Podcasts about Hg

Bludging on the Blindside is back for 2026! In this week's episode, Roy and HG discuss the return of Rugby League to Las Vegas, the feral pig problem in the country, and whether wisdom is the greatest enemy of Rugby League.

Nereden Edebiyat'ın bu bölümünde, sizlerle birlikte zaman makinesinin izini takip edeceğimiz, Jules Verne gibi isimlerle birlikte anılan, bilim-kurgu türünün önde gelen figürlerinden biri olan H. G. Wells'i tanıyoruz.

 Senior Pastor, Clint PressleyWednesday, February 25, 2026

 HGCS Head of School, Dr. Jimmie QuesinberryWednesday, February 25, 2026

VOV1 - Giữa nhịp sống hối hả của Bangkok, có một cô giáo trẻ người Thái vẫn miệt mài dành cho tiếng Việt một tình yêu thật lạ. Đó là Chari Hamratanaphon hay còn được gọi với tên tiếng Việt là Linh Chi.Yêu tiếng Việt từ những câu chuyện cổHành trình 11 năm gắn bó với tiếng Việt của Linh Chi không bắt đầu từ những lý thuyết khô khan, mà từ sự nồng hậu của con người và sức hút từ những câu chuyện cổ."Cô giáo Montira kể cho em nghe rất là nhiều truyền thuyết Việt Nam rất là hay. Ví dụ như là sự tích Hồ Gươm này, ôi em thích lắm! Em đọc đi đọc lại nên em cảm thấy là em muốn học tiếp và tìm hiểu sâu hơn."Từ những trang sách, Linh Chi đã tìm đến Việt Nam để thực sự "chạm" vào văn hóa. Cô say mê vẻ đẹp của tín ngưỡng thờ Mẫu, sự phong phú của đời sống tâm linh Việt Nam.Cô giáo Chari (Linh Chi) chia sẻ về tình yêu tiếng Việt từ những nếp sống đời thường giản dị

 Pastor, Adult Discipleship, Ric BlaziWednesday, February 18, 2026

 Pastor, Family Discipleship, Missions & Outreach, Kyle ScarlettWednesday, February 18, 2026

Fast hätte es heute keine happycoollove Podcastfolge gegeben, weil ich dachte: Das, was grad offensichtlich passiert bei mir, ist wirklich mega banal. Weil ich manchmal nicht erwarte, dass GOTT, das Universum oder der HG auf so alltägliche Weise zu mir spricht. Ich erwarte auch nicht immer, dass alles mega erhaben oder besonders ist. Jedoch dieses Mal war es ein Song, der mir irgendwie zuerst peinlich war. In dieser Podcastfolge erzähle ich dir, warum ich fast keine neue Episode aufgenommen hätte, obwohl dieses Thema seit Wochen direkt vor mir lag. Ich hatte einen Ohrwurm und ich wollte ihn ignorieren. Weil er mir zu banal erschien. Zu laut und zu wenig Tiefgang. Doch als ich mich endlich nicht mehr gegen den Song wehrte, sondern tatsächlich mal hinhörte, merke ich, wie das Universum mir eigentlich damit ein riesen Geschenk machen wollte, welches ich fast abgelehnt hätte. Wir sprechen heute darüber: ✨ wie innere Führung sich zeigen kann ✨ dass wir Zeichen oft übersehen ✨ weshalb der HEILIGE GEIST nicht unserem spirituellen Ideal entsprechen muss ✨ und wie Offenheit plötzlich Wunder bringt Gemeinsam lesen wir außerdem einen Absatz aus dem Textbuch von Ein Kurs in Wundern (Kapitel 14):

Worship Pastor, John StegemertenWednesday, February 11, 2026

 Family Discipleship Pastor, Campbell BenfieldWednesday, February 11, 2026

🧭 REBEL Rundown 📌 Key Points 💨 HFNC met criteria for non-inferiority to BPAP for preventing intubation or death within 7 days in four of the five ARF subgroups.🧪 Bayesian dynamic borrowing increased power across subgroups but created variable certainty, especially in smaller groups such as COPD.🫁 The immunocompromised hypoxemia subgroup did not meet non-inferiority, leading to early trial stopping for futility.️ Rescue BPAP use, subgroup-specific exclusion criteria, and non-standardized BPAP delivery are important contextual factors that influence how subgroup results should be interpreted. Click here for Direct Download of the Podcast. 📝 Introduction Bilevel Positive Airway Pressure (BPAP) has long been a foundational modality in the management of acute respiratory failure (ARF), particularly in COPD exacerbations and cardiogenic pulmonary edema, where it can rapidly reduce work of breathing and improve gas exchange. It remains a core tool in our respiratory support arsenal.High-flow nasal cannula (HFNC), however, has expanded what we can offer patients by delivering many of the same physiologic benefits through a far more comfortable interface. With high flows, modest PEEP, and effective dead-space washout, HFNC can improve oxygenation and decrease work of breathing while preserving the ability to talk, cough, eat, and interact with staff and family. This combination of physiologic support and tolerability makes HFNC especially attractive in patients where comfort, anxiety, or cardiovascular stability are key considerations, and in settings where prolonged noninvasive support may be needed. Rather than competing with BPAP, HFNC broadens our options in ARF and allows us to better match the modality to the patient and their underlying disease process.The RENOVATE trial set out to answer a high-impact question across five distinct etiologic groups: Is HFNC non-inferior to BPAP (NIV) for preventing intubation or death in acute respiratory failure? 🧾 Paper Azoulay É, et al. High-Flow Nasal Oxygen vs Noninvasive Ventilation in Patients With Acute Respiratory Failure: The RENOVATE Randomized Clinical Trial. JAMA. 2025 PMID: 39657981 🔙Previously Covered On REBEL: HFNC: Part 1 – How It WorksHFNC: Part 2 – Adult and Pediatric IndicationsFLORALI and AVOID TrialFLORALI-2: NIV vs HFNC as Pre-Oxygenation Prior to IntubationThe Pre-AeRATE Trial – HFNC vs NC for RSI ️ What They Did CLINICAL QUESTION Is HFNC non-inferior to BPAP for rate of endotracheal intubation or death at 7 days in patients with acute respiratory failure due to a variety of causes? STUDY DESIGN Multicenter, randomized non-inferiority trial33 Brazilian hospitalsNov 2019 – Nov 2023Adaptive Bayesian hierarchical modeling with dynamic borrowingOpen label, outcome adjudicators blindedPatients were classified into 5 subgroups SUBGROUPS 1. Non-immunocompromised hypoxemiaSpO₂ < 90% on room air orPaO₂ < 60 mm Hg on room air plusIncreased respiratory effort (accessory muscle use, paradoxical breathing, thoracoabdominal asynchrony) orRespiratory rate > 25 breaths/min2. Immunocompromised hypoxemiaDefined as:Use of immunosuppressive drugs for >3 monthsOR high-dose steroids >0.5 mg/kg/dayOR solid organ transplantOR solid tumors or hematologic malignancies (past 5 years)OR HIV with AIDS / primary immunodeficiency3. COPD exacerbation with acidosisHigh clinical suspicion of COPD as primary diagnosisRR >25 with accessory muscle use, paradoxical breathing, and/or thoracoabdominal asynchronyABG: pH 454. Acute cardiogenic pulmonary edema (ACPE)Sudden onset dyspnea and rales± S3 heart soundNo evidence of aspiration, infection, or pulmonary fibrosisCXR consistent with pulmonary edema5. Hypoxemic COVID-19 (added June 2023)Added due to deviations between expected and observed outcome proportionsAny patient across the other 4 groups with PCR-confirmed SARS-CoV-2 infection in any of the above groups POPULATION Inclusion Criteria:≥18 yrs with ARF* in one of 5 pre-defined subgroups excluding COPD was defined by the following:Hypoxemia with SpO₂

