been posting a couple of tech talks. And I want to do more of that. I also intend on posting more YouTube videos, that is something that I'm very passionate about in regards to content creation. And I want to cultivate my own website, I want to build my own website, around career coaching, around public speaking. And I guess it's not I guess, the goal is to hopefully, you know, a very big goal is hopefully to have the opportunity to be flown out, to speak at a university or add an organization internationally. And be paid for it. So so so so that is the goal. That is the aspiration. And that is something that will take work, it will it will take a lot of time to get there. But it's something that I'm very passionate about. **Michael Hingson ** 58:06 Well, I hope that somebody listening to unstoppable mindset might find your story and all the things that you have imparted to us relevant and maybe invite you to do that very thing. We can certainly help for that. **Christopher Hall ** 58:20 Thank you. I appreciate that. **Michael Hingson ** 58:22 How do you how do you want to be remembered for your speaking and coaching careers in your time at Boeing? What what do you want your legacy to be? **Christopher Hall ** 58:33 Wow. I love this honestly been thinking about that question. For for for a couple of weeks, actually. I would say I want my legacy for speaking to be **Christopher Hall ** 58:54 Wow. You know, Christopher was someone that gave me hope. When I did not believe in myself. He took the time to inspire me and because of him, I'm better and I'm striving to make you know other in my life better. I would have to say that is that is a very, very big inspiration for me because I always aspire and try my utmost best to share love. To share positivity. I think love is so important because there's a lot of hate in the world. There's a lot of fear in the world. There's a lot of destruction in the world. So being able to share, you know, love and light is something that I'm very inspired by. For work. I want to be remembered as someone who just shared you know Over emotional intelligence, and positivity, I want people around me to feel inspired to become their best version of themselves. I want people to feel, you know, app peace and feel happy and feel encouraged to take on more work, I want people to, you know, feel motivated to take on extra projects and to really believe in themselves. So, in regards to work wise, like, I don't necessarily have, you know, a tangible goal of, Oh, I wanna, you know, sell 3500 airplanes, or things of that nature, of course, that would be great. But for me, I want to be remembered for helping others. And really helping others, I guess, just to elaborate on that more, helping others find, you know, that positivity within them, helping people find, you know, their inspiration within them feeling inspired. So, so I would say those, those are the two things. **Michael Hingson ** 1:01:26 Well, it doesn't get better than that, and great aspirations, and I, and I hope it works. You clearly can do it, you're very articulate about what you think. And I really love a lot of the, the different kinds of pieces of advice that you've given us today. So I want to thank you for that. If people want to reach out to you as a coach, or to explore you speaking, where they are. And you know, I want I want the same thing, being a keynote speaker and a public speaker, but you know, this is you. So if people want to reach out to you, how do they do that? **Christopher Hall ** 1:02:03 Absolutely. So there are a couple of ways you could do that. You could reach out to me via LinkedIn. My LinkedIn would be provided, but my handle is Christopher Rangon H. Another is via my Calendly if you're interested in one on one mentorship, you could raise search calendly.com/christopher-rangon r a n g o n slash mentorship. In addition to that, feel free to follow me on Instagram and on Tik Tok. Both of my handles are Chris, c h, r i, s, underscore Rangon. R A N, G O N and more for my YouTube channel. Feel free to follow me at skateboard. C R H 12. Yep, I created that account when I was into skateboarding. And I was 12 years old, hence, hence the user name skateboard. CRH 12. **Michael Hingson ** 1:03:16 Cool. Well, Chris, I really am grateful and honored that you came and spent time with us today. And I hope people do reach out to you. And I hope that people will reach out and let us know what they thought of the podcast as well. You can reach me, Michael hingson at M i c h a e l h i at accessibe A C C E S S I B E.com. Or go to our podcast page www dot Michael hingson m i c h a e l. h i n g s o n.com/podcast. Wherever you're listening, please, we really would appreciate it if you would give us a five star rating. We are very grateful for your ratings and your comments. And we would greatly appreciate you doing that for us. We'd love to hear from you. I know Chris would love to hear from you. And we would appreciate both Chris, you and anyone out there listening. If you know of anyone else who we ought to have as a guest on unstoppable mindset, please let us know or email with introductions and we would be very happy to reach out we respond to everything as soon as I see it. So we will definitely respond. But again, Chris, I want to thank you for being here with us. And for all of your time and for all the wisdom that you imparted with us today. We're really grateful for it and thanks again.  **Christopher Hall ** 1:04:42 Thank you so much for having me. Really appreciate it. Michael, thank you.  **Michael Hingson ** 1:04:49 You have been listening to the Unstoppable Mindset podcast. Thanks for dropping by. I hope that you'll join us again next week, and in future weeks for upcoming episodes. To subscribe to our podcast and to learn about upcoming episodes, please visit www dot Michael hingson.com slash podcast. Michael Hingson is spelled m i c h a e l h i n g s o n. While you're on the site., please use the form there to recommend people who we ought to interview in upcoming editions of the show. And also, we ask you and urge you to invite your friends to join us in the future. If you know of any one or any organization needing a speaker for an event, please email me at speaker at Michael hingson.com. I appreciate it very much. To learn more about the concept of blinded by fear, please visit www dot Michael hingson.com forward slash blinded by fear and while you're there, feel free to pick up a copy of my free eBook entitled blinded by fear. The unstoppable mindset podcast is provided by access cast an initiative of accessiBe and is sponsored by accessiBe. Please visit www.accessibe.com . AccessiBe is spelled a c c e s s i b e. There you can learn all about how you can make your website inclusive for all persons with disabilities and how you can help make the internet fully inclusive by 2025. Thanks again

