Podcasts about glutamate

After working with property management business owners for over a decade, I've realized that the problems they are experiencing tend to be deeper than issues in the business… In this episode of the #DoorGrowShow, property management growth expert Jason Hull sits down with Sam Womack to discuss entrepreneurship, health, and how the two intertwine. You'll Learn [01:57] How stress affects your health [13:48] The impact of oxygen and proper relaxation [17:40] The importance of being able to calm your nervous system [26:10] More health expert insights   Tweetables “Everybody's doing the best they can with their current limited access to knowledge and resources.” “Don't beat yourself up for when you feel stressed out. Just make sure that before you continue that stress rollercoaster, like find some space to find some peace.” “You don't have to like beat all your competitors in a lot of instances, you just need to outlive them. You just need to outlast them.” “High performance isn't just how hard you push. It's about how well you recover and regulate.” Resources DoorGrow and Scale Mastermind DoorGrow Academy DoorGrow on YouTube DoorGrowClub DoorGrowLive TalkRoute Referral Link Transcript [00:00:00] Sam: If you don't find time to balance your nervous system or don't work on implementing tools to balance your nervous system, then you are limiting yourself to lower performance in the short term and decreasing performance in the long term.  [00:00:15] Jason: Welcome DoorGrow property managers to the Property Management Growth Show. If you are a property management entrepreneur that wants to add doors, make a difference, increase revenue, help others, impact lives, and you're interested in growing in business and life, and you're open to doing things a bit differently, then you are a DoorGrow property manager. [00:00:37] Jason: So DoorGrow property managers love the opportunities, daily variety, unique challenges, and freedom that property management brings. Many in real estate think you're crazy for doing it. You think they're crazy for not because you realize that property management is the ultimate high trust gateway to real estate deals, relationships, and residual income. At DoorGrow, we are on a mission to transform property management business owners and their businesses. We want to transform the industry, eliminate the BS, build awareness, change perception, expand the market, and help the best property management entrepreneurs win. I'm your host, property management growth expert, Jason Hull, the founder and CEO of DoorGrow. [00:01:21] Jason: Now let's get into the show. Cool.  [00:01:24] Jason: And I'm hanging out here with sam Womack. Sam, welcome to the show.  [00:01:29] Sam: Thanks for having me on. I'm excited to be here.  [00:01:31] Jason: Cool. So Sam we met at a local mastermind here in the Austin area, which is really cool. And for those that know that I run a mastermind for property managers, I also eat my own dog food and believe in getting coaching and learning and growth and everything else. [00:01:52] Jason: And wanted to connect with some people locally and make some friends as well. So, Sam's one of those friends. So, Sam, welcome to the show. And why don't you give people a little bit of background on yourself and what you do and how you kind of. Got into running businesses and doing cool stuff. [00:02:10] Sam: Yeah, no, thank you. First off, I don't do anything near as difficult as you guys. Managing property and tenants, I think is a feat to be held. And so props to all you guys out there crushing it in real estate. I cut my teeth in entrepreneurship starting at a young age. I was charging like 30 bucks an hour to teach old people how to use their computers, you know, tell their life story. [00:02:29] Sam: They'd pay me 30 bucks an hour while they sat there and henpecked. It was pretty ingenious. Fast forward into later on in life when the pandemic hit the business that I was launching just disappeared overnight. The retail died, everything that I've been working on, all the investors pulled out. [00:02:44] Sam: I was left with a few grand in my name and a baby on the way, living in a studio apartment with my wife. Had to figure something out, went into supply distribution, and a couple years later, fast forward, I did about 20 million in revenue as a solopreneur distributing gloves, masks, COVID test kits, etc. [00:03:01] Sam: But throughout that time, I dealt with like a really serious health issue. Stress had kind of overwhelmed me and I ended up with an autoimmune condition in my brain and through the journey of healing that autoimmune condition that was presenting as like early onset Alzheimer's, it was kind of a mystery. [00:03:16] Sam: They didn't know what was happening. I developed a deep passion for finding the root of health and the root of optimization and root of performance. A lot of that came through working with my mom, who's a preeminent physician focusing on anti aging and regenerative science here in Austin. [00:03:31] Sam: And so I typed her handwritten notes for a couple years and followed the patient journeys of the elite because she has a concierge practice for the elite here in Austin. And as I saw what drove change in their lives, I learned a lot about the human psyche and I learned a lot about how each of our individual unique biologies are very different when it comes to what we choose to do to find optimization or find optimal health. And so now I have a passion for bringing that to the masses. And as the pandemic waned, and as I healed, I became passionate about different physics based modalities and the different systems in the body and how to reach optimal performance. [00:04:07] Sam: And now I have a wellness center here in Austin that focuses on performance optimization, as well as maximizing human potential and transitioning the human experience as well as a research Institute called Human Beaming Research Institute, where we present the stories of the truth about health and where we help bring true health science to light so that people understand what's actually true, not truth that's manufactured by special interests, but truth that's founded in science. [00:04:36] Jason: Got it. Yeah. I mean, there's kind of a battle right now, right? We're like seeing it all play out live real time. Oh yeah. Got this whole make America healthy movement. We've got RFK, Bobby like and it seems like there's some major disruptions that are kind of happening right now and there's a battle and we're waking up. [00:04:58] Jason: A lot of people are waking up that hey, you know, big food, big pharma, you know, big government are not in favor of us being healthy for some reason, which is kind of scary. So yes, yeah kind of waking up to this and I don't know, maybe we're all biohackers now. I don't know.  [00:05:17] Sam: Yeah. No, I you're absolutely right I think that humanity as a whole is kind of done drinking the Kool Aid when it comes to what we've been told is the truth. [00:05:27] Sam: And, you know — [00:05:29] Jason: Yeah. Cause the Kool Aid has like glyphosate in it and like, also like molds and mycotoxins, like it's got bad stuff all over it. And I'm not saying actual Kool Aid. This is metaphorical people. Metaphorically.  [00:05:42] Sam: Yes. And when you look at like where, you know, just briefly to when you follow the money and you see that, like, from a business standpoint, one of the largest mergers and acquisitions in history, if you bring it to current dollar value was when big tobacco bought the food industry and you look at when that transition happened and you see what happened to our food supply and you know, we're fish in a barrel that they're just taking their pick of right now when it comes to what we have that's societally acceptable to put in our bodies and societally acceptable to engage in, in terms of social interaction, et cetera. [00:06:15] Sam: And it, yeah. Kind of funnels us down this path of high stress, which kind of takes us to today's topic with the nervous system. But yeah, I don't don't know if you have anything else you want to discuss before we dive in.  [00:06:25] Jason: Well, I want to point out. So Sam really sharp guy, as you can tell already, Sam's going to be a speaker at our DoorGrow Live conference. [00:06:35] Jason: And he's going to talk about some really cool stuff that we're very holistic at DoorGrow. And so I know that in coaching entrepreneurs and having talked to thousands of property management business owners and coaching hundreds of clients that it's never really the business or that they're spending too little time in their business that's keeping them from succeeding in business. It's everything else, especially health, especially their relationships, especially their marriage. Like these things create a lot of friction for entrepreneurs And they've got a lot going on. You're not really talking about property management when you come to DoorGrow Live, but I do believe it will be a game changer for them to be able to perform more, be able to get more out of their business, be able to get more out of life, which is the goal of having a business, right? [00:07:20] Jason: That's more freedom and more fulfillment. So, yeah. So if you have not yet gone to doorgrowlive.Com and gotten your tickets. Go do that right now. Go get your tickets and make sure you're at that event. Come hang out with us in North Austin at round rock at the Kalahari resort. It's going to be awesome. [00:07:36] Jason: All right. Shameless plug completed. Now, Sam, let's get into talking about the topic at hand.  [00:07:43] Sam: Yeah, I know. And thank you. And I'm really excited to get on stage and speak and I'm going to save some nuggets for the stage. Won't give it all the way here. So I'm really excited about that and helping you guys understand what the true root of your full potential actually is and not from some woo woo space, but actually understanding like the fundamental simple science beneath high performance and beneath fulfillment in life because it really does break down to a very simple equation. One of the key factors is a molecule, and that molecule is actually oxygen. [00:08:13] Sam: And when your brain is in a high stress state you would think that your body would give it more oxygen under high stress, right? But under high stress, you actually have vasoconstriction. Your blood pressure rises, blood gets pumped to your extremities, you got to get away from that proverbial bear, right? [00:08:29] Sam: But for y'all, that bear is the constant wave of tenant complaints, the constant wave of, you know, economic factors interest rate shifting stuff like that And so you have this like constant bear chasing you and if you're always in that state of fight or flight your brain is patterned to operate on survival mechanisms and a lower amount of oxygen and so And then we get this like male, sometimes male and female, but we get this, like this almost masculine energy of like, let's go conquer and do this high stress, high action push, push, push coffee, stimulant. [00:09:03] Sam: And we're really performing with our hands tied behind our back at that point, because our brain has less oxygen in it. And when you look at the other side of the nervous system, which is our parasympathetic nervous system you have this increase of oxygen in the brain. which actually raises serotonin instead of relying on that dopamine cortisol roller coaster, right? [00:09:24] Sam: And so, at the base of this is oxygen, which is bringing us life, which is creating ATP, cellular energy. And, to put it simply, If you don't find time to balance your nervous system or don't work on implementing tools to balance your nervous system, then you are limiting yourself to lower performance in the short term and decreasing performance in the long term. [00:09:48] Sam: Higher relying on stimulants, higher amounts of of just stress and cortisol and dopamine reliance in the long term, which takes away from your ability to connect with others, to find community, to find that real fulfillment that comes in life.  [00:10:02] Jason: And so what you're saying is we shouldn't just overdose on coffee that here in the U. S. probably has mold in it and makes you not feel good and have to pee way too much. And then not, you know, take care of ourselves in breathing effectively and getting too little sleep, too much hustle, too much stress.  [00:10:23] Sam: Yeah.  [00:10:24] Jason: Okay.  [00:10:24] Sam: Yeah, we can get addicted to that pattern because stress actually can feel really good. [00:10:30] Sam: When you have dopamine augmenting that cortisol, right? Without dopamine, cortisol feels really crappy. You know, you look at high anxiety. You look at that restlessness feeling where you don't feel good. You're on edge. That's when your cortisol's high and your dopamine is kind of low because you've been exhausting the dopamine stores by just pushing it. [00:10:50] Sam: Dopamine is supposed to be a short term reward to get us out of the stress back into a parasympathetic state. Dopamine was never meant to be the consistent ongoing reward. Because, like, think about it for survival, right? If you're, you know, trying to get away from the bear, and you're running, that needs to somewhat feel good, in order to get you through that stress. [00:11:11] Sam: So dopamine kicks in when oxygen lowers in the brain. And then, when you get out of the stress, you find that parasympathetic state again, you calm down, oxygen rises in the brain, serotonin rises, which is that more deeper, long term fulfilling chemical, that actually leads to creativity as well. But our society tells us that love is dopamine. It tells us that success is dopamine. It tells us achievement is dopamine. It gives us these dopamine triggers for all of the cultural hierarchy and the cultural validation, that external validation when you do something to succeed and you show it off, that's a dopamine trigger. Social media is a trigger. So all of these things, society is structured in a way that says, "dopamine's the reward. Now go buy shit, right?" Like almost all the financial economy is driven surrounding dopamine, which is a ultimate losing game because you guys all know that it doesn't really provide that end fulfillment, but since it feels good, we're kind of stuck in that loop. And so. What I want to help illuminate is where true fulfillment can be found and help with some kind of practical tools and a practical understanding of this foundational science so that when you're looking to perform at your best, you can give yourself a break and allow yourself to relax. [00:12:22] Sam: You know, before you have that next cup of coffee to keep yourself going, take some deep breaths, find some space to relax. Don't worry that your brain doesn't feel a hundred percent on. And give yourself some space to allow that peace in knowing that you're raising oxygen in the brain. You're opening oxygenation to areas that are going to drive creativity, that are going to allow for connection, that are going to allow for more presence in your body. [00:12:44] Sam: You'll be a different person in the home. You'll be a different person towards yourself. And so these are critical components of understanding the power of the nervous system when it relates to performance. Because high performance isn't just how hard you push. It's about how well you recover and regulate, and it's about how you create that balance that pushes for longevity and pushes for long term endurance and strength. [00:13:09] Sam: Because if you want to succeed and grow your business 5x, 10x, 100x, you need endurance. Sympathetic, nervous system tone, high stress does not create endurance. It's short term bursts, you crash out or you keep hitting the stimulants. And it keeps you in this narrow window of potential. You find that parasympathetic, you find that relaxation, you get creativity going in your brain, you get higher oxygenation in your brain, you're shifting gene expression towards longevity. [00:13:33] Sam: So it's a pretty powerful tool. And most people think, "oh, I don't want to meditate, you know, or I don't want to relax", or they don't feel safe when they're calm. And it's something to just work on shifting your perspective on because there's true power in that state of peace.  [00:13:48] Jason: A while back, I read this book. [00:13:50] Jason: I don't know if you heard of this. It's called the Oxygen Advantage. It's by a guy named Patrick Mckeown and it's got a forward by Dr. Joseph Mercola, but it's interesting because basically the book is about how he trains athletes to breathe through their nose while working out instead of their mouth, which like exercises the lungs and increases lung capacity. [00:14:15] Jason: But if they're, if we're constantly operating with our mouth open and working with our mouth open, we actually decrease our lung capacity. And so, athletes are just burning out really quickly and they don't have the ability or the capacity to, you know, absorb as much oxygen. So like working out those muscles, like breathing through your nose, you know, is something that talks about, but that's interesting that when we're not calm, we're not getting enough oxygen that we're not recovering, we're not regulating our stress, our body probably starts to eat itself a little bit and, you know, and then we get addicted to dopamine and you know, in business, most businesses fail and really you don't have to like beat all your competitors in a lot of instances, you just need to outlive them. You just need to outlast them. And that, that endurance aspect. And so I think, you know, I think we're going to go through some financial turmoil in the marketplace. Things are probably going to get worse before it gets better as we're cleaning up all this mess financially that is going on in the government. [00:15:18] Jason: And the U S dollar is like, I think it's been going down from its original value down and down as they've been stripping value out of it through inflation and giving that money to who knows who. And so. I think there's going to be a big transition. It's going to get really stressful. [00:15:33] Jason: And I think the businesses that are just able to last through this transition and endure and they're focused on the long game are the ones that are going to win.  [00:15:43] Sam: Absolutely.  [00:15:44] Jason: And there's going to be a lot just eaten up.  [00:15:46] Sam: Yeah. And if you don't allow that perspective of what you just explained about business to apply to your own self and your health, you know, what got you here won't get you there. [00:15:54] Sam: And if you want to sustain and succeed through the turmoil, then you need to adapt. And when you have a high stress state, you actually lose BDNF expression in the brain brain neurotropic factor and brain derived neurotropic factor. And that is our adaptability aspect and factor in our brain. And it literally decreases its efficiency, the higher, the more chronically stressed we are. [00:16:18] Sam: And so it's super important. You guys can look up BDNF and understand its role with oxygenation in the brain. And so fundamentally, you know, the more oxygenated your brain is, the greater your access to intuition, memory, and high level thinking. And those are key components to succeeding in business. [00:16:33] Sam: And when you are in a state of constant survival mode, constant reactivity, constant push, hustle, you lose that space to develop creative longterm solutions. You lose that space to be able to get that spark of inspiration on how to pivot around the corner and see around that corner or do something a little differently than what other people are doing. [00:16:55] Sam: And that's why even you look at like Thomas Edison, Benjamin Franklin, like they would love to access that like state estate, the theta state just akin to sleep. They would put like a lead ball in their hand over a metal plate. And then as they were falling asleep. It would drop and the ball would hit the metal plate wake them up and they'd have their pen and their quill and ink on the table with a candle and then they'd have their formula or problems they were trying to solve and then they'd go to solving it because that was deep parasympathetic state where that creativity was opened up brain oxygenation was opened up. And me, just like so many of y'all out there, like, I'm like, man, I do not like meditating, I do not like calming down, like slowing down.  [00:17:31] Jason: I mean, especially if we're addicted to dopamine and adrenaline, like slowing down feels like a waste of time.  [00:17:39] Sam: Oh yeah, it does. And so you, most of you have heard of dopamine, serotonin, and adrenaline slash norepinephrine, right? That's only 20 percent of our neurotransmitters. [00:17:51] Sam: Okay. What's the other 80 percent glutamate and GABA, right? Glutamate is the exitory neurotransmitter. So that's what animates our body. Think glutamate animate, but then GABA is what balances that. So GABA helps slow things down, shut things down. And it's kind of interesting that popular culture slash society, like you don't hear much about GABA. [00:18:13] Sam: And the reason why is because they're selling us GABA in the form of alcohol. Alcohol is a huge GABA receptor connector, so it just hits the GABA and you feel kind of calm and relaxed. And so people love alcohol to be social because you want to be in a slight more parasympathetic state to be social, right? [00:18:30] Sam: Because high stress doesn't lead to—  [00:18:32] Jason: What about scrolling on social media?  [00:18:33] Sam: Social media is going to be hitting dopamine, not so much the GABA. But scrolling social media is going to be giving dopamine, new information. Ooh, new information. I learned something new, like boom, like that constant external input stimulus. [00:18:45] Sam: But when you look at the importance of GABA and you understand that a lot of us aren't making it on our own, which is why we're staying in such a high stress state all day. Yeah. And then we take a GABAergic, like GABA or a benzo or some weed or something that, that can hit that, that GABA receptor instead of making our own endogenous GABA. [00:19:02] Sam: And that's what happens when you're in a parasympathetic state is your body is creating its own GABA to balance out the brain. And that's what drove me to developing a suite of tools called Peace on Demand that I have at my wellness center that are physics based modalities that drop you into that parasympathetic state without sitting there fighting against your brain and trying to force yourself to meditate. [00:19:21] Sam: And then also with hyperbaric oxygen therapy, that's another tool that induces a parasympathetic state over the course of the treatment. And so I found tools because my brain, I had a hard time controlling with the autoimmune disease that I had and how stressed and on fire my brain was, I had a lot of difficulty finding that space, but without those tools, you can still utilize things like breath work, even if it's just longer exhale than the time you're inhaling or like four seconds in, you know, hold for a little bit and then eight seconds out or seven seconds out. [00:19:48] Sam: That, that's just like the simplest form of breath work to kind of activate the vagus nerve and slow down that that nervous system and get you into a more parasympathetic state but it's really interesting when you see that some of the most creative people and the most successful people, they're not super high strung. At a certain point, you'll see a lot of successful people that are high strung. Push, push hustle. [00:20:10] Sam: But then you go to that next level. You look at like the Elon's of the world, or, you know, so these people are on that next level. You watch them speak. They're calm. They have this, you know, they go hype on at times to like reach certain goal. But then they also have that balance. So the key is balance. [00:20:26] Sam: Don't beat yourself up for when you feel stressed out. Just make sure that before you continue that stress rollercoaster, like find some space to find some peace, do some breathing, take a pause, give yourself that chance to take a break. That'll start developing some resiliency in your nervous system so that you don't burn out. [00:20:42] Jason: Yeah, it does seem like really high performers are highly adaptable to, you know, situations. So they move and adapt quickly. It seems like they are able to maintain some calm, but they also are really quick thinkers, like their thinking seems to be faster than normal. I notice for me, I get really frustrated with team members when they're not— [00:21:05] Jason: I'm like, "come on, this is super quick. Like, look how fast I can do this." And I'm like, "keep up." And so that becomes a little bit of a frustration. I'm like, why is everybody slow? I saw this really interesting thing. My son sent me this and he's really into football. And I guess there's some quarterbacks that are now training with VR. [00:21:23] Jason: Playing the game in VR and but they're doing it at 1. 5 speed. And so they're getting used to everything being fast and they've adapted to that. So then when they go and play, it feels like everything's in slow motion. And I was like, wait a sec. I listen to telegram messages at two speed. I listened to audio books at two, between 1.8 to two speed. Like, so my brain is probably more adapted to speed.  [00:21:49] Sam: Yes.  [00:21:50] Jason: And and so I'm able to process, I was just hanging out with somebody who has a lot more money than me, who runs, who's the CEO of Real, Sharran Srivatsaa. And he talks really fast and he thinks really fast. Like this guy is sharp. [00:22:03] Jason: And I'm like, how does he move so fast? You know? But also and he doesn't seem like stressed out or anything. One of the things I've noticed, maybe like sparks this GABA sort of thing is just for me, reading? Just reading, actually reading not like high speed audiobooks, but sitting down with a book and processing information, my body's in a calm state. I feel a really deep calm where I'm in a flow sort of state reading and absorbing and processing information. So I found that can be a really good tool for me. [00:22:34] Jason: Sarah and I go do your peace on demand thing, which is just awesome. And a game changer. It's really been helpful for Sarah. It's kind of, I compare it to doing a float session, having a really good float session which doesn't happen every time you do a float session, but it happens every time you do Peace on Demand and you don't have to get wet and naked, and nothing gets in your eyes or ears on accident sometimes and stings. [00:22:54] Jason: So that's nice. The other thing I've noticed is just walking. So I went and did EMDR therapy for a while, for like a year with a therapist, bilateral stimulation, both sides of the brain is the concept. And then I noticed like, well, walking is bilateral stimulation. And so that's like a free, very cheap version of EMDR therapy is just to go on walks. [00:23:14] Jason: And rather than running, which is like, Hey, stress response. I found walking is very calming, especially if I'm really stressed. If I go for a walk, it kind of signals to my body, "Hey, you're okay. You're not being chased by a saber tooth tiger right now." So your fight or flight, calm down. So those are the things that work for me. [00:23:32] Jason: I don't know, but those are great tools. I don't know.  [00:23:35] Sam: Yeah. So what those are doing are like, you mentioned a keyword there and that's safe, right? And so you're creating these environments. One, you're reading a book, gaining new knowledge, and you're not cramming the book in a stressed out state to try to memorize it for a test, right? Which so much of us get programmed in school at an early age, that like reading means like, focus hard and stress out over what you're reading. [00:23:56] Sam: But if you allow yourself to relax into that flow state, and you mentioned flow state as well, flow doesn't happen when you're in super high stress state. Some people We'll try to say, "Oh yeah, I'm in flow" because they've got like dopamine coursing and cortisol coursing and  [00:24:10] Jason: they're like manic and going crazy.  [00:24:12] Sam: Yeah, exactly. [00:24:13] Jason: They're busy, but they're not productive.  [00:24:15] Sam: Yeah. And when you get productive and when you feel like you're going fast and your team isn't responding fast enough, like you have that adaptability, you have that BDNF that's really efficient in your brain because you practice going in and out of these states and you spend a lot of time in this flow and in this GABA balanced state Where you're not hyper stressed out and one one thing that also on a biochemistry level explains some of this is: in a sympathetic nervous system response, your body is trying to find as much glucose as possible to burn glucose for fast quick energy, which creates oxidative stress on the body, which creates inflammation. And then your body has to like go clear out all the junk but it doesn't care that it's creating a bunch of junk to clear out, because it's trying to help you survive short term. [00:24:59] Sam: When you're in a parasympathetic state, you're looking at a—  [00:25:02] Jason: Does it make you crave sugar then?  [00:25:03] Sam: Yeah, so high stress makes you crave sugar. Whereas parasympathetic state, you're on a more fat burning metabolism. You're not creating as much oxidative stress. You're like expressing longevity genes. You're expressing anti inflammatory genes. [00:25:16] Sam: Your body literally shifts into almost a different state, not just mentally, but biophysically and biochemistry wise all throughout your body. You adapt based on the nervous system state that you allow. And that's where it does come down to personal responsibility to make the choice to start practicing finding this state that will empower so much more potential for your life than that narrow band of, you know, survival programming and high stress thinking. [00:25:46] Sam: And then it's better for your health longterm too, because you're not just compounding oxidative stress nonstop and then needing those negative inflammatory inputs to make your dopamine stay high. And you can just find that peace. And then you'll find a much higher level of performance and that flow state will start just happening naturally constantly, which is what's been happening for Jason as he's been practicing these things as well. [00:26:08] Jason: Got it. Okay. Very cool. So little teaser, what are you going to talk about a little bit at DoorGrow Live that will be revelatory or helpful for people that might be a little bit stressed in their business or are wanting to take their performance to the next level? And I just, I want to point out, the difference I've noticed just in clients doing time studies and things like this. [00:26:32] Jason: Some of my clients will, we can see in their time study that they, it takes them in the latter half of the day, like the afternoon, an hour to do stuff that takes them 10 minutes in the morning. They're just, they're running out of brain chemicals. They're running out of like, what are neurotransmitter chemicals that they produce while sleeping? [00:26:51] Jason: They're now no longer productive and efficient, even though they're working really hard and they're really busy. And so, so yeah, maybe you could tease a little bit. What could we talk about there that might optimize their productivity so that they could actually feel superhuman and get two to three times the amount of output with the same amount of work or stress or effort? [00:27:14] Sam: Yeah, so we're going to go into a little bit more detail on some other aspects of the foundations of performance. So today we focused on nervous system, which is key. But. Controlling our nervous system isn't just as easy as thinking about it. There's some environmental factors. There's some lifestyle choices we can make. Often, we have a really hard time making those changes due to the, those well worn grooves, like, you know, skis on a slope that are really hard to get out of. And so I'm going to help with some simple truths that you'll understand and make it a lot easier to start making small shifts that will create massive change and that don't have to be stressful or induce anxiety or feel hard. It'll actually feel easy. So I'm going to help you understand some fundamental truths about your biology and That will unlock unlimited potential.  [00:28:03] Jason: Yeah, because I think every entrepreneur listening, myself included, I'm sure you as well, have been in those time periods where you feel like you're working so hard and you're investing so much time and energy, and you're going nowhere like it feels like you're just treading water and you're burning yourself out and you're like, "why am I not adding hundreds of doors? Why am I not growing my business? Why am I not getting ahead? Why am I seeing idiots get further along than me?" You know, like, " why is this not working for me?" And and I think that all plays into that like that. Everything you're talking about plays into that.  [00:28:41] Sam: You'll find yourself having permission to make some changes and the permission is a key aspect of that courage and that bravery to choose something different to focus on something different. [00:28:56] Sam: I mean, we all hear where you, where your attention goes, your focus grows, you know, and what you focus on is what you create, you know, all these things. What does that fundamentally and literally mean when it comes to the way we choose our life experience? And what can we create when our choices change and how can we be empowered to make those choices? [00:29:16] Sam: Those are some of the more intricate topics that we'll discuss.  [00:29:19] Jason: Got it. Almost like shifting from feeling like, "Hey, I'm giving up something or sacrificing in some way that in actuality, you're getting more."  [00:29:30] Sam: Oh, so much more. Exactly. So much more. Yeah. Cool.  [00:29:34] Jason: So. Those of you listening, I'm guessing you're growth oriented, growth minded. [00:29:39] Jason: You want to get more. Come to DoorGrow Live. Come hear Sam talk. So cool. Sam, appreciate you coming here on the #DoorGrowShow. If people are hanging out in Austin or curious about what you're up to, how can they find you? Peace on Demand. Tell them about your stuff and how people might be able to follow you or get in touch. [00:29:58] Sam: Yeah. So we have a small wellness center here. It's a private, you know, high touch concierge space, very comfortable here in Austin. And it's open for business by appointment only but just go to beamhyperbarics.Com and you can book an appointment. If you want to reach out to me I am Sam Womack. [00:30:15] Sam: On Instagram or you can send a message through the website. Easier website to remember is beam.do B E A M dot D O. And yeah, just reach out, come hang out. You don't even have to buy something to come in. Just hit me up. We'll make sure that I'm around and we can sit on the couch in the back and talk life. [00:30:34] Jason: All right. Awesome, Sam. Appreciate you coming on and excited to have you at DoorGrow Live.  [00:30:40] Sam: Yeah. I'm excited as well. Looking forward to it. I love what you're doing. And I think the steps that you're taking to help empower people beyond just showing them tactics and strategies, but helping them live a more fulfilled and empowered life. [00:30:50] Sam: That's what it's all about. So thank you for that work you're doing.  [00:30:53] Jason: Yeah, absolutely. We've just noticed like we can give them all the right tactics and strategies, but if they don't incorporate the other things, it's kind of like you're trying to run a race up the mountain with rocks in your backpack, like boulders, you know, it's just, it's so much more efficient if we get everything else in alignment and usually it's never the business piece that's really what's holding them back. It's not the tactics it's mindset. It's their mental health. It's like everything else, their family. Yeah. So we're excited to bring you and some others that are going to just unlock a lot of things for our clients and for non clients that are coming to DoorGrow Live. [00:31:32] Jason: So appreciate you.  [00:31:34] Sam: Yeah, you bet. Thank you. And just one last thing is you guys are all doing such a great job too. Like, don't think of this as any type of a criticism or, "Oh, you're not doing good enough." Like you're doing such an excellent job with the tools that you were programmed with the upbringings you had with the environment you're in. [00:31:48] Sam: So like, just look at it as a chance to learn something new and be empowered by it. But you guys are all doing such a great job. And so keep it up.  [00:31:56] Jason: Yeah, everybody's doing the best they can with their current limited access to knowledge and resources that they put out. Whatever. All right, cool. Awesome, Sam. I'll let you go. All right. So, if you are a property management entrepreneur and you're wanting to add doors or increase your profit or lower your stress, reach out to us at DoorGrow we would love to help you grow and scale your business. You can check us out at DoorGrow. com. And if you're wanting to join our free community, get a little bit more info about us, hang out with some other property managers, go to DoorGrow club. com to join our free community and connect with other property managers and get some cool free stuff. And until next time to our mutual growth, everybody. Hope you all crush it. Bye everyone. [00:32:38] Jason: You just listened to the DoorGrowShow We are building a community of the savviest property management entrepreneurs on the planet in the DoorGrowClub Join your fellow DoorGrow Hackers at doorgrowclub.com Listen everyone is doing the same stuff SEO PPC pay-per-lead content social direct mail and they still struggle to grow at DoorGrow We solve your biggest challenge getting deals and growing your business Find out more at doorgrow.com Find any show notes or links from today's episode on our blog doorgrow.com and to get notified of future events and news subscribe to our newsletter at doorgrow.com/subscribe until next time take what you learn and start DoorGrow hacking your business and your life.

