Podcasts about Homeostasis

Send us a textHave you ever felt that gnawing sense of uncertainty that makes your heart race and your mind spiral? That's what we're tackling today—the universal human challenge of dealing with fear.As I reflected on the biblical moment when Christ cried, "My God, why have you forsaken me?", I realized something profound about fear. Often, it's that sense of abandonment—of being utterly alone—that triggers our deepest anxieties. Fear, which I describe as "False Evidence Appearing Real," presents us with illusions that shape our perception and reactions.The way I've learned to handle fear is through what I call our "homeostatic quotient"—maintaining internal balance regardless of external chaos. Take a moment with pen and paper to list everything within your control. This simple exercise shifts focus from what you can't change to what you can, bringing remarkable clarity to an anxious mind. When I catch myself in that spiral of panic, I pause and redirect my thoughts to areas where I have agency.We're living through unprecedented times of disruption and change. Our finances, lifestyles, and relationships face constant pressure as systems evolve at breakneck speed. But perspective is powerful—humans have always adapted. Before our technology-saturated world, people lived fulfilled lives with much less. This reminds us that many of our "necessities" are actually preferences.What gives me the most peace is remembering that God provides in times of abundance and sustains in times of lack. Even the most powerful people on earth sleep—becoming completely vulnerable for hours each day. Who watches over them then? This thought fills me with joy, knowing there's a divine hand guiding us even when we're unaware.If you're struggling with fear today, know this: it's okay to feel afraid, but you don't have to stay there. Faith is the substance of things hoped for, the evidence of things not seen—the perfect antidote to fear's false evidence. Stop comparing yourself to others and remember that He who does not change is with you, becoming your limitless limit.Ready to transform your relationship with fear? Subscribe to the World Cafe podcast for more conversations that will help you navigate life's challenges with faith and practical wisdom.Support the showYou can support this show via the link below;https://www.buzzsprout.com/1718587/supporters/new

Send us a textHave you ever noticed how just before a breakthrough, everything suddenly feels uncertain? That voice of doubt creeps in precisely when you're edging towards the finish line, or when you feel like you've finally cracked through. This isn't a sign you're on the wrong path; it's your brain's natural resistance to change.In this episode, Christina Fletcher shares her personal journey of writing and submitting a dream book proposal to Hay House this summer and the surprising resistance that showed up just before completion. She explores the neuroscience of homeostasis (your brain's way of clinging to what feels familiar) and how to stay aligned even when self-doubt intensifies.Discover how to:Understand and recognize homeostasis and why your brain resists change, even positive changeRecognize the difference between warning signs vs. growth resistanceReframe self-doubt as a sign you're on the edge of transformationAccess your intuition as “future memories”; guidance from your future selfUse small, consistent alignment practices to build resilience during uncertain timesHarness seasonal energy (like September) to anchor in new alignment habitsApply these tools in real-life examples, just like in Christina's manifestation story of meeting her husbandChristina also invites you to join her 5-day In-Flow Challenge starting September 15th. With videos, resources, and community support to help you establish habits that keep you grounded, clear, and aligned with your highest self, she's supporting you in stepping into your aligned self into the busiest season of the year. Join the In-Flow Challenge for FREE here And if you're deprived of sleep and need to rest, don't forget to grab the free Spiritual Sleep Solution Bundle at spirituallyawareliving.com/alignedtosleepChristina Fletcher is a Spiritual Alignment coach, energy worker, author, speaker and host of the podcast Showing Up Whole.She specialises in practical spirituality and integrating inner work with outer living, so you can get self development off of the hobby shelf and integrated as a powerful fuel to your life. Through mindset, spiritual connection, intuitive guidance, manifestation, and mindfulness techniques Christina helps her clients overcome overwhelm and shame to find a place of flow, ease, and deep heart-centered connection.Christina has been a spiritual alignment coach, healer and spiritually aware parent coach for 7 years and trained in Therapeutic Touch 8 years ago. She is also a meditation teacher and speaker. For more information please visit her website www.spirituallyawareliving.com Want to uncover where you need the most energy alignment? Take her new Energy Alignment Quiz to identify which of your energetic worlds (mind, body, heart or spirit) needs aligning the most! Or Follow her on her social media accounts:FacebookInstagramorLinkedin...

Links related to the subjects we touched on this episode:To get the GLUTATHIONE PRECURSOR THAT WE TAKE:https://www.immunotec.com/en-GB/existoradio/products/immunocal https://www.immunotec.com/en-GB/existoradio/studies-and-standardsCONTACT TZEITEL: Instagram: https://www.instagram.com/sublima_health/ Website: sublimahealth.comDOCUMENTARY with Dr. Zach Bush PhDhttps://www.youtube.com/watch?v=t_qx-JzcKWMCONTACT ALEX PINEIRO - Your Existo Radio Host: NEW WEBPAGE COMING SOON existoradio.com with tons of tools to build your own routine.ABOUT THIS EPISODE:September brings daily changes and transitions for everyone. It's evident that it starts to get cooler and school activities resume. Many people take advantage of the start of the calendar to set goals for the new school year. Nature shows us signs: tree leaves change to brown tones and fall; insects seek shelter and build nests; birds migrate to warmer areas. The weather and sunlight also transform. Even the production of fruits and vegetables changes: the earth offers different colors, flavors, and smells, with a more introspective energy. We human beings are in the middle of this inevitable transition that happens every year; in fact, we cannot stop it, we accept it, look at the calendar, and follow that rhythm without questioning it. Now, it is wise for us to adapt to this at levels.Why? To stay in balance.After all, nature always seeks balance, just as our backbone seeks the center to support us. Thus, both nature on a large scale and we humans on a very detailed level are in constant search of balance, physically, mentally, emotionally, and in our spiritual spectrum. To go with the inevitable current of change that nature gives us each year, we can take actions, use tools, and establish our own protocols as daily routines to maintain our balance in this transition. This will be an investment for our immediate and long-term future. Many scientific views affirm, and experience shows, that what we do today reflects in ten years: our habits, our health, our wellbeing.On this Episode, Tzeitel Calle, and I reflect and share information on how we can help and support ourselves to be in balance at all levels: physical, mental, and emotional, because emotions greatly influence our daily lives and decisions. We also want to address the spiritual aspect because we believe we are a whole: mind, body, and spirit, that fundamental triad for the human experience on this planet.Sometimes, the spirit feels like Wi-Fi: invisible but known to be essential, I would say, spiritually speaking, “known to be the essence”. Each person has their perception of spirituality, but it is there, giving meaning and connecting us with a purpose that the mind may not understand. So today, I propose a very practical episode to navigate from heat to cold and its consequences, caring for body, mind, and spirit. Nature is supreme intelligence, and one of its main pillars is finding balance. Our body, being part of this great natural intelligence, is a finely detailed engineering masterpiece, similarly trying to maintain balance among all our systems: up and down, inside and outside, heat and cold, light and shadow, rough and smooth, strong and weak, acid and alkaline... being and not being... This has a name: HOMEOSTASIS. Homeostasis is like the "internal balance" of the body, allowing everything to function well even when outside things change. It is like a superpower that living beings have, to maintain a stable temperature and many other levels to stay alive, which at the end is one of the missions we all have here on this planet. For example, when it is very hot, we sweat to cool down; and when it is cold, we shiver to warm up. This is the product of our wonderful supreme engineering work that is our body. Ideally, each of us, with our circumstances and metrics, can find protocols (routines, tools...) to "return to" or "stay in" balance every day. ABOUT TZEITEL CALLE – Sublima Health. Since she was a kid, Tzeitel has been immersed in Holistic Health, influenced by her stepfather, a homeopathic doctor and nutritionist, and also cultivating an interest in dance and acting. Her professional training began in 2011 with a Higher Technician diploma in Dietetics and Nutrition in Madrid, plus experience in recognized clinics and advanced studies in Coaching and Nutritional Therapy in the UK. She is currently part of the Holistic Nutrition Institute of Madrid, where she is also a tutor, and collaborates giving workshops and consultancies in various centers and events. Her professional approach starts with a detailed analysis of each person's lifestyle and dietary needs, seeking to improve areas like health, weight control, emotional stability, and anxiety, recognizing their interconnection.

Enlaces mencionados en este episodio:Para conseguir el precursor de GLUTATIÓN que tomamos: https://www.immunotec.com/es-ES/existoradio/products/immunocal https://www.immunotec.com/es-ES/existoradio/studies-and-standardsContacta con TZEITEL CALLE:Instagram: https://www.instagram.com/sublima_health/ Web: sublimahealth.com Contacta con ALEX PINEIRO – Tu host de Existo Radio: https://www.instagram.com/exi_s_to/MUY PRONTO existoradio.com con múltiples herramientas para construir tu propia rutina MUY PRONTO!!Septiembre trae consigo cambios cotidianos y transiciones para todas las personas. Es evidente que empieza a refrescar y regresan las actividades escolares.Mucha gente aprovecha el comienzo del calendario para marcarse metas para este nuevo año escolar.Hoy Tzeitel, Calle y yo, reflexionamos y compartimos información sobre cómo podemos ayudarnos y apoyarnos para estar en balance, en todos los niveles: físico, mental y emocional, porque las emociones influyen mucho en nuestro día a día y en nuestras decisiones. También queremos abordar el aspecto espiritual, porque creemos que somos un todo: mente, cuerpo y espíritu, esa triada fundamental para la experiencia humana en este planeta.La Naturaleza está dotada, o es, en sí, inteligencia suprema y uno de sus pilares es el de encontrar equilibrio.Nuestro cuerpo, siendo parte de esta gran inteligencia natural es una obra de ingeniería finamente detallada, obra de la misma manera, tratando de mantener en equilibrio todos nuestros sistemas: entre arriba y abajo, dentro – fuera, calor - frio, luz – sombra, rugoso y suave, fuerte y débil, acido – alcalino… ser y no ser…Esto tiene un nombre: HOMEOSTASIS.La homeostasis es como el "equilibrio interno" del cuerpo, que permite que todo funcione bien incluso cuando cambian las cosas por fuera. Es como un superpoder que tenemos los seres vivos para mantener estable nuestra temperatura, y muchos otros niveles para mantenernos vivos que, al final, es una de las misiones que tenemos aquí todos los que habitamos este planeta. Así, por poner un ejemplo muy palpable, cuando tenemos mucho calor, sudamos para refrescarnos y cuando tenemos frío, temblamos para entrar en calor.Esto es producto de nuestra maravillosa obra de ingeniería suprema que es nuestro cuerpo. Idealmente, cada uno de nosotros con nuestras circunstancias y nuestras métricas, podemos encontrar protocolos (rutinas, herramientas…) para “volver a” o “mantenernos en” equilibrio cada dia