Damian Mckay is a long-time reptile keeper out of Australia and the owner of Copperhead Customs, which is an enclosure design company that specializes in custom-built backgrounds and decor that not only look amazing but are functional and specific to the animal they are made for. In this episode, we cover the fundamentals of building reptile habitats, including enclosure size, basking and heat, hydration, security, and sanitation. We discuss how to design habitats with function in mind, rather than aesthetics. Damian also walks us through the step-by-step process he uses to build backgrounds and much more! SHOW NOTES: https://www.animalsathomenetwork.com/184-cooperhead-customs/ We Discuss: 0:00 Coming Up 2:19 Welcome Damian & Background 20:48 What is Copperhead Customs? 23:07 Habitat Design Essentials 24:06 Understanding Enclosure Size 27:18 Basking & Heat 28:50 Hydration 34:54 Security and Hides 38:59 CRH & Pateron Ad Read 39:50 Sanitation & Ventilation 44:52 Using Natural History to Create a Functional Habitat 1:04:54 Natural Looking but Inappropriate? Using Thermostats 1:16:04 Process for Building Custom Backgrounds 1:37:54 Minimum Enclosure Size 1:53:07 Help New Keepers Start Properly 2:08:13 Bullying within our Community 2:20:07 Damian's YouTube Channel Idea 2:29:57 Closing Thoughts 2:31:10 Outro LINKS FROM THE EPISODE: CHECK OUT Custom Reptile Habitats HERE  https://www.instagram.com/copperhead_customs_/ https://m.facebook.com/CopperheadCustoms3775 https://www.facebook.com/Yarrareptiles https://www.youtube.com/@MillerWilson/videos Support, Subscribe  & Follow: CHECK OUT Custom Reptile Habitats CLICK HERE SUBSCRIBE TO THE PODCAST NETWORK: SPOTIFY► https://spoti.fi/2UG5NOI Support us on Patreon: patreon.com/animalsathome Subscribe on YouTube: https://www.youtube.com/c/AnimalsatHomeChannel Follow on Instagram: @animalsathomeca

This is a special finale episode of the CRH Podcast where Miguel from Teenage Bottlerocket and Porcell from Youth Of Today, Judge and Shelter sit down as their yoga teacher alter egos. I ask them both a variety of questions - some serious, some funny - and they shared great insights and laughs. It was a total blast and I know you'll enjoy it. We chatted about: What yoga means to them Biggest benefits they've gained from yoga Weird yoga stories And more. I mean it's like 2 hours… Connect with Porcell: https://www.instagram.com/thehardcoreyogi/ https://www.instagram.com/youthcrew88/ https://linktr.ee/judgenyhc https://orcd.co/shelter-eternal https://www.instagram.com/valueshere/ Connect with Miguel: https://www.instagram.com/miggy_chen/ https://yogaforpunks.com/ https://www.teenagebottlerocket.com/ __________________________ ❗SPECIAL WELLY P OFFER: Do you love Four Sigmatic? Save 10% with coupon code WELLYP when you shop directly at Four Sigmatic ⁠https://foursigmatic.com/⁠

This is The Delay Dying Blog: Podcast Edition. All essays are written by Amy McBride. Only select essays appear on the podcast. To check out the rest, head over to the website. This essay is about the downsizing of Wellness Provisions. We'll cover... The changes taking place starting now and moving into 2024. The Why behind this decision. Plus some personal insights I've had this year, perhaps prompting you then to look inwards and assess your own life. __________________________ ❗SPECIAL WELLY P OFFER: Do you love Four Sigmatic? Save 10% with coupon code WELLYP when you shop directly at Four Sigmatic ⁠https://foursigmatic.com/⁠

Chaos at OpenAI continues as investors explore legal action against the company's board due to fears over the safety of their investments. Cleo Capital's Sarah Kunst discusses. Plus, Nvidia reports earnings this afternoon, with shares near an all-time high. Decatur Capital's Degas Wright gives his expectations. And, CRH is acquiring a new portfolio of building material assets for more than $2 billion. CRH CEO Albert Manifold explains.

