Podcasts about Hg

This week on Bludging on the Blindside, Roy and HG discuss which tennis superstars have a first class toss, delve into how Rugby League acts as a valve for peace, and ponder whether Andrew Abdo has become the NRL's new music critic.

 Senior Pastor, Clint PressleyWednesday September 10, 2025

 Senior Associate Pastor, Dr. Kyler SmithWednesday September 10, 2025

This week on Bludging on the Blindside, Roy and HG discuss the legend of Aussie Joe Bugner, how strong was his feet? The Ref should never stop the game when a stink breaks out and the idea that poker machine profits should be reinvested directly into the local communities where they were generated.

Inspiring actor Heather Graham, part of Hollywood longevity through decades of great work. Chosen Family; written by, produced, directed, starring HG in a comedy drama of eternally single successful woman who may have met the man of her dreams, or is he. Heather & I in conversation on making the film and other career highlights, enjoy. CHOSEN FAMILY rent / buy digital platforms; Australia EAGLE ENTERTAINMENT also starring Julia Stiles, Odessa Rae, Andrea Savage, Michael Gross, Thomas Lennon, Julie Halston, John Brotherton. https://youtube.com/@movieanalystshaneadambassett?si=nZyw5fHIS4t_KgXj

A-lign founder and CEO Scott Price joins Tom Wallace and Saxon Baum to unpack the “all gas, no brakes” journey behind building a category leader in cybersecurity compliance. Scott traces his roots from Arthur Andersen and the Enron fallout to bootstrapping through 2009, landing the first clients, and evolving from SOC 2 mainstay to a broader, tech-enabled platform. He shares candid lessons from a re-traded 2017 deal, why outside capital served as market validation, and how partnering with FTV and later HG set the stage for scale enterprise expansion, European growth, and smart M&A. We dig into frameworks over tools for AI risk, the rise of CMMC and federal standards, and how Tampa's defense ecosystem fuels elite cybersecurity talent. Plus, leadership chemistry with a CFO, why second acts aren't automatically easier, and a lightning round on Bitcoin, AI's job impact, and the China tech challenge. A masterclass in grit, governance, and growth forward. Hosted on Acast. See acast.com/privacy for more information.

Discipleship Pastor, Dr. Matt PhippsWednesday September 3, 2025 

 Discipleship Pastor, Blake MaxwellWednesday September 3, 2025

It's time for another round of hope versus expectation. The WSL is back, Spurs Women are back, but has anything changed? Lauren, Rosa and HG cousin Caroline assess the squad and try to figure out just how big a job new boss Martin Ho has on his hands. There may be some ranting. But there are also culture picks! Hosted on Acast. See acast.com/privacy for more information.

In dieser Folge dreht sich alles um den Urtext des modernen Horrors – E.T.A. Hoffmanns Der Sandmann (1816). Bei Dr. Horror zu Gast: Prof. Roland Innerhofer, seines Zeichens Dr. Horror-Doktorvater und absolute Koryphäe der Science-Fiction-und Phantastik-Forschung. Gemeinsam gehen die beiden den Horror der Romantik auf den Grund: Was passiert, wenn die Aufklärung mit Phantomen des Irrationalen konfrontiert wird ­– und was, wenn das Irrationale selbst eigentlich ein Effekt der Aufklärung ist? – Was passiert, wenn die neuen Technologien des Bürgertums den Rückfall ins Primitive vorbereiten? – Und, ja, irgendwas mit Freud war auch noch: Böser Vater, Kastrationsdrohung alles mit dabei! Das Dr. Horror Versprechen: Die ultimative Folge für alle, die herausfinden wollen, wo der Horror wirklich herkommt.Mehr zu Roland Innerhofer Wikihttps://de.wikipedia.org/wiki/Roland_InnerhoferUni Wien Seite mit vollständigem Publikationsverzeichnishttps://www.germ.univie.ac.at/roland-innerhofer

Hà Nội không chỉ là phố phường tấp nập mà còn là những ngõ nhỏ đầy ắp “thú ăn chơi” – nơi lưu giữ những hương vị và câu chuyện văn hóa độc đáo.Hôm nay, hãy cùng VOV Giao thông dạo quanh một ngõ nhỏ bên Hồ Gươm, thưởng thức bát phở Thìn truyền thống và một ly cà phê trứng Giảng – hai biểu tượng ẩm thực làm say lòng biết bao thế hệ người Hà Nội…

This week on Bludging on the Blindside, Roy and HG discuss whether NRL teams should play their best players or face a term of imprisonment, does Bunnings Island need a minister of Rugby League first and is it Eric Abetz or Erica Betz? 

 Senior Associate Pastor, Dr. Kyler SmithWednesday August 27, 2025

 Executive Pastor, Steve AdamsWednesday August 27, 2025

Kencan Dengan Tuhan - Minggu, 24 Agustus 2025Bacaan: "Dan marilah kita saling memperhatikan supaya kita saling mendorong dalam kasih dan dalam pekerjaan baik." (Ibrani 10:29)Renungan: Menurut cerita, HG. Spafford seorang penulis lagu rohani "It Is Well With My Soul" menuliskan lagu ini ketika ia sedang melintasi lautan atlantik. Di laut itulah ketiga anaknya mati tenggelam ketika mereka sedang berlayar ke Eropa. Cobaan yang dialami Spafford memang luar biasa karena beberapa tahun kemudian anaknya yang lain meninggal karena sakit. Setelah peristiwa itu orang-orang di gereja mengucilkan mereka karena beranggapan bahwa keluarga ini berhubungan dengan kuasa iblis. Spafford masih sanggup berdiri ketika ketiga anaknya diambil dari padanya. Kemudian disusul dengan kematian anaknya yang lain. la tabah menerima semua itu. Tetapi apa yang terjadi ketika saudara-saudara seimannya mengucilkan dan memisahkan diri darinya? Ia tidak kuat lagi menahannya. Jiwanya hancur dan pada akhirnya ia menderita sakit jiwa. Kita harus mengakui bahwa kekuatan kita untuk menanggung segala sesuatunya sangat terbatas. Kita membutuhkan kekuatan dan kemampuan yang berasal dari luar diri kita sendiri. Kekuatan dari Tuhan itu sudah pasti. Tetapi dukungan dari orang-orang di sekeliling kita juga banyak diharapkan. Saudara-saudara seiman, anak, istri, suami, sahabat dan semua orang yang kita kasihi. Mereka inilah yang senantiasa mendoakan dan memberikan dukungan moril. Kita tidak bisa hidup sendiri karena tanpa keberadaan orang-orang di sekeliling kita mungkin kita tidak bisa berada dalam posisi seperti sekarang ini. Marilah kita mulai membina relasi yang baik dengan orang-orang di sekitar kita. Merekalah yang akan Tuhan pakai menjadi penopang di saat kita terjatuh. Kalau saat ini ada kenalan atau orang-orang yang terdekat dengan kita sedang mengalami pergumulan hidup yang berat, buka hati kita dan ulurkanlah tangan kita untuk membantunya, dan mulut kita untuk mendoakannya. Tuhan mau memakai kita untuk menjadi berkat bagi orang lain. Tuhan Yesus memberkati.Doa:Tuhan Yesus, kuasailah diriku sepenuhnya, agar kehadiranku dapat memberi ketenangan bagi orang-orang di sekitarku yang saat ini mengalami pergumulan hidup yang berat. Jangan biarkan kesibukanku membuat aku kehilangan berkat untuk menolong orang yang sedang kesusahan. Amin. (Dod).

This week on Bludging on the Blindside, Roy and HG discuss the Tszyu brothers - the Soul taker and the Butcher,The plight of the Dora Creek Swampies & the Northern Bullants, a Titans open day could save Des, Bait off - knock over a feral, do ex players make the best coaches? Believe in rugby league values, taming Snoop Dog (Mr Rude) for the granny and if you don't like your family... make them up.

VOV1 - Tiến sĩ khí tượng thuỷ văn Nguyễn Thị Minh Phương hơn 10 năm nay cùng cộng sự luôn nhặt rác xung quanh khu vực Hồ Gươm. Hoạt động này không chỉ gieo mầm ý thức giữ vệ sinh môi trường trong cộng đồng, mà còn là hành động thiết thực trong phong trào làm đẹp Thủ đô mừng 80 năm Quốc khánh.