In a fascinating and insightful discussion, I sat down with Dr. Jon Brudvig, a medical scientist and expert in neuroscience and drug development. Together, we explored the science of aging, the critical role of cellular recycling, and the practical steps anyone can take to improve their healthspan. Jon Brudvig shared his journey from rare disease research to longevity science, offering actionable insights into how our daily choices impact the aging process. Such a good conversation, I have split it into two parts. What You'll Learn: The Cellular Foundation of Aging:Discover how Dr. Brudvig’s research into lysosomal storage diseases led him to understand the universal decline in cellular recycling (autophagy and lysosomal function) as a key driver of aging. Autophagy Explained:Learn why autophagy—the body’s process of breaking down and recycling damaged cellular components—is essential for health, and how modern lifestyles can disrupt this natural cycle. The Fundamentals of Longevity:Understand why exercise, diet, sleep, vitamin D, omega-3s, and real-life social connections are the true building blocks of a long and healthy life. Mouse Models and Human Longevity:Gain perspective on the limitations of animal studies in longevity research, and why findings in mice don’t always translate directly to humans. The mTOR Pathway and Protein Intake:Explore the debate around the mTOR pathway, protein consumption, and how balancing periods of growth and rest may be the key to optimal aging. Healthspan vs. Lifespan:Reflect on the difference between living longer and living better, and why increasing your years of good health (healthspan) is a more realistic and valuable goal than chasing extreme longevity. Key Takeaways: Aging is cellular: The decline in lysosomal and autophagy function is a core driver of aging and disease. Autophagy matters: Fasting, exercise, and periodic stressors help trigger the body’s natural recycling processes. Master the basics: Exercise, a balanced diet, quality sleep, and strong social ties are the most effective longevity interventions. Be cautious with quick fixes: Not all supplements or drugs that work in mice will work in humans—focus on proven fundamentals first. Balance is key: Intermittent activation of growth pathways (like mTOR) through meals and exercise, balanced with periods of rest, supports healthy aging. Protein quality counts: Mix your protein sources and prioritise whole foods for optimal health outcomes. Connect with Dr. Jon Brudvig for more insights into longevity and health: LinkedIn: Jon Brudvig Substack: https://jonbrudvig.substack.com/ 00:53 Dr. Brudvig’s Background and PhD Focus01:22 Gene Therapy and Lysosomal Storage Diseases02:45 Connecting Rare Diseases to Aging03:10 Lysosomal Function and Aging03:40 Professional Work in Drug Development04:01 The Link Between Professional and Personal Interests04:22 The Role of Lysosomes in Autophagy04:40 What is Autophagy?04:54 Why Autophagy Matters for Cellular Health05:07 The Recycling Analogy: Cells as Master Recyclers05:26 Evolutionary Importance of Autophagy06:14 Autophagy, Fasting, and Modern Lifestyles07:07 The Impact of Modern Comfort on Health07:28 Social Media, Longevity, and Biohacks08:00 The Interventions Testing Program Explained08:42 Mouse Studies and Their Limitations09:32 The Importance of Fundamentals: Exercise, Diet, Sleep10:22 Omega-3s and Social Networks for Longevity11:00 The Hallmarks of Aging11:40 Homeostasis and the Aging Process12:20 Healthspan vs. Lifespan: Which Matters More?13:07 The Two Camps in Longevity Science13:51 Promising Interventions: SGLT2 Inhibitors and Rapamycin14:45 Rapamycin: Hype, Dosing, and Human Application15:53 mTOR Pathway, Protein Intake, and Longevity17:00 Balancing mTOR Activation and Autophagy18:00 Practical Protein Advice: Whey, Collagen, and Plant-Based Sources18:45 Final Thoughts: Eat Real Food and Mix Protein Sources See omnystudio.com/listener for privacy information.

If you're curious as to if you have any stored emotions or trauma that might be causing your illness, preventing you from achieving your or even just showing up as the best, authentic version of yourself, I invite you to take my free Stored Emotions and Trauma Quiz In this episode, I share why emotional and quantum healing do not mean ignoring diet and lifestyle.I talk about a client who admitted she'd rather skip diet and lifestyle changes and asked if focusing on emotional healing was enough, and why I told her these areas are deeply connected and shouldn't be separated. I walk through how treating your body like a temple can look different depending on your stage of life and healing, why energy and vibration, both personal and environmental, affect your health, and how listening to your body's cues matters more than following trends. I share my own short-term diet resets, hormone adjustments, and experiences with different environments, and why finding what works for you is key.You'll Learn:Why your body is truly a temple and should be treated that wayHow energy and vibration matter, both the energy we carry and the energy around us.Why it's important to listen to your body cues and intuitionThe real reason emotional and quantum healing can't be separated from diet and lifestyleWhy treating your body like a temple looks different at different points in your lifeHow food quality and movement form the foundation for emotional balance and spiritual growthWhat it feels like to reset your body with short-term dietary changesThe quiet damage of ignoring your body's early warning signsHow your thoughts and the people around you shape your vibrational stateWhy your body's cues and intuition are more reliable than health trendsThe impact of location and surroundings on your energy and moodWhat changes when you release stored emotions and traumaTimestamps: [00:00] Introduction [05:59] Why science, spirituality, and religion were intentionally separated [07:39] How your focus on physical, emotional, and spiritual health shifts over time [09:55] Why diet and lifestyle form the foundation for emotional and spiritual healing [13:42] Core lifestyle habits that support long-term health [17:00] How personal energy, thoughts, and environment shape your wellbeing [23:00] The impact of location and surroundings on your energy [28:07] Why your way is the right way when it comes to healing [32:00] How clearing symptoms helps you hear your body's cuesFind More From Dr. Stephanie Davis:Dr. Stephanie Davis | WebsiteQuantum Rx | InstagramQuantum Rx | Skool

Your dopamine system is being hijacked every day, and the way to reclaim it might surprise you. This episode reveals how pain, pleasure, and addiction are wired in your brain, and how to use that knowledge for real brain optimization, resilience, and longevity. You'll discover why your dopamine levels control motivation, focus, mood, and even cravings—and the science-backed strategies that reset your neuroplasticity, metabolism, and reward system. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Anna Lembke, Stanford psychiatrist and bestselling author of Dopamine Nation. She is one of the world's leading experts on addiction, compulsive behavior, and the neuroscience of reward pathways. With decades of clinical work and groundbreaking research, she explains why dopamine has become the modern lens for understanding desire, distraction, and dysfunction—and how we can hack it to upgrade human performance. They break down how dopamine drives addiction, why pain can reset your reward system, and how simple practices like fasting, cold therapy, and supplements affect your brain chemistry. You'll learn how nicotine, GLP-1 drugs, and even nootropics alter dopamine sensitivity, and why overstimulation from social media, pornography, and ultra-processed food is creating an epidemic of anhedonia. The conversation also covers how functional medicine and biohacking can protect your mitochondria, restore your natural dopamine balance, and make your brain more resilient. You'll Learn: • Why dopamine itself is not addictive—and what really drives addiction • How pain, hormesis, and “dopamine fasting” can reset your reward system • Why social media and digital overstimulation create chronic dopamine deficit states • The role of GLP-1 drugs, nicotine, psychedelics, and other substances in rewiring dopamine • How functional medicine and supplements help restore dopamine balance • The connection between dopamine, mitochondria, fasting, cold therapy, and longevity • Why radical honesty and self-binding are powerful anti-addiction hacks This is essential listening for anyone serious about hacking dopamine for better focus, sleep optimization, metabolism, and long-term brain health. Whether you're curious about the link between dopamine and neuroplasticity, looking to upgrade human performance with smarter not harder tools, or just want to know how to stop dopamine hijacks from ruling your life, this episode gives you the science and strategies you need. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Keywords: dopamine fasting, pleasure-pain balance, dopamine deficit state, addiction neurobiology, anhedonia treatment, dopamine receptors, neuroadaptation gremlins, endogenous opioids, cold plunge dopamine, hormesis neuroscience, nucleus accumbens dopamine, L-Dopa addiction, GLP-1 and dopamine, social media addiction neuroscience, dopamine reward pathway, compulsive behavior psychiatry, dopamine and neuroplasticity, anhedonia supplements, functional medicine addiction, dopamine repair party Thank you to our sponsors! Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. Resources: • Anna's Website: https://www.annalembke.com/ • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:10 — Introduction 5:47 — Pleasure–Pain Balance 6:45 — Homeostasis & Adaptation 8:22 — Addiction & Dopamine Deficit 10:14 — BICEP: Conscious Pain Exposure 14:26 — Adapting to Pleasure & Pain 20:20 — GLP-1s and Joy 21:39 — Modern Anhedonia 34:32 — Resilience in Young People 42:00 — Social Media & Mental Health 44:46 — Control & Addiction 55:14 — Dopamine Fasting 1:03:18 — Self-Binding Tools 1:07:56 — Psychedelics & Addiction 1:12:25 — Parenting in the Digital Age 1:14:39 — Progress & Outlook See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Send us a textIn this thought-provoking episode of the Autonomic Homeostasis Activation Podcast, Ruth Lorensson and Thomas Pals welcome back Scott Turner, renowned physiologist and expert on homeostasis, cognition, and superorganisms, for a deep dive into the science and mystery behind Autonomic Homeostasis Activation (AHA).Together, they explore the fascinating intersection of interoception, homeostasis, and the autonomic nervous system, unpacking how AHA may help reframe conditions like PTSD, anxiety, depression, Crohn's disease, and autoimmune disorders. Scott shares insights from his research on termite colonies, superorganisms, and the many little lives within the body, showing how persistent homeostatic states—whether healthy or unhealthy—can be shifted through new conversations at the cellular and cognitive level.Listeners will discover:What AHA (Autonomic Homeostasis Activation) really is and how it works.Why combining homeostasis activation with interoceptive awareness produces powerful outcomes.How disease and wellness can be understood as conversations within the body.Parallels between biological cognition, consciousness, and collective intelligence.Why anecdotal evidence and case studies are vital in exploring emerging therapies.This conversation bridges science, wellness, and biomimicry, offering a hopeful lens on healing, resilience, and the neurobiological roots of human thriving.Support the showThanks for listening!You can follow us onFacebook Instagram Leave us a review on Apple Podcasts Check out the Autonomic Healing Website & InnerWorkings WebsiteEmail Tom thomasjpals@innerworkings.orgEmail Ruth ruth@bridgeandrhino.comSupport usWe appreciate you!

