Podcasts about Glioblastoma

Broadcast from KSQD, Santa Cruz on 5-22-2025: Dr. Dawn explores groundbreaking cancer research using high-throughput "digital twin" analysis to reverse colon cancer cells back to normal states, identifying three master molecular switches that can induce normal cell differentiation without killing the cancer cells, thus avoiding traditional chemotherapy side effects. She discusses remarkable results from Memorial Sloan Kettering showing 80% of patients with mismatch repair deficient tumors, including all 49 rectal cancer patients, saw complete tumor disappearance after six months of dostarlimab immunotherapy, with no recurrence at five years and minimal side effects. The program covers innovative CRISPR applications, including targeting previously "undruggable" cancer mutations like KRAS and BRAF by selectively degrading mutant RNA messages while preserving healthy genes, offering unprecedented precision in cancer treatment. Dr. Dawn explains a clever immunotherapy approach that disguises tumors as pig organs using Newcastle disease virus carrying alpha-gal enzyme, tricking the immune system into mounting fierce attacks against cancer cells, showing promising results in both monkey and human trials. She describes fascinating research using cryoshocked tumor cells as Trojan horses, where liquid nitrogen-treated cancer cells carrying CRISPR gene editing tools directly seek out tumors, offering superior targeting compared to injecting CRISPR. The show reveals how cancers create protective acid walls around themselves to repel immune cells, with individual cancer cells pumping lactic acid away from the tumor center to form pH 5.3 barriers that kill attacking CD8 T cells within hours. Dr. Dawn discusses breakthrough mRNA cancer vaccines for glioblastoma using patients' own tumor cells, showing rapid immune system activation within 48 hours and extending survival in both dogs and humans with this aggressive brain cancer. She explores the "flower code" mechanism where cancer cells gaslight healthy cells through epigenetic manipulation, expressing dominant "flower win" codes to overpower normal cells expressing "flower lose" codes in biological turf wars. The program addresses systemic problems in cancer classification, explaining how organ-based categorization delays access to effective treatments, with patients waiting years for drugs that could help based on molecular profiles rather than tumor location. Dr. Dawn concludes by highlighting medical discrimination against people with Duffy null phenotype, primarily affecting African Americans, whose naturally lower neutrophil counts lead to reduced chemotherapy doses and excluded clinical trial participation despite no increased infection risk.

Scientists have engineered small, targeted proteins that can penetrate brain cancer cells and prevent them from invading healthy tissue, offering a promising new approach to treating glioblastoma multiforme (GBM), one of the deadliest forms of brain cancer. This strategy was developed by researchers at the University of Nevada, Reno, and published recently in Oncotarget. The Challenge of Treating Glioblastoma Multiforme Glioblastoma is an aggressive and fast-growing brain tumor that infiltrates healthy brain tissue, making complete surgical removal nearly impossible. Standard treatments like chemotherapy and radiation can slow its growth but rarely prevent it from returning. One major reason for this invasiveness is a group of enzymes known as matrix metalloproteinases (MMPs), which break down surrounding tissue to allow cancer cells to spread. Among these, MMP-9 plays a particularly important role in driving tumor progression and resisting existing therapies. Attempts to block MMPs using small-molecule drugs have failed in clinical trials due to problems like poor selectivity and harmful side effects. Researchers have been searching for safer, more targeted methods to interfere with these enzymes and limit glioblastoma's spread. The Study: Engineered Proteins to Inhibit Tumor Invasion In the study called “Effect of TIMPs and their minimally engineered variants in blocking invasion and migration of brain cancer cells,” researchers Elham Taheri and Maryam Raeeszadeh-Sarmazdeh investigated tissue inhibitors of metalloproteinases (TIMPs), which are natural blockers of MMPs, and their engineered modified versions made to work better. Specifically, the team studied TIMP-1, TIMP-3, along with two engineered molecules, mTC1 and mTC3, in laboratory cell models of GBM. Full blog - https://www.oncotarget.org/2025/05/21/engineered-proteins-show-promise-in-stopping-glioblastoma-invasion/ Paper DOI - https://doi.org/10.18632/oncotarget.28691 Correspondence to - Maryam Raeeszadeh-Sarmazdeh - maryamr@unr.edu Video short - https://www.youtube.com/watch?v=tdBlkOX50D8 Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28691 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, TIMP minimal variants, glioblastoma multiforme (GBM), brain cancer, MMP inhibitors To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

From Brain Tumor to Bold Faith: Karen's Journey Through Surgery, Glioblastoma & God's Grace In this moving episode of the Fast to Faith Podcast, Karen Bartram shares her unbelievable story—from a small limp and fine motor issues to a devastating diagnosis of a grade 4 glioblastoma. What began as a suspicion of a pinched nerve turned into an emergency room visit, brain surgery, and a life-changing faith journey.Karen walks us through her awake craniotomy, the moments of fear and surrender, and how years of prioritizing her health and spiritual growth prepared her for this unexpected battle. She opens up about combining conventional treatment with holistic healing, and the role prayer, perseverance, and community have played in her resilience. If you've ever wondered where God is in your pain, Karen's story is proof He's been preparing you all along.If you liked this episode, watch it on YouTube!

Dr. Doug Burton refuses to let brain cancer define his days. With unwavering courage, he's embracing every moment, determined to make the most of his time. Now, he's opening up about the groundbreaking treatments that are giving him more chances to laugh, love, and create lasting memories with his family.

ReferencesCureus.2023 Nov 27;15(11):e49521Cell Reports Medicine2024  V5, Issue 91017 28 September 17, Am J Physiol Endocrinol Metab.2013 Feb 12;304(8):E789–E799Guerra, DJ 2025 Unpublished lectures Nardini, Veracini, and Locatelli. 1740's. Violin Sonatas.https://open.spotify.com/album/1bVy95FlClPhHgUMEurvhz?si=VEr5xm4oRB6zGwGwtIAAWg

referencesCureus. 2023 Nov27;15(11):e49521Cell Reports Medicine 2024 V5, Issue 91017 28 September 17, Nature Communications | (2022) 13:6781Cancer Cell. 2020 Jul 9;38(2):167–197.Am J Physiol Endocrinol Metab.2013 Feb 12;304(8):E789–E799.Hunter/Garcia et al.1975. "Blues for Allah" lp. Grateful Dead.https://open.spotify.com/album/5BwjVdVJ4aOmbIYomznfCv?si=1k4STRnoR4SAxG3DVrO0IAHaydn, M. "Requiem in C Minorhttps://open.spotify.com/album/0lr5buO8BDuJGQhBeTgzfR?si=HLCnU3JBSKu596rKZ96eiQ

Season 4 of Glioblastoma aka GBM kicks off Brain Tumor Awareness Month with a closer look at CeGaT, a genetic diagnostics company based in Tübingen, Germany. Founded in 2009 by Dr. Saskia Biskup and Dirk Biskup, CeGaT focuses on identifying rare diseases and tumor-specific mutations through advanced sequencing technologies. In this episode, we speak with Dr. Biskup and Florian Battke, Head of Research & Development, about what genetic sequencing is, how it's used in the context of brain tumors, and what they see as the next frontier for diagnosing and treating diseases like glioblastoma. We discuss how long-read sequencing may offer greater accuracy in identifying genetic changes and what that could mean for patients navigating difficult diagnoses. This episode explores the broader role that genomics can play in brain cancer research and the questions still left to answer as science continues to evolve. To learn more about the work CeGaT is doing, visit them online at https://cegat.com/ This episode is intended for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider for guidance specific to your health or treatment plan.