This is a hybrid heart disease risk factor post of a podcast with Prof Bruce Lanphear on lead and a piece I was asked to write for the Washington Post on risk factors for heart disease.First, the podcast. You may have thought the problem with lead exposure was circumscribed to children, but it's a much bigger issue than that. I'll concentrate on the exposure risk to adults in this interview, including the lead-estrogen hypothesis. Bruce has been working on the subject of lead exposure for more than 30 years. Let me emphasize that the problem is not going away, as highlighted in a recent New England Journal of Medicine piece on lead contamination in Milwaukee schools, “The Latest Episode in an Ongoing Toxic Pandemic.”Transcript with links to the audio and citationsEric Topol (00:05):Well, hello. This is Eric Topol with Ground Truths, and I'm very delighted to welcome Professor Bruce Lanphear from Simon Fraser University in British Columbia for a very interesting topic, and that's about lead exposure. We tend to think about lead poisoning with the Flint, Michigan, but there's a lot more to this story. So welcome, Bruce.Bruce Lanphear (00:32):Thank you, Eric. It's great to be here.Eric Topol (00:33):Yeah. So you had a New England Journal of Medicine (NEJM) Review in October last year, which was probably a wake up to me, and I'm sure to many others. We'll link to that, where you reviewed the whole topic, the title is called Lead Poisoning. But of course it's not just about a big dose, but rather chronic exposure. So maybe you could give us a bit of an overview of that review that you wrote for NEJM.Bruce Lanphear (01:05):Yeah, so we really focused on the things where we feel like there's a definitive link. Things like lead and diminished IQ in children, lead and coronary heart disease, lead and chronic renal disease. As you mentioned, we've typically thought of lead as sort of the overt lead poisoning where somebody becomes acutely ill. But over the past century what we've learned is that lead is one of those toxic chemicals where it's the chronic wear and tear on our bodies that catches up and it's at the root of many of these chronic diseases that are causing problems today.Eric Topol (01:43):Yeah, it's pretty striking. The one that grabbed me and kind of almost fell out of my chair was that in 2019 when I guess the most recent data there is 5.5 million cardiovascular deaths ascribed to relatively low levels, or I guess there is no safe level of lead exposure, that's really striking. That's a lot of people dying from something that cardiology and medical community is not really aware of. And there's a figure 3 [BELOW] that we will also show in the transcript, where you show the level where you start to see a takeoff. It starts very low and by 50 μg/liter, you're seeing a twofold risk and there's no threshold, it keeps going up. How many of us do you think are exposed to that type of level as adults, Bruce?Bruce Lanphear (02:39):Well, as adults, if we go back in time, all of us. If you go back to the 1970s when lead was still in gasoline, the median blood lead level of Americans was about 13 to 15 µg/dL. So we've all been exposed historically to those levels, and part of the reason we've begun to see a striking decline in coronary heart disease, which peaked in 1968. And by 1978, there was a 20% decline, 190,000 more people were alive than expected. So even in that first decade, there was this striking decline in coronary heart disease. And so, in addition to the prospective studies that have found this link between an increase in lead exposure and death from cardiovascular disease and more specifically coronary heart disease. We can look back in time and see how the decline in leaded gasoline led to a decline in heart disease and hypertension.Eric Topol (03:41):Yeah, but it looks like it's still a problem. And you have a phenomenal graph that's encouraging, where you see this 95% reduction in the lead exposure from the 1970s. And as you said, the factors that can be ascribed to like getting rid of lead from gasoline and others. But what is troubling is that we still have a lot of people that this could be a problem. Now, one of the things that was fascinating is that you get into that herbal supplements could be a risk factor. That we don't do screening, of course, should we do screening? And there's certain people that particularly that you consider at high risk that should get screened. So I wasn't aware, I mean the one type of supplements that you zoomed in on, how do you say it? Ayurvedic?Supplements With LeadBruce Lanphear (04:39):Oh yeah. So this is Ayurvedic medicine and in fact, I just was on a Zoom call three weeks ago with a husband and wife who live in India. The young woman had taken Ayurvedic medicine and because of that, her blood lead levels increased to 70 µg/dL, and several months later she was pregnant, and she was trying to figure out what to do with this. Ayurvedic medicine is not well regulated. And so, that's one of the most important sources when we think about India, for example. And I think you pointed out a really important thing is number one, we don't know that there's any safe level even though blood lead levels in the United States and Europe, for example, have come down by over 95%. The levels that we're exposed to and especially the levels in our bones are 10 to 100 times higher than our pre-industrial ancestors.Bruce Lanphear (05:36):So we haven't yet reached those levels that our ancestors were exposed to. Are there effects at even lower and lower levels? Everything would suggest, we should assume that there is, but we don't know down below, let's say one microgram per deciliter or that's the equivalent of 10 parts per billion of lead and blood. What we also know though is when leaded gasoline was restricted in the United States and Canada and elsewhere, the companies turned to the industrializing countries and started to market it there. And so, we saw first the epidemic of coronary heart disease in the United States, Canada, Europe. Then that's come down over the past 50 years. At the same time, it was rising in low to middle income countries. So today over 95% of the burden of disease from lead including heart disease is found in industrializing countries.Eric Topol (06:34):Right. Now, it's pretty striking, of course. Is it true that airlines fuel is still with lead today?Bruce Lanphear (06:45):Well, not commercial airlines. It's going to be a small single piston aircraft. So for example, when we did a study down around the Santa Clara County Airport, Reid-Hillview, and we can see that the children who live within a half mile of the airport had blood lead levels about 10% higher than children that live further away. And the children who live downwind, 25% higher still. Now, nobody's mapped out the health effects, but one of the things that's particularly troubling about emissions from small aircraft is that the particle size of lead is extraordinarily small, and we know how nanoparticles because they have larger surface area can be more problematic. They also can probably go straight up into the brain or across the pulmonary tissues, and so those small particles we should be particularly worried about. But it's been such a long journey to try to figure out how to get that out of aircraft. It's a problem. The EPA recognized it. They said it's an endangerment, but the industry is still pushing back.Eric Topol (07:55):Yeah, I mean, it's interesting that we still have these problems, and I am going to in a minute ask you what we can do to just eradicate lead as much as possible, but we're not there yet. But one study that seemed to be hard to believe that you cited in the review. A year after a ban leaded fuel in NASCAR races, mortality from coronary heart disease declined significantly in communities near racetracks. Can you talk about that one because it's a little bit like the one you just mentioned with the airports?Bruce Lanphear (08:30):Yeah. Now that study particularly, this was by Alex Hollingsworth, was particularly looking at people over 65. And we're working on a follow-up study that will look at people below 65, but it was quite striking. When NASCAR took lead out of their fuel, he compared the rates of coronary heart disease of people that live nearby compared to a control group populations that live further away. And he did see a pretty striking reduction. One of the things we also want to look at in our follow-up is how quickly does that risk begin to taper off? That's going to be really important in terms of trying to develop a strategy around preventing lead poisoning. How quickly do we expect to see it fall? I think it's probably going to be within 12 to 24 months that we'll see benefits.Eric Topol (09:20):That's interesting because as you show in a really nice graphic in adults, which are the people who would be listening to this podcast. Of course, they ought to be concerned too about children and all and reproductive health. But the point about the skeleton, 95% of the lead is there and the main organs, which we haven't mentioned the kidney and the kidney injury that occurs no less the cardiovascular, the blood pressure elevation. So these are really, and you mentioned not necessarily highlighted in that graphic, but potential cognitive hit as well. You also wrote about how people who have symptoms of abdominal pain, memory impairment, and high blood pressure that's unexplained, maybe they should get a blood level screening. I assume those are easy to get, right?Bruce Lanphear (10:17):Oh yeah, absolutely. You can get those in any hospital, any clinic across the country. We're still struggling with having those available where it's most needed in the industrializing countries, but certainly available here. Now, we don't expect that for most people who have those symptoms, lead poisoning is going to be the cause, right. It'd still be unusual unless you work in an industry, for example, smelting batteries to recycle them. We don't expect it to be real common, and we're not even sure, Eric, whether we should be doing widespread screening. If I looked at this as a population scientist, the real focus should be on identifying the sources. We mostly know where those are here and radically moving it down. Getting rid of the lead service lines, which was such a big part of what President Biden was doing, and it was perfect. For every dollar invested to reduce lead exposure from those lead service lines. Ronnie Levin at Harvard said there'd be a 35-fold return in cost, benefits really, and this has always been true, that reducing lead exposure throughout the past 40 years has always been shown to be amazingly cost beneficial. The problem is operating within a free market health system, even though there's tremendous social benefits, that benefit isn't going to be monetized or privatized. And so, who's going to make those decisions? We hope our government is, but that doesn't always play out.Eric Topol (11:52):Well. What's interesting is, as opposed to the problems we have today that are prominent such as the microplastic, nanoplastics, the air pollution, the forever chemicals, that just keep getting worse, I mean, they are just cumulative. This one, there was tremendous improvement, but it's still not enough. And I guess you're zooming in on the lead lines. That'd be the most important thing to work on today. Another thing that has come up, there's been trials, as you may I'm sure, because all over this field of chelation, there's a trial that was run by the NIH, supported by NH that looked at chelation to prevent coronary disease. Is there any evidence that people who have a problem with lead would benefit from chelation therapy?Bruce Lanphear (12:44):Well, there's two major studies that have been done, and Tony Lamas was in charge of both of them. The first one Trial to Assess Chelation Therapy (TACT) study, it was a randomized controlled trial, not intended specifically to focus on lead, but rather it was to look at sort of this alternative therapy. They found significant benefits about an 18% reduction in subsequent cardiac events. That led to a second study that was just published last year, and it was focused on people who had diabetes. They saw some benefit, but it wasn't significant. So whether that's because there wasn't enough variability and exposure, it's not entirely clear, but we've seen this with lead in IQ deficits in kids where we can show that we can reduce blood lead levels. But ultimately what tends to happen is once you've taken lead out of the blood, some of it's released again from the bone, but you still have all that lead in the bone that's there. You get some of it out, but you're not going to get the bulk of it out.The Lead-Estrogen HypothesisEric Topol (13:47):Right. It's a reservoir that's hard to reckon with. Yeah. Now another thing, you have a Substack that is called Plagues, Pollution & Poverty, and you wrote a really provocative piece in that earlier and April called How Estrogen Keeps Lead - and Heart Attacks - in Check, and basically you got into the lead estrogen hypothesis.Eric Topol (14:10):Can you enlighten us about that?Bruce Lanphear (14:12):Yeah. A lot of the seminal work in this area was done by Ellen Silbergeld, who's a brilliant and somewhat peculiar toxicologist and Ellen for years, I focused on childhood lead exposure, and for years Ellen would tell me, almost demolish me for not studying adults. And because she had found back in 1988 that as women go into menopause, their blood lead levels spike increased by about 30%, and that's where most of our lead is stored is in our bone. And so, as I was thinking about this, it all became clear because blood lead levels in boys and girls is about the same. It's comparable up until menarche, and then girls young women's blood leads fall by about 20%. And they stay 20% lower throughout the reproductive years until menopause. And especially during those first few years around menopause, perimenopause, you see fairly striking increases in the weakening of the bone and blood lead levels.Bruce Lanphear (15:19):So that might very well help to explain why estrogen is protected, because what happens is throughout the reproductive life, women are losing a little bit of lead every month. And estrogen is at its lowest during that time, and that's going to be when blood lead is at its highest because estrogen pushes lead into the bone. Not only that, women lose lead into the developing fetus when they're pregnant. So what Ellen found is that there was less of a spike around menopause for the women that had three or four pregnancies because they had offloaded that into their babies. So all of this, if you put it together, and this is of course in a very short note of it, you can see that lead increases dyslipidemia, it leads to tears in the endothelium of the arterial wall, it's going to increase thrombosis. All of these things that we think of as the classic atherosclerosis. Well, what estrogen does is the opposite of those. It decreases dyslipidemia, it repairs the arterial endothelial wall. So how much of it is that estrogen is protective, and how much is it that it's moving lead out of the system, making it less biologically available?Eric Topol (16:46):Yeah, I know. It's really interesting. Quite provocative. Should be followed up on, for sure. Just getting to you, you're a physician and epidemiologist, MD MPH, and you have spent your career on this sort of thing, right? I mean, is your middle name lead or what do you work on all the time?Bruce Lanphear (17:09):Yeah, I've been doing this for about 30 years, and one of my mentors, Herb Needleman spent 40 years of his career on it. And in some ways, Eric, it seems to me particularly in these very difficult entrenched problems like lead, we don't have any pharmaceutical company reaching out to us to promote what we do. We've got industry trying to squash what we do.Bruce Lanphear (17:35):It really does take a career to really make a dent in this stuff. And in a way, you can look at my trajectory and it is really following up on what Herb Needleman did and what Clare Patterson did, and that was finding the effects at lower and lower levels. Because what we do with lead and most other toxic chemicals, the ones that don't cause cancer, is we assume that there's a safe level or threshold until we prove otherwise. And yet when you look at the evidence, whether it's about asbestos and mesothelioma, air pollution and cardiovascular mortality, lead and cardiovascular mortality, benzene and leukemia, none of those exhibit a threshold. In some cases, the risks are steepest proportionately at the lowest measurable levels, and that really raises some tremendous challenges, right? Because how are we going to bring air pollution or lead down to zero? But at the same time, it also provides these tremendous opportunities because we know that they're causing disease. We know what the sources are. If we could only bring about the political will to address them, we could prevent a lot of death, disease, and disability. I mean, about 20% of deaths around the world every year are from air pollution, lead, and other toxic chemicals, and yet the amount of money we invest in them is just paltry compared to what we invest in other things. Which is not to pit one against the other, but it's to say we haven't invested enough in these.Eric Topol (19:14):No, absolutely. I think your point, just to make sure that it's clear, is that even at