OCD, or Obsessive Compulsive Disorder, is a debilitating condition that involves intrusive thoughts and time-consuming, repetitive behaviors. It impacts 80 million worldwide, 2-4% of the US population or 1 in 100 people here in the US.It can be difficult to overstate the suffering caused by OCD, not only for those with this condition but also for their family members. In addition to the distress caused by the obsessional thoughts and compulsions, there can be shame and loss - loss of more meaningful, purposeful, or pleasant thoughts and behaviors. and loss of time connecting with others or engaging in purposeful or enjoyable activities.Other conditions associated with obsessive-compulsive disorder include:* Body dysmorphic disorder* Skin picking* Trichotillomania (hair pulling)* Hoarding* Hypochondria* Olfactory reference syndrome (an irrational feeling or belief that one emits a foul smell and often attempts to remove the odor).It´s not unusual for someone with OCD to have other conditions, such as:* Other forms of anxiety* Depression* ADHD* Autism spectrum disorder* Eating disorders* TourettesResearch suggests that having OCD raises one´s vulnerability to developing dementia. Many other brain conditions, however, also appear to increase this vulnerability similarly.Treatment ChallengesOCD is particularly challenging to treat. Of those with OCD, 60% do not respond to typical therapies (often medication in combination with psychotherapy involving gradual exposure to that which is being avoided). Typical medications include:* SSRI´s (Selective Serotonin Reuptake Inhibitors) -e.g., sertraline, fluoxetine, fluvoxamine, citalopram, paroxetine* Tricyclic antidepressant - clomipramine* SNRI - (Serotonin and Norepinephrine Reuptake Inhibitor) - venlafaxine* Atypical antipsychotic medications are sometimes addedMedication is combined with CBT (Cognitive Behavioral Therapy), which involves exposure and response prevention, or CBT is used alone.As you can see, most medication approaches aim to increase serotonin activity. Serotonin, however, is just one of the neurotransmitters involved. What has become increasingly clear from the research is that OCD involves abnormal activity at the NMDA receptor - a glutamate receptor.NMDA & GlutamateThe NMDA receptor is found throughout the brain. Glutamate, the primary excitatory neurotransmitter in the central nervous system, binds to the NMDA receptor. NMDA and glutamate are involved in synaptic plasticity (creating neuronal connections), learning, memory, and motor function.The synapse is the space between communicating neurons. Presynaptic neurons release glutamate, which binds to the NMDA receptor on postsynaptic neurons. This results in a cascade of signaling events that lead to “neuronal excitation.” The problem arises when this receptor has too much (or too little) activity. In the case of OCD, there is too much activity.Implications* Dysregulation at the NMDA receptor appears to play a role in OCD, depression, PTSD, schizophrenia, bipolar disorder, and substance use disorders.* Weak memory extinction can result from high activity at the NMDA receptor. While memory is a good thing, we can have problems with too much memory - or rather, problems putting our memories aside. This can look like thoughts getting stuck, for example:* Intrusive thoughts in OCD* Flashbacks in PTSD* Delusions in psychotic disorders* Cravings in addiction.* Neurodegenerative disorders, such as Alzheimer's, Parkinson's, and ALS, have also been linked to NMDA receptor malfunction.Methylation & NMDAThose who are undermethylated, especially those with OCD or addictions, have high activity at the NMDA receptor. To remind you, undermethylation is a biochemical process with many functions, including the breakdown of histamine, support of detoxification, and support of serotonin activity. When someone is undermethylated, they can tend to have allergies (from high histamine), be perfectionistic, competitive, strong-willed, have obsessive-compulsive tendencies, be ritualistic, have dietary inflexibility, and have high accomplishment or have family members with high accomplishment. Undermethylation can contribute to the low serotonin activity seen in OCD. Simply addressing undermethylation, like merely addressing serotonin, will only bring partial benefit. To address undermethylation, those of us trained by the Walsh Research Institute, use SAMe and/or methionine, B12, B6, magnesium, and antioxidants. We address this before starting methylation treatment for those with high homocysteine. But how can we also decrease activity at the NMDA receptor?Blocking NMDA & Normalizing Glutamate ActivityEsketamine or Ketamine, which has been getting much attention in recent years, can impact the brain in various ways; however, its primary mechanism is as an NMDA blocker or antagonist. For some, it can serve as a rapid-acting and highly effective antidepressant. It can also decrease OCD symptoms. Other NMDA-blocking drugs include memantine and dextromethorphan (combined with bupropion). Lamotrigine can decrease glutamate release and has been used as an adjunct medication for OCD.Nutrients, however, play an important role in the NMDA receptor. NAC or N-acetyl cysteine is a precursor to glutathione and, thus, an antioxidant. It is also anti-inflammatory and a binder for a particular toxin made by candida and mold. But, it is also a potent NMDA antagonist (decreases activity at NMDA) and has been shown to reduce obsessions and compulsions of OCD. It has also been studied in alcoholism, opiate addiction, cocaine abuse, gambling disorder, shopping disorder, cigarette addiction, and trichotillomania. It has been used by itself and as an adjunct to medication therapy. NAC has become part of the Walsh undermethylation nutrient protocols for those with OCD and/or addiction.Zinc also plays an important role in regulating functioning at the NMDA receptor. The Walsh Research Institute found that 90% of those with brain symptoms had relatively low zinc. Dosing of zinc is determined after testing plasma zinc levels using a narrow range (the Walsh/Pheiffer range differs from typical lab ranges). Zinc is checked in conjunction with copper. Zinc has been found to improve treatment response in those with OCD treated with SSRIs. Zinc can be depleted because of very high oxidative stress and/or high pyrroles, which also cause low B6. Because B6 is needed to make serotonin, pyrroles are also important to address if elevated.Inositol is a nutrient involved in the serotonin and glutamate signaling systems. It, too, is beneficial for OCD symptoms; however, it can require very high doses.The challenge of research, as you can see, is that these approaches are all looked at in isolation, as opposed to, for example, addressing undermethylation, optimizing zinc, decreasing activity at the NMDA and addressing sources of oxidative stress.Candida & MoldAside from undermethylation, low serotonin activity, and high activity at the NMDA receptor, those with OCD appear to have high oxidative stress, as is the case with most brain-related conditions. One of the more common sources of oxidative stress I see in my practice is candida overgrowth in the GI tract, which often follows antibiotic exposure and /or mold toxicity due to water damage causing seen or unseen toxic mold. Because mold and candida (yeast) thrive on sugar and a high-carb diet, symptoms can fluctuate with sugar or carb intake. How might candida and mold intersect with the NMDA receptor? Mold and yeast can contribute to high histamine states. Histamine can increase activity at the NMDA receptor. EstrogenFor women and teen girls that I see with OCD, there is often a fluctuation in their OCD symptoms with their cycle. Typically, their symptoms worsen during the times of the month when estrogen is the highest. This may be because estrogen can increase activity at the NMDA receptor.PANDAS & PANSWhen a child has an abrupt onset of OCD symptoms, PANDAS and PANS should be considered.* PANDAS = Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections* PANS = Pediatric Acute-Onset Neuropsychiatric SyndromePANDAS and PANS are autoimmune conditions, meaning the immune system is acting on the body, in this case, a part of the brain called the basal ganglia, that involves an acute onset of OCD symptoms. Other symptoms can include restricted eating, mood symptoms, regression in academic or social skills, and motor tics. While triggers are often viral, bacterial (strep in the case of PANDAS), candida,or other microbial source, what is underlying the dysregulated immune response to such microbes, in my experience, is mold toxicity. SummaryBecause OCD can be difficult to treat, my hope in sharing this information is to raise awareness that effective OCD treatments can require a multifaceted approach that includes:* addressing methylation (and high pyrroles if present) to improve serotonin activity* decreasing activity at the NMDA receptor* by optimizing zinc* using supplements or medication* addressing sources of inflammation and high histamine* address sources of oxidative stress - trauma, stress, toxins, inflammation If you find this information helpful and would like to help me get this out into the world, please consider sharing:As always, I welcome your comments, questions, and experience.Until next time,CourtneyP.S. To learn more about non-patient consultations, treatment, and monthly mentorship groups, please visit my website at:CourtneySnyderMD.comMedical Disclaimer:This newsletter and podcast episode is for educational purposes and not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment for yourself or others, including but not limited to patients you are treating (if you are a practitioner). Consult your physician for any medical issues that you may be having. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit courtneysnydermd.substack.com/subscribe

This podcast covers the metabolism of alanine, aspartate, and glutamatr in the disposal of nitrogen and the Urea cycle. Also covered are the roles of alanine transaminase, aspartate transaminase and glutamate dehydrogenase.

Send us a text- On-Demand Programme Link - https://mailchi.mp/bb2a7b851246/kairos-centreThere is a correlation between Sex Addiction and ADHD. When faced with 'danger' on a daily basis (even whilst in the womb!), healthy brain development is derailed and impeded. The area in the brain called the Amygdala (the smoke alarm for danger), increase in volume and becomes over activated.The Pre-Cortex and Hippocampus becomes compromised. The protective behaviours become 'hard wired'. Lifestyle, nutrition, exposure to toxins and stress, all play a part in activating ADHD genes. Let's have a brief chat about 'The Pleasure Principle' - of the brain. Pleasure has a distinct signature in the brain. Dopamine release in the Nucleus Accumbens is tied to Pleasure. It is the brain's 'Pleasure Centre'.Sex Addiction behaviours cause a powerful surge of Dopamine into the Nucleus Accumbens. Those addictive hormones/drugs, provide a shortcut to the brain's reward system - as it floods the Nucleus Accumbens. That shortcut is lush.The Hippocampus lays down the memory marker as to how this rapid sense of satisfaction is achieved. The Amygdala creates a conditioned response to such stimuli. Dopamine interacts with another neurotransmitter (called Glutamate) to take over the brain's system of 'Reward-related' learning.That system is important in linking activities for human survival.Addictive substances and behaviours stimulate the same circuit, then overloads it. Over time, the brain adapts in a way that makes the 'sought-after' substance or activity, to be less pleasurable.The hunt is on to find more novelty, newness, risk taking and crossing boundaries.Try this article by Dr Anna Lembke - "Resetting your brain's Dopamine balance": https://youtu.be/azcVRy1X4FsLet the Kairos Centre come alongside you to reclaim your quality of living life - without shame - bringing colour back to life.Give a little to my fund raising page here, to help someone access the Recovery Programme: https://igg.me/at/ThekairosCentreWant to know more? Click the link and come get me.Get the help you need: bit.ly/pornaddictionhelpDiscover the real, authentic you - without shame.The Kairos Centre created one of the world's first comprehensive Online Webinar Sex, Porn, Love Addiction video-on-demand Recovery Programme; discover the real, authentic you. www.kairos-centre.com or email info@kairos-centre.comNow launched: A Video-on-Demand Online Course (for Singles, Couples/Marrieds/Partners) Access here - https://www.kairos-centre.com/changement-on-demand/Gary McFarlane (BA, LLM, Dip, Certs), Accredited EMDR Practitioner.Episode Keywords: Sex Addiction | Porn Addiction | Love Addiction | Root Causes | Brain Impact | Self-Soothing Behaviors | Family Conflict | Emotional Neglect | Peer Pressure | Performance Pressure | Separation | Divorce | Fear | Anxiety | Stress | Pain | Dissociation| Recovery Program | EMDR Therapy | Emotional Event | Trauma Healing | Neuroplasticity | Online Therapy | Sex Addiction Recovery Program | Compulsive Behaviors | Intimacy Issues | Sexual Dysfunction | Obsessive Thoughts | Guilt | Infidelity | Traumatic Bonding | Objectification | Hypersexualization | Pornography Industry | Love Addiction Patterns | Attachment Styles | Sexual Compulsivity | Behavioral Therapy |

Welcome back to our weekend Cabral HouseCall shows! This is where we answer our community's wellness, weight loss, and anti-aging questions to help people get back on track! Check out today's questions:    Audrey: Hello! Appreciate all of your insight - you are a wealth of knowledge! I'm a 32 year old that has had idiopathic thrombocytopenia since I had my child 5 years ago. Just wondering what labs you recommend for this and how to improve the numbers. Thanks!     Kaylee:  Hi Dr. Cabral. I appreciate everything that you do. I'm reaching out because I am at a loss for what to do next. I have dealt with chronic constipation and bloating my entire life. A year ago I cut out all dairy from my diet and started working with an IHP. She was phenomenal and for a while, constipation, gas, and bloating had subsided while working with her. Through working together I am now able to have a bowel movement every morning. However, the intense bloating, gas and belching has returned. From the moment I wake up until I go to bed, my stomach gets more and more distended as the day goes on. I prioritize Whole Foods, still don't eat dairy, exercise five days a week, prioritize 7 to 8 hours of sleep at night and live a healthier life than a lot of my peers. What should I do?     Kelsey: How does glutamate affect methylation?     Frances: Hi doctor Cabral, First off, I just want to say how amazing you are at breaking down complex health topics and offering practical solutions on your podcast. It's been incredibly helpful, and I truly appreciate it. I have a question about raw vs. cooked vegetables. Traditional Chinese Medicine and Ayurveda often recommend eating cooked vegetables to aid digestion and other bodily processes. Does this also apply to veggies we add to smoothies? I frequently use raw spinach, kale, and cauliflower in mine. Should I be cooking them first, or does blending them make them easier to digest? Thanks so much for your answer. Frances     Lauren: Hi Dr. Cabral, a close friend is suffering from Morton's Neuroma in both her feet. She has had cortisone injections, tried rest & really can't find much in terms of natural remedies. Are you able to make any suggestions? Sometimes surgery is the only option but I would appreciate your expertise/guidance on possible healing modalities? Thank you!     Thank you for tuning into today's Cabral HouseCall and be sure to check back tomorrow where we answer more of our community's questions!      - - - Show Notes and Resources: StephenCabral.com/3228 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

Heißhunger ist der plötzliche und unkontrollierbare Drang, schnell etwas zu essen – oft begleitet von der Begierde nach Süßem, Salzigem oder Fettigem. Das sind dann die Momente, in denen man zu viel isst und danach ein schlechtes Gewissen bekommt, weil man das eigentlich so nicht wollte.

This podcast covers the catabolism of alanine, glutamate and aspartate, including the roles of 3 important enzymes alanine transaminase (ALT), aspartate transaminase (AST) and glutamate dehydrogenage in this process. Input of nitrogen into the Urea cycle is provided directly or indirectly through the metabolism of the 3 discussed amino acids.

In an insightful interview conducted by LowCarbUSA® co-founder Pam Devine, Dr. Georgia Ede, MD, shared profound insights from her new book, "Change Your Diet, Change Your Mind," and highlighted the significance of metabolic psychiatry. Dr. Ede, a Harvard-trained psychiatrist with extensive experience in nutrition, brain metabolism, and mental health, will be a key presenter at the upcoming LowCarbUSA 9th Annual San Diego Symposium for Metabolic Health, taking place from August 15-18, 2024. Pam Devine expressed her excitement about her participation, recalling their first collaboration in 2017. Dr. Ede emphasized the unique atmosphere of the LowCarbUSA® conferences, describing them as "science for the people." She praised the efforts of Doug Reynolds and Pam Devine in creating a warm and welcoming environment. According to Dr. Ede, "Every conference has a different feel, and this particular conference has a really nice down-to-earth, people-focused feel. It's science for the people." Join Us at the Symposium in San Diego, August 15-18 This podcast episode is just a glimpse of the comprehensive, science-backed health insights Dr. Ede will share at the 9th Annual San Diego Symposium for Metabolic Health, August 15-18. Don't miss this opportunity to gain invaluable knowledge and interact with leading experts in metabolic health. This year's symposium will feature a full day, Thursday, August 15th, dedicated to exploring the connection between mental health and metabolic disease. Focus on Metabolic Psychiatry One standout feature of this year's conference is the dedication of an entire day to metabolic psychiatry on August 15th. Dr. Ede noted the explosion of research in the field and the quantum leap it represents for psychiatry. "The brain matters," she stated, highlighting developments in treating mental health conditions through metabolic interventions. Addressing the limitations of conventional psychiatry, she remarked, "We have not been thinking about root causes. Metabolic psychiatry looks at the metabolic root causes, the drivers, the underlying forces that are damaging and destabilizing the brain." She pointed out that the traditional approach of treating mental health conditions as lifelong chemical imbalances requiring medication is being challenged by new findings in metabolic psychiatry. Debunking Dietary Myths Dr. Ede debunked common dietary myths, such as the belief that oatmeal is a brain-healthy breakfast. She shared a case from her book where a physician's blood sugar spiked dangerously after consuming oatmeal, underscoring the need for a fundamental shift in dietary recommendations. "If you want real change to your mental health, you need to fundamentally restructure your diet from the ground up in ways that make biological sense," she stated. "Base your diet on science, not wishful thinking and wild guesses." Importance of Nutrient-Rich Foods She emphasized the importance of nutrient-rich foods that provide the essential building blocks for brain health. "The brain needs nutrients. All food is about parts and energy. We need the right parts to build cells, including brain cells, and we need to fuel those cells sustainably." Essential nutrients include amino acids, fats, vitamins, and minerals, which are often lacking in typical modern diets. "Most of what we're eating now is not nourishing or energizing our brain properly. In fact, it's damaging the brain," she added. One major culprit in this dietary crisis is the widespread consumption of vegetable oils. "Vegetable oils are extraordinarily high in Omega-6 fatty acid called linoleic acid," she noted. "Over the past 60 years, our intake of linoleic acid has increased significantly, and it's accumulating in our body fat and brain, causing oxidative stress and inflammation." This leads to brain damage over time. She highlighted the importance of choosing foods that support brain health by providing necessary nutrients without causing harmful spikes in blood sugar and insulin levels. She asserted, "Animal-based foods, rich in essential nutrients and low in carbohydrates, are key to this approach." Dr. Ede also discussed the concept of "quiet diets" featured in her book, which include variations like quiet paleo, quiet keto, and quiet carnivore diets. These diets emphasize low-carbohydrate and ketogenic principles to reduce metabolic stress on the brain. "The more sugary your diet is, the harder it can become for your brain to use that sugar for energy," she explained. This can lead to insulin resistance, making it difficult for the brain to process glucose effectively. Balancing Brain Chemistry She expanded on this, explaining how the brain processes glucose and the critical role of insulin. "The brain doesn't need insulin to let the glucose in; it needs insulin to process the glucose once it comes in," she explained. Without adequate insulin, the brain, despite being flooded with glucose, cannot utilize it effectively, leading to a paradoxical situation where the brain is both overwhelmed with glucose and starving for energy. This disruption in brain chemistry can lead to severe mental health issues. "If you want to balance your brain chemistry, one of the most effective ways to do that is to unbalance your diet," she stated. Lowering carbohydrate intake, particularly to ketogenic levels, can significantly improve brain function by stabilizing glucose and insulin levels and providing ketones as an alternative energy source. Dr. Ede also discussed the balance between glutamate and GABA, the brain's primary neurotransmitters. "Glutamate is the gas pedal, and GABA is the brake pedal," she explained. The balance between these neurotransmitters determines the brain's activity level, and eating refined carbohydrates and vegetable oils can profoundly disrupt this balance, leading to overstimulation and mental health issues. "If you're eating these refined carbohydrates and vegetable oils, you're getting all this inflammation and oxidative stress," she said. "The inflammation and oxidative stress throw this system profoundly out of balance." The interview concluded with Pam Devine highlighting the importance of attending the LowCarbUSA Symposium in person. Dr. Ede echoed this sentiment, emphasizing the unique benefits of in-person conferences. "It's a completely different experience," she said. "You'll meet other people, make lasting connections, and leave feeling energized and more knowledgeable." She encouraged people to take advantage of this opportunity to learn from experts and immerse themselves in the latest research on metabolic health.