Guest - Ross Dove CEO Heritage Global - $HGBLCompanyHeritage Global Inc.Website https://hginc.com/NASDAQ: HGBLBioRoss Dove is the Chief Executive Officer of Heritage Global Inc. (“HG”) and was appointed by the Board as a Class I director in May 2015. He began his career over forty years ago, joining his father and grandfather at a small proud family auction house in San Francisco. During his tenure, he pioneered countless advances and industry firsts, as the firm he joined eventually climbed to become the world's largest and most respected industrial asset and commercial property auction company. Mr. Dove's success has been widely chronicled in major publications, including Fortune, Forbes, the Wall Street Journal, Business Week, and the Economist, among many others. He was twice nominated for EY entrepreneur of the year and is a founding member of the Industrial Auctioneers Association ("IAA") and recipient of the Lifetime Achievement award.Company BioHeritage Global Inc. (NASDAQ: HGBL) a renowned asset-based market maker which delivers result-driven solutions to industrial & financial institutions by providing valuation, and lending services for distressed assets. This aids in facilitating the circular economy by diverting useful industrial assets from landfills and operating an ethical supply chain by overseeing post-sale account activity of financial assets. Specialties consist of acting as an adviser, in addition to acquiring or brokering turnkey manufacturing facilities, surplus industrial machinery and equipment, industrial inventories, real estate, account receivable portfolios, and intellectual property through its two business units: Industrial Assets and Financial Assets

 Discipleship Pastor, Matt Phipps Wednesday, February 4, 2026

 Senior Pastor, Clint PressleyWednesday, February 4, 2026

Die Hohensyburg kennen viele in NRW vor allem als Casino – doch der Syberg über der Ruhr war lange vorher Schauplatz großer Gefühle: Macht und Verteidigung, Erinnerung und Erholung, Status und Inszenierung. Festung und Ruine, Denkmal und Aussichtspunkt, Wallfahrtsziel und Sonntagsausflug – die Hohensyburg ist ein historisch gewachsener Ort des Binnentourismus und eines der prägenden Ausflugsziele der Region.In dieser Folge fragen wir: Wer entscheidet, welche Geschichten über diesen Ort erzählt werden – und warum sie sich verändern? Greta Civis spricht mit David Bendfeld, Friedel Helga Roolfs und Matthias Frese über Namen und Macht, über die militärische Vergangenheit, über die Hohensyburg als westfälische Denkmallandschaft – und darüber, warum der Berg heute zwar kein touristischer Hotspot mehr ist, aber weiterhin großes Potenzial in seinen vielen Geschichten birgt.Da dies die finale Folge der Podcastreihe "Untold Stories" ist, sagen wir danke für eure Unterstützung – und freuen uns, wenn ihr euch kurz Zeit für unsere Umfrage nehmt, um uns beim Verbessern zu helfen. (Umfrage hier.)Zur weiteren Recherche empfehlen wir diesmal:Henriette Brink-Kloke/Elke Schneider, Ein Sonntagsspaziergang auf der Hohensyburg. Bausteine und Fundstücke, Dortmunder Denkmalhefte 12, Dortmund 2020. Abrufbar hier.Philipp R. Hömberg, Die Hohensyburg. Kreisfreie Stadt Dortmund, in: Frühe Burgen in Westfalen, hg. von der Altertumskommission für Westfalen, Heft 15, Münster 2000. Abrufbar hier.Lu Seegers/Matthias Frese/Malte Thießen (Hg.), Kurorte in der Region. Gesellschaftliche Praxis, kulturelle Repräsentationen und Gesundheitskonzepte vom 18. bis 21. Jahrhundert, Göttingen 2024.Das Kaiser-Wilhelm-Denkmal und Porta Westfalica ist Thema der zweiten Folge der Reihe RadiO: Regionalgeschichte auf die Ohren: Mit Malte Thießen und Kathrin Nolte

Imagine feeling so sick during pregnancy that even water won't stay down, that's Hyperemesis Gravidarum (HG), a severe form of morning sickness that can leave women bedridden and depleted. But what if HG isn't just bad luck or genetics? In today's episode, I sit down with Jes Reynolds, who challenges the common myths surrounding HG and reveals how it often signals deeper physiological imbalances, from nutrient deficiencies to hidden toxicities. Together, we explore how holistic preconception prep can transform the way women experience pregnancy, showing that fertility, morning sickness and HG are reflections of overall health, not isolated conditions. Episode Highlights: What is HG? Hyperemesis Gravidarum and how is it different than regular morning sickness? Think HG is purely genetic? Jes challenges that belief, diving into the surprising role of epigenetics and why your genes aren't the full story Discover why HG might be more common and more misunderstood than you think Jes reveals the subtle health clues that may signal increased HG risk and shares how fertility and pregnancy symptoms mirror our overall health What if morning sickness wasn't random, but a message from your body? Learn how deeper imbalances and deficiencies could be at play Jes explains how proactive preconception work can create a healthier pregnancy and even influence future generations If you're LOVING this podcast, please follow and leave a rating and review below.  PLUS FOLLOW MY INSTAGRAM PAGE HERE FOR BITE SIZED TTC TIPS! Related Episode Links: Apply for Private Fertility Coaching with Nora here Click here for a collection of Nora's best self paced programs to get & stay pregnant For full show notes and guest related links: https://www.naturallynora.ca/blog/175  Grab Your FREE Resources: Just starting your TTC journey? Download my Eat To Get Pregnant Guide  Having trouble getting and staying pregnant? Download my Top 3 Things To Do When You're Not Getting Pregnant Wondering what supplements to take to help you conceive? Download my Fertility Foundations Supplement Guide Please Note: The contents of this podcast are for educational and informational purposes only. The information is not to be interpreted as, or mistaken for, clinical advice. Please consult a medical professional or healthcare provider for medical advice, diagnoses, or treatment.  

As always there are spoilers ahead! You can follow the podcast on social media on Threads, Instagram and Bluesky.  If you would like to be a patron of the podcast you can join Patreon and for £3 or $3 a month you can get ad free version of the show. https://www.patreon.com/everyscififilm  First Men on the Moon was written by HG Wells and serialised in The Strand Magazine beginning in 1900. The book was published in 1901 a year before Georges Méliès kicked off science fiction cinema with La Voyage dans la Lune in 1902. (You can learn more about that film in episode number 2 The First Science Fiction Film Ever.)  Then in the swinging 60s as the space race was heating up a collection of brilliant sci-fi filmmakers go together to make a story about a Victorian British scientist going to the moon with his anti-gravity material Cavorite! And yet even the amazing Ray Harryhausen stop motion special effects were not enough to make this film a success. My amazing guests break down the origins and outcomes of this mid-century oddity.  Keith Williams is a Reader in English Literature at the University of Dundee where he runs the science fiction programme. He has a special interest in the pre 1945 period and is the author of the book H.G. Wells, Modernity and the Movies. Matthew Rule-Jones is a senior lecturer in film studies at the University of Exeter and author of the book Science Fiction Cinema and 1950s Britain: Recontextualising Cultural Anxiety. At 6:09 Keith is about to explain the contraption that Robert William Paul was planning based on HG wells Time Machine. I interrupt him as we've covered this in two episodes priot. You can access more information about that on episode 37 The Time Machine: HG Wells' Legacy in 1960s Sci-Fi at timecode 23:07 or in episode 9 The Invisible Man Exposed at timecode 38:29. Chapters 00:00 Intro 02:23 HG Wells, selenites and Georges Méliès Trip to the Moon 06:57 Balancing act: Producer Charles Schneer vs Writer Nigel Kneale. 12:44 Box Office flop 15:12 Dreams of Empire and international cooperation 19:40 Steampunk sensibilities 22:26 The backdrop of the Space Race 26:58 Bedford and Cavor 33:20 Ray Harryhausen 37:50  NASA and the moon landing 41:12 Ant colonies and sci-fi 46:42 Legacy 50:10 Recommendations   Recommendations: The First Men in the Moon (2010) The Stone Tape (1972) available to view on YouTube here: https://www.youtube.com/watch?v=uHgcpzzZspw   NEXT EPISODE! The next episode will feature two films:  Dr Who & the Daleks (1965) as well as Daleks' Invasion Earth 2150 A.D. (1966). These films are available to buy or stream on mainstream platforms like Apple and Prime as well as subscription services. The Just Watch website is a good resource for finding where films are available in your region.