ReferencesActa Pharm Sin B. 2022 Dec;12(12):4390-4406Cell Death Discov . 2023 Dec 12;9:451.JBC 1997. Volume 272, Issue 36p22432-22437SeptemberCell Metab. 2012 Jun 6;15(6):813–826.Int J Mol Sci. 2022 May 26;23(11):5978Hayward, J. 1967. "The Afternoon " from: Days of future Passed lp.https://open.spotify.com/track/4uCFK6Lm1gA3MaIbSRhIfS?si=48ccbe6f079e469fMcQuinn, R. 1970. "Pale Blue" Byrds lp :Byrdmaniax.https://open.spotify.com/track/46D9uj48T6E8xlSKLv4cEU?si=495da777c73c4929Mozart, WA. 1788. Divertimento in E flat Major. K 563https://open.spotify.com/album/5yxpvtJJTlKUMtUtl9nBcm?si=zc_K0IlzRqOzVVatZs_Pkw

ReferencesCell Death Discov . 2023 Dec 12; 9:451JBC 2025.in Press 10854 . 4AprilActa Pharm Sin B. 2022 Dec;12(12):4390-4406https://www.genecards.org/cgi-bin/carddisp.pl?gene=NAT10Lamm, R. 1972 Dialogues 1&2 Chicago V.https://open.spotify.com/track/6FYcpCjvjTFlKRSSmh13lX?si=04550ed93c724d46Anderson, I. 1972. "Thick as a Brick pt 1. "https://open.spotify.com/track/0eufeeCADKlpxLA7HATWBW?si=23c1fd6f96984c15Schubert, F. 1816;1822. Symphonies 5&8https://open.spotify.com/album/60ozSapXWEc6PZWDh3tllN?si=orEE14UOQvmsDWYYtljvSA

ReferencesJournal of Biological Chemistry 2013. 28.8 52 :37355-37364 Neuro Oncol . 2020 Mar5;22(3):333-344.Front. Cell. Neurosci., 2018 27 NovemberCell Metabolism 2016. Volume 23, Issue 2, Pages 303-314JBC in Press 2025. 10854. 4April. Mydland, B. 1989. "I will Take You Home" Grateful Deadhttps://open.spotify.com/track/1Q3AmIjEbPYemA6UkjUUu0?si=3301b3057df94e04Joel, B. 1979. "Until the Night"https://open.spotify.com/track/3UzWjLQVzCG60gwJdApLqI?si=c0a9ded856c941cdSimon, P. 1965. "April Come She Will"https://open.spotify.com/track/0djZ2ndRfAL69WYNra5jRC?si=da8581de131448b2Mozart, WA. 1787. et al. Symphony 25 K.183 in G minor , plus symphonies 28, and 29https://open.spotify.com/album/3qhUJTpkFjDeM49QidGMQb?si=iUpvUWNfSlyWGSzgvjDKLg

Guest: Lauren Schaff, MD Glioblastomas are fast, aggressive, and resistant to many standard therapies. Dr. Lauren Schaff, a neuro-oncologist at Memorial Sloan Kettering Cancer Center, explains how new molecular understandings and treatment avenues are paving the way for a more personalized, hopeful approach to care.

BUFFALO, NY - April 4, 2025 – A new #research paper was #published in Oncotarget, Volume 16, on March 27, 2025, titled “Imipridones ONC201/ONC206 + RT/TMZ triple (IRT) therapy reduces intracranial tumor burden, prolongs survival in orthotopic IDH-WT GBM mouse model, and suppresses MGMT." Researchers from Brown University, led by first author Lanlan Zhou and corresponding author Wafik S. El-Deiry, have shown that combining a new class of drugs called imipridones with standard glioblastoma treatments significantly improves outcomes in mice. The study tested ONC201 and its analog ONC206 in combination with radiation therapy and the chemotherapy drug temozolomide (TMZ), a regimen referred to as IRT. This triple therapy slowed tumor growth and extended survival in a mouse model of glioblastoma, offering a potential new strategy for one of the most aggressive and treatment-resistant brain cancers. Glioblastoma is a fast-growing brain tumor with a poor prognosis and limited treatment options. Standard care typically includes surgery, radiation, and TMZ, but most patients still face a short life expectancy. While ONC201 and ONC206 are currently being studied in clinical trials as single agents, there has been limited information on how they interact with standard therapies. This study is the first to show that both drugs work synergistically with radiation and TMZ, strengthening their overall effects. The results showed that in both laboratory-grown tumor cells and mice, the triple therapy significantly slowed cancer cell growth, reduced tumor size, and prolonged survival compared to using any single or double treatment. Mice treated with IRT lived an average of 123 days, with some surviving more than 200 days—far longer than the 44 to 103 days observed with other treatment combinations. In addition to directly killing tumor cells, ONC201 and ONC206 lowered the expression of MGMT, a protein that helps tumors resist chemotherapy, making the treatment more effective. The researchers also found that the triple therapy reshaped the tumor environment. It decreased levels of harmful molecules that promote tumor growth and immune evasion while increasing signals that activate the immune system. This dual action—directly attacking tumors and boosting immune responses—adds to the potential impact of this treatment approach. “Overall, our preclinical findings support further exploration of the ONC201 and ONC206 IRT regimen as a potential treatment for GBM and diffuse gliomas with H3K27M mutations.” While these findings are based on preclinical mouse models, they offer strong support for advancing this triple therapy to clinical trials. ONC201 and ONC206 are promising due to their ability to cross the blood-brain barrier and enhance the effects of standard treatment. This combination could lead to more effective therapies for glioblastoma and other hard-to-treat brain tumors. DOI - https://doi.org/10.18632/oncotarget.28707 Correspondence to - Wafik S. El-Deiry - wafik@brown.edu Video short - https://www.youtube.com/watch?v=Q_mXy8mana0 Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28707 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

In this deeply moving episode of Mum's the Word with Kelsey Parker, Kelsey welcomes Louise Fox—mother of “Gorgeous George”—to share the remarkable story of her son's courageous battle with a Glioblastoma brain tumor.Together, they open up about the heartbreak of losing a child and a husband, reflecting on how their families have faced unimaginable loss and found ways to keep going. From the moments that tested their strength to the memories that inspire their mission, Kelsey and Louise offer an honest look at the raw, complex journey of grief.They also discuss the hope that drives them forward: raising awareness, supporting others, and finding purpose in the face of profound sorrow. Tune in for a conversation that reminds us of the unbreakable bond of family—and the power of love to outshine life's darkest days. Hosted on Acast. See acast.com/privacy for more information.

Thank you for joining me for the final bonus episode in this series in which I've been sharing our family's experiences in the last year of our daughter Hannah's life, which spanned from February 2008 through February 2009.  I'll be completing the series today with a wrap-up about the ministry which developed out of Hannah's homegoing.   As always, my desire is to give glory to God and point listeners to hope in Jesus along the way.  I'm so grateful you've joined me over this past year … Your listens and your kind comments have been a blessing to my heart. Click HERE for more information about the While We're Waiting ministry or to register for one of our free retreats.  We'd love to have the opportunity to serve you at an event!I would love to hear your thoughts on the show. Click here to send me a message!** IMPORTANT** - All views expressed by guests on this podcast are theirs alone, and may not represent the Statement of Faith and Statement of Beliefs of the While We're Waiting ministry. We'd love for you to connect with us here at While We're Waiting! Click HERE to visit our website and learn about our free While We're Waiting Weekends for bereaved parentsClick HERE to learn more about our network of While We're Waiting support groups all across the country. Click HERE to subscribe to our YouTube channelClick HERE to follow our public Facebook pageClick HERE to follow us on Instagram Click HERE to follow us on Twitter Click HERE to make a tax-deductible donation to the While We're Waiting ministryContact Jill by email at: jill@whilewerewaiting.org

A friend of ours got us connected with an architect who donated his time and drew up a plan for our dream retreat center.  The facility would incorporate the existing house, adding a large dining room, a commercial kitchen, and ten private guest rooms, each with its own bathroom.  No more bunk beds with creaky plastic mattresses or shared bathrooms!  This gentleman created a beautiful concept drawing and presented it to us one snowy Sunday afternoon.  Then he told us the estimated cost ... One MILLION dollars!  We had $3,000 in our While We're Waiting bank account.  Thank you for joining me for another bonus episode in this series in which I've been sharing our family's experiences in the last year of our daughter Hannah's life, which spanned from February 2008 through February 2009.  This series would not be complete without a discussion of the ministry which developed out of Hannah's homegoing.  If you'll indulge me for a few more bonus episodes, I'd like to share how God used Hannah's storm to birth the While We're Waiting ministry to bereaved parents.  As always, my desire is to give glory to God and point listeners to hope in Jesus along the way.  I would love to hear your thoughts on the show. Click here to send me a message!** IMPORTANT** - All views expressed by guests on this podcast are theirs alone, and may not represent the Statement of Faith and Statement of Beliefs of the While We're Waiting ministry. We'd love for you to connect with us here at While We're Waiting! Click HERE to visit our website and learn about our free While We're Waiting Weekends for bereaved parentsClick HERE to learn more about our network of While We're Waiting support groups all across the country. Click HERE to subscribe to our YouTube channelClick HERE to follow our public Facebook pageClick HERE to follow us on Instagram Click HERE to follow us on Twitter Click HERE to make a tax-deductible donation to the While We're Waiting ministryContact Jill by email at: jill@whilewerewaiting.org

Topics covered : Cancer, Glioblastoma multiforme (GBM), control the controllables, shift in perspective, healthy body and mind, affirmations, positive self talk, appreciation. Alannah Sheehan lives in Tipperary with her husband Martin and their 3 children, Finn (9), Luca (7) and Phoebe (5).And 5 years ago when Phoebe was only a few months old, Alannah was diagnosed with Glioblastoma multiforme, an aggressive type of brain cancer.But today, 5 years on, she's healthy and happy and even though she still has to go for regular scans and deal with the stress and anxiety that goes with that, ultimately, life is good.We spoke 4 years ago but I wanted to chat to her again as she is so inspiring.In this conversation she talks about the power of taking control over what you can control and nourishing your body and mind, every day. Alannah was a chef before her diagnosis and food is her passion. Her go to juice is celery, cucumber and lemon and she drinks it every day.You can subscribe to Alannah's ‘Survive and Thrive' membership to gain access to her delicious recipes, and you can also purchase her gorgeous wellness cards too.Alannah SheehanInstagramALANNAH SHEEHAN (@worth_fighting4) • Instagram photos and videos If you're a fan of what I do, please follow, rate and review in all the usual places.And thanks, as always, for your support of Ready to be Real. Hosted on Acast. See acast.com/privacy for more information.