What is flavor? Neil deGrasse Tyson and co-hosts Chuck Nice and Gary O'Reilly explore the science of what makes some foods tastier than others, what is “umami,” and how flavor changed in the 20th century with food scientist Arielle Johnson.NOTE: StarTalk+ Patrons can listen to this entire episode commercial-free here:https://startalkmedia.com/show/the-science-of-flavor-with-arielle-johnson/Thanks to our Patrons Lisa Pulkrabek, David Guilbault, TheRealErikEvans, Daniel Jones, Joshua Troke, Chris Hampton, Shaun Grossman, Pete Evans, Chris Love, and andrea nasi for supporting us this week.

References Guerra, DJ. 2024. Manuscripts in preparation. Paganini , N. 1819. Violin Concerto No 1. Op6. https://youtu.be/e52mkjorLAY?si=YhamClbb9LkUWOGf Hunter-Garcia. 1972. "US Blues" Grateful Dead https://youtu.be/cr-iGxbALnc?si=ImRdGq0Evh03vUd2 Miller, S. 1968. "Livin' in the USA" https://youtu.be/6Hv6WXSt7vs?si=JLdzYmlWuyRp8uIm Simon, P. 1968. "America" https://youtu.be/Eo2ZsAOlvEM?si=ahFS-qll3oKvw-bl --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

About the Guest(s): Dr. Kristin Hieshetter is a highly respected figure in the realm of functional health, demonstrated extensively through her dedication to educating others about the significance of comprehensive healthcare. Although her full professional history is not discussed, it is clear from the transcript that she is passionate about helping people understand their health better. Dr. Hieshetter appears to be knowledgeable about topics like excitotoxins and their impact on the human body, advocating for natural and preventative approaches to health. Episode Summary: In the latest enlightening episode of Functional Health Radio, Dr. Kristin Hieshetter dives deep into the startling downward trend of life expectancy in the United States and the rising chronic diseases among children. Initiating the conversation with disturbing healthcare statistics, she pivots to discuss the overlooked dangers of excitotoxins in our diet, linking them to neurodegenerative diseases. The episode is rich with alarming yet vital information, balancing medical insights with actionable health tips. Dr. Hieshetter references the worrying trend of decreasing life expectancy in the U.S. and contrasts it with the exorbitant healthcare spending, posing the question of what can be done differently. She introduces Dr. Russell Blaylock's research on excitotoxins, pulling lessons from historical examples such as the Chamorro Indians of Guam to underscore the dangers of dietary neurotoxins like glutamate and aspartate. The episode artfully blends anecdotes with science to underline the proposition that current dietary habits could pose a risk to neurological health, emphasizing the importance of magnesium and antioxidants for brain protection. Key Takeaways: U.S. life expectancy has fallen, and chronic diseases in children are at unprecedented rates, suggesting an urgent need for a healthcare paradigm shift. Excitotoxins like glutamate can build up to toxic levels in the brain, with prolonged exposure leading to devastating neurological diseases. Early exposure to excitotoxins has been linked to neurodegeneration, even decades later, elevating the importance of cutting these toxins from our diets. Dietary antioxidants and nutrients such as vitamin C, E, glutathione, magnesium, and omega-3 fatty acids are emphasized as crucial for brain health and protection. The role of excitotoxins in neurodegenerative conditions and the pivotal importance of dietary changes for prevention and recovery are central themes. Notable Quotes: "We are walking around in the most amazing, intelligent, responsive, adapting, and aware system in the world, the human body." "Excitotoxins can sometimes be linked to those disease processes in the body." "The clinical symptoms of most neurodegenerative diseases don't show up until 80% to 90% of specific cells in the spinal cord or specific regions of the brain are dead or damaged." "Magnesium is your brain's most powerful protector." "Eat your fresh fruits and vegetables, they're critical for your survival." Resources: The resources mentioned include: Dr. Russell Blaylock's book "Excitotoxins: The Taste That Kills" Studies cited by Dr. Kristin Hieshetter: The works of scientists George Spencer, Leonard Kerland, and more from the 1950s to 1980s on the Chamorro Indians and excitotoxins. Functional Health Mastery For a comprehensive understanding of the ways to protect your brain from excitotoxins and the power of a natural diet, listen to the full episode. Don't forget to tune in to Functional Health Radio for more discussions that can revolutionize your approach to health and well-being.

Joined again by the fabulous Ellie to discuss her trauma journey, and how the body recalls and resurfaces trauma responses. We delve into myofascial release, GABA, Glutamate, synaptic and extra-synaptic receptors, unprocessed trauma, trauma manifestations, and so much more.  Follow her on IG @onethumbel  

Glutamate, GABA, Dopamine, Norepinephrine, Serotonin, and the whole HPA axis (stress response). These are some of the important systems in your brain that get messed up when you blast your brain with alcohol all the time. Then when we quit drinking, these get even more messed up. In this episode you'll learn what these 6 do, how alcohol messes them up, how they get more messed up when we quit drinking, and how long it takes for them to recover in sobriety. (TW: link between addiction and suicide when I discuss serotonin) What to listen to next E38: Central Nervous System Depression E75: How Sleep Improves from Actively Drinking to Long Term Sobriety E170: Here's Why The First Year of Sobriety is So Hard E201: Your Dysregulated Stress Response Sober Powered Skills Episode: Feel Calm, Boost Dopamine, Improve Your Mood, and Reduce Stress https://www.soberpowered.com/skills Sober Support: Community & Meetings: Living a Sober Powered Life https://www.soberpowered.com/membership Anger Management Program https://www.soberpowered.com/anger Sober Powered Skills (bonus episodes with practical application and coping skills) https://www.soberpowered.com/skills Weekly emails on Thursdays https://www.soberpowered.com/email Free resources https://www.soberpowered.com/free   Thank you for supporting this show by supporting my sponsors. Learn more: https://www.soberpowered.com/sponsors If you enjoyed this episode please consider buying me a coffee to support my work https://www.buymeacoffee.com/soberpowered Sources are posted on my website Disclaimer: all of the information described in this podcast is my interpretation of the research combined with my opinion. This is not medical advice. Learn more about your ad choices. Visit megaphone.fm/adchoices

You've probably heard of Serotonin, or Dopamine. Those are the sexy neurotransmitters that get all the press. However, you have probably not heard of Glutamate. Which is a shame because it is probably the most important neurotransmitter in the brain, responsible in large part for its growth, and also its plasticity. Mark Mattson is a neuroscientist with a distinguished career as Director of the Laboratory of Neurosciences at the National Institute on Aging. While initially interested in developmental biology in animals, Mattson's work in endocrinology led him to become to study the effect of hormones on the brain. Eventually he began to focus on the role of the Glutamate in neuroplasticity and Alzheimers disease. He realized how essential that neurotransmitter was for understanding the very formation of the brain, the growth of neurons, and the formation of axons and dendrites, as well as its key role in brain functions including learning and memory .I first got to know Mark when we co-organized a workshop on Pattern Processing in the Human Brain, where we invited well known neuroscientists as well as computer scientists and AI researchers to come together to discuss areas of joint interest. The idea was to explore key features that may underlie consciousness, and also to explore how to ensure how to avoid the error-prone brain functioning such as one finds in Schizophrenia as AI systems are developed. The public event associated with the workshop was entitled Creativity and Madness, and involved a dialogue between me and actor Johnny Depp. Most recently, Mark has written a fascinating book, entitled Sculptor and Destroyer, to describe and explain the importance of Glutamate in brain formation and functioning. We had a fascinating discussion about that, and also how he became interested in the brain after initially planning to become a veterinarian. I hope you find the discussion as enlightening as I did. As always, an ad-free video version of this podcast is also available to paid Critical Mass subscribers. Your subscriptions support the non-profit Origins Project Foundation, which produces the podcast. The audio version is available free on the Critical Mass site and on all podcast sites, and the video version will also be available on the Origins Project Youtube. Get full access to Critical Mass at lawrencekrauss.substack.com/subscribe

In this episode, we discuss the Excitation and Inhibition Phenomena in Autism. There are many biological aspects implicating the E/I balance, and the Nervous System needs a healthy balance. This episode extends slightly downstream of the Genetic and Protein implications previously discussed. We discuss cortical and subcortical areas, sensations, introduce Glutamate and GABA, and discuss the critical period. The critical period is, pardon the pun, a critical period for Autism. In addition, we discuss BDNF and introduce neuroplasticity. Finally, we discuss Melanin and Melanopsin and sunlight and modern light, and the vast implications from our new environment. To end, we connect many modern diseases to these biological factors.See Dr. Jack Kruse Quantum Engineering 45Email: info.fromthespectrum@gmail.com

Today we have Dr. Johnathan Edwards, an anesthesiologist and medical practitioner who specializes in human health and optimization. He is perhaps best known for treating mental health conditions with ketamine,  a dissociative anesthetic that is used for general anesthesia, pain relief, depression and epilepsy. John also uses ketamine to help adolescents overcome depression and suicidal ideation. In today's interview, we talk about his new book, “The Revolutionary Ketamine: The Safe Drug That Effectively Treats Depression and Prevents Suicide.” More Americans have died from suicide than all the wars since Vietnam. The suicide rate among 10- to-24-year-olds in this country increased 62 percent from 2007 through 2021. As John points out in today's discussion, most people are not aware that American children between the ages of 10 and 14 are twice as likely to die from suicide than homicide. Show notes: [00:02:39] Dawn explains that suicide is a pressing problem in America, with more Americans dying of suicide than from all the wars since Vietnam. She also points out that police and firefighters are more likely to die from suicide than in the line of duty. John then gives an overview of ketamine and its ability to help treat depression and suicidal thoughts. [00:06:56] Dawn pivots to mention the dark side of ketamine, including ketamine misuse and overdose.  Recent studies have reported a worldwide increase in ketamine misuse and overdoses. Back in October, Mathew Perry, one of the stars of the popular sit-com “Friends,” died from what the Los Angeles cororner described as the acute effects of ketamine. Because this was such a high-profile case, Dawn asks John to discuss the potential adverse effects of ketamine. [00:13:03] Ken mentions a 2022 study in the American Journal of Drug and Alcohol Abuse that looked at ketamine overdoses and deaths. The study found no cases of overdose or death from ketamine used in a clinical setting as therapy for depression. Ken asks if there is anything John would like to add about ketamine and safety. [00:13:059] Dawn shifts to talk about John's background, mentioning that he grew up riding dirt bikes and eventually raced bikes professionally. [00:15:18] Ken asks John to share his story of how a junior college professor sparked his interest in science. [00:17:49] Dawn mentions that John jumped around from Eastern Virginia Medical School, to the University of Reno, to the University of Utah, at which point it looked as though he was heading for a career in internal medicine. Dawn asks why John changed his mind and decided not to pursue that career path. [00:19:40] Dawn asks John what led him to the University of South Florida. [00:20:18] Ken asks John about another career shift that came about as the result of a suggestion from one of John's professors. [00:21:42] Dawn asks about John's motivation to move to Las Vegas to be close to his father. [00:22:59] Dawn asks John to explain what motivated him and his wife to move to France after their daughter turned five. [00:24:55] Dawn asks John to talk about the transition of ketamine from anesthetic to antidepressant. [00:28:16] In his book on ketamine, John writes about how the benefits of supervised psychedelic therapy can be broken down into four effects. Ken asks John to briefly explain each of these effects. [00:31:39] Dawn asks John to explain how ketamine manipulates the function of brain receptors as an antagonist and agonist. [00:33:40] Dawn mentions that some people do not believe that ketamine functions as a classic psychedelic like psylocibin or LSD. She asks John if he agrees. [00:35:54] Ken mentions a recent STEM-Talk interview with Mark Mattson discussing glutamate. In Mark's book, “Sculptor and Destroyer: Tales of Glutamate,” he points out that ketamine's highest interactions are with glutamate, and this affinity has been shown to alleviate depression and schizophrenia.

What is depression? Neil deGrasse Tyson and co-hosts Chuck Nice and Gary O'Reilly break down the neuroscience behind major depression, its treatments, and the factors that contribute to this pervasive condition with neuroscientist Heather Berlin, PhD.NOTE: StarTalk+ Patrons can listen to this entire episode commercial-free here: https://startalkmedia.com/show/why-we-get-depressed-with-heather-berlin/Thanks to our Patrons Geoff Malone, Neander Rowlett, Brial Teel, Baran Blaser, Maxwell Miller, Doug Litwin, and Edward Bally for supporting us this week.

In part 2 of my Neuroscience episodes about antidepressants I'm diving into the Glutamate Hypothesis. I chat about the role of the glutamatergic system within the brain in helping us to better understand why some people don't respond well to the first line of treatments, such as SSRIs. I'm also diving into treatment resistant depression, electro convulsive therapy (ECT) neuroplasticity and transcranial magnetic stimulation. LINKS: Listen to Part 1 of this series The Neuroscience of Anti-Depressants: The Monoamine Hypothesis at https://pod.fo/e/21783a . Read the paper ‘Glutamatergic System in Depression and Its Role in Neuromodulatory Techniques Optimization' accessible via PUBMED https://tr.ee/glutamatergic-paper . Listen to episode 50. Stress on the brain and how to reverse its effects at https://pod.fo/e/1f8306 . Listen to episode 257 my episode on Ketamine as a treatment for depression here https://bit.ly/Dyfm-ketamine. Join the DYFM Facebook Group https://bit.ly/dyfm-group . Follow @dyfmpodcast on IG  Follow @alexispredez on IG   Follow @listnrentertainment on IG  CREDITS Host: Alexis Fernandez       Executive Producer & Editor: Elise CooperDigital Producer: Zoe Panaretos DYFM Social Producer: Shania MaguaManaging Producer: Sam Cavanagh  Find more great podcasts like this at www.listnr.com/  See omnystudio.com/listener for privacy information.

Today we have Dr. Mark Mattson, an adjunct professor of neuroscience at Johns Hopkins School of Medicine who is making his third appearance on STEM-Talk. Today's interview focuses on Mark's research into glutamate and comes on the heels of the publication of Mark's new book, “Sculptor and Destroyer: Tales of Glutamate – The Brain's Most Important Neurotransmitter.” Today Mark explains how more than 90 percent of the neurons in the brain deploy the little-known molecule glutamate as their neurotransmitter. Glutamate controls the structure and function of the brain's neuronal networks and mediates many of our human capabilities, such as learning, memory, creativity, and imagination. But there's also a dark side to glutamate. Mark shares how it can play a causal role in the development of disorders such as autism, schizophrenia, and epilepsy as well as diseases such as Alzheimer's, Parkinson's, and ALS. Mark is affectionally known as the godfather of intermittent fasting and his first appearance on STEM-Talk focused on the many ways that fasting optimizes healthspan and even lifespan. His second STEM-Talk interview followed the publication of his book, “The Intermittent Fasting Revolution: The Science of Optimizing Health and Enhancing Performance.” Show Notes: [00:04:05] Dawn welcomes Mark back to STEM-Talk for his third appearance. Dawn mentions that our previous two episodes with mark focused on intermittent fasting, and that Mark is considered the godfather of intermittent fasting. Dawn goes on to mention that the National Institutes of Health has described Mark as “one of the world's top experts on the potential cognitive and physical health benefits of intermittent fasting.” [00:05:05] Ken mentions that in our previous STEM-TALK interview Mark shared that he was working on a new book about glutamate. Ken adds that Mark considers his research on glutamate to be his most important work. Ken asks why Mark feels as though this research is his most important, given his substantial contributions in other areas. [00:05:49] Dawn mentions that Mark's research hasn't been limited to just glutamate and intermittent fasting. Mark has contributed to a broad range of topics including brain evolution, cognition, the impact of diet and lifestyle on brain health, as well as the pathogenesis and treatment of various neurological conditions. Dawn asks Mark to talk about his motivation to understand how the pieces of the “brain puzzle” fit together, which is the core motivation for his pursuing a broad scope of research. [00:07:22] Ken asks about Mark's postdoc work, where he discovered that glutamate sculpts the formation of hippocampal neuronal networks during development. [00:09:33] Ken mentions that while Mark was at the University of Kentucky, he discovered that the amyloid beta peptide which accumulates in the brain during Alzheimer's disease renders neurons vulnerable to excitotoxicity. Ken goes on to say that since this, and the previously mentioned discovery, neurologists have shown that neuronal network hyperexcitability occurs early in Alzheimer's and may contribute to neuronal degeneration. Ken asks Mark to talk about the significance of these two discoveries. [00:13:39] Dawn asks Mark to talk about the significance of glutamate as a molecule and how it controls the formation of nerve cell networks as the brain develops in utero. [00:17:50] Ken asks Mark why he thinks that glutamate rarely comes up in discussions of neurotransmitters, despite its importance of its functions. [00:19:58] Ken asks Mark to expound on the “dark side” of glutamate. [00:26:04] Dawn mentions that we may never know where in the universe glutamate originated, and while it might have been here on Earth, it perhaps originated somewhere else in the universe. Dawn asks Mark to expand on that notion. [00:28:33] Ken shifts to the history of glutamate research, explaining that up until the 1940's,

In today's episode I will be sharing the exact process by which alcohol changes your brain! If you're thinking about getting sober then this podcast is a must listen!❌ MEN ONLY: Exclusive Free Video Training On “The Secret To Controlling Alcohol”: http://www.soberclear.com/2024-men

This episode is brought to you by WHOOP, Bioptimizers, and Lifeforce. Glutamate is a neurotransmitter essential for our health and plays a crucial role in activating our nervous system and immune response.However, when foods are ultra-processed, they can create glutamate in excess amounts, which, when overly consumed, can cause symptoms associated with anxiety, ADHD, Autism, and increase chronic inflammation in our body. Today on The Dhru Purohit Podcast, Dhru sits down with Dr. Katherine Reid to discuss glutamate, its link to monosodium glutamate, and the alarming amount created in our food supply through processed proteins. Dr. Katherine Reid earned her PhD in biochemistry, specifically focusing on protein chemistry. She switched focus soon after her daughter was diagnosed with autism and discovered that reducing MSG in the diet managed many of her daughter's symptoms.Dr. Reid is the founder of Unblind My Mind, Inc., a non-profit organization dedicated to improving health through informed food choices, and now works closely with the public, including the medical community, to devise food solutions for people suffering from a wide variety of chronic inflammatory conditions. She is also the author of the newly released book Fat, Stressed, and Sick: MSG, Processed Food, and America's Health Crisis.In this episode, Dhru and Dr. Reid dive into (audio version / Apple Subscriber version):-What is glutamate and its connection to monosodium glutamate (MSG) (2:51 / 2:51)-The top food sources of glutamate and MSG (11:00 / 8:00)-Independent testing for glutamate in a product (28:15 / 25:10)-Dr. Reid's personal experience with changing her daughter's diet after a diagnosis of Autism spectrum disorder (35:14 / 30:38) -The FDA's position on glutamate (58:40 / 54:12)-Why are some individuals more impacted by glutamate exposure and lifestyle factors that can reduce glutamate release within our body (1:02:42 / 58:06)-The REID Diet protocol and who can benefit from it (1:11:25 / 1:06:49) -The correlation between glutamate levels in gluten and dairy in Europe versus America (1:31:44 / 1:27:10)-Research on glutamate and the work that still needs to be done (1:41:26 / 1:36:54)Also mentioned in this episode:-Dr. Reid's new book Fat, Stressed, and Sick: MSG, Processed Foods, and America's Health Crisis-Unblind My Mind - Dr. Reid's Nonprofit-The REID Diet WHOOP is a personalized digital fitness tracker. To get yours, go to join.whoop.com/dhru and get your first month free.Get 10% off and a special bonus gift with your Bioptimizers purchase. Go to magbreakthrough.com/dhru and use the code DHRU10 at checkout.Right now, get 15% off your first purchase of Lifeforce at Mylifeforce.com with code DHRU. Hosted on Acast. See acast.com/privacy for more information.

I'm delighted to be back with for episode 93 of Season Six of The One Thing podcast. This episode comes at an opportune time as many individuals are grappling with shifts in their mental well-being due to seasonal changes, alterations in weather, and fluctuations in the natural environment. There my be worsening ADHD, Anxiety, Depression, Autism, or PANS/PANDAS fluctuations especially with viral/flu season upon us. These changes can often spark curiosity about the reasons behind these fluctuations. What does the immune system have to do on with mental health and behavior?When considering the crucial link between the immune system and mental health, I couldn't think of a more suitable guest than Dr. Emily Gutierrez, whom I had the pleasure of meeting through IntelxxDNA. Her expertise lies in comprehending the intersection of nutrition, the immune system, and mental health. Specifically, she focuses on how genetics and nutrition influence cognitive functions in individuals with conditions like ADHD, anxiety, depression, autism, and pans/ pandas, and more. Her profound knowledge in these areas is evident throughout this episode as she provides a well-structured framework for understanding the interplay between mental health and the immune system, exploring various factors driving immune responses.Notably, neurotransmitters like glutamate play a pivotal role in the realm of mental health, a topic we delve deeply into during our discussion. We touch upon which genetic elements contribute to immune system activation, as well as the environmental triggers that impact both the immune system and mental well-being.About: DR. EMILY GUTIERREZ, DNP, CPNP, APRN, PMHS, IFM-CPDr. Gutierrez is a doctor of nursing practice and pediatric nurse practitioner that has been providing pediatric functional medicine care to patients for over a decade. She received her doctorate from Johns Hopkins University in Baltimore, MD, and her masters degree as a pediatric nurse practitioner at the University of Texas in Austin, TX. Dr. Gutierrez is board certified in functional medicine by the Institute of Functional Medicine in addition to dual board certifications by the Pediatric Nursing Certification Board as both a pediatric nurse practitioner and a primary care mental health specialist. Dr. Gutierrez is adjunct faculty at Johns Hopkins University and a fellow of the Medical Academy of Pediatric Special Needs. She has a busy pediatric functional medicine practice in Austin, Texas, and also is a founder of Neuro Nutrients, a nutraceutical company that provides custom formulations for supporting mental health needs naturally.Socials: Website: Instagram See below for resources mentioned in the episode: ⁠Glutamate Support- Calming Support⁠⁠ Glutamate Support- NAC 800mg⁠ ⁠Serotonin Support- Mood Support⁠⁠ Haroon, E., Miller, A. & Sanacora, G. Inflammation, Glutamate, and Glia: A Trio of Trouble in Mood Disorders. Neuropsychopharmacol 42, 193–215 (2017). https://doi.org/10.1038/npp.2016.19⁠9 --- Support this podcast: https://podcasters.spotify.com/pod/show/onethingpod/support

Tinnitus is ringing in the ears, and it can drive a person crazy. Today I want to cover some tips to get rid of tinnitus naturally. Tinnitus is a little bit mysterious and hasn't been fully figured out. Typical treatments for tinnitus are medications called Gabapentin and Klonopin. These two medications both have a mechanism to increase GABA in the brain. GABA is an inhibitory neurotransmitter and slows down the central nervous system. An interesting study shows that people with tinnitus may have lowered GABA and upregulated glutamate. Glutamate stimulates the brain. The problem with GABA supplements is that they don't cross the blood-brain barrier. This means they will have a difficult time penetrating into the brain to create any effect. However, an amino acid called taurine turns into GABA and can pass the blood-brain barrier. Just be sure to take taurine on an empty stomach. In addition to increasing GABA, it's essential to inhibit glutamate. MSG and aspartame are high in glutamate, so it's important to avoid foods containing these ingredients. Other sources of glutamate to avoid: • Hydrolyzed protein • Calcium caseinate • Yeast extract • Textured protein • Whey protein • Soy protein isolates • Soy sauce DATA: https://www.sciencedirect.com/science... https://www.ncbi.nlm.nih.gov/pmc/arti... https://www.tinnitusformula.com/libra... https://www.truthinlabeling.org/names... https://www.lifeextension.com/magazin...