On today's episode, content creator and mama of three Ruby Smoot gets real about the parts of infertility and pregnancy after infertility we don't talk about enough — the mental health spiral, the obsessive thoughts, the fear, and the quiet, heavy darkness that can creep in while you're trying so hard to become a parent. In this deeply candid conversation, Ruby opens up about pregnancy after infertility while battling OCD and intrusive thoughts, navigating severe nausea called hyperemesis gravidarum (HG), and what it felt like to hold hope and despair at the same time, and how becoming pregnant didn't magically erase the mental health struggles she was carrying. Because as many of us know: having babies doesn't fix everything — you still have to heal. She also talks about getting pregnant again, and having HG a second time. Now a mom of three kiddos, Ruby reflects on what she wishes she'd known, how she got support, and why talking honestly about maternal mental health might be the most important thing we can do for each other.Follow her on IG: @rubydu91 And TikTok: ruby.duEPISODE SPONSORS: THE WORK OF ART BOOK SERIESAli's Children's Book Series about IVF, IUI and Family Building Through Assisted Reproductive Technology https://www.infertileafgroup.com/booksThe latest book in the Work of ART series, “You Are a Work of ART," is for every kiddo born through ART -- and the people who love them.Order "Work of ART," "Beautiful Bird" and "You Are a Work of ART," now at https://www.infertileafgroup.com/booksFERTILITY RALLYIG: @fertilityrallywww.fertilityrally.comNo one should go through infertility alone. Join the Worst Club with the Best Members at fertilityrally.com. We offer 5 to 6 support groups per week, three private Facebook groups, tons of curated IRL and virtual events, and an entire community of more than 500 women available to support you, no matter where you are in your journey.Join today at link in bio on IG @fertilityrally or at www.fertilityrally.com/membershipPHERDALIG: @pherdal_sciencePherDal is the world's first and only FDA-cleared, sterile, at-home insemination kit designed to help people build their families in the comfort of home. Created by parents who've been there, PherDal is safe, simple, and affordable—putting more options in your hands as you grow your family. Explore at PherDal.com.Go to PherDal.com today and use code INFERTILEAF for $10 off.BERRY FERTILITYIG: @berry.fertilityThe Berry Fertility app is packed with support: dozens of injection tutorials, over 100 articles, 200 FAQs, and if you still have questions, the Berry team is literally a tap away through in-app chat.Berry has a free version, and you can try Premium free for seven days. After that, it's $12.99 a month or $99 for the year.InfertileAF listeners get 30% off an annual membership with the code INFERTILEAF when you sign up at berryfertility.com or in the Berry Fertility app.Our Sponsors:* BetterHelp makes it easy to get matched online with a qualified therapist. Sign up today and get 10% off at BetterHelp.com Support this podcast at — https://redcircle.com/infertile-af-infertility-and-modern-family-building-through-art/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

 Missions & Outreach Pastor, Kyle ScarlettWednesday, January 28, 2026

 Senior Pastor, Clint PressleyWednesday, January 28, 2026

Selina ist großer Fan von True Crime. Sie sagt, dass echte Kriminalfälle in ihr eine gesunde Angst auslösen. Aber warum ist dieses Genre für viele so faszinierend? Und verändert es etwas in uns und in der Art, wie wir uns im Alltag bewegen?**********Ihr hört: Gesprächspartnerinnen: Selina und Lille hören True-Crime-Podcasts; Doro, hört sie nicht mehr Gesprächspartnerin: Lydia Benecke, Kriminalpsychologin und Autorin Autor und Host: Przemek Żuk Redaktion: Ivy Nortey, Yevgeniya Shcherbakova, Caro Nieder, Friederike Seeger, Anne Bohlmann Produktion: Philipp Adelmann**********Quellen:Browder, L. (2010). "True Crime." In: Nickerson, C. [Hg.]: The Cambridge Companion to American Crime Fiction, 205-28. Cambridge: Cambridge University Press.Sherrill, L. A. (2022). The “Serial Effect” and the True Crime Podcast Ecosystem. Journalism Practice, 16(7), 1473–1494.Podstars by OMR (2025). Podcast-Studie 2025.Perchtold-Stefan, C. (2025). Die Faszination für wahre Kriminalfälle. Psychologische Motive und mögliche Auswirkungen von True Crime-Konsum, SIAK-Journal − Zeitschrift für Polizeiwissenschaft und polizeiliche Praxis (3), 38-54.McDonald, M.M., James, R.M. & Roberto, D.P. (2021). True Crime Consumption as Defensive Vigilance: Psychological Mechanisms of a Rape Avoidance System. Archives of Sexual Behavior 50, 2085–2108 (2021).Alle Quellen findet ihr hier.**********Mehr zum Thema bei Deutschlandfunk Nova:Neurowissenschaften: Was im Hirn passiert, wenn wir Angst habenPhilosophie: Die Macht der AngstHorror: Warum uns Gruseln kickt**********Den Artikel zum Stück findet ihr hier.**********Ihr könnt uns auch auf diesen Kanälen folgen: TikTok und Instagram .**********Meldet euch!Ihr könnt das Team von Facts & Feelings über Whatsapp erreichen.Uns interessiert: Was beschäftigt euch? Habt ihr ein Thema, über das wir unbedingt in der Sendung und im Podcast sprechen sollen?Schickt uns eine Sprachnachricht oder schreibt uns per 0160-91360852 oder an factsundfeelings@deutschlandradio.de.Wichtig: Wenn ihr diese Nummer speichert und uns eine Nachricht schickt, akzeptiert ihr unsere Regeln zum Datenschutz und bei Whatsapp die Datenschutzrichtlinien von Whatsapp.