For three years, we had wonderful bereaved-parent retreats at Family Farm.  As awareness began to grow about the ministry via word-of-mouth, internet searches, and our Facebook presence, our waiting lists also began to grow.  Even with adding more retreat dates at other locations, we could no longer keep up with the demand for these events.And as wonderful as Family Farm is, it was not an ideal location for the types of retreats we were hosting.  After all, it was a children's camp ... complete with bunk rooms filled with bunk beds.  Definitely not ideal for a grieving parent retreat.  Family Farm is also a very busy place, and was only available to us twice a year.So we began to consider some other options.  The ultimate solution would be to have our own retreat facility ... a place where we could host as many events as we needed to, where our attendees could enjoy the privacy of their own rooms and feel comfortable and at home from the moment they walked in the door.Thank you for joining me for another bonus episode in this series in which I've been sharing our family's experiences in the last year of our daughter Hannah's life, which spanned from February 2008 through February 2009.  This series would not be complete without a discussion of the ministry which developed out of Hannah's homegoing.  If you'll indulge me for a few more bonus episodes, I'd like to share how God used Hannah's storm to birth the While We're Waiting ministry to bereaved parents.  As always, my desire is to give glory to God and point listeners to hope in Jesus along the way.  I would love to hear your thoughts on the show. Click here to send me a message!** IMPORTANT** - All views expressed by guests on this podcast are theirs alone, and may not represent the Statement of Faith and Statement of Beliefs of the While We're Waiting ministry. We'd love for you to connect with us here at While We're Waiting! Click HERE to visit our website and learn about our free While We're Waiting Weekends for bereaved parentsClick HERE to learn more about our network of While We're Waiting support groups all across the country. Click HERE to subscribe to our YouTube channelClick HERE to follow our public Facebook pageClick HERE to follow us on Instagram Click HERE to follow us on Twitter Click HERE to make a tax-deductible donation to the While We're Waiting ministryContact Jill by email at: jill@whilewerewaiting.org

That first bereaved-parent retreat in April of 2011 turned out to be above and beyond all we could have ever asked or imagined.  We knew from our experience at the Respite Retreat what God could do when a group of like-minded bereaved parents got together ... but this first While We're Waiting Weekend was such a sweet confirmation of what we believed God was calling us to do.Buoyed by the success of this first event, we quickly scheduled our next retreat for November of 2011.  And you know what?  That retreat almost didn't "make." Thank you for joining me for another bonus episode in this series in which I've been sharing our family's experiences in the last year of our daughter Hannah's life, which spanned from February 2008 through February 2009.  This series would not be complete without a discussion of the ministry which developed out of Hannah's homegoing.  If you'll indulge me for a few more bonus episodes, I'd like to share how God used Hannah's storm to birth the While We're Waiting ministry to bereaved parents.  As always, my desire is to give glory to God and point listeners to hope in Jesus along the way.  I would love to hear your thoughts on the show. Click here to send me a message!** IMPORTANT** - All views expressed by guests on this podcast are theirs alone, and may not represent the Statement of Faith and Statement of Beliefs of the While We're Waiting ministry. We'd love for you to connect with us here at While We're Waiting! Click HERE to visit our website and learn about our free While We're Waiting Weekends for bereaved parentsClick HERE to learn more about our network of While We're Waiting support groups all across the country. Click HERE to subscribe to our YouTube channelClick HERE to follow our public Facebook pageClick HERE to follow us on Instagram Click HERE to follow us on Twitter Click HERE to make a tax-deductible donation to the While We're Waiting ministryContact Jill by email at: jill@whilewerewaiting.org

Over the next few months, we met frequently to discuss plans and pray about our upcoming retreat for bereaved parents.  Several times we drove out to Family Farm and included Stan and Donna May in our planning meetings.Thank you for joining me for another bonus episode in this series in which I've been sharing our family's experiences in the last year of our daughter Hannah's life, which spanned from February 2008 through February 2009.  This series would not be complete without a discussion of the ministry which developed out of Hannah's homegoing.  If you'll indulge me for a few more bonus episodes, I'd like to share how God used Hannah's storm to birth the While We're Waiting ministry to bereaved parents.  As always, my desire is to give glory to God and point listeners to hope in Jesus along the way. I would love to hear your thoughts on the show. Click here to send me a message!** IMPORTANT** - All views expressed by guests on this podcast are theirs alone, and may not represent the Statement of Faith and Statement of Beliefs of the While We're Waiting ministry. We'd love for you to connect with us here at While We're Waiting! Click HERE to visit our website and learn about our free While We're Waiting Weekends for bereaved parentsClick HERE to learn more about our network of While We're Waiting support groups all across the country. Click HERE to subscribe to our YouTube channelClick HERE to follow our public Facebook pageClick HERE to follow us on Instagram Click HERE to follow us on Twitter Click HERE to make a tax-deductible donation to the While We're Waiting ministryContact Jill by email at: jill@whilewerewaiting.org

Brad and I returned home from the Respite Retreat still basking in the glow of the new relationships we'd formed, the things we'd learned from spending time with other bereaved parents, and a renewed hope that it was still possible to have joy in life in spite of our great loss. We had a strong sense that God was calling us into a similar type ministry for those who had lost children, but we had no idea how to move forward with it.  We talked about it a lot, and we sought God's direction, but we just didn't have any kind of catalyst to push us forward. Thank you for joining me for another bonus episode in this series in which I've been sharing our family's experiences in the last year of our daughter Hannah's life, which spanned from February 2008 through February 2009.  This series would not be complete without a discussion of the ministry which developed out of Hannah's homegoing.  If you'll indulge me for a few more bonus episodes, I'd like to share how God used Hannah's storm to birth the While We're Waiting ministry to bereaved parents.  As always, my desire is to give glory to God and point listeners to hope in Jesus along the way. I would love to hear your thoughts on the show. Click here to send me a message!** IMPORTANT** - All views expressed by guests on this podcast are theirs alone, and may not represent the Statement of Faith and Statement of Beliefs of the While We're Waiting ministry. We'd love for you to connect with us here at While We're Waiting! Click HERE to visit our website and learn about our free While We're Waiting Weekends for bereaved parentsClick HERE to learn more about our network of While We're Waiting support groups all across the country. Click HERE to subscribe to our YouTube channelClick HERE to follow our public Facebook pageClick HERE to follow us on Instagram Click HERE to follow us on Twitter Click HERE to make a tax-deductible donation to the While We're Waiting ministryContact Jill by email at: jill@whilewerewaiting.org

Even though I didn't really want to go, and this thing was way outside my comfort zone, Brad and I signed up for the Respite Retreat scheduled for Labor Day Weekend in September of 2010.  We couldn't have known at the time what a profound impact it would have on our lives.  Thank you for joining me for another bonus episode in this series in which I've been sharing our family's experiences in the last year of our daughter Hannah's life, which spanned from February 2008 through February 2009.  This series would not be complete without a discussion of the ministry which developed out of Hannah's homegoing.  If you'll indulge me for a few more bonus episodes, I'd like to share how God used Hannah's storm to birth the While We're Waiting ministry to bereaved parents.  As always, my desire is to give glory to God and point listeners to hope in Jesus along the way. I would love to hear your thoughts on the show. Click here to send me a message!** IMPORTANT** - All views expressed by guests on this podcast are theirs alone, and may not represent the Statement of Faith and Statement of Beliefs of the While We're Waiting ministry. We'd love for you to connect with us here at While We're Waiting! Click HERE to visit our website and learn about our free While We're Waiting Weekends for bereaved parentsClick HERE to learn more about our network of While We're Waiting support groups all across the country. Click HERE to subscribe to our YouTube channelClick HERE to follow our public Facebook pageClick HERE to follow us on Instagram Click HERE to follow us on Twitter Click HERE to make a tax-deductible donation to the While We're Waiting ministryContact Jill by email at: jill@whilewerewaiting.org