The main topic of this podcast is migraines and Nurse Doza shares information about their characteristics. He emphasizes that migraines indicate inflammation in the body and should not be normalized as a daily occurrence. Nurse Doza also discusses methods to find relief and prevent migraines in the future, highlighting the significance of addressing the underlying inflammation.    TIMESTAMPS: 00:00 START 04:36 Living with chronic migraines. 09:36 Glutamate and migraines. 12:29 Vitamin B6 and neurotransmitters. 15:30 Liver detox and brain health. 19:19 Low melatonin and migraines. 23:47 Natural pain relievers. 26:09 Migraine treatment with supplements. 30:39 Migraine and stroke risk. 33:18 Underlying issues causing migraines. 36:24 Chronic migraines and natural remedies.   THE D Before diving into the show notes on migraines, it's important to touch upon a supplement that could play a crucial role in migraine relief - The D. Have you had your D yet? It's not just any Vitamin D3 supplement; it's been enhanced with K2 for optimal absorption and efficacy. If you're searching for a potent and high-quality Vitamin D supplement, The D by MSW is your go-to. Click on the link below to explore more and make a purchase. https://www.mswnutrition.com/products/the-d/?ref=nursedoza   1. Understanding the Role of Inflammation in Migraines: Migraines can be an indication of inflammation within the body – signaling that something is not right^(1^). Chronic migraine: Defined as a headache occurring on 15+ days in a month for over three months, having migraine features on at least 8 of those days^(1^). Migraine & Disability: Ranked second globally as a cause of disability^(1^). Glutamate and CNS: Elevated glutamate levels in blood and cerebrospinal fluid of migraine patients hint at its role in migraine pathophysiology^(2^). Vitamin B6: Its roles extend beyond being a coenzyme in converting excitatory glutamate into inhibitory GABA; it's also crucial for neurotransmitter production and other neural pathways^(3^). NAC and Glutamate: NAC can regulate the glutamatergic system, which is associated with numerous psychiatric disorders^(4^). Reference 1 | Reference 2 | Reference 3 | Reference 4 2. Identifying Potential Migraine Triggers: Finding the underlying cause or trigger of your migraine is paramount^(1^). Some probable triggers include: Stress (80%) Hormonal Changes (65%) Skipped Meals (57%) ... and many more listed above. Additionally, imbalances in melatonin and serotonin levels have been linked to migraines^(2^,3^). Reference 1 | Reference 2 | Reference 3 3. Natural Pain Relievers for Migraine Management: Several natural treatments, like turmeric, fish oil, vitamin B2, magnesium, and butterbur, may aid in providing relief^(1^). Vitamin D: Supplementation can reduce the frequency of attacks in migraine sufferers^(4^,5^). Serotonin (5-HT): Implicated in migraine due to its vasoconstrictor effects and presence in pain-related regions^(3^). Melatonin: Demonstrates potential analgesic effects in various conditions, including migraines^(3^). Reference 1 | Reference 3 | Reference 4 | Reference 5 4. Chiropractic Treatments for Migraines: Studies suggest that chiropractic spinal manipulative therapy (CSMT) may be an effective treatment for migraines^(1^). Reference 1 5. Migraines & Stroke Risks: People with migraine auras have a slightly heightened risk of stroke^(1^). Consistent associations have been made between migraines with aura and increased risk of ischemic stroke^(2^). Reference 1 | Reference 2 As we conclude today's discussion, let's not forget the potential role of Vitamin D3 in migraine management. Once again, for those who are keen on exploring a top-notch Vitamin D3 supplement enriched with K2, consider giving The D by MSW a shot. It's formulated for those who settle for nothing but the best.   Click the link below to secure your bottle today. Make the right choice for your health! https://www.mswnutrition.com/products/the-d/?ref=nursedoza Disclaimer: Always consult with a healthcare professional before starting any supplement or making significant changes to your health routine.

Today, we are talking about how neurons communicate with each other via neurotransmitters and how these neurotransmitters contribute to various brainwave states. Then, we dive into different auditory stimuli that can entrain the brain to certain brainwave states, thus permitting the supposed ongoing release of certain neurotransmitters. This may ultimately affect mood, productivity, relaxation, and more! Stay tuned... this is a good one! Topics: 1. Introduction: - The potential of sound to optimize brain chemistry - Different types of auditory stimuli: music, sound frequencies, natural soundscapes, and binaural beats 2. Understanding the Brain: - Anatomy of the Central Nervous System: Neurons and Glia cells - Structure of Neurons: Cell body, axon, and dendrite - Neurotransmitters and synapses 3. Neural Communication Process: - Resting Membrane Potential and its maintenance - Stimulation of Neurons - Action Potential: - Depolarization and Repolarization - Role of Sodium and Potassium ions - Propagation of Action Potential and its role in neurotransmitter release 4. Brainwaves & Neurotransmitters: - Introduction to Brainwaves - Role of Amino Acid Neurotransmitters: GABA (inhibitory) and Glutamate (excitatory) - Different Brainwave Types: Delta, Theta, Alpha, Beta, and Gamma waves 5. External Influences on Brainwaves: - Auditory stimuli - The concept of brainwave entrainment 6. Application & Implications: - Using brainwave entrainment to optimize various tasks: 1. Morning Meditation or Relaxation 2. Work, Problem Solving, and Analytical Thinking 3. Creative Work or Brainstorming 4. Deep Work or High-Level Information Processing 5. Breaks, Quick Naps, or Short Meditations 6. Evening Relaxation or Preparing for Sleep 7. Deep Meditation or Deep Sleep 7. Scientific Findings on Music & Brainwaves: - Mozart's Sonata in D Major for Two Pianos K448 - Beethoven's "Für Elise" - The monochord sounds and its effects - "Pleasant" music's influence on patients with depression, schizophrenia, or anxiety 8. Binaural Beats: - Introduction and concept - How you can use binaural beats 9. Conclusion: - Importance of balanced brainwave activity - The interrelationship between neurotransmitters and brainwaves Thanks so much for tuning in! Pre-Order Chloe's Book "⁠75 Gut-Healing Strategies & Biohacks⁠" and email thesynthesisofwellness@gmail.com a screenshot of the order confirmation to enter the GIVEAWAY! If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more! Or visit ⁠⁠⁠⁠⁠⁠⁠⁠linktr.ee/synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠ to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

    Today, we're diving deep into a topic that has long been cloaked in misconceptions and half-truths. It's time to unmask the hidden dangers of alcohol, a substance that has woven its way into the fabric of our society, often without us even realizing the extent of its impact. The Deceptive Nature of Alcohol Alcohol, a legal and socially accepted drug, has long been touted as a means of relaxation, celebration, and even escape. But what if I told you that we've been living a lie, one carefully crafted by the alcohol industry? It's time to peel back the layers and reveal the truth. The Dopamine Deception Let's start with a fundamental aspect of alcohol's deception: its effect on our brain's reward system. You see, when you take that sip of wine or down a beer, your brain is flooded with dopamine, the feel-good neurotransmitter. This rush of pleasure creates an illusion of relaxation and happiness, but it's merely a fleeting high, followed by a crash. Think of it as a twisted game of emotional roulette. Glutamate's Grip The deceit doesn't stop there. Alcohol also messes with another important player in our brain chemistry – glutamate. This neurotransmitter is responsible for excitatory signals in the brain, and alcohol acts as a sedative, suppressing glutamate. So, while you may feel relaxed, your brain is actually being dulled, affecting your cognitive abilities and emotional responses. Alcohol vs. Other Drugs Some may argue that alcohol is no different from other drugs, and they would be right. In many ways, alcohol shares similarities with substances we often stigmatize. The difference? Alcohol's PR campaign. The alcohol industry has expertly marketed its product as a harmless indulgence, while other drugs are condemned. It's a double standard that has shaped our perception. The Youth Deception Young people, the future of our world, are particularly vulnerable to alcohol's deception. They aren't being adequately informed about the dangers of alcohol and nicotine, which both have the potential to hijack their natural dopamine production. It's a sinister cycle of addiction that's perpetuated by design. Breaking the Chains It's time to break the chains of deception, to recognize alcohol for what it truly is – a drug with the potential to dull our lives, impair our judgment, and cause addiction. It's time for open conversations, informed choices, and a reevaluation of our societal norms. I want to leave you with this: knowledge is power. By understanding the deceptive nature of alcohol and the impact it has on our lives, we can make more informed choices and help guide our youth towards healthier decisions. It's time to lift the veil and see alcohol for what it truly is.  Get full show notes, resources, and links on my website! Are you ready to go deeper? I am giving you the keys to the castle. If you enjoyed this podcast and want to hear more, make sure to subscribe so you'll never miss an episode! You can connect with me on Facebook, Instagram, TikTok or Youtube

#189: We uncover the connection between gluten, glutamate, and inflammation in PCOS. You'll learn how these ingredients affect our bodies and mood, and their role in PCOS inflammation and symptoms. We also explain how gluten, found in wheat, rye, and barley, affects the brain-gut connection, causing brain fog and anxiety. So tune in! You're about to learn how gluten, gliadin, and glutamate can turn up the inflammation dial in our system. Think insulin resistance, abdominal fat, and immune system imbalances. Join us on this journey to understand the impact of gluten and glutamate on PCOS! Download The Cysterhood App, the largest community of PCOS women learning to lose weight & reverse symptoms with daily meals & workouts designed for PCOS! What's Your PCOS Type? - Take the quiz! Metabolism Plus - Our PCOS Supplement Line! Ovasitol: 15% OFF CONNECT WITH US: Website Instagram Tik Tok YouTube Pinterest While Tallene is a Registered Dietitian and Sirak a Personal Trainer, this podcast provides general information about PCOS. It is not meant to serve as fitness, nutrition or medical advice related to your individual needs. If you have questions, please talk to a medical professional. For our full privacy policy, please click on the following link: (bit.ly/PCOSPrivacyPolicy) Links included in this description may be affiliate links. If you purchase a product or service with the links that we provide, we may receive a small commission. There is no additional charge to you! Thank you for supporting our channel so we can continue to provide you with free content each week!

Dr. Aimie Apigian, MD, MS, MPH is the leading medical expert on how life experiences get stored in the body and restoring the body to its best state of health through her signature model and methodology, The Biology of Trauma™. She is a double board-certified medical physician in Preventive Medicine and Addiction Medicine. She is also a Certified Functional Medicine physician and has training and certifications specifically in neuro-autoimmunity, nutrition, and genetics for addictions, mental health, and mood and behavioral disorders. Dr. Aimie offers science-based solutions on how to rewire the nervous system with The Biology of Trauma. Accelerating the healing journey through recovery to resilience, presence, and aliveness. Dr. Aimie is the founder and CEO of Trauma Healing Accelerated, offering her foundational online course: “The 21 Day Journey to Calm Aliveness”, which is an experiential journey into the nervous system that is open to all as well as her 8 module certification course for practitioners, “Biology of Trauma” that teaches the protocols of addressing The Biology of Trauma on the different systems of the body. Key Topics: - Redefining trauma - trauma is not just one big event - What a trauma response looks like - Safety physiology vs. threat physiology - How trauma doesn't allow the body to bounce back - The disconnect between mind and body and where it comes from - How we can get out of a trauma response mode - An explanation of somatic experiencing and how it brings safety to the body Learn more about Dr. Aimie's programs at traumahealingaccelerated.com

Dr. Aimie Apigian, MD, MS, MPH is the leading medical expert on how life experiences get stored in the body and restoring the body to its best state of health through her signature model and methodology, The Biology of Trauma™. She is a double board-certified medical physician in Preventive Medicine and Addiction Medicine. She is also a Certified Functional Medicine physician and has training and certifications specifically in neuro-autoimmunity, nutrition, and genetics for addictions, mental health, and mood and behavioral disorders. Dr. Aimie offers science-based solutions on how to rewire the nervous system with The Biology of Trauma. Accelerating the healing journey through recovery to resilience, presence, and aliveness. Dr. Aimie is the founder and CEO of Trauma Healing Accelerated, offering her foundational online course: “The 21 Day Journey to Calm Aliveness”, which is an experiential journey into the nervous system that is open to all as well as her 8 module certification course for practitioners, “Biology of Trauma” that teaches the protocols of addressing The Biology of Trauma on the different systems of the body. Key Topics: - Redefining trauma - trauma is not just one big event - What a trauma response looks like - Safety physiology vs. threat physiology - How trauma doesn't allow the body to bounce back - The disconnect between mind and body and where it comes from - How we can get out of a trauma response mode - An explanation of somatic experiencing and how it brings safety to the body Learn more about Dr. Aimie's programs at traumahealingaccelerated.com

ReferencesWe considered the complexity of the machinery to excrete ammonium in the context of research on dietary protein and how high protein intake may increase glomerular pressure and contribute to progressive renal disease (many refer to this as the “Brenner hypothesis”). Dietary protein intake and the progressive nature of kidney disease: the role of hemodynamically mediated glomerular injury in the pathogenesis of progressive glomerular sclerosis in aging, renal ablation, and intrinsic renal diseaseA trial that studied low protein and progression of CKD The Effects of Dietary Protein Restriction and Blood-Pressure Control on the Progression of Chronic Renal Disease(and famously provided data for the MDRD eGFR equation A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study GroupWe wondered about dietary recommendations in CKD. of note, this is best done in the DKD guidelines from KDIGO Executive summary of the 2020 KDIGO Diabetes Management in CKD Guideline: evidence-based advances in monitoring and treatment.Joel mentioned this study on red meat and risk of ESKD. Red Meat Intake and Risk of ESRDWe referenced the notion of a plant-based diet. This is an excellent review by Deborah Clegg and Kathleen Hill Gallant. Plant-Based Diets in CKD : Clinical Journal of the American Society of NephrologyHere's the review that Josh mentioned on how the kidney appears to sense pH Molecular mechanisms of acid-base sensing by the kidneyRemarkably, Dr. Dale Dubin put a prize in his ECG book Free Car Prize Hidden in Textbook Read the fine print: Student wins T-birdA review of the role of the kidney in DKA: Diabetic ketoacidosis: Role of the kidney in the acid-base homeostasis re-evaluatedJosh mentioned the effects of infusing large amounts of bicarbonate The effect of prolonged administration of large doses of sodium bicarbonate in man and this study on the respiratory response to a bicarbonate infusion: The Acute Effects In Man Of A Rapid Intravenous Infusion Of Hypertonic Sodium Bicarbonate Solution. Ii. Changes In Respiration And Output Of Carbon DioxideThis is the study of acute respiratory alkalosis in dogs: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC293311/?page=1And this is the study of medical students who went to the High Alpine Research Station on the Jungfraujoch in the Swiss Alps https://www.nejm.org/doi/full/10.1056/nejm199105163242003Self explanatory! A group favorite! It Is Chloride Depletion Alkalosis, Not Contraction AlkalosisEffects of chloride and extracellular fluid volume on bicarbonate reabsorption along the nephron in metabolic alkalosis in the rat. Reassessment of the classical hypothesis of the pathogenesis of metabolic alkalosisA review of pendrin's role in volume homeostasis: The role of pendrin in blood pressure regulation | American Journal of Physiology-Renal PhysiologyInfusion of bicarbonate may lead to a decrease in respiratory stimulation but the shift of bicarbonate to the CSF may lag. Check out this review Neural Control of Breathing and CO2 Homeostasis and this classic paper Spinal-Fluid pH and Neurologic Symptoms in Systemic Acidosis.OutlineOutline: Chapter 11- Regulation of Acid-Base Balance- Introduction - Bicarb plus a proton in equilibrium with CO2 and water - Can be rearranged to HH - Importance of regulating pCO2 and HCO3 outside of this equation - Metabolism of carbs and fats results in the production of 15,000 mmol of CO2 per day - Metabolism of protein and other “substances” generates non-carbonic acids and bases - Mostly from sulfur containing methionine and cysteine - And cationic arginine and lysine - Hydrolysis of dietary phosphate that exists and H2PO4– - Source of base/alkali - Metabolism of an ionic amino acids - Glutamate and asparatate - Organic anions going through gluconeogenesis - Glutamate, Citrate and lactate - Net effect on a normal western diet 50-100 mEq of H+ per day - Homeostatic response to these acid-base loads has three stages: - Chemical buffering - Changes in ventilation - Changes in H+ excretion - Example of H2SO4 from oxidation of sulfur containing AA - Drop in bicarb will stimulate renal acid secretion - Nice table of normal cid-base values, arterial and venous- Great 6 bullet points of acid-base on page 328 - Kidneys must excrete 50-100 of non-carbonic acid daily - This occurs by H secretion, but mechanisms change by area of nephron - Not excreted as free H+ due to minimal urine pH being equivalent to 0.05 mmol/L - No H+ can be excreted until virtually all of th filtered bicarb is reabsorbed - Secreted H+ must bind buffers (phosphate, NH3, cr) - PH is main stimulus for H secretion, though K, aldo and volume can affect this.- Renal Hydrogen excretion - Critical to understand that loss of bicarb is like addition of hydrogen to the body - So all bicarb must be reabsorbed before dietary H load can be secreted - GFR of 125 and bicarb of 24 results in 4300 mEq of bicarb to be reabsorbed daily - Reabsorption of bicarb and secretion of H involve H secretion from tubular cells into the lumen. - Thee initial points need to be emphasized - Secreted H+ ion are generated from dissociation of H2O - Also creates OH ion - Which combine with CO2 to form HCO3 with the help of zinc containing intracellular carbonic anhydrase. - This is how the secretion of H+ which creates an OH ultimately produces HCO3 - Different mechanisms for proximal and distal acidification - NET ACID EXCRETION - Free H+ is negligible - So net H+ is TA + NH4 – HCO3 loss - Unusually equal to net H+ load, 50-100 mEq/day - Can bump up to 300 mEq/day if acid production is increased - Net acid excretion can go negative following a bicarb or citrate load - Proximal Acidification - Na-H antiporter (or exchanger) in luminal membrane - Basolateral membrane has a 3 HCO3 Na cotransporter - This is electrogenic with 3 anions going out and only one cation - The Na-H antiporter also works in the thick ascending limb of LOH - How about this, there is also a H-ATPase just like found in the intercalated cells in the proximal tubule and is responsible for about a third of H secretion - And similarly there is also. HCO3 Cl exchanger (pendrin-like) in the proximal tubule - Footnote says the Na- 3HCO3 cotransporter (which moves sodium against chemical gradient NS uses negative charge inside cell to power it) is important for sensing acid-base changes in the cell. - Distal acidification - Occurs in intercalated cells of of cortical and medullary collecting tubule - Three main characteristics - H secretion via active secretory pumps in the luminal membrane - Both H-ATPase and H-K ATPase - H- K ATPase is an exchange pump, k reabsorption - H-K exchange may be more important in hypokalemia rather than in acid-base balance - Whole paragraph on how a Na-H exchanger couldn't work because the gradient that H has to be pumped up is too big. - H-ATPase work like vasopressin with premise H-ATPase sitting on endocarditis vesicles a=which are then inserted into the membrane. Alkalosis causes them to be recycled out of the membrane. - H secretory cells do not transport Na since they have few luminal Na channels, but are assisted by the lumen negative tubule from eNaC. - Minimizes back diffusion of H+ and promotes bicarb resorption - Bicarbonate leaves the cell through HCO3-Cl exchanger which uses the low intracellular Cl concentration to power this process. - Same molecule is found on RBC where it is called band 3 protein - Figure 11-5 is interesting - Bicarbonate resorption - 90% in the first 1-22 mm of the proximal tubule (how long is the proximal tubule?) - Lots of Na-H exchangers and I handed permeability to HCO3 (permeability where?) - Last 10% happens distally mostly TAL LOH via Na-H exchange - And the last little bit int he outer medullary collecting duct. - Carbonic anhydrase and disequilibrium pH - CA plays central role in HCO3 reabsorption - After H is secreted in the proximal tubule it combines with HCO# to form carbonic acid. CA then dehydrates it to CO2 and H2O. (Step 2) - Constantly moving carbonic acid to CO2 and H2O keeps hydrogen combining with HCO3 since the product is rapidly consumed. - This can be demonstrated by the minimal fall in luminal pH - That is important so there is not a luminal gradient for H to overcome in the Na-H exchanger (this is why we need a H-ATPase later) - CA inhibitors that are limited tot he extracellular compartment can impair HCO3 reabsorption by 80%. - CA is found in S1, S2 but not S3 segment. See consequence in figure 11-6. - The disequilibrium comes from areas where there is no CA, the HH formula falls down because one of the assumptions of that formula is that H2CO3 (carbonic acid) is a transient actor, but without CA it is not and can accumulate, so the pKa is not 6.1. - Bicarbonate secretion - Type B intercalated cells - H-ATPase polarity reversed - HCO3 Cl exchanger faces the apical rather than basolateral membrane- Titratable acidity - Weak acids are filtered at the glom and act as buffers in the urine. - HPO4 has PKA of 6.8 making it ideal - Creatinine (pKa 4.97) and uric acid (pKa 5.75) also contribute - Under normal cinditions TA buffers 10-40 mEa of H per day - Does an example of HPO4(2-):H2PO4 (1-) which exists 4:1 at pH of 7.4 (glomerular filtrate) - So for 50 mEq of Phos 40 is HPO4 and 10 is H2PO4 - When pH drops to 6.8 then the ratio is 1:1 so for 50 - So the 50 mEq is 25 and 25, so this buffered an additional 15 mEq of H while the free H+ concentration increased from 40 to 160 nanomol/L so over 99.99% of secreted H was buffered - When pH drops to 4.8 ratio is 1:100 so almost all 50 mEq of phos is H2PO4 and 39.5 mEq of H are buffered. - Acid loading decreases phosphate reabsorption so more is there to act as TA. - Decreases activity of Na-phosphate cotransporter - DKA provides a novel weak acid/buffer beta-hydroxybutyrate (pKa 4.8) which buffers significant amount of acid (50 mEq/d).- Ammonium Excretion - Ability to excrete H+ as ammonium ions adds an important amount of flexibility to renal acid-base regulation - NH3 and NH4 production and excretion can be varied according to physiologic need. - Starts with NH3 production in tubular cells - NH3, since it is neutral then diffuses into the tubule where it is acidified by the low pH to NH4+ - NH4+ is ionized and cannot cross back into the tubule cells(it is trapped in the tubular fluid) - This is important for it acting as an important buffer eve though the pKa is 9.0 - At pH of 6.0 the ratio of NH3 to NH4 is 1:1000 - As the neutral NH3 is converted to NH4 more NH3 from theintracellular compartment flows into the tubular fluid replacing the lost NH3. Rinse wash repeat. - This is an over simplification and that there are threemajor steps - NH4 is produced in early proximal tubular cells - Luminal NH4 is partially reabsorbed in the TAL and theNH3 is then recycled within the renal medulla - The medullary interstitial NH3 reaches highconcentrations that allow NH3 to diffuse into the tubular lumen in the medullary collecting tubule where it is trapped as NH4 by secreted H+ - NH4 production from Glutamine which converts to NH4 and glutamate - Glutamate is converted to alpha-ketoglutarate - Alpha ketoglutarate is converted to 2 HCO3 ions - HCO3 sent to systemic circulation by Na-3 HCO3 transporter - NH4 then secreted via Na-H exchanger into the lumen - NH4 is then reabsorbed by NaK2Cl transporter in TAL - NH4 substitutes for K - Once reabsorbed the higher intracellular pH causes NH4 to convert to NH3 and the H that is removed is secreted through Na-H exchanger to scavenge the last of the filtered bicarb. - NH3 diffuses out of the tubular cells into the interstitium - NH4 reabsorption in the TAL is suppressed by hyperkalemia and stimulated by chronic metabolic acidosis - NH4 recycling promotes acid clearance - The collecting tubule has a very low NH3 concentration - This promotes diffusion of NH3 into the collecting duct - NH3 that goes there is rapidly converted to NH4 allowing more NH3 to diffuse in. - Response to changes in pH - Increased ammonium excretion with two processes - Increased proximal NH4 production - This is delayed 24 hours to 2-3 days depending on which enzyme you look at - Decreased urine pH increases diffusion of ammonia into the MCD - Occurs with in hours of an acid load - Peak ammonium excretion takes 5-6 days! (Fig 11-10) - Glutamine is picked up from tubular fluid but with acidosis get Na dependent peritublar capillary glutamine scavenging too - Glutamine metabolism is pH dependent with increase with academia and decrease with alkalemia - NH4 excretion can go from 30-40 mEq/day to > 300 with severe metabolic acidosis (38 NaBicarb tabs) - Says each NH4 produces equimolar generation of HCO3 but I thought it was two bicarb for every alpha ketoglutarate?- The importance of urine pH - Though the total amount of hydrogren cleared by urine pH is insignificant, an acidic urine pH is essential for driving the reactions of TA and NH4 forward.- Regulation of renal hydrogen excretion - Net acid excretion vary inverse with extracellular pH - Academia triggers proximal and distal acidification - Proximally this: - Increased Na-H exchange - Increased luminal H-ATPase activity - Increased Na:3HCO3 cotransporter on the basolateral membrane - Increased NH4 production from glutamine - In the collecting tubules - Increased H-ATPase - Reduction of tubular pH promotes diffusion of NH3 which gets converted to NH4…ION TRAPPING - Extracellular pH affects net acid excretion through its affect on intracellular pH - This happens directly with respiratory disorders due to movement of CO2 through the lipid bilayer - In metabolic disorders a low extracellular bicarb with cause bicarb to diffuse out of the cell passively, this lowers intracellular pH - If you manipulate both low pCO2 and low Bicarb to keep pH stable there will be no change in the intracellular pH and there is no change in renal handling of acid. It is intracellular pH dependent - Metabolic acidosis - Ramps up net acid secretion - Starts within 24 hours and peaks after 5-6 days - Increase net secretion comes from NH4 - Phosphate is generally limited by diet - in DKA titratable acid can be ramped up - Metabolic alkalosis - Alkaline extracellular pH - Increased bicarb excretion - Decrease reabsorption - HCO3 secretion (pendrin) in cortical collecting tubule - Occurs in cortical intercalated cells able to insert H-ATPase in basolateral cells (rather than luminal membrane) - Normal subjects are able to secrete 1000 mmol/day of bicarb - Maintenance of metabolic alkalosis requires a defect which forces the renal resorption of bicarb - This can be chloride/volume deficiency - Hypokalemia - Hyperaldosteronism - Respiratory acidosis and alkalosis - PCO2 via its effect on intracellular pH is an important determinant of renal acid handling - Ratios he uses: - 3.5 per 10 for respiratory acidosis - 5 per 10 for respiratory alkalosis - Interesting paragraph contrasting the response to chronic metabolic acidosis vs chronic respiratory acidosis - Less urinary ammonium in respiratory acidosis - Major differences in proximal tubule cell pH - In metabolic acidosis there is decreased bicarb load so less to be reabsorbed proximally - In respiratory acidosis the increased serum bicarb increases the amount of bicarb that must be reabsorbed proximally - The increased activity of Na-H antiporter returns tubular cell pH to normal and prevents it from creating increased urinary ammonium - Mentions that weirdly more mRNA for H-Na antiporter in metabolic acidosis than in respiratory acidosis - Net hydrogen excretion varies with effective circulating volume - Starts with bicarb infusions - Normally Tm at 26 - But if you volume deplete the patient with diuretics first this increases to 35+ - Four factors explain this increased Tm for bicarb with volume deficiency - Reduced GFR - Activation of RAAS - Ang2 stim H-Na antiporter proximally - Ang2 also stimulates Na-3HCO3 cotransporter on basolateral membrane - Aldosterone stimulates H-ATPase in distal nephron - ALdo stimulates Cl HCO3 exchanger on basolateral membrane - Aldo stimulates eNaC producing tubular lumen negative charge to allow H secretion to occur and prevents back diffusion - Hypochloremia - Increases H secretion by both Na-dependent and Na-independent methods - If Na is 140 and Cl is 115, only 115 of Na can be reabsorbed as NaCl, the remainder must be reabsorbed with HCO3 or associated with secretion of K or H to maintained electro neutrality - This is enhanced with hypochloridemia - Concurrent hypokalemia - Changes in K lead to trans cellular shifts that affect inctracellular pH - Hypokalemia causes K out, H in and in the tubular cell the cell acts if there is systemic acidosis and increases H secretion (and bicarbonate resorption) - PTH - Decreases proximal HCO3 resorption - Primary HyperCard as cause of type 2 RTA - Does acidosis stim PTH or does PTH stim net acid excretion