low levels, this is of course where most of the population exposure would be, and that's why that's so incriminating. Now, one of the things I just want to end up with is that we know that these are tiny, tiny particles of lead, and then the question is how they can synergize and find particulate matter of air pollution in the nanoplastic, microplastic story and binding to forever chemicals, PFAS. How do you process all that? Because it's not just a single hit here, it's also the fact that there's ability to have binding to the other environmental toxins that are not going away.Bruce Lanphear (20:10):That's right. And in a way, when we talk about lead playing this tremendous role in the rise and decline of coronary heart disease, we can't entirely separate it out, for example, from air pollution or cigarette smoke for that matter, nor plastic. So for example, with air pollution, if we look at air pollution over the past century, up until the 1980s, even into the 1990s, it was leaded, right? So you couldn't separate them. If you look at cigarette smoke, cigarette tobacco in the 1940s and 1950s was grown in fields where they used lead arsenic as an insecticide. So smokers even today have blood lead levels that are 20% higher than non-smokers, and people who are not smokers but exposed to secondhand smoke have blood lead levels 20% higher than non-smokers who aren't exposed to secondhand smoke. So in a way, we should try to tease apart these differences, but it's going to be really challenging. In a way we can almost think about them as a spectrum of exposures. Now with plastics, you can really think of plastics as a form of pollution because it's not just one thing. There's all these additives, whether it's the PFAS chemicals or lead, which is used as a stabilizer. And so, all of them really are kind of integrated into each other, which again, maybe there's some opportunity there if we really were ready to tackle.Eric Topol (21:40):And interestingly, just yesterday, it was announced by the current administration that they're stopping all the prior efforts on the forever chemicals that were initiated in the water supply. And I mean, if there's one takeaway from our discussion, it's that we have to get all over this and we're not paying enough attention to our environmental exposures. You've really highlighted spotlighted the lead story. And obviously there are others that are, instead of getting somewhat better, they're actually going in the opposite direction. And they're all tied together that's what is so striking here, and they all do many bad things to our bodies. So I don't know how, I'm obviously really interested in promoting healthy aging, and unless we get on this, we're chasing our tails, right?Bruce Lanphear (22:31):Well, I think that's right, Eric. And I was reading the tips that you'd written about in preparation for your book release, and you focused understandably on what each of us can do, how we can modify our own lifestyles. We almost need six tips about what our government should do in order to make it harder for us to become sick, or to encourage those healthy behaviors that you talked about. That's a big part of it as well. One of the things we're celebrating the hundredth anniversary. This is not really something to celebrate, but we are. The hundredth anniversary of the addition of tetraethyl lead to gasoline. And one of the key things about that addition, there was this debate because when it was being manufactured, 80% of the workers at a plant in New Jersey suffered from severe lead poisoning, and five died, and it was enough that New York City, Philadelphia and New Jersey banned tetraethyl lead.Bruce Lanphear (23:31):Then there was this convening by the US Surgeon General to determine whether it was safe to add tetraethyl lead to gasoline. One scientist, Yandell Henderson said, absolutely not. You're going to create a scourge worse than tuberculosis with slow lead poisoning and hardening of your arteries. Robert Kehoe, who represented the industry said, we know lead is toxic, but until you've shown that it's toxic when added to gasoline, you have no right to prohibit us from using it. So that is now known as the Kehoe rule, and it's relevant not only for lead, but for PFAS, for air pollution, for all these other things, because what it set as a precedent, until you've shown that these chemicals or pollution is toxic when used in commerce, you have no right to prohibit industry from using it. And that's the fix we're in.Eric Topol (24:27):Well, it sounds too much like the tobacco story and so many other things that were missed opportunities to promote public health. Now, is Canada doing any better than us on this stuff?Bruce Lanphear (24:40):In some ways, but not in others. And one of the interesting thing is we don't have standards, we have guidelines. And amazingly, the cities generally try to conform to those guidance levels. With water lead, we're down to five parts per billion. The US is sticking around with ten parts per billion, but it's not even really very, it's not enforced very well. So we are doing better in some ways, not so good in other ways. The European Union, generally speaking, is doing much better than North America.Eric Topol (25:15):Yeah, well, it doesn't look very encouraging at the moment, but hopefully someday we'll get there. Bruce, this has been a really fascinating discussion. I think we all should be thankful to you for dedicating your career to a topic that a lot of us are not up on, and you hopefully are getting us all into a state of awareness. And congratulations on that review, which was masterful and keep up the great work. Thank you.Bruce Lanphear (25:42):Thank you, Eric. I appreciate it.________________________________________________My Recommendations for Preventing Heart Disease (Markedly Truncated from Text and Graphics Provided in SUPER AGERS)Recently the Washington Post asked me for a listicle of 10 ways to prevent heart disease. I generally avoid making such lists but many people have de-subscribed to this newspaper, never subscribed, or missed the post, so here it is with links to citations:Guest column by Eric Topol, MDThe buildup of cholesterol and other substances in the wall of our arteries, known as atherosclerosis, is common. It can lead to severe plaques that narrow the artery and limit blood flow, or to a crack in the artery wall that can trigger blood clot formation, resulting in a heart attack.While we've seen some major advances in treating heart disease, it remains the leading killer in the United States, even though about 80 percent of cases are considered preventable. There are evidence-based steps you can take to stave it off. As a cardiologist, here's what I recommend to my patients.1. Do both aerobic and resistance exerciseThis is considered the single most effective medical intervention to protect against atherosclerosis and promote healthy aging. Physical activity lowers inflammation in the body. Evidence has shown that both aerobic and strength training forms of exercise are important. But only 1 in 4 Americans meet the two activity guidelines from the American Heart Association: aerobic exercise of 150 minutes per week of at least moderate physical activity, such as walking, bicycling on level ground, dancing or gardening, and strength training for at least two sessions per week, which typically translates to 60 minutes weekly.The protective benefit of exercise is seen with even relatively low levels of activity, such as around 2,500 steps per day (via sustained physical activity, not starting and stopping), and generally increases proportionately with more activity. It used to be thought that people who exercise only on the weekend — known as “weekend warriors” — put themselves in danger, but recent data shows the benefits of exercise can be derived from weekend-only workouts, too.2. Follow an anti-inflammatory dietA predominantly plant-based diet — high in fiber and rich in vegetables, fruits and whole grains, as seen with the Mediterranean diet — has considerable evidence from large-scale observational and randomized trials for reducing body-wide inflammation and improving cardiovascular outcomes.Foods rich in omega-3 fatty acids, such as salmon, also form part of a diet that suppresses inflammation. On the other hand, red meat and ultra-processed foods are pro-inflammatory, and you should limit your consumption. High protein intake of more than 1.4 grams per kilogram of body weight per day — around 95 grams for someone who is 150 pounds — has also been linked to promoting inflammation and to atherosclerosis in experimental models. That is particularly related to animal-based proteins and the role of leucine, an essential amino acid that is obtained only by diet.3. Maintain a healthy weightBeing overweight or obese indicates an excess of white adipose tissue. This kind of tissue can increase the risk of heart disease because it stores fat cells, known as adipocytes, which release substances that contribute to inflammation.In studies, we've seen that glucagon-like peptide (GLP-1) drugs can reduce inflammation with weight loss, and a significant reduction of heart attacks and strokes among high-risk patients treated for obesity. Lean body weight also helps protect against atrial fibrillation, the most common heart rhythm abnormality.4. Know and avoid metabolic syndrome and prediabetesTied into obesity, in part, is the problem of insulin resistance and metabolic syndrome. Two out of three people with obesity have this syndrome, which is defined as having three out of five features: high fasting blood glucose, high fasting triglycerides, high blood pressure, low high-density lipoprotein (HDL) and central adiposity (waist circumference of more than 40 inches in men, 35 inches in women).Metabolic syndrome is also present in a high proportion of people without obesity, about 50 million Americans. Prediabetes often overlaps with it. Prediabetes is defined as a hemoglobin A1c (a measure of how much glucose is stuck to your red blood cells) between 5.7 and 6.4 percent, or a fasting glucose between 100 and 125 milligrams per deciliter.Both metabolic syndrome and prediabetes carry an increased risk of heart disease and can be prevented — and countered — by weight loss, exercise and an optimal diet.As the glucagon-like peptide drug family moves to pills and less expense in the future, these medications may prove helpful for reducing risk in people with metabolic syndrome and prediabetes. For those with Type 2 diabetes, the goal is optimizing glucose management and maximal attention to lifestyle factors.5. Keep your blood pressure in a healthy rangeHypertension is an important risk factor for heart disease and is exceptionally common as we age. The optimal blood pressure is 120/80 mm Hg or lower. But with aging, there is often an elevation of systolic blood pressure to about 130 mm Hg, related to stiffening of arteries. While common, it is still considered elevated.Ideally, everyone should monitor their blood pressure with a home device to make sure they haven't developed hypertension. A mild abnormality of blood pressure will typically improve with lifestyle changes, but more substantial elevations will probably require medications.6. Find out your genetic riskWe now have the means of determining your genetic risk of coronary artery disease with what is known as a polygenic risk score, derived from a gene chip. The term polygenic refers to hundreds of DNA variants in the genome that are linked to risk of heart disease. This is very different from a family history, because we're a product of both our mother's and father's genomes, and the way the DNA variants come together in each of us can vary considerably for combinations of variants.That means you could have high or low risk for heart disease that is different from your familial pattern. People with a high polygenic risk score benefit the most from medications to lower cholesterol, such as statins. A polygenic risk score can be obtained from a number of commercial companies, though it isn't typically covered by insurance.I don't recommend getting a calcium score of your coronary arteries via a computed tomography (CT) scan. This test is overused and often induces overwhelming anxiety in patients with a high calcium score but without symptoms or bona fide risk. If you have symptoms suggestive of coronary artery disease, such as chest discomfort with exercise, then a CT angiogram may be helpful to map the coronary arteries. It is much more informative than a calcium score.7. Check your blood lipidsThe main lipid abnormality that requires attention is low-density cholesterol (LDL), which is often high and for people with increased risk of heart disease should certainly be addressed. While lifestyle improvements can help, significant elevation typically requires medications such as a statin; ezetimibe; bempedoic acid; or injectables such as evolocumab (Repatha), alirocumab (Praluent) or inclisiran (Leqvio). The higher the risk, the more aggressive LDL lowering may be considered.It should be noted that the use of potent statins, such as rosuvastatin or atorvastatin, especially at high doses, is linked to inducing glucose intolerance and risk of Type 2 diabetes. While this is not a common side effect, it requires attention since it is often missed from lack of awareness.A low high-density lipoprotein (HDL) cholesterol often responds to weight loss and exercise. We used to think that high HDL was indicative of “good cholesterol,” but more recent evidence suggests that is not the case and it may reflect increased risk when very high.To get a comprehensive assessment of risk via your blood lipids, it's important to get the apolipoprotein B (apoB) test at least once because about 20 percent of people have normal LDL and a high apoB.Like low HDL, high fasting triglycerides may indicate insulin resistance as part of the metabolic syndrome and will often respond to lifestyle factors.The lipoprotein known as Lp(a) should also be assessed at least once because it indicates risk when elevated. The good news is scientists are on the cusp of finally having medications to lower it, with five different drugs in late-stage clinical trials.8. Reduce exposure to environmental pollutantsIn recent years, we've learned a lot about the substantial pro-inflammatory effects of air pollution, microplastics and forever chemicals, all of which have been linked to a higher risk of heart disease. In one study, microplastics or nanoplastics in the artery wall were found in about 60 percent of more than 300 people. Researchers found a vicious inflammatory response around the plastics, and a four- to fivefold risk of heart attacks or strokes during three years of follow-up.While we need policy changes to address these toxic substances in the environment, risk can be reduced by paying attention to air and water quality using filtration or purification devices, less use of plastic water bottles and plastic storage, and, in general, being much more aware and wary of our pervasive use of plastics.9. Don't smoke This point, it should be well known that cigarette smoking is a potent risk factor for coronary artery disease and should be completely avoided.10. Get Good SleepAlthough we tend to connect sleep health with brain and cognitive function, there's evidence that sleep regularity and quality are associated with less risk of heart disease. Regularity means adhering to a routine schedule as much as possible, and its benefit may be due to our body's preference for maintaining its circadian rhythm. Sleep quality — meaning with fewer interruptions — and maximal deep sleep can be tracked with smartwatches, fitness bands, rings or mattress sensors.Sleep apnea, when breathing stops and starts during sleep, is fairly common and often unsuspected. So if you're having trouble sleeping or you snore loudly, talk to your doctor about ruling out the condition. Testing for sleep apnea can involve checking for good oxygen saturation throughout one's sleep. That can be done through a sleep study or at home using rings or smartwatches that include oxygen saturation in their sensors and body movement algorithms that pick up disturbed breathing.Eric Topol, MD, is a cardiologist, professor and executive vice president of Scripps Research in San Diego. He is the author of “Super Agers: An Evidence-Based Approach to Longevity” and the author of Ground Truths on Substack.*********************°°°°°°°°°°°°°°°°°°°°Thanks to many of you Ground Truths subscribers who helped put SUPER AGERS on the NYT bestseller list for 4 weeks.Here are 2 recent, informative, and fun conversations I had on the topicMichael Shermer, The SkepticRuss Roberts, EconTalk I'm also very appreciative for your reading and subscribing to Ground Truths.If you found this interesting PLEASE share it!That makes the work involved in putting these together especially worthwhile.All content on Ground Truths—its newsletters, analyses, and podcasts, are free, open-access.Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don't hesitate to post comments and give me feedback. Let me know topics that you would like to see covered.Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past three years. Just a week ago we just had nearly 50 interns (high school, college and medical students) present posters of the work they did over the summer and it was exhilarating! Some photos below Get full access to Ground Truths at erictopol.substack.com/subscribe