During the final days of Hannah's life, many people dropped by the hospice center and left books, gifts, food, and other items for our family.  These kindnesses were so greatly appreciated.Most of these gifts were accompanied by a card indicating who had given them.  But one gift, a book called "Holding On To Hope" by Nancy Guthrie, was accompanied by a card signed only with the initials "plc".  The anonymous person who brought that gift could not have foreseen what an impact it would have in our lives. Thank you for joining me for another bonus episode in this series in which I've been sharing our family's experiences in the last year of our daughter Hannah's life, which spanned from February 2008 through February 2009.  This series would not be complete without a discussion of the ministry which developed out of Hannah's homegoing.  If you'll indulge me for a few more bonus episodes, I'd like to share how God used Hannah's storm to birth the While We're Waiting ministry to bereaved parents.  As always, my desire is to give glory to God and point listeners to hope in Jesus along the way.  I would love to hear your thoughts on the show. Click here to send me a message!** IMPORTANT** - All views expressed by guests on this podcast are theirs alone, and may not represent the Statement of Faith and Statement of Beliefs of the While We're Waiting ministry. We'd love for you to connect with us here at While We're Waiting! Click HERE to visit our website and learn about our free While We're Waiting Weekends for bereaved parentsClick HERE to learn more about our network of While We're Waiting support groups all across the country. Click HERE to subscribe to our YouTube channelClick HERE to follow our public Facebook pageClick HERE to follow us on Instagram Click HERE to follow us on Twitter Click HERE to make a tax-deductible donation to the While We're Waiting ministryContact Jill by email at: jill@whilewerewaiting.org

Thank you for joining me for another bonus episode in this series in which I've been sharing our family's experiences in the last year of our daughter Hannah's life, which spanned from February 2008 through February 2009.  This series would not be complete without a discussion of the ministry which developed out of Hannah's homegoing.  If you'll indulge me for a few more bonus episodes, I'd like to share how God used Hannah's storm to birth the While We're Waiting ministry to bereaved parents.  As always, my desire is to give glory to God and point listeners to hope in Jesus along the way.  I would love to hear your thoughts on the show. Click here to send me a message!** IMPORTANT** - All views expressed by guests on this podcast are theirs alone, and may not represent the Statement of Faith and Statement of Beliefs of the While We're Waiting ministry. We'd love for you to connect with us here at While We're Waiting! Click HERE to visit our website and learn about our free While We're Waiting Weekends for bereaved parentsClick HERE to learn more about our network of While We're Waiting support groups all across the country. Click HERE to subscribe to our YouTube channelClick HERE to follow our public Facebook pageClick HERE to follow us on Instagram Click HERE to follow us on Twitter Click HERE to make a tax-deductible donation to the While We're Waiting ministryContact Jill by email at: jill@whilewerewaiting.org

There never really was any question where Hannah's body would be buried.  There's a beautiful cemetery in Briggsville, Arkansas, where the Sullivan family farm is located.   Hannah spent many happy days at the farm ... hunting, riding 4-wheelers, and just hanging out with her cousins. Occasionally, we would stop at that cemetery and visit the graves of her great grandparents and other relatives. She always loved to walk around and read all the different headstones. It's a beautiful country cemetery, on a hillside with lots of trees and a gorgeous view. We knew that was the right place.Thank you for joining me for another bonus episode of the While We're Waiting podcast in this year-long series in which I share our family's experiences as our teenage daughter Hannah battled glioblastoma brain cancer from February 2008 through February 2009.  My desire is to process through the events of those twelve months with the perspective that 16 years has brought … and point listeners to hope in Jesus along the way.I would love to hear your thoughts on the show. Click here to send me a message!** IMPORTANT** - All views expressed by guests on this podcast are theirs alone, and may not represent the Statement of Faith and Statement of Beliefs of the While We're Waiting ministry. We'd love for you to connect with us here at While We're Waiting! Click HERE to visit our website and learn about our free While We're Waiting Weekends for bereaved parentsClick HERE to learn more about our network of While We're Waiting support groups all across the country. Click HERE to subscribe to our YouTube channelClick HERE to follow our public Facebook pageClick HERE to follow us on Instagram Click HERE to follow us on Twitter Click HERE to make a tax-deductible donation to the While We're Waiting ministryContact Jill by email at: jill@whilewerewaiting.org

BUFFALO, NY - March 3, 2025 – A new #research paper was #published in Oncotarget, Volume 16, on February 28, 2025, titled “Effect of TIMPs and their minimally engineered variants in blocking invasion and migration of brain cancer cells." Elham Taheri and Maryam Raeeszadeh-Sarmazdeh from the University of Nevada, Reno, explored a new approach to slowing the spread of glioblastoma multiforme (GBM), the most aggressive and deadly form of brain cancer. Their study highlights the potential of both natural and engineered molecules to block cancer cell movement, offering a promising strategy to combat this challenging disease. Glioblastoma multiforme is difficult to treat because it quickly spreads into healthy brain tissue, making complete surgical removal nearly impossible. A major driver of this invasive behavior is a group of enzymes called matrix metalloproteinases (MMPs), which break down surrounding tissue and create space for cancer cells to spread. Among them, MMP-9 plays a particularly significant role in GBM progression and resistance to current treatments. To address this challenge, the researchers investigated tissue inhibitors of metalloproteinases (TIMPs), natural MMP blockers, and specially engineered versions designed for better effectiveness. The study used cell line models of GBM to test both TIMP-1 and TIMP-3 and their engineered counterparts (mTC1 and mTC3), specific blockers of MMP-9. “Our study focused on minimal TIMP variants, due to their small molecular size and potential in higher cellular uptake and delivery, to assess their potential in cell-based assays.” The results indicated that the engineered TIMPs were just as effective as, or even better than, the natural ones at reducing cancer cell migration and invasion. These findings are particularly promising because previous attempts to block MMPs with small-molecule drugs faced challenges such as poor selectivity and unwanted side effects. In contrast, these engineered TIMPs offer a more targeted and potentially safer approach. One of the greatest obstacles in treating brain cancer is delivering drugs across the blood-brain barrier, a protective layer that prevents many therapeutic compounds from reaching the brain. To address this, the researchers used cell-penetrating peptides to help the TIMP variants reach and enter cancer cells more effectively. Their results confirmed that the engineered TIMPs successfully reached tumor cells, further increasing their potential as a treatment. Additionally, the study found that these engineered TIMPs did not significantly affect healthy cells at lower doses, suggesting they could be used safely. This makes them strong candidates for further drug development. These findings could lead to new treatment options for GBM, a cancer with very few effective therapies. Future research will focus on testing these TIMP variants in animal models to evaluate their long-term effects and safety. Researchers also plan to investigate whether combining these engineered TIMPs with existing treatments, such as chemotherapy or immunotherapy, could improve outcomes. In summary, given the aggressive nature of GBM and the urgent need for better therapies, this study represents an important step forward. If further research confirms these results, engineered TIMPs could become a valuable tool in the fight against brain cancer, offering new hope for improved treatments and patient survival. DOI - https://doi.org/10.18632/oncotarget.28691 Correspondence to - Maryam Raeeszadeh-Sarmazdeh - maryamr@unr.edu Video short - https://www.youtube.com/watch?v=tdBlkOX50D8 To learn more about Oncotarget, please visit https://www.oncotarget.com. MEDIA@IMPACTJOURNALS.COM

Hannah's life was celebrated at First Baptist Church in Hot Springs on this date sixteen years ago.   We had two goals for the service -- to honor Hannah's life and to point people to Jesus.I remember stepping into the church building feeling so very raw and exposed.  Even though Hannah's death was not a surprise, it was a shock, and I was very much still reeling from effects of that shock.  Walking down that long aisle to be seated in the front row was an incredibly surreal experience. Thank you for joining me for another bonus episode of the While We're Waiting podcast in this year-long series in which I share our family's experiences as our teenage daughter Hannah battled glioblastoma brain cancer from February 2008 through February 2009.  My desire is to process through the events of those twelve months with the perspective that 16 years has brought … and point listeners to hope in Jesus along the way.I would love to hear your thoughts on the show. Click here to send me a message!** IMPORTANT** - All views expressed by guests on this podcast are theirs alone, and may not represent the Statement of Faith and Statement of Beliefs of the While We're Waiting ministry. We'd love for you to connect with us here at While We're Waiting! Click HERE to visit our website and learn about our free While We're Waiting Weekends for bereaved parentsClick HERE to learn more about our network of While We're Waiting support groups all across the country. Click HERE to subscribe to our YouTube channelClick HERE to follow our public Facebook pageClick HERE to follow us on Instagram Click HERE to follow us on Twitter Click HERE to make a tax-deductible donation to the While We're Waiting ministryContact Jill by email at: jill@whilewerewaiting.org