In der heutigen Folge „Alles auf Aktien“ sprechen die Finanzjournalisten Daniel Eckert und Holger Zschäpitz über die plötzliche Champagnerlaune an den Märkten, die Kurshausse bei ProSiebenSat.1 und die abrupte Dollar-Schwäche beim MSCI World. Außerdem geht es um iShares Global Clean Energy (WKN: A0MW0M), Invesco Solar ETF (WKN: A2QQ9R), iShares Core MSCI World (WKN: A0RPWH), Invesco EQQQ Nasdaq-100 (WKN:A2N6RV), ARK Innovation (WKN: A14Y8H), iShares MSCI Global Semiconductors ETF (WKN: A3CVRA). Delivery Hero, Apple, Alphabet, Home Depot, CRH, Berkshire Hathaway, Linde, Eli Lilly, International Flavor & Fragrance, VWWare, Vertiv Holdings, Suncor Energy, Meta, Exxon Mobil, Uranium Energy, Nu Holdings, Helix Energy Solution, TSMC, Avis, Visa, Oracle, Boeing, Canadian National Railway, Thermo Fisher, Block, Fortinet, Booking Holdings, Splunk, Cisco Systems, Microsoft, Horizon Therapeutics, Abcam, Novo Nordisk. Wir freuen uns an Feedback über aaa@welt.de. Disclaimer: Die im Podcast besprochenen Aktien und Fonds stellen keine spezifischen Kauf- oder Anlage-Empfehlungen dar. Die Moderatoren und der Verlag haften nicht für etwaige Verluste, die aufgrund der Umsetzung der Gedanken oder Ideen entstehen. Hier findet ihr alle AAA-Bonus-Episoden bei WELT – dazu den AAA-Newsletter und noch weitere WELTplus-Inhalte: https://www.welt.de/podcasts/alles-auf-aktien/plus247399208/Boersen-Podcast-AAA-Bonus-Folgen-Jede-Woche-noch-mehr-Antworten-auf-Eure-Boersen-Fragen.html Hörtipps: Für alle, die noch mehr wissen wollen: Holger Zschäpitz können Sie jede Woche im Finanz- und Wirtschaftspodcast "Deffner&Zschäpitz" hören. Außerdem bei WELT: Im werktäglichen Podcast „Kick-off Politik - Das bringt der Tag“ geben wir Ihnen im Gespräch mit WELT-Experten die wichtigsten Hintergrundinformationen zu einem politischen Top-Thema des Tages. Mehr auf welt.de/kickoff und überall, wo es Podcasts gibt. +++ Werbung +++ Du möchtest mehr über unsere Werbepartner erfahren? Hier findest du alle Infos & Rabatte! https://linktr.ee/alles_auf_aktien Impressum: https://www.welt.de/services/article7893735/Impressum.html Datenschutz: https://www.welt.de/services/article157550705/Datenschutzerklaerung-WELT-DIGITAL.html

This is The Delay Dying Blog: Podcast Edition. All essays are written by Amy McBride. Only select essays appear on the podcast. To check out the rest, head over to the website. The goal here is to look at the past and heal from it. In this essay we'll cover: How to heal from relationships that lowered your self-esteem How to reshape your own feelings about life, and yourself How to take ownership of your past and love yourself more __________________________ ❗SPECIAL WELLY P OFFER: Do you love Four Sigmatic? Save 10% with coupon code WELLYP when you shop directly at Four Sigmatic ⁠https://foursigmatic.com/⁠

Nick, drummer for Frankie and the Witch Fingers/ Slaughterhouse/ Neighborhood Brats - and talent buyer for Alex's Bar shares how he navigates his busy schedule and keeps himself grounded. With lots of self awareness, Nick also shares areas where he's still improving. This was a very real, raw and relatable conversation. We chatted about: The beauty of touring despite its toll on mental and physical health The importance of self-care Burnout and ways to find balance Self forgiveness Connect with Nick: https://www.instagram.com/nickguyone https://www.frankieandthewitchfingers.com https://linktr.ee/911slaughterhouse https://withkoji.com/@NeighborhoodBrats __________________________ ❗SPECIAL WELLY P OFFER: Do you love Four Sigmatic? Save 10% with coupon code WELLYP when you shop directly at Four Sigmatic ⁠https://foursigmatic.com/⁠

This is The Delay Dying Blog: Podcast Edition. All essays are written by Amy McBride. Only select essays appear on the podcast. To check out the rest, head over to the website. This essay reinforces my thinking that not everything is a diagnosis. You'll either love this episode, or be offended. This applies to you, as well as someone you're pointing a finger at in your life. You're limiting yourself by labeling. It's easy to write someone off with a buzz word that's being thrown around on social media. You don't have to think very hard. But if you took time to look at their actions, or maybe even your own, I think you'd see there are more layers and it's not this black and white buzz word. Humans are complex. __________________________ ❗SPECIAL WELLY P OFFER: Do you love Four Sigmatic? Save 10% with coupon code WELLYP when you shop directly at Four Sigmatic ⁠https://foursigmatic.com/⁠

Marcos, out of Los Angeles, is the mastermind behind his new band, Magnolia. Sonically driven, disciplined and wise beyond his years, Marcos shares how his life experiences have made him a better version of himself. We chatted about: -Solutions for staying calm in life -Awareness and mindfulness -Routine and creativity -How he dealt with and moved beyond substance abuse Connect with Marcos: https://www.instagram.com/marcosvaca_https://www.instagram.com/magnoliaband.wav Magnolia on Spotify: https://open.spotify.com/artist/62TfX6pooiF9N3L9rUl9OJ?si=Miq8LK3ATkCWLcVBkIaE6w __________________________ ❗SPECIAL WELLY P OFFER: Do you love Four Sigmatic? Save 10% with coupon code WELLYP when you shop directly at Four Sigmatic ⁠https://foursigmatic.com/⁠

Get ready for an episode that will change the way you think

Building materials firm CRH and packaging giant Smurfit Kappa are among a growing list of companies seeking to decamp from Europe to US exchanges. In this Viewsroom podcast, Breakingviews columnists discuss what is prompting groups to leave and why the rot is unlikely to ease. Visit the Thomson Reuters Privacy Statement for information on our privacy and data protection practices. You may also visit megaphone.fm/adchoices to opt-out of targeted advertising. Learn more about your ad choices. Visit megaphone.fm/adchoices

