The Human Guinea Pig Project

In this episode of the podcast I discuss the potential applications of ChatGPT in healthcare with Dr Harvey Castro. Dr Castro is a physician, healthcare consultant and author, on a mission to increase awareness of digital health and implement new changes in healthcare. He has just released a new book, titled 'ChatGPT and Healthcare: The Key To The New Future of Medicine'. He is passionate about helping others to succeed in the healthcare and digital health industries and so I was grateful to have him on the podcast.What is ChatGPT and how might it transform healthcare? ChatGPT is a powerful language generation model that has the ability to understand and respond to natural language input. In the field of healthcare, ChatGPT has the potential to revolutionize the way patients interact with their medical providers and access information about their health.If you would like to learn more about Dr Castro and his work please see the links below:'ChatGPT and Healthcare: The Key To The New Future of Medicine' https://www.amazon.co.uk/ChatGPT-Healthcare-Key-Future-Medicine-ebook/dp/B0BS1YYNL9 LinkedIn profile linkedin.com/in/harveycastromd Websites • harveycastromd.info (Company) • successreinvention.com (Blog) • doximity.com/cv/harveycastromd (Other) https://wikitia.com/wiki/Dr._Harvey_Castro Twitter @HarveycastroMD Facebook https://www.facebook.com/HarveyCastroMD Instagram https://www.instagram.com/harveycastromd/ Youtube https://www.youtube.com/harveycastromd

In this episode I raise awareness of the cancer metabolism study that I will be working on alongside Isabella Cooper at the University of Westminster. This is a self-funded study that requires support from a number of sources. Establishing key partnerships and engaging with an audience who are equally as passionate about this subject is vital to our success. To find out more about the study and to see how you can contribute, see the following link:https://beatbraincancer.co.ukFor more information, you can find our most recent interview about the study here:https://www.youtube.com/watch?v=EK6KGd7K_J0&t=1065s

Mary Biles is a medical cannabis writer and educator. She has written extensively on the subject, authoring a book titled ‘The CBD Book: The Essential Guide to CBD oil, and hosts the podcast series Cannabis Voices.In this episode we will be covering the subject of cannabis and cannabis based medicines.Mary Biles can be found at:https://www.marybiles.comCannabis VoicesShow notes:Cancard- A medical ID card, recognised by the police, indicating to any third-party that you are consuming cannabis for medical reasons.https://cancard.co.ukProjectCBD-A California based not for profit with an established history covering the subject with fact checked, evidence based information on a variety of conditionshttps://www.projectcbd.orgProject Twenty21- The largest observational medical cannabis study in the UK, gathering data on the efficacy of cannabis-based medicines for a wide range of conditions. https://www.drugscience.org.uk/twenty21/Sapphire ClinicsThe first UK medical cannabis clinic registered by the Care Quality Commision.https://www.sapphireclinics.com/about/

This episode represents the final part of a series of conversations regarding the safety of gadolinium based contrast agents. Here we discuss who is most at risk for retaining gadolinium and how we can effectively get it out of the body using chelation therapy. I am joined by:Dr Richard Semelka - Dr Richard Semelka is a leading expert in Radiology for body MRI and gadolinium toxicity.He has written over 370 peer-reviewed papers and 16 text-books. and is the first doctor to publish on the entity of gadolinium deposition disease.Dr semelka offers clinical medical consultations for individuals experiencing gadolinium toxicity and in this discussion we will be observing practically how this is treated in the clinic.Kate Skardon - A patient advocate, continuing chelation therapy to remove gadolinium from the body following devastating consequences. Her story can be found here:   https://www.youtube.com/watch?v=4aozx...https://www.youtube.com/watch?v=1RvHA...Debbie Lambert- A patient advocate who seeks to raise awareness about Gadolinium Deposition Disease through various mediums, including the links below:https://m.facebook.com/pg/livingwithg...https://twitter.com/lambertdebbShow notes:HOPO Therapeutics- oral chelationhttp://www.hopotx.com/science/SAGE- Symptoms Associated with Gadolinium Exposurehttps://pubs.rsna.org/doi/abs/10.1148/radiol.2021211349