As I've been looking back through all the emails passing back and forth between the newspaper, our friends and family, the church staff, etc., that went on in those days immediately following Hannah's homegoing, I'm struck by how "together" I appeared to be.  My communication skills were intact and I was generally coherent, but I remember none of it.Thank you for joining me for another bonus episode of the While We're Waiting podcast in this year-long series in which I share our family's experiences as our teenage daughter Hannah battled glioblastoma brain cancer from February 2008 through February 2009.  My desire is to process through the events of those twelve months with the perspective that 16 years has brought … and point listeners to hope in Jesus along the way.I would love to hear your thoughts on the show. Click here to send me a message!** IMPORTANT** - All views expressed by guests on this podcast are theirs alone, and may not represent the Statement of Faith and Statement of Beliefs of the While We're Waiting ministry. We'd love for you to connect with us here at While We're Waiting! Click HERE to visit our website and learn about our free While We're Waiting Weekends for bereaved parentsClick HERE to learn more about our network of While We're Waiting support groups all across the country. Click HERE to subscribe to our YouTube channelClick HERE to follow our public Facebook pageClick HERE to follow us on Instagram Click HERE to follow us on Twitter Click HERE to make a tax-deductible donation to the While We're Waiting ministryContact Jill by email at: jill@whilewerewaiting.org

Most families don't have the opportunity to prepare for their child's death the way we did.  We had known for a year that Hannah's cancer could be fatal, and even though we prayed earnestly for earthly healing, we knew from the beginning that God may choose to heal her in Heaven.  And, of course, we eventually reached the point where we knew her death was a certainty unless He dramatically intervened. So in the final days of her life, we frequently discussed what her actual passing might be like.  We'd been assured that it would be peaceful ending when the tumors on her brainstorm caused her to simply cease breathing, and that's how we imagined it.  It would be a beautiful moment as we sang hymns around her bed, maybe even getting a glimpse of a smile on her face as she got her first peek into Heaven.  As you know from yesterday's episode, this was not the case.Thank you for joining me for another bonus episode of the While We're Waiting podcast in this year-long series in which I share our family's experiences as our teenage daughter Hannah battled glioblastoma brain cancer from February 2008 through February 2009.  My desire is to process through the events of those twelve months with the perspective that 16 years has brought … and point listeners to hope in Jesus along the way.I would love to hear your thoughts on the show. Click here to send me a message!** IMPORTANT** - All views expressed by guests on this podcast are theirs alone, and may not represent the Statement of Faith and Statement of Beliefs of the While We're Waiting ministry. We'd love for you to connect with us here at While We're Waiting! Click HERE to visit our website and learn about our free While We're Waiting Weekends for bereaved parentsClick HERE to learn more about our network of While We're Waiting support groups all across the country. Click HERE to subscribe to our YouTube channelClick HERE to follow our public Facebook pageClick HERE to follow us on Instagram Click HERE to follow us on Twitter Click HERE to make a tax-deductible donation to the While We're Waiting ministryContact Jill by email at: jill@whilewerewaiting.org

I woke with a start ten years ago today.  I had slept for several hours without interruption, which had not happened in a long time.  It scared me, and I immediately jumped up to check on Hannah.  She had slept all night, and was still sleeping.  She looked different somehow; better, in fact.  She was sleeping in a more naturally relaxed position and her color seemed to be improved.  Brad came into the room about that time (he and Bethany were staying in a room right next door) and he also thought she seemed better ... Thank you for joining me for another bonus episode of the While We're Waiting podcast in this year-long series in which I share our family's experiences as our teenage daughter Hannah battled glioblastoma brain cancer from February 2008 through February 2009.  My desire is to process through the events of those twelve months with the perspective that 16 years has brought … and point listeners to hope in Jesus along the way.I would love to hear your thoughts on the show. Click here to send me a message!** IMPORTANT** - All views expressed by guests on this podcast are theirs alone, and may not represent the Statement of Faith and Statement of Beliefs of the While We're Waiting ministry. We'd love for you to connect with us here at While We're Waiting! Click HERE to visit our website and learn about our free While We're Waiting Weekends for bereaved parentsClick HERE to learn more about our network of While We're Waiting support groups all across the country. Click HERE to subscribe to our YouTube channelClick HERE to follow our public Facebook pageClick HERE to follow us on Instagram Click HERE to follow us on Twitter Click HERE to make a tax-deductible donation to the While We're Waiting ministryContact Jill by email at: jill@whilewerewaiting.org

The entire time we were at the hospice center had a distinct air of unreality.  The fact that we had reached the point where we were re-living the anniversaries of the events which had brought us to this place just added to that sense of illusion.  Surely this wasn't happening to our family.  Surely this was all some kind of crazy dream.  Surely Hannah was going to be fine. But no ... there we were, in a hospice center with our 17-year-old daughter whose grasp on this life was becoming more tenuous. Thank you for joining me for another bonus episode of the While We're Waiting podcast in this year-long series in which I share our family's experiences as our teenage daughter Hannah battled glioblastoma brain cancer from February 2008 through February 2009.  My desire is to process through the events of those twelve months with the perspective that 16 years has brought … and point listeners to hope in Jesus along the way.I would love to hear your thoughts on the show. Click here to send me a message!** IMPORTANT** - All views expressed by guests on this podcast are theirs alone, and may not represent the Statement of Faith and Statement of Beliefs of the While We're Waiting ministry. We'd love for you to connect with us here at While We're Waiting! Click HERE to visit our website and learn about our free While We're Waiting Weekends for bereaved parentsClick HERE to learn more about our network of While We're Waiting support groups all across the country. Click HERE to subscribe to our YouTube channelClick HERE to follow our public Facebook pageClick HERE to follow us on Instagram Click HERE to follow us on Twitter Click HERE to make a tax-deductible donation to the While We're Waiting ministryContact Jill by email at: jill@whilewerewaiting.org

It's a very surreal thing to write an obituary for your own child.  It's even more surreal when your child is sitting beside you as you write it.After Hannah's doctor confirmed that there was nothing else medically that could be done for her and that unless God intervened in a miraculous way she would be going to Heaven soon, I decided to begin making preparations for her funeral.  If you know me you know I'm a planner by nature, so this was not unusual although the situation certainly was.  I was afraid that once Hannah left for Heaven I would be too distraught to think clearly enough to plan something so important.Thank you for joining me for another bonus episode of the While We're Waiting podcast in this year-long series in which I share our family's experiences as our teenage daughter Hannah battled glioblastoma brain cancer from February 2008 through February 2009.  My desire is to process through the events of those twelve months with the perspective that 16 years has brought … and point listeners to hope in Jesus along the way.I would love to hear your thoughts on the show. Click here to send me a message!** IMPORTANT** - All views expressed by guests on this podcast are theirs alone, and may not represent the Statement of Faith and Statement of Beliefs of the While We're Waiting ministry. We'd love for you to connect with us here at While We're Waiting! Click HERE to visit our website and learn about our free While We're Waiting Weekends for bereaved parentsClick HERE to learn more about our network of While We're Waiting support groups all across the country. Click HERE to subscribe to our YouTube channelClick HERE to follow our public Facebook pageClick HERE to follow us on Instagram Click HERE to follow us on Twitter Click HERE to make a tax-deductible donation to the While We're Waiting ministryContact Jill by email at: jill@whilewerewaiting.org

It's one of the most ancient of all questions, “Why does a good God allow people to suffer in this world?  We're left with three options, and my email from sixteen years ago today discusses them.  Thank you for joining me for another bonus episode of the While We're Waiting podcast in this year-long series in which I share our family's experiences as our teenage daughter Hannah battled glioblastoma brain cancer from February 2008 through February 2009.  My desire is to process through the events of those twelve months with the perspective that 16 years has brought … and point listeners to hope in Jesus along the way.I would love to hear your thoughts on the show. Click here to send me a message!** IMPORTANT** - All views expressed by guests on this podcast are theirs alone, and may not represent the Statement of Faith and Statement of Beliefs of the While We're Waiting ministry. We'd love for you to connect with us here at While We're Waiting! Click HERE to visit our website and learn about our free While We're Waiting Weekends for bereaved parentsClick HERE to learn more about our network of While We're Waiting support groups all across the country. Click HERE to subscribe to our YouTube channelClick HERE to follow our public Facebook pageClick HERE to follow us on Instagram Click HERE to follow us on Twitter Click HERE to make a tax-deductible donation to the While We're Waiting ministryContact Jill by email at: jill@whilewerewaiting.org