David Dudding, manager of the CT Global Focus fund, and newly appointed co-manager Alex Lee, share the fund's investment philosophy of focusing on company-specific factors, competitive advantages, and long-term growth potential. We also consider global economic trends and thematic investment opportunities such as decarbonisation and energy efficiency. David and Alex also discuss the fund's holdings in Apple, Pepsi, CRH, and current opportunities in both Japan and emerging markets. What's covered in this episode: Current sentiment in the global economy, region by regionConcerns about government stimulus in ChinaTrends in machinery and industrialsWhy semiconductor companies have faced challenges recently The fund's approach to stock selectionThe characteristics the managers are looking for in companiesThe investment case for Apple The competitive advantages of CRHPepsiCo: pricing power and snacks Why Japanese companies are looking more attractiveOpportunities in emerging markets, highlighting Indian banksGrowing importance of energy efficiencyMore about the fund: The CT Global Focus fund is a concentrated, high conviction portfolio of best ideas. The fund looks to invest in businesses that demonstrate both exceptional quality and a strong return on investment, with the potential for sustainable long-term growth. Although is truly global fund, the managers only explore opportunities in emerging markets when they meet strict quality criteria. Learn more on fundcalibre.comPlease remember, we've been discussing individual companies to bring investing to life for you. It's not a recommendation to buy or sell. The fund may or may not still hold these companies at the time of listening. Elite Ratings are based on FundCalibre's research methodology and are the opinion of FundCalibre's research team only.Learn more on fundcalibre.comPlease remember, we've been discussing individual companies to bring investing to life for you. It's not a recommendation to buy or sell. The fund may or may not still hold these companies at the time of listening. Elite Ratings are based on FundCalibre's research methodology and are the opinion of FundCalibre's research team only.

This is The Delay Dying Blog: Podcast Edition. All essays are written by Amy McBride. Only select essays appear on the podcast. To check out the rest, head over to the website. Feeling like the world is against you and your dreams are vaporizing into intergalactic dust, never to be seen in full form, again? Then this episode is for you. We'll touch on a few helpful tactics you can employ when you need to persevere and power through. Tip 1 - Connect with your purpose. Tip 2 - Step back and take a break. Tip 3 - Do not accept defeat. __________________________ ❗SPECIAL WELLY P OFFER: Do you love Four Sigmatic? Save 10% with coupon code WELLYP when you shop directly at Four Sigmatic ⁠https://foursigmatic.com/⁠

In this episode we give a business breakdown and share our thoughts about Air Liquide (AI.PA).  Air Liquide plays a crucial role in various industries, including healthcare, manufacturing, and energy. With a global presence spanning over 80 countries, it boasts an extensive network of facilities and research centers. The company's diverse portfolio includes industrial gases, healthcare solutions, hydrogen energy, electronics materials, industrial services, and environmental technologies, aligning with its commitment to sustainability and environmental responsibility through investments in cleaner energy alternatives.  We also look at some of the news of the week around Apple and Mercedes-Benz before answering questions from the community. Lastly, we are thrilled to release our second newsletter where we do a deep dive on British American Tobacco.  Over 30 pages of research so we hope you like it. You can download the newsletter here: https://www.europeandgi.com/inspiration/a-deep-dive-into-british-american-tobacco-newsletter-002/ See you on the inside! Tickers discussed: $AI.PA, $AAPL, $1MBG, $SHELL, $ITX, $LON:SKG, $LON:GLB, $LON:KYGA, $CRH, $NKE, $RTX, $SJM, $K, $PEP

Sean, drummer for Good Riddance, Mad Caddies and Pulley hangs out and talks all things wellness like few others. He is a walking example of PMA and leading a holistic lifestyle and drops so much amazing stuff in this chat. I could have talked to this guy for 6 hours. We chatted about: Nutrition, food sensitivities and detoxing Organic, GMOs and food sourcing Healing from past traumas/pain Exercise and drumming Having a positive mindset Connect with Sean: https://www.instagram.com/seansellersdrummer https://linktr.ee/goodriddance https://www.nextfan.com/links/madcaddies https://linktr.ee/pulleymatters __________________________ ❗SPECIAL WELLY P OFFER: Do you love Four Sigmatic? Save 10% with coupon code WELLYP when you shop directly at Four Sigmatic ⁠https://foursigmatic.com/⁠

This is The Delay Dying Blog: Podcast Edition. All essays are written by Amy McBride. Only select essays appear on the podcast. To check out the rest, head over to the website. This episode is worth the listen if you know someone who has passed, or if you yourself might pass (spoiler alert: you will). In this episode