teve Butts, Co-Founder and CEO of Arrivo BioVentures, is a biopharmaceutical company focused on developing therapies that target the root causes of disease rather than just treating the symptoms. Their drugs treat major depressive disorder and acute pancreatitis through novel epigenetic mechanisms of action. Sex-based differences were observed in clinical trials where the drug SP-624 showed efficacy in females but not in males, which could lead to a paradigm shift in how depression is treated in men and women. Steve explains, "We've evolved over time at Arrivo and with our previous companies. What we're excited about right now is the fact that we have two drugs. One called SP-624 or Forvisirvat is the generic name, and the other one is code-named RABI-767. And as we've gotten into the science behind these drugs, what we're finding is that we're not just treating the symptoms of a disease, but we're really trying to get at what's causing the disease fundamentally and trying to make an impact there. And I think from a drug development standpoint - I've been doing this for 30 years - these are the two most exciting programs that I've had a chance to work on for a variety of reasons. One is the science, and they're both novel and new approaches to treating the diseases, but two, if we're right, they're going to create a situation where we're going to think about these diseases differently." "We ran a large Phase 2 study. It was the first study we had run in patients with depression, and it was really the first study that anyone had run with a SIRT6 activator in patients with depression. And so we were breaking new ground there, and it was a pretty large study. When we got the results, what we found was that there were really nice effects in females across all of the measures that we had and no evidence of efficacy in males. And that was really puzzling to us. It wasn't what we were expecting. And we started diving into, well, what could be going on here? Science is iterative, and I think you do a trial, and trials lead to more questions. And so we started diving into the questions that we had around “Why the sex difference?” #ArrivoBioVentures #MentalHealth #Neuroscience #WomensHealth #Depression #DepressionTreatment #Psychiatry #PrecisionMedicine arrivobio.com Listen to the podcast here

Steve Butts, Co-Founder and CEO of Arrivo BioVentures, is a biopharmaceutical company focused on developing therapies that target the root causes of disease rather than just treating the symptoms. Their drugs treat major depressive disorder and acute pancreatitis through novel epigenetic mechanisms of action. Sex-based differences were observed in clinical trials where the drug SP-624 showed efficacy in females but not in males, which could lead to a paradigm shift in how depression is treated in men and women. Steve explains, "We've evolved over time at Arrivo and with our previous companies. What we're excited about right now is the fact that we have two drugs. One called SP-624 or Forvisirvat is the generic name, and the other one is code-named RABI-767. And as we've gotten into the science behind these drugs, what we're finding is that we're not just treating the symptoms of a disease, but we're really trying to get at what's causing the disease fundamentally and trying to make an impact there. And I think from a drug development standpoint - I've been doing this for 30 years - these are the two most exciting programs that I've had a chance to work on for a variety of reasons. One is the science, and they're both novel and new approaches to treating the diseases, but two, if we're right, they're going to create a situation where we're going to think about these diseases differently." "We ran a large Phase 2 study. It was the first study we had run in patients with depression, and it was really the first study that anyone had run with a SIRT6 activator in patients with depression. And so we were breaking new ground there, and it was a pretty large study. When we got the results, what we found was that there were really nice effects in females across all of the measures that we had and no evidence of efficacy in males. And that was really puzzling to us. It wasn't what we were expecting. And we started diving into, well, what could be going on here? Science is iterative, and I think you do a trial, and trials lead to more questions. And so we started diving into the questions that we had around “Why the sex difference?” #ArrivoBioVentures #MentalHealth #Neuroscience #WomensHealth #Depression #DepressionTreatment #Psychiatry #PrecisionMedicine arrivobio.com Download the transcript here

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Send us a textIn this thought-provoking conversation, Ruth Lorensson and Thomas Pals welcome back Scott Turner, author of Purpose and Desire, to explore the fascinating intersections of niche construction theory, homeostasis, and human wellness. Together, they unpack how living systems—down to the cellular level—act with agency, intentionally shaping and being shaped by their environments.From Walter Cannon's classic definition of homeostasis to Aristotle's ideas on purposefulness, the discussion bridges evolutionary biology, biophysics, and wellness science. Scott Turner explains why adaptation is more than mechanistic feedback loops—it's about purposeful striving at every level, from microbiomes to ecosystems. The trio dives deep into the “many little lives” metaphor, revealing how cellular conversations influence our overall health, vitality, and resilience—and how disruption in those conversations can lead to illness, cancer, and even addiction.Key topics include:The agency of living systems and its role in adaptation and wellnessHow niche construction theory challenges modern DarwinismWhy homeostasis is misunderstood and how it truly operatesThe parallels between ecosystem health and human healthThe role of interoception in restoring balance and fostering well-beingWhether you're a wellness professional, leader, or simply curious about the science of thriving, this episode offers a fresh lens on what it means to be well—and how to consciously participate in the adaptive conversations that sustain life.Support the showThanks for listening!You can follow us onFacebook Instagram Leave us a review on Apple Podcasts Check out the Autonomic Healing Website & InnerWorkings WebsiteEmail Tom thomasjpals@innerworkings.orgEmail Ruth ruth@bridgeandrhino.comSupport usWe appreciate you!

In this Huberman Lab Essentials episode, I discuss both healthy eating and clinically recognized eating disorders, including anorexia, bulimia and binge eating disorder. I explain how brain circuits, hormones such as leptin and reward systems interact to regulate appetite, satiety and overall eating behaviors. I also discuss the serious health risks associated with anorexia, explain how disrupted eating habits contribute to its development and highlight evidence-based treatments for anorexia. Finally, I explore binge eating and bulimia, discussing the underlying causes and the pharmacological treatments commonly used to support recovery. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman LMNT: https://drinklmnt.com/huberman Function: https://functionhealth.com/huberman Timestamps 00:00:00 Eating Disorders 00:01:05 Fasting, Intermittent Fasting, Healthy Eating 00:06:10 Self-Diagnosis Caution 00:07:20 Sponsor: LMNT 00:08:52 Eating Disorders, Anorexia Nervosa 00:12:39 Hunger & Satiety; Appetite, Body Fat & Brain 00:17:20 Homeostasis & Reward Systems, Eating Disorders 00:21:12 Sponsor: AG1 00:22:49 Anorexia, Puberty, Hyperacuity & Food 00:25:55 Decision-Making vs Reflexes/Habits, Anorexia 00:29:29 Anorexia & Breaking Habits, Therapies & Family-Based Models 00:32:08 Distorted Self-Image & Anorexia 00:35:03 Sponsor: Function 00:36:43 Bulimia & Binge-Eating Disorder, Impulsivity & Prescription Treatments 00:40:28 Recap & Key Takeaways Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode we delve deep into science to hear about Professor Ian Ganley's ground-breaking research in the field of mitophagy, one of the body's self cleaning mechanisms that could play a key role in the development of Parkinson's. Not only is Professor Ganley making strides forward in what we know about the process, but his team have invented a prize winning new tool that has revolutionised the pace of progress in this immensely promising area of research worldwide. Further reading: https://www.ppu.mrc.ac.uk/research/principal-investigator/ian-ganley Prof. Ganley's paper on the effects of LRRK2 mutations in mitophagy: https://elifesciences.org/articles/67604

Struggling with thyroid belly that won't budge despite being told your TSH is "normal" or "optimized"? Dr. Eric Balcavage reveals why 70% of people on thyroid medication were put on it inappropriately and why T3 medication often makes things worse. Discover the difference between homeostasis vs. allostasis and why your cells aren't broken—they're adapting. Key Topics Covered: Why thyroid optimization fails vs. true thyroid recovery The cell danger response and allostatic regulation Why more T4/T3 medication often worsens symptoms Strategic Thyroid Recovery Blueprint approach 18 Fitness Factors assessment for root cause analysis Escaping "thyroid purgatory" for good RESOURCES: Fitness Factor Assessment: DM "fitness" on Instagram @drericbalcavage • Thyroid Recovery Blueprint: www.drericbalcavage.com Free Discovery Call: www.drericbalcavage.com TIMESTAMPS: 0:06 - Why thyroid belly persists despite "normal" labs 2:44 - Modern thyroid care failures (conventional vs functional) 4:22 - SHOCKING: 70% inappropriate thyroid prescriptions 8:21 - Blood levels vs cellular physiology disconnect 10:29 - HOMEOSTASIS vs ALLOSTASIS explained 15:16 - Why doctors fail despite "optimizing" labs 17:29 - "Thyroid purgatory" concept 18:23 - Why there's no optimal thyroid hormone dose in allostasis 21:21 - Strategic Thyroid Recovery Solution 22:44 - 18 Fitness Factors assessment (DM "fitness" for free copy) 26:39 - Strategic supplementation approach 30:07 - T3 medication controversy: 5-10 mcg max 32:30 - HOPE: Thyroid belly is NOT a life sentence 33:03 - Action steps & free resources #ThyroidBelly #HypothyroidSymptoms #ThyroidRecovery #CellularHypothyroidism #AllostaticRegulation #StrategicThyroidSolution #ThyroidPurgatory

