Podcast appearances and mentions of William G Kaelin

Each October, BCRF-funded investigators are honored at the Foundation’s Symposium & Awards Luncheon in New York City. This year, the program was held virtually, without the lunch—but with all of the important conversations and ideas. The annual event announces the Foundation’s grant investment for the coming year and recognizes BCRF investigators for their trailblazing scientific inquiry. This year’s program included an extraordinary symposium, moderated by BCRF Scientific Director Dr. Judy Garber, that included Dr. Angela DeMichele, Dr. William G. Kaelin Jr. and Dr. Lori J. Pierce. We’re proud to make their discussion available in a special episode of Investigating Breast Cancer.

PharmaPills - Pillole dal farmaceutico: Novità, Curiosità e Lavoro dal mondo del farmaceutico. A cura di Stefano Lagravinese. In questa puntata parliamo di:Bsp Pharmaceuticals, J&J, Premio Nobel, Sperimentazioni cliniche, Malattie rare.Aziende: Bsp Pharmaceuticals, J&J, ViiV Healthcare.Persone: Aldo Braca (Bsp Pharmaceuticals), William G. Kaelin Jr (Harvard Medical School), Peter J. Ratcliffe (Oxford University), Gregg L. Semenza (Johns Hopkins University), Junkik Kim (Boston Children’s Hospital).Nuove terapie: Milasen. Patologie: Lipofuscinosi ceroide neuronale 7.Lavoro: Medical Advisor, CRA II o Senior CRA, CRA II (home based).Il mercoledì alle h 12.00 su Spreaker.com e iTunes.Seguici su: www.telegram.me/pharmapillswww.facebook.com/pharmapills/

PharmaPills - Pillole dal farmaceutico: Novità, Curiosità e Lavoro dal mondo del farmaceutico. A cura di Stefano Lagravinese. In questa puntata parliamo di:Bsp Pharmaceuticals, J&J, Premio Nobel, Sperimentazioni cliniche, Malattie rare.Aziende: Bsp Pharmaceuticals, J&J, ViiV Healthcare.Persone: Aldo Braca (Bsp Pharmaceuticals), William G. Kaelin Jr (Harvard Medical School), Peter J. Ratcliffe (Oxford University), Gregg L. Semenza (Johns Hopkins University), Junkik Kim (Boston Children’s Hospital).Nuove terapie: Milasen. Patologie: Lipofuscinosi ceroide neuronale 7.Lavoro: Medical Advisor, CRA II o Senior CRA, CRA II (home based).Il mercoledì alle h 12.00 su Spreaker.com e iTunes.Seguici su: www.telegram.me/pharmapillswww.facebook.com/pharmapills/

PRESS RELEASE https://www.eurekalert.org/pub_releases/2019-10/ijl-oeb101019.php The 2019 Nobel Prize in Physiology or Medicine has been awarded jointly to Oncotarget Editorial Board Members William G. Kaelin Jr. and Gregg L. Semenza for their discoveries of "how cells sense and adapt to oxygen availability", said the Nobel Committee. The pair was named alongside the UK physician-scientist Sir Peter J. Ratcliffe. The Nobel Committee made the announcement Monday at the Karolinska Institute in Stockholm, Sweden and the discoveries have implications for how we understand and potentially treat a range of conditions like cancer, heart attack, stroke and anemia. The Nobel Laureates identified molecular machinery that regulates the activity of genes in response to varying levels of oxygen. Gregg L. Semenza is a professor of Medicine at Johns Hopkins University and Director of the Vascular Research Program at Johns Hopkins Institute for Cell Engineering. Semenza received the Nobel Prize for the discovery of hypoxia-inducible factor 1 (HIF-1), protein, which controls genes in response to changes in oxygen availability. William G. Kaelin Jr., a Professor of medicine at Harvard Medical School and the Dana-Farber Cancer Institute, earned his share of the Nobel Prize for his work investigating a genetic syndrome called Von Hippel-Lindau's (VHL) disease. Kaelin discovered that the VHL protein prevents the onset of cancer and is involved in the oxygen sensing mechanism through its interaction with HIF-1. The awarded mechanism has a fundamental importance in physiology, and has far-reaching implications for the treatment of lw-oxygen health conditions such as coronary artery disease and tumor growth. ### Both William G. Kaelin and Gregg L. Semenza are founding members of Oncotarget, launched in 2010. Oncotarget is a weekly peer-reviewed open access bio-medical journal covering research on all aspects of oncology. The editors-in-chief are Mikhail (Misha) Blagosklonny and Andrei V. Gudkov. About Oncotarget Oncotarget is a weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology. Oncotarget is published by Impact Journals LLC. To learn more about Oncotarget, please visit http://www.ImpactJournals.com Media Contact: media@oncotarget.com 800.922.0957