Dr. Wagner is a clinical nephrologist. He is the Director of the Kidney Institute of New Mexico as well as being the acting Associate Chief of Research and Renal Section Chief for the VA in Albuquerque. This is the second time Dr. Wagner has been on the podcast with his research team. In this episode we re-examine the mechanisms behind gadolinium retention and receive updates on new discoveries.To fund Dr. Wagner's work you can donate to the Kidney Institute of New Mexico athttps://www.unmfund.org/fund/unm-kidney-institute-of-new-mexico/Links:Reveal Pharmaceuticals, Gadolinium-free MRI contrast agents products.http://www.revealpharma.comThe FDA adverse event reporting systemhttps://open.fda.gov/data/faers/Gadolinium-Based Contrast Agent Use, Their Safety, and Practice Evolutionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8378745/

Dr. Elena Gross is a neuroscientist with a PhD in clinical research (specifically Ketosis in migraine prevention). She is also the CEO & founder of KetoSwiss. KetoSwiss develops and markets high quality exogenous ketone body therapeutics for use in disease prevention and treatment of specifically neurological diseases.KetoSwiss-  https://www.keto.swissYou can find Dr. Elena Gross on:Twitter - https://twitter.com/drelenagrossInstagram - https://www.instagram.com/drelenagross/Youtube - https://www.youtube.com/c/DrElenaGross

Gemma Herbertson is the creator of the Neuro Fronteirs website http://neurofrontiers.org and the Diets for Epilepsy Facebook group. In this episode we talk about the upcoming Neuro Frontier Summit, holistic approaches to managing epilepsy and her son Eddy's recovery following a brain tumour diagnosis as a baby. Eddy greatly benefited from neuroplastic therapies, a personalised diet and hyperbaric oxygen therapy under the guidance of experienced practitioners. Gemma seeks to raise awareness of these approaches through the website, related events and discussion groups. Show notes: Education: The Neuro Frontier Summit - https://www.neurofrontiers.org/summit/ANI Diet  https://www.neurofrontiers.org/anti-n...Exchange Breathing Method  https://www.neurofrontiers.org/natura...Epilepsy  https://www.neurofrontiers.org/condit...Neuroplasticity Therapies  https://www.neurofrontiers.org/neurop...Practitioner Locator  https://www.neurofrontiers.org/natura...

In this episode we discuss how the Care Oncology Clinic supports cancer patients with integrating repurposed drugs into their treatment regime. The clinic aims to complement standard treatments with repurposed drugs under the guidance of expert clinicians in order to deliver a safe, evidence based approach. Data is collected in order to improve outcomes for patients with various forms of cancer.We discuss the drug selection process, how safety and efficacy is monitored, what are the findings so far and future directions of the clinic.Resources mentioned in discussion:The Frontiers paper from 2019 which takes in research methods and strategy, and discusses some of the challenges associated with generating good quality real world evidence. It also present preliminary outcomes data in our cohort of 95 GBM patients:https://www.frontiersin.org/articles/10.3389/fphar.2019.00681/fullThe best place for patients to find white papers aggregating a sample of relevant research literature on the COC Protocol meds in the context of different types of disease is on the US sister company website under the tab “COC – Select Cancer Types”. For example, here is the link to one on Ovarian cancer: https://careoncology.com/the-coc-protocol-in-ovarian-cancer/

In this episode I chat to Dr. Stuart Farrimond. Dr Farrimond is a science and medical writer, presenter and educator. He is also a trained medical doctor and qualified teacher. Dr Farrimond has written a number of international best selling books including ‘The Science of Cooking, Science of Spice, and most recently ‘The Science of Life', in which he answers 219 key questions on how to live your best life. He has made numerous TV and radio appearances as well as having produced several articles in various publications.In this episode of the podcast we discuss his experiences as a brain cancer survivor with a medical background and what influence this has had on his life.

8-year-old Deliah Sitorius had been fighting a rare brain cancer for almost a year with chemotherapy . Unfortunately this was unsuccessful and she stopped treatment immediately. Deliah was given hope after her mother discovered the tumour has a rare mutation often seen in lung cancer. Since applying a more targeted, personalised approach using a drug called Lorlatinib the tumour has been shrinking.Loratinib is a third generation ALK ROS1 tyosine kinase inhibitor, specifically designed to overcome known ALK resistance mutations. It is able to penetrate the blood brain barrier and more recently we have seen paediatric brain cancer patients who are responding very well to the drug.