Maintaining internal stability in the face of life's relentless chaos, homeostasis is your body's way of keeping things boring—which, fortunately, is perfect for sleep. From blood sugar to body temp, it's all about not rocking the boat. Ideal for bedtime stories, relaxation, and insomnia relief. Want More? Request a topic: https://www.icantsleeppodcast.com/request-a-topic Listen ad-free & support the show: https://icantsleep.supportingcast.fm/ Shop sleep-friendly products: https://www.icantsleeppodcast.com/sponsors Join the discussion on Discord: https://discord.gg/myhGhVUhn7 This content is derived from the Wikipedia article on Homeostasis, available under the Creative Commons Attribution-ShareAlike (CC BY-SA) license. Read the full article: Wikipedia - Homeostasis. Learn more about your ad choices. Visit megaphone.fm/adchoices

To receive my free and daily newsletter, go to: www.SmartDigestion.com Would you like to schedule a consultation? Call 586-685-2222 To try Dr. Christine's Smart Carb-45 for go to: www.TrySmartCarb.com

To receive my free and daily newsletter, go to: www.SmartDigestion.com Would you like to schedule a consultation? Call 586-685-2222 To try Dr. Christine's Smart Carb-45 for go to: www.TrySmartCarb.com

To receive my free and daily newsletter, go to: www.SmartDigestion.com Would you like to schedule a consultation? Call 586-685-2222 To try Dr. Christine's Smart Carb-45 for go to: www.TrySmartCarb.com

In this episode of the Athletes Compass, Paul Laursen, Marjaana Rakai, and Paul Warloski navigate the overwhelming world of training advice by highlighting six core pillars for endurance performance: base training, HIIT, strength training, sleep/recovery, nutrition, and mental health. They discuss how to recognize when you're out of balance, why "feel" matters more than metrics, and how even elite athletes use intuition to guide training. With humor, science, and real-life examples, they deliver a grounded framework to help everyday athletes train effectively and sustainably. Key Episode TakeawaysHomeostasis (Balance) is the ultimate goal—stress is necessary but must be counterbalanced by recovery.Base Training is essential for building metabolic flexibility and long-term adaptation.Feel Over Metrics: Even top athletes prioritize how their body feels over data.HIIT and Strength Training provide necessary stressors for growth but should be used strategically.Sleep and Nutrition are recovery pillars often overlooked but critical for adaptation.Mental Health and Community amplify both performance and well-being.Red Flags in training include fatigue, poor sleep, emotional irritability, and poor HRV trends.Avoid Trends that don't serve your individual context—personalization is key.Complete the FIELD Study Questionnaire - Join the FIELD Study — a real-world research project that brings Sports Science 3.0 to life.Paul Warloski - Endurance, Strength Training, YogaMarjaana Rakai - Tired Mom Runs - Where fitness meets motherhood.

To receive my free and daily newsletter, go to: www.SmartDigestion.com Would you like to schedule a consultation? Call 586-685-2222 To try Dr. Christine's Smart Carb-45 for go to: www.TrySmartCarb.com

Send us a textIn this episode of the Autonomic Homeostasis Activation Podcast, Ruth Lorensson and Tom Pals dive deep into the fascinating relationship between the brain and the mind, unpacking how they work together to achieve wellness in body, mind, and spirit. They explore how the brain functions as a powerful sensory tool—capable of guiding us toward homeostasis and healing—while the mind shapes our experiences and perceptions.Tom explains the crucial distinction between the brain's wisdom and the mind's interpretive processes, discussing concepts like interoception, subconscious influence, and the importance of allowing the brain to inform the mind. Ruth shares personal insights on how understanding this dynamic has empowered her own wellness journey, including a powerful example from her daughter's study experience. Together, they highlight why truly understanding the brain's role is vital for wellness and stress management.Tune in for a thought-provoking conversation on how these two systems, when in harmony, help us thrive. Don't miss out on practical takeaways to shift from a reactive, mind-driven approach to a more holistic, brain-informed path to well-being.Key Topics:The difference between the brain and the mindInteroception and its role in homeostasisHow subconscious influences shape our thoughts and behaviorsPractical insights for activating brain wellnessJoin Ruth and Tom as they unravel these fascinating concepts and guide you toward a deeper understanding of your body's wisdom.Support the showThanks for listening!You can follow us onFacebook Instagram Leave us a review on Apple Podcasts Check out the Autonomic Healing Website & InnerWorkings WebsiteEmail Tom thomasjpals@innerworkings.orgEmail Ruth ruth@bridgeandrhino.comSupport usWe appreciate you!

Support the show to get full episodes, full archive, and join the Discord community. The Transmitter is an online publication that aims to deliver useful information, insights and tools to build bridges across neuroscience and advance research. Visit thetransmitter.org to explore the latest neuroscience news and perspectives, written by journalists and scientists. Read more about our partnership. Sign up for Brain Inspired email alerts to be notified every time a new Brain Inspired episode is released. To explore more neuroscience news and perspectives, visit thetransmitter.org. You may have heard of the critical brain hypothesis. It goes something like this: brain activity operates near a dynamical regime called criticality, poised at the sweet spot between too much order and too much chaos, and this is a good thing because systems at criticality are optimized for computing, they maximize information transfer, they maximize the time range over which they operate, and a handful of other good properties. John Beggs has been studying criticality in brains for over 20 years now. His 2003 paper with Deitmar Plenz is one of of the first if not the first to show networks of neurons operating near criticality, and it gets cited in almost every criticality paper I read. John runs the Beggs Lab at Indiana University Bloomington, and a few years ago he literally wrote the book on criticality, called The Cortex and the Critical Point: Understanding the Power of Emergence, which I highly recommend as an excellent introduction to the topic, and he continues to work on criticality these days. On this episode we discuss what criticality is, why and how brains might strive for it, the past and present of how to measure it and why there isn't a consensus on how to measure it, what it means that criticality appears in so many natural systems outside of brains yet we want to say it's a special property of brains. These days John spends plenty of effort defending the criticality hypothesis from critics, so we discuss that, and much more. Beggs Lab. Book: The Cortex and the Critical Point: Understanding the Power of Emergence Related papers Addressing skepticism of the critical brain hypothesis Papers John mentioned: Tetzlaff et al 2010: Self-organized criticality in developing neuronal networks. Haldeman and Beggs 2005: Critical Branching Captures Activity in Living Neural Networks and Maximizes the Number of Metastable States. Bertschinger et al 2004: At the edge of chaos: Real-time computations and self-organized criticality in recurrent neural networks. Legenstein and Maass 2007: Edge of chaos and prediction of computational performance for neural circuit models. Kinouchi and Copelli 2006: Optimal dynamical range of excitable networks at criticality. Chialvo 2010: Emergent complex neural dynamics.. Mora and Bialek 2011: Are Biological Systems Poised at Criticality? Read the transcript. 0:00 - Intro 4:28 - What is criticality? 10:19 - Why is criticality special in brains? 15:34 - Measuring criticality 24:28 - Dynamic range and criticality 28:28 - Criticisms of criticality 31:43 - Current state of critical brain hypothesis 33:34 - Causality and criticality 36:39 - Criticality as a homeostatic set point 38:49 - Is criticality necessary for life? 50:15 - Shooting for criticality far from thermodynamic equilibrium 52:45 - Quasi- and near-criticality 55:03 - Cortex vs. whole brain 58:50 - Structural criticality through development 1:01:09 - Criticality in AI 1:03:56 - Most pressing criticisms of criticality 1:10:08 - Gradients of criticality 1:22:30 - Homeostasis vs. criticality 1:29:57 - Minds and criticality

Hair Analysis is the basis of Dr. Prather's evaluation of a patient's mental health issues, because it is the best way to measure their body's mineral levels and heavy metal toxicities.  In fact, Dr. Prather says that, if he can get a Hair Analysis on a patient, "probably 95% of the mental health issues go away".  In this episode, find out:—Why the hair reflects what is going on in the brain and in the nervous system.  And the "transformative change in people's mental health" when you "get the minerals back in Homeostasis and the heavy metals out of the system".—How the most common heavy metal toxicity Dr. Prather sees is Aluminum, which "poisons the brain" and is linked to Dementia, Alzheimer's, Osteoporosis, balance problems, aggressive behavior in children, ADHD, Autism, and Insomnia.—The problems caused by Lead, Mercury, and Nickel for mental health.  And why Dr. Prather says that Nickel is "even worse" than those toxicities and is always something he checks for on patients with severe upper motor neuron diseases like Multiple Sclerosis and ALS.—The CDC study that showed 65% of all children have some sort of heavy metal toxicity.  And how Dr. Prather has had "kids go from Special Ed. to Honors, just by getting their heavy metals out and balancing out their minerals".—How an imbalance in the Copper-Zinc ratio can lead to issues like Anxiety, Attention Deficit, Dementia, Depression, and Insomnia.  And how high Copper is more common in females than males. —The link between high Manganese and Bi-Polar, Parkinson's symptoms, and tremors.  And the importance of a proper Calcium-Magnesium ratio. —Why Dr. Prather says that you can do everything possible, but are "never going to get a person's mental health issues under control until you get rid of those heavy metal toxicities". —How Dr. Prather uses a gentle and natural detoxification process for heavy metal toxicities that is "much more effective" than Chelation, which can be damaging to the Kidneys and Liver and deplete the body of minerals.—Why Amish men who do woodworking are in danger of high Arsenic levels, which can cause Anxiety, mood disorders, antagonistic personality, Depression, and Insomnia. —Dr. Prather's surprising discovery about the importance of low Molybdenum, which can cause fatigue, Depression, and can cause someone to become so tired that they can't even sleep.http://www.TheVoiceOfHealthRadio.com

To receive my free and daily newsletter, go to: www.SmartDigestion.com Would you like to schedule a consultation? Call 586-685-2222 To try Dr. Christine's Smart Carb-45 for go to: www.TrySmartCarb.com

In this episode, Dr. Christine reviews 3 powerful protein insights. To get your free call visit: www.bit.ly/gutcall For any questions call 586-685-2222

Are negative-feedback loops really the body's default setting?