On Oct. 7th, 2019, the Nobel Assembly announced that William G. Kaelin, Jr., Dana-Farber Cancer Institute, shares the 2019 Nobel Prize in Physiology or Medicine with Sir Peter J. Ratcliffe of Oxford University and the Francis Crick Institute, and Gregg L. Semenza of Johns Hopkins University, for their discoveries of how cells sense and adapt to oxygen availability. In this episode Tracy interviews Hilary Nicholson, Ph.D., a postdoc research fellow in Kaelin Lab at Dana-Farber Cancer Institute. Hilary talked about her perspectives of Dr. Kaelin receiving the Nobel Prize, how Dr. Kaelin mentors and inspires her, and how her work is built upon this textbook discovery.Hilary is the first author of a recent publication on Science Signaling, "HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species". Kidney cancer is one of the top ten most common forms of cancer in developed countries, and the most common type of kidney cancer is clear cell renal cell carcinoma (ccRCC). The von Hippel-Lindau tumor suppressor gene (VHL) inactivation is associated with ccRCC development, and hypoxia-inducible factor 2 alpha (HIF-2 alpha) is accumulated. Hilary talks about synthetic lethality between CDK4/6 inhibition and VHL loss in two species and across various human ccRCC cell lines in culture and xenografts; The study also shows that HIF-2 alpha was not required for the synthetic lethality. "These findings support testing CDK4/6 inhibitors as treatment for ccRCC, alone and in combination with HIF-2 alpha inhibitors".In addition, Hilary introduced the Science Cheer leaders, a non-profit organization comprised of 300+ current and former NFL, NBA and college cheerleaders pursuing STEM careers.  

“Per le loro scoperte su come le cellule percepiscono e si adattano alla disponibilità di ossigeno”. Così l’Assemblea del Nobel al Karolinska Instituet a Solna, in Svezia, ha appena assegnato il primo degli ambitissimi riconoscimenti attesi per la settimana, il premio Nobel per la medicina e fisiologia 2019, a William G. Kaelin Jr, Sir Peter J. Ratcliffe e Gregg L. Semenza.

北京时间10月7日下午，2019年诺贝尔生理学或医学奖揭晓。奖项授予了美国医学家威廉·凯林（William G. Kaelin Jr.）、英国医学家彼得·拉特克利夫（Sir. Peter J. Ratcliffe）和美国医学家格雷格·塞门扎（Gregg L. Semenza），以表彰他们“发现了细胞如何感知和适应氧气变化机制”。他们将平分900万瑞典克朗（约合人民币650万元）的奖金。

The 2019 Nobel Prize in Physiology or Medicine goes to William G. Kaelin, Jr., Peter J. Ratcliffe and Gregg L. Semenza “for their discoveries of how cells sense and adapt to oxygen availability.” They identified molecular machinery that regulates gene activity in response to changing levels of oxygen.

The 2019 Nobel Prize in Physiology or Medicine goes to William G. Kaelin, Jr., Peter J. Ratcliffe and Gregg L. Semenza “for their discoveries of how cells sense and adapt to oxygen availability.” They identified molecular machinery that regulates gene activity in response to changing levels of oxygen.