In der heutigen XXL-Folge „Alles auf Aktien“ sprechen der Tech-Investor Pip Klöckner und Finanzjournalist Holger Zschäpitz über Angst vor einem Dominoeffekt in China, ein Kollaps von Peso und Rubel, ein absurdes Wettbieten um einen amerikanischen Stahlanbieter und die Investments des Meisterspekulanten George Soros. Außerdem geht es um Roundhill Generative AI ETF (ISIN: US88636J6001), Nvidia, Super Micro Computer, Marvell, US Steel, Cleveland-Cliffs, Philips, PayPal, Jinkosolar, Tesla, Lyxor TecDAX ETF (WKN: ETF908), iShares TecDax (WKN: 593397), Kontron, Infineon, Teamviewer, United Internet, Telefonica Deutschland, Carl Zeiss Meditec, Jenoptik, RenaissanceRe Holdings, CRH, GM, Alibaba, Pioneer National Resources, Lennar, Anglo Amercian, Okta, Mobileye, First Horizon, Bowlero, American Water Works, Estee Lauder, Salesforce, Russell 2000 ETF, Freshworks, Netflix, iShares iBoxx $ Investment Grade Corporate Bond ETF (WKN: 779095), Amazon, Google, Rivian, Intuit, Doordash, Fastly, Accenture, iShares iBoxx High Yield Corporate Bond ETF (WKN: A0MP8Z). Wir freuen uns an Feedback über aaa@welt.de. Disclaimer: Die im Podcast besprochenen Aktien und Fonds stellen keine spezifischen Kauf- oder Anlage-Empfehlungen dar. Die Moderatoren und der Verlag haften nicht für etwaige Verluste, die aufgrund der Umsetzung der Gedanken oder Ideen entstehen. Hörtipps: Für alle, die noch mehr wissen wollen: Holger Zschäpitz können Sie jede Woche im Finanz- und Wirtschaftspodcast "Deffner&Zschäpitz" hören. Außerdem bei WELT: Im werktäglichen Podcast „Kick-off Politik - Das bringt der Tag“ geben wir Ihnen im Gespräch mit WELT-Experten die wichtigsten Hintergrundinformationen zu einem politischen Top-Thema des Tages. Mehr auf welt.de/kickoff und überall, wo es Podcasts gibt. +++ Werbung +++ Du möchtest mehr über unsere Werbepartner erfahren? Hier findest du alle Infos & Rabatte! https://linktr.ee/alles_auf_aktien Impressum: https://www.welt.de/services/article7893735/Impressum.html Datenschutz: https://www.welt.de/services/article157550705/Datenschutzerklaerung-WELT-DIGITAL.html

With cement giant CRH shifting its primary listing to the New York stock exchange and noises that gambling group Flutter could soon follow suit, the Irish stock exchange is facing significant challenges.Will there be moves to make the domestic stock exchange easier to join? Perhaps a vibrant junior exchange could provide a solution?Ciaran Hancock gets the thoughts of Current Affairs Editor with the Irish Times, Arthur Beesley and CEO of Cantor Fitzgerald Ireland, Ronan Reid.And Irish Times Senior Business Reporter, Barry O'Halloran takes us through his story on how Ticketmaster Ireland has been offering GAA county boards cash incentives to sign up or renew contracts. Hosted on Acast. See acast.com/privacy for more information.

Rikki, drummer for Death Valley Girls, hangs out at her cabin in the woods and talks all things wellness, sharing great insights into how to care for yourself holistically. We chat about: -Nature stuff -Managing anxiety -Building self-trust and confidence -Aging and health Connect with Rikki: https://www.instagram.com/rikkistyxx https://www.instagram.com/deathvalleygirls https://linktr.ee/deathvalleygirls Photo Credit: Chris Barber __________________________ ❗SPECIAL WELLY P OFFER: Do you love Four Sigmatic? Save 10% with coupon code WELLYP when you shop directly at Four Sigmatic ⁠https://foursigmatic.com/⁠

This is The Delay Dying Blog: Podcast Edition. All essays are written by Amy McBride. Only select essays appear on the podcast. To check out the rest, head over to the website. In this episode, we're going to dig into my feelings about this business and podcast. This essay is going to be both a little bitter, and a little sweet on the palate. Parts cooked, parts raw. Because sometimes I feel up against a wall with Welly P. So we're going to jump into what I mean by that. Here is my brutal truth of how I feel about Wellness Provisions. __________________________ ❗SPECIAL WELLY P OFFER: Do you love Four Sigmatic? Save 10% with coupon code WELLYP when you shop directly at Four Sigmatic ⁠⁠https://foursigmatic.com/⁠⁠

Mike, punk drummer and owner of a bitchin' Airbnb in Joshua Tree, sits down and shares how he stays healthy and happy with such a demanding schedule. We also go on a tangent about nutrition and food and it's pretty hilarious. We chatted about: Touring with health in mind Rest VS Productivity Discipline and staying organized Dealing with adversity Connect with Mike: https://www.instagram.com/mikebystereo/ https://linktr.ee/deathbystereoband https://www.instagram.com/theadolescentsusa/ https://adolescents.shop/ Photo Credit: Christian Thomas __________________________ ❗SPECIAL WELLY P OFFER: Do you love Four Sigmatic? Save 10% with coupon code WELLYP when you shop directly at Four Sigmatic ⁠https://foursigmatic.com/⁠