VOV1 - Trích Ghi nhanh không khí mừng chiến thắng tại Hồ Gươm chiều ngày 30-4-1975, do nhóm phóng viên Thời sự thực hiện.

This week on Bludging on the Blindside, Roy and HG discuss a disproportionate responses to a slight, Snoop Dog at the AFL granny, Trainers love the lime light, willynillyism, Names for the PNG team, a great grub is a slippery grub, betting on school raised racing dogs and down-in-the-dumpism.

Tối 13/8, tại Nhà hát Hồ Gươm (Hà Nội), Bộ Công an phối hợp với Hội Nhà báo Việt Nam tổ chức Lễ trao giải Báo chí toàn quốc “Vì An ninh Tổ quốc và bình yên cuộc sống” giai đoạn 2023-2025.

We know he is one of the all time great goal umpires - but Darkie Collins could send down a cricket ball as well, Mason 8 days sober and on fire, the boys look into the radio broadcast stoush from Wangaratta, a tribute from Roy and HG to our groundsman and the Indian cricket coach gets a double whammy ! 

Send us a text—This is an encore presentation of an episode previously published June 30—On this episode of the CMAJ Podcast, hosts Dr. Mojola Omole and Dr. Blair Bigham speak with two authors of the latest “Hypertension Canada guideline for the diagnosis and treatment of hypertension in adults in primary care”The discussion reflects a shared urgency: despite past successes, Canada's hypertension control rates are declining. The new guidelines aim to reverse this trend by simplifying diagnosis and treatment for frontline clinicians.Dr. Rémi Goupil, a nephrologist and clinician researcher at Sacré-Cœur Hospital in Montreal, and Dr. Greg Hundemer, a nephrologist and clinician scientist at The Ottawa Hospital, explain that the updated guideline is deliberately designed for primary care providers. They highlight key shifts: lowering the diagnostic threshold for hypertension to  ≥ 130/80 mm Hg, simplifying blood pressure targets, and emphasizing accurate, standardized measurement techniques both in clinic and at home. The guidelines were created with input from a majority-primary care committee—including family physicians, nurses, pharmacists, and patient partners—to ensure clinical applicability.Together, the panel outlines a streamlined nine-step treatment algorithm, emphasizing combination therapy as first-line pharmacologic management. They explain the evidence supporting ARB–thiazide combinations, discuss cost considerations for drug selection, and address adherence challenges. They also explore red flags for secondary hypertension and how the algorithm supports—but does not replace—clinical judgment.For physicians, this guideline offers a clear and practical roadmap: measure blood pressure correctly, aim for systolic pressure below 130 mm Hg, and use the simplified treatment sequence to improve adherence and outcomes. Designed to be easy to implement, the new approach aims to empower primary care providers to act with confidence.Join us as we explore medical solutions that address the urgent need to change healthcare. Reach out to us about this or any episode you hear. Or tell us about something you'd like to hear on the leading Canadian medical podcast.You can find Blair and Mojola on X @BlairBigham and @DrmojolaomoleX (in English): @CMAJ X (en français): @JAMC FacebookInstagram: @CMAJ.ca The CMAJ Podcast is produced by PodCraft Productions

This week on Bludging on the Blindside, Roy and HG discuss the rugby league runners - are they legit? Plan your life around rugby league, Alice Springs centre of excellence, the try celebration approval process, Runner agents - Is this something to consider? Billy Coleman the strongman of Lithgow, Horse racing base camp and where are the boxing TAFE courses?

A mix of rumours circling and the recently reviewed FiftyOne Sika road bike have Ronan and Dave pondering whether the UCI frame sticker is relevant to many of us. Spoiler, it's not.The episode was recorded a few days before we know for sure, but the social media profiles of athletes strongly point toward some interesting drop-bar-converted mountain bikes for the Leadville 100 race ahead.Ronan and Dave discuss a PSA for themselves, and of course, members of Escape Collective get access to the Ask a Wrench segment with Brad Copeland, where this week a handful of drivetrain-related questions are answered, including one about measuring for lateral chain wear.Enjoy!Time stamps:2:20 - The UCI approval sticker overrated16:50 - Wild bikes expected at Leadville31:30 - PSA for those with an air compressor40:00 - Standert's new Keiswerk44:00 - Ask a Wrench with Brad Copeland (Members Only)45:30 - Chasing noises that only occur under high load54:00 - Upgrading an old MTB drivetrain that's locked to an HG freehub1:03:00 - All about lateral chain wear

Welcome back to the Alt Goes Mainstream podcast.Today's episode is about mining for investment success in enterprise software by going “an inch wide and a mile deep” with someone who is one of the industry's most prolific private equity technology investors.We sat down with Nic Humphries in Hg's London office. Nic is the Senior Partner and Executive Chairman of Hg and Head of the firm's Saturn fund.Hg, one of the top 10 largest PE firms globally based on the PEI300 ranking, has built an impressive investment engine focused on mission-critical enterprise software. The firm has built a portfolio that is a “transatlantic ecosystem of software and services businesses” — representing over $180B in collective enterprise value across its 55 portfolio companies.Nic is responsible for Hg's strategy, management, and governance. On the investing side, Nic focuses on larger software investments that provide daily-use mission critical applications for accountants, tax / compliance professionals, and designers / engineers / scientists. He has brought his electrical engineering background to bear to go a “mile deep” into a category where Hg has become an unquestioned market leader.Nic balances being both a detail-oriented specialist with a vision for both the enterprise software industry and Hg as a firm. We had a fascinating discussion about enterprise software investing, how to create European software giants, applying AI to make companies more efficient, and much more.We covered:The origin story of Hg.How Hg grew into one of the industry's leading software focused private equity firms.How an engineering mindset has helped Nic become a leading investor.Why Hg focuses on mission-critical enterprise software and why it's a compelling investment thesis.Why enterprise software investing can be considered a low volatility investment strategy and how Hg has delivered consistent returns to investors.How to effectively manage exits and DPI.Why Europe, why now?How AI could impact technology and services businesses.Thanks Nic for coming on the show to share your wisdom and expertise about enterprise software and private markets.A word from AGM podcast sponsor, Juniper SquareWhen was the last time things were easy for GPs?Fundraising remains challenging, providing liquidity to investors is even harder—and broadly speaking, most GPs are underwater operationally.It's not about to get easier, either. Especially for managers vying for capital from the wealth channel. Sure, there's increased demand from HNW and UNHW investors to gain private markets exposure…but managing their expectations for the investing experience is a whole different ballgame.Reams of paper and a new KYC process every single time they subscribe to a fund? Brutal.But what if committing capital to private equity, venture, and real estate funds was digital and seamless for investors — and scalable to manage for GPs?Meet Juniper Square, the fund operations partner to over 2,000 private markets GPs worldwide.Juniper Square gives GPs the connected software, data, and fund administration services needed for modern private markets. No matter how ambitious your next raise is, how many investors you manage, and how complex your investment vehicles are, Juniper Square empowers GPs to raise capital faster, reduce operational risk, and deliver a world-class investor experience.And with JunieAI, Juniper Square's enterprise-grade AI built for private markets, GPs can truly and finally unlock the power of AI to work smarter, move faster, and focus on relationships and returns.Scale your business, not your operational burdens and costs. Visit junipersquare.com/agm today to learn more.Show Notes00:00 Introduction to our Sponsor, Juniper Square01:40 Introducing Nic Humphries01:56 Hg's Investment Strategy04:03 Nic's Background and Career Journey04:46 Engineering Mindset in Investing05:14 Long-Term Business Thinking05:58 Hg's Focus on Accounting Software06:45 Growth Drivers in SMB Market09:05 Impact of AI on Enterprise Software09:34 Platform Shifts in Technology11:10 Adapting to AI in Business12:15 Mission Critical Software14:02 Challenges of AI Integration14:58 Embedding Products and Services17:13 Organic Growth vs. Acquisitions20:51 Geographical Expansion Strategies21:59 European vs. North American Markets23:30 Management Teams and Expansion24:32 Jurisdictional Challenges in Europe25:05 Hg's Investment Philosophy25:50 Mission Critical Software in Europe36:22 Hg's Consistent Investment Returns38:00 Conclusion and Final Thoughts40:13 Understanding Recurring Revenues40:59 The Importance of Discipline in Investing41:48 Learning from Past Experiences43:30 Maintaining Excitement and Focus45:26 The Role of Realization Committees46:44 Continuous Improvement Culture47:42 The Importance of Cash Returns48:51 Exit Strategies and Realization Committees50:32 Re-underwriting Investments52:40 AI's Impact on Software Development54:17 The Rule of 40 and AI54:38 Investing in AI: Startups vs. Established Businesses55:59 Hg's Growth Strategy58:56 Specialization in B2B Back Office Software01:01:35 Fund Structure and Management01:03:27 Expanding into the Wealth Channel01:03:48 Hg Capital Trust and Fusion Fund01:05:27 Communicating with a Broader Audience01:06:39 The Importance of Brand in Wealth Management01:07:32 Connecting Private Markets to Everyday Life01:09:36 The Prevalence of Private Companies01:11:09 Aligning Interests with Investors01:12:19 Investment Decisions and Long-term Growth01:14:21 Future Growth Opportunities for Hg01:16:38 The Role of AI in Future Investments Editing and post-production work for this episode was provided by The Podcast Consultant.DisclaimerThe views and opinions expressed in this episode are those of the speaker and do not necessarily reflect the official policy or position of any affiliated organization.Any references to past performance, including IRR or MOIC figures, are presented on a gross basis and do not reflect the deduction of fees, expenses, or carried interest. These figures are illustrative and not necessarily indicative of future results. Statements regarding industry rankings, success rates, or performance consistency are based on internal analysis and may not be indepe...

Caterpillar (CAT) reported a revenue beat in its 2Q earnings figures, but fell shy of EPS top line expectations. Ben Watson examines the chart patterns formulating after the report. He uses the MACD study on a 5-day, 5-minute timeframe that shows near-term support around $421 and a slight reversal from initial weakness. On a 1-year timeframe, he points to the correlation to Copper futures (/HG) as something to watch.======== Schwab Network ========Empowering every investor and trader, every market day.Subscribe to the Market Minute newsletter - https://schwabnetwork.com/subscribeDownload the iOS app - https://apps.apple.com/us/app/schwab-network/id1460719185Download the Amazon Fire Tv App - https://www.amazon.com/TD-Ameritrade-Network/dp/B07KRD76C7Watch on Sling - https://watch.sling.com/1/asset/191928615bd8d47686f94682aefaa007/watchWatch on Vizio - https://www.vizio.com/en/watchfreeplus-exploreWatch on DistroTV - https://www.distro.tv/live/schwab-network/Follow us on X – / schwabnetwork Follow us on Facebook – / schwabnetwork Follow us on LinkedIn - / schwab-network About Schwab Network - https://schwabnetwork.com/about