On this day sixteen years ago, Hannah received two surprise phone calls, both from well-known musicians who had played a significant role in her life.  Each of them spoke words of encouragement and and gave us special memories with Hannah that we will always treasure.  Thank you for joining me for another bonus episode of the While We're Waiting podcast in this year-long series in which I share our family's experiences as our teenage daughter Hannah battled glioblastoma brain cancer from February 2008 through February 2009.  My desire is to process through the events of those twelve months with the perspective that 16 years has brought … and point listeners to hope in Jesus along the way.I would love to hear your thoughts on the show. Click here to send me a message!** IMPORTANT** - All views expressed by guests on this podcast are theirs alone, and may not represent the Statement of Faith and Statement of Beliefs of the While We're Waiting ministry. We'd love for you to connect with us here at While We're Waiting! Click HERE to visit our website and learn about our free While We're Waiting Weekends for bereaved parentsClick HERE to learn more about our network of While We're Waiting support groups all across the country. Click HERE to subscribe to our YouTube channelClick HERE to follow our public Facebook pageClick HERE to follow us on Instagram Click HERE to follow us on Twitter Click HERE to make a tax-deductible donation to the While We're Waiting ministryContact Jill by email at: jill@whilewerewaiting.org

Many people came to visit us when we were in the hospice center, but only a few actually got to see Hannah during that time. She was never one to like a lot of attention even before she got sick, and I knew she would not be comfortable with visitors, especially in her condition.  We wanted to protect her dignity as much as possible; therefore, only the people we knew she would really want to see were allowed in.  Three of her best friends from elementary school were included in that group. Thank you for joining me for another bonus episode of the While We're Waiting podcast in this year-long series in which I share our family's experiences as our teenage daughter Hannah battled glioblastoma brain cancer from February 2008 through February 2009.  My desire is to process through the events of those twelve months with the perspective that 16 years has brought … and point listeners to hope in Jesus along the way.I would love to hear your thoughts on the show. Click here to send me a message!** IMPORTANT** - All views expressed by guests on this podcast are theirs alone, and may not represent the Statement of Faith and Statement of Beliefs of the While We're Waiting ministry. We'd love for you to connect with us here at While We're Waiting! Click HERE to visit our website and learn about our free While We're Waiting Weekends for bereaved parentsClick HERE to learn more about our network of While We're Waiting support groups all across the country. Click HERE to subscribe to our YouTube channelClick HERE to follow our public Facebook pageClick HERE to follow us on Instagram Click HERE to follow us on Twitter Click HERE to make a tax-deductible donation to the While We're Waiting ministryContact Jill by email at: jill@whilewerewaiting.org

You may recall that on Hannah's last day at Children's Hospital before we moved to hospice, some dear friends brought us a box of Krispy Kreme doughnuts. Hannah ate a couple bites of one, but let us know with her limited communication skills that it wasn't as good as a spudnut.  Now, if you're wondering what in the world a "spudnut" is, let me fill you in. In El Dorado, Arkansas, there is a little hole in the wall called the Spudnut Shoppe, where they make the most delicious doughnuts in the world. I am told that they are made with potato flour ... thus the name.  That little comment resulted in seven dozen spudnuts have been delivered to the hospice center over the next few days!  Thank you for joining me for another bonus episode of the While We're Waiting podcast in this year-long series in which I share our family's experiences as our teenage daughter Hannah battled glioblastoma brain cancer from February 2008 through February 2009.  My desire is to process through the events of those twelve months with the perspective that 16 years has brought … and point listeners to hope in Jesus along the way.I would love to hear your thoughts on the show. Click here to send me a message!** IMPORTANT** - All views expressed by guests on this podcast are theirs alone, and may not represent the Statement of Faith and Statement of Beliefs of the While We're Waiting ministry. We'd love for you to connect with us here at While We're Waiting! Click HERE to visit our website and learn about our free While We're Waiting Weekends for bereaved parentsClick HERE to learn more about our network of While We're Waiting support groups all across the country. Click HERE to subscribe to our YouTube channelClick HERE to follow our public Facebook pageClick HERE to follow us on Instagram Click HERE to follow us on Twitter Click HERE to make a tax-deductible donation to the While We're Waiting ministryContact Jill by email at: jill@whilewerewaiting.org

Today, I have the privilege of speaking with Erik and Susan Totera, who I met when they attended one of our While We're Waiting Weekends in eastern Tennessee.  They join me to share the story of their own personal testimony of second chances, as well as the story of their daughter Reilly ... a remarkable young woman who was blessed with creativity and an entrepreneurial spirit ... and we discuss how their faith is carrying them through her sudden and unexpected death. Their journey is a testament to God's presence in times of deep sorrow and His promise of eternal life, and I believe you'll be blessed by listening in.    Click HERE to learn more about the Our Hearts Are Home spring conference in Lynchburg, Virginia.  Brad and I would love to see you there!  I would love to hear your thoughts on the show. Click here to send me a message!** IMPORTANT** - All views expressed by guests on this podcast are theirs alone, and may not represent the Statement of Faith and Statement of Beliefs of the While We're Waiting ministry. We'd love for you to connect with us here at While We're Waiting! Click HERE to visit our website and learn about our free While We're Waiting Weekends for bereaved parentsClick HERE to learn more about our network of While We're Waiting support groups all across the country. Click HERE to subscribe to our YouTube channelClick HERE to follow our public Facebook pageClick HERE to follow us on Instagram Click HERE to follow us on Twitter Click HERE to make a tax-deductible donation to the While We're Waiting ministryContact Jill by email at: jill@whilewerewaiting.org

I'm not gonna lie ... When we got to the hospice center and found out there was no wifi, I may have freaked out just a little. The emails and messages we received daily from so many wonderful people had become such a part of our lifeline it was hard to imagine being cut off from them.  And writing my daily emails was actually playing a role in keeping me sane.  Leaving Hannah's side to go to Starbucks for wifi access was just not going to work.Thank you for joining me for another bonus episode of the While We're Waiting podcast in this year-long series in which I share our family's experiences as our teenage daughter Hannah battled glioblastoma brain cancer from February 2008 through February 2009.  My desire is to process through the events of those twelve months with the perspective that 16 years has brought … and point listeners to hope in Jesus along the way.I would love to hear your thoughts on the show. Click here to send me a message!** IMPORTANT** - All views expressed by guests on this podcast are theirs alone, and may not represent the Statement of Faith and Statement of Beliefs of the While We're Waiting ministry. We'd love for you to connect with us here at While We're Waiting! Click HERE to visit our website and learn about our free While We're Waiting Weekends for bereaved parentsClick HERE to learn more about our network of While We're Waiting support groups all across the country. Click HERE to subscribe to our YouTube channelClick HERE to follow our public Facebook pageClick HERE to follow us on Instagram Click HERE to follow us on Twitter Click HERE to make a tax-deductible donation to the While We're Waiting ministryContact Jill by email at: jill@whilewerewaiting.org

Brad and I moved a lot during the early years of our marriage ... College, graduate school, first job, second job, etc.  Even after the girls were born, we continued to move frequently.  Moving is always stressful, yet there's usually excitement involved too ... a new house, new neighborhood, new friends.  We were used to moving and all that came along with it.  But today we faced an entirely different kind of move ... Moving Hannah from Arkansas Children's Hospital to a hospice center across town.Thank you for joining me for another bonus episode of the While We're Waiting podcast in this year-long series in which I share our family's experiences as our teenage daughter Hannah battled glioblastoma brain cancer from February 2008 through February 2009.  My desire is to process through the events of those twelve months with the perspective that 16 years has brought … and point listeners to hope in Jesus along the way.I would love to hear your thoughts on the show. Click here to send me a message!** IMPORTANT** - All views expressed by guests on this podcast are theirs alone, and may not represent the Statement of Faith and Statement of Beliefs of the While We're Waiting ministry. We'd love for you to connect with us here at While We're Waiting! Click HERE to visit our website and learn about our free While We're Waiting Weekends for bereaved parentsClick HERE to learn more about our network of While We're Waiting support groups all across the country. Click HERE to subscribe to our YouTube channelClick HERE to follow our public Facebook pageClick HERE to follow us on Instagram Click HERE to follow us on Twitter Click HERE to make a tax-deductible donation to the While We're Waiting ministryContact Jill by email at: jill@whilewerewaiting.org