Student Discipleship Pastor, Jacob PrinceWednesday January 21, 2026

 Senior Pastor, Clint PressleyWednesday January 21, 2026

 Senior Pastor, Clint PressleyWednesday January 14, 2026

 Dr. Jimmie QuesinberryWednesday January 14, 2026

🧭 REBEL Rundown 📌 Key Points 💀 Mortality: No statistically significant difference in 28-day mortality between ketamine vs etomidate for intubation in critically ill patients, though there was a ~1% absolute difference favoring ketamine. 📉🫀⚠️ Hemodynamics: Ketamine induction was associated with more cardiovascular collapse, mainly driven by new/increased vasopressor use (dose escalation or addition of a vasoactive agent). 💉⬆️ Click here for Direct Download of the Podcast. 📝 Introduction Etomidate or ketamine? The debate over the ideal agent for emergency rapid sequence intubation (RSI) has raged for years with no clear winner. Etomidate has been touted in the past for its rapid onset and minimal intrinsic effects on hemodynamics. However, the drug is well known as a transient adrenal suppressant though the impact of this suppression isn’t clear. Ketamine has risen in recent years as an alternative, due to its perceived hemodynamic stability, analgesic properties and absence of adrenal suppression. Additionally, recent data points towards improved mortality when ketamine was selected over etomidate (Kotani 2023). High quality randomized controlled trials are needed to further elucidate which agent should be selected in critically ill patients. 🧾 Paper Casey JD et al. Ketamine or etomidate for tracheal intubation of critically ill adults. NEJM 2025. PMID: 41369227 🔙Previously Covered On REBEL REBEL EM: The EvK Trial: Ketamine vs Etomidate for Rapid Sequence IntubationREBEL EM: From Debate to Data: Emerging Insights into RSI Induction with Ketamine vs Etomidate ️ What They Did CLINICAL QUESTION In critically ill adults undergoing tracheal intubation, does the use of ketamine instead of etomidate result in improved 28 day mortality? STUDY DESIGN Multicenter, randomized, open-label trial in both emergency departments and ICUs. POPULATION Inclusion Criteria:Critically ill patients > 18 years of age undergoing tracheal intubation with the use of an induction agentExclusion Criteria:Known pregnancyPrisonersPrimary diagnosis of traumaNeed for immediate intubation precluding randomizationClinicians determined that the use of ketamine or etomidate was either necessary or contraindicated INTERVENTION & COMPARATOR Intervention (HFNC Group):Ketamine administered based on a provided nomogram: full dose (2.0 mg/kg), intermediate dose (1.5 mg/kg) or reduced dose (1.0 mg/kg)Comparator (BPAP Group):Etomidate administered based on a provided nomogram: full dose (0.3 mg/kg), intermediate dose (0.25 mg/kg) or reduced dose (0.2 mg/kg) OUTCOMES Primary: In-hospital death from any cause by day 28.Secondary:Cardiovascular collapse during intubation defined as SBP < 65 mm Hg, receipt of new or increased dose of vasopressors or cardiac arrest.Exploratory Procedural:Lowest systolic blood pressureLowest systolic blood pressure below 80 mmHgHighest systolic blood pressure above 180 mmHgLowest oxygen saturationLowest oxygen saturation below 80%Successful first attempt intubationTime from induction to intubationExploratory Clinical:Number of ventilator free daysVasopressor-free daysICU free days Safety: Systolic blood pressure at 24 hours after enrollmentOngoing receipt of vasopressors at 24 hours 📈 Results: 2365 patients were randomizedKetamine: 1176Etomidate: 1189> 99% of patients received the drug they were randomized to receiveNMBA: 69% of patients in both groups received rocuronium~ 95% of patients had video laryngoscopy for the primary intubation attempt 💥 Critical Results 💪 Strengths Multicenter ED + ICU cohort of critically ill patients → improves external validityStrong randomization → balanced baseline characteristicsRight population for the question → appropriately focused on a sick cohort where induction choice matters mostHigh protocol adherence → most patients received the agent they were randomized toExcellent follow-up → minimal loss to follow-up / outcome capture ⚠️ Limitations No blinding → potential performance/resuscitation biasTrauma excluded → limits applicability to peri-intubation trauma careCase-mix skewed toward septic shock → may reduce generalizability to other shock etiologiesPower assumptions → designed to detect a 5% mortality difference (possibly overly ambitious)Equipoise-only enrollment → excluded patients with clear indication/contraindication → selection bias + reduced real-world applicabilityComposite secondary outcome with non-equivalent endpoints (e.g., cardiac arrest vs vasopressor titration)Ketamine dosing by actual body weight (vs ideal) → may have increased dose/exposure in some patients 🗣️ Discussion The increase in cardiovascular collapse seen with ketamine was driven by the “new or increased vasopressor use” piece of the composite outcome not by the more clinically relevant severe hypotension (SBP < 65 mm Hg) or cardiac arrest.The increase in CV collapse is a secondary outcome and hypothesis generating onlyCare beyond induction agent isn’t clearly delineated and may have varied between groupsReasons why there was more CV collapse in the ketamine group:Patients in the etomidate group were more likely to be on pressors or have pressor increases prior to induction agent administrationKetamine has analgesic properties which may affect hemodynamics (etomidate does not have analgesic effects)The standard ketamine dose of 2 mg/kg is higher than the induction dose used by most (1-1.5 mg/kg)Ketamine dosing was based on actual body weight though ideal body weight dosing is more accepted. This may have resulted in unnecessarily large ketamine doses that may have had a greater effect on hemodynamics.This is a study of patients with clinical equipoisePatients who the clinician determined would clearly benefit from one agent or the other or in whom one agent or the other was contraindicated were excluded from the study.This may add a selection bias to the results.Clinicians were not blinded to the induction agent administeredThe absence of blinding can introduce bias.For instance, knowledge of the agent the patient was randomized to may result in different resuscitative treatment prior to intubation.An induction agent nomorgram was provided to allow clinicians to choose their induction dose depending on patient stability.A 5% difference in mortality may be overly ambitious. As Josh Farkas points out in his post on this article, PCI for STEMI only has a 3% absolute difference in mortality versus standard care.The 1% absolute difference in mortality while not statistically significant would be clinically significant if it was real. The study would have to be much larger to show a statistically significant 1% difference.About 2% of patients in each group received additional medications during induction (propofol, benzodiazepines, opiates). It is unclear why these agents were selected in specific cases and how they may have affected the outcomes in question. 📘 Author's Conclusion “Among critically ill adults undergoing tracheal intubation, the use of ketamine to induce anesthesia did not result in a significantly lower incidence of in-hospital death by day 28 than etomidate.“ 💬 Our Conclusion In this well done RCT, induction with ketamine did not result in a lower 28-day mortality when compared to induction with etomidate in critically ill adults. The secondary outcome of an increase in cardiovascular collapse is interesting and should be studied more in the future. 🚨 Clinical Bottom Line This data should not drive clinicians to abandon the use of ketamine in RSI. To the contrary, the study leaves open the possibility of a clinically meaningful difference in mortality favoring ketamine that may be borne out in a larger study. However, etomidate can be considered as a first-line option for RSI and may be the superior drug in patients at high-risk for cardiovascular decompensation. Post Peer Reviewed By: Post Peer Reviewed By: Mark Ramzy, DO (X: @MRamzyDO), Frank Lodeserto, MD and Anand Swaminathan, MD (X: @EMSwami) 📚 References Kotani Y et al. Etomidate as an induction agent for endotracheal intubation in critically ill patients: a meta-analysis of randomized trials J Crit Care 2023;77:154317. PMID: 37127020 👤Associate Author Anand Swaminathan MD, MPH All Things REBEL EM Meet The Team 🔎 Your Deep-Dive Starts Here The RSI Trial: Ketamine vs Etomidate in Rapid Sequence Intubation Etomidate or ketamine? The debate over the ideal agent for emergency rapid sequence ... Resuscitation Read More REBEL Cast Ep120: Etomidate vs Ketamine for RSI in the ED? Background: Standard rapid sequence intubation (RSI) in the emergency department involves administration of ... Procedures and Skills Read More The post The RSI Trial: Ketamine vs Etomidate in Rapid Sequence Intubation appeared first on REBEL EM - Emergency Medicine Blog.