Trong 6 tháng đầu năm 2025, Việt Nam đón hơn 10,6 triệu lượt du khách quốc tế, tăng 20,7% so với cùng kỳ năm 2024, tổng thu từ du lịch ước tính đạt 518 nghìn tỉ đồng (1). Việt Nam tích cực xây dựng hình ảnh với thế giới vì du lịch quốc tế là nguồn đóng góp trực tiếp quan trọng cho GDP, được kỳ vọng 6-8% năm 2025 với 980-1.050 tỉ đồng doanh thu. Bộ Văn Hóa Thể Thao và Du Lịch tổ chức nhiều hoạt động quảng bá du lịch Việt Nam tại nhiều hội chợ du lịch quốc tế và các nước châu Âu như Ý, Thụy Sĩ, Ba Lan, Séc, Đức, đặc biệt là tại Pháp thông qua các sự kiện điện ảnh lớn như Liên hoan phim Cannes 2025 và các hoạt động bên lề, quảng bá, xúc tiến du lịch tại Hội nghị thượng đỉnh Diễn đàn Đối tác vì tăng trưởng xanh và mục tiêu toàn cầu 2030 (P4G) lần thứ 4, giới thiệu Nhã nhạc cung đình Huế tại Quảng trường Trocadéro (Esplanade de Trocadéro), Paris tối 11/05… Tuy nhiên, chính những chuyến công du Việt Nam của các nhà lãnh đạo các nước lớn trên thế giới chính là một cách quảng cáo hữu hiệu cho du lịch Việt Nam. Ví dụ hình ảnh chuyến công du Hà Nội ngày 25-27/05/2025 của tổng thống Emmanuel Macron được truyền thông Pháp liên tục đưa tin. Đất nước thanh bình, an toàn Hình ảnh ông Macron cũng phu nhân thong dong đi dạo Hồ Gươm ngay trong đêm khi vừa mới đến Hà Nội được bình luận nhiều. Và đây cũng là cách “quảng bá hình ảnh của Việt Nam ra thế giới”, theo cảm nhận của bà Nguyễn Thị Lan chia sẻ với RFI Tiếng Việt khi đang cùng bạn chụp ảnh ở Hồ Gươm : “Tôi thấy những cuộc đi dạo phố Hà Nội của tổng thống Pháp rất ý nghĩa. Người ta là tổng thống nhưng hòa đồng với người dân Việt Nam, điều đó chứng tỏ người dân rất thân thiện. Cho nên, qua đó cũng quảng bá được hình ảnh người Việt Nam thân thiện, các di tích, danh lam thắng cảnh của Việt Nam sẽ được thế giới biết đến”. Anh Tiến, ngồi cùng nhóm bạn trong một quán cà phê đối diện Nhà Thờ Lớn, nơi tổng thống Pháp và phu nhân đến thăm hôm trước, chia sẻ : “Nhìn chung, mọi người đều có tâm trạng phấn khởi. Đối với một người dân Việt Nam như tôi, tôi cũng cảm thấy là có một chút gì đấy rất là hãnh diện, rất tự hào. Mình tự hào vì đất nước mình là một đất nước nhỏ, mình phát triển sau người ta cả một quãng rất là dài, còn người ta ở một nước phát triển hơn mà người ta sang và cảm nhận được cuộc sống của người Việt Nam, thì chắc người ta cũng rất ngưỡng mộ đấy. Chứ nếu mình mà là nước lớn thì chuyện lại khác. Đúng không?” “Việt Nam” cũng trở thành từ khóa được tìm kiếm nhiều sau khi xảy ra “sự cố” lúc mở cửa máy bay và bị đồn thổi là “tổng thống bị vợ tát”. Một yếu tố khác là tổng thống Macron phát biểu với báo chí, truyền thông chiều 26/05 ngay ngoài đường, đằng sau là một dãy xe máy. Tiếp theo là hình ảnh tổng thống và phu nhân được người dân Hà Nội đến chào và tặng quà khi rời khỏi nhà hàng Madame Hiền ở phố Hàng Bè. Anh Tiến cho rằng “phải cảm thấy thoái mái, cảm thấy đất nước thanh bình mà họ yên tâm” hòa vào đám đông. “Những hình ảnh đó mà được quảng bá lên thì khách du lịch nhìn vào đấy, người ta sẽ sang Việt Nam nhiều hơn. Mức độ tin tưởng hoặc là những phong cảnh của Việt Nam đẹp, cuộc sống rất là thanh bình, cho nên sẽ thu hút. Bởi vì bản thân tổng thống các nước đi sang Việt Nam, có cần phải có vệ sĩ đi đâu, không cần mà, người ta đi lại bình thường cũng như những người dân bình thường thôi mà. Người dân Việt Nam cũng rất là mến khách, điều đó ai cũng biết. Còn phong cảnh thì được ưu ái rất nhiều”. Nhiều công trình văn hóa, di tích lịch sử tại Hà Nội được đưa vào lịch trình tham quan và làm việc của tổng thống Pháp, như Phủ chủ tịch, lăng chủ tịch Hồ Chí Minh, Văn Miếu Quốc Tử Giám, Bảo tàng Mỹ thuật, Nhà thờ lớn, khu phố cổ, Hồ Gươm… Những công trình này mang phong cách kiến trúc đa dạng, từ truyền thống đến Đông Dương và hiện đại. Định vị thương hiệu du lịch qua ẩm thực Song song với việc đề cao di sản kiến trúc, danh lam thắng cảnh, Việt Nam cũng muốn “định vị thương hiệu du lịch qua ẩm thực”, theo báo Nhân Dân và “lan tỏa tinh hoa ẩm thực Việt Nam ra thế giới thông qua ngoại giao”. Tạp chí Thông tin & Truyền Thông viết : “Hình ảnh các nguyên thủ, lãnh đạo cấp cao các nước hay doanh nhân nước ngoài đi dạo, thưởng thức các món ăn đường phố tại Việt Nam dường như đã không còn quá xa lạ và dần trở thành một “đặc sản” để Việt Nam thông qua đó quảng bá ẩm thực, văn hóa, con người nước Nam với bạn bè quốc tế”. Tổng thống Barack Obama đi ăn bún chả, nhà sáng lập kiêm chủ tịch và giám đốc điều hành (CEO) Nvidia Hoàng Nhân Huân (Jensen Huang) đi uống bia ở phố Tạ Hiện, thủ tướng Úc Anthony Albanese uống bia, ăn bánh mì, CEO Apple Tim Cook uống cà phê trứng… Tổng thống Pháp Emmanuel Macron ăn nem rán, bún riêu tại nhà hàng Madame Hiền, nổi tiếng món dân dã Việt Nam nhưng do bếp trưởng người Pháp Didier Corlou điều hành. Chị Nguyễn Hoàng Yến, quản lý Nhà hàng Madame Hiền, giải thích với RFI Tiếng Việt là khi được biết là tổng thống Pháp sẽ đến ăn trưa làm việc với giới hoạt động văn hóa, nghệ thuật, bếp trưởng Didier Corlou “đã đưa ra một số thực đơn để họ thử và chọn, sau đó để điều chỉnh theo đúng gu”. “Nhà hàng Madame Hiền nổi tiếng về ẩm thực Việt Nam nhưng lại do bếp trưởng là người Pháp cho nên dùng toàn bộ sản phẩm thuần Việt và dùng các gia vị, rau thơm của Việt Nam. Thực đơn gửi đến đoàn của tổng thống Pháp gồm có nem rán, nem cuốn, có món bún riêu. Dù là những món ăn truyền thống nhưng hơi có phong cách của bếp trưởng. Điểm mạnh của ẩm thực Việt Nam nói chung và của Hà Nội nói riêng, theo tôi, đó là nhờ gia vị và “mùa nào thức đấy”, đặc biệt là rau thơm, rau củ quả đều tươi. Đấy cũng là điểm khiến bếp trưởng của nhà hàng Madame Hiền gắn bó với Việt Nam và quyết định mở nhà hàng về món ăn Việt Nam”. Kết hợp di sản kiến trúc với ẩm thực Ngoài ra, địa điểm cũng là thế mạnh của nhà hàng. Được xây từ năm 1928 theo thiết kế của kiến trúc người Pháp Lagisquet, căn biệt thự cổ vẫn giữ nguyên vẹn vẻ đẹp cổ kính theo kiến trúc Đông Dương. Theo chia sẻ của chị Hoàng Yến, đây là một trong năm biệt thự Pháp cổ được một thương gia người Pháp cải tạo, khai thác kinh doanh nhà hàng từ lâu. Những nét kiến trúc đặc trưng được bảo tồn cẩn thận để quảng bá tới du khách quốc tế khi đến Việt Nam. “Nhà hàng chọn khu biệt thự Pháp cổ, thường có quang cảnh và không gian mở để cho thực khách thưởng thức và có bầu không khí ấm cúng. Về không gian, nội thất, nhà hàng thử sử dụng như trong một gia đình Việt Nam, ấm cúng, không phải vào một nhà hàng sang trọng mà là vào một nhà hàng của gia đình Việt Nam. Món ăn bình dân nhưng vì bếp trưởng của nhà hàng từng làm trong khách sạn Métropole gần 20 năm, nên anh ấy sử dụng gia vị và rau thơm Việt Nam, nhưng thêm chút hương vị Pháp vào đó”. Thành phố Hà Nội đã lập danh sách những tòa biệt thự Pháp cổ còn lại ở Hà Nội, trong đó có rất nhiều công trình quan trọng sẽ được trùng tu để tạo thêm giá trị về kiến trúc, di sản, văn hóa. Theo Cơ quan hỗ trợ hợp tác quốc tế vùng Paris tại Việt Nam - PRX-Vietnam, hiện nhà tư vấn về bảo tồn di sản cho thành phố Hà Nội, nhiều biệt thự cổ sẽ được trùng tu để tạo thêm công năng mới như khách sạn, nhà hàng, quán cà phê, không gian triển lãm… Thực tế cần đúng với hình ảnh được quảng bá Tuy nhiên, đôi khi hình ảnh một Việt Nam thơ mộng bị phá vỡ bởi những thực tế kém hào nhoáng hơn. Trong bài “Điểm đến Việt Nam : những bất ngờ trong chuyến du lịch lớn đầu tiên đến châu Á” được đăng trên nhật báo Pháp Le Figaro ngày 14/07/2025, hai du khách trẻ người Pháp chia sẻ trải nghiệm, ngỡ ngàng cũng có và thất vọng cũng có : nắng nóng khắc nghiệt, ô nhiễm đô thị, và thậm chí là tình trạng quá tải ở một số địa điểm mang tính biểu tượng như Vịnh Hạ Long. Giao thông ở Hà Nội, đặc biệt là phố đường tàu, được coi là điểm đặc biệt nhưng nhanh chóng trở nên ngột ngạt, ồn ào, vì còi xe liên tục cùng với ô nhiễm không khí, khiến Agathe thấy hài lòng vì được đến với thiên nhiên Ninh Bình sau ba ngày ở Hà Nội. Tháng 07/2025, Việt Nam được tạp chí Time Out chọn là điểm du lịch kinh tế nhất và phong phú nhất ở Đông Nam Á. Ngoài giá vé máy bay thiếu cạnh tranh so với một số nước trong khu vực như Thái Lan, Singapore, chi phí ở Việt Nam không quá đắt, khuyến khích giới trẻ “xách ba lô lên và đi”. Ngoài ra, còn phải kể đến chính sách miễn thị thực. Việt Nam ký các hiệp định miễn thị thực song phương với nhiều quốc gia và đơn phương miễn thị thực cho công dân 13 nước (2), chủ yếu là các nước châu Âu, thời hạn tạm trú được nâng lên thành 45 ngày. Biện pháp có hiệu lực đến hết ngày 14/03/2028 và sẽ được xem xét gia hạn theo quy định của pháp luật Việt Nam. Trong 6 tháng đầu năm 2025, Bộ Văn Hóa, Thể Thao và Du Lịch đã xây dựng và triển khai Chương trình kích cầu phát triển du lịch năm 2025. Tuy nhiên, theo Báo Tuyên Quang ngày 28/07 (3), các nhà quản lý du lịch đều ý thức được rằng “để duy trì đà tăng trưởng và nâng cao chất lượng du lịch, Việt Nam cần tiếp tục đầu tư vào cơ sở hạ tầng, phát triển sản phẩm du lịch độc đáo, bền vững và đặc biệt là nâng cao chất lượng nguồn nhân lực”. (1) Theo báo cáo ngày 24/07/2025 của bộ Văn hóa, Thể Thao và Du lịch. (2) Đức, Pháp, Ý, Tây Ban Nha, Đan Mạch, Thụy Điển, Na Uy, Phần Lan, Anh và Bắc Ireland, Nga, Belarus, Nhật Bản, Hàn Quốc.  (3) Báo Tuyên Quang, "Hơn 10 triệu lượt khách du lịch quốc tế đến Việt Nam trong 6 tháng đầu năm 2025".

This week on Bludging on the Blindside, Roy and HG discuss Adam Reynolds' a front rower in a halfback's body, Reed Mahoney - Niggler or grub? Can the NRL handle Trump's 1700% tariff? Todd Payten can fire the grub button, is Andrew Leigh MP the rugby league candidate? Nothing like a family pig baiting, Baiting - a practical entry point and the fight hole at LIV golf.

This week on Bludging on the Blindside, Roy and HG discuss, are the Phins the new entertainers? English imports to rugby league, try celebration approvals, Tinkler comeback, dirty worded team songs, SBW vs Gallen wrap up - Haymakers in our undies and Kevvie's in the car park.

The JournalFeed podcast for the week of July 14-18, 2025.These are summaries from just 2 of the 5 articles we cover every week! For access to more, please visit JournalFeed.org for details about becoming a member.Monday Spoon Feed:A single high-quality CT scan is highly accurate at detecting serious cervical spine injuries in children after trauma and may be enough to clear the spine without further imaging safely in majority of patients.Thursday Spoon Feed:For patients with ROSC after OHCA who required vasopressors transported by Finnish helicopter EMS (HEMS), normotension (100-140 mm Hg) was associated with improved 30-day mortality compared to hypo and hypertension.Friday Spoon Feed:This study of a trauma database found patients intubated in the emergency department (ED) who required hemorrhage control surgery had worse outcomes than those who were intubated in the operating room (OR). However, a study published just two months ago, from the same database of patients, found no difference in patients based on intubation location. What gives?