In this episode, recorded just before the New Year, I discuss recent news in brain cancer research. This includes:How the drug loperamide (brand name Imodium), induces cell death in glioblastoma cell lines and if this could have promise for real, human applications. Metabolic reprogramming via inhibition of a key cancer metabolite- D-2-Hydroxyglutarate (D-2-HG).Developments of liquid biopsies for glioma. 

This episode features long term GBM survivor and OurBrainBank board member Meredith Moore. We discuss the benefits of empowering patients to make informed choices about their treatment and how this has helped her to survive for 15 years and counting following a diagnosis of GBM in 2005.A large part of our conversation highlights patient advocacy and Meredith's involvement with OurBrainBank. OurBrainBank is an innovative, patient-led movement designed to move glioblastoma from terminal to treatable, powered by patients.

Isabella Cooper is a PhD researcher in Ketogenic Science and Hyperinsulinemia at the University of Westminster. In this episode we discuss her research on this and related topics, with a specific focus on women. https://www.researchgate.net/profile/Isabella_Cooper2

Mithu Storoni MD PhD is an author, physician, and researcher. She has undertaken research in Neuro-ophthalmology and Perceptual Neuroscience at Cambridge, in London and at Harvard Medical School. Her book 'Stress Proof' seeks to provide practical, evidence based solutions to better manage the unique psychological challenges that modern life presents.In this episode of the podcast we discuss how to manage stress and anxiety in the age of Covid-19.

Marty Kendall is a civil engineer with a strong passion for nutrition and founder of Optimising Nutrition https://optimisingnutrition.com. From the experiences of helping his wife manage Type 1 diabetes and extensive research into optimal nutrition science, Marty has devised a number of programs and recipe books to help others achieve their nutrition goals with maximum micronutrient density, whatever form of diet they may choose to adopt. The main aim of these programs is to allow individuals to achieve stable blood sugar control with maximum nourishment.In this episode I discuss Marty's objective approaches to his Nutrient Optimisation programs as well as his new set of recipe books, available to download from the Optimising Nutrition website.

Dr. Akbar Khan is the founder and Medical Director of Medicor Cancer Centres, a cancer clinic which allows patients to receive optimised care by integrating conventional, naturopathic and off-label therapies. 

Tristan founded Primal Edge Health with his wife Jessica in 2014 as a means to explore the cutting edge of holistic lifestyle optimisation. They share knowledge on animal-based nutrition, the ketogenic and carnivore diets, whole unrefined ancestral foods, regenerative agriculture, and homesteading as part of their mission to build healthy bodies, homes, families and communities. You can follow Primal Edge Health on Youtube, Instagram, Twitter and Facebook where they share the latest ketogenic recipes, research, and critique big business, anti-health propaganda.: Youtube- https://www.youtube.com/primaledgehealth Instagram- https://www.instagram.com/primaledgeh... Twitter- https://twitter.com/TristanHaggard Facebook- https://www.facebook.com/PrimalEdgeHe...

Nathan Delack is a 7-time EMMY-award-winning television news photojournalist.In this episode I interview Nathan on his upcoming documentary film about the McCullom Lake cancer cluster, chronicling the town's search for answers and their fight for justice.LINKS:http://www.McCullomlake.nethttp://www.facebook.com/McCullomLakehttp://www.Twtitter.com/McCullomLakeBackground:In 2014, residents of McCullom Lake, Illinois, settled an eight-year-old lawsuit in which they claimed exposure to vinyl chloride and other volatile organic compounds from a nearby Dow Chemical plant had caused a brain cancer cluster in the area. The original lawsuits also named the neighbouring Modine Manufacturing plant, alleging that its contribution of trichloroethylene to the plume made it culpable for illnesses. Modine settled with the plaintiffs in 2008 for undisclosed amounts.The village of McCullom lake has a population of just over 1,000 residents. A brain cancer cluster of 33 brain tumours was reported at the time, with many more people thought to be affected following further investigation.