 Worship Pastor, John StegemertenWednesday January 7, 2026

 Senior Pastor, Clint PressleyWednesday January 7, 2026

Epicor made sure to start the new year with big news, announcing key milestones in its product innovation strategy, including the schedule of final on-premises feature releases of Epicor Kinetic, Epicor Prophet 21, and Epicor BisTrack. OneStream made headlines announcing it has entered into a definitive agreement to be acquired by Hg, a leading investor in software, services, and data businesses.Connect with us!https://www.erpadvisorsgroup.com866-499-8550LinkedIn:https://www.linkedin.com/company/erp-advisors-groupTwitter:https://twitter.com/erpadvisorsgrpFacebook:https://www.facebook.com/erpadvisorsInstagram:https://www.instagram.com/erpadvisorsgroupPinterest:https://www.pinterest.com/erpadvisorsgroupMedium:https://medium.com/@erpadvisorsgroup

Bis zu 2.500 € Bonus von Scalable Capital. Neu- und Bestandskunden, die Wertpapiere oder Guthaben bei Scalable Capital einzahlen, können sich bis zum 15.01.2026 einen Bonus sichern. Alle Infos gibt's hier: scalable.capital/transfer-bonus. NVIDIA erhöht Prognose und präsentiert Chip früher. Sandisk, Western Digital, Seagate & Aeva hat die Präse gefallen. Johnson Controls, Modine, Trane und Tesla nicht so. AMD auch nicht happy. Advent will InPost. Accenture will KI. HG will OneStream. E-Rezept ist endlich da. Redcare Pharamcy (WKN: A2AR94) ist trotzdem im Keller. Was da los? Dutch Bros (WKN: A3C28Y) schlägt Starbucks. Mit Zucker und eigenem Feiertag. Diesen Podcast vom 07.01.2026, 3:00 Uhr stellt dir die Podstars GmbH (Noah Leidinger) zur Verfügung.

VOV1 - Tối 5/1/2026, tại Nhà hát Hồ Gươm (Hà Nội), Đài Tiếng nói Việt Nam tổ chức chương trình nghệ thuật “Với Đảng vẹn toàn niềm tin yêu” hướng tới Đại hội XIV của Đảng. Chương trình chuyển tải nội dung chính luận, đưa các giá trị tư tưởng đến gần hơn với công chúng thông qua hình thức nghệ thuật.

- Tối 5/1, tại Nhà hát Hồ Gươm, Đài TNVN (VOV) tổ chức Chương trình nghệ thuật “Với Đảng vẹn toàn niềm tin yêu”, chào mừng Đại hội Đại biểu toàn quốc lần thứ 14 của Đảng.- Ngành du lịch cả nước ước đón và phục vụ khoảng 3.500.000 lượt khách trong 4 ngày nghỉ Tết Dương lịch.- Liên minh châu Âu (EU) ra tuyên bố chung bày tỏ quan ngại sâu sắc trước những hệ quả nghiêm trọng phát sinh sau hành động tấn công của Mỹ tại Venezuela, bắt giữ tổng thống Nicolas Maduro.- Indonesia miễn thuế thu nhập trong các ngành nghề thiếu lao động.

On this ENCORE of our most popular episode of 2025, hosts Dr. Mojola Omole and Dr. Blair Bigham speak with two authors of the latest “Hypertension Canada guideline for the diagnosis and treatment of hypertension in adults in primary care”The discussion reflects a shared urgency: despite past successes, Canada's hypertension control rates are declining. The new guidelines aim to reverse this trend by simplifying diagnosis and treatment for frontline clinicians.Dr. Rémi Goupil, a nephrologist and clinician researcher at Sacré-Cœur Hospital in Montreal, and Dr. Greg Hundemer, a nephrologist and clinician scientist at The Ottawa Hospital, explain that the updated guideline is deliberately designed for primary care providers. They highlight key shifts: lowering the diagnostic threshold for hypertension to  ≥ 130/80 mm Hg, simplifying blood pressure targets, and emphasizing accurate, standardized measurement techniques both in clinic and at home. The guidelines were created with input from a majority-primary care committee—including family physicians, nurses, pharmacists, and patient partners—to ensure clinical applicability.Together, the panel outlines a streamlined nine-step treatment algorithm, emphasizing combination therapy as first-line pharmacologic management. They explain the evidence supporting ARB–thiazide combinations, discuss cost considerations for drug selection, and address adherence challenges. They also explore red flags for secondary hypertension and how the algorithm supports—but does not replace—clinical judgment.For physicians, this guideline offers a clear and practical roadmap: measure blood pressure correctly, aim for systolic pressure below 130 mm Hg, and use the simplified treatment sequence to improve adherence and outcomes. Designed to be easy to implement, the new approach aims to empower primary care providers to act with confidenceComments or questions? Text us.Join us as we explore medical solutions that address the urgent need to change healthcare. Reach out to us about this or any episode you hear. Or tell us about something you'd like to hear on the leading Canadian medical podcast.You can find Blair and Mojola on X @BlairBigham and @DrmojolaomoleX (in English): @CMAJ X (en français): @JAMC FacebookInstagram: @CMAJ.ca The CMAJ Podcast is produced by PodCraft Productions

Chris and Britt respond to some great listener questions, discussing which Newcomers they'd want as mentors and what they think of the inter-generational aspects of the HG books. They also make up a few ridiculous Capitol names and laugh a whole lot over Snow and how awkward his family holidays must be. Please tell a geeky friend about us and leave a review on your podcast app! If you really enjoy our content, become one of our amazing patrons to get more of it for just $1 per month here: https://www.patreon.com/geekbetweenthelines Every dollar helps keep the podcast going! You can also buy us a ko-fi for one-time support here: https://ko-fi.com/geekbetweenthelines Please follow us on social media, too: Instagram : https://www.instagram.com/geekbetweenthelines Pinterest : https://www.pinterest.com/geekbetweenthelines Facebook : https://www.facebook.com/geekbetweenthelines Twitter : https://twitter.com/geekbetween Website: https://geekbetweenthelines.wixsite.com/podcast Logo artist: https://www.lacelit.com