This week on Bludging on the Blindside, Roy and HG discuss Queensland's origin win, Roy doesn't mind a backyard incinerator, comfortable jockey vests, sailor's language on the origin coverage, the blues don't need champs - they need a champion team, some Sea eagle fans hate Manly too, take the kids holiday pigg'in and they also have a finger on the line.

David Aspell says the market will care more about tariff threats if they're made against bigger trading partners. He thinks copper tariffs of 50% are “much higher” than the market expected, and its price surge has already had rippling consequences. He is bullish on copper (/HG) overall. “The [countries] we import copper from are generally friendly” to us, he adds, “The speed in which it's being implemented is quite surprising.”======== Schwab Network ========Empowering every investor and trader, every market day. Subscribe to the Market Minute newsletter - https://schwabnetwork.com/subscribeDownload the iOS app - https://apps.apple.com/us/app/schwab-...Download the Amazon Fire Tv App - https://www.amazon.com/TD-Ameritrade-...Watch on Sling - https://watch.sling.com/1/asset/19192...Watch on Vizio - https://www.vizio.com/en/watchfreeplu...Watch on DistroTV - https://www.distro.tv/live/schwab-net...Follow us on X – / schwabnetwork Follow us on Facebook – / schwabnetwork Follow us on LinkedIn - / schwab-network About Schwab Network - https://schwabnetwork.com/about

This week on Bludging on the Blindside, Roy and HG discuss the British Lions bash everyone, LIV Golf - watch it, vomit, party and go home, when's Cam going to get his own gameshow? Manly fans hate you too, BYD Tasmanian stadium, buying panther semen online, ground staff appreciation day.

Welcome back to the Alt Goes Mainstream podcast.Today's episode is with someone who has successfully built a wealth solutions business tailored to her firm's unique strengths, expertise, and investment track record.Martina Sanow is a Partner and Head of Hg Wealth, where she is focused on building the firm's wealth solutions offering built out of the $85B AUM firm, Hg, that invests in enterprise software.Hg, one of the top 10 largest PE firms globally based on the PEI 300 ranking, has built an impressive investment engine focused mission-critical enterprise software companies. The firm has built a portfolio that is a “transatlantic ecosystem of software and services businesses” — representing over $180B in collective enterprise value across its 55 portfolio companies.Martina has been at the firm for almost 16 years. She has been an integral part of building the firm into what it is today, helping Hg grow from $2B in AUM to $85B in AUM, previously as Deputy COO and now building the Hg Wealth business. Hg's first wealth offering, Fusion, its flagship evergreen fund that provides access to non-US investors to Hg's private equity funds and co-investment opportunities, has exceeded $1B in NAV just 12 months after its launch.Martina is thoughtful, strategic, and long-term oriented when it comes to building a solution that amplifies Hg's strengths and resonates with the wealth channel. We had a fascinating discussion about how a scaled specialist like Hg can stand out in the wealth channel, unpacking the essence of who Hg is as a firm and how they've expressed who they are as they've built their wealth business.We covered:Hg's evolution as a firm.Why Hg focuses on mission-critical enterprise software companies and why it's a compelling investment thesis.Building a wealth business that fits the mission, ethos, and strategy of the firm.Understanding the complexity of evergreen funds.How Martina and team think about managing dealflow and investor demand in their Fusion fund.Learnings applied from HgTrust, the publicly listed UK investment trust, to figuring out how to educate and build brand in the wealth channel.Why does ownership structure matter when it comes to building a wealth business? How being privately owned informs how Hg builds their wealth business.Why Europe, why now?Thanks Martina for coming on the show to share your wisdom and expertise at the intersection of enterprise software, private equity, and private wealth.A word from AGM podcast sponsor, Ultimus Fund SolutionsThis episode of Alt Goes Mainstream is brought to you by Ultimus Fund Solutions, a leading full-service fund administrator for asset managers in private and public markets. As private markets continue to move into the mainstream, the industry requires infrastructure solutions that help funds and investors keep pace. In an increasingly sophisticated financial marketplace, investment managers must navigate a growing array of challenges: elaborate fund structures, specialized strategies, evolving compliance requirements, a growing need for sophisticated reporting, and intensifying demands for transparency.To assist with these challenging opportunities, more and more fund sponsors and asset managers are turning to Ultimus, a leading service provider that blends high tech and high touch in unique and customized fund administration and middle office solutions for a diverse and growing universe of over 450 clients and 1,800 funds, representing $500 billion assets under administration, all handled by a team of over 1,000 professionals. Ultimus offers a wide range of capabilities across registered funds, private funds and public plans, as well as outsourced middle office services. Delivering operational excellence, Ultimus helps firms manage the ever-changing regulatory environment while meeting the needs of their institutional and retail investors. Ultimus provides comprehensive operational support and fund governance services to help managers successfully launch retail alternative products.Visit www.ultimusfundsolutions.com to learn more about Ultimus' technology enhanced services and solutions or contact Ultimus Executive Vice President of Business Development Gary Harris on email at gharris@ultimusfundsolutions.com.We thank Ultimus for their support of alts going mainstream.Show Notes00:00 Introduction and Message from Ultimus, our Sponsor01:55 Welcome to the Podcast01:58 Introducing Martina Sanow04:36 Martina's Background and Experience05:10 Hg's Specialization in Software05:57 Building a Team and Culture06:54 Importance of Cognitive Diversity07:26 Building a Diverse Team09:28 Innovating in Wealth Business10:14 Hg's Strategic Mindset11:51 Hg's Entrepreneurial Journey12:00 Maintaining Entrepreneurial Culture13:10 Specialization in B2B Software14:47 Focus on DPI and Cash Back16:17 Criteria for A-Quality Businesses16:58 Investing in Mission Critical Software18:11 Visma Case Study19:23 Challenges and Opportunities in Europe33:13 Evergreen Structures: Impact on Investment Teams33:44 Balancing Capital Raising and Deal Flow34:13 Investment Strategies and Allocation34:54 Managing Subscriptions and Demand35:53 Balancing Wealth and Institutional Demand36:06 Privately Owned Firm Benefits36:37 Realization Committee and Evergreen Structures37:52 Long-Term Company Partnerships39:11 Liquidity Management Challenges39:55 Investor Strategies for Evergreen Funds41:40 Institutional Adoption of Evergreen Funds42:48 Evolution of Institutional Mindset43:26 Retail vs. Wealth Investors44:01 Listed Trust and Wealth Business Insights45:54 Building the Wealth Business47:29 Strategic Importance of Wealth Capital48:54 Innovation in Wealth Management49:28 Partnerships and Holistic Solutions50:58 Future of Wealth Management Products52:44 Brand Building and Education55:00 Software as a Core Investment56:19 Community and Founder Investments59:28 Value Creation and Network Benefits01:00:15 Portfolio Synergies and Acquisitions01:01:36 Concluding Thoughts and Favorite InvestmentsEditing and post-production work for this episode was provided by The Podcast Consultant.

N Engl J Med 2004;351:2049-2057Background: Endothelial dysfunction, reduced nitric oxide availability, and increased oxidative stress occur in patients with heart failure and contribute to cardiac remodeling. In the V-HeFT I trial, combining isosorbide dinitrate (a nitric oxide donor) with hydralazine (an antioxidant) improved outcomes in patients with systolic heart failure. However, its long-term effectiveness in patients already receiving neurohormonal blockade was unclear.Cardiology Trial's Substack is a reader-supported publication. To receive new posts and support our work, consider becoming a free or paid subscriber.Racial differences exist in heart failure prevalence, mechanisms, and outcomes. Patients who identify as Black may have a less active renin–angiotensin system and lower nitric oxide availability. Prior analyses suggested that Black patients respond well to isosorbide dinitrate + hydralazine and respond less to Angiotensin Converting Enzyme Inhibitors (ACEi). For example, in a subgroup analysis of the V-HeFT I trial, isosorbide dinitrate + hydralazine reduced mortality in Black but not White patients.The African-American Heart Failure Trial (A-HeFT) sought to assess the efficacy of isosorbide dinitrate + hydralazine in Black patients with systolic heart failure.Patients: Patients were eligible if they self-identified as Black (defined as African decent), and had NYHA class III or IV heart failure for at least 3 months. The left ventricular ejection fraction had to be 35% or less or less than 45% if the ventricle was dilated. In addition, patients had to be on guideline medical therapy for at least 3 months.Patients were excluded if they had acute coronary syndrome or stroke within 3 months, cardiac surgery or percutaneous coronary intervention within 3 months, significant valvular disease, hypertrophic or restrictive cardiomyopathy plus many others.Baseline characteristics: Patients were recruited from 161 centers in the United States. The trial randomized 1,050 patients – 518 randomized to receive isosorbide dinitrate + hydralazine and 532 to receive placebo.The average age of patients was 57 years and 60% were men. The average left ventricular ejection fraction was 24% and the average left ventricular internal diastolic diameter was 6.5 cm. The cause of cardiomyopathy was ischemic in 23% of the patients, hypertensive in 39%, idiopathic in 26%, and other causes constituted the rest. The NYHA class was III in 96% of the patients. The average systolic blood pressure was 126 mm Hg.Approximately 40% had diabetes, 17% had chronic kidney disease and 17% had atrial fibrillation.At the time of enrollment, 90% were taking a diuretic, 69% were taking an ACEi, 17% were taking an angiotensin receptor blocker, 74% were taking a beta-blocker, 39% were taking spironolactone and 60% were taking digoxin.Procedures: The trial was double-blinded. Patients were randomized in a 1:1 ratio to receive fixed-dose combination of isosorbide dinitrate + hydralazine or to receive placebo. The initial dose was one tablet taken three times daily, containing either placebo or a combination of 37.5 mg of hydralazine and 20 mg of isosorbide dinitrate. If no side effects, the dose was increased to two tablets three times a day.Patients had follow up by phone every month and clinic visits every 3 months.Endpoints: The primary endpoint was a composite of weighted values of all-cause mortality, first hospitalization for heart failure within 18 months, and change in quality of life at 6 months. Quality of life was assessed using the Minnesota Living with Heart Failure Questionnaire, a 21-question self-administered questionnaire in which scores range from 0 to 5, with higher scores reflecting worse quality of life.The table below summarizes how the weighted score for the primary outcome was calculated.Analysis was performed based on the intention to treat principle. The main manuscript did not mention the estimated number of events for sample size calculation but did mention that 1,100 patients would provide sufficient power with a p

Send us a textOn this episode of the CMAJ Podcast, hosts Dr. Mojola Omole and Dr. Blair Bigham speak with two authors of the latest “Hypertension Canada guideline for the diagnosis and treatment of hypertension in adults in primary care”The discussion reflects a shared urgency: despite past successes, Canada's hypertension control rates are declining. The new guidelines aim to reverse this trend by simplifying diagnosis and treatment for frontline clinicians.Dr. Rémi Goupil, a nephrologist and clinician researcher at Sacré-Cœur Hospital in Montreal, and Dr. Greg Hundemer, a nephrologist and clinician scientist at The Ottawa Hospital, explain that the updated guideline is deliberately designed for primary care providers. They highlight key shifts: lowering the diagnostic threshold for hypertension to  ≥ 130/80 mm Hg, simplifying blood pressure targets, and emphasizing accurate, standardized measurement techniques both in clinic and at home. The guidelines were created with input from a majority-primary care committee—including family physicians, nurses, pharmacists, and patient partners—to ensure clinical applicability.Together, the panel outlines a streamlined nine-step treatment algorithm, emphasizing combination therapy as first-line pharmacologic management. They explain the evidence supporting ARB–thiazide combinations, discuss cost considerations for drug selection, and address adherence challenges. They also explore red flags for secondary hypertension and how the algorithm supports—but does not replace—clinical judgment.For physicians, this guideline offers a clear and practical roadmap: measure blood pressure correctly, aim for systolic pressure below 130 mm Hg, and use the simplified treatment sequence to improve adherence and outcomes. Designed to be easy to implement, the new approach aims to empower primary care providers to act with confidence.Join us as we explore medical solutions that address the urgent need to change healthcare. Reach out to us about this or any episode you hear. Or tell us about something you'd like to hear on the leading Canadian medical podcast.You can find Blair and Mojola on X @BlairBigham and @DrmojolaomoleX (in English): @CMAJ X (en français): @JAMC FacebookInstagram: @CMAJ.ca The CMAJ Podcast is produced by PodCraft Productions

Severe nausea and vomiting in pregnancy/hyperemesis gravidarum (HG) takes a toll on patient, and the healthcare system. According to a June 2024 ACOG Clinical Expert Series on the subject, GFD15 and IGFBP7 both play important roles in placentation, appetite, and cachexia that are linked to hyperemesis gravidarum. Specifically, LOW pre-pregnancy GFD15 is associated with increased frequency of HG as GFD15 levels spike post pregnancy in an otherwise "naive" system. Since metformin increases GFD15, can this be a pre-pregnancy, chemoprophylactic option in high risk women? New data just released (June 2025; AJOG) provides some eye-opening insights. Listen in for details.