S3 Bonus Episode | June The multitalented Blag Dahlia, frontman and mastermind of the Dwarves, sits down and talks all things writing. If you aren't privy to his books, seek them out. I love his writing style and this conversation covers a lot of ground. We chatted about: How his storytelling differs from songs vs novels Writing as catharsis Pushing through writer's block Tons more. Just tune in! We also talked about: Decent Criminal https://linktr.ee/DecentCriminal Connect with Blag: https://www.instagram.com/thedwarves/ https://www.instagram.com/blag_dahlia/ https://thedwarves.com/ __________________________ ❗SPECIAL WELLY P OFFER: Do you love Four Sigmatic? Save 10% with coupon code WELLYP when you shop directly at Four Sigmatic ⁠https://foursigmatic.com/⁠

John Lee is the CEO and Founder of Work From Anywhere and a serial entrepreneur. John describes his experiences living and working in multiple countries and the complexities of intercultural communication across large multinational organizations. He discusses the opportunities and issues for employers who seek to offer employees options to work remotely internationally and increase their international hiring, which his company helps with. John shares his expectations about the Future of Work and the advantages for employers of accessing a broader talent pool.   KEY TAKEAWAYS   [02:48] John studies accountancy — the “language of business” — to support his desire to become an entrepreneur.   [03:50] John was inspired to create something bigger than himself and leave an imprint for the better.   [05:00] John develops his natural language gift.   [05:45] John explains how learning other languages enables deeper human connection.   [6:10] John picks his worst skill to work on in college which propels him internationally at Deloitte.   [07:10] How John's language skills are useful working on performance improvement initiatives around Europe.   [07:35] Plant managers share many more issues when communicated with in their own language.   [08:20] John built strong relationships and learned much about the international businesses thanks to his communications and cultural sensibilities.   [08:55] A transition moment to leave the corporate world, catalyzed by John's mentor.   [09:18] John's wife, Dee, conceives of the first business concept focused on intercultural training.   [10:12] They launch a travel well-being community to foster and share travel related soft skills.   [11:20] John and his wife noticed their Lonely Planet guide didn't share information about countries' cultures and people.   [12:14] Intercultural research was a core resource integrated to offer culturally-focused local videos and information.   [13:12] CultureMee wins a prestigious award for best business travel technology product.   [14:36] Dutch and Irish cultural differences had interesting repercussions when John worked at CRH.   [16:28] A yes/no Bulgarian example of communication differences!   [17:18] John has a deep curiosity about people, their cultural and other identities.   [18:20] The shift from studying national differences to encompass diversity, inclusion, and more.   [19:14] Pivoting to a business travel API, they have major growth opportunities in the US.   [20:00] The pandemic hits at the worst moment—John takes time off to regroup.   [21:55] What is the No 1 obstacle preventing internationally distributed working for millions of people?   [22:50] What is the right solution for your next international remote hire?   [23:51] Companies are exploring distributed work: temporarily working in different countries and structurally hire people in different jurisdictions.   [25:00] Key reasons include accessing a deeper talent pool or getting closer to customers.   [26:45] Cities are assessing the visitors they attract—from cruise passengers to digital nomads.   [29:45] Digital nomad visas—which had gaps initially—are accelerating the future of international remote work.   [30:39] Local economies benefit by encouraging new visitor types.   [31:16] The second accelerating factor is the “employer of record” arrangement.   [32:00] How businesses can expand internationally easily using new options.   [33:43] John on the recent partnership with Mercer.   [34:38] Some companies are adjusting better than others to new working options. John feels we are still working it out.   [36:25] John's own preferences, perceived benefits, and balance.   [38:31] What are the implications for income tax?   [39:24] What will the impact be on traditional education systems?   [40:00] John is intrigued by Plumia, a venture trying to create a country on the Internet!   [42:02] IMMEDIATE ACTION TIP: If your company is interested in offering international remote working options, review useful white papers for benchmarks about global mobility, chat with a tax or immigration provider, and a good employment lawyer about new international working models.   RESOURCES   John Lee on LinkedIn Work From Anywhere SIETAR Europa Running Remote   QUOTES (edited)   “A lot of the talks I'd been to from entrepreneurs, those that didn't have a finance background said they felt it held them back. They kind of described accountancy as the language of business.”   “I loved the fact that when you speak in somebody's language, you connect with them on a much deeper level.”   “I was at the 10-year-point in my career and I still had a burning desire to be an entrepreneur. My mentor at the time said to me, ‘John, you have a great career here, but if you do want to become an entrepreneur, do it now. You can always come back but if you stay here for another five or 10 years, you're gonna become institutionalized. It'll be much harder.'”   “The Dutch tended to discuss things democratically but were very direct in their communication. Whereas, Irish people tended to decide hierarchically, but were indirect in how they communicated. And what ended up happening was there was a lot of intercultural friction because you'd have some misinterpretation.”   “And so that's what we've built with Work From Anywhere, a platform that automates the ‘how.' It tells you what the risks are. It tells you if you can or cannot do remote.”   “In Barbados, a year after they launched digital nomad visas, they had over a hundred million generators for the local economy. You can imagine they had a huge drop off in cruise passengers because of COVID-19. So obviously, launching this helped mitigate the shortfall from cruise passengers.”