Dr. Alexis Cowan shares tips about how to improve your gut health and thus metabolic health on a low-carb diet.  Support your Intermittent Fasting lifestyle with the Berberine Fasting Accelerator  by MYOXCIENCE: https://bit.ly/berberine-fasting-accelerator Use code podcast at checkout to save Link to Full Video Interview: https://youtu.be/2d__LLb6iwg Connect with Alexis: https://www.instagram.com/dralexisjazmyn/?hl=en Show Notes:  01:50 Your body maintains flux through all metabolic pathways for rapid adaption should the fuel source change.  06:54 Glycerol contributes to glucose production in your liver when you are keto. 07:20 Your neurotransmitters are either made from amino acids or they are amino acids.   09:55 Glutamate can be directly made into GABA.  11:20 Serotonin levels do not correlate with depression. 14:25 Some SSRI's directly modulate the microbiome.  15:40 Groups of microbes within the gut make lipid amides that interact with peripheral nerves to stimulate the release of dopamine in the area of the brain the encourages movement.  18:45 Human milk oligosaccharides are a potent food source of bifidobacterium.  21:25 Your colon is supposed to be low oxygen.  30:30 During exercise, changes in blood flow can promote the growth of bacteria. 33:12 Regular exercise shifts your immune response to be more anti-inflammatory. 34:45 Carnivore diet, done short term, is beneficial.  39:01 A high fermented food diet is more effective than a high fiber diet.  43:00 Independent scientists in independent labs require crowd or private funding. 46:20 The biggest cause of cavities is dry mouth.  48:30 Using antiseptic mouthwash, can acutely influence exercise performance.  50:00 Ground meat protein is more bioavailable than eating a whole cut of meat.  50:30 There is a connection between antiseptic mouthwash and erectile dysfunction.   

Our guest this week, Matt Gallant, spent $45,000 to optimize his sleep and is sharing what he learned with us. 67% of Americans report frequent sleep issues and 43% say that these sleep issues impact their daily activities. Sleep deprivation and poor quality sleep are major issues today, primarily due to the 7 sleep disruptors Matt has discovered. He shares his top biohacks to overcome these disruptors, the pros and cons of sleep trackers, what you need to know about melatonin, and a deep dive into the top sleep nutrients that went into his latest sleep formula. Matt Gallant is the CEO and Co-Founder of BiOptimizers and has a bachelor's degree in Kinesiology. He's been a strength and conditioning coach for multiple pro athletes, and a self-defense instructor, and has over 15 years of experience formulating supplements. He's also a serial entrepreneur that's built over 13 profitable companies. SHOW NOTES:0:51 Welcome to the show!5:02 Matt Gallant's Bio5:25 Welcome Matt6:28 Why is sleep so important?9:22 Sleep Disruptor #1: Light & Darkness13:19 The dangers of light at night15:32 More on light & melatonin18:19 Sleep Disruptor #2: Temperature24:33 *SilverBiotics*26:08 Sleep Disruptor #3: Eating late at night30:58 His thoughts on sleep trackers35:18 *Sleep Breakthrough*37:12 Sleep Disruptor #4: Blood flow constriction40:15 How did our ancestors sleep?42:00 Sleep Disruptor #5: Oxygen & Hypoxia 45:35 Sleep Disruptor #6: Consistency & early sleep48:25 The science behind different sleep molecules & ingredients56:57 GABA, Glutamate & Genetics58:46 How they create new supplement formulas1:01:52 New Dream Optimizer sleep spray 1:05:38 His final piece of advice1:09:52 What's coming soon from BiOptimizers1:12:21 Thanks for tuning in! RESOURCES:BB 7-Day ChallengeReTimer Light Therapy GlassesHuman ChargerVerilux Happy (SAD) LightChiliSleep PodEight Sleep Pod & Mattress – code: BIOHACKERBABESManta Sleep eye maskBiOptimizers Magnesium BreakthroughSilverBiotics – code: BIOHACKERBABESSleep Breakthrough Powder - code: biohackerbabes10Kion Aminos – code: BIOBABESDreem headsetEssentia mattresshttps://elanra.comHypoAir Air Purifier - code: BIOHACKERBABESNanoVi - the secret to reversing Oxidative StressSleep Chronotype QuizSupport this podcast at — https://redcircle.com/biohacker-babes-podcast/donationsAdvertising Inquiries: https://redcircle.com/brands

ReferencesWe considered the effect of a high protein diet and potential metabolic acidosis on kidney function. This review is of interest by Donald Wesson, a champion for addressing this issue and limiting animal protein: Mechanisms of Metabolic Acidosis-Induced Kidney Injury in Chronic Kidney DiseaseHostetter explored the effect of a high protein diet in the remnant kidney model with 1 ¾ nephrectomy. Rats with reduced dietary acid load (by bicarbonate supplementation) had less tubular damage. Chronic effects of dietary protein in the rat with intact and reduced renal massWesson explored treatment of metabolic acidosis in humans with stage 3 CKD in this study. Treatment of metabolic acidosis in patients with stage 3 chronic kidney disease with fruits and vegetables or oral bicarbonate reduces urine angiotensinogen and preserves glomerular filtration rateIn addition to the effect of metabolic acidosis from a diet high in animal protein, this diet also leads to hyperfiltration. This was demonstrated in normal subjects; ingesting a protein diet had a significantly higher creatinine clearance than a comparable group of normal subjects ingesting a vegetarian diet. Renal functional reserve in humans: Effect of protein intake on glomerular filtration rate.This finding has been implicated in Brenner's theory regarding hyperfiltration: The hyperfiltration theory: a paradigm shift in nephrologyOne of multiple publications from Dr. Nimrat Goraya whom Joel mentioned in the voice over: Dietary Protein as Kidney Protection: Quality or Quantity?We wondered about the time course in buffering a high protein meal (and its subsequent acid load on ventilation) and Amy found this report:Effect of Protein Intake on Ventilatory Drive | Anesthesiology | American Society of Anesthesiologists Roger mentioned that the need for acetate to balance the acid from amino acids in parenteral nutrition was identified in pediatrics perhaps because infants may have reduced ability to generate acid. Randomised controlled trial of acetate in preterm neonates receiving parenteral nutrition - PMCHe also recommended an excellent review on the complications of parenteral nutrition by Knochel https://www.kidney-international.org/action/showPdf?pii=S0085-2538%2815%2933384-6 which explained that when the infused amino acids disproportionately include cationic amino acids, metabolism led to H+ production. This is typically mitigated by preparing a solution that is balanced by acetate. Amy mentioned this study that explored the effect of protein intake on ventilation: Effect of Protein Intake on Ventilatory Drive | Anesthesiology | American Society of AnesthesiologistsAnna and Amy reminisced about a Skeleton Key Group Case from the renal fellow network Skeleton Key Group: Electrolyte Case #7JC wondered about isolated defects in the proximal tubule and an example is found here: Mutations in SLC4A4 cause permanent isolated proximal renal tubular acidosis with ocular abnormalitiesAnna's Voiceover re: Gastric neobladder → metabolic alkalosis and yes, dysuria. The physiology of gastrocystoplasty: once a stomach, always a stomach but not as common as you might think Gastrocystoplasty: long-term complications in 22 patientsSjögren's syndrome has been associated with acquired distal RTA and in some cases, an absence of the H+ ATPase, presumably from autoantibodies to this transporter. Here's a case report: Absence of H(+)-ATPase in cortical collecting tubules of a patient with Sjogren's syndrome and distal renal tubular acidosisCan't get enough disequilibrium pH? Check this out- Spontaneous luminal disequilibrium pH in S3 proximal tubules. Role in ammonia and bicarbonate transport.Acetazolamide secretion was studied in this report Concentration-dependent tubular secretion of acetazolamide and its inhibition by salicylic acid in the isolated perfused rat kidney. | Drug Metabolism & DispositionIn this excellent review, David Goldfarb tackles the challenging case of a A Woman with Recurrent Calcium Phosphate Kidney Stones (spoiler alert, many of these patients have incomplete distal RTA and this problem is hard to treat). Molecular mechanisms of renal ammonia transport excellent review from David Winer and Lee Hamm. OutlineOutline: Chapter 11- Regulation of Acid-Base Balance- Introduction - Bicarb plus a proton in equilibrium with CO2 and water - Can be rearranged to HH - Importance of regulating pCO2 and HCO3 outside of this equation - Metabolism of carbs and fats results in the production of 15,000 mmol of CO2 per day - Metabolism of protein and other “substances” generates non-carbonic acids and bases - Mostly from sulfur containing methionine and cysteine - And cationic arginine and lysine - Hydrolysis of dietary phosphate that exists and H2PO4– - Source of base/alkali - Metabolism of an ionic amino acids - Glutamate and asparatate - Organic anions going through gluconeogenesis - Glutamate, Citrate and lactate - Net effect on a normal western diet 50-100 mEq of H+ per day - Homeostatic response to these acid-base loads has three stages: - Chemical buffering - Changes in ventilation - Changes in H+ excretion - Example of H2SO4 from oxidation of sulfur containing AA - Drop in bicarb will stimulate renal acid secretion - Nice table of normal cid-base values, arterial and venous- Great 6 bullet points of acid-base on page 328 - Kidneys must excrete 50-100 of non-carbonic acid daily - This occurs by H secretion, but mechanisms change by area of nephron - Not excreted as free H+ due to minimal urine pH being equivalent to 0.05 mmol/L - No H+ can be excreted until virtually all of th filtered bicarb is reabsorbed - Secreted H+ must bind buffers (phosphate, NH3, cr) - PH is main stimulus for H secretion, though K, aldo and volume can affect this.- Renal Hydrogen excretion - Critical to understand that loss of bicarb is like addition of hydrogen to the body - So all bicarb must be reabsorbed before dietary H load can be secreted - GFR of 125 and bicarb of 24 results in 4300 mEq of bicarb to be reabsorbed daily - Reabsorption of bicarb and secretion of H involve H secretion from tubular cells into the lumen. - Thee initial points need to be emphasized - Secreted H+ ion are generated from dissociation of H2O - Also creates OH ion - Which combine with CO2 to form HCO3 with the help of zinc containing intracellular carbonic anhydrase. - This is how the secretion of H+ which creates an OH ultimately produces HCO3 - Different mechanisms for proximal and distal acidification - NET ACID EXCRETION - Free H+ is negligible - So net H+ is TA + NH4 – HCO3 loss - Unusually equal to net H+ load, 50-100 mEq/day - Can bump up to 300 mEq/day if acid production is increased - Net acid excretion can go negative following a bicarb or citrate load - Proximal Acidification - Na-H antiporter (or exchanger) in luminal membrane - Basolateral membrane has a 3 HCO3 Na cotransporter - This is electrogenic with 3 anions going out and only one cation - The Na-H antiporter also works in the thick ascending limb of LOH - How about this, there is also a H-ATPase just like found in the intercalated cells in the proximal tubule and is responsible for about a third of H secretion - And similarly there is also. HCO3 Cl exchanger (pendrin-like) in the proximal tubule - Footnote says the Na- 3HCO3 cotransporter (which moves sodium against chemical gradient NS uses negative charge inside cell to power it) is important for sensing acid-base changes in the cell. - Distal acidification - Occurs in intercalated cells of of cortical and medullary collecting tubule - Three main characteristics - H secretion via active secretory pumps in the luminal membrane - Both H-ATPase and H-K ATPase - H- K ATPase is an exchange pump, k reabsorption - H-K exchange may be more important in hypokalemia rather than in acid-base balance - Whole paragraph on how a Na-H exchanger couldn't work because the gradient that H has to be pumped up is too big. - H-ATPase work like vasopressin with premise H-ATPase sitting on endocarditis vesicles a=which are then inserted into the membrane. Alkalosis causes them to be recycled out of the membrane. - H secretory cells do not transport Na since they have few luminal Na channels, but are assisted by the lumen negative tubule from eNaC. - Minimizes back diffusion of H+ and promotes bicarb resorption - Bicarbonate leaves the cell through HCO3-Cl exchanger which uses the low intracellular Cl concentration to power this process. - Same molecule is found on RBC where it is called band 3 protein - Figure 11-5 is interesting - Bicarbonate resorption - 90% in the first 1-22 mm of the proximal tubule (how long is the proximal tubule?) - Lots of Na-H exchangers and I handed permeability to HCO3 (permeability where?) - Last 10% happens distally mostly TAL LOH via Na-H exchange - And the last little bit int he outer medullary collecting duct. - Carbonic anhydrase and disequilibrium pH - CA plays central role in HCO3 reabsorption - After H is secreted in the proximal tubule it combines with HCO# to form carbonic acid. CA then dehydrates it to CO2 and H2O. (Step 2) - Constantly moving carbonic acid to CO2 and H2O keeps hydrogen combining with HCO3 since the product is rapidly consumed. - This can be demonstrated by the minimal fall in luminal pH - That is important so there is not a luminal gradient for H to overcome in the Na-H exchanger (this is why we need a H-ATPase later) - CA inhibitors that are limited tot he extracellular compartment can impair HCO3 reabsorption by 80%. - CA is found in S1, S2 but not S3 segment. See consequence in figure 11-6. - The disequilibrium comes from areas where there is no CA, the HH formula falls down because one of the assumptions of that formula is that H2CO3 (carbonic acid) is a transient actor, but without CA it is not and can accumulate, so the pKa is not 6.1. - Bicarbonate secretion - Type B intercalated cells - H-ATPase polarity reversed - HCO3 Cl exchanger faces the apical rather than basolateral membrane- Titratable acidity - Weak acids are filtered at the glom and act as buffers in the urine. - HPO4 has PKA of 6.8 making it ideal - Creatinine (pKa 4.97) and uric acid (pKa 5.75) also contribute - Under normal cinditions TA buffers 10-40 mEa of H per day - Does an example of HPO4(2-):H2PO4 (1-) which exists 4:1 at pH of 7.4 (glomerular filtrate) - So for 50 mEq of Phos 40 is HPO4 and 10 is H2PO4 - When pH drops to 6.8 then the ratio is 1:1 so for 50 - So the 50 mEq is 25 and 25, so this buffered an additional 15 mEq of H while the free H+ concentration increased from 40 to 160 nanomol/L so over 99.99% of secreted H was buffered - When pH drops to 4.8 ratio is 1:100 so almost all 50 mEq of phos is H2PO4 and 39.5 mEq of H are buffered. - Acid loading decreases phosphate reabsorption so more is there to act as TA. - Decreases activity of Na-phosphate cotransporter - DKA provides a novel weak acid/buffer beta-hydroxybutyrate (pKa 4.8) which buffers significant amount of acid (50 mEq/d).- Ammonium Excretion - Ability to excrete H+ as ammonium ions adds an important amount of flexibility to renal acid-base regulation - NH3 and NH4 production and excretion can be varied according to physiologic need. - Starts with NH3 production in tubular cells - NH3, since it is neutral then diffuses into the tubule where it is acidified by the low pH to NH4+ - NH4+ is ionized and cannot cross back into the tubule cells(it is trapped in the tubular fluid) - This is important for it acting as an important buffer eve though the pKa is 9.0 - At pH of 6.0 the ratio of NH3 to NH4 is 1:1000 - As the neutral NH3 is converted to NH4 more NH3 from theintracellular compartment flows into the tubular fluid replacing the lost NH3. Rinse wash repeat. - This is an over simplification and that there are threemajor steps - NH4 is produced in early proximal tubular cells - Luminal NH4 is partially reabsorbed in the TAL and theNH3 is then recycled within the renal medulla - The medullary interstitial NH3 reaches highconcentrations that allow NH3 to diffuse into the tubular lumen in the medullary collecting tubule where it is trapped as NH4 by secreted H+ - NH4 production from Glutamine which converts to NH4 and glutamate - Glutamate is converted to alpha-ketoglutarate - Alpha ketoglutarate is converted to 2 HCO3 ions - HCO3 sent to systemic circulation by Na-3 HCO3 transporter - NH4 then secreted via Na-H exchanger into the lumen - NH4 is then reabsorbed by NaK2Cl transporter in TAL - NH4 substitutes for K - Once reabsorbed the higher intracellular pH causes NH4 to convert to NH3 and the H that is removed is secreted through Na-H exchanger to scavenge the last of the filtered bicarb. - NH3 diffuses out of the tubular cells into the interstitium - NH4 reabsorption in the TAL is suppressed by hyperkalemia and stimulated by chronic metabolic acidosis - NH4 recycling promotes acid clearance - The collecting tubule has a very low NH3 concentration - This promotes diffusion of NH3 into the collecting duct - NH3 that goes there is rapidly converted to NH4 allowing more NH3 to diffuse in. - Response to changes in pH - Increased ammonium excretion with two processes - Increased proximal NH4 production - This is delayed 24 hours to 2-3 days depending on which enzyme you look at - Decreased urine pH increases diffusion of ammonia into the MCD - Occurs with in hours of an acid load - Peak ammonium excretion takes 5-6 days! (Fig 11-10) - Glutamine is picked up from tubular fluid but with acidosis get Na dependent peritublar capillary glutamine scavenging too - Glutamine metabolism is pH dependent with increase with academia and decrease with alkalemia - NH4 excretion can go from 30-40 mEq/day to > 300 with severe metabolic acidosis (38 NaBicarb tabs) - Says each NH4 produces equimolar generation of HCO3 but I thought it was two bicarb for every alpha ketoglutarate?- The importance of urine pH - Though the total amount of hydrogren cleared by urine pH is insignificant, an acidic urine pH is essential for driving the reactions of TA and NH4 forward.- Regulation of renal hydrogen excretion - Net acid excretion vary inverse with extracellular pH - Academia triggers proximal and distal acidification - Proximally this: - Increased Na-H exchange - Increased luminal H-ATPase activity - Increased Na:3HCO3 cotransporter on the basolateral membrane - Increased NH4 production from glutamine - In the collecting tubules - Increased H-ATPase - Reduction of tubular pH promotes diffusion of NH3 which gets converted to NH4…ION TRAPPING - Extracellular pH affects net acid excretion through its affect on intracellular pH - This happens directly with respiratory disorders due to movement of CO2 through the lipid bilayer - In metabolic disorders a low extracellular bicarb with cause bicarb to diffuse out of the cell passively, this lowers intracellular pH - If you manipulate both low pCO2 and low Bicarb to keep pH stable there will be no change in the intracellular pH and there is no change in renal handling of acid. It is intracellular pH dependent - Metabolic acidosis - Ramps up net acid secretion - Starts within 24 hours and peaks after 5-6 days - Increase net secretion comes from NH4 - Phosphate is generally limited by diet - in DKA titratable acid can be ramped up - Metabolic alkalosis - Alkaline extracellular pH - Increased bicarb excretion - Decrease reabsorption - HCO3 secretion (pendrin) in cortical collecting tubule - Occurs in cortical intercalated cells able to insert H-ATPase in basolateral cells (rather than luminal membrane) - Normal subjects are able to secrete 1000 mmol/day of bicarb - Maintenance of metabolic alkalosis requires a defect which forces the renal resorption of bicarb - This can be chloride/volume deficiency - Hypokalemia - Hyperaldosteronism - Respiratory acidosis and alkalosis - PCO2 via its effect on intracellular pH is an important determinant of renal acid handling - Ratios he uses: - 3.5 per 10 for respiratory acidosis - 5 per 10 for respiratory alkalosis - Interesting paragraph contrasting the response to chronic metabolic acidosis vs chronic respiratory acidosis - Less urinary ammonium in respiratory acidosis - Major differences in proximal tubule cell pH - In metabolic acidosis there is decreased bicarb load so less to be reabsorbed proximally - In respiratory acidosis the increased serum bicarb increases the amount of bicarb that must be reabsorbed proximally - The increased activity of Na-H antiporter returns tubular cell pH to normal and prevents it from creating increased urinary ammonium - Mentions that weirdly more mRNA for H-Na antiporter in metabolic acidosis than in respiratory acidosis - Net hydrogen excretion varies with effective circulating volume - Starts with bicarb infusions - Normally Tm at 26 - But if you volume deplete the patient with diuretics first this increases to 35+ - Four factors explain this increased Tm for bicarb with volume deficiency - Reduced GFR - Activation of RAAS - Ang2 stim H-Na antiporter proximally - Ang2 also stimulates Na-3HCO3 cotransporter on basolateral membrane - Aldosterone stimulates H-ATPase in distal nephron - ALdo stimulates Cl HCO3 exchanger on basolateral membrane - Aldo stimulates eNaC producing tubular lumen negative charge to allow H secretion to occur and prevents back diffusion - Hypochloremia - Increases H secretion by both Na-dependent and Na-independent methods - If Na is 140 and Cl is 115, only 115 of Na can be reabsorbed as NaCl, the remainder must be reabsorbed with HCO3 or associated with secretion of K or H to maintained electro neutrality - This is enhanced with hypochloridemia - Concurrent hypokalemia - Changes in K lead to trans cellular shifts that affect inctracellular pH - Hypokalemia causes K out, H in and in the tubular cell the cell acts if there is systemic acidosis and increases H secretion (and bicarbonate resorption) - PTH - Decreases proximal HCO3 resorption - Primary HyperCard as cause of type 2 RTA - Does acidosis stim PTH or does PTH stim net acid excretion