Yaw, Tobs and Ohio are joined by Sim from WeAreTottenhamTV to talk all things Spurs including: Ange v Frank Kota Takai set to sign Which attacker suits Spurs best Which parts of the XI need strengthening HG quota issues Follow us across all socials - @newspursorder Learn more about your ad choices. Visit podcastchoices.com/adchoices

Was bedeutet es, ohne präsenten Vater aufzuwachsen – physisch, emotional oder transgenerational? In dieser Folge sprechen wir über die psychischen Folgen abwesender Väter: über Leere, Überanpassung, Schuldgefühle und die Suche nach Anerkennung. Anhand von Fallgeschichten zeigen wir, wie sich ein Vaterverlust auf Töchter, Söhne und Väter selbst auswirken kann. Wir fragen, warum manche Väter emotional nicht erreichbar sind und wie sich Kriegs- und Nachkriegserfahrungen bis heute fortsetzen. Eine Folge über Bindung, Verlust und die Chance, alte Muster zu durchbrechen. - Vertiefung: Wie abwesende Väter das Leben prägen und wie man sich daraus lösen kann: https://www.patreon.com/posts/132333688 - Jakobs Väterprojekt: https://www.springermedizin.de/postpartale-depression/postpartale-depression/einbezug-der-vaeter-in-die-stationaere-mutter-kind-therapie-mit-/19900536 - Vertiefungsfolge "Beendigung von Therapien" auf Patreon: https://www.patreon.com/posts/127931630 - Folge zu Glenn Gabbard und den "liebeskranken" Analytiker: https://www.patreon.com/posts/121877727?collection=148939 Skript zu dieser Folge: https://www.patreon.com/posts/132334002 Kontakt: lives@psy-cast.org Literaturempfehlungen: - Aigner, J. (2013): Der ferne Vater. Zur Psychoanalyse von Vatererfahrung, männlicher Entwicklung und negativem Ödipuskomplex. 3. Aufl., Gießen: Psychosozial-Verlag. - Steinhardt, K. / Datler, W. / Gstach, J. (Hrsg.) (2002): Die Bedeutung des Vaters in der frühen Kindheit. Gießen: Psychosozial-Verlag. - Radebold, H. (2020): Abwesende Väter und Kriegskindheit. Langzeitwirkungen auf die Nachkriegsgeneration. Stuttgart: Klett-Cotta. - Metzger, H-G. t u. a. (Hrsg.) (2008): Psychoanalyse des Vaters – Klinische Erfahrungen mit realen, symbolischen und phantasierten Vätern. Frankfurt a. M.: Brandes & Apsel. Erziehungskonzepte psychoanalytisch betrachtet (5 Teile): https://www.patreon.com/collection/148943 Digitaler Lesekreis zum Thema "Wie die Digitalisierung unsere psychische Struktur verändert" (1. Folge ist frei zugänglich): https://www.patreon.com/posts/lesekreis-werner-94838102 - Bestellung unseres Buches über genialokal: https://www.genialokal.de/Produkt/Cecile-Loetz-Jakob-Mueller/Mein-groesstes-Raetsel-bin-ich-selbst_lid_50275662.html und überall, wo es Bücher gibt. Auch als Hörbuch! - Link zu unserer Website: www.psy-cast.de - **Wir freuen uns auch über eine Förderung unseres Projekts via Paypal**: https://www.paypal.com/donate/?hosted_button_id=VLYYKR3UXK4VE&source=url - Anmeldung zum Newsletter: https://dashboard.mailerlite.com/forms/394929/87999492964484369/share Auf www.patreon.com/raetseldesubw finden sich noch viele weitere, spannende Themen (etwa eine Gesprächsreihe über berühmte Psychoanalytikerinnen und Psychoanalytiker, über die Tiefenpsychologie und Kulturgeschichte von Farben, Erziehung von damals bis heute...). Zudem gibt es hier die Skripte zu allen unseren Folgen. Unser Podcast ist ein Herzensprojekt, das wir in unserer abwesender Vater, Vaterkomplex, Vaterrolle, emotionale Vaterabwesenheit, transgenerationale Traumata, Vaterverlust Kindheit, psychische Folgen abwesender Väter, Vaterbindung, Männer und Vatersein, Väter in der Therapie, Vater-Kind-Beziehung, toxische Männlichkeit Ursprung, Bindungsstörungen Vater, postpartale Krise Vater

Join us this week as we unpack HG with Hailey who has firsthand experience.  She shares the story of her first pregnancy, the mental health battle it put her through, and what finally worked in the end.  Follow us on Instagram and TikTok @Moms_UncorkedPodcast 

This week on Bludging on the Blindside, Roy and HG discuss the strawberry moon effect on Cronulla, the Gould report is here, Spencer Leniu comes off the back fence, what happened to the magic sponge? To deal with pigs you need a rifle, AI refs, reputation crisis management, the Broncos bold new logo.

This week on Bludging on the Blindside, Roy and HG dive into the plans for the new stadium at Macquarie Point, placing a wager on Forest Jim to help pay off your mortgage, and clarifying that Touch Football in NOT Rugby League, Eric Abetz Tasmania's strongman, Kagiso Rabada's unexpected kitchen cameo, and some serious industrial baiting.

Tunes: Dan Nolan: Un Canadien Errant, the wandering Canadian, A La Claire Fontaine, by the clear Spring Jon Schurlock: Playing Highland Laddie from William Dixon Ryan G Kirk: Mary Scott (From Oswald) Jeremy Kingsbury: She Rose and Let Me In Dave Rowlands: 'La Bernardina' by Josquin des Pres Jeremy Kingsbury: The Carle He Came O'Er the Craft, Jim Harding's Waltz (from Dave Rowlands, and Waltzish from Nicholas Konradsen) Charlie Rutan: Tu Scendi Dalle Stelle Benjamin Elzerman: Jacks Gone-a-Shearing From William Vickers/Matt Seattle Jeremy Kingsbury: Taladh, Bundle and Go, You Silly Fool, Mr. Mackay's Jig, The Piper's Maggot, Woo'ed and Married an' a (From Donald Macdonald and Eliza Ross) James Moyar: Battle of Waterloo Jim Sanders: Napoleon Crossing the Rhine +X+X+X+ Thanks Everyone so much for your tune submissions and for listening to the show, If you want to pick up a Wetootwaag Shirt head over to https://www.bagpipeswag.com/ I've included the written texts I got from folks in the off chance I mispronounced things so badly you won't be able to connect the threads: +X+X+ From Dan Nolan: I'm playing “my first HG was made by luthier Gordiy Starukh of Lviv Ukraine which I bought in 2019. It's a 3 stringer in DG and in a style that dates to the 18th cent. The songs are Un Canadien Errant, the wandering Canadian, which was written in 1842 as a lament for rebels exiled from Canada after the failed Lower Canada Rebellion, 1837-8. The 2nd is A La Claire Fontaine, by the clear Spring, which dates back to 1604 and was originally a song of lost love but also become a resistance song after the British takeover following the F&I War. I wanted to learn some French Canadian song for French reenactors at vous and the Battle of PDC Wi. since a unit portraying the one that fought in that siege would come from Canada to participate in the event as it neared the 250th anniversary of the battle. From Ryan Kirk: Mary Scott Hey Jeremy here's a quick run at Oswald's variations on Mary Scott, a tune I learned from your podcast! I [am playing] an Aulos plastic [flute], copy of a 18th century Grenser. Very nice Instrument for the price. Thought about a wood one but humidity control in our old house is not great. From Dave Rowlands: This is 'La Bernardina' by Josquin des Pres (1450-1521). Not known as a composer for bagpipes, but the leading composer of his time. I have chosen this because a) it is a new find for me, b) because if pipers had access to this music and good instruments they would have played it, and c) because we should not be hidebound to 'tradition', just because it does not come from a bagpiping tradition, does not mean we cant play it, and i cite Amazing Grace as just one case. This is played by Three Swayne D pipes, and one Swayne G pipe. I hope you like it and include it. Best wishes, Dave R From Charlie Rutan: Tu Scendi Dalle Stelle is the traditional Italian Christmas carol played by zampognari. Originally called 'Quanno Nascente Ninno', it was written down in 1754 by St Alphonsus Ligouri, with text in the Neapolitan language: and became so popular that it was later translated into Italian and became 'TU SCENDI DALLE STELLE', undergoing several small changes in its melody during that process. The melody probably existed in various forms for several centuries prior to its 1754 transcription, and is still a basis for many improvised PASTORELLES by zampognari today. I'm playing both Ciaramella ( the Italian folk oboe) and Sei Palmi Zampogna on this track. 'Sei palmi' refers to the length of the instrument's longest chanter, measured by the outsretched palm of the pipe maker's hand, much like the 'cubit' of the ancient world. Zampongne have existed in this form since at least the early 1300's; where we have evidence of the instrument being played in frescoes dated to that time. The zampogna is endemic to southern Italy, exists in about 20 different iterations in several sizes, and is a thriving bagpipe tradition to this day. Hit https://www.bagpipesfao.com/ for more zampogna fun. FIN +X+X+ Here are some ways you can support the show: You can support the Podcast by joining the Patreon page at https://www.patreon.com/wetootwaag You can also take a minute to leave a review of the podcast if you listen on Itunes! Tell your piping and history friends about the podcast! Checkout my Merch Store on Bagpipeswag: https://www.bagpipeswag.com/wetootwaag You can also support me by Buying my Albums on Bandcamp: https://jeremykingsbury.bandcamp.com/ You can now buy physical CDs of my albums using this Kunaki link: https://kunaki.com/msales.asp?PublisherId=166528&pp=1 You can just send me an email at wetootwaag@gmail.com letting me know what you thought of the episode! Listener mail keeps me going! Finally I have some other support options here: https://www.wetootwaag.com/support Thanks! Listen on Itunes/Apple Podcasts: https://podcasts.apple.com/us/podcast/wetootwaags-bagpipe-and-history-podcast/id129776677 Listen on Spotify: https://open.spotify.com/show/5QxzqrSm0pu6v8y8pLsv5j?si=QLiG0L1pT1eu7B5_FDmgGA