This is The Delay Dying Blog: Podcast Edition. All essays are written by Amy McBride. Only select essays appear on the podcast. To check out the rest, head over to the website. In this episode, we're going to go on a journey and look at how shifting your perspective can impact your future (and present). Can your relationship to money change? Do you want life to feel easier? Find out what changes can help. __________________________ ❗SPECIAL WELLY P OFFER: Do you love Four Sigmatic? Save 10% with coupon code WELLYP when you shop directly at Four Sigmatic ⁠https://foursigmatic.com/⁠

We started the show by talking about $SHELL capital markets presentation. We discuss our current thoughts on the company, including recent dividend hikes and buybacks. We also ponder if we will ever sell a company like Shell from our portfolios. Dividend Hikes covered this week are from $TGT, $CAT,$O, $EPT For the main topic, we discuss both two companies we are currently buying.  Derek is buying $VICI and $CRH, and EDGI is buying $AMS:ASR and $HPQ. We finish, as always, by answering questions from our amazing community, where we are asked about companies such as $MMM, $KO, $CCOI, and $MFC. Links mentioned in the show TheDividendGuy check out his videos: https://youtu.be/yKa42DyUcOQ  Join the conversation on Facebook: Dividend Talk group (facebook.com)

Linh, bassist of Bad Cop Bad Cop, shares some truths and reflects on all the different elements that help us become better versions of ourselves. We chat about: Healthy boundaries Perfectionism  Beauty and imperfections Self-talk and self-kindness How she balances her stress levels Connect with Linh: Photo Credit: Tony Smith @tonysmith_images __________________________ ❗SPECIAL WELLY P OFFER: Do you love Four Sigmatic? Save 10% with coupon code WELLYP when you shop directly at Four Sigmatic ⁠https://foursigmatic.com/⁠

We started today's episode with Apple's ($AAPL) exciting news around its launch of “Vision Pro” - VR / AR glasses with a whopping 3500 USD price tag.  In part two of the news of the week, EDGI talks about the French finance minister who helped to strong-arm big food companies into cutting prices. The companies, which together make 80% of what the French people eat, could face financial sanctions if they don't follow through. Unilever (LON: ULVR) is one company in our portfolio who are affected by this pledge and we discuss our thoughts. There is only one dividend hike of note which is $UNH For The main topic, we talk about how we would invest €10k. Before we list our tickers we start by discussing lump sum investing vs euro cost averaging. We talk a little about the reasoning behind the companies we choose and such as a forward PE ratio of not more than 20, a payout ratio below 60% if possible, and an average yield of about 3%. Of course, there are some exceptions as quality can come at a price.Tickers mentioned are $VICI, $CRH ,$TROW,$CCOI,$BTI, $SBUX, $TXN, $MSFT,$JNJ, AMS:AD, $ALV, $SHELL, EPA:MC, BIT:CRP, BIT:RACE, BIT:ENEL,$TGT, $GME, $ENB, $TTE BME:ENG, $MCD , $TSN, ETR:VNA, CPH: NOVO-B, SWX: SREN, $IIPR, $NKE, $HEL: KESKOB Finally, we answered 23 questions from the community such as: If you were wanting to impress your father-in-law with your best dividend growth stock pick to date, which one would it be? (And why?). How do you work out the dividend yield of a whole portfolio? At what interest rate would you consider putting money in your savings account instead of investing it? On Trading212, what's your opinion about the share lending feature?  How's your Walgreens position looking? Links mentioned in the show TheDividendGuy just sold all his $ENB shares, check out his video: https://youtu.be/yKa42DyUcOQ  Jeremy from Dividend Stockpile just wrote a post about it and also posted on our Facebook group. - https://dividendstockpile.com/ugi-corporation-deep-dive/ Join the conversation on Facebook: Dividend Talk group (facebook.com)

Noradrenaline (norepinephrine) is a neurotransmitter and hormone that plays a role in the body's "fight or flight" response.  Acetylcholine is a neurotransmitter (“brain” +” across” + “to send”) that helps transmit signals in the brain and body. Its name comes from its chemical structure, an acetate group and a choline molecule.  Dopamine is a neurotransmitter that plays a role in motivation, reward, and movement. Its name comes from its chemical structure, a combination of two molecules called dihydroxyphenylalanine and dopamine. Adrenaline (epinephrine) is a hormone and neurotransmitter that helps the body respond to stress. Its name comes from its source, the adrenal glands.  Serotonin is a neurotransmitter that is involved in mood, appetite, and sleep. Its name comes from its chemical structure, a combination of sero- (meaning "serum") and -tonin (meaning "tonic" or "substance that modifies").  Corticotropin-releasing hormone (CRH) is a hormone that stimulates the release of cortisol, a stress hormone. The name comes from its function of stimulating the release of corticotropin, a hormone that stimulates the adrenal glands. Also, it gets its name from its role in stimulating the release of adrenocorticotropic hormone (ACTH) from the pituitary gland, which in turn stimulates the release of cortisol from the adrenal gland. Vasopressin is a hormone that regulates water balance in the body. Its name comes from its ability to constrict blood vessels (vasoconstriction) and increase blood pressure. Vasopressin, also known as antidiuretic hormone (ADH), is so named because it regulates water balance by causing the kidneys to reabsorb water. Thyrotropin-releasing hormone (TRH) is a hormone that stimulates the release of thyroid-stimulating hormone (TSH), which regulates the thyroid gland. Its name comes from its function of stimulating the release of thyrotropin.  Oxytocin is a hormone that is involved in social bonding, childbirth, and lactation. Its name comes from its ability to stimulate uterine contractions (oxytocic) and milk ejection (lactogenic).  Gonadotropin-releasing hormone (GnRH) is a hormone that stimulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which regulate the reproductive system. Its name comes from its function of stimulating the release of gonadotropins.  Growth hormone–releasing hormone (GHRH) is a hormone that stimulates the release of growth hormone (GH), which regulates growth and metabolism. Its name comes from its function of stimulating the release of growth hormone.  Catecholamines are a group of hormones and neurotransmitters that includes adrenaline, noradrenaline, and dopamine. Their name comes from their chemical structure, which includes a catechol group and an amine group.  Histamine is a neurotransmitter and hormone that is involved in inflammation, allergies, and gastric acid secretion. ACTH (adrenocorticotropic hormone) is a hormone that stimulates the release of cortisol from the adrenal glands.  Orexin (hypocretin) is a neurotransmitter that is involved in wakefulness and appetite. Its name comes from its discovery in the hypothalamus and its ability to stimulate food intake (orexigenic).  Glutamic acid (glutamate) is a neurotransmitter that is involved in learning, memory, and neural plasticity. Its name comes from its chemical structure, a combination of glutamine and an acid group.  Galanin is a neuropeptide that is involved in pain perception, mood, and appetite. Its name comes from its discovery in the galanin-containing neurons of the hypothalamus.  Neurotensin comes from the words "neuro," meaning related to nerves, and "tensin," which refers to its ability to cause contraction in smooth muscle. Neurotensin is a neuropeptide that is found in the central nervous system and gastrointestinal tract. --- Support this podcast: https://podcasters.spotify.com/pod/show/liam-connerly/support