GET TRANSCRIPT AND FULL SHOWNOTES: melanieavalon.com/fastinghistory 2:15 - IF Biohackers: Intermittent Fasting + Real Foods + Life: Join Melanie's Facebook Group At Facebook.com/groups/paleoOMAD For A Weekly Episode GIVEAWAY, And To Discuss And Learn About All Things Biohacking! All Conversations Welcome! 2:30 - Follow Melanie On Instagram To See The Latest Moments, Products, And #AllTheThings! @MelanieAvalon 3:00 - AVALONX SUPPLEMENTS: AvalonX Supplements Are Free Of Toxic Fillers And Common Allergens (Including Wheat, Rice, Gluten, Dairy, Shellfish, Nuts, Soy, Eggs, And Yeast), Tested To Be Free Of Heavy Metals And Mold, And Triple Tested For Purity And Potency. Get On The Email List To Stay Up To Date With All The Special Offers And News About Melanie's New Supplements At avalonx.us/emaillist! Get 10% Off Serrapeptase 125, Magnesium 8 AND Berberine 500 At avalonx.us And mdlogichealth.com With The Code MelanieAvalon!   Text AVALONX To 877-861-8318 For A One Time 20% Off Code for avalonx.us! 5:35 - FOOD SENSE GUIDE: Get Melanie's App At Melanieavalon.com/foodsenseguide To Tackle Your Food Sensitivities! Food Sense Includes A Searchable Catalogue Of 300+ Foods, Revealing Their Gluten, FODMAP, Lectin, Histamine, Amine, Glutamate, Oxalate, Salicylate, Sulfite, And Thiol Status. Food Sense Also Includes Compound Overviews, Reactions To Look For, Lists Of Foods High And Low In Them, The Ability To Create Your Own Personal Lists, And More! 6:15 - BEAUTYCOUNTER: Non-Toxic Beauty Products Tested For Heavy Metals, Which Support Skin Health And Look Amazing! Shop At beautycounter.com/melanieavalon For Something Magical! For Exclusive Offers And Discounts, And More On The Science Of Skincare, Get On Melanie's Private Beautycounter Email List At Melanieavalon.Com/Cleanbeauty Or Text BEAUTYCOUNTER To 877-861-8318! Find Your Perfect Beautycounter Products With Melanie's Quiz: melanieavalon.com/beautycounterquiz 10:35 - The Research That Went Into The Book 13:30 - Steve's Personal Story 18:30 - Dr. Henry Tanner, The Father Of Fasting 26:25 - Why Don't Doctors Believe In The Power Of Fasting? 28:45 - HOLDON BAGS: Reduce Single-Use Plastic! HoldOn Makes Heavy Duty, Plant-Based, Nontoxic And 100% Home Compostable Trash, Bags, Sandwich Bags, And Gallon Bags To Help Combat Our Toxic Plastic Environment! Sustainability Has Never Been More Simple! Visit Holdonbags.Com/MELANIEAVALON And Enter Code MELANIEAVALON At Checkout To Save 20% Off Your Order! 31:50 - Heroic Medicine 35:45 - Historical Theories About Endogenous Energy Sources During Fasting 38:00 - Why Didn't People Notice It Was Fat That Was Being Burnt For Energy? 40:00 - Fasting In Greek History 46:35 - How Do We Know These Famous Quotes Aren't Real? 49:00 - Fasting In Religion 52:45 - Women Taking On The Role Of Fasting  59:50 - The Oppression Of Women Through Diet Control 1:02:40 - LOMI: Turn Your Kitchen Scraps Into Dirt, To Reduce Waste, Add Carbon Back To The Soil, And Support Sustainability! Get $50 Off Lomi At lomi.com/melanieavalon With The Code MELANIEAVALON! 1:05:35 - Jainism 1:09:20 - Dying Of Starvation 1:11:15 - The Loss Of Fasting In Christianity And The Creation Of Lent 1:20:00 - Bernarr Macfadden 1:26:30 - Upton Sinclair 1:33:40 - The Dismissal Of Fasting In Modern Medicine 1:36:00 - LMNT: For Fasting Or Low-Carb Diets Electrolytes Are Key For Relieving Hunger, Cramps, Headaches, Tiredness, And Dizziness. With No Sugar, Artificial Ingredients, Coloring, And Only 2 Grams Of Carbs Per Packet, Try LMNT For Complete And Total Hydration. For A Limited Time Go To drinklmnt.com/melanieavalon To Get A Sample Pack With Any Purchase! 1:39:05 - "Tricking" People Into Fasting 1:40:50 - Valter Longo And Fasting Mimicking Diet 1:47:30 - Fasting Clinics 1:50:30 - Alan Goldhamer's Data On Blood Pressure  1:54:30 - Steve's Experience At The Clinic 1:57:45 - The Future Of Fasting 2:01:05 - Steve's Fasting Practices

GET TRANSCRIPT AND FULL SHOWNOTES: melanieavalon.com/fastinghistory 2:15 - IF Biohackers: Intermittent Fasting + Real Foods + Life: Join Melanie's Facebook Group At Facebook.com/groups/paleoOMAD For A Weekly Episode GIVEAWAY, And To Discuss And Learn About All Things Biohacking! All Conversations Welcome! 2:30 - Follow Melanie On Instagram To See The Latest Moments, Products, And #AllTheThings! @MelanieAvalon 3:00 - AVALONX SUPPLEMENTS: AvalonX Supplements Are Free Of Toxic Fillers And Common Allergens (Including Wheat, Rice, Gluten, Dairy, Shellfish, Nuts, Soy, Eggs, And Yeast), Tested To Be Free Of Heavy Metals And Mold, And Triple Tested For Purity And Potency. Get On The Email List To Stay Up To Date With All The Special Offers And News About Melanie's New Supplements At avalonx.us/emaillist! Get 10% Off Serrapeptase 125, Magnesium 8 AND Berberine 500 At avalonx.us And mdlogichealth.com With The Code MelanieAvalon!   Text AVALONX To 877-861-8318 For A One Time 20% Off Code for avalonx.us! 5:35 - FOOD SENSE GUIDE: Get Melanie's App At Melanieavalon.com/foodsenseguide To Tackle Your Food Sensitivities! Food Sense Includes A Searchable Catalogue Of 300+ Foods, Revealing Their Gluten, FODMAP, Lectin, Histamine, Amine, Glutamate, Oxalate, Salicylate, Sulfite, And Thiol Status. Food Sense Also Includes Compound Overviews, Reactions To Look For, Lists Of Foods High And Low In Them, The Ability To Create Your Own Personal Lists, And More! 6:15 - BEAUTYCOUNTER: Non-Toxic Beauty Products Tested For Heavy Metals, Which Support Skin Health And Look Amazing! Shop At beautycounter.com/melanieavalon For Something Magical! For Exclusive Offers And Discounts, And More On The Science Of Skincare, Get On Melanie's Private Beautycounter Email List At Melanieavalon.Com/Cleanbeauty Or Text BEAUTYCOUNTER To 877-861-8318! Find Your Perfect Beautycounter Products With Melanie's Quiz: melanieavalon.com/beautycounterquiz 10:35 - The Research That Went Into The Book 13:30 - Steve's Personal Story 18:30 - Dr. Henry Tanner, The Father Of Fasting 26:25 - Why Don't Doctors Believe In The Power Of Fasting? 28:45 - HOLDON BAGS: Reduce Single-Use Plastic! HoldOn Makes Heavy Duty, Plant-Based, Nontoxic And 100% Home Compostable Trash, Bags, Sandwich Bags, And Gallon Bags To Help Combat Our Toxic Plastic Environment! Sustainability Has Never Been More Simple! Visit Holdonbags.Com/MELANIEAVALON And Enter Code MELANIEAVALON At Checkout To Save 20% Off Your Order! 31:50 - Heroic Medicine 35:45 - Historical Theories About Endogenous Energy Sources During Fasting 38:00 - Why Didn't People Notice It Was Fat That Was Being Burnt For Energy? 40:00 - Fasting In Greek History 46:35 - How Do We Know These Famous Quotes Aren't Real? 49:00 - Fasting In Religion 52:45 - Women Taking On The Role Of Fasting  59:50 - The Oppression Of Women Through Diet Control 1:02:40 - LOMI: Turn Your Kitchen Scraps Into Dirt, To Reduce Waste, Add Carbon Back To The Soil, And Support Sustainability! Get $50 Off Lomi At lomi.com/melanieavalon With The Code MELANIEAVALON! 1:05:35 - Jainism 1:09:20 - Dying Of Starvation 1:11:15 - The Loss Of Fasting In Christianity And The Creation Of Lent 1:20:00 - Bernarr Macfadden 1:26:30 - Upton Sinclair 1:33:40 - The Dismissal Of Fasting In Modern Medicine 1:36:00 - LMNT: For Fasting Or Low-Carb Diets Electrolytes Are Key For Relieving Hunger, Cramps, Headaches, Tiredness, And Dizziness. With No Sugar, Artificial Ingredients, Coloring, And Only 2 Grams Of Carbs Per Packet, Try LMNT For Complete And Total Hydration. For A Limited Time Go To drinklmnt.com/melanieavalon To Get A Sample Pack With Any Purchase! 1:39:05 - "Tricking" People Into Fasting 1:40:50 - Valter Longo And Fasting Mimicking Diet 1:47:30 - Fasting Clinics 1:50:30 - Alan Goldhamer's Data On Blood Pressure  1:54:30 - Steve's Experience At The Clinic 1:57:45 - The Future Of Fasting 2:01:05 - Steve's Fasting Practices  

SHOWNOTES GET TRANSCRIPT AND FULL SHOWNOTES: melanieavalon.com/immunesystem   1:50 - IF Biohackers: Intermittent Fasting + Real Foods + Life: Join Melanie's Facebook Group At Facebook.com/groups/paleoOMAD For A Weekly Episode GIVEAWAY, And To Discuss And Learn About All Things Biohacking! All Conversations Welcome! 2:00 - Follow Melanie On Instagram To See The Latest Moments, Products, And #AllTheThings! @MelanieAvalon 2:20 - AVALONX SUPPLEMENTS: AvalonX Supplements Are Free Of Toxic Fillers And Common Allergens (Including Wheat, Rice, Gluten, Dairy, Shellfish, Nuts, Soy, Eggs, And Yeast), Tested To Be Free Of Heavy Metals And Mold, And Triple Tested For Purity And Potency. Get On The Email List To Stay Up To Date With All The Special Offers And News About Melanie's New Supplements At avalonx.us/emaillist! Get 10% Off SERRAPEPTASE 125, MAGNESIUM 8 AND BERBERINE 500 At avalonx.us And mdlogichealth.com With The Code MelanieAvalon! New Customers Can Get 20% Off With Coupon Code  Text "AVALONX" To 877-861-8318 And New Customers Can Get 20% Off With A Coupon Code At avalonx.us! 4:30 - FOOD SENSE GUIDE: Get Melanie's App At Melanieavalon.com/foodsenseguide To Tackle Your Food Sensitivities! Food Sense Includes A Searchable Catalogue Of 300+ Foods, Revealing Their Gluten, FODMAP, Lectin, Histamine, Amine, Glutamate, Oxalate, Salicylate, Sulfite, And Thiol Status. Food Sense Also Includes Compound Overviews, Reactions To Look For, Lists Of Foods High And Low In Them, The Ability To Create Your Own Personal Lists, And More! 5:10 - BEAUTYCOUNTER: Non-Toxic Beauty Products Tested For Heavy Metals, Which Support Skin Health And Look Amazing! Shop At beautycounter.com/melanieavalon For Something Magical! For Exclusive Offers And Discounts, And More On The Science Of Skincare, Get On Melanie's Private Beautycounter Email List At Melanieavalon.Com/Cleanbeauty Or Text BEAUTYCOUNTER To 877-861-8318! Find Your Perfect Beautycounter Products With Melanie's Quiz: melanieavalon.com/beautycounterquiz Join Melanie's Facebook Group Clean Beauty And Safe Skincare With Melanie Avalon To Discuss And Learn About All The Things Clean Beauty, Beautycounter And Safe Skincare! 9:05 - Heather's Background 14:40 - The History Of Infectious Disease And The Changes In Our Understanding 19:20 - What Is Immunity To A Disease? 23:00 - BONCHARGE: Blue-Light Blocking Glasses For Sleep, Stress, And Health! Go To Boncharge.Com And Use The Code Melanieavalon For 15% Off! 25:55 - The Immune System 28:00 - Is There A Central Knowledge To The Immune System? 30:25 - Is Inflammation Always Involved In An Immune Response? 32:00 - Innate And Adaptive Immune Systems 35:05 - Autoimmune Activity 35:55 - B-Cells And T-Cells 37:55 - How B-Cells Attack Viruses 40:15 - How Do Antibodies Work? 41:40 - IgM And IgG Antibodies 43:05 - The Circadian Rhythm To The Immune System 46:15 - Sleep And Inflammation 47:35 - Sleep And Vaccines 49:15 - AIRDOCTOR: Clean Your Air Of Pollutants, Viruses, Dust, And Other Toxins (Including 99.97% Of Covid) At An Incredible Price! Shop At MelanieAvalon.com/AirDoctor For Up To 50% Off All AirDoctor Units!  51:40 - TH Cell Polarization 56:30 - Allergies 59:05 - How Early Do We Develop IgE Antibodies 59:50 - Colostrum 1:01:15 - T-Cells In The Thymus 1:02:30 - Identifying The 4 Immuno-Types 1:07:20 - Inflammation And CRP 1:09:10 - Conventional & Specialized Lab Tests 1:09:25 - BLISSY: Get Cooling, Comfortable, Sustainable Silk Pillowcases To Revolutionize Your Sleep, Skin, And Hair! Once You Get Silk Pillowcases, You Will Never Look Back! Get Blissy In Tons Of Colors, And Risk-Free For 60 Nights, At Blissy.Com/Melanieavalon, With The Code Melanieavalon For 30% Off! 1:12:55 - How To Truly Boost The Immune System 1:18:00 - Sex And The Immune System 1:20:25 - How To Repair The Immune System And How Long Does It Take

SHOWNOTES GET TRANSCRIPT AND FULL SHOWNOTES: melanieavalon.com/immunesystem   1:50 - IF Biohackers: Intermittent Fasting + Real Foods + Life: Join Melanie's Facebook Group At Facebook.com/groups/paleoOMAD For A Weekly Episode GIVEAWAY, And To Discuss And Learn About All Things Biohacking! All Conversations Welcome! 2:00 - Follow Melanie On Instagram To See The Latest Moments, Products, And #AllTheThings! @MelanieAvalon 2:20 - AVALONX SUPPLEMENTS: AvalonX Supplements Are Free Of Toxic Fillers And Common Allergens (Including Wheat, Rice, Gluten, Dairy, Shellfish, Nuts, Soy, Eggs, And Yeast), Tested To Be Free Of Heavy Metals And Mold, And Triple Tested For Purity And Potency. Get On The Email List To Stay Up To Date With All The Special Offers And News About Melanie's New Supplements At avalonx.us/emaillist! Get 10% Off SERRAPEPTASE 125, MAGNESIUM 8 AND BERBERINE 500 At avalonx.us And mdlogichealth.com With The Code MelanieAvalon! New Customers Can Get 20% Off With Coupon Code  Text "AVALONX" To 877-861-8318 And New Customers Can Get 20% Off With A Coupon Code At avalonx.us! 4:30 - FOOD SENSE GUIDE: Get Melanie's App At Melanieavalon.com/foodsenseguide To Tackle Your Food Sensitivities! Food Sense Includes A Searchable Catalogue Of 300+ Foods, Revealing Their Gluten, FODMAP, Lectin, Histamine, Amine, Glutamate, Oxalate, Salicylate, Sulfite, And Thiol Status. Food Sense Also Includes Compound Overviews, Reactions To Look For, Lists Of Foods High And Low In Them, The Ability To Create Your Own Personal Lists, And More! 5:10 - BEAUTYCOUNTER: Non-Toxic Beauty Products Tested For Heavy Metals, Which Support Skin Health And Look Amazing! Shop At beautycounter.com/melanieavalon For Something Magical! For Exclusive Offers And Discounts, And More On The Science Of Skincare, Get On Melanie's Private Beautycounter Email List At Melanieavalon.Com/Cleanbeauty Or Text BEAUTYCOUNTER To 877-861-8318! Find Your Perfect Beautycounter Products With Melanie's Quiz: melanieavalon.com/beautycounterquiz Join Melanie's Facebook Group Clean Beauty And Safe Skincare With Melanie Avalon To Discuss And Learn About All The Things Clean Beauty, Beautycounter And Safe Skincare! 9:05 - Heather's Background 14:40 - The History Of Infectious Disease And The Changes In Our Understanding 19:20 - What Is Immunity To A Disease? 23:00 - BONCHARGE: Blue-Light Blocking Glasses For Sleep, Stress, And Health! Go To Boncharge.Com And Use The Code Melanieavalon For 15% Off! 25:55 - The Immune System 28:00 - Is There A Central Knowledge To The Immune System? 30:25 - Is Inflammation Always Involved In An Immune Response? 32:00 - Innate And Adaptive Immune Systems 35:05 - Autoimmune Activity 35:55 - B-Cells And T-Cells 37:55 - How B-Cells Attack Viruses 40:15 - How Do Antibodies Work? 41:40 - IgM And IgG Antibodies 43:05 - The Circadian Rhythm To The Immune System 46:15 - Sleep And Inflammation 47:35 - Sleep And Vaccines 49:15 - AIRDOCTOR: Clean Your Air Of Pollutants, Viruses, Dust, And Other Toxins (Including 99.97% Of Covid) At An Incredible Price! Shop At MelanieAvalon.com/AirDoctor For Up To 50% Off All AirDoctor Units!  51:40 - TH Cell Polarization 56:30 - Allergies 59:05 - How Early Do We Develop IgE Antibodies 59:50 - Colostrum 1:01:15 - T-Cells In The Thymus 1:02:30 - Identifying The 4 Immuno-Types 1:07:20 - Inflammation And CRP 1:09:10 - Conventional & Specialized Lab Tests 1:09:25 - BLISSY: Get Cooling, Comfortable, Sustainable Silk Pillowcases To Revolutionize Your Sleep, Skin, And Hair! Once You Get Silk Pillowcases, You Will Never Look Back! Get Blissy In Tons Of Colors, And Risk-Free For 60 Nights, At Blissy.Com/Melanieavalon, With The Code Melanieavalon For 30% Off! 1:12:55 - How To Truly Boost The Immune System 1:18:00 - Sex And The Immune System 1:20:25 - How To Repair The Immune System And How Long Does It Take

GET TRANSCRIPT AND FULL SHOWNOTES: melanieavalon.com/othership 2:55 - IF Biohackers: Intermittent Fasting + Real Foods + Life: Join Melanie's Facebook Group At Facebook.com/groups/paleoOMAD For A Weekly Episode GIVEAWAY, And To Discuss And Learn About All Things Biohacking! All Conversations Welcome! 3:05 - Follow Melanie On Instagram To See The Latest Moments, Products, And #AllTheThings! @MelanieAvalon 3:30 - AVALONX BERBERINE: This Natural, Potent Anti-Inflammatory Plant Alkaloid Reduces Blood Sugar And Blood Lipids, Aids Weight Loss, Supports A Healthy Body Composition, Stimulates AMPK And Autophagy, Benefits Gut Bacteria And GI Health, And More! AvalonX Supplements Are Free Of Toxic Fillers And Common Allergens (Including Wheat, Rice, Gluten, Dairy, Shellfish, Nuts, Soy, Eggs, And Yeast), Tested To Be Free Of Heavy Metals And Mold, And Triple Tested For Purity And Potency. Get On The Email List To Stay Up To Date With All The Special Offers And News About Melanie's New Supplements At avalonx.us/emaillist! Get 10% Off avalonx.us And mdlogichealth.com With The Code MelanieAvalon! Text AVALONX To 877-861-8318 For A One Time 20% Off Code for avalonx.us 5:15 - FOOD SENSE GUIDE: Get Melanie's App At Melanieavalon.com/foodsenseguide To Tackle Your Food Sensitivities! Food Sense Includes A Searchable Catalogue Of 300+ Foods, Revealing Their Gluten, FODMAP, Lectin, Histamine, Amine, Glutamate, Oxalate, Salicylate, Sulfite, And Thiol Status. Food Sense Also Includes Compound Overviews, Reactions To Look For, Lists Of Foods High And Low In Them, The Ability To Create Your Own Personal Lists, And More! 5:45 - BEAUTYCOUNTER: Non-Toxic Beauty Products Tested For Heavy Metals, Which Support Skin Health And Look Amazing! Shop At beautycounter.com/melanieavalon For Something Magical! For Exclusive Offers And Discounts, And More On The Science Of Skincare, Get On Melanie's Private Beautycounter Email List At Melanieavalon.Com/Cleanbeauty Or Text BEAUTYCOUNTER To 877-861-8318! Find Your Perfect Beautycounter Products With Melanie's Quiz: melanieavalon.com/beautycounterquiz Go To melanieavalon.com/othershipapp For A 2 Week Free Trial! 9:15 - New Fatherhood 11:45 - Othership 12:35 - Ayahuasca Journeys 15:45 - Finding A Reputable Ayahuasca Ceremony Or Center 17:50 - Turning Away From Drugs And Alcohol 21:40 - Working With Crypto 23:45 - Robbie's Wearables 24:45 - Cryotherapy And Ice Baths  27:50 - LMNT: For Fasting Or Low-Carb Diets Electrolytes Are Key For Relieving Hunger, Cramps, Headaches, Tiredness, And Dizziness. With No Sugar, Artificial Ingredients, Coloring, And Only 2 Grams Of Carbs Per Packet, Try LMNT For Complete And Total Hydration. For A Limited Time Go To drinklmnt.com/melanieavalon To Get A Sample Pack With Any Purchase! 31:00 - Creating A Meditation Practice 34:40 - What Is Sauna's Role? Robbie's Sauna Classes 38:15 - The Type Of Saunas In Class 39:45 - Alternating Sauna And Ice Baths 41:20 - Othership Locations 44:45 - The Othership App 49:30 - DRY FARM WINES: Low Sugar, Low Alcohol, Toxin-Free, Mold-Free, Pesticide-Free, Hang-Over Free Natural Wine! Use The Link dryfarmwines.com/melanieavalon To Get A Bottle For A Penny! 51:10 - Using Music To Create Moods In The Mediation Sessions 54:10 - Is There A Learning Curve?  55:50 - Robbie's Habits With The App 59:00 - Altered State Breaths 1:00:55 - Where Can You Do These Sessions? 1:02:40 - Simple Breath Exercises  1:05:40 - Replacing Coffee With Breathwork 1:06:50 - Intermittent Fasting Go To melanieavalon.com/othershipapp For A 2 Week Free Trial! 1:10:40 - How Best To Get Started With Othership 1:14:45 - SUNLIGHTEN: Get Up To $200 Off AND $99 Shipping (Regularly $598) With The Code MelanieAvalon At MelanieAvalon.Com/Sunlighten. Forward Your Proof Of Purchase To Podcast@MelanieAvalon.com, To Receive A Signed Copy Of What When Wine! 1:15:55 - Raising Kids With Biohacking Habits