N Engl J Med 2001;345:1667-1675Background: Angiotensin II is a peptide hormone that is part of the renin–angiotensin–aldosterone system (RAAS). Angiotensin II is a potent vasoconstrictor and growth-stimulating hormone. Data suggested that it plays a role in ventricular remodeling and progression of heart failure. Although treatment with angiotensin-converting enzyme inhibitors (ACEi) reduce angiotensin II levels, physiologically active levels of angiotensin II may persist despite long-term therapy.Cardiology Trial's Substack is a reader-supported publication. To receive new posts and support our work, consider becoming a free or paid subscriber.The Valsartan Heart Failure Trial (Val-HeFT) sough to assess whether the angiotensin-receptor blocker valsartan, could reduce mortality and morbidity when added to optimal medical therapy in patients with systolic heart failure.Patients: Eligible patients had left ventricular ejection fraction less than 40% and left ventricular dilation, in addition to having clinical heart failure for at least 3 months with NYHA class II, III or IV symptoms. Patient also had to have been receiving a fixed-dose drug regimen for at least two weeks, that could include ACEi, diuretics, digoxin, and beta-blockers.There were many exclusion criteria. We mention some here: Postpartum cardiomyopathy, acute myocardial infarction within 3 months, coronary artery disease likely to require intervention, serum creatinine >2.5 mg/dL and life expectancy less than 5 years.Baseline characteristics: Patients were recruited from 302 centers in 16 countries. The trial randomized 5,010 patients – 2,511 randomized to receive valsartan and 2,499 to receive placebo.The average age of patients was 63 years and 80% were men. The average left ventricular ejection fraction was 27%. Cardiomyopathy was ischemic in 57% of the patients. The NYHA class was II in 62% of the patients, III in 36% of the patients and IV in 2%.Approximately 26% had diabetes and 12% had atrial fibrillation.At the time of enrollment, 86% were taking a diuretic, 67% were taking digoxin, 35% were taking beta-blockers, and 93% were taking ACEi.Procedures: The trial was double-blinded. The trial had an initial run-in period for 2 - 4 weeks where patients received placebo twice daily. This was performed to confirm patients' eligibility, clinical stability and compliance.Patients were assigned in a 1:1 ratio to receive valsartan or placebo. Randomization was stratified according to whether or not they were receiving a beta-blocker.Valsartan was started at a dose of 40 mg twice a day, and the dose was doubled every two weeks to the target dose of 160 mg twice a day. Placebo doses were adjusted in a similar way.Follow up occurred at 2, 4, and 6 months and every 3 months thereafter.Endpoints: The trial had two primary end points. The first was all-cause mortality. The second was the combined end point of mortality and morbidity, which was defined as cardiac arrest with resuscitation, hospitalization for heart failure, or administration of intravenous inotropic or vasodilator drugs for four hours or more without hospitalization.The estimated sample size was 5,000 patients. The sample size calculation assumed 20% relative risk reduction in mortality with valsartan assuming 906 patients would die during the trial. This sample size would provide the trial 90% power at 0.02 alpha. Alpha was 0.02 instead of the traditional 0.05 since the trial had two primary endpoints and to adjust for the interim analyses.Results: The target valsartan dose of 160 mg twice a day was achieved in 84% of the patients. The reduction in systolic blood pressure was greater with valsartan vs placebo – mean of 5.2 ± 15.8 mm with valsartan compared to 1.2 ± 14.8 mm Hg with placebo, at 4 months.All-cause mortality was not different between both groups (19.7% with valsartan vs 19.4% with placebo, RR: 1.02, 95% CI: 0.88 – 1.18; p= 0.80). The second co-primary endpoint was reduced with valsartan (28.8% vs 32.1%, RR: 0.87, 95% CI: 0.77 – 0.97; p= 0.009). This was driven by reduction in hospitalizations for heart failure (13.8% vs 18.2%). Cardiac arrest with resuscitation was 0.6% with valsartan and 1.0% with placebo. All-cause hospitalization was numerically lower with valsartan, however, this was not statistically significance (2,856 vs 3,106; p= 0.14). The mean change in ejection fraction was higher with valsartan (4.0% vs 3.2%; p= 0.001). More patients had improvement in NYHA classification with valsartan (23.1% vs 20.7%; p

Most times we record at HG. This week we recorded at a DIFFERENT HG. HighGrain's Silverton taproom gave us a fresh perspective and a location for our Q2 video, so be sure to look for that on YouTube! This episode has us contemplating things such as Mike's hair switching places, shining examples of good businesses and people, beer pardons, how many ounces make a good beer sample, an actual schnapp (schnapps?) for the schnappening, Garage Beer owning goats when they should be in the UFL-sphere, and not knowing if something is a beer or an ice cream. Get the best potato chips in the entire world here: https://dickspotatochips.com/ ----- This episode covers the following shows : Barstool Perspective (YouTube) - 5/30/2025 The Weekly Pint - Ep 264 - A New Braxton Taproom, Garage Beer Owns A Team, and My Ice Cream Is Hard? ----- What we drank :  HighGrain Brewing - Lusen - Pilsner HighGrain Brewing - Guilia - Italian Pilsner ----- Episode recorded on 6/3/2025 at our amazing podcast host, High Grain's Silverton taproom! https://www.highgrainbrewing.com/ Disclaimer: The views and opinions expressed by Truth, Beer, and Podsequences are those of the participants alone and do not necessarily reflect the views or opinions of any entities they may represent. ------  Links to everything at http://truthbeerpod.com/ or https://truthbeerpod.podbean.com/ Find us on all the social medias @ TruthBeerPod Email us at TruthBeerPod@gmail.com Subscribe, like, review, and share! Find all of our episodes on your favorite Podcast platform or https://www.youtube.com/@TruthBeerPod ! Buy us a pint!  If you'd like to support the show, you can do by clicking the "One-Time Donation" link at http://truthbeerpod.com ! If you want exclusive content, check out our Patreon!  https://www.patreon.com/TruthBeerPod If you'd like to be a show sponsor or even just a segment sponsor, let us know via email or hit us up on social media! ----- We want you to continue to be around to listen to all of our episodes.  If you're struggling, please reach out to a friend, family member, co-worker, or mental health professional.  If you don't feel comfortable talking to someone you know, please use one of the below resources to talk to someone who wants you around just as much as we do.   Call or Text 988 to reach the Suicide and Crisis Lifeline Chat with someone at 988lifeline.org http://www.988lifeline.org ----- Our Intro, Outro, and most of the "within the episode" music was provided by Gnome Creative. Check out www.GnomeCreative.com for all your audio, video, and imagery needs! @gnome__creative on Instagram @TheGnarlyGnome on Twitter https://thegnarlygnome.com/support http://gnomecreative.com http://instagram.com/gnome__creative http://www.twitter.com/TheGnarlyGnome

This week on Bludging on the Blindside, Roy and HG discuss game 1 of State of Origin - Billy was a man without an answer, has Gus mislead us? How Stomper Staines dealt with a sex ban, practice your groundings and schools should be shoot'in and trapp'in.

The FiltrateJoel TopfAC GomezSophia AmbrusoNayan AroraSpecial Guest Charles Edelstein, MD, PhD Professor, Medicine-Renal Med Diseases/HypertensionExtra-Special GuestMichelle Rheault, MD Professor of Pediatrics, University of MinnesotaEditing bySimon and Joel TopfThe Kidney Connection written and performed by by Tim YauShow NotesKDIGO ADPKD Guidelines:WebsiteGuideline PDFExecutive Summary PDFNephJC coverageConsortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP)Hy's Law (Wikipedia) has three components:ALT or AST by 3-fold or greater above the upper limit of normalAnd total serum bilirubin of greater than 2× the upper limit of normal, without findings of cholestasis (defined as serum alkaline phosphatase activity less than 2× the upper limit of normal)And no other reason can be found to explain the combination of increased aminotransferase and serum total bilirubin, such as viral hepatitis, alcohol abuse, ischemia, preexisting liver disease, or another drug capable of causing the observed injuryMeeting this definition yields a very high risk of fulminant kidney failure (76% in one series)Clinical Pattern of Tolvaptan-Associated Liver Injury in Subjects with Autosomal Dominant Polycystic Kidney Disease: Analysis of Clinical Trials Database (PubMed) Two of 957 patients on tolvaptan met Hy's law criteria. None had fulminant kidney failure.Effects of Hydrochlorothiazide and Metformin on Aquaresis and Nephroprotection by a Vasopressin V2 Receptor Antagonist in ADPKD: A Randomized Crossover Trial (PubMed) Patients had a baseline urine volume on tolvaptan of 6.9 L/24 h. Urine volume decreased to 5.1 L/24 h with hydrochlorothiazide and to 5.4 L/24 h on metformin.TEMPO 3:4 Tolvaptan in Patients with Autosomal Dominant Polycystic Kidney Disease (NEJM)Reprise Trial Tolvaptan in Later-Stage Autosomal Dominant Polycystic Kidney Disease ( NEJM | NephJC )Unified ultrasonographic diagnostic criteria for polycystic kidney disease by Edelstein in JASN (PubMed)Tolvaptan and Kidney Function Decline in Older Individuals With Autosomal Dominant Polycystic Kidney Disease: A Pooled Analysis of Randomized Clinical Trials and Observational Studies (PubMed)Charles' draft choice Recommendation 4.1.1.1: We recommend initiating tolvaptan treatment in adults with ADPKD with an estimated glomerular filtration rate (eGFR) ‡25 ml/min per 1.73 m2 who are at risk for rapidly progressive disease (1B).Sophia's draft choice Recommendation 1.4.2.1: We recommend employing the Mayo Imaging Classi cation (MIC) to predict future decline in kidney function and the timing of kidney failure (1B).Progression to kidney failure in ADPKD: the PROPKD score underestimates the risk assessed by the Mayo imaging classification (Frontiers of Science)AC's draft choice Recommendation 9.2.1: We recommend targeting BP to ≤ 50th percentile for age, sex, and height or ≤ 110/70 mm Hg in adolescents in the setting of ADPKD and high BP (1D).HALT-PKD Blood Pressure in Early Autosomal Dominant Polycystic Kidney Disease (NEJM)Nayan's draft choice Recommendation 6.1.2: We recommend screening for ICA in people with ADPKD and a personal history of SAH or a positive family history of ICA, SAH, or unexplained sudden death in those eligible for treatment and who have a reasonable life expectancy (1D).Screening for Intracranial Aneurysms in Patients with Autosomal Dominant Polycystic Kidney Disease (CJASN)Surgical Clipping Versus Endovascular Coiling in the Management of Intracranial Aneurysms (PubMed) Clipping is associated with a higher rate of occlusion of the aneurysm and lower rates of residual and recurrent aneurysms, whereas coiling is associated with lower morbidity and mortality and a better postoperative course.Joel's editorial pick Recommendation 6.1.1: We recommend informing adults with ADPKD about the increased risk for intracranial aneurysms (ICAs) and subarachnoid hemorrhage (1C).Joel's first draft pick The bring out your dead pick:Recommendation 4.3.1: We recommend not using mammalian target of rapamycin (mTOR) inhibitors to slow kidney disease progression in people with ADPKD (1C).Recommendation 4.4.1: We suggest not using statins specfiically to slow kidney disease progression in people with ADPKD (2D).Recommendation 4.5.1: We recommend not using metformin specifically to slow the rate of disease progression in people with ADPKD who do not have diabetes (1B).Recommendation 4.6.1: We suggest that somatostatin analogues should not be prescribed for the sole purpose of decreasing eGFR decline in people with ADPKD (2B).Perfect match: mTOR inhibitors and tuberous sclerosis complex (Orphanet Journal of Rare Diseases)Navitor Pharmaceuticals Announces Janssen Has Acquired Anakuria Therapeutics, Inc. (BioSpace) This is press release about acquiring the mTor1 inhibitor.Joel's second draft pick Recommendation 4.2.1.1: We suggest adapting water intake, spread throughout the day, to achieve at least 2–3 liters of water intake per day in people with ADPKD and an eGFR ≥ 30 ml/min per 1.73 m2 without contraindications to excreting a solute load (2D).Nayan's bonus draft Practice Point 4.7.1: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) should not be used to slow eGFR decline in people with ADPKD.Open-Label, Randomized, Controlled, Crossover Trial on the Effect of Dapagliflozin in Patients With ADPKD Receiving Tolvaptan (KIReports)SMART Trial of GLP-1ra in non-diabetics: Semaglutide in patients with overweight or obesity and chronic kidney disease without diabetes: a randomized double-blind placebo-controlled clinical trial (PubMed)Tubular SecretionsNayan: Landman on Paramount Plus (IMDB)Sophia: PassNayan: steps in with The Pitt on HBO (Wikipedia)Charles: The White Lotus, Yellowstone 1923, Poirot (IMDB)AC: The PittMichael Crichton's Estate Sends The Pitt to the Courtroom (Vulture)Joel: I Must Betray you by Ruta Sepetys (Amazon)

Story at-a-glance Tai chi, yoga, and mindfulness techniques lowered blood pressure by 5 to 10 mm Hg in just eight to 12 weeks, delivering results similar to low-dose medications when practiced consistently Stress reduction methods like deep breathing and meditation worked in the short term but lost effectiveness when people stopped practicing them, showing the importance of daily commitment A large study found that tai chi was more effective than aerobic exercise at lowering systolic blood pressure, with more participants reaching normal levels compared to those doing aerobics Blood pressure medications often come with side effects like fainting, kidney injury, and cognitive decline, making natural alternatives like tai chi and lifestyle changes a safer first step Managing your nervous system with sun exposure, grounding, and daily relaxation practices gives you control over your blood pressure without relying on drugs or short-term fixes