This day began with Hannah nibbling a Krispy Kreme doughnut and ended with us making decisions about how we wanted to spend our final days with her.  Thank you for joining me for another bonus episode of the While We're Waiting podcast in this year-long series in which I share our family's experiences as our teenage daughter Hannah battled glioblastoma brain cancer from February 2008 through February 2009.  My desire is to process through the events of those twelve months with the perspective that 16 years has brought … and point listeners to hope in Jesus along the way. I would love to hear your thoughts on the show. Click here to send me a message!** IMPORTANT** - All views expressed by guests on this podcast are theirs alone, and may not represent the Statement of Faith and Statement of Beliefs of the While We're Waiting ministry. We'd love for you to connect with us here at While We're Waiting! Click HERE to visit our website and learn about our free While We're Waiting Weekends for bereaved parentsClick HERE to learn more about our network of While We're Waiting support groups all across the country. Click HERE to subscribe to our YouTube channelClick HERE to follow our public Facebook pageClick HERE to follow us on Instagram Click HERE to follow us on Twitter Click HERE to make a tax-deductible donation to the While We're Waiting ministryContact Jill by email at: jill@whilewerewaiting.org

**WARNING** - This post is fairly graphic and could be upsetting to some.  If you are sensitive to discussions of blood, you may wish to skip it.  On this date sixteen years ago today, we found ourselves racing to Arkansas Children's Hospital emergency room in the wee hours of the morning.  Hannah's low platelet levels were the culprit, and after a brief stay in the emergency room, we were admitted.  Surprisingly, her doctors decided to go ahead with the MRI, even with all of this going on.  The results were reviewed with us that afternoon and they were devastating, but not unexpected.  We would soon be faced with decisions we never thought we'd have to make on behalf of our teenage daughter.  But for that night, we just settled into the familiarity of the hospital and tried to get some rest.Thank you for joining me for another bonus episode of the While We're Waiting podcast in this year-long series in which I share our family's experiences as our teenage daughter Hannah battled glioblastoma brain cancer from February 2008 through February 2009.  My desire is to process through the events of those twelve months with the perspective that 16 years has brought … and point listeners to hope in Jesus along the way.I would love to hear your thoughts on the show. Click here to send me a message!** IMPORTANT** - All views expressed by guests on this podcast are theirs alone, and may not represent the Statement of Faith and Statement of Beliefs of the While We're Waiting ministry. We'd love for you to connect with us here at While We're Waiting! Click HERE to visit our website and learn about our free While We're Waiting Weekends for bereaved parentsClick HERE to learn more about our network of While We're Waiting support groups all across the country. Click HERE to subscribe to our YouTube channelClick HERE to follow our public Facebook pageClick HERE to follow us on Instagram Click HERE to follow us on Twitter Click HERE to make a tax-deductible donation to the While We're Waiting ministryContact Jill by email at: jill@whilewerewaiting.org

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It was Valentine's Day.  Exactly one year had passed since Hannah had shown the first symptoms of the brain tumor which was now slowly taking her life.  It had been a roller-coaster year full of MRIs, needle sticks, radiation treatments, chemotherapy, hair loss, platelet infusions, and hospital stays.  We had watched our daughter go from a vibrant, healthy 16-year-old with high academic aspirations to a weak, nearly-blind 17-year-old with the mind of an old woman with Alzheimer's.   But in spite of the physical and mental changes cancer had wrought, it had not stolen her sweet spirit.Thank you for joining me for another bonus episode of the While We're Waiting podcast in this year-long series in which I share our family's experiences as our teenage daughter Hannah battled glioblastoma brain cancer from February 2008 through February 2009.  My desire is to process through the events of those twelve months with the perspective that 16 years has brought … and point listeners to hope in Jesus along the way.I would love to hear your thoughts on the show. Click here to send me a message!** IMPORTANT** - All views expressed by guests on this podcast are theirs alone, and may not represent the Statement of Faith and Statement of Beliefs of the While We're Waiting ministry. We'd love for you to connect with us here at While We're Waiting! Click HERE to visit our website and learn about our free While We're Waiting Weekends for bereaved parentsClick HERE to learn more about our network of While We're Waiting support groups all across the country. Click HERE to subscribe to our YouTube channelClick HERE to follow our public Facebook pageClick HERE to follow us on Instagram Click HERE to follow us on Twitter Click HERE to make a tax-deductible donation to the While We're Waiting ministryContact Jill by email at: jill@whilewerewaiting.org

It was Friday, and time for the junior high Valentine dance, and even though Bethany had been out of school since Tuesday, she had made plans to attend.  Since Brad was available to be home with Hannah, I was able to spend the day with her.  We already had her dress, and I enjoyed taking her to get her hair and make-up done that afternoon at my regular salon.  She had plans to ride to the dance with a group of friends, so I figured once we got her all beautiful, she would head out for the evening and I would see her when she got home.That afternoon, we received a phone call from one of her teachers letting us know that Bethany had been voted as the Valentine Dance princess by her fellow students.  It would be a surprise for Bethany that evening, so she didn't want us to tell her ... She just wanted me to know about it so I could come to the dance and see her crowned if I wanted to.  Of course I wanted to!  We let her leave for the dance with her friends without giving away the surprise, then I drove to the gym so I could be there for the coronation.Thank you for joining me for another bonus episode of the While We're Waiting podcast in this year-long series in which I share our family's experiences as our teenage daughter Hannah battled glioblastoma brain cancer from February 2008 through February 2009.  My desire is to process through the events of those twelve months with the perspective that 16 years has brought … and point listeners to hope in Jesus along the way.I would love to hear your thoughts on the show. Click here to send me a message!** IMPORTANT** - All views expressed by guests on this podcast are theirs alone, and may not represent the Statement of Faith and Statement of Beliefs of the While We're Waiting ministry. We'd love for you to connect with us here at While We're Waiting! Click HERE to visit our website and learn about our free While We're Waiting Weekends for bereaved parentsClick HERE to learn more about our network of While We're Waiting support groups all across the country. Click HERE to subscribe to our YouTube channelClick HERE to follow our public Facebook pageClick HERE to follow us on Instagram Click HERE to follow us on Twitter Click HERE to make a tax-deductible donation to the While We're Waiting ministryContact Jill by email at: jill@whilewerewaiting.org

During our clinic appointment sixteen years ago today, we had the opportunity to chat with Hannah's oncologist while she received her requisite platelet infusion.  She was scheduled for an MRI on Monday, which would tell us a lot about what the future might hold.  Her doctor was very honest with us, explaining that he believed the results would indicate progression of the cancer.  He went on to say that if that was indeed the case, there was very little, if anything, that could be done for her medically from this point on. Thank you for joining me for another bonus episode of the While We're Waiting podcast in this year-long series in which I share our family's experiences as our teenage daughter Hannah battled glioblastoma brain cancer from February 2008 through February 2009.  My desire is to process through the events of those twelve months with the perspective that 16 years has brought … and point listeners to hope in Jesus along the way.I would love to hear your thoughts on the show. Click here to send me a message!** IMPORTANT** - All views expressed by guests on this podcast are theirs alone, and may not represent the Statement of Faith and Statement of Beliefs of the While We're Waiting ministry. We'd love for you to connect with us here at While We're Waiting! Click HERE to visit our website and learn about our free While We're Waiting Weekends for bereaved parentsClick HERE to learn more about our network of While We're Waiting support groups all across the country. Click HERE to subscribe to our YouTube channelClick HERE to follow our public Facebook pageClick HERE to follow us on Instagram Click HERE to follow us on Twitter Click HERE to make a tax-deductible donation to the While We're Waiting ministryContact Jill by email at: jill@whilewerewaiting.org

After hearing the news that we may just have six to eight weeks left with Hannah, Brad and I sat down together and made some decisions.  One was that he would take a leave of absence from his job as her high school principal.  Part of this was just practicality ... as Hannah was able to do less and less for herself, he would be needed to help with her care.  She was basically the same height and weight as me and while we had been managing pretty well so far, I knew I wasn't going to be able to lift her anymore when she could no longer "help" me.  But really, he took the leave of absence in order to spend as much time with Hannah as he could.  And for that same reason, we also made the decision to pull Bethany out of school.  She wasn't learning a thing anyway ... She couldn't focus on school with all that was happening at home.  If she missed six or eight weeks of school and had to repeat a grade, so be it.  We wanted her to have every possible moment she could with her big sister.Thank you for joining me for another bonus episode of the While We're Waiting podcast in this year-long series in which I share our family's experiences as our teenage daughter Hannah battled glioblastoma brain cancer from February 2008 through February 2009.  My desire is to process through the events of those twelve months with the perspective that 16 years has brought … and point listeners to hope in Jesus along the way.I would love to hear your thoughts on the show. Click here to send me a message!** IMPORTANT** - All views expressed by guests on this podcast are theirs alone, and may not represent the Statement of Faith and Statement of Beliefs of the While We're Waiting ministry. We'd love for you to connect with us here at While We're Waiting! Click HERE to visit our website and learn about our free While We're Waiting Weekends for bereaved parentsClick HERE to learn more about our network of While We're Waiting support groups all across the country. Click HERE to subscribe to our YouTube channelClick HERE to follow our public Facebook pageClick HERE to follow us on Instagram Click HERE to follow us on Twitter Click HERE to make a tax-deductible donation to the While We're Waiting ministryContact Jill by email at: jill@whilewerewaiting.org