GET TRANSCRIPT AND FULL SHOWNOTES: melanieavalon.com/othership 2:55 - IF Biohackers: Intermittent Fasting + Real Foods + Life: Join Melanie's Facebook Group At Facebook.com/groups/paleoOMAD For A Weekly Episode GIVEAWAY, And To Discuss And Learn About All Things Biohacking! All Conversations Welcome! 3:05 - Follow Melanie On Instagram To See The Latest Moments, Products, And #AllTheThings! @MelanieAvalon 3:30 - AVALONX BERBERINE: This Natural, Potent Anti-Inflammatory Plant Alkaloid Reduces Blood Sugar And Blood Lipids, Aids Weight Loss, Supports A Healthy Body Composition, Stimulates AMPK And Autophagy, Benefits Gut Bacteria And GI Health, And More! AvalonX Supplements Are Free Of Toxic Fillers And Common Allergens (Including Wheat, Rice, Gluten, Dairy, Shellfish, Nuts, Soy, Eggs, And Yeast), Tested To Be Free Of Heavy Metals And Mold, And Triple Tested For Purity And Potency. Get On The Email List To Stay Up To Date With All The Special Offers And News About Melanie's New Supplements At avalonx.us/emaillist! Get 10% Off avalonx.us And mdlogichealth.com With The Code MelanieAvalon! Text AVALONX To 877-861-8318 For A One Time 20% Off Code for avalonx.us 5:15 - FOOD SENSE GUIDE: Get Melanie's App At Melanieavalon.com/foodsenseguide To Tackle Your Food Sensitivities! Food Sense Includes A Searchable Catalogue Of 300+ Foods, Revealing Their Gluten, FODMAP, Lectin, Histamine, Amine, Glutamate, Oxalate, Salicylate, Sulfite, And Thiol Status. Food Sense Also Includes Compound Overviews, Reactions To Look For, Lists Of Foods High And Low In Them, The Ability To Create Your Own Personal Lists, And More! 5:45 - BEAUTYCOUNTER: Non-Toxic Beauty Products Tested For Heavy Metals, Which Support Skin Health And Look Amazing! Shop At beautycounter.com/melanieavalon For Something Magical! For Exclusive Offers And Discounts, And More On The Science Of Skincare, Get On Melanie's Private Beautycounter Email List At Melanieavalon.Com/Cleanbeauty Or Text BEAUTYCOUNTER To 877-861-8318! Find Your Perfect Beautycounter Products With Melanie's Quiz: melanieavalon.com/beautycounterquiz Go To melanieavalon.com/othershipapp For A 2 Week Free Trial! 9:15 - New Fatherhood 11:45 - Othership 12:35 - Ayahuasca Journeys 15:45 - Finding A Reputable Ayahuasca Ceremony Or Center 17:50 - Turning Away From Drugs And Alcohol 21:40 - Working With Crypto 23:45 - Robbie's Wearables 24:45 - Cryotherapy And Ice Baths  27:50 - LMNT: For Fasting Or Low-Carb Diets Electrolytes Are Key For Relieving Hunger, Cramps, Headaches, Tiredness, And Dizziness. With No Sugar, Artificial Ingredients, Coloring, And Only 2 Grams Of Carbs Per Packet, Try LMNT For Complete And Total Hydration. For A Limited Time Go To drinklmnt.com/melanieavalon To Get A Sample Pack With Any Purchase! 31:00 - Creating A Meditation Practice 34:40 - What Is Sauna's Role? Robbie's Sauna Classes 38:15 - The Type Of Saunas In Class 39:45 - Alternating Sauna And Ice Baths 41:20 - Othership Locations 44:45 - The Othership App 49:30 - DRY FARM WINES: Low Sugar, Low Alcohol, Toxin-Free, Mold-Free, Pesticide-Free, Hang-Over Free Natural Wine! Use The Link dryfarmwines.com/melanieavalon To Get A Bottle For A Penny! 51:10 - Using Music To Create Moods In The Mediation Sessions 54:10 - Is There A Learning Curve?  55:50 - Robbie's Habits With The App 59:00 - Altered State Breaths 1:00:55 - Where Can You Do These Sessions? 1:02:40 - Simple Breath Exercises  1:05:40 - Replacing Coffee With Breathwork 1:06:50 - Intermittent Fasting Go To melanieavalon.com/othershipapp For A 2 Week Free Trial! 1:10:40 - How Best To Get Started With Othership 1:14:45 - SUNLIGHTEN: Get Up To $200 Off AND $99 Shipping (Regularly $598) With The Code MelanieAvalon At MelanieAvalon.Com/Sunlighten. Forward Your Proof Of Purchase To Podcast@MelanieAvalon.com, To Receive A Signed Copy Of What When Wine! 1:15:55 - Raising Kids With Biohacking Habits

GET TRANSCRIPT AND FULL SHOWNOTES: melanieavalon.com/2022part2 2:05 - IF Biohackers: Intermittent Fasting + Real Foods + Life: Join Melanie's Facebook Group At Facebook.com/groups/paleoOMAD For A Weekly Episode GIVEAWAY, And To Discuss And Learn About All Things Biohacking! All Conversations Welcome! 2:20 - Follow Melanie On Instagram To See The Latest Moments, Products, And #AllTheThings! @MelanieAvalon 2:30 - AVALONX BERBERINE: This Natural, Potent Anti-Inflammatory Plant Alkaloid Reduces Blood Sugar And Blood Lipids, Aids Weight Loss, Supports A Healthy Body Composition, Stimulates AMPK And Autophagy, Benefits Gut Bacteria And GI Health, And More! AvalonX Supplements Are Free Of Toxic Fillers And Common Allergens (Including Wheat, Rice, Gluten, Dairy, Shellfish, Nuts, Soy, Eggs, And Yeast), Tested To Be Free Of Heavy Metals And Mold, And Triple Tested For Purity And Potency. Get On The Email List To Stay Up To Date With All The Special Offers And News About Melanie's New Supplements At avalonx.us/emaillist! Get 10% Off avalonx.us And mdlogichealth.com With The Code MelanieAvalon! Text AVALONX To 877-861-8318 For A One Time 20% Off Code For avalonx.us 5:10 - FOOD SENSE GUIDE: Get Melanie's App At Melanieavalon.com/foodsenseguide To Tackle Your Food Sensitivities! Food Sense Includes A Searchable Catalogue Of 300+ Foods, Revealing Their Gluten, FODMAP, Lectin, Histamine, Amine, Glutamate, Oxalate, Salicylate, Sulfite, And Thiol Status. Food Sense Also Includes Compound Overviews, Reactions To Look For, Lists Of Foods High And Low In Them, The Ability To Create Your Own Personal Lists, And More! 5:45 - BEAUTYCOUNTER: Non-Toxic Beauty Products Tested For Heavy Metals, Which Support Skin Health And Look Amazing! Shop At beautycounter.com/melanieavalon For Something Magical! For Exclusive Offers And Discounts, And More On The Science Of Skincare, Get On Melanie's Private Beautycounter Email List At Melanieavalon.Com/Cleanbeauty Or Text BEAUTYCOUNTER To 877-861-8318! Find Your Perfect Beautycounter Products With Melanie's Quiz: melanieavalon.com/beautycounterquiz 8:05 - Farmer Lee Jones: Eating Your Vegetable Tops  12:25 - Mark Schatzker: Does More Vitamin Fortification Equal More Obesity? 17:35 - Dr. Sheryl Ross: Freezing Your Eggs 22:00 - BONCHARGE: Blue-light Blocking Glasses For Sleep, Stress, And Health! Go To boncharge.com And Use The Code melanieavalon For 15% Off! 24:30 - A.J. Jacobs: Unifying People Through Puzzles 28:00 - Max Lugavere: Veganism and Brain Health 33:05 - Dr. Steven Gundry: Mitochondrial Uncoupling  38:25 - Dr. Morgan Levine: Measuring Biological Age 46:15 - BLISSY: Get Cooling, Comfortable, Sustainable Silk Pillowcases To Revolutionize Your Sleep, Skin, And Hair! Once You Get Silk Pillowcases, You Will Never Look Back! Get Blissy In Tons Of Colors, And Risk-Free For 60 Nights, At Blissy.Com/avalon, With The Code avalon For 30% Off! 49:45 - Ari Whitten: Chronic Fatigue 55:00 - John Gray (Part 1): Prioritizing Your Partner 59:45 - Dr. David Perlmutte: Gender And Uric Acid 1:07:50 - Simon Hill: Lectins and other Antinutrients 1:13:35 - Mark Sisson: The Concept Of Play In Our History

GET TRANSCRIPT AND FULL SHOWNOTES: melanieavalon.com/2022part1 2:10 - IF Biohackers: Intermittent Fasting + Real Foods + Life: Join Melanie's Facebook Group For A Weekly Episode GIVEAWAY, And To Discuss And Learn About All Things Biohacking! All Conversations Welcome! 2:15 - Follow Melanie On Instagram To See The Latest Moments, Products, And #AllTheThings! @MelanieAvalon 2:25 - AVALONX BERBERINE: This Natural, Potent Anti-Inflammatory Plant Alkaloid Reduces Blood Sugar And Blood Lipids, Aids Weight Loss, Supports A Healthy Body Composition, Stimulates AMPK And Autophagy, Benefits Gut Bacteria And GI Health, And More! Stock Up During The Launch Special From 12/16/22-12/31/22, Get 15% Off Of 1 Bottle With Code MABERB15, And 25% Off 2 Or More Bottles With The Code MABERB25!   AvalonX Supplements Are Free Of Toxic Fillers And Common Allergens (Including Wheat, Rice, Gluten, Dairy, Shellfish, Nuts, Soy, Eggs, And Yeast), Tested To Be Free Of Heavy Metals And Mold, And Triple Tested For Purity And Potency. Get On The Email List To Stay Up To Date With All The Special Offers And News About Melanie's New Supplements At avalonx.us/emaillist! Site Wide Get 10% Off avalonx.us And mdlogichealth.com With The Code MelanieAvalon Text AVALONX To 877-861-8318 For A One Time 20% Off Code for avalonx.us 6:40 - FOOD SENSE GUIDE: Get Melanie's App At Melanieavalon.com/foodsenseguide To Tackle Your Food Sensitivities! Food Sense Includes A Searchable Catalogue Of 300+ Foods, Revealing Their Gluten, FODMAP, Lectin, Histamine, Amine, Glutamate, Oxalate, Salicylate, Sulfite, And Thiol Status. Food Sense Also Includes Compound Overviews, Reactions To Look For, Lists Of Foods High And Low In Them, The Ability To Create Your Own Personal Lists, And More! 7:10 - BEAUTYCOUNTER: Non-Toxic Beauty Products Tested For Heavy Metals, Which Support Skin Health And Look Amazing! Shop At beautycounter.com/melanieavalon For Something Magical! For Exclusive Offers And Discounts, And More On The Science Of Skincare, Get On Melanie's Private Beautycounter Email List At Melanieavalon.Com/Cleanbeauty Or Text BEAUTYCOUNTER To 877-861-8318! Find Your Perfect Beautycounter Products With Melanie's Quiz: melanieavalon.com/beautycounterquiz 9:45 - Dr. Karen Becker: Living Food Diet For Your Pets 15:15 - Dr. Rick Johnson: Fructose Tricks The Body And Making Fat From Fructose And Glucose 22:05 - Dr. Gabrielle Lyon: What Determines Our Protein Needs 27:50 - LOMI: Turn Your Kitchen Scraps Into Dirt, To Reduce Waste, Add Carbon Back To The Soil, And Support Sustainability! Get $50 Off Lomi At Lomi.Com/Melanieavalon With The Code MELANIEAVALON! 31:20 - Dr. Will Bulsiewcz: Gluten Restriction And The Importance Of Whole Grains 38:10 - Dr. Laurie Mintz: The G Spot And Media Hype 43:50 - Bill Schindler: How Do We Eat Grains? 49:30 - Dom D'Agostino: Why We Enter Ketosis 54:20 - BLISSY: Get Cooling, Comfortable, Sustainable Silk Pillowcases To Revolutionize Your -Sleep, Skin, And Hair! Once You Get Silk Pillowcases, You Will Never Look Back! Get Blissy In Tons Of Colors, And Risk-Free For 60 Nights, At Blissy.Com/Melanieavalon, With The Code Melanieavalon For 30% Off! 57:45 - Chris Masterjohn: Development Of RDAs For Vitamins 1:07:10 - Anna Lembke: Habit Vs Addiction And Should We Chose Abstinence Or Moderation? 1:13:20 - Megan Ramos - Thin On The Outside, Fat On The Inside And Body Composition

GET TRANSCRIPT AND FULL SHOWNOTES: melanieavalon.com/puzzles 2:00 - IF Biohackers: Intermittent Fasting + Real Foods + Life: Join Melanie's Facebook Group At Facebook.com/groups/paleoOMAD For A Weekly Episode GIVEAWAY, And To Discuss And Learn About All Things Biohacking! All Conversations Welcome! 2:10 - Follow Melanie On Instagram To See The Latest Moments, Products, And #AllTheThings! @MelanieAvalon 2:20 - AVALONX BERBERINE: This Natural, Potent Anti-Inflammatory Plant Alkaloid Reduces Blood Sugar And Blood Lipids, Aids Weight Loss, Supports A Healthy Body Composition, Stimulates AMPK And Autophagy, Benefits Gut Bacteria And GI Health, And More! Stock Up During The Launch Special From 12/16/22-12/31/22, Get 15% Off Of 1 Bottle With Code MABERB15, And 25% Off 2 Or More Bottles With The Code MABERB25!   AvalonX Supplements Are Free Of Toxic Fillers And Common Allergens (Including Wheat, Rice, Gluten, Dairy, Shellfish, Nuts, Soy, Eggs, And Yeast), Tested To Be Free Of Heavy Metals And Mold, And Triple Tested For Purity And Potency. Get On The Email List To Stay Up To Date With All The Special Offers And News About Melanie's New Supplements At avalonx.us/emaillist! Site Wide Get 10% Off avalonx.us And mdlogichealth.com With The Code MelanieAvalon Text AVALONX To 877-861-8318 For A One Time 20% Off Code for avalonx.us 5:20 - FOOD SENSE GUIDE: Get Melanie's App At Melanieavalon.com/foodsenseguide To Tackle Your Food Sensitivities! Food Sense Includes A Searchable Catalogue Of 300+ Foods, Revealing Their Gluten, FODMAP, Lectin, Histamine, Amine, Glutamate, Oxalate, Salicylate, Sulfite, And Thiol Status. Food Sense Also Includes Compound Overviews, Reactions To Look For, Lists Of Foods High And Low In Them, The Ability To Create Your Own Personal Lists, And More! 6:00 - BEAUTYCOUNTER: Non-Toxic Beauty Products Tested For Heavy Metals, Which Support Skin Health And Look Amazing! Shop At beautycounter.com/melanieavalon For Something Magical! For Exclusive Offers And Discounts, And More On The Science Of Skincare, Get On Melanie's Private Beautycounter Email List At Melanieavalon.Com/Cleanbeauty Or Text BEAUTYCOUNTER To 877-861-8318! Find Your Perfect Beautycounter Products With Melanie's Quiz: melanieavalon.com/beautycounterquiz 10:30 - AJ As A Kid 12:40 - AJ's Curiosities 16:10 - Sleep Exercises 18:20 - Sincerity In Gratitude 22:30 - Changing "Thank You" To "I Am Grateful For..." 24:30 - Writing The Puzzler 27:30 - Logic Puzzles 29:30 - The Rubix Cube 31:00 - Team USA Jigsaw Puzzle Championship 38:35 - Masochism In Puzzles  39:55 - FEALS: Feals Makes CBD Oil Which Satisfies ALL Of Melanie's Stringent Criteria - It's Premium, Full Spectrum, Organic, Tested, Pure CBD In MCT Oil! It's Delivered Directly To Your Doorstep. CBD Supports The Body's Natural Cannabinoid System, And Can Address An Array Of Issues, From Sleep To Stress To Chronic Pain, And More! Go To feals.com/melanieavalon To Become A Member And Get 40% Off Your First 3 Months, With Free Shipping! 42:40 - Jigsaw Puzzles Vs Life Puzzles 44:40 - Crosswords 50:50 - Brain Benefits Of Puzzles And Games 54:10 - The Sleeping Beauty Puzzle/The Monty Hall Puzzle  1:00:25 - Solving Counterintuitive Puzzles 1:06:15 - LMNT: For Fasting Or Low-Carb Diets Electrolytes Are Key For Relieving Hunger, Cramps, Headaches, Tiredness, And Dizziness. With No Sugar, Artificial Ingredients, Coloring, And Only 2 Grams Of Carbs Per Packet, Try LMNT For Complete And Total Hydration. For A Limited Time Go To drinklmnt.com/melanieavalon To Get A Sample Pack With Any Purchase, And Try The Chocolate Medley While Supplies Last! 1:09:45 - Melanie's Life Puzzle 1:12:40 - Sneaking Into MENSA 1:14:50 - The MENSA Meetings 1:19:40 - Escape Rooms 1:21:45 - Unifying People Through Puzzles

GET TRANSCRIPT AND FULL SHOWNOTES: melanieavalon.com/rezoom 2:15 - IF Biohackers: Intermittent Fasting + Real Foods + Life: Join Melanie's Facebook Group At Facebook.com/groups/paleoOMAD For A Weekly Episode GIVEAWAY, And To Discuss And Learn About All Things Biohacking! All Conversations Welcome! 2:25 - Follow Melanie On Instagram To See The Latest Moments, Products, And #AllTheThings! @MelanieAvalon 5:00 - AVALONX BERBERINE: This Natural, Potent Anti-Inflammatory Plant Alkaloid Reduces Blood Sugar And Blood Lipids, Aids Weight Loss, Supports A Healthy Body Composition, Stimulates AMPK And Autophagy, Benefits Gut Bacteria And GI Health, And More! Stock Up During The Launch Special From 12/16/22-12/31/22!  AvalonX Supplements Are Free Of Toxic Fillers And Common Allergens (Including Wheat, Rice, Gluten, Dairy, Shellfish, Nuts, Soy, Eggs, And Yeast), Tested To Be Free Of Heavy Metals And Mold, And Triple Tested For Purity And Potency. Get On The Email List To Stay Up To Date With All The Special Offers And News About Melanie's New Supplements At avalonx.us/emaillist! Get 10% Off avalonx.us And mdlogichealth.com With The Code MelanieAvalon Text AVALONX To 877-861-8318 For A One Time 20% Off Code for avalonx.us 6:00 - FOOD SENSE GUIDE: Get Melanie's App At Melanieavalon.com/foodsenseguide To Tackle Your Food Sensitivities! Food Sense Includes A Searchable Catalogue Of 300+ Foods, Revealing Their Gluten, FODMAP, Lectin, Histamine, Amine, Glutamate, Oxalate, Salicylate, Sulfite, And Thiol Status. Food Sense Also Includes Compound Overviews, Reactions To Look For, Lists Of Foods High And Low In Them, The Ability To Create Your Own Personal Lists, And More! 7:20 - BEAUTYCOUNTER: Non-Toxic Beauty Products Tested For Heavy Metals, Which Support Skin Health And Look Amazing! Shop At beautycounter.com/melanieavalon For Something Magical! For Exclusive Offers And Discounts, And More On The Science Of Skincare, Get On Melanie's Private Beautycounter Email List At Melanieavalon.Com/Cleanbeauty Or Text BEAUTYCOUNTER To 877-861-8318! Find Your Perfect Beautycounter Products With Melanie's Quiz: melanieavalon.com/beautycounterquiz 13:00 - Susan's Personal Story 20:30 - From One Addiction To Another 23:00 - Moment Of Insight 26:50 - Defining Addiction 28:30 - Why Society Doesn't Think Food Can Be Addicting? 37:05 - BEAUTY AND THE BROTH: Support Your Health With Delicious USDA Organic Beauty & The Broth Bone Broth! It's Shelf Stable With No Preservatives, And No Salt Added. Choose Grass Fed, Grass Finished Beef, Or Free Range, Anti-Biotic And Hormone Free Range, Antibiotic And Hormone-Free Chicken, Or Their NEW Organic Vegan Mushroom Broth Concentrate Shipped Straight To Your Door! The Concentrated Packets Are 8x Stronger Than Any Cup Of Broth: Simply Reconstitute With 8 Ounces Of Hot Water. They're Convenient To Take Anywhere On The Go, Especially Travel! Go To melanieavalon.com/broth To Get 15% Off Any Order With The Code MelanieAvalon! 41:00 - What Would Treatment Look Like? 44:04 - Intuitive Eating 46:00 - Dopamine Levels In People Who Dont Become Addicted 47:40 - Brightline Eating Approach And Remission 51:20 - Raising Kids And Their Food Habits 54:00 - The Division Of Responsibility - Ellyn Satter 55:00 - The Genetics Of Addiction 57:00 - Exercise Addiction 57:45 - Go Vs. No Go Pathway 1:03:00 - LOMI: Turn Your Kitchen Scraps Into Dirt, To Reduce Waste, Add Carbon Back To The Soil, And Support Sustainability! Get $50 Off Lomi At Lomi.Com/Melanieavalon With The Code MELANIEAVALON! 1:07:00 - The Context Around Consuming Addicting Foods 1:10:20 - How Do You Refrain Relapse? 1:19:20 - Implementing Parts Work 1:20:30 - Rezoom Reframe 1:22:30 - How Should You Define Success? 1:27:15 - Using Fasting As A Boundary 1:32:00 - The Catalyst To Writing Rezoom

Visit IFpodcast.com/episode295 For FULL Shownotes, And IFPodcast.com/StuffWeLike For All The Stuff We Like! 1:10 - BUTCHERBOX: For A Limited Time Go To butcherbox.com/ifpodcast And Get Free Ground Beef For LIFE Plus $20 Off Your First Box!! 4:10 - BEAUTYCOUNTER: Keep Your Fast Clean Inside And Out With Safe Skincare! Shop With Us At melanieavalon.com/beautycounter Or beautycounter.com/cynthiathurlow And Use The Code CLEANFORALL20 For 20% Off PLUS Something Magical Might Happen After Your First Order! Find Your Perfect Beautycounter Products With Melanie's Quiz: Melanieavalon.Com/Beautycounterquiz Go To cynthiathurlow.com/creatine and use code CYNTHIA for 10% off! 21:40 - BEAUTY AND THE BROTH: Go To melanieavalon.com/broth To Get 15% Off Any Order With The Code MelanieAvalon! 25:40 - Listener Q&A: Heather - IF 32:10 - Listener Q&A: Robyn - Chronic Pain Flair Go To eatpluck.com An Use The Code CYNTHIA15 For 15% Off! FOOD SENSE GUIDE: Get Melanie's App At Melanieavalon.com/foodsenseguide To Tackle Your Food Sensitivities! Food Sense Includes A Searchable Catalogue Of 300+ Foods, Revealing Their Gluten, FODMAP, Lectin, Histamine, Amine, Glutamate, Oxalate, Salicylate, Sulfite, And Thiol Status. Food Sense Also Includes Compound Overviews, Reactions To Look For, Lists Of Foods High And Low In Them, The Ability To Create Your Own Personal Lists, And More! Go To safecatch.com And Use The Coupon Code For MELANIEAVALON For 20% Off! 51:40 - FEALS: Go To feals.com/ifpodcast To Become A Member And Get 50% Off Your First Order, With Free Shipping! 54:30 - Listener Q&A: Therese - Repetitive Routines Or Mix It Up? 55:10 - Listener Q&A: James - Constantly Changing Fasting Windows Our content does not constitute an attempt to practice medicine, and does not establish a doctor-patient relationship. Please consult a qualified health care provider for medical advice and answers to personal health questions.