Episode 207: Understanding Hypertension and Diabetes (Pidjin English)Written by Michael Ozoemena, MD.You are listening to Rio Bravo qWeek Podcast, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California, a UCLA-affiliated program sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. This podcast was created for educational purposes only. Visit your primary care provider for additional medical advice.HypertensionSegment 1: What Is Hypertension?HOST:Let's start with the basics. Blood pressure is the force of blood pushing against the walls of your arteries. Think of it like water running through a garden hose—if the pressure stays too high for too long, that hose starts to wear out.Hypertension, or high blood pressure, means this pressure is consistently elevated. It is measured using two numbers:Systolic: the pressure when the heart beatsDiastolic: the pressure when the heart relaxesNormally reading is around 120/80 mmHg. Hypertension is defined by the American College of Cardiology/American Heart Association (ACC/AHA) as 130/80 mmHg or higher.The American Academy of Family Physicians (AAFP) defines hypertension as persistent elevation of systolic and/or diastolic blood pressure, with the diagnostic threshold for office-based measurement set at 140/90 mm Hg or higher.Segment 2: Why Should We Care?HOST:Hypertension is known as “the silent killer” because most people have no symptoms. Even without symptoms, it steadily increases the risk of:Heart attackStrokeKidney diseaseThink of high blood pressure as a constant stress test on your blood vessels. The longer it goes uncontrolled, the higher the chance of complications.Segment 3: What Causes High Blood Pressure?HOST:Hypertension usually doesn't have a single cause. It often results from a combination of genetic factors, lifestyle, and underlying medical conditions.Modifiable FactorsHigh-salt diet and low potassium intakePhysical inactivityTobacco useExcessive alcohol intakeOverweight or obesityChronic stressPoor sleep or sleep apneaNon-Modifiable FactorsFamily history of hypertensionBlack race (higher prevalence and severity)Age over 65Hypertension may also be secondary to other conditions, such as kidney disease, thyroid disorders, adrenal conditions, or medications like NSAIDs or steroids.Segment 4: How Is It Diagnosed?HOST:Diagnosis requires multiple elevated blood pressure readings taken on different occasions. This includes office readings, home blood pressure monitoring, or ambulatory blood pressure monitoring.If you haven't had your blood pressure checked recently, this is your reminder. It's simple—and it could save your life.Segment 5: Treatment and ManagementHOST:Lifestyle changes are often the first line of treatment:Reduce salt intakeEat more fruits, vegetables, and whole grainsAim for 150 minutes of moderate exercise per weekManage stressMaintain a healthy weightGet enough sleepLimit alcoholQuit smokingIf these steps aren't enough, medications may be necessary. These include:Diuretics, ACE inhibitors, ARBs, Calcium channel blockers, Beta-blockersYour healthcare provider will choose the best medication based on your health profile.Segment 6: What You Can Do TodayHOST:Here are three simple, actionable steps you can take right now:Check your blood pressure—at a clinic, pharmacy, or at home.Pay attention to your salt intake—much of it is hidden in processed foods.Move more—even a 20-minute daily walk can help reduce blood pressure over time.Small steps can lead to big, lasting improvements.SummaryHypertension may be silent but understanding it gives you power. Early action can add healthy years to your life. Take charge of your blood pressure today.Diabetes1. Wetin Diabetes Be and Wetin E Go Do to Person Body?Q: Wetin diabetes mean?A: Diabetes na sickness wey make sugar (glucose) for person blood too high. E happen because the body no fit produce insulin well, or the insulin wey e get no dey work as e suppose.Q: Wetin go happen if diabetes no dey treated well?A: If diabetes no dey treated well, e fit damage the blood vessels, nerves, kidneys, eyes, and even the heart.2. Wetin Cause Diabetes and Why Black People Suffer Pass?Q: Wetin cause diabetes?A: E no be one thing wey cause diabetes. E dey happen because of mix of gene, lifestyle, environment, and society factors.Q: Why Black/African Americans get diabetes more?A: Black people for America get diabetes more because of long-standing inequality, stress, low access to healthcare, and the kind environment wey many of them dey live in. These things dey make Black people more at risk.3. Diabetes Rates for America and Black People?Q: How many people get diabetes for America?A: For America today, over 38 million people get diabetes, and the number dey rise every year.Q: Why Black people dey suffer diabetes more than White people?A: About 12% of Black adults get diabetes, compared to just 7% for White adults. Black people also dey get the sickness earlier and e dey more severe.4. Signs and Symptoms of Diabetes?Q: Wetin be the early signs of diabetes?A: The early signs no too strong, but when e show, e fit include:Too much urine (polyuria)Thirst (polydipsia)Hunger, tiredness, and blurred visionWounds no dey heal fastTingling for hand or legSometimes weight loss5. How Doctor Go Diagnose Diabetes?Q: How doctor fit confirm say person get diabetes?A: Doctor go do some lab tests to confirm:Fasting Plasma Glucose (FPG): 126 mg/dL (7.0 mmol/L) or higherHbA1c: 6.5% or higher2-hour Oral Glucose Tolerance Test (OGTT): 200 mg/dL (11.1 mmol/L) or higher after person drink glucose.Random Blood Glucose: 200 mg/dL (11.1 mmol/L) or higher plus classic symptoms like too much urination, thirst, or weight loss.Q: Wetin happen if HbA1c test no match the person?A: If HbA1c result no match person symptoms, doctor fit repeat test or try other tests like FPG or OGTT.6. Wetin Screening and Early Diagnosis Fit Do?Q: Why screening for diabetes dey important?A: Screening dey important because early detection fit prevent serious complications from diabetes.Q: How often person go do diabetes test?A: Adults wey get overweight or obesity, between 35–70 years, suppose do diabetes screening every three years. But because Black adults get higher risk, doctors dey start screening earlier and more often.7. How Person Fit Manage Diabetes?Q: Wetin be the best way to manage diabetes?A: The two main ways to manage diabetes be:Lifestyle changes: Eat better food (vegetables, fruits, whole grain, beans, fish, chicken) and exercise regularly.Medicine: If person sugar still high, doctor fit give drugs like metformin, SGLT-2 inhibitors, or GLP-1 receptor agonists.Q: Wetin be SGLT-2 inhibitors and GLP-1 drugs?A: SGLT-2 inhibitors dey help with kidney and heart problems, while GLP-1 drugs dey help with weight loss and prevent stroke.Q: Wetin be first-line treatment for diabetes?A: First-line treatment for diabetes be metformin, unless person no fit tolerate am.Q: How much exercise a person suppose do?A: Person suppose do at least 150 minutes of moderate exercise per week. This fit include things like brisk walking, swimming, or cycling. E also good to add muscle-strength training two or three times weekly to help control sugar.Q: When insulin therapy go be needed?A: Insulin therapy go be needed if person A1c is higher than 10%, or if person dey hospitalized and their glucose dey above the 140-180 range. This go help bring the blood sugar down quickly.8. Wetin Be the Complications of Diabetes?Q: Wetin fit happen if diabetes no dey well-managed?A: Complications fit include kidney disease, blindness, nerve damage, leg ulcers, heart attack, stroke, and emotional issues like depression.Q: Why Black adults get more complications?A: Black people get higher risk of these complications because of inequality, stress, and poor access to healthcare.9. Wetin Dey Affect Access to Diabetes Treatment?Q: Wetin make Black people struggle to get treatment for diabetes?A: Many Black people no dey get new effective treatments like GLP-1 and SGLT-2 inhibitors because of price, insurance issues, and lack of access. COVID-19 also worsen things.Q: Wetin government and doctors fit do?A: Policymakers dey work on improving access to drugs, better community programs, and screening for social issues wey fit affect diabetes care.10. ConclusionQ: Wetin be the solution to reduce diabetes impact?A: The solution go need medical treatment, early screening, lifestyle support, and policy changes. With proper treatment and community support, e possible to reduce the impact of diabetes, especially for Black communities.Even without trying, every night you go to bed a little wiser. Thanks for listening to Rio Bravo qWeek Podcast. We want to hear from you, send us an email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week! _____________________References: Whelton PK, Carey RM. Overview of hypertension in adults. UpToDate. 2024.Carey RM, Moran AE. Evaluation of hypertension. UpToDate. 2024.Mann SJ, Forman JP. Lifestyle modification in the management of hypertension. UpToDate. 2024.Giles TD, Weber MA. Initial pharmacologic therapy of hypertension. UpToDate. 2024.American Heart Association. Understanding Blood Pressure Readings. Accessed 2025.American Heart Association. AHA Dietary and Lifestyle Recommendations. Accessed 2025.Theme song, Works All The Time by Dominik Schwarzer, YouTube ID: CUBDNERZU8HXUHBS, purchased from https://www.premiumbeat.com/.