In this episode, Simon Goode explores how we can "digest" conflict experiences by using practical self-regulation techniques in the moment, immediately after, and over the long term. He shares tools like mindful breathing, multisensory walks, journaling, and gratitude exercises to help restore balance and process stressful encounters. Simon emphasizes that everyone's needs are different, encouraging listeners to experiment with various strategies to find what works best for them.--------------- TIMESTAMPS: 00:00 Mind-Body Self-Regulation Transformation04:32 Digesting Conflict: Strategies and Tools06:25 Navigating Advice Sensitively11:00 "Understanding Sensory and Internal Perception"15:33 Post-Conflict Reset Strategies18:19 The 20 Sigh Method21:04 Simple Mindfulness Techniques23:24 "Emotional Impact of Childhood Sounds"29:32 Mindfulness Habits: Overcoming Doubts32:01 "Benefits of Pen-and-Paper Journaling"36:05 Gratitude: A Path to Positivity39:10 "Staying Calm: Practical Strategies"41:50 Podcast Farewell MessageClick here to send me a quick message via FanMailSupport the showwebsite: simongoode.com email: podcast@simongoode.com

Welcome to the 26th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications.  This episode features a discussion with first author Dr Marios Kritsilis and senior author Associate Professor Iben Lundgaard of the Brain article entitled: Loss of glymphatic homeostasis in heart failure This academic duo from Lund University discuss their fascinating findings exploring glymphatic homeostasis in a mouse model of heart failure. Counter-intuitively, there may be more influx but not efflux associated with reduced ejection fraction. This has interesting implications on heart failure associated cognitive changes and risk of developing dementia.  Check out the full article on the Brain website as part of the March 2025 issue: https://doi.org/10.1093/brain/awae411 This episode was co-hosted, edited and produced by Xin You Tai and Roberto Bellanti, co-produced by Antonia Johnston, original music by Ammar Al-Chalabi.

In this episode of the Radically Well podcast we delve into the dynamics of relationships, and the journey of resilience. Special guests; Jeff Krasno and Schuyler Grant discuss their personal experiences with therapy, conflict resolution, and the impact of chronic ease on health. They emphasize the significance of discomfort in personal growth and the need for awareness in navigating modern conveniences. They discuss the importance of emotional health, co-regulation, and the necessity of discomfort for growth.  If you're ready to ready to explore how discomfort can fuel personal growth, strengthen relationships, and transform your well-being, this episode is for you! Three reasons to listen to the entire episode: 1. How to Cultivate Emotional Health & Strong Relationship with deep listening, and conflict resolution to build resilience, strengthen connections, and embrace the power of interdependence. 2. How to Embrace Change & Personal Growth. Recognize that discomfort fuels transformation, adaptability enhances wellness, and you have the power to influence your own evolution. 3. How to Achieve Balance & Optimal Health. Stay aware of your habits, embrace stress as a tool for growth, and strive for balance through mindful practices like yoga and self-care. Timestamps: (00:00:00) Introduction (00:06:00) Exploring the Need for Therapy (00:09:06) Navigating Relationships and Conflict Resolution (00:12:04) The Journey of Resilience in Relationships (00:15:59) Building Community and Collaboration (00:17:58) The Impact of Chronic Ease on Health (00:20:53) The Role of Discomfort in Growth (00:23:48) The Importance of Awareness in Health (00:26:52) The Journey of Personal Transformation (00:30:08) Understanding Chronic Dis-ease (00:32:51) The Challenge of Modern Convenience (00:36:12) The Power of Change and Agency (00:45:15) The Nature of Change and Interdependence (00:48:58) Bridging Science and Mysticism (00:50:32) Co-Regulation and Emotional Health (00:54:15) The Dance of Balance and Homeostasis (00:60:57) Finding Wellness Through Discomfort (01:07:00) The Teeter-Totter of Life (01:16:48) Embracing Discomfort for Growth (01:34:29) The Power of Listening and Presence (01:27:18) Defining Wellness in a Changing World Resources: Radically Loved Ep 543 https://youtu.be/_0Ax7l8IJwQ?si=hA-toplD5bRnqe0R Good Stress pre-order page: https://onecommune.mykajabi.com/goodstressbook?preview_theme_id=2159005940 Luminescence https://www.onecommune.com/luminescence Good Stress pre-order page on Amazon: https://www.amazon.com/Good-Stress-Health-Benefits-Things/dp/1401993958 Jeff Krasno Instagram: https://www.instagram.com/jeffkrasno/?hl=en Schuyler Grant Instagram: https://www.instagram.com/schuylergrantyoga/?hl=en Enjoy the Podcast? If you felt radically well from listening to this podcast, subscribe and share it with the people you love! Love to give us 5 stars? If you do, we'd love a review from you. Don't forget to follow and message us on these platforms! Instagram: https://www.instagram.com/rosieacosta/ Twitter: https::twitter.com/rosieacosta Facebook: https://www.facebook.com/radicallylovedrosie TikTok: https://www.tiktok.com/@itsrosieacosta Website: https://www.radicallyloved.com/ Get You Are Radically Loved the book: https://www.radicallyloved.com/book Try Headspace for 30 days free! use code: ROSIE30 www.headspace.com Sign up for 'The Mindful Love Hub' on Substack: https://radicallyloved.substack.com?utm_source=navbar&utm_medium=web&r=2t314w Create a daily meditation ritual in just seven days! Download BUILD YOUR DAILY MEDITATION RITUAL and other freebies at https://www.radicallyloved.com/free-stuff! Connect with Tessa Tovar: Website: https://tessatovar.com YouTube: https://www.youtube.com/channel/UCHMYm-7kNZfulgaiCi2w8Cw Book of Poetry for Savasana: https://www.amazon.com/Dark-Moon-Book-Poetry-Savasana/dp/1731243588

Send us a textIs achieving balance really the key to wellness? Or have we misunderstood homeostasis all along? In this eye-opening episode of the Autonomic Homeostasis Activation Podcast, hosts Tom Pals and Ruth Lorensson dive deep into the science of homeostasis and uncover why true wellness isn't about achieving perfect equilibrium—it's about thriving in dynamic disequilibrium.They break down the history of homeostasis, from Walter Cannon's groundbreaking research to modern-day misunderstandings that could be holding us back in our pursuit of health and resilience. Learn how your body naturally adapts to constant change, why chasing "balance" can be counterproductive, and how embracing the natural fluctuations of life can lead to greater well-being in mind, body, and spirit.Join the conversation as we challenge conventional wellness wisdom and explore how to work with change, rather than against it.

Ever feel like your body is working against you when it comes to weight loss? In this episode, I unpack the fascinating concept of homeostasis—our body's natural way of maintaining balance—and how it plays a critical role in our eating habits, cravings, and metabolism. I'll break down why extreme dieting backfires, how dopamine influences our food choices, and what we can do to work with our body instead of fighting against it. We'll also explore the power of pain—yes, pain!—and how embracing the right kind of discomfort can actually help us create lasting change. Drawing from the research of Dr. Anna Lembke, I'll share strategies to reset our brain's reward system, reduce emotional eating, and find balance in a world filled with instant gratification. And of course, I'll tie it all back to our Project Weight Loss journey and project management principles—because real, sustainable transformation is all about strategy and balance. If you've ever struggled with cravings, felt stuck in cycles of self-sabotage, or wondered why your body resists change, this episode is for you. Tune in as we uncover the science behind lasting weight loss and the small shifts that make all the difference. Quote of the week: “Balance is not something you find, it's something you create.” – by Jana KingsfordReferences:Caloric Restriction and Metabolic Adaptation: A study published in The American Journal of Clinical Nutrition found that increasing dietary protein from 15% to 30% of energy intake, while keeping carbohydrate intake constant, led to a sustained decrease in ad libitum caloric intake. Dopamine and Eating Behavior: Research in Nature Neuroscience highlighted that dopamine depletion reduces food-related reward activity, indicating that dopamine plays a significant role in eating behavior and energy balance.  Let's go, let's get it done. Get more information at: http://projectweightloss.org

In this week's episode we'll learn about asciminib plus dasatinib in Philadelphia chromosome-positive acute leukemia. In a phase 1 study, combining two tyrosine kinase inhibitors with distinct mechanisms of action had encouraging activity in patients with de novo disease. After that: new research demonstrates that the iron exporter ferroportin contributes to the iron-sensing properties of liver endothelial cells. But is it the primary mediator of systemic iron homeostasis? Finally: anemia in pregnant patients with beta-thalassemia minor. In the third trimester, about one-third of patients have hemoglobin levels of 9 grams per deciliter or lower. This report may help to guide the appropriate diagnosis of anemia while limiting unnecessary testing and interventions. Featured Articles:Asciminib plus dasatinib and prednisone for Philadelphia chromosome–positive acute leukemiaThe hepcidin-ferroportin axis modulates liver endothelial cell BMP expression to influence iron homeostasis in miceβ-Thalassemia minor is associated with high rates of worsening anemia in pregnancy