Host Kevin Patton summarizes the 2019 Nobel Prize in Physiology or Medicine to three scientists "for their discoveries of how cells sense and adapt to oxygen availability." A special bonus episode. 00:41 | Introduction to Bonus Episode 02:00 | Sponsored by HAPS 02:24 | Summary of Discovery 04:13 | Oxygen at Center Stage 05:24 | HIF Enters the Scene08:08 | Sponsored by AAA 08:26 | VHL - An Unexpected Partner 11:37 | Oxygen sHIFts the Balance 13:20 | Oxygen Shapes Physiology & Pathology 15:15 | Sponsored by HAPI Online Graduate Program 15:48 | Our Course 23:46 | Staying Connected If you cannot see or activate the audio player click here. Questions & Feedback: 1-833-LION-DEN (1-833-546-6336) Follow The A&P Professor on Twitter, Facebook, Blogger, Nuzzel, Tumblr, or Instagram! Singing is like a celebration of oxygen. (Björk)   1 | Introduction to the Bonus Episode 1 minute Kevin introduces the bonus episode, explaining that he's sharing the press release for the 2019 Nobel Prize in Physiology or Medicine. It's chunked for clarity. Press release: The Nobel Prize in Physiology or Medicine 2019. NobelPrize.org. Nobel Media AB 2019. Mon. 7 Oct 2019.   2 | Sponsored by HAPS 2 minutes The Human Anatomy & Physiology Society (HAPS) is a sponsor of this podcast.  You can help appreciate their support by clicking the link below and checking out the many resources and benefits found there. There are a bunch of 1-day regional workshops scattered all over the continent. There's probably one near you coming up this year (or next)! Anatomy & Physiology Society  theAPprofessor.org/haps     3 | Summary of the Discovery 2 minutes 2019-10-07: The Nobel Assembly at Karolinska Institutet has today decided to award the 2019 Nobel Prize in Physiology or Medicine jointly to William G. Kaelin Jr., Sir Peter J. Ratcliffe, and Gregg L. Semenza for their discoveries of how cells sense and adapt to oxygen availability. They identified molecular machinery that regulates the activity of genes in response to varying levels of oxygen.   4 | Oxygen at Center Stage 1 minute During evolution, mechanisms developed to ensure a sufficient supply of oxygen to tissues and cells.   5 | HIF Enters the Scene 3 minutes Gregg Semenza studied the EPO (erythropoietin) gene and how it is regulated by varying oxygen levels. In cultured liver cells he discovered a protein complex that binds to the identified DNA segment in an oxygen-dependent manner. He called this complex the hypoxia-inducible factor (HIF). HIF was found to consist of two different DNA-binding proteins, so called transcription factors, now named HIF-1α and ARNT.   6 | Sponsored by AAA 0.5 minutes A searchable transcript for this episode, as well as the captioned audiogram of this episode, are sponsored by the American Association for Anatomy (AAA) at anatomy.org. Searchable transcript Captioned audiogram      7 | VHL - An Unexpected Partner 3 minutes When oxygen levels are high, cells contain very little HIF-1α. However, when oxygen levels are low, the amount of HIF-1α increases so that it can bind to and thus regulate the EPO gene as well as other genes with HIF-binding DNA segments. See figure (if you can't see it, go to https://my-ap.us/35fm0O6). At about the same time as Semenza and Ratcliffe were exploring the regulation of the EPO gene, cancer researcher William Kaelin, Jr. was researching an inherited syndrome, von Hippel-Lindau's disease (VHL disease). VHL is part of a complex that labels proteins with ubiquitin, marking them for degradation in the proteasome. Ratcliffe and his research group then made a key discovery: demonstrating that VHL can physically interact with HIF-1α and is required for its degradation at normal oxygen levels. This conclusively linked VHL to HIF-1α. When oxygen levels are low (hypoxia), HIF-1α is protected from degradation and accumulates in the nucleus, where it associates with ARNT and binds to specific DNA sequences (HRE) in hypoxia-regulated genes (1). At normal oxygen levels, HIF-1α is rapidly degraded by the proteasome (2). Oxygen regulates the degradation process by the addition of hydroxyl groups (OH) to HIF-1α (3). The VHL protein can then recognize and form a complex with HIF-1α leading to its degradation in an oxygen-dependent manner (4). https://my-ap.us/35fm0O6   8 | Oxygen sHIFts the Balance 1.5 minutes It was also shown that the gene activating function of HIF-1α was regulated by oxygen-dependent hydroxylation. The Nobel Laureates had now elucidated the oxygen sensing mechanism and had shown how it works.   