When we arrived at Children's Hospital sixteen years ago today, the waiting room was packed and every bed in the infusion room was full. It was obvious we had a long wait in front of us. Hannah was completely exhausted just from the ride to Little Rock that morning, and could literally barely sit up in her wheelchair.  The brightness of the waiting room assaulting her dilated pupils made things even more uncomfortable for her.  I didn't know how we were possibly going to make it through the morning.One of the nurses noticed Hannah's struggle, and called us back before it was our turn.  She led us to a conference room which contained one of those pull-out sleep chairs that you find in hospital rooms, and fixed it so Hannah could lay on it while we were waiting for an available bed so she could get her platelets.  She turned on a lamp and then flipped off the light switch as she closed the door behind her, giving Hannah the gift of sweet rest in privacy.Thank you for joining me for another bonus episode of the While We're Waiting podcast in this year-long series in which I share our family's experiences as our teenage daughter Hannah battled glioblastoma brain cancer from February 2008 through February 2009.  My desire is to process through the events of those twelve months with the perspective that 16 years has brought … and point listeners to hope in Jesus along the way.I would love to hear your thoughts on the show. Click here to send me a message!** IMPORTANT** - All views expressed by guests on this podcast are theirs alone, and may not represent the Statement of Faith and Statement of Beliefs of the While We're Waiting ministry. We'd love for you to connect with us here at While We're Waiting! Click HERE to visit our website and learn about our free While We're Waiting Weekends for bereaved parentsClick HERE to learn more about our network of While We're Waiting support groups all across the country. Click HERE to subscribe to our YouTube channelClick HERE to follow our public Facebook pageClick HERE to follow us on Instagram Click HERE to follow us on Twitter Click HERE to make a tax-deductible donation to the While We're Waiting ministryContact Jill by email at: jill@whilewerewaiting.org

From my email 16 years ago ...Every day, we hear from at least one person (usually several people) about how much Hannah's story has touched, or even changed, their life. It is such an incredible blessing to us to hear that, and I want to take a minute to explain why. The night before Hannah's brain surgery last February, she shared a story with us that she had never told us before. Many of you have heard this story; most of you probably have not, so with her permission I want to share it with you now. Thank you for joining me for another bonus episode of the While We're Waiting podcast in this year-long series in which I share our family's experiences as our teenage daughter Hannah battled glioblastoma brain cancer from February 2008 through February 2009.  My desire is to process through the events of those twelve months with the perspective that 16 years has brought … and point listeners to hope in Jesus along the way.I would love to hear your thoughts on the show. Click here to send me a message!** IMPORTANT** - All views expressed by guests on this podcast are theirs alone, and may not represent the Statement of Faith and Statement of Beliefs of the While We're Waiting ministry. We'd love for you to connect with us here at While We're Waiting! Click HERE to visit our website and learn about our free While We're Waiting Weekends for bereaved parentsClick HERE to learn more about our network of While We're Waiting support groups all across the country. Click HERE to subscribe to our YouTube channelClick HERE to follow our public Facebook pageClick HERE to follow us on Instagram Click HERE to follow us on Twitter Click HERE to make a tax-deductible donation to the While We're Waiting ministryContact Jill by email at: jill@whilewerewaiting.org

During this hospital stay, it hit me full force how weary Hannah was becoming.  She had been so strong for so long, and her body (and mind) were finally wearing down.  It was clear that she was in the process of dying, and as much as I didn't want her to go, I also didn't want to push her beyond her limits. I really just wanted to take her home and let her live the time she had left without chemotherapy treatments, platelet infusions, spirometers, and isolation masks.  It was time for her to rest.Thank you for joining me for another bonus episode of the While We're Waiting podcast in this year-long series in which I share our family's experiences as our teenage daughter Hannah battled glioblastoma brain cancer from February 2008 through February 2009.  My desire is to process through the events of those twelve months with the perspective that 16 years has brought … and point listeners to hope in Jesus along the way.I would love to hear your thoughts on the show. Click here to send me a message!** IMPORTANT** - All views expressed by guests on this podcast are theirs alone, and may not represent the Statement of Faith and Statement of Beliefs of the While We're Waiting ministry. We'd love for you to connect with us here at While We're Waiting! Click HERE to visit our website and learn about our free While We're Waiting Weekends for bereaved parentsClick HERE to learn more about our network of While We're Waiting support groups all across the country. Click HERE to subscribe to our YouTube channelClick HERE to follow our public Facebook pageClick HERE to follow us on Instagram Click HERE to follow us on Twitter Click HERE to make a tax-deductible donation to the While We're Waiting ministryContact Jill by email at: jill@whilewerewaiting.org

It may sound strange to say that even though Hannah had been battling brain cancer for nearly a year, she really hadn't been "sick" very much.  Yes, she dealt with ongoing headaches, nausea, low platelets, and fatigue, but for the most part, she had been able to cope with these things and still live her life.  Her only hospitalizations, other than her initial surgery, had been for fevers that spiked up when she was neutropenic.  And during those hospitalizations, we would watch movies or TV shows together (one time we watched the entire Facts of Life series), and she took advantage of the opportunity to order chicken strips and macaroni & cheese from the ACH room service menu any time she wanted them.  Sure, we would rather be home, but we always managed to have some fun together during our hospital stays.This hospitalization was different.  This time she was sick.Thank you for joining me for another bonus episode of the While We're Waiting podcast in this year-long series in which I share our family's experiences as our teenage daughter Hannah battled glioblastoma brain cancer from February 2008 through February 2009.  My desire is to process through the events of those twelve months with the perspective that 16 years has brought … and point listeners to hope in Jesus along the way.I would love to hear your thoughts on the show. Click here to send me a message!** IMPORTANT** - All views expressed by guests on this podcast are theirs alone, and may not represent the Statement of Faith and Statement of Beliefs of the While We're Waiting ministry. We'd love for you to connect with us here at While We're Waiting! Click HERE to visit our website and learn about our free While We're Waiting Weekends for bereaved parentsClick HERE to learn more about our network of While We're Waiting support groups all across the country. Click HERE to subscribe to our YouTube channelClick HERE to follow our public Facebook pageClick HERE to follow us on Instagram Click HERE to follow us on Twitter Click HERE to make a tax-deductible donation to the While We're Waiting ministryContact Jill by email at: jill@whilewerewaiting.org

We were now using a wheelchair exclusively for our trips to Children's Hospital, and had become pretty well resigned to its use away from home.  But as time went on, Hannah was becoming less and less able to walk independently, even in our home.  She began to depend upon one of us to support her as she walked from the living room to her bedroom, and needed assistance to stand from a seated position.  In an effort to allow her more independence, we ordered a walker from medical supply, thinking she could use that to get around the house without always having to wait on one of us to help her.Thank you for joining me for another bonus episode of the While We're Waiting podcast in this year-long series in which I share our family's experiences as our teenage daughter Hannah battled glioblastoma brain cancer from February 2008 through February 2009.  My desire is to process through the events of those twelve months with the perspective that 16 years has brought … and point listeners to hope in Jesus along the way.I would love to hear your thoughts on the show. Click here to send me a message!** IMPORTANT** - All views expressed by guests on this podcast are theirs alone, and may not represent the Statement of Faith and Statement of Beliefs of the While We're Waiting ministry. We'd love for you to connect with us here at While We're Waiting! Click HERE to visit our website and learn about our free While We're Waiting Weekends for bereaved parentsClick HERE to learn more about our network of While We're Waiting support groups all across the country. Click HERE to subscribe to our YouTube channelClick HERE to follow our public Facebook pageClick HERE to follow us on Instagram Click HERE to follow us on Twitter Click HERE to make a tax-deductible donation to the While We're Waiting ministryContact Jill by email at: jill@whilewerewaiting.org