In this special episode, Forrest focuses on the key lessons from 400 episodes of Being Well, giving you a crash course in personal growth and development. If you're just getting into the show, or are looking for a good episode to share with people who are new to this kind of content, this is a great place to start.  You can watch this episode on YouTube. Key Topics: 0:00: Introduction 1:10: Change is possible, but change is hard 3:00: Focus on what you can control 4:30: The consistency principle 6:05: Punishing ourselves is a losing strategy 7:45: What are you pursuing? 9:30: The negativity bias 11:40: Why you don't have self-worth 13:40: Change the beliefs you have about yourself 17:05: Forming a coherent narrative 19:50: Set reasonable expectations 22:45: The middle path 24:30: Homeostasis and social pressure 26:30: How to get good at anything 27:45: Willpower, and avoiding willpower 28:25: Don't know mind 31:25: The trap of self-awareness 32:35: Risking disappointment 34:10: The function of our bad habits 36:00: Look for those who support you 37:15: Changing our models of relationship 40:00: Authenticity 41:50: Embrace good conflict 44:40: Contempt 46:20: Start by joining 48:40: Experiencing out 49:55: Joining with the defense 51:15: Moving toward to move away 52:40: Learning to trust yourself I am now writing on Substack, check out my work there.  Support the Podcast: We're now on Patreon! If you'd like to support the podcast, follow this link. Sponsors Head to acorns.com/beingwell or download the Acorns app to start saving and investing for your future Zocdoc helps you find expert doctors and medical professionals that specialize in the care you need. Head to zocdoc.com/being and download the Zocdoc app for FREE. Use promo code hanson at the link below to get an exclusive 60% off an annual plan at incogni.com/hanson. Sign up for a one-dollar-per-month trial period at shopify.com/beingwell.  Get 15% off OneSkin with the code BEINGWELL at https://www.oneskin.co/  Transform your health with the ZOE Science & Nutrition podcast. Find it wherever you listen to podcasts. Connect with the show: Subscribe on iTunes Follow Forrest on YouTube Follow us on Instagram Follow Forrest on Instagram Follow Rick on Facebook Follow Forrest on Facebook Visit Forrest's website Learn more about your ad choices. Visit megaphone.fm/adchoices

"El altruismo es la mejor receta para la salud y la longevidad, seguida muy de cerca por la curiosidad" - Carlos López Otín Hoy hablo con Carlos López Otín, es bioquímico, investigador y auto. Su nuevo libro es La Levedad de las Libélulas. Algunos de los temas que tocamos: - Ecuación de la salud y sus componentes. - Silencio, Homeostasis y Hormesis. - Adaptación psicosocial como clave de la salud. - Bryan Johnson y su persecución de la inmortalidad. - Inteligencia artificial y salud. - Y mucho más. Apúntate a mi lista: fitnessrevolucionario.com/lista Como siempre, puedes escuchar también el episodio en iVoox, Spotify  y Apple Podcast.    

Let's imagine a world in which we can be individually identified, manipulated,and managed through the use of frequency-based biomarkers that can easily be identified through our individual vocal frequencies.  What can we achieve/imagine? Frequency is the basis of our universe. We measure it, study it, quantify it and use it to understand ourselves, our environment, our biochemistry and our behaviors. But what if there were more to our origins than a physical body to be nurtured and kept optimally healthy? What if Frequency (the measurement of Vibration and Frequency), the basis of everything, is more than synthetic equations; what if math-based frequencies are organic?  If so, could we be considered math-based life forms? Sharry Edwards is back to talk about Secrets of the Human Biofield: Accelerating Human Healing through Bioacoustics

In this summary episode we discuss how homeostasis is at the core of almost every function in our bodies, including how we train and stay healthy. Learn more about your ad choices. Visit megaphone.fm/adchoices

Thomas Aksnes' journey from overcoming debilitating childhood illnesses to leading global healthcare innovation is a testament to resilience and determination. Following years of ineffective treatments, a life-changing prognosis at 19 propelled him to take charge of his health. Through self-healing, he developed the HEALTH framework—Hippocrates, Education, Assessment, Locating, Targeting, Homeostasis—and founded Health Optimizing clinics. These clinics tackle health challenges at their root by piecing together the intricate "jigsaw puzzle" of the human body.By integrating cutting-edge medical advancements far ahead of conventional timelines, Health Optimizing delivers truly holistic solutions that surpass traditional methods.Dr. Thomas and I dive into…➝ The cutting-edge technology at Health Optimizing clinics➝ Exploring true health and its holistic essence➝ Fevers as a natural and crucial healing mechanism➝ Understanding genetics as predispositions, not root causes➝ Pharmacology and the dangers of symptom suppression or interference➝ And much more!CONNECT WITH DR. THOMAS AKSNESHealth Optimizing: https://www.healthoptimizing.comCONNECT WITH CALInstagram: https://www.instagram.com/cal.callahan/Facebook: https://www.facebook.com/thegreatunlearnYouTube: https://www.youtube.com/c/thegreatunlearn/Website: https://www.thegreatunlearn.comSubscribe to the newsletter: https://www.thegreatunlearn.com/newsletter

Our guest today is Makoto Eyre, cofounder and CEO of Homeostasis, a climate tech startup transforming CO2 into advanced carbon materials like graphite for lithium-ion batteries. Makoto's story exemplifies the power of curiosity, resilience, and the ability to leverage architectural skills to navigate bold career transitions. This episode explores how interdisciplinary thinking, engineering expertise, and a service-driven mindset can lead to impactful innovation. Tune in to hear how Makoto redefined his career to tackle climate challenges and build a sustainable future.Makoto's career journey is a testament to the versatility of architectural skills. After starting his career as a designer and architect-in-training at Seattle's SkB Architects, he transitioned to roles in aerospace engineering at NASA and Blue Origin. Now leading Homeostasis, Makoto is addressing critical global challenges by applying design and engineering principles to climate tech solutions. In his free time, he enjoys bouldering, running, hiking, and tinkering with projects.Highlights:The challenges of traditional architectural practice and the desire to create broader societal impact.The journey from architecture to mechanical engineering and a passion for space exploration.Co-founding Homeostasis, a climate tech startup transforming CO2 into graphite for lithium-ion batteries.Navigating the uncertainties of business development and embracing a service-driven Lessons on resilience, embracing discomfort, and the importance of supportive communitiesGuest Bio:Makoto Eyre is the cofounder and CEO of Homeostasis, a climate tech startup that produces advanced carbon materials, such as graphite for lithium ion batteries, out of CO2. Prior to founding Homeostasis, Makoto worked as a spacecraft configuration & systems engineer at the Advanced Development Program at Blue Origin, as a contracted space architect at NASA's Johnson Space Center, and as a designer & architect in training at SkB Architects in Seattle. Makoto has degrees in architecture and mechanical engineering from the Rhode Island School of Design and the University of Washington, respectively. In his free time, Makoto enjoys bouldering, running, hiking, reading in the park, and building/modding/repairing. ★ Support this podcast on Patreon ★

Have you ever wondered why despite doing all the “right” things, your body still feels like it's stuck? You might have made every effort to detox, eat clean, and even manage your stress, yet your body seems to be working against you. You're not alone in this. It could be that your nervous system is playing a significant role in keeping your body in this cycle. In this episode, we explore the profound connection between nervous system dysregulation, trauma, and chronic illness—particularly in relation to [Insert Keyword]. Together, we'll break down what this means for your healing journey and how understanding this link could be the breakthrough you've been searching for. Our guest today is Alex Howard, a leading expert in trauma education and chronic illness recovery. We dive deep into how trauma can show up in subtle ways and how it leads to a dysregulated nervous system, impacting everything from immune function to your overall ability to heal. If you're ready to uncover the hidden pieces of the puzzle that might be holding you back, you're in the right place. Key Points: What is trauma and how does it impact the nervous system? Alex defines trauma beyond the typical big events we think of. Trauma can be small, repeated experiences from childhood that leave echoes in our nervous system, which later affects our health.  The four stages of trauma impact: ECHO We break down the ECHO model—Events, Context, Homeostasis, and Outcomes—and how each stage influences the nervous system's ability to regulate and heal.  Why nervous system dysregulation can block your recovery If you're stuck despite multiple treatments, it might be because your nervous system is constantly in a fight-or-flight mode. This dysregulation keeps your body from healing as it should.  The importance of being the “captain of your own recovery ship” Taking charge of your healing process is essential. Alex emphasizes that while practitioners offer vital pieces of the puzzle, you are the one who navigates and brings everything together for true healing.  How resetting the nervous system can transform your health Alex shares his RESET framework for nervous system regulation, detailing how each step—Recognize, Examine, Stop, Emotions, and Transform—helps to shift your body out of survival mode.  The link between trauma and immune system function A dysregulated nervous system not only affects your emotional and mental well-being but also leads to an overreactive or underactive immune system, making conditions like [Insert Keyword] even harder to manage.  The journey to healing isn't just about treating physical symptoms; it's about addressing the root causes buried within the nervous system and the echoes of past trauma. As we've discussed, many people stuck in their recovery journey are unknowingly battling a dysregulated nervous system that keeps them in a state of stress and imbalance. By taking control and learning to reset your system, you can unlock a new level of healing and vitality. Remember, the work isn't always easy, but it's worth it. Your nervous system holds the key to not just surviving, but thriving. How to Connect with Dr. Meg: Apply to work 1:1 with Meg: HERE Free Guide: Fatigue to Fabulous: Ultimate Energy Handbook for simple steps and protocols you can start today to skyrocket your energy. You can also follow along on Instagram @drmegmill for daily health tips! Website: www.megmill.com  This content is for educational purposes only and should not be taken as medical advice. Always consult with a healthcare professional before starting any new diet or exercise program.  