9 | Oxygen Shapes Physiology & Pathology 2 minutes Thanks to the groundbreaking work of these Nobel Laureates, we know much more about how different oxygen levels regulate fundamental physiological processes. For example, muscles, blood vessel formation, immunity, RBC production, placenta development, etc. Oxygen sensing is central to a large number of diseases. For example, patients with chronic renal failure often suffer from severe anemia due to decreased EPO expression. See figure (if you cant's see it, go to https://my-ap.us/2LW2cIb) The awarded mechanism for oxygen sensing has fundamental importance in physiology, for example for our metabolism, immune response and ability to adapt to exercise. Many pathological processes are also affected. Intensive efforts are ongoing to develop new drugs that can either inhibit or activate the oxygen-regulated machinery for treatment of anemia, cancer and other diseases. https://my-ap.us/2LW2cIb   10 | Sponsored by HAPI Online Graduate Program 1 minute The Master of Science in Human Anatomy & Physiology Instruction—the MS-HAPI—is a graduate program for A&P teachers. A combination of science courses (enough to qualify you to teach at the college level) and courses in contemporary instructional practice, this program helps you power up  your teaching. Kevin Patton is a faculty member in this program. Check it out! nycc.edu/hapi     11 | Our Course 8 minutes This set of discoveries touches on many of the core concepts of our course (the big ideas of our story of the human body). Nobel Prizes are a cultural touchstone that students can related to, and thus increase interest and motivation. Nobel Prizes can be a starting point for discussion the role of science in the context of society and culture. Additional resources: Main page for this prize: my-ap.us/31Wuc3Z Publications Semenza, G.L, Nejfelt, M.K., Chi, S.M. & Antonarakis, S.E. (1991). Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene. Proc Natl Acad Sci USA, 88, 5680-5684 my-ap.us/2ontmP8 Wang, G.L., Jiang, B.-H., Rue, E.A. & Semenza, G.L. (1995). Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA, 92, 5510-5514 my-ap.us/2IxLUD5 Maxwell, P.H., Wiesener, M.S., Chang, G.-W., Clifford, S.C., Vaux, E.C., Cockman, M.E., Wykoff, C.C., Pugh, C.W., Maher, E.R. & Ratcliffe, P.J. (1999). The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature, 399, 271-275 my-ap.us/2op4XbP Mircea, I., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J.M., Lane, W.S. & Kaelin Jr., W.G. (2001) HIFa targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing. Science, 292, 464-468 my-ap.us/2IxIf8t Jakkola, P., Mole, D.R., Tian, Y.-M., Wilson, M.I., Gielbert, J., Gaskell, S.J., von Kriegsheim, A., Heberstreit, H.F., Mukherji, M., Schofield, C.J., Maxwell, P.H., Pugh, C.W. & Ratcliffe, P.J. (2001). Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science, 292, 468-472 my-ap.us/35i4wR9   If the hyperlinks here are not active, go to TAPPradio.org to find the episode page. More details at the episode page. Transcript available at the script page. Listen to any episode on your Alexa device. Need help accessing resources locked behind a paywall? Check out this advice from Episode 32 to get what you need! https://youtu.be/JU_l76JGwVw?t=440   Sponsors   Transcript and captions for this episode are supported by the  American Association for Anatomy. anatomy.org     The Human Anatomy & Physiology Society  also provides marketing support for this podcast.  theAPprofessor.org/haps     Distribution of this episode is supported by  NYCC's online graduate program in  Human Anatomy & Physiology Instruction (HAPI)  nycc.edu/hapi   Clicking on sponsor links  helps let them know you appreciate their support of this podcast!   Referrals also help defray podcasting expenses.  Amazon TextExpander Snagit & Camtasia The A&P Professor Logo Items   Follow The A&P Professor on  Twitter, Facebook, Blogger, Nuzzel, Tumblr, or Instagram!   The A&P Professor® and Lion Den® are registered trademarks of Lion Den Inc. (Kevin Patton)