Michael Himmelfarb is the founder of HG Partners, a consulting firm that advises growing tech companies on monetization and go-to-market strategy. He developed a unique consulting model that combines the advantages of AI with the human superpowers of creativity, empathy, and experience to deliver high-impact results in as little as 48 hours. A former GM of a $200M Nielsen business and a five-time tech CXO, he is passionate about teaching consultants how to leverage AI without losing the human trust advantage. His blog, Reframing Forward, explores the future of AI-enhanced business and work.In today's episode of Smashing the Plateau, you will learn how to use value-based pricing, quick-win offers, and authentic relationship-building to stand out, earn attention, and convert conversations into paid work in a risk-averse market.Michael and I discuss:Michael's path from corporate leadership to independent consulting [01:49]A clear one-sentence offer grounded in value-based pricing [06:24]How to capture attention with show-don't-tell executive summaries and easy-to-buy offers [07:11]Why trust beats automation: using AI with human oversight (and a cautionary math example) [10:47]Practical advice for consultants struggling to convert interest into revenue [12:12]A simple LinkedIn strategy: thoughtful comments that spark real conversations [12:49]Community, collaboration, and helping others as a growth engine [14:23]Drawing the line between giving value and getting paid (share in the upside) [15:52]Cutting through noise: do your own work, use AI for augmentation, quantify outcomes [17:15]Shaping the offer: transactional, advisory, recurring, or loss leader—staying flexible [18:54]An agile, iterative approach to prompts and analysis for better AI outcomes [20:51]The long game of relationships and radical transparency [21:40]Where to explore more of Michael's ideas and connect [23:12]Learn more about Michael at: www.Hg-partners.com, https://reframingforward.substack.com, and linkedin.com/in/michaelhimmelfarbThank you to our sponsor:The Smashing the Plateau Community______________________________________________________________About Smashing the PlateauSmashing the Plateau shares stories and strategies from corporate refugees: mid-career professionals who've left corporate life to build something of their own.Each episode features a candid conversation with someone who has walked this path or supports those who do. Guests offer real strategies to help you build a sustainable, fulfilling business on your terms, with practical insights on positioning, growth, marketing, decision-making, and mindset.Woven throughout are powerful reminders of how community can accelerate your success.______________________________________________________________Take the Next Step• Experience the power of community.Join a live guest session and connect with peers who understand the journey:https://smashingtheplateau.com/guest• Not ready to join live yet? Stay connected.Get practical strategies, stories, and invitations delivered to your inbox:

 Worship Pastor, John StegemertenWednesday November 19, 2025

 Senior Associate Pastor, Dr. Kyler SmithWednesday November 19, 2025

In this transformative episode, Brooke sits down with Jes— a holistic Hyperemesis Gravidarum (HG) coach, root-cause practitioner, and home-birth mother— to discuss a new way forward for women experiencing severe nausea in pregnancy. Jes shares her personal healing journey, how she entered the world of holistic pregnancy support, and why so many women with HG are dismissed within conventional care.Together, they dig into the deeper layers of HG through a root-cause pregnancy and functional medicine lens. Jes breaks down the clues behind HG: antihistamine pathways, B6, minerals, nutrient co-factors, and how modalities like TCM, GNM, Ayurvedic wisdom, and Western medicine can blend to offer more complete holistic pregnancy care. They also explore how to differentiate standard morning sickness from true HG, the biological purpose of nausea and vomiting, and the impact of underlying factors such as H. pylori, trauma, nervous system dysregulation, and chronic depletion.Jes introduces her newest offering, The Human Blueprint, and shares supportive, accessible approaches for women seeking natural HG relief, functional pregnancy support, and deeper understanding during early pregnancy.If you want a compassionate, evidence-informed, and holistic perspective on HG, this episode is essential listening.Where to Find Jes:Instagram: @the_wellness_element & @bornfrom.herWebsite: BornFromHer.comPhotography: @futureselfcreativeConnect:Email us to say hi: ⁠⁠⁠holywildbirth@gmail.com⁠⁠⁠Put in a request for future topics and/or submit a question for future Q&A episodes: ⁠⁠⁠Fill out the form⁠⁠⁠Apply to tell your birth story on the podcast: ⁠⁠⁠Holy Wild Birth Podcast : Guest Application⁠⁠⁠Hang out with us and other Holy Wild Women in our private community (off Facebook): ⁠⁠⁠Rooted in Eden PMA⁠⁠⁠Become a holy, wild birthkeeper with us inside ⁠⁠⁠Hearthmother Journey⁠⁠⁠From Lauren:⁠⁠⁠Instagram⁠⁠⁠Midwifery consults: Email  ⁠⁠⁠rootedinedenpma@gmail.com⁠⁠⁠From Brooke:⁠⁠⁠Instagram⁠⁠⁠⁠⁠⁠Trust God, Trust Birth Workshop⁠⁠⁠ - a 5-part high-level roadmap to a confident home birth (pay what you can)⁠⁠⁠Faith-Filled Home Birth Workshop ⁠⁠⁠- a free, 3-part video series delivered to your inbox⁠⁠⁠Embrace Birth Journey ⁠⁠⁠- comprehensive and holistic faith-based home birth preparation (courses + private community)Intro and Outra Music Credit -Betty Dear By ⁠⁠⁠Blue Dot Sessions⁠⁠⁠ is licensed under a ⁠⁠⁠Creative Commons License⁠⁠⁠.

 Rachel Hindley, Vice President of Corporate Development, IFS  Rachel oversees transformative acquisitions for the global leader in industrial AI and enterprise software. In this episode, Rachel shares how IFS navigates the unique dynamics of having three major private equity backers—EQT, HG, and TA Associates—while executing strategic deals that enhance their portfolio. She breaks down IFS's four acquisition archetypes (product bolt-ons, customer migration, market entry, and new platforms), explains why integration and value creation must be separated, and reveals how the company is adapting its strategy for early-stage AI acquisitions. M&A professionals will learn how to build repeatable frameworks, maintain cultural continuity during integration, and balance stakeholder priorities in complex deal environments. Things you will learn: How to structure M&A around four distinct acquisition archetypes  Why separating systems integration from value creation  How to balance multiple PE stakeholder priorities  ____________________ Share Your M&A Experience for the Chance at $500 Giftcard M&A moved fast in 2025. But what actually changed? We're collecting real insights from practitioners—not consultants on the sidelines—to understand how corp dev teams, PE firms, and advisors are adapting. Takes 10 min. Get early access to results + chance at $500 gift card. Share your experience: https://hubs.ly/Q03Rr89G0 ____________________ Today's episode of the M&A Science Podcast is brought to you by Grata! Grata is the leading private market dealmaking platform. With its best-in-class AI workflows and investment-grade data, Grata helps investors, advisors, and strategic acquirers effortlessly discover, research, and connect with potential targets — all in one sleek, user-friendly interface. Visit grata.com to learn more.  __________________ This episode is brought to you by S&P Global. Today's episode of M&A Science is brought to you by S&P Global Market Intelligence. If you're in corp dev or PE, you know the pain — good private company data is hard to come by. Everyone's still chasing clean, reliable, up-to-date data. I started out using CapIQ Pro for public comps, but didn't realize until recently how deep their private company coverage has gotten. Over 58 million private companies, global reach, and actually usable for real deal work.  This isn't surface-level. You get real metrics — ownership, financials, funding rounds, even asset-level insights. So if you're still toggling between a dozen tools trying to piece together the picture, maybe it's time to stop guessing and start sourcing better.  Learn More Here: https://www.spglobal.com/market-intelligence/en/solutions/products/private-company-data?utm_source=podcast&utm_medium=video&utm_campaign=MAScienceH225  __________________ Episode Chapters [00:02:30] From Tax to Corp Dev – Rachel's unconventional path from PwC tax structuring to leading M&A at a global software company. [00:05:00] Managing Three PE Backers – How IFS leverages deep support from EQT, HG, and TA Associates while navigating different investment horizons and exit expectations. [00:12:30] Four Acquisition Archetypes – Breaking down IFS's strategic framework: product bolt-ons, customer migration, market entry, and new platform deals. [00:18:00] The AI Acquisition Challenge – Why IFS acquired The Loops despite it being smaller and earlier-stage than typical targets, and what it means for their agentic platform. [00:26:00] The Standalone Strategy – How IFS kept Poka as a standalone business to preserve culture and agility while still achieving cross-sell synergies. [00:31:00] In-House Commercial Diligence – Why IFS brings dozens of people into due diligence and keeps most work in-house rather than outsourcing to consultants. [00:37:30] Integration vs. Value Creation – The critical distinction between systems integration and value creation that determines whether deals hit their business case projections. [00:43:00] Cultural Retention Tactics – From MacBooks to Slack, the small decisions that make or break retention of key talent in acquired companies. [00:52:30] Building Trust Before the Deal – Why bilateral deals trump auction processes and how face-to-face relationship building accelerates transaction timelines. [00:59:00] Corporate Venture 2.0 – How fast-moving AI markets are pushing IFS to consider series financing and call options instead of traditional full acquisitions.  __________________ Questions, comments, concerns?Follow Kison Patel for behind-the-scenes insights on modern M&A.