This stems from an XSpaces session that I hosted earlier today: https://x.com/GadSaad/status/1852734034721300678 #immigration #capitalism #socialism #freedomofspeech #biology #reality #commonsense #ideology #evidence #progressivism #transgender #secondamendment #firstamendment _______________________________________ If you appreciate my work and would like to support it: https://subscribestar.com/the-saad-truth https://patreon.com/GadSaad https://paypal.me/GadSaad To subscribe to my exclusive content on Twitter, please visit my bio at https://twitter.com/GadSaad _______________________________________ This clip was posted on November 2, 2024 on my YouTube channel as THE SAAD TRUTH_1753: https://youtu.be/iFwM0ZQT0BY _______________________________________ Please visit my website gadsaad.com, and sign up for alerts. If you appreciate my content, click on the "Support My Work" button. I count on my fans to support my efforts. You can donate via Patreon, PayPal, and/or SubscribeStar. _______________________________________ Dr. Gad Saad is a professor, evolutionary behavioral scientist, and author who pioneered the use of evolutionary psychology in marketing and consumer behavior. In addition to his scientific work, Dr. Saad is a leading public intellectual who often writes and speaks about idea pathogens that are destroying logic, science, reason, and common sense.  _______________________________________

In this episode of UNLOCKED, we sit down with Parneet Pal, a Harvard- and Columbia-trained physician and founder of Systematically Well Advisory, Inc., to uncover the roots of holistic well-being and the transformative potential of lifestyle medicine. Parneet shares pivotal “crucible moments” that redefined her view on health, shaped by her journey from traditional medicine to a focus on lifestyle, our biology, and planetary health. Through fascinating discussions on resilience, well-being, and leadership in the workplace, she brings actionable insights to balance growth and repair within our bodies and workplaces. Join us as we explore how each choice we make is a step toward building a thriving and healthy life—one that is deeply regenerative for ourselves, our communities, and the planet.Key Moments:00:02:01 – Parneet's Journey: Parneet shares her shift from traditional medicine to lifestyle wellness.00:08:01 – True Health Defined: Parneet expands on holistic health and the "exposome."00:15:01 – Homeostasis & Energy: Discussing how cellular energy signals well-being.00:21:01 – Lifestyle Medicine Basics: Key lifestyle factors for balancing health.00:28:01 – Nature's Model: Insights from nature on sustainable well-being.00:38:01 – Workplace Well-being: Parneet on burnout and productivity in businesses.00:46:01 – Leadership & Change: How leaders can support team well-being.00:52:01 – Systematically Well Programs: Overview of Parneet's wellness programs for teams.00:56:01 – Closing Reflection: Parneet's favorite quote on creating a life that fosters life.About Parneet:Parneet Pal, MBBS, MS is a Harvard- and Columbia-trained physician-educator who teaches skills and communicates ideas that advance personal, workplace and planetary health.As the Founder of Systematically Well Advisory Inc., she works with business teams and global organizations to address leadership, performance, wellbeing and sustainability using evidence-based strategies from lifestyle medicine, neuroscience, behavioral science and psychology.Previously, she designed preventive wellbeing programs for Executive Health (including at the University of California, San Francisco), and led faculty, curriculum and content development as the Chief Science Officer of a health start-up scaling corporate mental wellbeing.Parneet speaks about the connections between Health, Leadership and Sustainability at global conferences and guest lectures at several universities. She has been a TEDMED scholar, Harvard Business Review contributor and has been featured on the cover of Mindful magazine.Connect with Parneet:Website: www.parneetpal.comLinkedIn: www.linkedin.com/in/parneetpalInstagram: @pal.parneetConnect with Owl & Key:Website: www.owlandkey.coInstagram: www.instagram.com/owl_and_key/Everything Else: linktr.ee/owlandkey

Ahmed and Eric discuss the concept of homeostasis and negative feedback loops, while looking in depth specifically at calcium homeostasis. Want to learn more? Shoot us a text at 415-855-4435 or email us at podcast@jackwestin.com!

“...what matters most with healing is your body's ability to adapt, that your nervous system function is high enough that you can respond to whatever stressor it is…” Join Dr. Nick Wilson and special guest Leah Wilson as they discuss cold plunges, red light therapy, and other biohacks and whether they are fitting for your life and health. They dive into: What are biohacks and what counts as a biohack? The effects of chronic biohacking Homeostasis and hormesis Becoming more adaptable How to discover intentions and principles for becoming adaptable Sign up for our next LIVE event here: EXIT THE STORM, a live seminar in Indianapolis, IN, on Saturday, November 2nd. Like this episode? Be sure to subscribe to automatic downloads and follow Dr. Nick Wilson on Instagram to always be notified of upcoming episodes. To follow Dr. Wilson on Instagram, click here. To make an appointment at Restructured Chiropractic in Indianapolis, IN, click here.

In this episode, Dr. Jessica Steier and Dr. Sarah Scheinman investigate the widespread myth that sugar causes ADHD and hyperactivity. The scientists trace the origins of this belief, including the influential Feingold diet, and examine scientific studies that challenge the purported link between sugar and hyperactive behavior. They explore sugar's biological effects on the brain, discuss the concept of addiction in relation to sugar, and consider the health consequences of excessive sugar consumption. Dr. Steier and Dr. Scheinman provide a balanced perspective on sugar intake, emphasizing the importance of moderation and informed dietary choices. This episode offers listeners valuable insights into the complex relationship between nutrition and behavior, debunking common misconceptions about sugar's impact on hyperactivity and ADHD. All our sources from this episode are available at: https://www.unbiasedscipod.com/episodes/ (00:00) Introduction  (03:30) Understanding Sugar and Its Impact (09:04) The Myth of Sugar and Hyperactivity (12:31) The Feingold Diet and Its Legacy (14:01) Meta-Analysis Findings on Sugar and Behavior (15:50) Expectation Effect and Environmental Factors (16:54) The Brain's Reward System and Sugar (19:54) Sugar Addiction: Myth or Reality? (21:49) Health Implications of Excess Sugar Intake (24:03) Homeostasis and Brain Health (26:50) Cerebral Small Vessel Disease and Sugar (30:45) The Balance of Sugar in Diet (33:49) Final Thoughts: Conclusion and Key Takeaways Interested in advertising with us? Please reach out to advertising@airwavemedia.com, with “Unbiased Science” in the subject line. PLEASE NOTE: The discussion and information provided in this podcast are for general educational, scientific, and informational purposes only and are not intended as, and should not be treated as, medical or other professional advice for any particular individual or individuals. Every person and medical issue is different, and diagnosis and treatment requires consideration of specific facts often unique to the individual. As such, the information contained in this podcast should not be used as a substitute for consultation with and/or treatment by a doctor or other medical professional. If you are experiencing any medical issue or have any medical concern, you should consult with a doctor or other medical professional. Further, due to the inherent limitations of a podcast such as this as well as ongoing scientific developments, we do not guarantee the completeness or accuracy of the information or analysis provided in this podcast, although, of course we always endeavor to provide comprehensive information and analysis. In no event may Unbiased Science or any of the participants in this podcast be held liable to the listener or anyone else for any decision allegedly made or action allegedly taken or not taken allegedly in reliance on the discussion or information in this podcast or for any damages allegedly resulting from such reliance. The information provided herein do not represent the views of our employers. Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode of the Dr. Tyna Show, I engage in an important conversation with peptide and bioregulator expert Nathalie Niddam, a discussion many of you have requested. We explore the intricate landscape of peptides, examining FDA regulations and the significant regenerative properties of bioregulators. Nathalie provides valuable insights into how these therapies can effectively modulate bodily functions and restore homeostasis. This episode is a must-listen for anyone seeking to deepen their understanding of advanced therapeutic peptide options. Ozempic Uncovered FREE 4 Part Video Series  Check Out Nathalie Niddam Website Instagram Podcast On This Episode We Cover:  00:00:00 - Introduction  00:04:22 - Nathalie's backstory  00:08:23 - FDA regulations and peptides   00:10:38 - Bioregulators  00:14:28 - Regenerative properties  00:18:44 - The impact of bioregulators 00:26:07 - Weston Price and Pottenger's Cats 00:28:01 - Bioregulators protocols  00:30:57 - Short chain peptides  00:37:35 - Modulating and tonifying  00:40:46 - Getting back to homeostasis  00:44:01 - Pulsing bioregulators  00:46:45 - Peptides and conventional medicine  00:50:21 - Homeostasis vs optimization  00:55:09 - The risks and rewards of peptides  01:00:22 - Where to find Nathalie    Ozempic Uncovered Podcast Series: EP 106: Ozempic Done Right Part 1 | Solo Episode EP 107: Ozempic Done Right Part 2 | Solo Episode EP. 109: Ozempic Done Right Part 3 | Solo Episode Ep. 116: Berberine: NOT Nature's Ozempic | Quick & Dirty EP. 118: My GLP-1 Experience | Quick & Dirty EP. 129: Ozempic Done Right Part 4: Sustained Weight Loss | Solo Episode EP. 132: Ozempic Done Right Part 5: Osteoarthritis + GLP1 Agonists | Solo Episode EP. 136: Ozempic Does NOT Cause Muscle Loss | Solo Episode Sponsored By:  SiPhox Health Visit siphoxhealth.com/drtyna to get 20% off your first at-home blood test. Maui Nui Use code DRTYNA for 20% off at mauinuivenison.com Manukora Head to MANUKORA.com/DRTYNA to get $25 off the Starter Kit PaleoValley For 15% off go to http://paleovalley.com/drtyna Timeline Nutrition Go to timelinenutrition.com/DRTYNA and use code DRTYNA for 10% off LMNT Get your free Sample Pack with any LMNT purchase at drinkLMNT.com/drtyna Disclaimer: Information provided in this podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem. Information provided in this blog/podcast and the use of any products or services related to this podcast by you does not create a doctor-patient relationship between you and Dr. Tyna Moore. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.