durée : 00:59:26 - Entendez-vous l'éco ? - par : Tiphaine de Rocquigny - 20, c'est le pourcentage de femmes qui dirigent une entreprise de plus de dix salariés aujourd'hui en France, selon les chiffres de l'Insee en 2019. Un patron sur cinq est donc une femme. Ce constat serait-il la continuité d'une réalité historique ? - invités : Nicole Dufournaud Chercheuse en histoire, membre associée du Centre de recherches historiques (CRH) de l'EHESS, ingénieure de recherche dans le cadre du projet “Cité des dames, créatrices dans la cité”de l'Université Gustave Eiffel ; Camille Dejardin historienne de formation et autrice de “Madame Blakey, une femme entrepreneure au XVIIIe siècle” (2019) aux Presses Universitaires de Rennes et de “Patronnes au XVIIIe siècle” aux éditions du Nouveau Monde en février 2023

Hey! this week in the last of my metallurgy series I chat about Alloys and how to detect them what to look out for and comment that everything is really just an alloy and how we don't want ferrous AlloysHowever, before we start I want to thank you for listening to the podcast and I hope you enjoy the episode this week  If you want to support the show there are many options available from the links in the episode notes below and if you want to interact with me and the show that information is there too.but most importantly If you like this content please don't hesitate to tell your friends and don't forget to hit that subscribe button.Support the showThanks for listening. You can contact and support the show using the following link.YoutubeContact:VoicemailTwitterInstagramDr DetectorCiaranSupport:PatreonBuymeaCoffee

Hey everyone this week we chat about metal detecting in an urban environment where to go and how to set your detector up for this often disregarded environment plus we have a question for the Dr from Shaggy about GPS and Appropriate GPS apps for metal detecting.However, before we start I want to thank you for listening to the podcast and I hope you enjoy the episode this week  If you want to support the show there are many options available from the links in the episode notes below and if you want to interact with me and the show that information is there too.but most importantly If you like this content please don't hesitate to tell your friends and don't forget to hit that subscribe button.Support the showThanks for listening. You can contact and support the show using the following link.YoutubeContact:VoicemailTwitterInstagramDr DetectorCiaranSupport:PatreonBuymeaCoffee

The US will launch a renewed crackdown on countries that are helping the Kremlin evade western sanctions, the world's largest building materials group plans to move its listing from London to New York, and the FT's Delphine Strauss explains why higher wages could undermine central banks' battle against inflation. Mentioned in this podcast:US to launch new crackdown on Russian sanctions bustingBuildings giant CRH plans to move listing from London to New YorkGlobal economy: will higher wages prolong inflation?Download the FT Edit app here: ft.com/fteditThe FT News Briefing is produced by Fiona Symon, Sonja Hutson and Marc Filippino. The show's editor is Jess Smith. Additional help by Peter Barber, Michael Lello, David da Silva and Gavin Kallmann. Topher Forhecz is the FT's executive producer. The FT's global head of audio is Cheryl Brumley. The show's theme song is by Metaphor Music. Read a transcript of this episode on FT.com Hosted on Acast. See acast.com/privacy for more information.

In this episode, Piers and I unpack the headline 'Fears for the future of the London Stock Exchange' as SoftBank and the world's largest building materials group CRH, shunned the City in favour of New York.We look at where London sits in the context of the global exchanges, what makes New York more attractive and what can the UK government do to stop what has been a gradual decline of the UK's influence over the past 170 years.Free daily newsletter https://bit.ly/3Oeu4WkFree Finance Accelerator simulation https://bit.ly/3GoyV5rConnect with Anthony https://www.linkedin.com/in/anthonycheung10/Connect with Piers https://www.linkedin.com/in/pierscurran/ Hosted on Acast. See acast.com/privacy for more information.