 Senior Associate Pastor, Dr. Kyler SmithWednesday November 12, 2025

 Senior Pastor, Clint PressleyWednesday November 12, 2025

Ogul Uner, MD, invites Ta Chen Peter Chang, MD, a pediatric glaucoma specialist, to review a case of a 9-month-old boy who presented with significant photophobia in both eyes. Examination showed IOP of 32 mm Hg in the right eye and 29 mm Hg in the left eye with moderate optic nerve cupping in both eyes. Dr. Chang shares what additional information he would look for to make a diagnosis of pediatric glaucoma. He also shares insights from the Childhood Glaucoma Research Network, a consortium of glaucoma specialists that has developed a consensus of diagnostic criteria. 

 Student Discipleship Pastor, Jacob PrinceWednesday November 5, 2025

 Senior Pastor, Clint PressleyWednesday November 5, 2025

Effects of Intensive Blood Pressure Control in Patients With Frailty: A Post Hoc Analysis From ESPRIT* Lowering systolic blood pressure to less than 120 mm Hg versus less than 140 mm Hg in patients with high cardiovascular risk with and without diabetes or previous stroke: an open-label, blinded-outcome, randomised trial* Reduction of Antihypertensive Treatment in Nursing Home ResidentsPolysaccharide Conjugate Vaccine against Pneumococcal Pneumonia in Adults* A trial to evaluate the safety and immunogenicity of a 20-valent pneumococcal conjugate vaccine in populations of adults ≥65 years of age with different prior pneumococcal vaccination This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe

Another full serving of red meat on The Chad & Cheese Podcast. Joel unleashes the layoff bloodbath: Amazon axes 14K corporate jobs for automation, Target cuts 1.8K amid sales slumps, GM drops 3K+, Rivian 600, UPS a brutal 48K. Military.com? DOA via Valnet. Chad blames UPS pain on automation, ditching Amazon volume, and shrinking wallets; ties GM to the EV tax-credit cliff—“Trump economy killer!” Joel says companies hate chaos, froze post-election, now tariffs (⅓ each: importer, company, consumer) drip inflation, crushing spending and jobs. Amazon's BlueJay bots are coming for warehouses. Emi (Europe) confirms global instability fuels automation through '27; Target may need holiday humans, but HQ already slashed layers. Mercor—those zygote founders roasted for bias-free matching—pivots to AI-model eval, grabs $350M Series C at $10B. 30K experts at $85/hr tell OpenAI why outputs rock or rot. Chad salutes the “picks-and-shovels” genius; Joel dubs it the mother of pivots. AuditBoard scoops FairNow for AI-governance; Chad smells PE acqui-hire for HG's $180B empire, Joel's skeptical—flat headcount, no terms, RecFest whispers “smoke.” Emi loves Mercor's 500M ARR path, reserves FairNow judgment. iCIMS wakes up: AI Sourcing Agent, turnkey I-9/E-Verify (backgrounds/assessments next), Apply Network adds LinkedIn/Veritone. Chad groans—5 yrs post-Opening.io, 3 post-Candidate.ID, rebranding old tech as “agents” in me-too panic. Joel sees ATS arms race: bundle sourcing/SEO or lose to SmartRecruiter clones. Emi hopes CTO Deepak Pandya saves the day; Chad/Joel want retention—“We've got agents too!” H-1B mess: White House defends $100K fee vs. Chamber lawsuits over fraud/wage suppression. DeSantis bans H-1Bs at FL universities (13.6% biz faculty gone), citing Chinese nationals teaching U.S. policy. Chad recalls 2020 Chamber suit—immigrants power innovation/supply chains. BC runs Reagan ads during NHL, fast-tracks Trump-weary U.S. nurses: 1.4K+ apps, 113 registered, 100+ hired. Joel predicts Canada-wide poach; Emi: fee won't spawn American nurses. Bold (Monster/CB owners) drops 2007 cringe-video: wrinkled CEO, Trumpasaurus, resume subs, predatory paid services. Chad gags at “ick,” slams Jeff Taylor for cheering a flaming brand. Joel: ChatGPT could do better; Emi: euthanize the dead horse—trust gone. Trio signs off with Joel the Chicken & Agent Chad pitching iCIMS mascot gigs. Death, taxes, layoffs—baby.  Chapters00:00 - Intro13:32- Layoffs21:44 - AI News30:29 - iCIMS38:23 - H-1B47:04 - Bold 

Dr. Harlan Krumholz introduces a JACC issue unified around the question of how low to target blood pressure, highlighting growing evidence that aiming near 120 mm Hg improves cardiovascular outcomes without harming quality of life. Several studies from the STEP and ESPRIT trials show that intensive blood pressure control widens retinal arterioles, lowers stroke risk, enhances well-being, and remains safe even in older adults. Long-term follow-up data demonstrate that early initiation of intensive therapy provides lasting cardiovascular protection, while new analyses using the PREVENT equations confirm that higher-risk patients gain the most absolute benefit. The issue underscores that intensive control is both safe and effective, and that the next challenge is implementing these proven strategies consistently in clinical practice.

This week on Bludging on the Blindside, Roy and HG discuss the Broncos and Reece Walsh's stunning performance at the NRL Grand Final, Teddy Swims visits the heritage listed toilets and the 'Year of healing' for Manly ended last weekend.

Pumpkin spice season is here, and the HG crew is diving spoon-first into fall's most festive finds! In this episode, Lisa, Jamie, and Mikey taste-test a pumpkin-packed lineup that's equal parts cozy, crunchy, and surprising. From creamy Nutpods Pumpkin Spice Creamer that turned morning coffee into a fall dream, to Tate's Pumpkin Spice Cookies with their signature crispy crunch, to indulgent Clio Greek Yogurt Pumpkin Spice Bars that nearly stole the show, and even Lesser Evil Pumpkin Spice Popcorn that blended sweet with just the right amount of spice—this haul has something for every pumpkin lover. Tune in as Lisa dishes out her honest ratings, reveals which snacks are worth adding to your fall shopping list, and crowns a few new seasonal favorites. Whether you're a pumpkin fanatic or just pumpkin-curious, you won't want to miss this cozy, craveable episode. And don't forget to head on over to the Foodcast page for a list of all the finds mentioned in the episode!