Dr. Wagner is a clinical nephrologist. He is the Director of the Kidney Institute of New Mexico as well as being the acting Associate Chief of Research and Renal Section Chief for the VA in Albuquerque. In this episode we discuss recent evidence urging caution over the use of gadolinium based contrast agents.To fund Dr. Wagner's work you can donate to the Kidney Institute of New Mexico athttps://www.unmfund.org/fund/unm-kidn...Links:Reveal Pharmaceuticals, Gadolinium-free MRI contrast agents products.http://www.revealpharma.comPeter Caravan PhD. Director, Institute for Innovation in Imaging Massachusetts and Associate Professor of Radiology at Harvard Medical School.Twitter- @PeterCaravanThe FDA adverse event reporting systemhttps://open.fda.gov/data/faers/Gadolinium-based contrast agents: why nephrologists need to be concernedhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416778/

Pablo Kelly is a long term survivor of a glioblastoma multiforme brain tumour. Here we discuss how and why he decided to attempt to manage his disease with the aid of metabolic therapies.

Episode 1: Jessica Morris.Jessica Morris is a strategic communications consultant and founder of OurBrainbank, a ground-breaking movement designed by, with and for people with glioblastoma (GBM), after being diagnosed with the disease herself in January 2016. She is a vocal patient advocate for exploring new options to treat GBM and has recently taken part in a phase 1 trial using the herpes simplex virus to treat recurrence of her disease. In this episode we discuss virotherapy, clinical trials, and how the Ourbrainbank initiative can benefit patients.Time-Stamps:2.08 GBM diagnosis3.09 Aim following diagnosis. Staying alive and enjoying life, coming up to 4thyear.3.38 Background, insights on GBM and pathology.5.05 Strategy to tackle the disease5.45 Adding Nivolamab (Opdivo)- a checkpoint inhibitor form of immunotherapy alongside the ketogenic diet, intermittent fasting, and the Optune device.6.50 Interaction between the Optune device and immunotherapy7.09 Recurrence and surgery7.50 Plan of action following recurrence8.23 Clinical trials in the U.S.9.09 Being part of an ‘N of 1' clinical trial.10.37 Ourbrainbank10.52 Virotherapy- Being a candidate for the polio virus trial for GBM and how it works12.16 Insights on the clinical trial framework and eligibility for the herpes virus trial12.35 Being a part of the herpes virus trial (as a phase 1 trial) and how it works13.34 Herpes virus trial- Experiences having the procedure15.23 Herpes virus trial- How did it feel when the adapted virus was being administered via the catheter?15.49 Symptoms of trial- indication of how long spells of fatigue are expected17.01 What was the exclusion criteria for the herpes trial? The clinical trial model and the Karnofsky score19.43 Polio and herpes virus vaccinations. Vaccination before virotherapy trials?21.07 Personalised medicine vs one size fits all virotherapy trials22.18 Were you given any guidelines or recommendation on lifestyle factors that could compliment the treatment and further boost your immune system? Ketogenic diet and intermittent fasting. Oncologist response.24.30 Ourbrainbank- why was it set up? A more patient centred approach with psychological support and second opinions.25.30 advocating for second opinions26.26 How do you feel about patient awareness and access of clinical trials28.30 Ourbrainbank and clinical trials29.11 Ourbrainbank event in London, repurposed drugs and experimental treatments away from the standard of care. Compassionate use programmes.30.12 Ourbrainbank launch and app33.03 more information about the app.34.37 How do you see the future in terms of your endeavours and what do you see the most potential in?37.54 Have you heard about any other patient experiences on the herpes virus trial?39.42 MRI monitoring following virotherapy- effects of initial inflammatory response on tumour?41.28 Perspectives on having a ‘terminal' diagnosis.- views on cancer terminology42.50 How do you deal with apprehension and the mental side of dealing with the disease?45.55 App.- Looking at symptoms. Reactions from clinicians?50.33 Are you able to compliment these forms of documenting symptoms with wearables? Surprising highlight 53.0353.03 Availability of the app and how to find it- share 53.4354.48 Final words and advice to other patients