GET TRANSCRIPT AND FULL SHOWNOTES: melanieavalon.com/donttrustyourgut 2:00 - IF Biohackers: Intermittent Fasting + Real Foods + Life: Join Melanie's Facebook Group At Facebook.com/groups/paleoOMAD For A Weekly Episode GIVEAWAY, And To Discuss And Learn About All Things Biohacking! All Conversations Welcome! 2;15 - Follow Melanie On Instagram To See The Latest Moments, Products, And #AllTheThings! @MelanieAvalon 2:50 - AVALONX BERBERINE: This Natural, Potent Anti-Inflammatory Plant Alkaloid Reduces Blood Sugar And Blood Lipids, Aids Weight Loss, Supports A Healthy Body Composition, Stimulates AMPK And Autophagy, Benefits Gut Bacteria And GI Health, And More! Stock Up During The Launch Special From 12/16/22-12/31/22!  AvalonX Supplements Are Free Of Toxic Fillers And Common Allergens (Including Wheat, Rice, Gluten, Dairy, Shellfish, Nuts, Soy, Eggs, And Yeast), Tested To Be Free Of Heavy Metals And Mold, And Triple Tested For Purity And Potency. Get On The Email List To Stay Up To Date With All The Special Offers And News About Melanie's New Supplements At avalonx.us/emaillist! Get 10% Off avalonx.us And mdlogichealth.com With The Code MelanieAvalon Text AVALONX To 877-861-8318 For A One Time 20% Off Code for avalonx.us 5:45 - FOOD SENSE GUIDE: Get Melanie's App At Melanieavalon.com/foodsenseguide To Tackle Your Food Sensitivities! Food Sense Includes A Searchable Catalogue Of 300+ Foods, Revealing Their Gluten, FODMAP, Lectin, Histamine, Amine, Glutamate, Oxalate, Salicylate, Sulfite, And Thiol Status. Food Sense Also Includes Compound Overviews, Reactions To Look For, Lists Of Foods High And Low In Them, The Ability To Create Your Own Personal Lists, And More! 6:15 - BEAUTYCOUNTER: Non-Toxic Beauty Products Tested For Heavy Metals, Which Support Skin Health And Look Amazing! Shop At beautycounter.com/melanieavalon For Something Magical! For Exclusive Offers And Discounts, And More On The Science Of Skincare, Get On Melanie's Private Beautycounter Email List At Melanieavalon.Com/Cleanbeauty Or Text BEAUTYCOUNTER To 877-861-8318! Find Your Perfect Beautycounter Products With Melanie's Quiz: melanieavalon.com/beautycounterquiz 10:05 - Seth's Backstory 11:30 - What Can Data Predict? And Why? 14:40 - Emotional Red Flags 15:45 - Feelings On The First Date 16:15 - Data Gathering For Relationships 17:30 - The Root Of Attraction 23:00 - Age Gaps In Dating 25:50 - Attractiveness Of Careers 26:30 - Racial Disparity In Dating 29:00 - Predictors Of Happiness 30:15 - Cliched Pieces Of Wisdom 31:50 - LMNT: For Fasting Or Low-Carb Diets Electrolytes Are Key For Relieving Hunger, Cramps, Headaches, Tiredness, And Dizziness. With No Sugar, Artificial Ingredients, Coloring, And Only 2 Grams Of Carbs Per Packet, Try LMNT For Complete And Total Hydration. For A Limited Time Go To drinklmnt.com/melanieavalon To Get A Sample Pack With Any Purchase! 35:30 - Dietary Wars 38:30 - Physical Appearance And Success 42:10 - Implementing Changes Based On Data 48:00 - Sports Genes 51:00 - Having Enough Data Points 52:20 - How Having Passion Predicts Success 53:55 - LOMI: Turn Your Kitchen Scraps Into Dirt, To Reduce Waste, Add Carbon Back To The Soil, And Support Sustainability! Get $50 Off Lomi At Lomi.Com/Melanieavalon With The Code MELANIEAVALON! 57:30 - Data On Parenting 1:01:30 - Parental Decision Making 1:05:00 - Gene Editing 1:06:25 - The Mappiness Project 1:08:00 - What Makes Us Happy? 1:12:25 - Alcohol & Happiness 1:14:00 - The Day After Drinking 1:16:45 - Blue Zone Lies 1:20:20 - Success In Business 1:25:50 - Applying The Data Personally

GET TRANSCRIPT AND FULL SHOWNOTES: melanieavalon.com/regenerativepastures 2:35 - IF Biohackers: Intermittent Fasting + Real Foods + Life: Join Melanie's Facebook Group At Facebook.com/groups/paleoOMAD For A Weekly Episode GIVEAWAY, And To Discuss And Learn About All Things Biohacking! All Conversations Welcome! 2:50 - Follow Melanie On Instagram To See The Latest Moments, Products, And #AllTheThings! @MelanieAvalon 3:35 - AVALONX BERBERINE: This Natural, Potent Anti-Inflammatory Plant Alkaloid Reduces Blood Sugar And Blood Lipids, Aids Weight Loss, Supports A Healthy Body Composition, Stimulates AMPK And Autophagy, Benefits Gut Bacteria And GI Health, And More! Stock Up During The Launch Special From 12/16/22-12/31/22!  AvalonX Supplements Are Free Of Toxic Fillers And Common Allergens (Including Wheat, Rice, Gluten, Dairy, Shellfish, Nuts, Soy, Eggs, And Yeast), Tested To Be Free Of Heavy Metals And Mold, And Triple Tested For Purity And Potency. Get On The Email List To Stay Up To Date With All The Special Offers And News About Melanie's New Supplements At avalonx.us/emaillist! Thru Cyber Monday Get 15% Off $50 Or More And 20% Off $120 Or More At avalonx.us And mdlogichealth.com! Text AVALONX To 877-861-8318 For A One Time 20% Off Code for avalonx.us 7:30 - FOOD SENSE GUIDE: Get Melanie's App At Melanieavalon.com/foodsenseguide To Tackle Your Food Sensitivities! Food Sense Includes A Searchable Catalogue Of 300+ Foods, Revealing Their Gluten, FODMAP, Lectin, Histamine, Amine, Glutamate, Oxalate, Salicylate, Sulfite, And Thiol Status. Food Sense Also Includes Compound Overviews, Reactions To Look For, Lists Of Foods High And Low In Them, The Ability To Create Your Own Personal Lists, And More! 8:00 - BEAUTYCOUNTER: Non-Toxic Beauty Products Tested For Heavy Metals, Which Support Skin Health And Look Amazing! Shop At beautycounter.com/melanieavalon For Something Magical! For Exclusive Offers And Discounts, And More On The Science Of Skincare, Get On Melanie's Private Beautycounter Email List At Melanieavalon.Com/Cleanbeauty Or Text BEAUTYCOUNTER To 877-861-8318! Find Your Perfect Beautycounter Products With Melanie's Quiz: melanieavalon.com/beautycounterquiz 12:30 - Janna And Evan's Beginnings 16:45 - Janna's Cancer Diagnosis 17:55 - Are Modern Agricultural Processes Necessary? 20:45 - What Is Regenerative Agriculture? 25:45 - Do We Have Enough Space To Pasture Enough Animals? 28:15 - What Is AUM Based On? 30:50 - The State Of Our Topsoil 32:30 - Can We Restore The Topsoil With Any Technology? 34:00 - What About Greenhouses Or Reintroducing Nutrients To The Soil? 35:15 - Food Waste 36:20 - FEALS: Feals Makes CBD Oil Which Satisfies ALL Of Melanie's Stringent Criteria - It's Premium, Full Spectrum, Organic, Tested, Pure CBD In MCT Oil! It's Delivered Directly To Your Doorstep. CBD Supports The Body's Natural Cannabinoid System, And Can Address An Array Of Issues, From Sleep To Stress To Chronic Pain, And More! Go To feals.com/melanieavalon To Become A Member And Get 40% Off Your First 3 Months, With Free Shipping! 39:00 - Planning Food Systems On Another Planet 42:00 - The Morality Of Eating Living Creatures 45:35 - The Backlash On Social Media 48:15 - Is It Possible To Get Enough Protein As A Vegan? 50:50 - Nutritional Profile Of Feed Lot Animals Vs Grass Fed 52:30 - Omega-6 To Omega-3 Ratios In Meat 57:10 - Fish And Toxins 58:35 - Detoxing Mercury 1:01:05 - Cryotherapy And Ice Baths 1:01:04 - Toxins In Conventionally Raised Livestock 1:07:30 - Methods To Reducing Stress Of The Animals 1:12:00 - Do Livestock Have Better Lives Then If They Were Wild? 1:15:25 - What Happens During Processing? 1:16:35 - The Natural Circle Of Life 1:19:30 - Food Labeling 1:22:45 - The Role Of Large Industry In Agriculture 1:25:20 - Shopping Local 1:26:30 - Agricultural Subsidies 1:28:00 - BLISSY: Get Cooling, Comfortable, Sustainable Silk Pillowcases To Revolutionize Your Sleep, Skin, And Hair! Once You Get Silk Pillowcases, You Will Never Look Back! Get Blissy In Tons Of Colors, And Risk-Free For 60 Nights, At Blissy.Com/Melanieavalon, With The Code Melanieavalon For 30% Off! 1:31:30 - The Inedible Offal 1:33:15 - The Carbon Problem And Greenhouse Gases 1:37:30 - Reversing Climate Change 1:39:30 - Impossible Meat 1:41:00 - Evan And Janna's Businesses 1:44:15 - The Mental Health And Wellness Of The Ranchers 1:46:40 - What Evan And Janna's Cows Eat 1:47:15 - Wagyu Beef 1:48:45 - Ground Beef 1:50:15 - Beef Heart 1:50:30 - Organ Jerky 1:53:10 - Oxtail 1:55:30 - Why Don't We Crave Organ Meats? Go To regenerativefarms.com To Get 40% Off Your First Box And Ground Beef For Life With The Coupon Code MELANIEAVALON!

GET TRANSCRIPT AND FULL SHOWNOTES: melanieavalon.com/quantumtech Go To melanieavalon.com/leela To Get 10% Off With Coupon Code MELANIE10! 2:40 - IF Biohackers: Intermittent Fasting + Real Foods + Life: Join Melanie's Facebook Group At Facebook.com/groups/paleoOMAD For A Weekly Episode GIVEAWAY, And To Discuss And Learn About All Things Biohacking! All Conversations Welcome! 2:50 - Follow Melanie On Instagram To See The Latest Moments, Products, And #AllTheThings! @MelanieAvalon 3:15 - AVALONX BERBERINE: This Natural, Potent Anti-Inflammatory Plant Alkaloid Reduces Blood Sugar And Blood Lipids, Aids Weight Loss, Supports A Healthy Body Composition, Stimulates AMPK And Autophagy, Benefits Gut Bacteria And GI Health, And More! Stock Up During The Launch Special From 12/16/22-12/31/22!  AvalonX Supplements Are Free Of Toxic Fillers And Common Allergens (Including Wheat, Rice, Gluten, Dairy, Shellfish, Nuts, Soy, Eggs, And Yeast), Tested To Be Free Of Heavy Metals And Mold, And Triple Tested For Purity And Potency. Get On The Email List To Stay Up To Date With All The Special Offers And News About Melanie's New Supplements At avalonx.us/emaillist! Thru Cyber Monday Get 15% Off $50 Or More And 20% Off $120 Or More At avalonx.us And mdlogichealth.com! Text AVALONX To 877-861-8318 For A One Time 20% Off Code for avalonx.us 7:45 - FOOD SENSE GUIDE: Get Melanie's App At Melanieavalon.com/foodsenseguide To Tackle Your Food Sensitivities! Food Sense Includes A Searchable Catalogue Of 300+ Foods, Revealing Their Gluten, FODMAP, Lectin, Histamine, Amine, Glutamate, Oxalate, Salicylate, Sulfite, And Thiol Status. Food Sense Also Includes Compound Overviews, Reactions To Look For, Lists Of Foods High And Low In Them, The Ability To Create Your Own Personal Lists, And More! 8:20 - BEAUTYCOUNTER: Non-Toxic Beauty Products Tested For Heavy Metals, Which Support Skin Health And Look Amazing! Shop At beautycounter.com/melanieavalon For Something Magical! For Exclusive Offers And Discounts, And More On The Science Of Skincare, Get On Melanie's Private Beautycounter Email List At Melanieavalon.Com/Cleanbeauty Or Text BEAUTYCOUNTER To 877-861-8318! Find Your Perfect Beautycounter Products With Melanie's Quiz: melanieavalon.com/beautycounterquiz 14:50 - Philipp's Backstory 20:10 - How Much Of Energy Healing Is Real? 24:00 - LMNT: For Fasting Or Low-Carb Diets Electrolytes Are Key For Relieving Hunger, Cramps, Headaches, Tiredness, And Dizziness. With No Sugar, Artificial Ingredients, Coloring, And Only 2 Grams Of Carbs Per Packet, Try LMNT For Complete And Total Hydration. For A Limited Time Go To drinklmnt.com/melanieavalon To Get A Sample Pack With Any Purchase, And Try The Chocolate Medley While Supplies Last! 27:40 - EMF Blocking Products 29:10 - Defining Quantum Fields 33:25 - Radio Waves 34:55 - How The Bloc Work 38:40 - How Do You Charge? 40:00 - Can The Bloc Be Damaged? 41:10 - How Long Do You Need To Charge Other Items? 44:30 - Dark Field Microscopy 49:55 - The Set Up Of The Studies 53:45 - The Patients In The Studies 55:10 - Cesium-137 57:40 - Food Sensitivities 1:02:00 - LOMI: Turn Your Kitchen Scraps Into Dirt, To Reduce Waste, Add Carbon Back To The Soil, And Support Sustainability! Get $50 Off Lomi At lomi.com/melanieavalon With The Code MELANIEAVALON! 1:06:10 - How Do We Know It's Not Placebo Effect? 1:09:05 - Can You Feel The Energy? 1:13:10 - Autism Study 1:15:20 - Leela Quantum H.E.A.L. Energy Capsule 1:18:10 - Toxic Information; The BESA Method 1:26:40 - Bringing These Products To Market 1:27:55 - Leela Quantum Energy Frequency Card 1:30:10 - How Philipp Uses The Technology Every Day

GET TRANSCRIPT AND FULL SHOWNOTES: melanieavalon.com/wendymyers 2:15 - IF Biohackers: Intermittent Fasting + Real Foods + Life: Join Melanie's Facebook Group At Facebook.com/groups/paleoOMAD For A Weekly Episode GIVEAWAY, And To Discuss And Learn About All Things Biohacking! All Conversations Welcome! 2:25 - Follow Melanie On Instagram To See The Latest Moments, Products, And #AllTheThings! 2:50 - AVALONX BERBERINE: This Natural, Potent Anti-Inflammatory Plant Alkaloid Reduces Blood Sugar And Blood Lipids, Aids Weight Loss, Supports A Healthy Body Composition, Stimulates AMPK And Autophagy, Benefits Gut Bacteria And GI Health, And More! Stock Up During The Launch Special From 12/16/22-12/31/22! AvalonX Supplements Are Free Of Toxic Fillers And Common Allergens (Including Wheat, Rice, Gluten, Dairy, Shellfish, Nuts, Soy, Eggs, And Yeast), Tested To Be Free Of Heavy Metals And Mold, And Triple Tested For Purity And Potency. Get On The Email List To Stay Up To Date With All The Special Offers And News About Melanie's New Supplements At avalonx.us/emaillist! Use The Code Melanieavalon For 10% Off AvalonX.Us And MDlogichealth.Com Text AVALONX To 877-861-8318 For A One Time 20% Off Code for avalonx.us 5:50 - FOOD SENSE GUIDE: Get Melanie's App At Melanieavalon.com/foodsenseguide To Tackle Your Food Sensitivities! Food Sense Includes A Searchable Catalogue Of 300+ Foods, Revealing Their Gluten, FODMAP, Lectin, Histamine, Amine, Glutamate, Oxalate, Salicylate, Sulfite, And Thiol Status. Food Sense Also Includes Compound Overviews, Reactions To Look For, Lists Of Foods High And Low In Them, The Ability To Create Your Own Personal Lists, And More! 6:30 - BEAUTYCOUNTER: Non-Toxic Beauty Products Tested For Heavy Metals, Which Support Skin Health And Look Amazing! Shop At beautycounter.com/melanieavalon For Something Magical! For Exclusive Offers And Discounts, And More On The Science Of Skincare, Get On Melanie's Private Beautycounter Email List At Melanieavalon.Com/Cleanbeauty Or Text BEAUTYCOUNTER To 877-861-8318! Find Your Perfect Beautycounter Products With Melanie's Quiz: melanieavalon.com/beautycounterquiz Join Melanie's Facebook Group Clean Beauty And Safe Skincare With Melanie Avalon To Discuss And Learn About All The Things Clean Beauty, Beautycounter And Safe Skincare! 11:00 - Wendy's Personal Story 15:00 - Wendy's Heavy Metal Exposure 16:15 - Low Vs. High Mercury Fish 16:35 - Different Styles Of Toxin Testing 19:10 - How Much Detox Is Enough? 21:50 - Heavy Metals Effect Inside The Body 27:05 - Processed Foods 29:45 - BLISSY: Get Cooling, Comfortable, Sustainable Silk Pillowcases To Revolutionize Your Sleep, Skin, And Hair! Once You Get Silk Pillowcases, You Will Never Look Back! Get Blissy In Tons Of Colors, And Risk-Free For 60 Nights, At Blissy.Com/Melanieavalon, With The Code Melanieavalon For 30% Off! ​33:25 - Carcinogen Classification 33:35 - Half Life Of Heavy Metals 36:40 - Herbs & Spices As Detox Agents 38:35 - Air Filtration 41:00 - How To Start A Detox Protocol 44:00 - Is A General Detox Enough? Do You Have To Detox Specific Metals? 46:50 - Hair Testing 49:00 - Coffee Enemas 53:20 - SUNLIGHTEN: Get Up To $200 Off AND $99 Shipping (Regularly $598) With The Code MelanieAvalon At MelanieAvalon.Com/Sunlighten. Forward Your Proof Of Purchase To Podcast@MelanieAvalon.com, To Receive A Signed Copy Of What When Wine! ​55:45 - Modified Citrus Pectin 56:50 - Chlorella 59:00 - Forms Of Chlorella & Spirulina 59:45 - Redistribution During Detox 1:02:25 - Ness Bioenergetic Health Practitioners 1:05:20 - Getting A Ness Scan 1:05:45 - Rife Machines 1:07:20 - FEALS: Feals Makes CBD Oil Which Satisfies ALL Of Melanie's Stringent Criteria - It's Premium, Full Spectrum, Organic, Tested, Pure CBD In MCT Oil! It's Delivered Directly To Your Doorstep. CBD Supports The Body's Natural Cannabinoid System, And Can Address An Array Of Issues, From Sleep To Stress To Chronic Pain, And More! Go To feals.com/melanieavalon To Become A Member And Get 40% Off Your First 3 Months, With Free Shipping! 1:10:10 - Addressing Emotional Trauma 1:15:50 - Infrared Sauna 1:19:40 - Human Growth Hormone 1:20:15 - Intermittent Fasting 1:22:30 - The Evolution Of Detox Protocols 1:23:40 - Pharmaceutical Chelation 1:26:45 - Challenge Urine Test 1:27:45 - What Can Someone Expect From The Myers Detox Protocol 1:30:10 - Will You Feel Bad During Detox?

GET TRANSCRIPT AND FULL SHOWNOTES: melanieavalon.com/glutathione 2:30 - IF Biohackers: Intermittent Fasting + Real Foods + Life: Join Melanie's Facebook Group At Facebook.com/groups/paleoOMAD For A Weekly Episode GIVEAWAY, And To Discuss And Learn About All Things Biohacking! All Conversations Welcome! 2:45 - Follow Melanie On Instagram To See The Latest Moments, Products, And #AllTheThings! @MelanieAvalon Go To melanieavalon.com/auro With Coupon Code Melanieavalon For 5% Off Site Wide! 3:50 - AVALONX SUPPLEMENTS: Get Melanie's Broad Spectrum Complex Featuring 8 Forms Of Magnesium, To Support Stress, Muscle Recovery, Cardiovascular Health, GI Motility, Blood Sugar Control, Mood, Sleep, And More! Tested For Purity & Potency. No Toxic Fillers. Glass Bottle.  AvalonX Supplements Are Free Of Toxic Fillers And Common Allergens (Including Wheat, Rice, Gluten, Dairy, Shellfish, Nuts, Soy, Eggs, And Yeast), Tested To Be Free Of Heavy Metals And Mold, And Triple Tested For Purity And Potency. Get On The Email List To Stay Up To Date With All The Special Offers And News About Melanie's New Supplements At avalonx.us/emaillist! Get 10% Off avalonx.us And mdlogichealth.com With The Code MelanieAvalon Text "AVALONX" To 877-861-8318 For A One Time 20% Off Code for avalonx.us 5:55 - FOOD SENSE GUIDE: Get Melanie's App At Melanieavalon.com/foodsenseguide To Tackle Your Food Sensitivities! Food Sense Includes A Searchable Catalogue Of 300+ Foods, Revealing Their Gluten, FODMAP, Lectin, Histamine, Amine, Glutamate, Oxalate, Salicylate, Sulfite, And Thiol Status. Food Sense Also Includes Compound Overviews, Reactions To Look For, Lists Of Foods High And Low In Them, The Ability To Create Your Own Personal Lists, And More! 6:40 - BEAUTYCOUNTER: Non-Toxic Beauty Products Tested For Heavy Metals, Which Support Skin Health And Look Amazing! Shop At beautycounter.com/melanieavalon For Something Magical! For Exclusive Offers And Discounts, And More On The Science Of Skincare, Get On Melanie's Private Beautycounter Email List At Melanieavalon.Com/Cleanbeauty Or Text BEAUTYCOUNTER To 877-861-8318! Find Your Perfect Beautycounter Products With Melanie's Quiz: melanieavalon.com/beautycounterquiz 10:30 - Dr. Patel's Background 13:50 - What It's Like Being A Pharmacist In The American System 16:30 - What Is Oxidative Stress? 19:30 - Can We See Oxidative Stress In The Body? 20:10 - How Does The Body Combat Oxidative Stress? 22:50 - Why Did We Lose The Ability To Synthesize Vitamin C Endogenously? 24:10 - Glutathione (GSH) Vs Vitamin C As An Antioxidant 27:20 - How Quickly Can Oxidized GSH Recycle? 29:00 - Different Ways To Supplement GSH? 31:55 - LOMI: Turn Your Kitchen Scraps Into Dirt, To Reduce Waste, Add Carbon Back To The Soil, And Support Sustainability! Get $50 Off Lomi At lomi.com/melanieavalon With The Code MELANIEAVALON! 35:45 - When GSH Is Broken Down Into Amino Acids, Does It Immediately Get Turned Back Into GSH? 36:35 - The 3 Amino Acids That Create GSH 36:50 - Peptide Consumption 41:30 - Does Supplemental GSH Stop Endogenous Production? 45:00 - Alcohol And GSH  45:45 - The Oxidative Stress Of Exercise 49:20 - Should We Be Taking Antioxidants With Exercise? 50:45 - Stress And Free Radicals 51:40 - GSH Creation Of Water 52:10 - GSH And Toxins 53:30 - Heavy Metals In Vitamins 56:10 - IV Vitamin Therapy 56:50 - Corporate Chains That Offer IV Therapy 58:20 - Asking Your Provider 1:00:10 - How Long Does GSH Last In The System 1:03:05 - Mitigating The Side Effect Of Alcohol 1:05:40 - Our Toxic World 1:08:10 - Organics Vs Conventional Produce 1:10:40 - Animal Protein Creating Inflammation 1:13:40 - Antinutrients In Plants 1:15:30 - Is Meat A Good Substrate For GSH? 1:18:15 - LMNT: For Fasting Or Low-Carb Diets Electrolytes Are Key For Relieving Hunger, Cramps, Headaches, Tiredness, And Dizziness. With No Sugar, Artificial Ingredients, Coloring, And Only 2 Grams Of Carbs Per Packet, Try LMNT For Complete And Total Hydration. For A Limited Time Go To drinklmnt.com/melanieavalon To Get A FREE Sample Pack With Any Purchase! 1:24:30 - Pre-Formed GSH 1:26:25 - How Does Auro's GSH Work? 1:26:50 - Storing GSH 1:30:20 - The Smell 1:31:20 - The Half Life Of Auro GSH 1:34:20 - Can Sauna Effect GSH? 1:35:30 - Dosing 1:37:30 - Application 1:38:45 - Why Does GSH Whiten And Brighten Skin? 1:42:30 - Acetyl-Glutathione 1:44:20 - Efficacy Of Application Location With Progesterone 1:48:15 - Suppository Efficacy 1:48:30 - Coffee Enemas 1:49:40 - Testing GSH Levels 1:54:00 - Expectations After Taking GSH Go To melanieavalon.com/auro With Coupon Code Melanieavalon For 5% Off Site Wide!

Visit IFpodcast.com/episode288 For FULL Shownotes, And IFPodcast.com/StuffWeLike For All The Stuff We Like! 1:10 - BUTCHERBOX: For A Limited Time Go To Butcherbox.Com/Ifpodcast And Get One 10-14 Lb Turkey FREE In Your First Box! Go To Yummerspets.Com And Get 10% Off Sitewide With Code MELANIEAVALON! 13:25 - PREP DISH: Get A Free 2-week Trial At prepdish.com/ifpodcast! PREP DISH Makes It Easy To Incorporate The Best Flavors Of The Fall Season - With Gluten Free, Paleo, Super Fast & Low Carb Meal Plans, Grocery, And Recipe Lists!! 15:10 - Listener Q&A: Becca - Benefiber And Psyllium Husk Pills FOOD SENSE GUIDE: Get Melanie's App To Tackle Your Food Sensitivities! Food Sense Includes A Searchable Catalogue Of 300+ Foods, Revealing Their Gluten, FODMAP, Lectin, Histamine, Amine, Glutamate, Oxalate, Salicylate, Sulfite, And Thiol Status. Food Sense Also Includes Compound Overviews, Reactions To Look For, Lists Of Foods High And Low In Them, The Ability To Create Your Own Personal Lists, And More! ​26:35 - Listener Q&A: Samantha - Nutrient Timing? Use Code CYNTHIA30 for $30 off or MEL for $50 off at lumen.me! 39:30 - Listener Q&A: Moose - Struggling with IF 46:15 - AVALONX MAGNESIUM 8: Use The Code Melanieavalon For 10% On Any Order At avalonx.us And mdlogichealth.com! 49:00 - Listener Q&A: Robin - Two Questions Get A Discount At melanieavalon.com/perfectamino With The Code Melanieavalon Our content does not constitute an attempt to practice medicine, and does not establish a doctor-patient relationship. Please consult a qualified health care provider for medical advice and answers to personal health questions.