In today's episode of the "Fasting for Life" podcast, we discussed the impacts of fasting on cholesterol, highlighting studies that show how intermittent fasting, even with higher carbohydrate intake, can significantly improve lipid profiles by reducing LDL, triglycerides, and increasing HDL. We emphasized that these benefits can occur without significant weight loss and called for a global re-evaluation of cholesterol's role and management. They encouraged listeners to take immediate, actionable steps to incorporate fasting into their routines for better health outcomes. FREE RESOURCE - DOWNLOAD THE NEW  BLUEPRINT TO FASTING FOR FAT LOSS! Learn how to RAMP UP into longer fasting windows! Gain insights into the non-weight loss benefits of fasting! Personalize your own fasting schedule and consistent FAT LOSS results! Get answers to what breaks a fast, how to break a fast, and tips and tricks to accelerate your fasting wins! THE BLUEPRINT TO FASTING FOR FAT LOSS DOWNLOAD Link to Berberine mentioned in this episode: https://us.fullscript.com/plans/ffl-berberine DOWNLOAD THE FASTING TRANSFORMATION JOURNAL HERE! Get your FREE BOX OF LMNT hydration support for the perfect electrolyte balance for your fasting lifestyle with your first purchase here! Get 30% off a Keto-Mojo blood glucose and ketone monitor (discount shown at checkout)! Click here! Let's continue the conversation. Click the link below to JOIN the Fasting For Life Community, a group of like-minded, new, and experienced fasters! The first two rules of fasting need not apply! Fasting For Life Community - Join HERE New to the podcast and wondering where to start? Head to the website and download our  Fast Start Guide, 6 simple steps to put One Meal a Day Fasting (OMAD) into practice! Get our NEW sleep guide here! SLEEP GUIDE DIRECT DOWNLOAD If you enjoy the podcast, would you please tap on the stars below and consider leaving a short review on Apple Podcasts/iTunes? It takes less than 60 seconds, and it helps bring you the best original content each week. We also enjoy reading them! Research Links: https://www.sciencedirect.com/science/article/abs/pii/S2405457718300020 https://pubmed.ncbi.nlm.nih.gov/37297894/ https://pubmed.ncbi.nlm.nih.gov/38276308/#:~:text=Baseline%20LDL%2DC%20was%20384,be%20seen%20as%20health%20advice

It's a stressful world we live in, especially for entrepreneurs and business people. The constant go-go-go nature of work can leave us desperate for rest and recovery. But are you resting efficiently? Is your relaxation truly restorative and rejuvenating, or do you find yourself stuck in fight-or-flight mode even during downtime? In this week's episode, Dr. Jay explores the concept of restorative relaxation through vibroacoustic therapy with leading expert Craig Goldberg, President and Co-Founder of inHarmony Interactive. Craig Goldberg is a Certified Vibroacoustic Therapy Practitioner and Essential Oils Educator dedicated to helping others optimize their health and performance. With a passion for science, technology, and wellness, Craig believes in the power of small, daily changes to help individuals feel better each day. He co-founded inHarmony Interactive in 2020 to bring Vibro-Tactile Stimulation and Vibro-Acoustic Technology to the market, using these products to induce a deep meditative state. During the episode, Dr. Jay and Craig discuss what it means to be a relaxation expert, how vibroacoustic therapy works, our bodies' need for homeostasis, chakras, the power of rest, and much more. Learn more about inHarmony and all their available products. Follow Craig: Instagram Chapters: 00:00 Cold Open 00:48 Introduction 03:33 Success Snack 05:01 Introduction 06:30 Relaxation Expert 09:14 Craig's Journey Into Vibroacoustic Therapy 15:05 The Need for Homeostasis 19:55 Making the Time is Worth It 25:52 Intentional Choices for Meditation 29:51 Chakras 34:33 Timeframes for Meditations 37:20 Where Beginners Should Start 49:14 How to Listen 52:01 Craig's Products Join Dr. Jay's 3 Day Money Mindset Challenge for FREE and change your money story for good! Find all things Triple P Life by visiting the website. Follow Dr. Jay: Facebook | LinkedIn | YouTube Get Dr. Jay's Book: Change Your Mind Change Your Destiny Find all the nutrition and supplement products Triple P Nutrition has to offer here.

Wellness + Wisdom | Episode 636 What is the secret ingredient to aging gracefully? Alessandra Zonari, Scientist and Co-Founder of OneSkin, joins Josh Trent on the Wellness + Wisdom Podcast, episode 636, to unpack how skin health impacts your health and longevity, why senescent cells are behind visible aging, and how the revolutionary peptide developed by OneSkin helps your skin thrive. "You age better when you are feeling good about yourself. Aging is a malleable process. It's more about our choices and lifestyle, and we can bring science to help us to age better." - Alessandra Zonari 15% Off OneSkin 15% OFF WITH CODE "JOSH15" All OneSkin Topical Supplements are formulated with OS-01, the first ingredient scientifically proven to reverse skin's biological age at the molecular level. OneSkin team screened over 900 peptides to develop OS-01: The first peptide proved to reverse skin's biological age by reducing senescent cell accumulation. Their proprietary technology, including the rigorous in-house R&D process and the OS-01 peptide, is supported by 4 peer-reviewed scientific publications and 14 patent publications, with more coming. In This Episode, Alessandra Zonari Uncovers: [01:30] Skin Health + Longevity Alessandra Zonari OneSkin - 15% off with code "JOSH15" Wellness Mama: 644 Secrets to Longevity and Healthy Skin with Alessandra Zonari of OneSkin Why Alessandra used to be scared of aging and getting old. What drove her to study biology and stem cells. How she started researching skin in San Francisco to help reverse biological aging. [08:30] Skin Thinning + Inflammation Every step of your life leads you to the thing you're meant to do. The epidermis is the largest organ in the human body. The layers of skin that protect our internal body. How skin can contribute to inflammation. Why our skin gets fragile and thin as we age. [14:50] Senescent Cells Make You Age Faster The five layers of the epidermis. Why senescent cells start causing inflammation as we get older. How UV light and diet affect senescent cells. A healthy lifestyle is crucial for healthy skin. How OneSkin formulated a peptide product that can help reduce senescent cells in your skin. [20:40] Peptides for The Skin How peptides support the skin with amino acids. Josh's and Lauren's experience using OneSkin products. OneSkin's skincare is validated by scientific research. Why they're not a beauty company but a wellness company. [27:35] Skin Health Begins on The Inside The inner and outer care we need to feel and be well. Many skin products are toxic. How the skin reacts to the food we eat. Our skin tells us what's going on on the inside. [32:50] Measure Your Biological Age Taking care of our skin can be a spiritual journey. The body is telling us a lot of information through our skin. 626 Clockwize: The Missing Link Between Biological Age + Birthing Children (Fertility is Not What You Think) | Dr. Katherine Zagone 581 Healthspan Revolution: Game-Changing Biomarker Blood Testing (SiPhox) | Michael Dubrovsky Is it possible to measure the biological age of the skin? [36:40] The Skin Microbiome OS-01 FACE: Clinically Validated to Support Your Skin's Microbiome Why the skin microbiome needs to be balanced in order for our skin to look healthy. How OS-01 positively impacts the skin microbiome. Why our skin gets drier as we get older. There is a million-dollar research behind OneSkin. Why they wanted to make the skin products affordable to most people. [42:45] Aging Gracefully How society creates false narratives around aging. Why OneSkin is not anti-aging but pro-longevity. It's important to feel good as we age, instead of trying to go against it. How we have old age associated with disabilities. What we can learn from Blue Zones. [46:50] Exercise + Thoughts Impact Your Skin How mothers can take care of themselves to age gracefully. Physical exercise changes how we age and how we feel mentally and emotionally. Why Alessandra wouldn't want to be 20 again. If we change the way we think, we can change how we age. [50:10] Science + Feminine Energy Why the feedback from customers fuels Alessandra to keep doing more research and developing the company. What she loves about science. How the world is accepting the expression of feminine energy. Why OneSkin didn't plan to launch their own product. [57:15] Wholeness Comes from Wellness Why OneSkin keeps conducting research after the product has been launched. We can't have wholeness without wellness. We need to think of our wellness in the long run. Leave Wellness + Wisdom a Review on Apple Podcasts Power Quotes From The Show OneSkin Is Pro-Longevity "At OneSkin, we are not anti-aging, we are pro-longevity. What we want to bring to people's life is the empowerment on aging and helping them get a skin that's strong to navigate the path of aging." - Alessandra Zonari Get Rid of Senescent Cells "What we did at OneSkin was research a new molecule that could reduce the senescent cells in the skin that secreting inflammation. When we are young, our body removes the cells and the tissue restores the homeostasis. But as we age, some of the cells don't die. And that constant release of inflammation start deteriorating the healthy environment around that cell." - Alessandra Zonari The Skin Protects Your Organs "Our skin is protecting all our organs internally from all the stressors in the environment. It's a very important organ that keeps the homeostasis of our body." - Alessandra Zonari Links From Today's Show  Alessandra Zonari OneSkin - 15% off with code "JOSH15" Wellness Mama: 644 Secrets to Longevity and Healthy Skin with Alessandra Zonari of OneSkin 626 Clockwize: The Missing Link Between Biological Age + Birthing Children (Fertility is Not What You Think) | Dr. Katherine Zagone 581 Healthspan Revolution: Game-Changing Biomarker Blood Testing (SiPhox) | Michael Dubrovsky OS-01 FACE: Clinically Validated to Support Your Skin's Microbiome New Publication: Microbiome clinical study New Publication: Face Clinical Study manuscript FastCompany Award for OneSkin - Most Innovative Companies list   Josh's Trusted Products | Up To 40% Off Shop All Products Biohacking BREATHE - 33% off with the code “PODCAST33”